Innate and adaptive immune genes associated with MERS-CoV infection in dromedaries
Data files
Jun 28, 2021 version files 21.01 MB
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CamDro3_exons.gff.gz
2.92 MB
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CamDro3_genes.gff.gz
1.64 MB
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CamDro3_introns.gff.gz
2.27 MB
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immune-gene-baits.fasta-against-CamDro3.fa.blast.2.bed.gz
6.36 KB
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immune-gene-baits.fasta.gz
564.37 KB
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Lado_et_al_BioinformaticScripts_27-01-2021.txt
60.15 KB
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new-list-of-candidates-merged.bed.gz
890 B
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new-list-of-candidates-sprot-annotation.gff3.gz
4.12 KB
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Read_me.txt
1.58 KB
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stitch.mers.k14.n100000.filtered-0.90.recode.polymorphic.vcf
13.55 MB
Sep 22, 2021 version files 21.01 MB
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CamDro3_exons.gff.gz
2.92 MB
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CamDro3_genes.gff.gz
1.64 MB
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CamDro3_introns.gff.gz
2.27 MB
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immune-gene-baits.fasta-against-CamDro3.fa.blast.2.bed.gz
6.36 KB
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immune-gene-baits.fasta.gz
564.37 KB
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Lado_et_al_BioinformaticScripts_27-01-2021.txt
60.15 KB
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new-list-of-candidates-merged.bed.gz
890 B
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new-list-of-candidates-sprot-annotation.gff3.gz
4.12 KB
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Read_me.txt
1.58 KB
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stitch.mers.k14.n100000.filtered-0.90.recode.polymorphic.vcf
13.55 MB
Abstract
The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune- response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7).