GENERAL INFORMATION 1. Title of Dataset: Multichannel ECoG and LFP from Control and Cuprizone mice 2. Author Information A. Principal Investigator Contact Information Name: Maarten Kole Institution: NIN Email: m.kole@nin.knaw.nl B. Associate or Co-investigator Contact Information Name: Mohit Dubey Institution: NIN Email: m.dubey@nin.knaw.nl Recommended citation for this dataset: https://doi.org/10.7554/eLife.73827 METHODOLOGICAL INFORMATION Chronic ECoG and LFP recordings were performed using in-house made electrodes of platinum iridium wire (101R-5T, 90% Pt, 10% Ir, complete diameter of 200 µm with 127 µm metal  diameter, Science Products). The perfluoroalkoxy alkanes (PFA) coated wire platinum-iridium wire was only exposed at the tip to record the local field potential (LFP). For placement of the recording electrode, animals were anesthetized with isoflurane (3%, flow rate 0.8 L/min with maintenance 1.5–1.8%, flow rate 0.6 L/min). A 1 cm midline sagittal incision was made starting above the interaural line and extending along the neck to create a pocket for subcutaneous placement of the transmitter along the dorsal flank of the animal. The recording electrodes in each hemi-sphere (stereotaxic coordinates relative to bregma: S1; –0.15 mm anterior and ± 0.30 mm lateral; for LFP; ventral 0.75 mm, V1; 0.40 mm anterior and ± 0.30 mm lateral; for LFP; ventral 0.75 mm) and ground electrode (6 mm posterior and 1 mm lateral) were implanted sub durally through small holes drilled in the skull, held in place with stainless steel screws (A2-70, Jeveka) and subsequently sealed with dental cement. Mice were provided with Metachem analgesic (0.1 mg per kg) after surgery and allowed to recover for 4–7 days before recordings. To obtain multiple hours recordings of ECoG-LFP at multiple weeks, mice remained in their home cage during an overnight recording session. ECoG–LFP data were collected using a ME2100-system (Multi channel Systems); ECoG-LFP data were acquired at a sampling rate of 2 kHz using the multi-channel experimenter software (Multi channel systems). The data was exported and saved as EDF format using Multichannel Datamanager 1.102.18296 (Multi channel systems) DATA & FILE OVERVIEW File List: M5_8Weeks.edf M4_8Weeks.edf M9M10_8Weeks.edf M17M18_8Weeks.edf M6M7_8Weeks.edf M11M13_8Weeks.edf Mice identities: Control Mice; M5, M9, M10, M17, M18 8 weeks Cuprizone treated Mice: M4, M6, M7, M11, M13 Recorded channel identities: 7 Channels signals from each mice sampled at 2000 Hz: E1/E9 = ECoG_S1_right  E2/E10 = LFP_S1_right E3/E11 = ECoG_S1_left E4/E12 = ECoG_V1_right E5/E13 = ECoG_V1_left E6/E14 = LFP_V1_left E7/E15 = EMG DATA-SPECIFIC INFORMATION FOR: [M5_8Weeks.edf] E1 = ECoG_S1_right  E2 = LFP_S1_right E3 = ECoG_S1_left E4 = ECoG_V1_right E5 = ECoG_V1_left E6 = LFP_V1_left E7 = EMG DATA-SPECIFIC INFORMATION FOR: [M4_8Weeks.edf] E1 = ECoG_S1_right  E2 = LFP_S1_right E3 = ECoG_S1_left E4 = ECoG_V1_right E5 = ECoG_V1_left E6 = LFP_V1_left E7 = EMG DATA-SPECIFIC INFORMATION FOR: [M9M10_8Weeks.edf] M9 E1 = ECoG_S1_right  E2 = LFP_S1_right E3 = ECoG_S1_left E4 = ECoG_V1_right E5 = ECoG_V1_left E6 = LFP_V1_left E7 = EMG M10 E9 = ECoG_S1_right  E10 = LFP_S1_right E11 = ECoG_S1_left E12 = ECoG_V1_right E13 = ECoG_V1_left E14 = LFP_V1_left E15 = EMG DATA-SPECIFIC INFORMATION FOR: [M17M18_8Weeks.edf] M17 E1 = ECoG_S1_right  E2 = LFP_S1_right E3 = ECoG_S1_left E4 = ECoG_V1_right E5 = ECoG_V1_left E6 = LFP_V1_left E7 = EMG M18 E9 = ECoG_S1_right  E10 = LFP_S1_right E11 = ECoG_S1_left E12 = ECoG_V1_right E13 = ECoG_V1_left E14 = LFP_V1_left E15 = EMG DATA-SPECIFIC INFORMATION FOR: [M6M7_8Weeks.edf] M6 E1 = ECoG_S1_right  E2 = LFP_S1_right E3 = ECoG_S1_left E4 = ECoG_V1_right E5 = ECoG_V1_left E6 = LFP_V1_left E7 = EMG M7 E9 = ECoG_S1_right  E10 = LFP_S1_right E11 = ECoG_S1_left E12 = ECoG_V1_right E13 = ECoG_V1_left E14 = LFP_V1_left E15 = EMG DATA-SPECIFIC INFORMATION FOR: [M11M13_8Weeks.edf] M11 E1 = ECoG_S1_right  E2 = LFP_S1_right E3 = ECoG_S1_left E4 = ECoG_V1_right E5 = ECoG_V1_left E6 = LFP_V1_left E7 = EMG M13 E9 = ECoG_S1_right  E10 = LFP_S1_right E11 = ECoG_S1_left E12 = ECoG_V1_right E13 = ECoG_V1_left E14 = LFP_V1_left E15 = EMG