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MGMT promoter methylation and IDH mutation detected in 301 patients with GBM

Citation

Ji, Nan (2020), MGMT promoter methylation and IDH mutation detected in 301 patients with GBM, Dryad, Dataset, https://doi.org/10.5061/dryad.xsj3tx9d4

Abstract

The datasets had listed the information of IDH mutation or wildtype at c.395G>A and MGMT promoter methylation status in 301 samples with GBM.

Methods

MGMT promoter methylation and IDH mutation were detected by sequencing.

Usage Notes

Variant_Classification of each sample was shown in the datasets of IDH1 status sheet. Variant_Classification was based on cDNA_Change(c.395G>A is for missense_variant,c.395G>G is for wild_type). MGMT promoter_CpG was detected by pyrosequencing and was displayed in the datasets of the MGMT promoter status sheet. The samples were considered MGMT promoter methylated with average methylation of >10% in MGMT promoter_CpG.