Hydrogels can maintain a high local drug concentration during treatments and may be useful to local targeting diseased areas. We propose a pH sensitive hydrogel consisting of polyvinylpyrrolidone (PVP) and chitosan as a new treatment method for KRAS mutant lung cancer. Addition of dopamine improved the drug loading and release effects of this hydrogel. We demonstrate that Tasquinimod-loading of this dopamine-modified pH sensitive hydrogel is more effective than Tasquinimod alone for inhibiting the proliferation of KRAS mutant lung cancer cells. Combina-tion of conventional drugs with hydrogels may thus provide a new treatment modality for lung cancer.

The data was collected directly during the experiment and processed by GraphPad Prism and Origin Graph.

We uploaded all reusable files and original data, which can be processed in GraphPad Prism and Origin Graph to achieve the results we presented.