Each of these file corresponds to a figure in the main paper or in the supplementary materials.

figure1.csv

• Thal is Thal phase which is measured by histopathology. This is an
  ordinal variable with no units.
• Braak is Braak neurofibrillary tangle stage. This is an ordinal
  variable with no units. Braak stages are sometimes styled using Roman
  numerals.
• Group is a composite variable representing how we combined Thal
  phase and Braak stage.

---

figure2.csv

• region is the location in the brain where the flortaucipir PET
  tracer was measured. The regions are as follows:
  1. ERC, entorhinal cortex
  2. Anterior HP or AHP, anterior hippocampus
  3. Fusiform or FFG, fusiform gyrus
  4. Inferior temporal or ITG, inferior temporal gyrus
  5. Superior frontal or SFG, superior frontal gyrus
  6. Precuneus or PRCU, precuneus
  7. Superior parietal or SPG, superior parietal gyrus
  8. Calcarine or CAL, calcarine
  9. Precentral or PrCG, precentral gyrus
• thal is the Thal phase as in figure1.csv.
• braak is the Braak stage as in figure1.csv.
• estimates corresponds to the model-based estimated geometric mean
  standardized uptake value ratio (SUVR) from the generalized additive
  model. This variable is a ratio and unitless although some
  researchers use the phrase “SUVR units.”

---

figure3.csv and figure3_labels.csv1

This figure can be thought of as a 6 Thal phases (rows) by 7 Braak
stages (columns) grid and within each “cell” is a 3x3 sub array
corresponding to the 9 regions. The estimates for the figure are in a
(6 * 3) x (7 * 3) = 18 x 21 matrix found in figure3.csv. They are scaled
to the unit interval.

The file figure3_labels.csv gives the coordinates for the region
labels.

• position_x_axis is the position on the x-axis in terms of the unit
  interval.
• position_y_axis is the position on the y-axis in terms of the unit
  interval.
• roi is the region of interest, or simply region, label. The
  regions here are abbreviated. See above for the mapping between
  abbreviation and region of interest.

---

figure4.csv

• erc_tau is the entorhinal cortex flortaucipir SUVR value for each
  individual in the study and is plotted in panel B.
• group is the four-level composite group used throughout the paper.
• braak is the Braak stage as in figure1.csv.
• thal is the Thal phase as in figure1.csv.
• cerad stands for “Consortium to Establish a Registry for
  Alzheimer’s Disease (CERAD)” and is an ordinal neuropathology
  variable.
• pib is the Pittsburgh Compound B (PiB) group. PiB is the amyloid
  PET ligand used in this study. The label “PiB +” corresponds to an
  elevated (abnormal) PiB SUVR, “PiB -“ corresponds to a normal PiB
  SUVR, and “No PiB” means the participant did not have a PiB scan.

---

figureS1.csv

• region is the 9-level region or region of interest (ROI) as in
  figure2.csv.
• position_x_axis is the position on the x-axis for plotting.
• contrast is an ordinal variable which indicates which Braak stages
  are being contrasted (or differenced).
• estimates is the estimate for the contrast, or the estimated
  percentage difference based on the generalized additive models
  summarized in Figure 2.
• lcl corresponds to the lower 95% confidence limit.
• ucl corresponds to the upper 95% confidence limit.

---

figureS2_S4.csv

The data for Figure S2 and S4 are the same and can be thought of as a
variation of Figure 2 but using partial volume correction (PVC) to
account for atrophy. Figure S2 has Braak stage on the x-axis and lines
for Thal phase while Figure S4 has Thal phase on the x-axis with lines
for Braak stage.

• region is the 9-level region or region of interest (ROI) as in
  figure2.csv.
• thal is the Thal phase as in figure1.csv.
• braak is the Braak stage as in figure1.csv.
• estimates corresponds to the model-based estimated geometric mean
  standardized uptake value ratio (SUVR) from the generalized additive
  model fit to PVC data.

---

figureS3.csv

This figure is similar to Figure S1 but here Thal phases are being
contrast.

• region is the 9-level region or region of interest (ROI) as in
  figure2.csv.
• position_x_axis is the position on the x-axis for plotting.
• contrast is an ordinal variable which indicates which Thal phases
  are being contrasted (or differenced).
• estimates is the estimate for the contrast, or the estimated
  percentage difference in means based on the
  generalized additive models summarized in Figure 2.
• lcl corresponds to the lower 95% confidence limit.
• ucl corresponds to the upper 95% confidence limit.

---

figureS5.csv

This figure gives the estimated mean SUVR for combinations
of Braak stage and Thal phase for six different model fits.

• model is the model being fit. This is a categorical variable with
  six levels.
• region is the 9-level region or region of interest (ROI) as in
  figure2.csv.
• position_y_axis is the y-axis position for plotting. It
  corresponds to the Thal phase with jittering.
• braak is the Braak stage as in figure1.csv.
• estimates is the estimated geometric mean flortaucipir SUVR for the
  Braak-Thal combination for a particular model.
• lcl corresponds to the lower 95% confidence limit.
• ucl corresponds to the upper 95% confidence limit.

---

figureS6.csv

• region is the 9-level region or region of interest (ROI) as in
  figure2.csv.
• group is an eight-level grouping variable indicating the person-level
  group.
• taupet is the within-region, person-level flortaucipir PET SUVR value.

---

figureS7.csv

• position_x_axis gives the position on the x-axis (the Braak axis)
  for the point plotted.
• position_y_axis gives the position on the y-axis (the Thal axis)
  for the point plotted.
• erc_group is the entorhinal cortex (ERC) SUVR group.
• number_subjects is the number of participants for the given
  combination of Thal, Braak, CERAD, and PiB. (For CERAD and PiB, see
  figure4.csv.)
• cerad as in figure4.csv.
• pib as in figure4.csv.

---

figureS8.csv

• thal is the Thal phase as in figure1.csv.
• centiloid is the amyloid PET centiloid value. This is a rescaling
  of PiB whereby 0 represents the mean SUVR value for a reference group
  of controls and 100 represents the mean SUVR value for a reference
  group of individuals with Alzheimer’s. Note that values below 0 and
  above 100 are possible.
• cerad as in figure4.csv.
• group is the four-level composite group used throughout the paper.