Education is associated with Aβ burden in preclinical familial and sporadic Alzheimer’s disease
Gonneaud, Julie et al. (2021), Education is associated with Aβ burden in preclinical familial and sporadic Alzheimer’s disease, Dryad, Dataset, https://doi.org/10.5061/dryad.ttdz08kth
Results. Asymptomatic individuals with a parental history of sporadic AD showed increased β-amyloid burden associated with APOE-ε4 carriage and lower level of education, but no interaction between these. Pre-symptomatic mutation carriers of autosomal dominant AD showed no relation between APOE-ε4 and β-amyloid burden, but increasing level of education was associated with reduced β-amyloid burden. The association between educational attainment and β-amyloid burden was similar in the two cohorts.
Conclusions. While the APOE-ε4 allele confers increased tendency toward β-amyloid accumulation in sporadic AD only, protective environmental factors, like increased education, may promote brain resistance against β-amyloid pathology in both sporadic and autosomal dominant AD.