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Innate and adaptive immune genes associated with MERS-CoV infection in dromedaries

Citation

Lado, Sara et al. (2021), Innate and adaptive immune genes associated with MERS-CoV infection in dromedaries, Dryad, Dataset, https://doi.org/10.5061/dryad.x69p8czh6

Abstract

The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune- response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7).