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Data from: An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes

Citation

Kratochwil, Claudius et al. (2021), Data from: An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes, Dryad, Dataset, https://doi.org/10.5061/dryad.zs7h44j9p

Abstract

Polymorphisms have fascinated biologists for a long time, but their genetic underpinnings often remained elusive. Here, we aimed to uncover the genetic basis of the gold/dark polymorphism that is eponymous of Midas cichlid fish (Amphilophus spp.) adaptive radiations in Nicaraguan crater lakes. While most Midas cichlids are of the melanic “dark morph”, about 10% of individuals lose their melanic pigmentation during their ontogeny and transition into a conspicuous “gold morph”. Using a new haplotype-resolved long-read assembly we discovered an 8.2kb, transposon-derived inverted repeat in an intron of an undescribed gene, which we term goldentouch in reference to the Greek myth of King Midas. The gene goldentouch is differentially expressed between morphs, likely due to structural implications of inverted repeats in both DNA and RNA (cruciform and hairpin formation). The near-perfect association with the phenotype across several independent populations suggests that this insertion likely underlies this trans-specific, stable polymorphism.

Funding

Deutsche Forschungsgemeinschaft, Award: 423396155

Deutsche Forschungsgemeinschaft, Award: 290977748

Deutsche Forschungsgemeinschaft, Award: 219669982

European Research Council, Award: 293700

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Award: P300PA_177852

European Molecular Biology Organization, Award: ALTF 47-2018

Instituto Serrapilheira, Award: Serra-529

CAPES, Award: PrInt-PGGen