Encoding and control of airflow orientation by a set of Drosophila fan-shaped body neurons
Cite this dataset
Nagel, Katherine; Currier, Timothy; Matheson, Andrew (2020). Encoding and control of airflow orientation by a set of Drosophila fan-shaped body neurons [Dataset]. Dryad. https://doi.org/10.5061/dryad.vq83bk3rh
Abstract
The insect Central Complex (CX) is thought to underlie goal-oriented navigation but its organization is still not fully understood. We recorded from genetically-identified CX cell types in Drosophila and presented directional visual, olfactory, and airflow cues known to elicit orienting behavior. We found that a group of neurons targeting the ventral fan-shaped body (ventral P-FNs) are robustly tuned for airflow direction. Ventral P-FNs did not generate a “map” of airflow direction. Instead, cells in each hemisphere were tuned to 45° ipsilateral, forming a pair of orthogonal bases. Imaging experiments suggest that ventral P-FNs inherit their airflow tuning from neurons that provide input from the lateral accessory lobe (LAL) to the noduli (NO). Silencing ventral P-FNs prevented flies from selecting appropriate corrective turns following changes in airflow direction. Our results identify a group of central complex neurons that robustly encode airflow direction and are required for proper orientation to this stimulus.
Methods
Electrophysiology data from genetically labeled neurons in the central complex of Drosophila
Imaging data from genetically labeled neurons in Drosophila
Behavioral data from Drosophila collected in a closed-loop flight paradigm
Funding
National Institute on Deafness and Other Communication Disorders, Award: R01DC017979
National Science Foundation, Award: IOS-1555933
McKnight Foundation, Award: Scholar Award
New York University, Award: Dean's Dissertation Fellowship