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Dryad

A normative database of free-breathing pediatric thoracic 4D dynamic MRI images

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May 09, 2024 version files 641.49 MB

Abstract

In pediatric patients with respiratory abnormalities, it is important to understand the alterations in regional dynamics of the lungs and other thoracoabdominal components, which in turn requires a quantitative understanding of what is considered as normal in healthy children. Currently, such a normative database of regional respiratory structure and function in healthy children does not exist. The shared open-source normative database is from our ongoing virtual growing child (VGC) project, which includes 4D dynamic magnetic resonance imaging (dMRI) images during one breathing cycle for each normal child and also 10 object segmentations at end expiration (EE) and end inspiration (EI) phases of the respiratory cycle in the 4D image. The lung volumes at EE and EI as well as the excursion volumes of chest wall and diaphragm from EE to EI, left and right separately, are also reported. The database has 2,820 3D segmentations from 141 healthy children, which to our knowledge is the largest dMRI dataset of healthy children to date. The database is unique and provides dMRI images, object segmentations, and quantitative regional respiratory measurement parameters of volumes for healthy children. The database can serve as a reference standard to quantify regional respiratory abnormalities in young patients with various respiratory conditions and facilitate treatment planning and response assessment. The database can be useful to advance future AI-based research on image-based object segmentation and analysis.