Estimating the abundance or density of wildlife populations is a critical part of species conservation and management, but estimates can vary greatly in precision and accuracy according to the data collection and statistical methods, sampling and ecological variation, and sample size. N-mixture models are a common method which has been applied to a wide range of taxa for estimating population abundance from non-invasive data representing the distribution of the species. We used population estimates from an aerial survey of moose and videos from camera traps to assess the sensitivity of N-mixture models to ecological conditions, the spatial scale at which they were measured, the criteria used to define independent detections, and model choice based on the common statistical criterion of parsimony. The most parsimonious N-mixture models were considerably biased, producing implausibly large and considerably imprecise estimates of the abundance of moose. Most of the other models produced estimates of abundance that were ecologically realistic and relatively accurate. The accuracy of population estimates produced by N-mixture models were not overly sensitive to the formulation of models, the scale at which ecological conditions were measured, or the criteria used to define independent detection and by extension sample size. Our results suggest that parsimony was a poor measure of the predictive accuracy of the population estimates produced with the N-mixture model. Collecting and processing data from the aerial survey was less expensive and took less time, but data from camera traps can provide valuable information on behavior of the target species as well as insights into multiple species in the community.