This README.txt file was generated on 2022-03-03 by Rob Gillis GENERAL INFORMATION 1. Title of Dataset: Data from: mRNA expression analysis of the hippocampus in a vervet monkey model of fetal alcohol spectrum disorder 2. Author Information Corresponding Investigator Name: Dr Roberta Palmour Institution: McGill University, Dept of Human Genetics Email: roberta.palmour@mcgill.ca Co-investigator 1 Name: Rob Gillis, PhD ABD Institution: McGill University, Dept of Human Genetics 3. Date of data collection: 2009-2015 4. Geographic location of data collection: Montreal Qc, Canada 5. Funding Sources for this dataset: CIHR 6. Recommended citation for this dataset: Gillis, Palmour (2022), Data From: mRNA expression analysis of a vervet monkey model of fetal alcohol spectrum disorder Data and File Overview 1. Description of dataset: These data were generated to understand the molecular pathology of prenatal ethanol exposure via differential mRNA expression 2. File List File 1: Name: Allcandidategeneralpoolagealcohol File 1: Description: This file contains all of the expression data, all annotations, all p-values, q-values, fold changes for every annotated probe set. File 2: Name: apriorirationale File 2: Description: This file contains the genes that were selected prior to the onset of the experiment for inclusion in the candidate gene pool using alcohol as a main effect. Not all of these genes were discovered, expressed or annotated when we obtained the array data File 3: Name: candidate pool File 3: Description: This file contains the expression data corresponding to the genes from the apriori candidate pool along with their p-values and q-values File 4: Name: functionalannotationage File 4 Description This CSV contains the full results of our pathway analysis for the 297 genes with the lowest p-values using age as a main effect File 5: Name: functionalannotationalcohol File 5: Description: This CSV contains the full results of our pathway analysis for the 297 genes with the lowest p-values using alcohol as a main effect. File 6: Name: generalpool File 6: Description: This CSV contains all of the data related to the remaining genes on the array after the apriori genes were analyzed separately. File 7: Name: qrtpcrddct File 7: Description: This CSV contains the analysis of the qPCR data File 8: Name: qrtpcrrawdata File 8: Description: This CSV contains all of the raw data related to the qRT-PCR File 9: Name: SampleInfo File 9: Description: This CSV contains monkey names, numbers, alcohol dosage, age at sacrifice and age at which alcohol was administered. Methodological Information Full methods are available in publication titled: mRNA expresssion analysis of the hippocampus in a vervet monkey model of fetal alcohol spectreum disorder Journal of Neurodevelopmental disorders. Data Specific information for File 1: a) Number of variables: 2 b) Number of Rows: 11,512 c) Variable List: Age, Alcohol d) Missing data codes: none Data Specific Information for File 2: a) Number of variables: N/A b) Number of Rows: 2243 c) Variable List: N/A d) Missing data codes: N/A Data Specific Information for File 3: a) Number of variables: 2 b) Number of Rows: 1524 c) Variable List: Age, Alcohol d) Missing data codes: N/A Data Specific Information for File 4: a) Number of variables: N/A b) Number of Rows: N/A c) Variable List: N/A d) Missing data codes: N/A Data Specific Information for File 5: a) Number of variables: N/A b) Number of Rows: 9990 c) Variable List: Age/Alcohol d) Missing data codes: N/A Data Specific Information for File 6: a) Number of variables: 2 b) Number of Rows: 9990 c) Variable List: Age/Alcohol d) Missing data codes: N/A Data Specific Information for File 7: a) Number of variables: 2 b) Number of Rows: N/A c) Variable List: Age/Alcohol d) Missing data codes: N/A Data Specific Inforamtion for File 8: a) Number of variables: 2 b) Number of Rows: N/A c) Variable List: Age/Alcohol d) Missing data codes: N/A Data Specific Inforamtion for File 9: a) Number of variables: N/A b) Number of Rows: N/A c) Variable List: N/A d) Missing data codes: N/A