This data contains imaging data from two cohorts of Parkinson's disease and control subjects, recruited from the Emory Movement Disorders Clinic and scanned on two different MRI scanners. In Cohort 1, imaging data from 19 controls and 22 Parkinson’s disease patients were acquired with a Siemens Trio 3 Tesla scanner using a 2D gradient echo sequence with magnetization transfer preparation pulse. Cohort 2 consisted of 33 controls and 39 Parkinson’s disease patients who were scanned on a Siemens Prisma 3 Tesla scanner with a similar imaging protocol.

Cohort 1 data was collected from 2012–2014 and included 19 controls and 22 PD patients. Cohort 2 consisted of 33 healthy controls (HC) and 39 PD patients with data collected from 2015–2016. Controls were recruited from the community and the Emory Alzheimer’s Disease Research Center control population.

MRI data for Cohort 1 were acquired with a Siemens Trio 3 Tesla scanner (Siemens Medical Solutions, Malvern, PA, USA) at Emory University with a 12-channel receive-only head coil. NM-MRI data was acquired using a 2D magnetization transfer (MT) prepared gradient echo (GRE) sequence [13, 14]: echo time (TE) / repetition time (TR) = 2.68 ms / 337 ms, slice thickness 3 mm, in plane resolution 0.39x0.39 mm², field of view (FOV) = 162–200 mm², flip angle (FA) = 40°, 470 Hz/pixel bandwidth, 15 contiguous slices, and magnetization transfer preparation pulse (300°, 1.2 kHz off resonance, 10 ms duration), 7 measurements, scan time 16 minutes 17 seconds. For registration from subject space to common space, a T1 magnetization-prepared rapid gradient echo (MP-RAGE) sequence was acquired with the following parameters: TE/TR= 3.02 ms/2600 ms, inversion time = 800 ms, FA=8°, voxel size = 1.0 x 1.0 x 1.0 mm³.

Cohort 2 was scanned with a Siemens Prisma 3 Tesla scanner using a 64-channel receive-only coil. NM-MRI data were acquired using a 2D GRE sequence with a MT preparation pulse: TE/TR = 3.10 ms /354 ms, 15 contiguous slices, FOV = 162–200 mm², in plane resolution = 0.39 x 0.39 mm²), slice thickness = 3mm, 7 measurements, FA = 40°, 470 Hz/pixel receiver bandwidth, and MT pulse (300°, 1.2 kHz off resonance, 10 ms duration), scan time 17 minutes 12 seconds. For registration, structural images were acquired with an MP-RAGE sequence: TE/TR = 2.46 ms/1900 ms, inversion time = 900 ms, FA = 9°, voxel size = 0.8 x 0.8 x 0.8 mm^3_.

Data are raw and have not been processed.

Any image processing software (i.e. SPM, FSL, AFNI, ImageJ).