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Dryad

Longitudinal analysis of the microbiome and metabolome in the 5xfAD mouse model of Alzheimer's disease

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Nov 29, 2022 version files 1.32 MB

Abstract

Here we evaluate longitudinal microbiomes and metabolomes from a popular transgenic mouse model for familial Alzheimer’s disease (5xfAD). This data is comprised of metagenomics of both cecal and fecal samples, metabolomics of fecal samples, and metabolomics of blood plasma. Samples were collected from 5xfAD mice and their WT B6J littermates from 4 – 18 months of age. Differences in microbiome and metabolite composition with relation to genotype, sex, age, and housing were explored. This study was conducted as part of the MODEL-AD consortium (model-ad.org).