Hoffmann, Constanze1; Zimmermann, Fee1; Biek, Roman2; Kuehl, Hjalmar3; Nowak, Kathrin1; Mundry, Roger3; Agbor, Anthony3; Angedakin, Samuel3; Arandjelovic, Mimi3; Blankenburg, Anja1; Brazolla, Gregory3; Corogenes, Katherine3; Couacy-Hymann, Emmanuel4; Deschner, Tobias3; Dieguez, Paula3; Dierks, Karsten3; Düx, Ariane1; Dupke, Susann1; Eshuis, Henk3; Formenty, Pierre5; Ginath Yuh, Yisa3; Goedmakers, Annemarie6; Gogarten, Jan1; Granjon, Anne-Céline3; McGraw, Scott7; Grunow, Roland1; Hart, John8; Jones, Sorrel3; Junker, Jessica3; Kiang, John9; Langergraber, Kevin10; Lapuente, Juan3; Lee, Kevin3; Leendertz, Siv Aina; Léguillon, Floraine1; Leinert, Vera11; Löhrich, Therese1; Marrocoli, Sergio3; Mätz-Rensing, Kerstin12; Meier, Amelia3; Merkel, Kevin; Metzger, Sonja1; Murai, Mizuki3; De Nys, Hélène1; Sachse, Andreas1; Schenk, Svenja; van Schijndel, Joost3; Thiesen, Ulla1; Ton, Els6; Wu, Doris1; Wieler, Lothar1; Boesch, Christophe3; Klee, Silke1; Wittig, Roman3; Calvignac-Spencer, Sébastien1; Leendertz, Fabian1
Published Mar 01, 2018
on Dryad.
https://doi.org/10.5061/dryad.v8bn7
Anthrax is a globally significant animal disease and zoonosis. Despite this, current knowledge of anthrax ecology is largely limited to arid ecosystems, where outbreaks are most commonly reported. We reveal cryptic the dynamics of an anthrax causing agent, Bacillus cereus biovar anthracis, in a tropical rainforest with severe consequences for local wildlife communities. Using data and samples collected over three decades we found that rainforest anthrax is a persistent and widespread cause of death for a broad range of mammalian hosts. We predict that this pathogen will accelerate the decline and possibly result in the extirpation of local chimpanzee (Pan troglodytes verus) populations. Our findings illuminate the epidemiology of a cryptic pathogen and have important implications for conservation and public health.
SNP_Alignment_TNP_Bcbva_Chromosome
Alignment of variant sites of chromosomal Bcbva sequences from TNP (Côte d’Ivoire, n=124) and Grebo (Liberia, n=2). One sequence per host hosts (mammals/flies, two divergent isolates for fly 600) was included and the final alignment of variant sites is 298bp long.
SNP_Alignment_TNP_Bcbva_pXO1
Alignment of variant sites of Bcbva plasmid pXO1 sequences from TNP (Côte d’Ivoire, n=124) and Grebo (Liberia, n=2). One sequence per host hosts (mammals/flies, two divergent isolates for fly 600) was included and the final alignment of variant sites is 18bp long.
SNP_Alignment_TNP_Bcbva_pXO2
Alignment of variant sites of Bcbva plasmid pXO2 sequences from TNP (Côte d’Ivoire, n=124) and Grebo (Liberia, n=2). One sequence per host hosts (mammals/flies, two divergent isolates for fly 600) was included and the final alignment of variant sites is 11bp long.
SNP_Alignment_sub-Saharan_Africa_Bcbva_Chromosome
Alignment of variant sites of chromosomal Bcbva sequences from Côte d'Ivoire (CI), Cameroon (CAM), Liberia (505-4 and 506-4) and CAR (363-2 and 364-1). The final alignment of variant sites is 1016bp long.
