PMID- 26679334 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20181202 IS - 1488-2159 (Electronic) IS - 0709-8936 (Linking) VI - 81 DP - 2015 TI - MANAGEMENT OF DENTAL EXTRACTIONS IN PATIENTS TAKING WARFARIN AS ANTICOAGULANT TREATMENT: A SYSTEMATIC REVIEW. PG - f20 AB - OBJECTIVES: The management of patients on anticoagulation therapy is challenging. The objective of this study was to conduct a systematic review to establish the effectiveness of hemostatic interventions to prevent postoperative bleeding following dental extractions among patients taking warfarin. METHODS: A systematic review of the literature was conducted using PubMed, EMBASE and the Cochrane Central Register of Controlled Trials databases and applying relevant MeSH terms. Identified studies were screened independently by 2 reviewers using the following selection criteria: tooth extraction, patients taking warfarin as the only anticoagulant, randomized controlled trials and a hemostatic intervention. RESULTS: Six articles were included in the final review, all evaluating different interventions. Oral or local hemostatic agents were compared in 4 studies where patients continued taking warfarin before and after the procedure; in 3 studies, there were no differences between the agents in preventing postoperative bleeding and, in 1, Histoacryl glue was superior to a gelatin sponge. Two studies compared warfarin continuation with temporary discontinuation and found that continuation did not increase the risk of bleeding in patients who had an international normalized ratio (INR) within the therapeutic range. CONCLUSIONS: Patients with an INR within the therapeutic range can safely continue taking the regular dose of warfarin before dental extractions. There is no evidence to support or reject the superiority of local hemostatic agents over warfarin discontinuation. FAU - Weltman, Naamah Jacobs AU - Weltman NJ FAU - Al-Attar, Yasmeen AU - Al-Attar Y FAU - Cheung, Johnson AU - Cheung J FAU - Duncan, David Philip Bruce AU - Duncan DP FAU - Katchky, Ashley AU - Katchky A FAU - Azarpazhooh, Amir AU - Azarpazhooh A FAU - Abrahamyan, Lusine AU - Abrahamyan L AD - University of Toronto, Toronto, ON. LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - Canada TA - J Can Dent Assoc JT - Journal (Canadian Dental Association) JID - 7907605 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM MH - Anticoagulants/*administration & dosage MH - Dental Care for Chronically Ill/*methods MH - Hemostasis, Surgical/*methods MH - Humans MH - International Normalized Ratio MH - Oral Hemorrhage/*prevention & control MH - Postoperative Hemorrhage/*prevention & control MH - *Tooth Extraction MH - Warfarin/*administration & dosage EDAT- 2015/12/19 06:00 MHDA- 2016/12/15 06:00 CRDT- 2015/12/19 06:00 PHST- 2015/12/19 06:00 [entrez] PHST- 2015/12/19 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] PST - ppublish SO - J Can Dent Assoc. 2015;81:f20. PMID- 29502332 OWN - NLM STAT- MEDLINE DCOM- 20180427 LR - 20200511 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 3 IP - 3 DP - 2018 Mar 4 TI - Interventions for treating post-extraction bleeding. PG - CD011930 LID - 10.1002/14651858.CD011930.pub3 [doi] LID - CD011930 AB - BACKGROUND: Post-extraction bleeding (PEB) is a recognised, frequently encountered complication in dental practice, which is defined as bleeding that continues beyond 8 to 12 hours after dental extraction. The incidence of post-extraction bleeding varies from 0% to 26%. If post-extraction bleeding is not managed, complications can range from soft tissue haematomas to severe blood loss. Local causes of bleeding include soft tissue and bone bleeding. Systemic causes include platelet problems, coagulation disorders or excessive fibrinolysis, and inherited or acquired problems (medication induced). There is a wide array of techniques suggested for the treatment of post-extraction bleeding, which include interventions aimed at both local and systemic causes. This is an update of a review published in June 2016. OBJECTIVES: To assess the effects of interventions for treating different types of post-extraction bleeding. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 24 January 2018), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2017, Issue 12), MEDLINE Ovid (1946 to 24 January 2018), Embase Ovid (1 May 2015 to 24 January 2018) and CINAHL EBSCO (1937 to 24 January 2018). The US National Institutes of Health Trials Registry (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. We searched the reference lists of relevant systematic reviews. SELECTION CRITERIA: We considered randomised controlled trials (RCTs) that evaluated any intervention for treating PEB, with male or female participants of any age, regardless of type of teeth (anterior or posterior, mandibular or maxillary). Trials could compare one type of intervention with another, with placebo, or with no treatment. DATA COLLECTION AND ANALYSIS: Three pairs of review authors independently screened search records. We obtained full papers for potentially relevant trials. If data had been extracted, we would have followed the methods described in the Cochrane Handbook for Systematic Reviews of Interventions for the statistical analysis. MAIN RESULTS: We did not find any randomised controlled trial suitable for inclusion in this review. AUTHORS' CONCLUSIONS: We were unable to identify any reports of randomised controlled trials that evaluated the effects of different interventions for the treatment of post-extraction bleeding. In view of the lack of reliable evidence on this topic, clinicians must use their clinical experience to determine the most appropriate means of treating this condition, depending on patient-related factors. There is a need for well designed and appropriately conducted clinical trials on this topic, which conform to the CONSORT statement (www.consort-statement.org/). FAU - Kumbargere Nagraj, Sumanth AU - Kumbargere Nagraj S AD - Department of Oral Medicine and Oral Radiology, Faculty of Dentistry, Melaka-Manipal Medical College (Manipal Academy of Higher Education), Jalan Batu Hampar, Bukit Baru, Melaka, Malaysia, 75150. FAU - Prashanti, Eachempati AU - Prashanti E FAU - Aggarwal, Himanshi AU - Aggarwal H FAU - Lingappa, Ashok AU - Lingappa A FAU - Muthu, Murugan S AU - Muthu MS FAU - Kiran Kumar Krishanappa, Salian AU - Kiran Kumar Krishanappa S FAU - Hassan, Haszelini AU - Hassan H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20180304 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2016 Jun 10;(6):CD011930. PMID: 27285450 MH - Female MH - Humans MH - Male MH - Oral Hemorrhage/etiology/*therapy MH - Postoperative Hemorrhage/etiology/*therapy MH - Tooth Extraction/*adverse effects PMC - PMC6494262 COIS- Sumanth Kumbargere Nagraj: no interests to declare
 Eachempati Prashanti: no interests to declare
 Himanshi Aggarwal: no interests to declare
 Ashok Lingappa: no interests to declare
 Murugan S Muthu: no interests to declare
 Salian Kiran Kumar Krishanappa: no interests to declare
 Haszelini Hassan: no interests to declare EDAT- 2018/03/05 06:00 MHDA- 2018/04/28 06:00 CRDT- 2018/03/05 06:00 PHST- 2018/03/05 06:00 [pubmed] PHST- 2018/04/28 06:00 [medline] PHST- 2018/03/05 06:00 [entrez] AID - CD011930.pub3 [pii] AID - 10.1002/14651858.CD011930.pub3 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2018 Mar 4;3(3):CD011930. doi: 10.1002/14651858.CD011930.pub3. PMID- 29171914 OWN - NLM STAT- MEDLINE DCOM- 20181001 LR - 20181202 IS - 1365-2842 (Electronic) IS - 0305-182X (Linking) VI - 45 IP - 3 DP - 2018 Mar TI - Risk of inferior alveolar nerve injury with coronectomy vs surgical extraction of mandibular third molars-A comparison of two techniques and review of the literature. PG - 250-257 LID - 10.1111/joor.12589 [doi] AB - The removal of mandibular third molar teeth is one of the most common oral surgical procedures. In a significant number of patients, it carries a degree of associated morbidity, including damage to the inferior alveolar nerve (IAN). For this reason, practitioners desire the most up-to-date guidance on the most appropriate technique, informed by the best available evidence that will produce the lowest incidence of iatrogenic complications. The aim of this study was to perform a systematic review comparing the effect of coronectomy vs complete surgical extraction of mandibular third molar teeth on the risk of IAN injury and other complications in adults. Studies were identified through Embase (1980-2016) and Ovid MEDLINE (1946-2016) database searches. Search terms included coronectomy, partial root removal, deliberate vital root retention, odontectomy, surgical removal, surgical extraction, complete tooth extraction and extract. Limits of the study included humans, English language and randomised controlled trials (RCTs). Only RCTs comparing IAN damage associated with surgical extraction of mandibular third molars vs coronectomy were included. From our database searches, we identified two unique RCTs matching the inclusion criteria. Both evaluated patients who had specific radiographic signs of intimate relationships with the IAN. Upon detailed analysis, the studies were noted to exhibit a high risk of bias in many categories, thereby rendering their results inconclusive. Although evidence from two RCTs suggests that coronectomy can reduce the risk of IAN injury compared to surgical removal of high-risk mandibular third molars, the quality of evidence is insufficient to provide definitive conclusions regarding the preferred technique. CI - © 2017 John Wiley & Sons Ltd. FAU - Ali, A S AU - Ali AS AD - Department of Oral and Maxillofacial Surgery, Division of Dentistry, University of Manchester, Manchester, UK. FAU - Benton, J A AU - Benton JA AD - Department of Oral and Maxillofacial Surgery, Division of Dentistry, University of Manchester, Manchester, UK. FAU - Yates, J M AU - Yates JM AUID- ORCID: 0000-0002-8187-023X AD - Department of Oral and Maxillofacial Surgery, Division of Dentistry, University of Manchester, Manchester, UK. LA - eng PT - Comparative Study PT - Journal Article PT - Review PT - Systematic Review DEP - 20171211 PL - England TA - J Oral Rehabil JT - Journal of oral rehabilitation JID - 0433604 SB - D SB - IM MH - Humans MH - Mandibular Nerve/physiopathology/*surgery MH - Molar, Third MH - Randomized Controlled Trials as Topic MH - Therapeutic Irrigation MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Trigeminal Nerve Injuries/*prevention & control MH - Wound Closure Techniques OTO - NOTNLM OT - coronectomy OT - nerve injury OT - surgical removal OT - third molars OT - wisdom teeth EDAT- 2017/11/25 06:00 MHDA- 2018/10/03 06:00 CRDT- 2017/11/25 06:00 PHST- 2017/11/15 00:00 [accepted] PHST- 2017/11/25 06:00 [pubmed] PHST- 2018/10/03 06:00 [medline] PHST- 2017/11/25 06:00 [entrez] AID - 10.1111/joor.12589 [doi] PST - ppublish SO - J Oral Rehabil. 2018 Mar;45(3):250-257. doi: 10.1111/joor.12589. Epub 2017 Dec 11. PMID- 25069437 OWN - NLM STAT- MEDLINE DCOM- 20150112 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 7 DP - 2014 Jul 29 TI - Surgical techniques for the removal of mandibular wisdom teeth. PG - CD004345 LID - 10.1002/14651858.CD004345.pub2 [doi] AB - BACKGROUND: The surgical removal of mandibular wisdom teeth is one of the most common operations undertaken in oral and maxillofacial surgery. The most common indication for surgery is infection about a partially erupted tooth that is impacted against bone or soft tissues. Other indications include unrestorable caries, pulpal and periapical pathology, fracture of the tooth and cyst development, amongst others. Most commonly the benefits of surgical removal of a wisdom tooth include alleviation of the symptoms and signs of pericoronitis and its potential consequences. However, surgery is frequently associated with postoperative pain, swelling and trismus. Less commonly complications include infection, including dry socket, trigeminal nerve injuries and rarely fracture of the mandible. OBJECTIVES: To compare the relative benefits and risks of different techniques for undertaking various aspects or stages of the surgical extraction of mandibular wisdom teeth. SEARCH METHODS: We searched the Cochrane Oral Health Group's Trials Register (to 21 March 2014), CENTRAL (The Cochrane Library 2014, Issue 1), MEDLINE (OVID) (1946 to 21 March 2014) and EMBASE (OVID) (1980 to 21 March 2014). We searched ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform for ongoing trials. There were no restrictions regarding language or date of publication in the electronic searches. SELECTION CRITERIA: RCTs comparing surgical techniques for removal of mandibular wisdom teeth. DATA COLLECTION AND ANALYSIS: Two review authors conducted assessment of relevance, risk of bias and data extraction. Study authors were contacted for additional information. RRs were used for dichotomous data and MDs for continuous data, unless the event rate was very low and Peto ORs were used. The pairing of the split-mouth studies was taken into account in the analysis for both dichotomous and continuous outcomes, and parallel group and split-mouth studies were combined using the generic inverse variance method. Random-effects models were used provided there were more than three studies (fixed-effect models otherwise). MAIN RESULTS: A total of 35 trials (2569 patients) were included. The interventions under consideration fell into seven broad categories, with many comparisons including only a small number of trials. Twenty-one of the trials were assessed at high risk of bias, the remaining 14 as unclear. The results are described in the summary of findings tables.Triangular flaps were associated with a 71% reduction in alveolar osteitis at one week (RR 0.29, 95% CI 0.11 to 0.78; three trials, moderate quality) and reduction in pain at 24 hours (MD -0.21, 95% CI -0.32 to -0.10; two trials, moderate quality) compared with envelope flaps. There was no evidence of a difference in overall infection rates, in maximum mouth opening or in permanent sensation. However, there was some evidence that residual swelling after one week was slightly increased in the triangular flap groups compared to envelope flap types (MD 0.66 mm, 95% CI 0.26 to 1.07; two trials, low quality). We found no data on temporary sensation, or adverse events.There was low quality evidence from two studies, looking at the use of a retractor during third molar surgery, to indicate more cases of temporary altered sensation (up to one month) when a retractor was used (Peto OR 5.19, 95% CI 1.38 to 19.49; two trials, low quality). One study reported that this did not persist for more than six months in either group. We found no data for use of a retractor on other primary outcomes or adverse effects (including fracture of the mandible).Due to the small number of studies, the different comparisons evaluated, the variable outcomes reported and the paucity of useful data for all primary outcomes we were not able to draw any conclusions concerning bone removal in third molar surgery.There was insufficient evidence from single studies of very low quality on irrigation method (manual versus mechanical) or irrigation volume (low or high) to determine whether there were differences or not for the outcomes of alveolar osteitis or postoperative infection. We found no data for any of the other primary outcomes.There was insufficient evidence (low to very low quality) that any wound closure technique (primary versus secondary) was superior to another for the outcomes of alveolar osteitis, postoperative infection or maximum mouth opening achieved after seven days, or reactionary bleeding. There was evidence that secondary wound closure was associated with reduced pain at 24 hours (MD 0.79, 95% CI 0.35 to 1.24; four trials, moderate quality) and slightly reduced swelling after one week (MD 0.33, 95% CI 0.09 to 0.57; seven trials, moderate quality).We found no data on other primary outcomes.There was some evidence that the use of a surgical drain was associated with less postoperative swelling (MD -0.90, 95% CI -1.62 to -0.19; five trials, moderate quality) and greater maximum mouth opening one week after surgery (MD 3.72 mm, 95% CI 2.84 to 4.59; two trials, moderate quality). There was insufficient evidence from a single study (low quality) to determine whether the presence of a drain made any difference to pain at 24 hours postoperation. There were no data for the other primary outcomes.Although two RCTs compared coronectomy with complete extraction, flaws in the design and the unit of analysis of these studies meant that there were no reliable data available for inclusion. AUTHORS' CONCLUSIONS: The thirty-five included trials looked at a range of different surgical techniques. The comparisons related to seven broad aspects of the surgical procedures for impacted mandibular third molars: type of surgical flap raised, use of retractors, techniques for bone removal, wound irrigation, wound closure, wound drainage, and complete/incomplete tooth removal. The quality of the body of evidence for each of these comparisons was very low to moderate due to the small number of trials and patients, and the majority of the trials being at high risk of bias (65%) with the remainder at unclear risk of bias.The evidence for making changes to surgical practice is therefore limited. However, it is useful to describe the state of the research evidence supporting practice so that surgeons can make an informed choice in adopting new techniques, or continuing with established techniques. FAU - Coulthard, Paul AU - Coulthard P AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Coupland III Building, Oxford Road, Manchester, UK, M13 9PL. FAU - Bailey, Edmund AU - Bailey E FAU - Esposito, Marco AU - Esposito M FAU - Furness, Susan AU - Furness S FAU - Renton, Tara F AU - Renton TF FAU - Worthington, Helen V AU - Worthington HV LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20140729 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UIN - Cochrane Database Syst Rev. 2020 Jul 26;7:CD004345. PMID: 32712962 MH - Drainage/methods MH - Humans MH - Mandible MH - Molar, Third/*surgery MH - Randomized Controlled Trials as Topic MH - Therapeutic Irrigation/methods MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/*surgery MH - Wound Closure Techniques EDAT- 2014/07/30 06:00 MHDA- 2015/01/13 06:00 CRDT- 2014/07/30 06:00 PHST- 2014/07/30 06:00 [entrez] PHST- 2014/07/30 06:00 [pubmed] PHST- 2015/01/13 06:00 [medline] AID - 10.1002/14651858.CD004345.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2014 Jul 29;(7):CD004345. doi: 10.1002/14651858.CD004345.pub2. PMID- 29963686 OWN - NLM STAT- MEDLINE DCOM- 20180921 LR - 20210109 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 7 IP - 7 DP - 2018 Jul 2 TI - Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions. PG - CD012293 LID - 10.1002/14651858.CD012293.pub2 [doi] LID - CD012293 AB - BACKGROUND: Individuals on continuous treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) are at increased risk of bleeding complications during and after oral or dental procedures. Anticoagulant treatment is preferably continued at the same dose, since dose reduction or discontinuation of treatment is associated with an increased risk of thromboembolism. The use of haemostatic measures during or after the procedure (or both) could enable continuation of the oral anticoagulant treatment. OBJECTIVES: We aimed to assess the efficacy of antifibrinolytic agents for preventing bleeding complications in people on oral anticoagulants undergoing minor oral surgery or dental extractions. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Coagulopathies Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles and reviews. We searched PubMed, Embase and the Cochrane Library. Additional searches were performed using ClinicalTrials.gov, the International Clinical Trials Registry Platform (ICTRP), the CINAHL database of nursing and allied health services, the open access ProQuest dissertation database, papers and reports from the American College of Clinical Pharmacy (ACCP) and abstract books from annual scientific conferences.Date of last search: 04 January 2018. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials in people on continuous treatment with VKAs or DOACs undergoing oral or dental procedures using antifibrinolytic agents (tranexamic acid (TXA) or epsilon aminocaproic acid) to prevent perioperative bleeding compared to no intervention or usual care with or without placebo. DATA COLLECTION AND ANALYSIS: Two authors independently screened the titles and abstracts of all identified articles. Full texts were obtained from potentially relevant abstracts and two authors independently assessed these for inclusion based of the selection criteria. A third author verified trial eligibility. Two authors independently performed data extraction and risk of bias assessments using standardized forms. The quality of the evidence was assessed using GRADE. MAIN RESULTS: No eligible trials in people on continuous treatment with DOACs undergoing oral or dental procedures were identified.Three randomised trials and one quasi-randomised trial (follow-up in all was seven days) in people on continuous treatment with VKAs were included with a total of 253 participants (mean age 60 years). Two trials published in 1989 and 1993 compared the antifibrinolytic agent TXA with placebo in people using VKAs. Two other trials were published in 1999 and 2015 and compared TXA with gelatin sponge and sutures, and dry gauze compression, respectively. In all included trials, those who were treated with VKAs had international normalised ratio (INR) values within the therapeutic range and TXA was applied locally, not systemically.The two trials from 1989 and 1993 comparing TXA with placebo showed a statistically significant beneficial effect regarding the number of major postoperative bleeding episodes requiring intervention, with a pooled risk difference (RD) of -0.25 (95% confidence interval (CI) -0.36 to -0.14) (128 participants) (moderate-quality evidence). For the two trials that compared TXA with either gelatin sponge and sutures or with dry gauze compression, there was no difference between the TXA and the standard care group, RD 0.02 (95% CI -0.07 to 0.11) (125 participants) (moderate-quality evidence). The combined RD of all included trials was -0.13 (95% CI -0.30 to 0.05) (moderate-quality evidence). There were no side effects of antifibrinolytic therapy that required treatment withdrawal (128 participants) (moderate-quality evidence). Despite heterogeneity between trials with respect to the different haemostatic measures used in the control groups, the trials were comparable regarding design and baseline participant characteristics.Overall, we considered the risk of bias to be low in the trials comparing TXA with placebo and moderate in the trials comparing TXA with alternative haemostatic measures. AUTHORS' CONCLUSIONS: Based on the results of this Cochrane Review, there seems to be a beneficial effect of locally applied TXA in preventing oral bleeding in people on continuous treatment with VKAs undergoing minor oral surgery or dental extractions. However, the small number of identified randomised controlled trials, the relatively small number of participants included in the trials and the differences in standard therapy and treatment regimens between trials, do not allow us to conclude definite efficacy of antifibrinolytic therapy in this population.We were unable to identify any eligible trials in people on continuous treatment with DOACs undergoing oral or dental procedures. Therefore, a beneficial effect of antifibrinolytic therapy can currently only be assumed based on data from the people using VKAs. FAU - Engelen, Eveline T AU - Engelen ET AD - University Medical Centre Utrecht, Poortstraat 95, Utrecht, Netherlands, 3572HG. FAU - Schutgens, Roger Eg AU - Schutgens RE FAU - Mauser-Bunschoten, Evelien P AU - Mauser-Bunschoten EP FAU - van Es, Robert Jj AU - van Es RJ FAU - van Galen, Karin Pm AU - van Galen KP LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20180702 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Anticoagulants) RN - 0 (Antifibrinolytic Agents) RN - 6T84R30KC1 (Tranexamic Acid) SB - IM UOF - doi: 10.1002/14651858.CD012293 MH - Anticoagulants/administration & dosage/*adverse effects MH - Antifibrinolytic Agents/*therapeutic use MH - Humans MH - Middle Aged MH - Minor Surgical Procedures/*adverse effects MH - Oral Hemorrhage/chemically induced/*prevention & control MH - Oral Surgical Procedures/*adverse effects MH - Tooth Extraction/adverse effects MH - Tranexamic Acid/*therapeutic use PMC - PMC6513563 COIS- There are no potential conflicts of interest for any of the authors. None of the authors have been involved in any of the included trials potentially eligible for inclusion in the review. EDAT- 2018/07/03 06:00 MHDA- 2018/09/22 06:00 CRDT- 2018/07/03 06:00 PHST- 2018/07/03 06:00 [pubmed] PHST- 2018/09/22 06:00 [medline] PHST- 2018/07/03 06:00 [entrez] AID - CD012293.pub2 [pii] AID - 10.1002/14651858.CD012293.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2018 Jul 2;7(7):CD012293. doi: 10.1002/14651858.CD012293.pub2. PMID- 30798949 OWN - NLM STAT- MEDLINE DCOM- 20191212 LR - 20191217 IS - 1943-4723 (Electronic) IS - 0002-8177 (Linking) VI - 150 IP - 4 DP - 2019 Apr TI - Cryotherapy in reducing pain, trismus, and facial swelling after third-molar surgery: Systematic review and meta-analysis of randomized clinical trials. PG - 269-277.e1 LID - S0002-8177(18)30787-6 [pii] LID - 10.1016/j.adaj.2018.11.008 [doi] AB - BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate the efficacy of cryotherapy in reducing pain, trismus, and facial swelling in patients undergoing third-molar surgery. TYPES OF STUDIES REVIEWED: The authors searched for randomized clinical trials in PubMed, Web of Science, SCOPUS, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Google Scholar, and OpenThesis. Eligibility criteria were population: patients submitted to removal of impacted third molars; intervention and comparison: postoperative cryotherapy versus no cold therapy; and outcomes: primary outcome was postoperative pain, and secondary outcomes were facial swelling and trismus. Eligible studies must have reported at least 1 of the outcomes of interest. After extracting data and assessing quality, the authors performed the meta-analyses. RESULTS: The authors included 6 studies in the quantitative synthesis analysis. Differences in pain intensity were found on postoperative day 2 (weighted mean difference, -0.72; 95% confidence interval, -1.45 to 0.01; P = .05) and postoperative day 3 (weighted mean difference, -0.36; 95% confidence interval, -0.59 to -0.13; P = .002). No evidence was found that cryotherapy was effective in reducing trismus and facial swelling. The quality of evidence was graded as low. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Evidence suggests that cryotherapy may have a small benefit in reducing pain after third-molar surgery, but it is not effective on facial swelling and trismus. Owing to the lack of standardization of cold application, effective evidence-based treatment protocols for cryotherapy after third-molar surgery still need to be established. CI - Copyright © 2019 American Dental Association. Published by Elsevier Inc. All rights reserved. FAU - do Nascimento-Júnior, Edmundo Marques AU - do Nascimento-Júnior EM FAU - Dos Santos, Gustavo Marques Sobral AU - Dos Santos GMS FAU - Tavares Mendes, Mário Luis AU - Tavares Mendes ML FAU - Cenci, Maximiliano AU - Cenci M FAU - Correa, Marcos Britto AU - Correa MB FAU - Pereira-Cenci, Tatiana AU - Pereira-Cenci T FAU - Martins-Filho, Paulo Ricardo Saquete AU - Martins-Filho PRS LA - eng PT - Journal Article PT - Meta-Analysis PT - Randomized Controlled Trial PT - Review PT - Systematic Review DEP - 20190222 PL - England TA - J Am Dent Assoc JT - Journal of the American Dental Association (1939) JID - 7503060 SB - D SB - IM MH - Cryotherapy MH - Edema MH - Humans MH - *Molar, Third MH - Pain, Postoperative MH - Randomized Controlled Trials as Topic MH - Tooth Extraction MH - *Tooth, Impacted MH - Trismus OTO - NOTNLM OT - *Cryotherapy OT - *oral surgery OT - *postoperative pain OT - *third molar EDAT- 2019/02/26 06:00 MHDA- 2019/12/18 06:00 CRDT- 2019/02/26 06:00 PHST- 2018/08/13 00:00 [received] PHST- 2018/11/02 00:00 [revised] PHST- 2018/11/07 00:00 [accepted] PHST- 2019/02/26 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/02/26 06:00 [entrez] AID - S0002-8177(18)30787-6 [pii] AID - 10.1016/j.adaj.2018.11.008 [doi] PST - ppublish SO - J Am Dent Assoc. 2019 Apr;150(4):269-277.e1. doi: 10.1016/j.adaj.2018.11.008. Epub 2019 Feb 22. PMID- 25890111 OWN - NLM STAT- MEDLINE DCOM- 20160108 LR - 20181202 IS - 1746-160X (Electronic) IS - 1746-160X (Linking) VI - 11 DP - 2015 Apr 10 TI - Coronectomy as a surgical approach to impacted mandibular third molars: a systematic review. PG - 9 LID - 10.1186/s13005-015-0068-7 [doi] LID - 9 AB - The aim of this systematic review was to evaluate the clinical effectiveness of the surgical technique of coronectomy for third molars extraction in close proximity with the inferior alveolar nerve.A literature survey carried out through PubMed, SCOPUS and the Cochrane Library from inceptions to the last access in January 31, 2014, was performed to intercept randomised clinical trials, controlled clinical trials, prospective cohort studies or retrospective studies (with or without control group) that examined the clinical outcomes after coronectomy. The following variable were evaluated: inferior alveolar nerve injury, lingual nerve injury, postoperative adverse effects, pulp disease, root migration and rate of reoperation. Ten articles qualified for the final analysis. The successful coronectomies varied from a minimum of 61.7% to a maximum of 100%. Coronectomy was associated with a low incidence of complications in terms of inferior alveolar nerve injury (0%-9.5%), lingual nerve injury (0%-2%), postoperative pain (1.1%-41.9%) and swelling (4.6%), dry socket infection (2%-12%), infection rate (1%-9.5%) and pulp disease (0.9%). Migration of the retained roots seems to be a frequent occurrence (2%-85.3%).Coronectomy appears to be a safe procedure at least in the short term, with a reduced incidence of postoperative complications. Therefore, a coronectomy can be indicated for teeth that are very close to the inferior alveolar nerve. If a second operation is needed for the remnant roots, they can be removed with a low risk of paresthesia, because the roots are generally receded from the mandubular nerve. FAU - Martin, Andrea AU - Martin A AD - Unit of Oral Surgery, School of Dental Sciences, University of Trieste, Trieste, Italy. andrea.martin@hotmail.it. FAU - Perinetti, Giuseppe AU - Perinetti G AD - Unit of Oral Surgery, School of Dental Sciences, University of Trieste, Trieste, Italy. g.perinetti@fmc.units.it. FAU - Costantinides, Fulvia AU - Costantinides F AD - Unit of Oral Surgery, School of Dental Sciences, University of Trieste, Trieste, Italy. f.costantinides@fmc.units.it. FAU - Maglione, Michele AU - Maglione M AD - Unit of Oral Surgery, School of Dental Sciences, University of Trieste, Trieste, Italy. m.maglione@fmc.units.it. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20150410 TA - Head Face Med JT - Head & face medicine JID - 101245792 SB - D SB - IM MH - Cone-Beam Computed Tomography/methods MH - Cranial Nerve Injuries/etiology/*prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/surgery MH - Mandibular Nerve MH - Molar, Third/diagnostic imaging/physiopathology/*surgery MH - Pain, Postoperative/physiopathology MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Retrospective Studies MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/diagnostic imaging/*surgery MH - Treatment Outcome PMC - PMC4397866 EDAT- 2015/04/19 06:00 MHDA- 2016/01/09 06:00 CRDT- 2015/04/19 06:00 PHST- 2014/11/21 00:00 [received] PHST- 2015/03/11 00:00 [accepted] PHST- 2015/04/19 06:00 [entrez] PHST- 2015/04/19 06:00 [pubmed] PHST- 2016/01/09 06:00 [medline] AID - 10.1186/s13005-015-0068-7 [pii] AID - 68 [pii] AID - 10.1186/s13005-015-0068-7 [doi] PST - epublish SO - Head Face Med. 2015 Apr 10;11:9. doi: 10.1186/s13005-015-0068-7. PMID- 28338025 OWN - NLM STAT- MEDLINE DCOM- 20180305 LR - 20181113 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 18 IP - 1 DP - 2017 Mar TI - Preventing perioperative bleeding in patients with inherited bleeding disorders. PG - 28-29 LID - 10.1038/sj.ebd.6401226 [doi] AB - Data sourcesCochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, a regularly updated database informed by trials identified within electronic databases including MEDLINE. Further defined searches were undertaken in PubMed, Embase, The Cochrane Library, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. Additional hand searching of relevant journals and books of conference proceedings was undertaken.Study selectionRandomised and quasi-randomised controlled trials in people of all ages with haemophilia or VWD undergoing oral or dental procedures using antifibrinolytic agents (tranexamic acid (TXA) or epsilon aminocaproic acid (EACA)) to prevent perioperative bleeding compared to no intervention with or without placebo.Data extraction and synthesisTwo authors independently assessed identified publications for inclusion based on defined selection criteria. The two authors performed data extraction and risk of bias assessments using standardised forms and the Cochrane risk of bias tools. A third author, deemed to have particular subject expertise, verified eligibility of inclusion.ResultsOne randomised, double-blinded placebo controlled trial and one quasi-randomised trial were included. A total of 59 participants with haemophilia undergoing dental extraction were involved. Both trials evidenced a notable reduction in post-operative bleeding following dental extraction when either TXA or EACA were used, in addition to routine preoperative factor replacement, when compared to placebo. The number of post-operative bleeds, amount of blood loss and the need for additional clotting factors were reduced in the groups receiving antifibrinolytic therapy. No eligible trials in people with VWD were identified.ConclusionsLow quality evidence exists to support the use of adjuvant antifibrinolytic therapy to reduce perioperative bleeding in patients with haemophilia undergoing dental extraction. The limited number of trials identified (N=2), minimal sample size (N=28, N=31) and historic nature of the studies, originating from the 1970s, in addition to study heterogeneity and subsequent selection bias results in a low quality evidence grade for recommending adjuvant antifibrinolytic therapy. There is no clear indication to alter current practice utilising antifibrinolytic therapy to manage patients with haemophilia undergoing dental surgery in accordance with internationally accepted guidelines. However, further research with standardised study deigns would be welcomed in order to enhance the evidence base in the management of people with haemophilia and VWD. FAU - Watterson, Colin AU - Watterson C AD - Special Care Dentistry, Public Dental Service, NHS Lothian, Edinburgh, Scotland. FAU - Beacher, Nicholas AU - Beacher N AD - School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, Scotland. LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Antifibrinolytic Agents) RN - 6T84R30KC1 (Tranexamic Acid) RN - U6F3787206 (Aminocaproic Acid) SB - D SB - IM MH - Aminocaproic Acid/*therapeutic use MH - Antifibrinolytic Agents/*therapeutic use MH - Blood Loss, Surgical/*prevention & control MH - Hemophilia A/*complications MH - Humans MH - Postoperative Hemorrhage/*drug therapy/*etiology MH - Tooth Extraction/*adverse effects MH - Tranexamic Acid/*therapeutic use EDAT- 2017/03/25 06:00 MHDA- 2018/03/06 06:00 CRDT- 2017/03/25 06:00 PHST- 2017/03/25 06:00 [entrez] PHST- 2017/03/25 06:00 [pubmed] PHST- 2018/03/06 06:00 [medline] AID - 6401226 [pii] AID - 10.1038/sj.ebd.6401226 [doi] PST - ppublish SO - Evid Based Dent. 2017 Mar;18(1):28-29. doi: 10.1038/sj.ebd.6401226. PMID- 27287853 OWN - NLM STAT- MEDLINE DCOM- 20170912 LR - 20181202 IS - 1865-8652 (Electronic) IS - 0741-238X (Print) IS - 0741-238X (Linking) VI - 33 IP - 7 DP - 2016 Jul TI - Do Corticosteroids Still Have a Role in the Management of Third Molar Surgery? PG - 1105-39 LID - 10.1007/s12325-016-0357-y [doi] AB - INTRODUCTION: The use of corticosteroids to reduce the post-operative sequelae of lower third molar surgery, namely pain, swelling and trismus, has been well studied by many researchers over the past 6 decades. This study reviewed the reported outcome of corticosteroids used in controlling the above sequalae after third molar surgery. MATERIALS AND METHODS: A PubMed, Medline, EMBASE and Google search was undertaken of all controlled clinical trials on the effects of corticosteroids on pain, swelling and trismus after lower third molar surgery. The review was limited to studies published over the last 10 years (2006-2015). RESULTS: Of the 46 initially retrieved articles, 34 were finally included. Eleven studies compared the effect of 2 similar (but different dose) or different group of corticosteroids. Thirty-one studies reported the effects of corticosteroids on all sequale, 2 reported the outcome on swelling and trismus and another 1 on swelling and pain only. In 16 of the studies, corticosteroid use resulted in significant reductions in pain after third molar removal. Twenty-two out of 29 studies reported reduced swelling against negative control while 18 out of 25 studies reported improved mouth opening. Fourteen studies reported the benefit of corticosteroids on all 3 sequelae, with 71.4% resulted from the use of methylprednisolone. CONCLUSION: Although there are some conflicting effects, the results of this analysis shows in general the benefits derived from short-term use of corticosteroids in relation to pain, swelling and trismus following third molar surgical extraction, with no side effects observed. FUNDING: This work was supported by the University of Malaya's High Impact Research grant UM.C/625/1/HIR/MOHE/05. FAU - Ngeow, Wei Cheong AU - Ngeow WC AD - Department of Oro-Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia. ngeowy@um.edu.my. AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, University of California, San Francisco, 533 Parnassus Avenue, UB08, San Francisco, CA, 94143-0440, USA. ngeowy@um.edu.my. FAU - Lim, Daniel AU - Lim D AD - Department of Oro-Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20160610 TA - Adv Ther JT - Advances in therapy JID - 8611864 RN - 0 (Adrenal Cortex Hormones) SB - T MH - Adrenal Cortex Hormones/*administration & dosage MH - Edema/*prevention & control MH - Humans MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Postoperative Complications/*prevention & control MH - Tooth Extraction/methods MH - Trismus/*prevention & control PMC - PMC4939150 OTO - NOTNLM OT - *Corticosteroids OT - *Pain OT - *Surgery OT - *Swelling OT - *Third molar OT - *Trismus EDAT- 2016/06/12 06:00 MHDA- 2017/09/13 06:00 CRDT- 2016/06/12 06:00 PHST- 2016/04/19 00:00 [received] PHST- 2016/06/12 06:00 [entrez] PHST- 2016/06/12 06:00 [pubmed] PHST- 2017/09/13 06:00 [medline] AID - 10.1007/s12325-016-0357-y [pii] AID - 357 [pii] AID - 10.1007/s12325-016-0357-y [doi] PST - ppublish SO - Adv Ther. 2016 Jul;33(7):1105-39. doi: 10.1007/s12325-016-0357-y. Epub 2016 Jun 10. PMID- 31669068 OWN - NLM STAT- MEDLINE DCOM- 20200303 LR - 20200303 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 57 IP - 10 DP - 2019 Dec TI - Tranexamic acid to reduce bleeding after dental extraction in patients treated with non-vitamin K oral anticoagulants: design and rationale of the EXTRACT-NOAC trial. PG - 1107-1112 LID - S0266-4356(19)30692-8 [pii] LID - 10.1016/j.bjoms.2019.10.297 [doi] AB - Bleeding after dental extraction in patients treated with non-vitamin K oral anticoagulants (NOAC) may lead to unplanned reinterventions and interruption of anticoagulation, thereby exposing patients to a risk of thromboembolism. We have designed a study (EXTRACT-NOAC) to investigate whether tranexamic acid (TXA) mouthwash decreases bleeding after extraction in such patients. The study is a randomised, double-blind, placebo-controlled trial. We plan to randomise 236 patients listed for dental extraction and treated with NOAC to 10% TXA mouthwash or placebo. Patients are instructed to use the mouthwash before the dental extraction, and three times a day for three days thereafter. The primary outcome is oral bleeding. Secondary outcomes include type of bleeding, procedural bleeding score, number of reinterventions after oral bleeding, and number of interruptions in NOAC treatment. Any bleeding from sources other than the mouth, and thrombotic events, are recorded as safety outcomes. Patients are followed-up for seven days. This study will provide evidence to guide the management of patients taking NOAC who need teeth extracted. CI - Copyright © 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Ockerman, A AU - Ockerman A AD - Oral and Maxillofacial Surgery - Imaging and Pathology research group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven and Department of Oral & Maxillofacial Surgery, University of Leuven, Leuven, Belgium. Electronic address: anna.ockerman@kuleuven.be. FAU - Vanhaverbeke, M AU - Vanhaverbeke M AD - Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. FAU - Miclotte, I AU - Miclotte I AD - Department of Oral & Maxillofacial Surgery, University of Leuven, Leuven, Belgium. FAU - Belmans, A AU - Belmans A AD - Leuven Biostatistics and Statistical Bioinformatics Centre, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium. FAU - Vanassche, T AU - Vanassche T AD - Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. FAU - Politis, C AU - Politis C AD - Department of Oral & Maxillofacial Surgery, University of Leuven, Leuven, Belgium. FAU - Jacobs, R AU - Jacobs R AD - Oral and Maxillofacial Surgery - Imaging and Pathology research group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven and Department of Oral & Maxillofacial Surgery, University of Leuven, Leuven, Belgium; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Verhamme, P AU - Verhamme P AD - Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20191025 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anticoagulants) RN - 12001-79-5 (Vitamin K) RN - 6T84R30KC1 (Tranexamic Acid) SB - D SB - IM MH - Administration, Oral MH - *Anticoagulants/therapeutic use MH - Double-Blind Method MH - Humans MH - *Postoperative Hemorrhage/prevention & control MH - *Thromboembolism/prevention & control MH - *Tooth Extraction/adverse effects MH - *Tranexamic Acid/therapeutic use MH - *Vitamin K OTO - NOTNLM OT - *Bleeding OT - *Dental extraction OT - *Non-vitamin K oral anticoagulants OT - *Tranexamic acid EDAT- 2019/11/02 06:00 MHDA- 2020/03/04 06:00 CRDT- 2019/11/01 06:00 PHST- 2019/02/07 00:00 [received] PHST- 2019/10/04 00:00 [accepted] PHST- 2019/11/02 06:00 [pubmed] PHST- 2020/03/04 06:00 [medline] PHST- 2019/11/01 06:00 [entrez] AID - S0266-4356(19)30692-8 [pii] AID - 10.1016/j.bjoms.2019.10.297 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2019 Dec;57(10):1107-1112. doi: 10.1016/j.bjoms.2019.10.297. Epub 2019 Oct 25. PMID- 27578151 OWN - NLM STAT- MEDLINE DCOM- 20161020 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 8 DP - 2016 Aug 31 TI - Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. PG - CD003879 LID - 10.1002/14651858.CD003879.pub4 [doi] AB - BACKGROUND: Prophylactic removal of asymptomatic disease-free impacted wisdom teeth is surgical removal of wisdom teeth in the absence of symptoms and with no evidence of local disease. Impacted wisdom teeth may be associated with pathological changes, such as pericoronitis, root resorption, gum and alveolar bone disease (periodontitis), caries and the development of cysts and tumours. When surgical removal is carried out in older people, the risk of postoperative complications, pain and discomfort is increased. Other reasons to justify prophylactic removal of asymptomatic disease-free impacted third molars have included preventing late lower incisor crowding, preventing damage to adjacent structures such as the second molar or the inferior alveolar nerve, in preparation for orthognathic surgery, in preparation for radiotherapy or during procedures to treat people with trauma to the affected area. Removal of asymptomatic disease-free wisdom teeth is a common procedure, and researchers must determine whether evidence supports this practice. This review is an update of an existing review published in 2012. OBJECTIVES: To evaluate the effects of removal compared with retention (conservative management) of asymptomatic disease-free impacted wisdom teeth in adolescents and adults. SEARCH METHODS: We searched the following electronic databases: Cochrane Oral Health's Trials Register (to 24 May 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (2016, Issue 4), MEDLINE Ovid (1946 to 24 May 2016) and Embase Ovid (1980 to 24 May 2016). We searched ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform for ongoing and unpublished studies to 24 May 2016. We imposed no restrictions on language or date of publication in our search of electronic databases. SELECTION CRITERIA: Studies comparing removal (or absence) with retention (or presence) of asymptomatic disease-free impacted wisdom teeth in adolescents or adults. We included randomised controlled trials (RCTs) with no restriction on length of follow-up, if available. We considered quasi-RCTs and prospective cohort studies for inclusion if investigators measured outcomes with follow-up of five years or longer. DATA COLLECTION AND ANALYSIS: Eight review authors screened search results and assessed the eligibility of studies for inclusion according to the review inclusion criteria. Eight review authors independently conducted risk of bias assessments in duplicate. When information was unclear, we contacted study authors for additional information. MAIN RESULTS: This review includes two studies. The previous review included one RCT with a parallel-group design, which was conducted in a dental hospital setting in the United Kingdom; our new search for this update identified one prospective cohort study conducted in the private sector in the USA. Primary outcome No eligible studies in this review reported the effects of removal compared with retention of asymptomatic disease-free impacted wisdom teeth on health-related quality of life Secondary outcomes We found only low to very low quality evidence of the effects of removal compared with retention of asymptomatic disease-free impacted wisdom teeth for a limited number of secondary outcome measures.One prospective cohort study, reporting data from a subgroup of 416 healthy male participants, aged 24 to 84 years, compared the effect of the absence (previous removal or agenesis) against the presence of asymptomatic disease-free impacted wisdom teeth on periodontitis and caries associated with the distal of the adjacent second molar during a follow-up period of three to over 25 years. Very low quality evidence suggests that the presence of asymptomatic disease-free impacted wisdom teeth may be associated with increased risk of periodontitis affecting the adjacent second molar in the long term. In the same study, which is at serious risk of bias, there is insufficient evidence to demonstrate a difference in caries risk associated with the presence or absence of impacted wisdom teeth.One RCT with 164 randomised and 77 analysed adolescent participants compared the effect of extraction with retention of asymptomatic disease-free impacted wisdom teeth on dimensional changes in the dental arch after five years. Participants (55% female) had previously undergone orthodontic treatment and had 'crowded' wisdom teeth. No evidence from this study, which was at high risk of bias, was found to suggest that removal of asymptomatic disease-free impacted wisdom teeth has a clinically significant effect on dimensional changes in the dental arch.The included studies did not measure our other secondary outcomes: costs, other adverse events associated with retention of asymptomatic disease-free impacted wisdom teeth (pericoronitis, root resorption, cyst formation, tumour formation, inflammation/infection) and adverse effects associated with their removal (alveolar osteitis/postoperative infection, nerve injury, damage to adjacent teeth during surgery, bleeding, osteonecrosis related to medication/radiotherapy, inflammation/infection). AUTHORS' CONCLUSIONS: Insufficient evidence is available to determine whether or not asymptomatic disease-free impacted wisdom teeth should be removed. Although asymptomatic disease-free impacted wisdom teeth may be associated with increased risk of periodontitis affecting adjacent second molars in the long term, the evidence is of very low quality. Well-designed RCTs investigating long-term and rare effects of retention and removal of asymptomatic disease-free impacted wisdom teeth, in a representative group of individuals, are unlikely to be feasible. In their continuing absence, high quality, long-term prospective cohort studies may provide valuable evidence in the future. Given the lack of available evidence, patient values should be considered and clinical expertise used to guide shared decision making with patients who have asymptomatic disease-free impacted wisdom teeth. If the decision is made to retain asymptomatic disease-free impacted wisdom teeth, clinical assessment at regular intervals to prevent undesirable outcomes is advisable. FAU - Ghaeminia, Hossein AU - Ghaeminia H AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein Zuid 14, Nijmegen, Netherlands, 6525 GA. FAU - Perry, John AU - Perry J FAU - Nienhuijs, Marloes E L AU - Nienhuijs ME FAU - Toedtling, Verena AU - Toedtling V FAU - Tummers, Marcia AU - Tummers M FAU - Hoppenreijs, Theo J M AU - Hoppenreijs TJ FAU - Van der Sanden, Wil J M AU - Van der Sanden WJ FAU - Mettes, Theodorus G AU - Mettes TG LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20160831 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2012;(6):CD003879. PMID: 22696337 UIN - Cochrane Database Syst Rev. 2020 May 4;5:CD003879. PMID: 32368796 MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Asymptomatic Diseases MH - Humans MH - Middle Aged MH - Molar, Third/*surgery MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Watchful Waiting EDAT- 2016/09/01 06:00 MHDA- 2016/10/21 06:00 CRDT- 2016/09/01 06:00 PHST- 2016/09/01 06:00 [entrez] PHST- 2016/09/01 06:00 [pubmed] PHST- 2016/10/21 06:00 [medline] AID - 10.1002/14651858.CD003879.pub4 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2016 Aug 31;(8):CD003879. doi: 10.1002/14651858.CD003879.pub4. PMID- 31002742 OWN - NLM STAT- MEDLINE DCOM- 20190528 LR - 20200511 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 4 IP - 4 DP - 2019 Apr 19 TI - Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. PG - CD011385 LID - 10.1002/14651858.CD011385.pub3 [doi] LID - CD011385 AB - BACKGROUND: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. However, a systematic review of trials reporting outcomes after oral surgery or a dental procedure in people with an inherited bleeding disorder, with or without, the use of antifibrinolytic agents has not been performed to date. This is an update of a previously published Cochrane Review. OBJECTIVES: Primarily, we aim to assess the efficacy of antifibrinolytic agents to prevent bleeding complications in people with haemophilia or VWD undergoing oral or dental procedures.Secondary objectives are to assess if antifibrinolytic agents can replace or reduce the need for clotting factor concentrate therapy in people with haemophilia or VWD and to establish the effects of these agents on bleeding in oral or dental procedures for each of these patient populations. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, compiled from electronic database searches of the Cochrane Central Register of Controlled Trials (CENTRAL), of MEDLINE and from handsearching of journals and conference abstract books. We additionally searched the reference lists of relevant articles and reviews. We searched PubMed, Embase, Cinahl and the Cochrane Library. Additional searches were performed in ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP).Date of last search of the Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register: 01 March 2019. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials in people with haemophilia or VWD undergoing oral or dental procedures using antifibrinolytic agents (tranexamic acid or epsilon aminocaproic acid (EACA)) to prevent perioperative bleeding compared to no intervention or usual care with or without placebo. DATA COLLECTION AND ANALYSIS: Two authors independently screened the titles and abstracts of all identified articles. Full texts were obtained for potentially relevant abstracts and two authors independently assessed these for inclusion based on the selection criteria. A third author verified trial eligibility. Two authors independently performed data extraction and risk of bias assessments using standardised forms. MAIN RESULTS: While there were no eligible trials in people with VWD identified, two randomised, double-blind, placebo-controlled trials (total of 59 participants) in people with haemophilia undergoing dental extraction were included. One trial of tranexamic acid published in 1972 included 28 participants with mild, moderate or severe haemophilia A and B and one of EACA published in 1971 included 31 people with haemophilia with factor VIII or factor IX levels less than 15%. Overall, the two included trials showed a beneficial effect of tranexamic acid and EACA, administered systemically, in reducing the number of bleedings, the amount of blood loss and the need for therapeutic clotting factor concentrates. Regarding postoperative bleeding, the tranexamic acid trial showed a risk difference (RD) of -0.64 (95% confidence interval (CI) -0.93 to - 0.36) and the EACA trial a RD of -0.50 (95% CI 0.77 to -0.22). The combined RD of both trials was -0.57 (95% CI -0.76 to -0.37), with the quality of the evidence (GRADE) for this outcome is rated as moderate. Side effects occurred once and required stopping EACA (combined RD of -0.03 (95% CI -0.08 to 0.13). There was heterogeneity between the two trials regarding the proportion of people with severe haemophilia included, the concomitant standard therapy and fibrinolytic agent treatment regimens used. We cannot exclude that a selection bias has occurred in the EACA trial, but overall the risk of bias appeared to be low for both trials. AUTHORS' CONCLUSIONS: Despite the discovery of a beneficial effect of systemically administered tranexamic acid and EACA in preventing postoperative bleeding in people with haemophilia undergoing dental extraction, the limited number of randomised controlled trials identified, in combination with the small sample sizes and heterogeneity regarding standard therapy and treatment regimens between the two trials, do not allow us to conclude definite efficacy of antifibrinolytic therapy in oral or dental procedures in people with haemophilia. No trials were identified in people with VWD. FAU - van Galen, Karin Pm AU - van Galen KP AD - Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT. FAU - Engelen, Eveline T AU - Engelen ET FAU - Mauser-Bunschoten, Evelien P AU - Mauser-Bunschoten EP FAU - van Es, Robert Jj AU - van Es RJ FAU - Schutgens, Roger Eg AU - Schutgens RE LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20190419 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Antifibrinolytic Agents) SB - IM UOF - Cochrane Database Syst Rev. 2015 Dec 24;(12):CD011385. PMID: 26704192 MH - Antifibrinolytic Agents/*therapeutic use MH - Hemophilia A/*complications/drug therapy MH - Humans MH - Minor Surgical Procedures/adverse effects MH - Oral Hemorrhage/*prevention & control MH - Postoperative Hemorrhage/prevention & control MH - Surgery, Oral MH - Tooth Extraction/adverse effects MH - von Willebrand Diseases/*complications PMC - PMC6474399 COIS- Karin PM van Galen: none known. Eveline T Engelen: none known. Evelien Mauser‐Bunschoten: in my opinion there will be no conflict of interest. Full disclosure ‐ I have provided expert opinion to Baxter and my institution has received payments from Sanquin, NovoNordisk, Bayer, Baxter, Pfizer, Griffols for lectures I have given. My institution has also received funding in relation to a twinning program in Indonesia and education and cooperation with Indonesian haemophilia centers. Robert JJ van Es: none known. Roger EG Schutgens: I have no conflicts of interest to declare. Full disclosure ‐ I have provided consultancy to Bayer on new products for hemophilia and ADVANCE working group on behalf of my institution. My institution has received grants from Novo Nordisk for a project 'Project cartilage damage in hemophilia' and from Bayer for a project 'Triumph trial, immunotherapy in hemophilia'. My institution has also received payment from Biotest and Bayer for lectures I have given at hemophilia conferences. EDAT- 2019/04/20 06:00 MHDA- 2019/05/29 06:00 CRDT- 2019/04/20 06:00 PHST- 2019/04/20 06:00 [pubmed] PHST- 2019/05/29 06:00 [medline] PHST- 2019/04/20 06:00 [entrez] AID - CD011385.pub3 [pii] AID - 10.1002/14651858.CD011385.pub3 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2019 Apr 19;4(4):CD011385. doi: 10.1002/14651858.CD011385.pub3. PMID- 30975961 OWN - NLM STAT- MEDLINE DCOM- 20190419 LR - 20190419 IS - 1119-3077 (Print) VI - 22 IP - 4 DP - 2019 Apr TI - Comparison of the effect of advanced platelet-rich fibrin and leukocyte- and platelet-rich fibrin on outcomes after removal of impacted mandibular third molar: A randomized split-mouth study. PG - 546-552 LID - 10.4103/njcp.njcp_473_18 [doi] AB - AIM: In this study, it was aimed to investigate and compare the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling, and trismus after mandibular third molar surgery. SUBJECTS AND METHODS: The study included a total of 27 patients with bilateral impacted mandibular third molar, which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first and second group, A-PRF and L-PRF were applied into the tooth socket, respectively. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. STATISTICAL ANALYSIS USED: The data were collected and analyzed with unpaired Student's t-test and Mann-Whitney U test. RESULTS: The study was conducted with 27 patients, consisting of 15 females and 12 males between ages of 18-26. The visual analog scale pain scores of the L-PRF group during first (P < 0.05), second, and third days and total values (P < 0.01); the number of analgesics on days 2 (P < 0.01) and 3; and their total values (P < 0.05) were significantly higher than the A-PRF group. There was no significant difference between swelling, trismus, and the duration of operation (P > 0.05). CONCLUSION: The results of this study showed that the use of A-PRF after mandibular third molar extraction significantly reduces postoperative pain and the patients need to take analgesics of A-PRF group compared to L-PRF group. FAU - Caymaz, M G AU - Caymaz MG AD - Department of Oral and Maxillofacial Surgery, Near East University Faculty of Dentistry, Nicosia, Mersin-10, Turkey. FAU - Uyanik, L O AU - Uyanik LO AD - Department of Oral and Maxillofacial Surgery, Near East University Faculty of Dentistry, Nicosia, Mersin-10, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 RN - 9001-31-4 (Fibrin) SB - IM MH - Adult MH - Edema/*drug therapy/etiology MH - Female MH - Fibrin/*therapeutic use MH - Humans MH - *Leukocytes MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - *Platelet-Rich Fibrin MH - Postoperative Period MH - Tooth Extraction/*adverse effects/methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/*drug therapy MH - Turkey MH - Young Adult OTO - NOTNLM OT - Advanced platelet rich fibrin OT - impacted third molar surgery OT - leukocyte- and platelet rich fibrin COIS- None EDAT- 2019/04/13 06:00 MHDA- 2019/04/20 06:00 CRDT- 2019/04/13 06:00 PHST- 2019/04/13 06:00 [entrez] PHST- 2019/04/13 06:00 [pubmed] PHST- 2019/04/20 06:00 [medline] AID - NigerJClinPract_2019_22_4_546_255931 [pii] AID - 10.4103/njcp.njcp_473_18 [doi] PST - ppublish SO - Niger J Clin Pract. 2019 Apr;22(4):546-552. doi: 10.4103/njcp.njcp_473_18. PMID- 30917605 OWN - NLM STAT- MEDLINE DCOM- 20191001 LR - 20200225 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 55 IP - 3 DP - 2019 Mar 26 TI - How to Manage Impacted Third Molars: Germectomy or Delayed Removal? A Systematic Literature Review. LID - 10.3390/medicina55030079 [doi] LID - 79 AB - OBJECTIVES: The aim of this systematic review is to evaluate and compare the risks and benefits of germectomy and delayed removal of third molars and develop a patient management algorithm for second molar eruption in syndrome/incompliant patients. MATERIALS AND METHODS: A literature search was performed in the following databases; the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Scopus, and Web of Science. Last search was done on July 2nd, 2018 including articles published from the last 18 years. The search aimed to identify all relevant studies written in English language. Gray literature was excluded. Risk of bias was evaluated with specific predetermined criteria. This systematic literature review was reported according to the PRISMA-P statement and was registered in the PROSPERO database with the following protocol ID: 104261. RESULTS: Literature search war performed on July 2018 and updated on February 2019. A total of 1610 articles were screened. After abstract screening and discarding duplicates, 86 full-text articles were obtained and subjected to additional evaluation. Four articles were included in the review. Three studies were considered as having a medium risk of bias and one was assessed as at high risk. Due to the heterogeneity of presenting results and a very low number of included studies a quantitative analysis was not possible. Only qualitative analysis was made. Considering the limited number of studies included and the level of risk of bias there is no sufficient evidence to state the benefits of preventive removal of impacted third molars, especially in patients with poor oral hygiene due to intellectual disability. Early germectomy represents an elective approach of pathologic alteration of tooth germ; orthodontic issues meet appropriate indication for a delayed removal. CONCLUSIONS: Given the best evidence-based information regarding patients' medical condition, we highlight the need to provide an ethical-based comprehensive approach in the diagnostic workflow and the assessment of treatment outcome. FAU - Staderini, Edoardo AU - Staderini E AD - Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Dentistry and Maxillofacial Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. edoardo.staderini@yahoo.it. FAU - Patini, Romeo AU - Patini R AD - Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Dentistry and Maxillofacial Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. romeo.patini@unicatt.it. FAU - Guglielmi, Federica AU - Guglielmi F AD - Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Dentistry and Maxillofacial Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. fe.guglielmi@gmail.com. FAU - Camodeca, Andrea AU - Camodeca A AD - Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Dentistry and Maxillofacial Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. andrecamo@tiscali.it. FAU - Gallenzi, Patrizia AU - Gallenzi P AD - Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Dentistry and Maxillofacial Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. patrizia.gallenzi@unicatt.it. LA - eng PT - Journal Article PT - Systematic Review DEP - 20190326 TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Adolescent MH - Anesthesia, General/adverse effects MH - Child MH - Data Mining MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Molar, Third/*pathology/*surgery MH - Oral Hygiene MH - Postoperative Complications MH - PubMed MH - Time-to-Treatment MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery PMC - PMC6473914 OTO - NOTNLM OT - complications OT - dental impaction OT - oral surgery OT - orthodontics OT - systematic review OT - third molar germs COIS- The authors declare no conflicts of interest. EDAT- 2019/03/29 06:00 MHDA- 2019/10/02 06:00 CRDT- 2019/03/29 06:00 PHST- 2019/02/28 00:00 [received] PHST- 2019/03/05 00:00 [revised] PHST- 2019/03/22 00:00 [accepted] PHST- 2019/03/29 06:00 [entrez] PHST- 2019/03/29 06:00 [pubmed] PHST- 2019/10/02 06:00 [medline] AID - medicina55030079 [pii] AID - medicina-55-00079 [pii] AID - 10.3390/medicina55030079 [doi] PST - epublish SO - Medicina (Kaunas). 2019 Mar 26;55(3):79. doi: 10.3390/medicina55030079. PMID- 29629438 OWN - NLM STAT- MEDLINE DCOM- 20190307 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 49 IP - 5 DP - 2018 TI - Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: A split-mouth randomized clinical trial. PG - 377-388 LID - 10.3290/j.qi.a40113 [doi] AB - OBJECTIVES: The purpose of this study was to evaluate the influence of leukocyte- and platelet-rich fibrin (L-PRF) on impacted mandibular third molar (IMTM) extraction wound healing, patient postoperative discomfort, and incidence of alveolar osteitis. METHOD AND MATERIALS: Thirty-four patients (20 female, 14 male) who met the inclusion criteria for this split-mouth randomized clinical trial were enrolled and 30 patients completed the study. Patients were randomized and underwent bilateral IMTM surgical extractions. Following extraction, one socket randomly received L-PRF, and the other socket served as a regular blood clot control. Postoperatively, the soft tissue healing index (HI), pain according to visual analog scale (VAS), facial swelling using a horizontal and vertical guide, and incidence of alveolar osteitis were evaluated 1, 3, 7, and 14 days after surgery. RESULTS: Sites treated with L-PRF resulted in improved HI (P = .001) and lower pain VAS scores (P = .001) in the first postoperative week. Significant reduction of facial swelling was recorded on first (P = .035) and third (P = .023) postoperative days in L-PRF sites versus controls, ceasing to nonsignificant difference at day 7 (P = .224). None of the L-PRF sites and four control sites were affected by alveolar osteitis (P = .001). CONCLUSION: Within the limitations of this split-mouth study, L-PRF improved soft tissue healing and reduced postoperative pain, swelling, and incidence of alveolar osteitis after IMTM surgical extractions. FAU - Daugela, Povilas AU - Daugela P FAU - Grimuta, Vaidas AU - Grimuta V FAU - Sakavicius, Dalius AU - Sakavicius D FAU - Jonaitis, Juozas AU - Jonaitis J FAU - Juodzbalys, Gintaras AU - Juodzbalys G LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Dry Socket/prevention & control MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Platelet-Rich Fibrin/*physiology MH - Prospective Studies MH - Tooth Extraction/methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Wound Healing/*physiology MH - Young Adult EDAT- 2018/04/10 06:00 MHDA- 2019/03/08 06:00 CRDT- 2018/04/10 06:00 PHST- 2018/04/10 06:00 [entrez] PHST- 2018/04/10 06:00 [pubmed] PHST- 2019/03/08 06:00 [medline] AID - 841121 [pii] AID - 10.3290/j.qi.a40113 [doi] PST - ppublish SO - Quintessence Int. 2018;49(5):377-388. doi: 10.3290/j.qi.a40113. PMID- 31489852 OWN - NLM STAT- MEDLINE DCOM- 20191003 LR - 20191007 IS - 1119-3077 (Print) VI - 22 IP - 9 DP - 2019 Sep TI - Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: A randomized clinical trial. PG - 1189-1195 LID - 10.4103/njcp.njcp_27_19 [doi] AB - AIM: The aim of the present study was to determine whether the use of advanced platelet rich fibrin based on the low speed(+) centrifugation concept (A-PRF(+)) might improve the pain management and healing of delayed wound healing among cases of alveolar osteitis following mandibular third molar extraction. MATERIALS AND METHODS: The patients (N = 40) with a complaint of alveolar osteitis following third molar extractions were divided into two groups: Group I (control; saline only); and Group II (use of A-PRF(+)). Pain was evaluated using the visual analogue scale (VAS). Soft tissue healing was assessed by the modified Index of Landry, Turnbull and Howley and bone density was assessed with the i-Dixel 2.1.8.2 software. Inter-group comparisons were analyzed by means of a student t-test and the Mann Whitney U test to identify group samples. Analysis of variance and the Friedman test were applied for repeated measurements. The Wilcoxon test and Bonferroni's test for multiple comparisons were conducted at the time-factor level. Yates Correction was used to compare qualitative data. RESULTS: In regard to pain, A-PRF(+) application demonstrated rapidly and continually reduced pain intensity at each respective time in comparison to the control. Statistically, the healing rates of epithelium and hard tissue were significantly faster in the A-PRF(+) application group (p: 0.000, P < 0.05). CONCLUSIONS: The results show that A-PRF(+) might represent an improved and accelerating therapeutic development for hard and soft tissue healing in management of alveolar osteitis that is also effective in reducing pain. FAU - Yüce, E AU - Yüce E AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Biruni University, Istanbul, Turkey. FAU - Kömerik, N AU - Kömerik N AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Biruni University, Istanbul, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 RN - 0 (Fibrin Tissue Adhesive) SB - IM MH - Adolescent MH - Adult MH - Dry Socket/*therapy MH - Female MH - Fibrin Tissue Adhesive/*administration & dosage MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Management MH - *Platelet-Rich Fibrin MH - Postoperative Complications/*therapy MH - Prospective Studies MH - Tooth Extraction/*adverse effects/methods MH - Visual Analog Scale MH - Wound Healing/*physiology OTO - NOTNLM OT - A-PRF OT - Alveolar osteitis OT - inflammation OT - platelets OT - wound healing COIS- None EDAT- 2019/09/07 06:00 MHDA- 2019/10/08 06:00 CRDT- 2019/09/07 06:00 PHST- 2019/09/07 06:00 [entrez] PHST- 2019/09/07 06:00 [pubmed] PHST- 2019/10/08 06:00 [medline] AID - NigerJClinPract_2019_22_9_1189_266159 [pii] AID - 10.4103/njcp.njcp_27_19 [doi] PST - ppublish SO - Niger J Clin Pract. 2019 Sep;22(9):1189-1195. doi: 10.4103/njcp.njcp_27_19. PMID- 32183831 OWN - NLM STAT- MEDLINE DCOM- 20200907 LR - 20200907 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 20 IP - 1 DP - 2020 Mar 18 TI - Randomized controlled trial on the effectiveness of absorbable collagen sponge after extraction of impacted mandibular third molar: split-mouth design. PG - 77 LID - 10.1186/s12903-020-1063-3 [doi] LID - 77 AB - BACKGROUND: The purpose of this study was to compare the effectiveness of absorbable collagen sponge insertion in tooth extraction sites for socket healing of the impacted mandibular third molar. METHODS: Thirty-six patients with bilateral mandibular impacted third molars based on Pell-Gregory and Winter classification were included in this study. This study was a randomized clinical trial utilizing a split-mouth design with one side assigned as collagen sponge insertion and the other side assigned as the control. Post-operative clinical complications, periodontal integrities, and radiographic outcomes were assessed at 1, 2, and 14-weeks post operatively. RESULTS: Five patients were excluded during the follow-up period due to loss of follow-up. The study was conducted on 31 patients in total. The mean VAS score of collagen sponge insertion side at 1 week post operation was 1.42 ± 1.26, which was significantly lower than the control side (P < 0.05). The mean probing depth of collagen sponge insertion side at 2-week post operation was 5.55 ± 2.28 mm, which was significantly lower than the control side (7.13 ± 1.86; P < 0.05). Other various measurements including radiographic outcomes showed no significant group differences. CONCLUSIONS: Placement of collagen sponge after extraction of mandibular impacted third molar reduced early stage post-operative complications and enhanced initial healing of soft tissues and periodontal defects. TRIAL REGISTRATION: This study was retrospectively registered at the WHO ICTRP platform and Clinical Research Information Service, KCT0003363. Registered 21 Sep 2018. FAU - Kim, Jin-Woo AU - Kim JW AD - Department of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans University, Seoul, South Korea. FAU - Seong, Tae-Whan AU - Seong TW AD - Department of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans University, Seoul, South Korea. FAU - Cho, Sura AU - Cho S AD - Department of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans University, Seoul, South Korea. FAU - Kim, Sun-Jong AU - Kim SJ AD - Department of Oral and Maxillofacial Surgery, School of Medicine, Ewha Womans University, Seoul, South Korea. oralsurgeonsj@gmail.com. LA - eng SI - CRiS/KCT0003363 GR - 2020R1A2C4001842/National Research Foundation of Korea (KR)/International PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20200318 TA - BMC Oral Health JT - BMC oral health JID - 101088684 RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) SB - D SB - IM MH - Adult MH - Biocompatible Materials/*administration & dosage MH - Collagen/*administration & dosage MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - *Surgical Sponges MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Wound Closure Techniques MH - Wound Healing PMC - PMC7079387 OTO - NOTNLM OT - *Collagen sponge OT - *Complication OT - *Periodontal defect OT - *Radiographic OT - *Surgical extraction OT - *Third molar COIS- The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. EDAT- 2020/03/19 06:00 MHDA- 2020/09/08 06:00 CRDT- 2020/03/19 06:00 PHST- 2019/06/14 00:00 [received] PHST- 2020/03/04 00:00 [accepted] PHST- 2020/03/19 06:00 [entrez] PHST- 2020/03/19 06:00 [pubmed] PHST- 2020/09/08 06:00 [medline] AID - 10.1186/s12903-020-1063-3 [pii] AID - 1063 [pii] AID - 10.1186/s12903-020-1063-3 [doi] PST - epublish SO - BMC Oral Health. 2020 Mar 18;20(1):77. doi: 10.1186/s12903-020-1063-3. PMID- 32683390 OWN - NLM STAT- MEDLINE DCOM- 20200901 LR - 20200911 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 25 IP - 5 DP - 2020 Sep 1 TI - Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial. PG - e644-e651 LID - 10.4317/medoral.23661 [doi] AB - BACKGROUND: The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery. MATERIAL AND METHODS: A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% dexpanthenol, 0.15% allantoin and 0.01% sodium saccharin was selected for this split mouth randomized controlled and double-blind trial including 36 patients with bilaterally and symmetrically impacted lower third molars. The teeth (n=72) were randomly divided into two groups before surgical removal: control group (CG; in which a placebo was given) and experimental group (EG). Swelling, trismus, postoperative pain, wound healing and complications were measured and recorded in order to evaluate differences between the placebo and experimental product. RESULTS: Five patients suffered from an alveolitis in the CG (13.9%), and none in the study group (0%), but no statistically significant difference was found (p=0.063). From day 0 to day 7, trismus and swelling were significantly less pronounced in the EG, and wound healing was considered 'good' in 22.2% for the CG and 97.2% for the EG (p<0.001). Mean VAS scores during the seven postoperative days were statistically lower in the study (2.56±1,19) compared to the placebo group (3.25±1.6) (p=0.002). The mean consumption of analgesic pills during the first 92 hours was also statistically lower in the EG (0.26±0.51) in comparison to the CG (0.56±0.67) (p=0.003). CONCLUSIONS: The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation. Future studies should further evaluate, if the gel is effective in dry socket preventing after third molar removal. FAU - Sáez-Alcaide, L-M AU - Sáez-Alcaide LM FAU - Molinero-Mourelle, P AU - Molinero-Mourelle P FAU - González-Serrano, J AU - González-Serrano J FAU - Rubio-Alonso, L AU - Rubio-Alonso L FAU - Bornstein, M-M AU - Bornstein MM FAU - López-Quiles, J AU - López-Quiles J LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200901 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 19F5HK2737 (Pantothenic Acid) RN - 1O6C93RI7Z (dexpanthenol) RN - 344S277G0Z (Allantoin) RN - 9012-76-4 (Chitosan) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Allantoin MH - *Chitosan MH - Chlorhexidine MH - Double-Blind Method MH - Edema MH - Humans MH - Inflammation MH - Molar, Third MH - Pain, Postoperative MH - Pantothenic Acid/analogs & derivatives MH - Prospective Studies MH - Tooth Extraction MH - *Tooth, Impacted MH - Trismus PMC - PMC7473436 COIS- Conflicts of interest The authors claim to have no financial interest, either directly or indirectly, in the products or information listed in the paper. EDAT- 2020/07/20 06:00 MHDA- 2020/09/02 06:00 CRDT- 2020/07/20 06:00 PHST- 2020/01/03 00:00 [received] PHST- 2020/05/19 00:00 [accepted] PHST- 2020/07/20 06:00 [pubmed] PHST- 2020/09/02 06:00 [medline] PHST- 2020/07/20 06:00 [entrez] AID - 23661 [pii] AID - 10.4317/medoral.23661 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2020 Sep 1;25(5):e644-e651. doi: 10.4317/medoral.23661. PMID- 31319609 OWN - NLM STAT- MEDLINE DCOM- 20200305 LR - 20200305 IS - 1660-3397 (Electronic) IS - 1660-3397 (Linking) VI - 17 IP - 7 DP - 2019 Jul 17 TI - Chitosan Use in Dentistry: A Systematic Review of Recent Clinical Studies. LID - 10.3390/md17070417 [doi] LID - 417 AB - This study aims to highlight the latest marine-derived technologies in the biomedical field. The dental field, in particular, uses many marine-derived biomaterials, including chitosan. Chitosan that is used in different fields of medicine, is analyzed in this review with the aim of highlighting its uses and advantages in the dental field. A literature search was conducted in scientific search engines, using keywords in order to achieve the highest possible number of results. A review of randomized controlled trials (RCT) was conducted to evaluate and process all the relevant results for chitosan and oral health. After a screening and a careful analysis of the literature, there were only 12 results highlighted. Chitosan performs different functions and it is used in different fields of dentistry in a safe and effective way. Among the uses of chitosan, we report on the remineralizing property of chitosan which hardens tissues of the tooth, and therefore its role as a desensibilizer used in toothpastes. According to our systematic review, the use of chitosan has shown better surgical healing of post-extraction oral wounds. Furthermore, some studies show a reduction in bacterial biofilm when used in dental cements. In addition, it has antibacterial, antifungal, hemostatic and other systemic properties which aid its use for drug delivering. FAU - Cicciù, Marco AU - Cicciù M AD - Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy. mcicciu@unime.it. FAU - Fiorillo, Luca AU - Fiorillo L AD - Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy. AD - Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", Naples 80100, Italy. FAU - Cervino, Gabriele AU - Cervino G AD - Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20190717 TA - Mar Drugs JT - Marine drugs JID - 101213729 RN - 0 (Biocompatible Materials) RN - 0 (Dental Cements) RN - 0 (Toothpastes) RN - 9012-76-4 (Chitosan) SB - IM MH - Biocompatible Materials/*pharmacology MH - Biofilms/drug effects MH - Chitosan/*pharmacology MH - Dental Cements/pharmacology MH - Dentistry/*methods MH - Drug Delivery Systems/methods MH - Humans MH - Oral Health MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/adverse effects MH - Tooth Remineralization/*methods MH - Toothpastes/pharmacology MH - Treatment Outcome MH - Wound Healing/drug effects PMC - PMC6669505 OTO - NOTNLM OT - chitosan OT - dental material OT - dentistry OT - marine drugs OT - oral surgery COIS- The authors declare no conflict of interest. EDAT- 2019/07/20 06:00 MHDA- 2020/03/07 06:00 CRDT- 2019/07/20 06:00 PHST- 2019/05/06 00:00 [received] PHST- 2019/07/11 00:00 [revised] PHST- 2019/07/16 00:00 [accepted] PHST- 2019/07/20 06:00 [entrez] PHST- 2019/07/20 06:00 [pubmed] PHST- 2020/03/07 06:00 [medline] AID - md17070417 [pii] AID - marinedrugs-17-00417 [pii] AID - 10.3390/md17070417 [doi] PST - epublish SO - Mar Drugs. 2019 Jul 17;17(7):417. doi: 10.3390/md17070417. PMID- 22622663 OWN - NLM STAT- MEDLINE DCOM- 20120830 LR - 20181201 IS - 1544-0591 (Electronic) IS - 0022-0345 (Linking) VI - 91 IP - 7 DP - 2012 Jul TI - Coronectomy vs. total removal for third molar extraction: a systematic review. PG - 659-65 LID - 10.1177/0022034512449346 [doi] AB - The objective of this systematic review was to compare the outcomes between coronectomy and total removal for third molar extractions with high risk of nerve injury and to help practitioners make prudent decisions on whether and how third molars should be removed. PubMed, Embase, Web of Science, CENTRAL, and SIGLE were searched from January 1990 to October 2011 for randomized or non-randomized controlled trials. Four studies met our inclusion criteria. The pooled risk ratio (coronectomy vs. total removal) was 0.11 (95% CI = 0.03-0.36), 1.03 (95% CI = 0.54-1.98), 0.55 (95% CI = 0.28-1.05), and 1.14 (95% CI = 0.57-2.30) for inferior alveolar nerve injury, post-operative infection, dry socket, and pain at 1 wk after surgery, respectively. A relatively high rate of failed coronectomy in one study (38.3%, compared with 2.3%-9.4% in others) may be attributed to a higher proportion of narrowing roots and vertical impactions. Although root migration rate was high (13.2%-85.29%), the migration distances were short (3.06 ± 1.67 mm), and the directions were away from the nerves. Moreover, the rates of re-operation and root exposure were low. Therefore, coronectomy appears superior to total removal for reducing inferior alveolar nerve damage and could be used in clinical practice for third molar extractions with high risk of nerve injury. FAU - Long, H AU - Long H AD - State Key Laboratory of Oral Diseases, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. FAU - Zhou, Y AU - Zhou Y FAU - Liao, L AU - Liao L FAU - Pyakurel, U AU - Pyakurel U FAU - Wang, Y AU - Wang Y FAU - Lai, W AU - Lai W LA - eng PT - Comparative Study PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20120523 PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 SB - D SB - IM CIN - Evid Based Dent. 2013;14(2):57-8. PMID: 23792405 CIN - J Am Dent Assoc. 2013 Oct;144(10):1172-3. PMID: 24080934 MH - Controlled Clinical Trials as Topic MH - Humans MH - Intention to Treat Analysis MH - Mandibular Nerve MH - Molar, Third/*surgery MH - Postoperative Complications MH - Reoperation MH - Risk Assessment MH - Tooth Crown/*surgery MH - Tooth Extraction/*methods MH - Tooth Migration MH - Treatment Outcome MH - Trigeminal Nerve Injuries/*prevention & control EDAT- 2012/05/25 06:00 MHDA- 2012/08/31 06:00 CRDT- 2012/05/25 06:00 PHST- 2012/05/25 06:00 [entrez] PHST- 2012/05/25 06:00 [pubmed] PHST- 2012/08/31 06:00 [medline] AID - 0022034512449346 [pii] AID - 10.1177/0022034512449346 [doi] PST - ppublish SO - J Dent Res. 2012 Jul;91(7):659-65. doi: 10.1177/0022034512449346. Epub 2012 May 23. PMID- 32368796 OWN - NLM STAT- MEDLINE DCOM- 20200904 LR - 20210504 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 5 IP - 5 DP - 2020 May 4 TI - Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. PG - CD003879 LID - 10.1002/14651858.CD003879.pub5 [doi] LID - CD003879 AB - BACKGROUND: Prophylactic removal of asymptomatic disease-free impacted wisdom teeth is the surgical removal of wisdom teeth in the absence of symptoms and with no evidence of local disease. Impacted wisdom teeth may be associated with pathological changes, such as pericoronitis, root resorption, gum and alveolar bone disease (periodontitis), caries and the development of cysts and tumours. When surgical removal is performed in older people, the risk of postoperative complications, pain and discomfort is increased. Other reasons to justify prophylactic removal of asymptomatic disease-free impacted third molars have included preventing late lower incisor crowding, preventing damage to adjacent structures such as the second molar or the inferior alveolar nerve, in preparation for orthognathic surgery, in preparation for radiotherapy or during procedures to treat people with trauma to the affected area. Removal of asymptomatic disease-free wisdom teeth is a common procedure, and researchers must determine whether evidence supports this practice. This review is an update of an review originally published in 2005 and previously updated in 2012 and 2016. OBJECTIVES: To evaluate the effects of removal compared with retention (conservative management) of asymptomatic disease-free impacted wisdom teeth in adolescents and adults. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 10 May 2019), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2019, Issue 4), MEDLINE Ovid (1946 to 10 May 2019), and Embase Ovid (1980 to 10 May 2019). The US National Institutes of Health Trials Registry (ClinicalTrials.gov)and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. No restrictions were placed on the language or date of publication when searching the electronic databases. . SELECTION CRITERIA: We included randomised controlled trials (RCTs), with no restriction on length of follow-up, comparing removal (or absence) with retention (or presence) of asymptomatic disease-free impacted wisdom teeth in adolescents or adults. We also considered quasi-RCTs and prospective cohort studies for inclusion if investigators measured outcomes with follow-up of five years or longer. DATA COLLECTION AND ANALYSIS: Eight review authors screened search results and assessed the eligibility of studies for inclusion according to the review inclusion criteria. Eight review authors independently and in duplicate conducted the risk of bias assessments. When information was unclear, we contacted the study authors for additional information. MAIN RESULTS: This review update includes the same two studies that were identified in our previous version of the review: one RCT with a parallel-group design, which was conducted in a dental hospital setting in the United Kingdom, and one prospective cohort study, which was conducted in the private sector in the USA. Primary outcome No eligible studies in this review reported the effects of removal compared with retention of asymptomatic disease-free impacted wisdom teeth on health-related quality of life Secondary outcomes We found only low- to very low-certainty evidence of the effects of removal compared with retention of asymptomatic disease-free impacted wisdom teeth for a limited number of secondary outcome measures. One prospective cohort study, reporting data from a subgroup of 416 healthy male participants, aged 24 to 84 years, compared the effects of the absence (previous removal or agenesis) against the presence of asymptomatic disease-free impacted wisdom teeth on periodontitis and caries associated with the distal aspect of the adjacent second molar during a follow-up period of three to over 25 years. Very low-certainty evidence suggests that the presence of asymptomatic disease-free impacted wisdom teeth may be associated with increased risk of periodontitis affecting the adjacent second molar in the long term. In the same study, which is at serious risk of bias, there is insufficient evidence to demonstrate a difference in caries risk associated with the presence or absence of impacted wisdom teeth. One RCT with 164 randomised and 77 analysed adolescent participants compared the effect of extraction with retention of asymptomatic disease-free impacted wisdom teeth on dimensional changes in the dental arch after five years. Participants (55% female) had previously undergone orthodontic treatment and had 'crowded' wisdom teeth. No evidence from this study, which was at high risk of bias, was found to suggest that removal of asymptomatic disease-free impacted wisdom teeth has a clinically significant effect on dimensional changes in the dental arch. The included studies did not measure any of our other secondary outcomes: costs, other adverse events associated with retention of asymptomatic disease-free impacted wisdom teeth (pericoronitis, root resorption, cyst formation, tumour formation, inflammation/infection) and adverse effects associated with their removal (alveolar osteitis/postoperative infection, nerve injury, damage to adjacent teeth during surgery, bleeding, osteonecrosis related to medication/radiotherapy, inflammation/infection). AUTHORS' CONCLUSIONS: Insufficient evidence is available to determine whether asymptomatic disease-free impacted wisdom teeth should be removed or retained. Although retention of asymptomatic disease-free impacted wisdom teeth may be associated with increased risk of periodontitis affecting adjacent second molars in the long term, the evidence is very low certainty. Well-designed RCTs investigating long-term and rare effects of retention and removal of asymptomatic disease-free impacted wisdom teeth, in a representative group of individuals, are unlikely to be feasible. In their continuing absence, high quality, long-term prospective cohort studies may provide valuable evidence in the future. Given the current lack of available evidence, patient values should be considered and clinical expertise used to guide shared decision-making with people who have asymptomatic disease-free impacted wisdom teeth. If the decision is made to retain these teeth, clinical assessment at regular intervals to prevent undesirable outcomes is advisable. CI - Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Ghaeminia, Hossein AU - Ghaeminia H AD - Department of Oral and Maxillofacial Surgery, Rijnstate Hospital Arnhem, Arnhem, Netherlands. FAU - Nienhuijs, Marloes El AU - Nienhuijs ME AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Nijmegen, Netherlands. FAU - Toedtling, Verena AU - Toedtling V AD - Department of Oral and Maxillofacial Surgery, Division of Dentistry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. FAU - Perry, John AU - Perry J AD - Hospital Dental Department, Canterbury District Health Board, Christchurch, New Zealand. FAU - Tummers, Marcia AU - Tummers M AD - Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands. FAU - Hoppenreijs, Theo Jm AU - Hoppenreijs TJ AD - Department of Oral and Maxillofacial Surgery, Rijnstate Hospital, Arnhem, Netherlands. FAU - Van der Sanden, Wil Jm AU - Van der Sanden WJ AD - Department of Quality and Safety of Oral Health Care, College of Dental Science, Radboud University Medical Center, Nijmegen, Netherlands. FAU - Mettes, Theodorus G AU - Mettes TG AD - School of Dentistry, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20200504 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2016 Aug 31;(8):CD003879. PMID: 27578151 MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Asymptomatic Diseases MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Watchful Waiting PMC - PMC7199383 COIS- The participating review authors declare that they have no financial conflicts of interest, nor do they have any associations with industry regarding the topic of this review. Hossein Ghaeminia: none known
John Perry: none known
Marloes EL Nienhuijs: none known
Verena Toedtling: none known
Marcia Tummers: none known
Theo J M Hoppenreijs: none known
Wil JM van der Sanden: none known
Theodorus (Dirk) G Mettes: none known EDAT- 2020/05/06 06:00 MHDA- 2020/09/05 06:00 CRDT- 2020/05/06 06:00 PHST- 2020/05/06 06:00 [entrez] PHST- 2020/05/06 06:00 [pubmed] PHST- 2020/09/05 06:00 [medline] AID - CD003879.pub5 [pii] AID - 10.1002/14651858.CD003879.pub5 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID- 32712962 OWN - NLM STAT- MEDLINE DCOM- 20200918 LR - 20200918 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 7 IP - 7 DP - 2020 Jul 26 TI - Surgical techniques for the removal of mandibular wisdom teeth. PG - CD004345 LID - 10.1002/14651858.CD004345.pub3 [doi] LID - CD004345 AB - BACKGROUND: Pathology relating to mandibular wisdom teeth is a frequent presentation to oral and maxillofacial surgeons, and surgical removal of mandibular wisdom teeth is a common operation. The indications for surgical removal of these teeth are alleviation of local pain, swelling and trismus, and also the prevention of spread of infection that may occasionally threaten life. Surgery is commonly associated with short-term postoperative pain, swelling and trismus. Less frequently, infection, dry socket (alveolar osteitis) and trigeminal nerve injuries may occur. This review focuses on the optimal methods in order to improve patient experience and minimise postoperative morbidity. OBJECTIVES: To compare the relative benefits and risks of different techniques for surgical removal of mandibular wisdom teeth. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health Trials Register (to 8 July 2019), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library; 2019, Issue 6), MEDLINE Ovid (1946 to 8 July 2019), and Embase Ovid (1980 to 8 July 2019). We searched ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform for ongoing trials. We placed no restrictions on the language or date of publication. SELECTION CRITERIA: Randomised controlled trials comparing different surgical techniques for the removal of mandibular wisdom teeth. DATA COLLECTION AND ANALYSIS: Three review authors were involved in assessing the relevance of identified studies, evaluated the risk of bias in included studies and extracted data. We used risk ratios (RRs) for dichotomous data in parallel-group trials (or Peto odds ratios if the event rate was low), odds ratios (ORs) for dichotomous data in cross-over or split-mouth studies, and mean differences (MDs) for continuous data. We took into account the pairing of the split-mouth studies in our analyses, and combined parallel-group and split-mouth studies using the generic inverse-variance method. We used the fixed-effect model for three studies or fewer, and random-effects model for more than three studies. MAIN RESULTS: We included 62 trials with 4643 participants. Several of the trials excluded individuals who were not in excellent health. We assessed 33 of the studies (53%) as being at high risk of bias and 29 as unclear. We report results for our primary outcomes below. Comparisons of different suturing techniques and of drain versus no drain did not report any of our primary outcomes. No studies provided useable data for any of our primary outcomes in relation to coronectomy. There is insufficient evidence to determine whether envelope or triangular flap designs led to more alveolar osteitis (OR 0.33, 95% confidence interval (CI) 0.09 to 1.23; 5 studies; low-certainty evidence), wound infection (OR 0.29, 95% CI 0.04 to 2.06; 2 studies; low-certainty evidence), or permanent altered tongue sensation (Peto OR 4.48, 95% CI 0.07 to 286.49; 1 study; very low-certainty evidence). In terms of other adverse effects, two studies reported wound dehiscence at up to 30 days after surgery, but found no difference in risk between interventions. There is insufficient evidence to determine whether the use of a lingual retractor affected the risk of permanent altered sensation compared to not using one (Peto OR 0.14, 95% CI 0.00 to 6.82; 1 study; very low-certainty evidence). None of our other primary outcomes were reported by studies included in this comparison. There is insufficient evidence to determine whether lingual split with chisel is better than a surgical hand-piece for bone removal in terms of wound infection (OR 1.00, 95% CI 0.31 to 3.21; 1 study; very low-certainty evidence). Alveolar osteitis, permanent altered sensation, and other adverse effects were not reported. There is insufficient evidence to determine whether there is any difference in alveolar osteitis according to irrigation method (mechanical versus manual: RR 0.33, 95% CI 0.01 to 8.09; 1 study) or irrigation volume (high versus low; RR 0.52, 95% CI 0.27 to 1.02; 1 study), or whether there is any difference in postoperative infection according to irrigation method (mechanical versus manual: RR 0.50, 95% CI 0.05 to 5.43; 1 study) or irrigation volume (low versus high; RR 0.17, 95% CI 0.02 to 1.37; 1 study) (all very low-certainty evidence). These studies did not report permanent altered sensation and adverse effects. There is insufficient evidence to determine whether primary or secondary wound closure led to more alveolar osteitis (RR 0.99, 95% CI 0.41 to 2.40; 3 studies; low-certainty evidence), wound infection (RR 4.77, 95% CI 0.24 to 96.34; 1 study; very low-certainty evidence), or adverse effects (bleeding) (RR 0.41, 95% CI 0.11 to 1.47; 1 study; very low-certainty evidence). These studies did not report permanent sensation changes. Placing platelet rich plasma (PRP) or platelet rich fibrin (PRF) in sockets may reduce the incidence of alveolar osteitis (OR 0.39, 95% CI 0.22 to 0.67; 2 studies), but the evidence is of low certainty. Our other primary outcomes were not reported. AUTHORS' CONCLUSIONS: In this 2020 update, we added 27 new studies to the original 35 in the 2014 review. Unfortunately, even with the addition of these studies, we have been unable to draw many meaningful conclusions. The small number of trials evaluating each comparison and reporting our primary outcomes, along with methodological biases in the included trials, means that the body of evidence for each of the nine comparisons evaluated is of low or very low certainty. Participant populations in the trials may not be representative of the general population, or even the population undergoing third molar surgery. Many trials excluded individuals who were not in good health, and several excluded those with active infection or who had deep impactions of their third molars. Consequently, we are unable to make firm recommendations to surgeons to inform their techniques for removal of mandibular third molars. The evidence is uncertain, though we note that there is some limited evidence that placing PRP or PRF in sockets may reduce the incidence of dry socket. The evidence provided in this review may be used as a guide for surgeons when selecting and refining their surgical techniques. Ongoing studies may allow us to provide more definitive conclusions in the future. CI - Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Bailey, Edmund AU - Bailey E AD - Department of Oral Surgery, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Kashbour, Wafa AU - Kashbour W AD - Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. FAU - Shah, Neha AU - Shah N AD - Department of Oral Surgery, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Worthington, Helen V AU - Worthington HV AD - Cochrane Oral Health, Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. FAU - Renton, Tara F AU - Renton TF AD - Department of Oral Surgery, Dental Institute, King's College London, London, UK. FAU - Coulthard, Paul AU - Coulthard P AD - Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. LA - eng SI - ClinicalTrials.gov/NCT02831374 SI - ClinicalTrials.gov/NCT02942108 PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20200726 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2014 Jul 29;(7):CD004345. PMID: 25069437 MH - Adult MH - Bias MH - Drainage/methods MH - Dry Socket/etiology MH - Humans MH - Lip MH - Mandible MH - Middle Aged MH - Molar, Third/*surgery MH - Postoperative Complications/etiology MH - Randomized Controlled Trials as Topic MH - Sensation Disorders/etiology MH - Surgical Flaps MH - Surgical Wound Infection/etiology MH - Therapeutic Irrigation/methods MH - Tongue MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/*surgery MH - Wound Closure Techniques MH - Young Adult PMC - PMC7389870 COIS- Edmund Bailey: none known
Wafa Kashbour: none known
Neha Shah: none known
Helen V Worthington: none known.
Tara F Renton: I am an author of a study included in this review; however, I was not involved in 'Risk of bias' assessment of this study.
Paul Coulthard: none known EDAT- 2020/07/28 06:00 MHDA- 2020/09/20 06:00 PMCR- 2021/07/26 CRDT- 2020/07/27 06:00 PHST- 2021/07/26 00:00 [pmc-release] PHST- 2020/07/27 06:00 [entrez] PHST- 2020/07/28 06:00 [pubmed] PHST- 2020/09/20 06:00 [medline] AID - CD004345.pub3 [pii] AID - 10.1002/14651858.CD004345.pub3 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2020 Jul 26;7(7):CD004345. doi: 10.1002/14651858.CD004345.pub3. PMID- 28586638 OWN - NLM STAT- MEDLINE DCOM- 20171012 LR - 20201209 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 75 IP - 10 DP - 2017 Oct TI - Efficacy of Codeine When Added to Paracetamol (Acetaminophen) and Ibuprofen for Relief of Postoperative Pain After Surgical Removal of Impacted Third Molars: A Double-Blinded Randomized Control Trial. PG - 2063-2069 LID - S0278-2391(17)30504-9 [pii] LID - 10.1016/j.joms.2017.04.045 [doi] AB - PURPOSE: The use of opioids in combination with nonopioids is common practice for acute pain management after third molar surgery. One such combination is paracetamol, ibuprofen, and codeine. The authors assessed the efficacy of codeine when added to a regimen of paracetamol and ibuprofen for pain relief after third molar surgery. MATERIALS AND METHODS: This study was a randomized, double-blinded, placebo-controlled trial conducted in patients undergoing the surgical removal of at least 1 impacted mandibular third molar requiring bone removal. Participants were randomly allocated to a control group (paracetamol 1,000 mg and ibuprofen 400 mg) or an intervention group (paracetamol 1,000 mg, ibuprofen 400 mg, and codeine 60 mg). All participants were treated under intravenous sedation and using identical surgical conditions and technique. Postoperative pain was assessed using the visual analog scale (VAS) every 3 hours (while awake) for the first 48 hours after surgery. Pain was globally assessed using a questionnaire on day 3 after surgery. RESULTS: There were 131 participants (36% men; control group, n = 67; intervention group, n = 64). Baseline characteristics were similar for the 2 groups. Data were analyzed using a modified intention-to-treat analysis and, for this, a linear mixed model was used. The model showed that the baseline VAS score was associated with subsequent VAS scores and that, with each 3-hour period, the VAS score increased by an average of 0.08. The treatment effect was not statistically meaningful, indicating there was no difference in recorded pain levels between the 2 groups during the first 48 hours after mandibular third molar surgery. Similarly, the 2 groups did not differ in their global ratings of postoperative pain. CONCLUSION: Codeine 60 mg added to a regimen of paracetamol 1,000 mg and ibuprofen 400 mg does not improve analgesia after third molar surgery. CI - Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Best, Adrian D AU - Best AD AD - Former Oral and Maxillofacial Surgery Registrar, University of Otago, Dunedin, New Zealand. Electronic address: adrianucx@gmail.com. FAU - De Silva, R K AU - De Silva RK AD - Associate Professor, Oral and Maxillofacial Surgeon, University of Otago, Dunedin, New Zealand. FAU - Thomson, W M AU - Thomson WM AD - Professor, Dental Epidemiologist, University of Otago, Dunedin, New Zealand. FAU - Tong, Darryl C AU - Tong DC AD - Professor, Oral and Maxillofacial Surgeon, University of Otago, Dunedin, New Zealand. FAU - Cameron, Claire M AU - Cameron CM AD - Biostatistician, University of Otago, Dunedin, New Zealand. FAU - De Silva, Harsha L AU - De Silva HL AD - Oral and Maxillofacial Surgeon, University of Otago, Dunedin, New Zealand. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170515 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - D SB - IM MH - Acetaminophen/*administration & dosage MH - Analgesics, Non-Narcotic/*administration & dosage MH - Analgesics, Opioid/*administration & dosage MH - Codeine/*administration & dosage MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Ibuprofen/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain Management/*methods MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2017/06/07 06:00 MHDA- 2017/10/13 06:00 CRDT- 2017/06/07 06:00 PHST- 2016/12/01 00:00 [received] PHST- 2017/03/19 00:00 [revised] PHST- 2017/04/27 00:00 [accepted] PHST- 2017/06/07 06:00 [pubmed] PHST- 2017/10/13 06:00 [medline] PHST- 2017/06/07 06:00 [entrez] AID - S0278-2391(17)30504-9 [pii] AID - 10.1016/j.joms.2017.04.045 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2017 Oct;75(10):2063-2069. doi: 10.1016/j.joms.2017.04.045. Epub 2017 May 15. PMID- 32800608 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20201222 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 58 IP - 9 DP - 2020 Nov TI - A systematic review of the complications of high-risk third molar removal and coronectomy: development of a decision tree model and preliminary health economic analysis to assist in treatment planning. PG - e16-e24 LID - S0266-4356(20)30337-5 [pii] LID - 10.1016/j.bjoms.2020.07.015 [doi] AB - Coronectomy is an alternative surgical technique for the management of high-risk third molars. It involves the removal of the crown of a tooth and the deliberate retention of the roots, thereby avoiding injury to the inferior alveolar nerve (IAN). Previous studies have suggested that it reduces the risk of nerve injury when compared with surgical extraction. The purpose of this study was to systematically review the incidence of complications following coronectomy such as IAN injury, pain, dry socket, infection, root migration, and need for re-operation. A comparative cost analysis of coronectomy and surgical extraction was done based on the results of the review. This provides an insight into the economic implications of the two procedures. A search through the MEDLINE database via Ovid, PubMed, Scopus, EMBASE via Ovid, and Web of Science, was carried out to extract randomised and non-randomised controlled trials. Four studies fulfilled the inclusion criteria. A meta-analysis was conducted to measure the overall effect of each outcome. The pooled odds ratio (OR) for IAN injury was 0.16 (95% CI 0.01 to 0.39). Coronectomy reduced this risk by 84%. Dry socket may occur less frequently following coronectomy whereas infection did not show a higher incidence with either intervention. Root migration was found to occur in 13%-85% of cases and the average incidence of re-operation was 2.2%. The ratio of the average costs was 1.12 favouring coronectomy if cone-beam computed tomography (CBCT) was not done prior to the procedure. If a scan was taken routinely for coronectomy, the cost ratio marginally favoured extraction. Coronectomy reduced the risk of nerve injury in high-risk third molars. Definitive conclusions, however, cannot be made for outcomes such as the need for re-operation, which may alter the cost ratio of coronectomy:extraction, as higher quality studies with longer follow-up are needed. CI - Copyright © 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Pitros, P AU - Pitros P AD - Department of Oral Surgery, Edinburgh Dental Institute, University of Edinburgh, Lauriston Place, Lauriston Building, Edinburgh EH3 9HA, UK. Electronic address: panagiotis.pitros@icloud.com. FAU - O'Connor, N AU - O'Connor N AD - Department of Oral Surgery, Edinburgh Dental Institute, University of Edinburgh, Lauriston Place, Lauriston Building, Edinburgh EH3 9HA, UK. Electronic address: normaocob@gmail.com. FAU - Tryfonos, A AU - Tryfonos A AD - Research Institute of Sports and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK. Electronic address: A.Tryfonos@2016.ljmu.ac.uk. FAU - Lopes, V AU - Lopes V AD - Department of Oral Surgery, Edinburgh Dental Institute, University of Edinburgh, Lauriston Place, Lauriston Building, Edinburgh EH3 9HA, UK. Electronic address: victorlopes64@icloud.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20200814 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Decision Trees MH - Humans MH - Mandible MH - Mandibular Nerve MH - Molar, Third/surgery MH - *Tooth Crown/surgery MH - Tooth Extraction/adverse effects MH - *Tooth, Impacted/surgery MH - *Trigeminal Nerve Injuries OTO - NOTNLM OT - *Coronectomy OT - *Cost-benefit analysis OT - *Inferior alveolar nerve injury OT - *Surgical extraction OT - *Systematic review EDAT- 2020/08/18 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/08/18 06:00 PHST- 2019/08/02 00:00 [received] PHST- 2020/07/13 00:00 [accepted] PHST- 2020/08/18 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/08/18 06:00 [entrez] AID - S0266-4356(20)30337-5 [pii] AID - 10.1016/j.bjoms.2020.07.015 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2020 Nov;58(9):e16-e24. doi: 10.1016/j.bjoms.2020.07.015. Epub 2020 Aug 14. PMID- 27475700 OWN - NLM STAT- MEDLINE DCOM- 20180416 LR - 20190609 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 21 IP - 6 DP - 2016 Nov 1 TI - The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction. PG - e696-e702 AB - BACKGROUND: Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar. MATERIAL AND METHODS: A split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel. RESULTS: The groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound's aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups. CONCLUSIONS: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients' postoperative comfort; however, improved wound healing was observed. FAU - Madrazo-Jiménez, M AU - Madrazo-Jiménez M AD - Facultad de Odontología de Sevilla, C/ Avicena s/n 41009, Sevilla, Spain, danieltl@us.es. FAU - Rodríguez-Caballero, Á AU - Rodríguez-Caballero Á FAU - Serrera-Figallo, M-Á AU - Serrera-Figallo MÁ FAU - Garrido-Serrano, R AU - Garrido-Serrano R FAU - Gutiérrez-Corrales, A AU - Gutiérrez-Corrales A FAU - Gutiérrez-Pérez, J-L AU - Gutiérrez-Pérez JL FAU - Torres-Lagares, D AU - Torres-Lagares D LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20161101 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Anti-Infective Agents, Local) RN - 344S277G0Z (Allantoin) RN - 9012-76-4 (Chitosan) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Allantoin/*therapeutic use MH - Anti-Infective Agents, Local/*therapeutic use MH - Chitosan MH - Chlorhexidine/*therapeutic use MH - Humans MH - Mandible MH - Molar, Third MH - Pain, Postoperative MH - Spain MH - *Tooth Extraction MH - *Tooth, Impacted MH - Wound Healing PMC - PMC5116111 COIS- The authors have declared that no conflict of interest exist. EDAT- 2016/11/05 06:00 MHDA- 2018/04/17 06:00 CRDT- 2016/08/01 06:00 PHST- 2016/02/29 00:00 [received] PHST- 2016/03/29 00:00 [accepted] PHST- 2016/11/05 06:00 [pubmed] PHST- 2018/04/17 06:00 [medline] PHST- 2016/08/01 06:00 [entrez] AID - 21281 [pii] AID - 10.4317/medoral.21281 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2016 Nov 1;21(6):e696-e702. doi: 10.4317/medoral.21281. PMID- 29223633 OWN - NLM STAT- MEDLINE DCOM- 20190325 LR - 20190325 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 56 IP - 1 DP - 2018 Jan TI - Effectiveness of irrigation with chlorhexidine after removal of mandibular third molars: a randomised controlled trial. PG - 54-59 LID - S0266-4356(17)30738-6 [pii] LID - 10.1016/j.bjoms.2017.11.010 [doi] AB - To evaluate the effect of postoperative irrigation with chlorhexidine on inflammatory complications after the extraction of lower third molars under local anaesthesia, we recruited 100 patients to participate in a controlled, single-blind, randomised clinical trial. They were assigned to one of two groups: the intervention group (postoperative irrigation of the surgical site with chlorhexidine for seven days) or the control group (postoperative chlorhexidine mouth rinse for seven days). The primary outcome variables were pain, swelling, trismus, infection, and alveolar osteitis. The secondary outcome variables were wound dehiscence and food impaction. A total of 95 participants completed the study (47 in the irrigation group and 48 in the rinse group). In the irrigation group, alveolar osteitis and facial swelling had reduced significantly at seven days postoperatively (both p<0.01). Pain scores had also reduced significantly at seven days (p<0.01), but not at 48hours, and patients had lower levels of food impaction (p<0.01) and less severe symptoms (p=0.02). Routine irrigation with chlorhexidine after the extraction of third molars helps to reduce pain and lowers the incidence of alveolar osteitis. CI - Copyright © 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Cho, H AU - Cho H AD - School of Medicine, The University of Queensland, Brisbane, Australia. Electronic address: h.cho@uq.edu.au. FAU - David, M C AU - David MC AD - School of Public Health, The University of Queensland, Brisbane, Australia. FAU - Lynham, A J AU - Lynham AJ AD - School of Medicine, The University of Queensland, Brisbane, Australia. FAU - Hsu, E AU - Hsu E AD - Maxillofacial Unit, Royal Brisbane and Women's Hospital, Brisbane, Australia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20171206 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 2018 Jul;56(6):563. PMID: 29773239 MH - Adolescent MH - Adult MH - Aged MH - Chlorhexidine/*therapeutic use MH - Dry Socket/drug therapy/etiology MH - Female MH - Humans MH - Incidence MH - Male MH - Mandible/*surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Pain/drug therapy/etiology MH - Postoperative Complications/drug therapy/etiology MH - Single-Blind Method MH - Surgery, Oral/methods MH - Surgical Wound Dehiscence/drug therapy/etiology MH - Therapeutic Irrigation/*methods MH - *Tooth Extraction MH - Treatment Outcome MH - Trismus/drug therapy/etiology MH - Young Adult OTO - NOTNLM OT - *chlorhexidine OT - *complications OT - *irrigation OT - *oral surgery OT - *postoperative OT - *third molar(s) OT - *wisdom teeth EDAT- 2017/12/11 06:00 MHDA- 2019/03/26 06:00 CRDT- 2017/12/11 06:00 PHST- 2017/02/28 00:00 [received] PHST- 2017/11/21 00:00 [accepted] PHST- 2017/12/11 06:00 [pubmed] PHST- 2019/03/26 06:00 [medline] PHST- 2017/12/11 06:00 [entrez] AID - S0266-4356(17)30738-6 [pii] AID - 10.1016/j.bjoms.2017.11.010 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2018 Jan;56(1):54-59. doi: 10.1016/j.bjoms.2017.11.010. Epub 2017 Dec 6. PMID- 15620767 OWN - NLM STAT- MEDLINE DCOM- 20050301 LR - 20111117 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 43 IP - 1 DP - 2005 Feb TI - A randomised controlled clinical trial to compare the incidence of injury to the inferior alveolar nerve as a result of coronectomy and removal of mandibular third molars. PG - 7-12 AB - We randomised 128 patients who required operations on mandibular third molars and who had radiological evidence of proximity of the third molar to the canal of the inferior alveolar nerve to one of two operations: extraction [n=102], and coronectomy [n=94]. Some roots were dislodged during intended coronectomy and were therefore removed, resulting in two subgroups (successful coronectomy n=58, and failed coronectomy n=36). The mean (S.D.) follow up was 25 (13) months. Nineteen nerves were damaged (19%) after extraction, none after successful coronectomy, and three (8%) after failed coronectomy (p=0.01). The incidence of dry socket infection was similar in the three groups (10/102, 10%, 7/58, 12%, and 4/36, 11%, respectively). No root required removal or reoperation. To our knowledge this is the first clinical trial of the efficacy of coronectomy in preserving the inferior alveolar nerve. The length of follow up was about 2 years, which for the assessment of delayed eruption of the root fragments is not sufficient as this process may continue for up to 10 years. However, it seems that coronectomy reduces the incidence of injury to the inferior alveolar nerve without increasing the risk of dry socket or infection. FAU - Renton, T AU - Renton T AD - Department of Oral and Maxillofacial Surgery, Dental Institute, Bart's and the London Hospital, Queen Mary's School of Medicine and Dentistry, Ground Floor, Turner Street, London E1 2AD, UK. T.F.renton@qmul.ac.uk FAU - Hankins, M AU - Hankins M FAU - Sproate, C AU - Sproate C FAU - McGurk, M AU - McGurk M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 2006 Feb;44(1):75; author reply 76. PMID: 15936124 CIN - Br J Oral Maxillofac Surg. 2006 Feb;44(1):75-6; author reply 76-7. PMID: 15998557 MH - Adult MH - Cranial Nerve Injuries/etiology/prevention & control MH - Dry Socket/etiology MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Tooth Crown/*surgery MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - *Trigeminal Nerve Injuries EDAT- 2004/12/29 09:00 MHDA- 2005/03/02 09:00 CRDT- 2004/12/29 09:00 PHST- 2004/09/08 00:00 [accepted] PHST- 2004/12/29 09:00 [pubmed] PHST- 2005/03/02 09:00 [medline] PHST- 2004/12/29 09:00 [entrez] AID - S0266-4356(04)00186-X [pii] AID - 10.1016/j.bjoms.2004.09.002 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2005 Feb;43(1):7-12. doi: 10.1016/j.bjoms.2004.09.002. PMID- 30810357 OWN - NLM STAT- MEDLINE DCOM- 20190701 LR - 20200701 IS - 0250-832X (Print) IS - 1476-542X (Electronic) IS - 0250-832X (Linking) VI - 48 IP - 5 DP - 2019 Jul TI - Cone beam CT imaging of the mandibular third molar: a position paper prepared by the European Academy of DentoMaxilloFacial Radiology (EADMFR). PG - 20190039 LID - 10.1259/dmfr.20190039 [doi] LID - 20190039 AB - OBJECTIVES: Lack of evidence on the use of CBCT for management of mandibular third molars in Radiation Protection guideline no. 172 of the European Commission made the European Academy of DentoMaxilloFacial Radiology (EADMFR) decide to update the recommendations of the guideline. METHODS AND MATERIALS: A literature search was performed addressing the following questions: (1) does CBCT change the treatment of the patient?; (2) does CBCT reduce the number of post-operative sensory disturbances of the inferior alveolar nerve?; and (3) can CBCT predict the risk for a post-operative sensory disturbance of the inferior alveolar nerve? RESULTS: : Since the European Commission published the guideline in 2012 several high-evidence studies on the use of CBCT before removal of mandibular third molars have been conducted including five randomized controlled clinical trials and one meta-analysis. Present literature allows to propose recommendations with highest level of evidence. CONCLUSION: New and up-to-date evidence-based recommendations advocate that CBCT imaging of the mandibular third molar should not be applied as a routine method before removal of mandibular third molars and therefore, CBCT imaging should only be applied when the surgeon has a very specific clinical question in an individual patient case that cannot be answered by conventional (panoramic and/or intraoral) imaging. FAU - Matzen, Louise Hauge AU - Matzen LH AD - 1 Department of Dentistry and Oral Health, Section of Oral Radiology, Aarhus University , Aarhus , Denmark. FAU - Berkhout, Erwin AU - Berkhout E AD - 2 Department of Oral Radiology and Radiation Protection, Academic Center for Dentistry, VU University & University of Amsterdam , The Netherlands. LA - eng PT - Journal Article PT - Review DEP - 20190305 TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - D MH - *Cone-Beam Computed Tomography MH - Humans MH - Mandible MH - Mandibular Nerve/diagnostic imaging MH - Meta-Analysis as Topic MH - *Molar, Third/diagnostic imaging MH - *Radiography, Panoramic MH - Randomized Controlled Trials as Topic PMC - PMC6747425 OTO - NOTNLM OT - CBCT, surgery OT - molar, third EDAT- 2019/02/28 06:00 MHDA- 2019/07/02 06:00 CRDT- 2019/02/28 06:00 PHST- 2019/02/28 06:00 [pubmed] PHST- 2019/07/02 06:00 [medline] PHST- 2019/02/28 06:00 [entrez] AID - 10.1259/dmfr.20190039 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 2019 Jul;48(5):20190039. doi: 10.1259/dmfr.20190039. Epub 2019 Mar 5. PMID- 32020130 OWN - NLM STAT- MEDLINE DCOM- 20200206 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 51 IP - 3 DP - 2020 TI - Treatment of periodontal pockets at the distal aspect of mandibular second molar after surgical removal of impacted third molar and application of L-PRF: a split-mouth randomized clinical trial. PG - 204-211 LID - 10.3290/j.qi.a43947 [doi] AB - OBJECTIVES: Presence of clinical attachment loss on the distal aspect to the second molar may be associated with malposition of the third molar. The aim of this study was to evaluate the reduction of clinical attachment loss at the distal aspect of the second molar after third molar extraction and application of leukocyte- and platelet-rich fibrin (L-PRF). METHOD AND MATERIALS: Eighteen subjects with a clinical attachment loss on the distal site to the second molar associated with impacted third molar in both sides of the jaw were recruited for the study. For each subject the teeth were randomly allocated in test and control groups. After surgical removal of the impacted third molar, the L-PRF was inserted in the fresh alveolar socket of test sites; in the control sites no graft was inserted after extraction. Full-mouth plaque score, full-mouth bleeding score, clinical attachment level (CAL), probing depth, and gingival recession were assessed at baseline and 6 months later. RESULTS: After 6 months, mean CAL change was 1.99 ± 1.18 mm in the test group and 1.15 ± 1.01 mm in the control group; probing depth change was 1.33 ± 0.87 mm in the test group and 0.50 ± 0.63 mm in the control group. Statistically significant differences (P < .05) were observed between groups in terms of CAL and probing depth changes. No differences were found in gingival recession changes. CONCLUSION: Within the limits of the present study, the sites treated by means of application of L-PRF after impacted third molar extraction showed better results in terms of CAL gain and probing depth reduction when compared with control sites. FAU - Gasparro, Roberta AU - Gasparro R FAU - Sammartino, Gilberto AU - Sammartino G FAU - Mariniello, Mauro AU - Mariniello M FAU - di Lauro, Alessandro Espedito AU - di Lauro AE FAU - Spagnuolo, Gianrico AU - Spagnuolo G FAU - Marenzi, Gaetano AU - Marenzi G LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Humans MH - Molar MH - Molar, Third MH - Periodontal Pocket MH - *Platelet-Rich Fibrin MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - clinical attachment level OT - periodontal defects OT - platelet-rich fibrin OT - third molar EDAT- 2020/02/06 06:00 MHDA- 2020/02/07 06:00 CRDT- 2020/02/06 06:00 PHST- 2020/02/06 06:00 [entrez] PHST- 2020/02/06 06:00 [pubmed] PHST- 2020/02/07 06:00 [medline] AID - 841288 [pii] AID - 10.3290/j.qi.a43947 [doi] PST - ppublish SO - Quintessence Int. 2020;51(3):204-211. doi: 10.3290/j.qi.a43947. PMID- 33058774 OWN - NLM STAT- MEDLINE DCOM- 20210209 LR - 20210209 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 79 IP - 2 DP - 2021 Feb TI - Third Molar Surgery Outcomes: A Randomized Clinical Trial Comparing Submucosal and Intravenous Dexamethasone. PG - 295-304 LID - S0278-2391(20)31138-1 [pii] LID - 10.1016/j.joms.2020.09.020 [doi] AB - OBJECTIVE: Swelling, pain, and trismus after third molar surgery have a negative impact on patients' quality-of-life in the days following surgery. The study aims to compare the efficacy of submucosal (SM) dexamethasone and intravenous (IV) dexamethasone in reducing these outcomes. METHODS: The single-center study was designed as a randomized, controlled, double-blinded trial with a total of 130 participants evenly allocated into 2 treatment groups. All participants underwent the surgical removal of at least 2 mandibular third molars under intravenous sedation. The outcome variables studied were swelling, pain, and maximum incisal distances. The swelling was measured using a 3-dimensional camera (3dMD Inc, Atlanta, GA). The pain was quantified using a 100 mm visual analog scale (VAS). Maximum incisal distances were measured using a caliper. Participants completed the short-form Oral Health Impact Profile (OHIP-14). The 2 groups were compared using cross-tabulations and chi-square tests for categorical variables and analysis of variance for continuous variables. RESULTS: The participants had a mean age of 22.6 years, 56.8% females and 12.4% smokers. There were no statistically significant differences in the distribution of study variables between the 2 groups. On day 2, mean facial swelling measurements were 7.3 cm(3) in the IV group and 7.8 cm(3) in the SM group (P > .05). The mean pain score was 31 in the IV group and 33 in the SM group (P > .05). The mean maximum incisal distances were 33.7 mm in the IV group and 34.5 mm in the SM group (P > .05). Both groups experienced poorer quality-of-life relative to baseline scores and were affected to a similar extent. CONCLUSIONS: There are no differences in swelling, pain, and trismus between submucosal and intravenous dexamethasone in third molar surgery. Submucosal dexamethasone is a straightforward and accessible route of steroid administration in patients having third molar surgery under local anesthesia only. CI - Copyright © 2020 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Lau, Adelyn Ai Lyn AU - Lau AAL AD - Specialist Oral Surgeon - Private Practitioner, Faculty of Dentistry, University of Otago, Department of Oral Diagnostics and Surgical Sciences, Dunedin, New Zealand. Electronic address: Dr.adelynlau@gmail.com. FAU - De Silva, Rohana Kumara AU - De Silva RK AD - Associate Professor, Consultant Oral and Maxillofacial Surgeon, Faculty of Dentistry, University of Otago, Department of Oral Diagnostics and Surgical Sciences, Dunedin, New Zealand. FAU - Thomson, Murray AU - Thomson M AD - Professor of Dental Epidemiology and Public Health, Faculty of Dentistry, University of Otago, Department of Oral Sciences, Dunedin, New Zealand. FAU - De Silva, Harsha AU - De Silva H AD - Senior Lecturer, Consultant Oral and Maxillofacial Surgeon, Faculty of Dentistry, University of Otago, Department of Oral Diagnostics and Surgical Sciences, Dunedin, New Zealand. FAU - Tong, Darryl AU - Tong D AD - Professor, Consultant Oral and Maxillofacial Surgeon, Head of Department of Oral Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Otago, Department of Oral Diagnostics and Surgical Sciences, Dunedin, New Zealand. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200917 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 7S5I7G3JQL (Dexamethasone) SB - AIM SB - D SB - IM MH - Adult MH - Dexamethasone/therapeutic use MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Injections MH - Male MH - *Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - Prospective Studies MH - Tooth Extraction MH - *Tooth, Impacted/surgery MH - Trismus MH - Young Adult EDAT- 2020/10/16 06:00 MHDA- 2021/02/10 06:00 CRDT- 2020/10/15 20:09 PHST- 2020/07/25 00:00 [received] PHST- 2020/09/09 00:00 [revised] PHST- 2020/09/14 00:00 [accepted] PHST- 2020/10/16 06:00 [pubmed] PHST- 2021/02/10 06:00 [medline] PHST- 2020/10/15 20:09 [entrez] AID - S0278-2391(20)31138-1 [pii] AID - 10.1016/j.joms.2020.09.020 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2021 Feb;79(2):295-304. doi: 10.1016/j.joms.2020.09.020. Epub 2020 Sep 17. PMID- 31654643 OWN - NLM STAT- MEDLINE DCOM- 20200917 LR - 20200917 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 2 DP - 2020 Feb TI - Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A Randomized Controlled Trial. PG - 215.e1-215.e8 LID - S0278-2391(19)31145-0 [pii] LID - 10.1016/j.joms.2019.09.019 [doi] AB - PURPOSE: Complications during local anesthesia include increased blood pressure and vasovagal reflex, which are caused by changes in the autonomic nervous system. The commonly used local anesthetic preparations are lidocaine to which the vasoconstrictor epinephrine is added (lidocaine-epinephrine) and prilocaine to which the vasoconstrictor felypressin is added (prilocaine-felypressin); however, their effects during dental treatment are unclear. We examined the effects of these 2 different local anesthetic preparations on the autonomic nervous system and circulation during extraction of the impacted mandibular third molar. MATERIALS AND METHODS: In this randomized controlled trial, 40 female patients scheduled for extraction of an impacted mandibular third molar were randomized to the lidocaine-epinephrine group or prilocaine-felypressin group. Heart rate variability, heart rate, and systolic blood pressure were recorded during the experiment. Descriptive and bivariate statistics were computed, and the P value was set at .05. RESULTS: The low frequency-high frequency ratio was significantly increased in the prilocaine-felypressin group during extraction compared with that in the lidocaine-epinephrine group (P < .05). In the lidocaine-epinephrine group, a significant decrease in the high-frequency component was observed during bone removal and extraction compared with that at rest (P < .05). In both groups, a significant increase in systolic blood pressure was observed during local anesthesia, incision and reflection of the flap, bone removal, separation of the tooth crown, extraction, and suturing compared with that at rest (P < .01). CONCLUSIONS: This study is the first to investigate the differences in the influence of 2 different local anesthetic preparations on the autonomic nervous system during extraction of the mandibular third molar. Changes in circulatory dynamics during tooth extraction with the 2 different local anesthetic preparations were the result of a decrease in parasympathetic nervous activity with lidocaine-epinephrine and an increase in sympathetic nervous activity with prilocaine-felypressin. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Yamashita, Kaoru AU - Yamashita K AD - Assistant Professor, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Kibe, Toshiro AU - Kibe T AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Surgery, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Electronic address: s2000@dent.kagoshima-u.ac.jp. FAU - Shidou, Rumi AU - Shidou R AD - PhD Student, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Kohjitani, Atsushi AU - Kohjitani A AD - Associate Professor, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Nakamura, Norifumi AU - Nakamura N AD - Professor, Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Surgery, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Sugimura, Mitsutaka AU - Sugimura M AD - Professor, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190925 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - 046O35D44R (Prilocaine) RN - 56-59-7 (Felypressin) RN - 98PI200987 (Lidocaine) RN - YKH834O4BH (Epinephrine) SB - AIM SB - D SB - IM MH - *Anesthesia, Dental MH - Anesthetics, Local MH - Autonomic Nervous System MH - Epinephrine MH - *Felypressin MH - Female MH - Humans MH - Lidocaine MH - Molar, Third MH - Prilocaine MH - Vasoconstrictor Agents EDAT- 2019/10/28 06:00 MHDA- 2020/09/18 06:00 CRDT- 2019/10/27 06:00 PHST- 2019/08/05 00:00 [received] PHST- 2019/09/13 00:00 [accepted] PHST- 2019/10/28 06:00 [pubmed] PHST- 2020/09/18 06:00 [medline] PHST- 2019/10/27 06:00 [entrez] AID - S0278-2391(19)31145-0 [pii] AID - 10.1016/j.joms.2019.09.019 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Feb;78(2):215.e1-215.e8. doi: 10.1016/j.joms.2019.09.019. Epub 2019 Sep 25. PMID- 26554107 OWN - NLM STAT- MEDLINE DCOM- 20151209 LR - 20190918 IS - 0042-8450 (Print) IS - 0042-8450 (Linking) VI - 72 IP - 9 DP - 2015 Sep TI - A clinical study on the influence of suturing material on oral wound healing. PG - 765-9 AB - BACKGROUND/AIM: Suture materials play an important role in healing, enabling reconstruction and reassembly of tissue separated by the surgical procedure or trauma, and at the same time facilitating and promoting healing and hemostasis. Suture materials are used daily in oral surgery, and are considered to be substances most commonly implanted in human body. The aim of this clinical study was to examine the speed of wound healing and complications incidence, after the use of three different absorbable synthetic suture materials in oral surgery (catgut, Dexon and Vicryl rapide), and to ascertain which one is the most suitable for oral surgery. METHODS: The study was conducted on 96 patients undergoing root resection or surgical extraction of third molars. Each of the suture materials (catgut, Dexon and Vicryl rapide) was used for 8 root resections and 8 surgical third molar extractions in the maxilla, as well as in the mandible (a total of 32 surgical interventions for each suture material). RESULTS: The faster wound healing was obtained with Vicryl rapide compared to other two suturing material tested. There was no significant difference regarding the presence of local reaction in all the three groups of patients on the 21st postoperative day. CONCLUSION: The results of our clinical study point out that Vycril- rapid contributes more than catgut or Dexon to faster healing of human wounds, with fewer incidences of wound dehiscence and milder local reactions. FAU - Gazivoda, Dragan AU - Gazivoda D FAU - Pelemiš, Dejan AU - Pelemiš D FAU - Vujašković, Goran AU - Vujašković G LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Serbia TA - Vojnosanit Pregl JT - Vojnosanitetski pregled JID - 21530700R RN - 26009-03-0 (Polyglycolic Acid) RN - 34346-01-5 (Polyglactin 910) SB - IM MH - Adult MH - Catgut/*adverse effects MH - Female MH - Humans MH - Male MH - Polyglactin 910/*pharmacology MH - Polyglycolic Acid/*pharmacology MH - *Surgical Wound Dehiscence/etiology/prevention & control MH - *Suture Techniques/adverse effects/instrumentation MH - Tooth Diseases/*surgery MH - *Tooth Extraction/adverse effects/instrumentation/methods MH - Tooth Root/*surgery MH - Treatment Outcome MH - Wound Healing EDAT- 2015/11/12 06:00 MHDA- 2015/12/15 06:00 CRDT- 2015/11/12 06:00 PHST- 2015/11/12 06:00 [entrez] PHST- 2015/11/12 06:00 [pubmed] PHST- 2015/12/15 06:00 [medline] AID - 10.2298/vsp140401064g [doi] PST - ppublish SO - Vojnosanit Pregl. 2015 Sep;72(9):765-9. doi: 10.2298/vsp140401064g. PMID- 32024498 OWN - NLM STAT- MEDLINE DCOM- 20200810 LR - 20200810 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 20 IP - 1 DP - 2020 Feb 5 TI - Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial. PG - 41 LID - 10.1186/s12903-020-1029-5 [doi] LID - 41 AB - BACKGROUND: This study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted. METHODS: Patients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect. RESULTS: It was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29). CONCLUSIONS: It was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar. TRIAL REGISTRATION: This clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018. FAU - Glória, José Cristiano Ramos AU - Glória JCR AD - Departament of Dentistry, Faculty of Biologic Sciences and Health, Federal University of Jequitinhonha and Mucuri Valleys, Rua da Glória, 187, Centro, Diamantina, Minas Gerais, Brazil. FAU - Douglas-de-Oliveira, Dhelfeson Willya AU - Douglas-de-Oliveira DW AUID- ORCID: 0000-0002-8628-3122 AD - Departament of Dentistry, Faculty of Biologic Sciences and Health, Federal University of Jequitinhonha and Mucuri Valleys, Rua da Glória, 187, Centro, Diamantina, Minas Gerais, Brazil. dhelfeson@hotmail.com. FAU - E Silva, Larissa Doalla Almeida AU - E Silva LDA AD - Departament of Dentistry, Faculty of Biologic Sciences and Health, Federal University of Jequitinhonha and Mucuri Valleys, Rua da Glória, 187, Centro, Diamantina, Minas Gerais, Brazil. FAU - Falci, Saulo Gabriel Moreira AU - Falci SGM AUID- ORCID: 0000-0001-9438-5199 AD - Departament of Dentistry, Faculty of Biologic Sciences and Health, Federal University of Jequitinhonha and Mucuri Valleys, Rua da Glória, 187, Centro, Diamantina, Minas Gerais, Brazil. FAU - Dos Santos, Cássio Roberto Rocha AU - Dos Santos CRR AD - Departament of Dentistry, Faculty of Biologic Sciences and Health, Federal University of Jequitinhonha and Mucuri Valleys, Rua da Glória, 187, Centro, Diamantina, Minas Gerais, Brazil. LA - eng SI - ClinicalTrials.gov/NCT03501225 PT - Journal Article PT - Randomized Controlled Trial DEP - 20200205 TA - BMC Oral Health JT - BMC oral health JID - 101088684 RN - 059QF0KO0R (Water) RN - 66H7ZZK23N (Ozone) SB - D SB - IM CIN - J Am Dent Assoc. 2020 Sep;151(9):e75. PMID: 32620232 MH - Double-Blind Method MH - Edema/etiology/*therapy MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Ozone/*therapeutic use MH - Pain, Postoperative/etiology/*therapy MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/etiology/*therapy MH - Water/*pharmacology PMC - PMC7003333 OTO - NOTNLM OT - *Oral surgery OT - *Ozone OT - *Pain OT - *Swelling OT - *Third molar OT - *Trismus COIS- The authors declare that they have no competing interests. EDAT- 2020/02/07 06:00 MHDA- 2020/08/11 06:00 CRDT- 2020/02/07 06:00 PHST- 2019/09/04 00:00 [received] PHST- 2020/01/29 00:00 [accepted] PHST- 2020/02/07 06:00 [entrez] PHST- 2020/02/07 06:00 [pubmed] PHST- 2020/08/11 06:00 [medline] AID - 10.1186/s12903-020-1029-5 [pii] AID - 1029 [pii] AID - 10.1186/s12903-020-1029-5 [doi] PST - epublish SO - BMC Oral Health. 2020 Feb 5;20(1):41. doi: 10.1186/s12903-020-1029-5. PMID- 27055228 OWN - NLM STAT- MEDLINE DCOM- 20170420 LR - 20170817 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 74 IP - 7 DP - 2016 Jul TI - Is Low-Level Laser Therapy Effective in the Management of Pain and Swelling After Mandibular Third Molar Surgery? PG - 1322.e1-8 LID - S0278-2391(16)00266-4 [pii] LID - 10.1016/j.joms.2016.02.030 [doi] AB - PURPOSE: This study evaluated the effect of low-level laser therapy (LLLT) on decreasing pain and swelling after removal of impacted third molars. PATIENTS AND METHODS: This randomized, double-blinded, split-mouth study included patients presenting 2 symmetrically impacted mandibular third molars. In each participant, one side was randomly assigned to laser treatment and the other side received placebo. LLLT was performed by intraoral application of a 660-nm laser (200 mW, 6 J per point at 4 points) followed by extraoral application of an 810-nm laser (200 mW, 6 J per point at 3 points). Irradiation at the 810-nm wavelength was repeated on days 2 and 4 after surgery. On the control side, the treatment protocol was similar to the experimental side, but with laser simulation. The main outcomes were the degree of pain during the next 7 days and the edema coefficients on days 2, 4, and 7 after surgery. Data were analyzed using generalized linear models to determine the effect of group and time on pain level and edema coefficients. RESULTS: The final sample consisted of 40 patients. Pain level was significantly lower in the laser than in the placebo side at all time points during the experiment (P < .05). Swelling was significantly lower in the laser than in the placebo group on days 2, 4, and 7 after surgery (P < .05). CONCLUSION: LLLT proved effective in decreasing the intensity of pain and swelling after removal of impacted third molars and can be recommended to alleviate patients' symptoms after surgery. CI - Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Eshghpour, Majid AU - Eshghpour M AD - Associate Professor of Oral and Maxillofacial Surgery, Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Ahrari, Farzaneh AU - Ahrari F AD - Assistant Professor of Orthodontics, Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Farzaneh.Ahrari@Gmail.com. FAU - Takallu, Mohammad AU - Takallu M AD - Private Practice, Mashhad University of Medical Sciences, Mashhad, Iran. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160312 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Double-Blind Method MH - Edema/radiotherapy MH - Female MH - Humans MH - Lasers, Semiconductor/*therapeutic use MH - Low-Level Light Therapy/methods MH - Male MH - Molar, Third/*surgery MH - Pain Management MH - Pain Measurement MH - Pain, Postoperative/*radiotherapy MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult EDAT- 2016/04/08 06:00 MHDA- 2017/04/21 06:00 CRDT- 2016/04/08 06:00 PHST- 2015/09/22 00:00 [received] PHST- 2016/01/30 00:00 [revised] PHST- 2016/02/27 00:00 [accepted] PHST- 2016/04/08 06:00 [entrez] PHST- 2016/04/08 06:00 [pubmed] PHST- 2017/04/21 06:00 [medline] AID - S0278-2391(16)00266-4 [pii] AID - 10.1016/j.joms.2016.02.030 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2016 Jul;74(7):1322.e1-8. doi: 10.1016/j.joms.2016.02.030. Epub 2016 Mar 12. PMID- 30287719 OWN - NLM STAT- MEDLINE DCOM- 20190930 LR - 20190930 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 19 IP - 9 DP - 2018 Sep 1 TI - The Efficiency of Three Irrigating Solutions after Surgical Removal of Impacted Mandibular Third Molars: A Cross-sectional Study. PG - 1147-1151 AB - AIM: The present study was conducted to assess the effect of irrigation with three different irrigants, namely normal saline, chlorhexidine, and povidone iodine on pain, alveolar osteitis, swelling, trismus, infection, and food impaction during surgical removal of impacted mandibular third molar. MATERIALS AND METHODS: Forty-eight patients, including 26 males and 22 females, fulfilling criteria for inclusion in this study were divided into three groups: group I where irrigant used was normal saline, group II as chlorhexidine, and group III as povidone iodine group. RESULTS: The pain was significantly more in groups I and III in 24 hours and 7th day as well. Alveolar osteitis was noted in groups III and I, nil in group II. The facial swelling measured in millimeters on 24 hours and on 7th day was significantly higher in 24 hours in groups I and III than in group II. Trismus was significantly more in group I and group III than in group II (with p < 0.01) on 7th day. CONCLUSION: It is concluded that chlorhexidine is effective in reducing pain, alveolar osteitis, swelling, and trismus when used as an irrigant following surgical removal of impacted third molar. CLINICAL SIGNIFICANCE: Chlorhexidine as irrigating solution helps in reducing the postoperative consequences after third molar surgery. Further studies are required using large sample size. FAU - Jadhao, Varsha A AU - Jadhao VA AD - Department of Dentistry, Government Medical College, Akola Maharashtra, India. FAU - Rao, Amit AU - Rao A AD - Department of Oral and Maxillofacial Surgery, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College & Hospital, Hingoli Maharashtra, India. FAU - Hande, Pratik AU - Hande P AD - Department of Oral and Maxillofacial Surgery, Dr. D. Y Patil Dental School, Pune, Maharashtra, India. FAU - Mahajani, Monica AU - Mahajani M AD - Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College & Hospital, Hingoli, Maharashtra, India. FAU - Raktade, Prashant P AU - Raktade PP AD - Department of Oral and Maxillofacial Surgery, Government Dental College & Hospital, Aurangabad, Maharashtra, India. FAU - Gedam, Ravidra AU - Gedam R AD - Department of Oral Pathology, Dr. Rajesh Ramdasji Kambe Dental College & Hospital, Akola, Maharashtra, India. FAU - Acharya, Vishwas AU - Acharya V AD - Department of Oral Medicine and Diagnosis, Dr. Hedgewar Smruti Rugna Seva Mandal Dental College & Hospital, Hingoli Maharashtra, India. FAU - Tekale, Pawankumar D AU - Tekale PD AD - Department of Orthodontics, Dr. Rajesh Ramdasji Kambe Dental College & Hospital, Akola, Maharashtra, India, Phone: +918087100345 e-mail: pawan0804@gmail.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180901 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 RN - 0 (Saline Solution) RN - 0 (Solutions) RN - 85H0HZU99M (Povidone-Iodine) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adult MH - Chlorhexidine/*administration & dosage MH - Cross-Sectional Studies MH - Dry Socket/therapy MH - Edema/therapy MH - Female MH - Humans MH - *Intraoperative Care MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/therapy MH - Postoperative Complications/therapy MH - Povidone-Iodine/*administration & dosage MH - Saline Solution/*administration & dosage MH - Solutions MH - Therapeutic Irrigation/*methods MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/therapy MH - Young Adult OTO - NOTNLM OT - Chlorhexidine OT - Mandibular third molar OT - Normal saline Povidone iodine. EDAT- 2018/10/06 06:00 MHDA- 2019/10/01 06:00 CRDT- 2018/10/06 06:00 PHST- 2018/10/06 06:00 [entrez] PHST- 2018/10/06 06:00 [pubmed] PHST- 2019/10/01 06:00 [medline] AID - 1526-3711-2164 [pii] PST - epublish SO - J Contemp Dent Pract. 2018 Sep 1;19(9):1147-1151. PMID- 31540844 OWN - NLM STAT- MEDLINE DCOM- 20200303 LR - 20200303 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 57 IP - 10 DP - 2019 Dec TI - Efficacy of secondary closure technique after extraction of third molars: a meta-analysis. PG - 977-984 LID - S0266-4356(19)30347-X [pii] LID - 10.1016/j.bjoms.2019.08.028 [doi] AB - The purpose of this study was to assess the influence of two suture methods on the postoperative complications of extraction of mandibular third molars (M3M). We searched the MEDLINE (PubMed), Cochrane Library, and Web of Science databases until 18 May 2018 for randomised controlled trials (RCT) that evaluated the influence of any suture techniques on postoperative complications after the removal of impacted M3M. Pain, facial swelling, and trismus were measured for both the early stage (2-3 days) and late stage (5-7 days) after extraction. We identified 655 records, of which five were assessed for eligibility. All trials included had a moderate risk of bias. The analysis showed that the patients whose wounds had been closed primarily had significantly more pain than those whose wounds were closed secondarily (a wedge of mucosa) during the early stage (standardised mean difference (SMD), -0.49; 95% CI -0.71 to -0.27; P<0.0001) and the late stage (SMD -0.36; 95% CI -0.54 to -0.19; P<0.0001) after the removal of impacted M3M. Patients whose wounds were closed secondarily had less swelling (mm) at the postoperative early stage (SMD -1.12; 95% CI -1.57 to -0.66; P<0.00001) and late stage (SMD -0.51; 95% CI -0.68 to -0.33; P<0.00001). There was more trismus in the primary closure group than in the secondary group during both stages. Our findings suggest that secondary closure causes less pain, facial swelling, and trismus in both early and late stages of surgical removal of impacted M3M, and therefore it improves the quality of life by reducing postoperative discomfort. CI - Copyright © 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Ma, Shixing AU - Ma S AD - Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration. FAU - Li, Xiaole AU - Li X AD - Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration. FAU - Zhang, Aobo AU - Zhang A AD - Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration. FAU - Liu, Shaopeng AU - Liu S AD - Ningbo Stomatology Hospital. Number 287, Jie Fang Nan Lu, Ningbo 315010, Zhejiang Province, China. FAU - Zhao, Haoming AU - Zhao H AD - Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration. FAU - Zhao, Huaqiang AU - Zhao H AD - Department of Oral and Maxillofacial Surgery, College of Stomatology, Shandong University, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China. Electronic address: zhaohq@sdu.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20190917 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Edema MH - Humans MH - *Molar, Third MH - Pain, Postoperative MH - Postoperative Complications MH - Quality of Life MH - *Tooth Extraction MH - *Tooth, Impacted MH - Trismus OTO - NOTNLM OT - *impacted teeth OT - *primary closure OT - *secondary closure OT - *third molar EDAT- 2019/09/22 06:00 MHDA- 2020/03/04 06:00 CRDT- 2019/09/22 06:00 PHST- 2019/02/20 00:00 [received] PHST- 2019/08/29 00:00 [accepted] PHST- 2019/09/22 06:00 [pubmed] PHST- 2020/03/04 06:00 [medline] PHST- 2019/09/22 06:00 [entrez] AID - S0266-4356(19)30347-X [pii] AID - 10.1016/j.bjoms.2019.08.028 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2019 Dec;57(10):977-984. doi: 10.1016/j.bjoms.2019.08.028. Epub 2019 Sep 17. PMID- 29374327 OWN - NLM STAT- MEDLINE DCOM- 20181221 LR - 20181221 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 22 IP - 6 DP - 2018 Jul TI - Tranexamic acid as a local hemostasis method after dental extraction in patients on warfarin: a randomized controlled clinical study. PG - 2281-2289 LID - 10.1007/s00784-017-2327-4 [doi] AB - OBJECTIVES: The present work is a controlled, blinded, and randomized clinical trial comparing hemostatic measures for the control of post-tooth extraction hemorrhage in patients on anticoagulation therapy with warfarin. MATERIALS AND METHODS: The sample consisted of 37 patients (37.8% male and 62.2% female) with a mean age of 45.5 years. After randomization, 20 patients were allocated to the control group (conventional hemostasis measures) and 17 to the study group (addition of local tranexamic acid). All variables that could influence the outcome were similar between the groups and no significant difference was seen (p > 0.05). RESULTS: In the assessment of immediate hemostasis, for the control group, the time to achieve cessation of bleeding was 9.1 (± 3.6) minutes. For the study group this was much lower, and this difference (6.018 / confidence interval of 95%, 4.677 to 7.359) was statistically significant (p < 0.001). In evaluating the control of intermediate hemorrhage, the use of tranexamic acid was more significantly associated with the absence of bleeding, especially in the first 24 h. CONCLUSIONS AND CLINICAL RELEVANCE: Thus, this measure of local hemostasis in topical form with gauze compression and irrigation was shown to be more effective in reducing the time to attain immediate hemostasis, and in preventing intermediate hemorrhage. FAU - Queiroz, Salomão Israel Monteiro Lourenço AU - Queiroz SIML AD - Departamento de Odontologia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. salomaoisrael10@gmail.com. FAU - Silvestre, Valeria Damasceno AU - Silvestre VD AD - Departamento de Odontologia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. FAU - Soares, Renata Monteiro AU - Soares RM AD - Hemocentro Dalton Cunha (Hemonorte), Natal, Brazil. FAU - Campos, Giordano Bruno Paiva AU - Campos GBP AD - Departamento de Odontologia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. FAU - Germano, Adriano Rocha AU - Germano AR AD - Departamento de Odontologia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. FAU - da Silva, José Sandro Pereira AU - da Silva JSP AD - Departamento de Odontologia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. jspsilva@gmail.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180126 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Anticoagulants) RN - 0 (Antifibrinolytic Agents) RN - 0 (Hemostatics) RN - 5Q7ZVV76EI (Warfarin) RN - 6T84R30KC1 (Tranexamic Acid) SB - D MH - Anticoagulants/*administration & dosage MH - Antifibrinolytic Agents/*therapeutic use MH - Female MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/*prevention & control MH - Postoperative Complications/*prevention & control MH - *Tooth Extraction MH - Tranexamic Acid/*therapeutic use MH - Treatment Outcome MH - Warfarin/*administration & dosage OTO - NOTNLM OT - Oral hemorrhage OT - Surgery, oral OT - Tranexamic acid OT - Warfarin EDAT- 2018/01/28 06:00 MHDA- 2018/12/24 06:00 CRDT- 2018/01/28 06:00 PHST- 2016/06/13 00:00 [received] PHST- 2017/12/21 00:00 [accepted] PHST- 2018/01/28 06:00 [pubmed] PHST- 2018/12/24 06:00 [medline] PHST- 2018/01/28 06:00 [entrez] AID - 10.1007/s00784-017-2327-4 [pii] AID - 10.1007/s00784-017-2327-4 [doi] PST - ppublish SO - Clin Oral Investig. 2018 Jul;22(6):2281-2289. doi: 10.1007/s00784-017-2327-4. Epub 2018 Jan 26. PMID- 30900152 OWN - NLM STAT- MEDLINE DCOM- 20191029 LR - 20200225 IS - 1996-9805 (Electronic) IS - 1818-6300 (Linking) VI - 20 IP - 4 DP - 2019 Aug TI - Effectiveness of topical haemocoagulase as a haemostatic agent in children undergoing extraction of primary teeth: a split-mouth, randomised, double-blind, clinical trial. PG - 311-317 LID - 10.1007/s40368-018-0406-0 [doi] AB - AIM: To assess the effectiveness of topically-administered haemocoagulase (batroxobin) (HC) following dental extractions in children. DESIGN: Split-mouth design, where either HC (test) or Normal Saline (control) (NS) was administered to children (5-9 years) requiring bilateral extractions of primary molars. Participants were randomised to (i) extraction sequence; (ii) test-solution administered thereafter. OUTCOME MEASURE: time taken (in seconds) for complete cessation of bleeding. RESULTS: Thirty participants completed the trial receiving HS (n = 30) and NS (n = 30). No adverse events were reported. Time to bleeding cessation was lower in HS group (82.5 ± 13.99 s) than NS group (240.5 ± 54.34 s). Difference between groups (paired t test) was statistically very highly significant (P = 0.000). CONCLUSION: Topical HC produced significant reductions in time for haemostasis and was clinically effective in controlling haemorrhage from extraction wounds in children. HC may be favourably utilised by paediatric dentists, especially with pre-cooperative or special-healthcare-needs patients, improving patient care. FAU - Swamy, D F AU - Swamy DF AUID- ORCID: 0000-0001-6426-0168 AD - Department of Paedodontics and Preventive Dentistry, Goa Dental College and Hospital, Bambolim, Goa, 403202, India. dfswamy@gmail.com. FAU - Barretto, E S AU - Barretto ES AD - Department of Paedodontics and Preventive Dentistry, Goa Dental College and Hospital, Bambolim, Goa, 403202, India. FAU - Rodrigues, J S L AU - Rodrigues JSL AD - Department of Paedodontics and Preventive Dentistry, Goa Dental College and Hospital, Bambolim, Goa, 403202, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190321 PL - England TA - Eur Arch Paediatr Dent JT - European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry JID - 101277157 RN - 0 (Hemostatics) RN - EC 3.4.21.- (Batroxobin) SB - D SB - IM MH - *Batroxobin MH - Child MH - Double-Blind Method MH - *Hemostatics MH - Humans MH - Mouth MH - Tooth Extraction MH - Tooth, Deciduous OTO - NOTNLM OT - Batroxobin OT - Blood coagulation*/drug effects OT - Clinical trial OT - Haemocoagulase OT - Haemostatics OT - Human OT - Oral haemorrhage/prevention and control OT - Primary teeth OT - Tooth extraction OT - Tooth socket/drug effects OT - Treatment outcome OT - Whole blood coagulation time EDAT- 2019/03/23 06:00 MHDA- 2019/10/30 06:00 CRDT- 2019/03/23 06:00 PHST- 2018/10/10 00:00 [received] PHST- 2018/12/07 00:00 [accepted] PHST- 2019/03/23 06:00 [pubmed] PHST- 2019/10/30 06:00 [medline] PHST- 2019/03/23 06:00 [entrez] AID - 10.1007/s40368-018-0406-0 [pii] AID - 10.1007/s40368-018-0406-0 [doi] PST - ppublish SO - Eur Arch Paediatr Dent. 2019 Aug;20(4):311-317. doi: 10.1007/s40368-018-0406-0. Epub 2019 Mar 21. PMID- 32776170 OWN - NLM STAT- MEDLINE DCOM- 20200922 LR - 20200922 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 24 IP - 10 DP - 2020 Oct TI - Is the extraction of third molars a risk factor for the temporomandibular disorders? A systematic review. PG - 3325-3334 LID - 10.1007/s00784-020-03277-6 [doi] AB - BACKGROUND: The aim of this study was to evaluate through a systematic review the extraction of third molars as a risk factor for temporomandibular disorders (TMDs). TYPES OF STUDIES REVIEWED: Randomized and nonrandomized controlled clinical trials where patients underwent third molar extraction and with qualitative evaluation of TMDs before and after extraction were included. RESULTS: After applying the inclusion criteria, seven nonrandomized clinical studies were included. QUIPS tool showed that four articles presented a moderate and three a high risk of bias (RoB). Six studies reported that TMDs presented higher level after removal of third molars ranging from OR, 1.81 to 2.15/RR, 2.1. However, one study showed no significant association. GRADE showed heterogeneity in relation to general results, which means that confidence in the estimated effects varied from low to moderate GRADE. The quality of clinical recommendations decreased especially due to the risk of bias in some of the included studies evaluated with the QUIPS tool. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Third molar extraction can be associated with the development of TMD signs and symptoms. Furthermore, TMD can be aggravated according to the third molar location, the degree of impaction and surgical difficulty, age, and gender. This systematic review highlights the need to perform randomized clinical trials with diagnostic criteria and standardized surgical procedures. FAU - Damasceno, Yohana Sandy Souza AU - Damasceno YSS AD - Department of Orthodontics, Dental School, Faculty of Dentistry, Federal University of Pará (UFPA), Augusto Correa St., no 1, Belém, Pará, 66075-110, Brazil. FAU - Espinosa, Daybelis González AU - Espinosa DG AD - Department of Orthodontics, Dental School, Faculty of Dentistry, Federal University of Pará (UFPA), Augusto Correa St., no 1, Belém, Pará, 66075-110, Brazil. AD - Facultad de Odontologi, Universidad Católica Redemptoris Mater, Managua, Nicaragua. FAU - Normando, David AU - Normando D AD - Department of Orthodontics, Dental School, Faculty of Dentistry, Federal University of Pará (UFPA), Augusto Correa St., no 1, Belém, Pará, 66075-110, Brazil. davidnormando@hotmail.com. LA - eng PT - Journal Article PT - Review DEP - 20200810 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - D MH - Humans MH - Molar, Third MH - Risk Factors MH - *Temporomandibular Joint Disorders MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - Oral surgery OT - Risk OT - Temporomandibular joint OT - Temporomandibular joint disorders OT - Temporomandibular joint dysfunction syndrome OT - Third molar EDAT- 2020/08/11 06:00 MHDA- 2020/09/23 06:00 CRDT- 2020/08/11 06:00 PHST- 2020/03/12 00:00 [received] PHST- 2020/04/04 00:00 [accepted] PHST- 2020/08/11 06:00 [pubmed] PHST- 2020/09/23 06:00 [medline] PHST- 2020/08/11 06:00 [entrez] AID - 10.1007/s00784-020-03277-6 [pii] AID - 10.1007/s00784-020-03277-6 [doi] PST - ppublish SO - Clin Oral Investig. 2020 Oct;24(10):3325-3334. doi: 10.1007/s00784-020-03277-6. Epub 2020 Aug 10. PMID- 32071470 OWN - NLM STAT- MEDLINE DCOM- 20200221 LR - 20200917 IS - 1671-167X (Print) IS - 1671-167X (Linking) VI - 52 IP - 1 DP - 2020 Feb 18 TI - [Application of β-TCP for bone defect restore after the mandibular third molars extraction: A splitmouth clinical trial]. PG - 97-102 AB - OBJECTIVE: To evaluate the effect of bone defect regeneration and the periodontal status of the second molars after mandibular third molars extraction using β-tertiary calcium phosphate (β-TCP) in the test side compared with the spontaneously healed side. To the bone defect of mandibular second molars as a result of surgical removal of impacted mandibular third molars is a common phenomenon, many research shows that the mandibular second molars alveolar bone regeneration was about 1.5 mm and the periodontal pocket >7 mm was greater than 43.3% after mandibular third molars extraction. There has been significant progress researches in the repair of bone defect after the third molar removal, and bone graft filling was one of the effective methods. The bone graft substitutes include autogenous bone, allograft bone, xenograft bone and synthetic bone. METHODS: A split mouth, randomized clinical study was designed. Fifteen patients with mandibular third molars in the same jaw planned to be extracted were enrolled in the study. One of the sockets of each patient was randomly selected and filled with easy-graftTMCLASSIC (test group). The contralateral socket was left to heal spontaneously (control group). cone beam computed tomography (CBCT) scans were performed the day after the extraction and after 6 months. The horizontal dimensional changes of the sockets were recorded. The newly formed bone volume in the bone was analyzed by CBCT, and the probing depth (PD) was recorded. Student's t test was used to evaluate the difference between the two groups for each parameter, and the P value lower than 0.05 was considered to be statistically significant. RESULTS: Fifteen patients (30 sockets) completed the flow-up, and all the 30 sockets healed uneventfully. After 6 months' healing, the new bone volume fraction of the test group was 63.3%±2.2%, while the new bone volume fraction of the control group was 50.1%±1.9%. The vertical dimensional increment of the test group was (5.53±0.39) mm, while the vertical change of the control group was (1.53±0.27) mm. The distal buccal site PD of the second molar was (3.0±0.7) mm in the test group, and (6.5±0.8) mm in the control group. Statistically significant differences were detected between the two groups. CONCLUSION: The randomized controlled clinical trial showed that the application of β-TCP for bone defect repair after the mandibular third molars extraction resulted in more vertical bone regeneration and less probing depth when compared with what was spontaneously healed. FAU - Cao, C AU - Cao C AD - Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. FAU - Wang, F AU - Wang F AD - Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. FAU - Wang, E B AU - Wang EB AD - Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. FAU - Liu, Y AU - Liu Y AD - Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. LA - chi PT - Journal Article PT - Randomized Controlled Trial TA - Beijing Da Xue Xue Bao Yi Xue Ban JT - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences JID - 101125284 RN - 0 (Calcium Phosphates) RN - K4C08XP666 (tricalcium phosphate) SB - IM MH - Calcium Phosphates MH - Humans MH - Mandible MH - Molar MH - *Molar, Third MH - Tooth Extraction MH - *Tooth, Impacted PMC - PMC7439054 OAB - Publisher: Abstract available from the publisher. OABL- chi EDAT- 2020/02/20 06:00 MHDA- 2020/02/23 06:00 CRDT- 2020/02/20 06:00 PHST- 2020/02/20 06:00 [entrez] PHST- 2020/02/20 06:00 [pubmed] PHST- 2020/02/23 06:00 [medline] AID - bjdxxbyxb-52-1-97 [pii] AID - 10.19723/j.issn.1671-167X.2020.01.015 [doi] PST - ppublish SO - Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Feb 18;52(1):97-102. doi: 10.19723/j.issn.1671-167X.2020.01.015. PMID- 30902602 OWN - NLM STAT- MEDLINE DCOM- 20200807 LR - 20200807 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 77 IP - 6 DP - 2019 Jun TI - The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. PG - 1153.e1-1153.e8 LID - S0278-2391(19)30240-X [pii] LID - 10.1016/j.joms.2019.02.028 [doi] AB - PURPOSE: Pain, anxiety, and nervousness related to dental procedures can cause acute changes in the autonomic nervous system. Music is widely accepted as a relaxation method during dental treatment; however, its effects during dental treatment are unclear. The authors explored the effects of listening to music during extraction of the impacted mandibular third molar on the autonomic nervous system and the psychological state and hypothesized that listening to music would suppress sympathetic nervous activity and decrease anxiety. MATERIALS AND METHODS: In this prospective study, 40 patients scheduled for extraction of an impacted mandibular third molar were randomized into 2 groups: extraction without music (control group) and extraction while listening to music (music group). Heart rate variability was recorded during the experiment, and Modified Dental Anxiety Scale and State-Trait Anxiety Inventory (STAI) scores were recorded before and after the procedure. Descriptive and bivariate statistics were computed and the P value was set at .05. RESULTS: An increased low-to-high frequency ratio was observed in the control group during incision and flap reflection, bone removal, and separation of the tooth crown; the ratio was significantly decreased in the music group during these time points (P < .05). Compared with the control group, the music group had a significantly greater decrease in postoperative STAI State Anxiety scores from preoperative levels (P < .05). CONCLUSIONS: This study suggested that listening to music while undergoing extraction of the impacted mandibular third molar suppresses activity of the sympathetic nerves during incision, flap reflection, bone removal, and separation of the tooth crown and relieves anxiety after treatment. Future studies will focus on the mechanisms involved and methods to prevent the onset of systemic incidents. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Yamashita, Kaoru AU - Yamashita K AD - PhD Student, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Kibe, Toshiro AU - Kibe T AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Surgery, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Electronic address: s2000@dent.kagoshima-u.ac.jp. FAU - Ohno, Sachi AU - Ohno S AD - Assistant Professor, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Kohjitani, Atsushi AU - Kohjitani A AD - Associate Professor, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. FAU - Sugimura, Mitsutaka AU - Sugimura M AD - Professor, Department of Dental Anesthesiology, Field of Oral Maxillofacial Rehabilitation, Developmental Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190225 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Anxiety MH - Autonomic Nervous System MH - *Dental Anxiety/therapy MH - Humans MH - Molar, Third MH - *Music MH - *Pain Management MH - Prospective Studies MH - Tooth Extraction MH - *Tooth, Impacted EDAT- 2019/03/25 06:00 MHDA- 2020/08/08 06:00 CRDT- 2019/03/24 06:00 PHST- 2018/12/17 00:00 [received] PHST- 2019/01/21 00:00 [revised] PHST- 2019/02/14 00:00 [accepted] PHST- 2019/03/25 06:00 [pubmed] PHST- 2020/08/08 06:00 [medline] PHST- 2019/03/24 06:00 [entrez] AID - S0278-2391(19)30240-X [pii] AID - 10.1016/j.joms.2019.02.028 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2019 Jun;77(6):1153.e1-1153.e8. doi: 10.1016/j.joms.2019.02.028. Epub 2019 Feb 25. PMID- 18486782 OWN - NLM STAT- MEDLINE DCOM- 20080616 LR - 20080519 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 66 IP - 6 DP - 2008 Jun TI - Hemostasis of oral surgery wounds with the HemCon Dental Dressing. PG - 1177-83 LID - 10.1016/j.joms.2007.12.023 [doi] AB - PURPOSE: This study evaluated the efficacy of the HemCon Dental Dressing (HDD; HemCon Medical Technologies, Inc, Beaverton, OR) hemostatic oral wound dressing derived from the US military HemCon Bandage combat wound dressing and whether early hemostasis affects postoperative care and surgical healing outcomes following oral surgical procedures. PATIENTS AND METHODS: All patients aged 18 to 90, except those allergic to seafood, who consented to participate were eligible for enrollment into this study regardless of other medical history findings. All patients were required to have 2 or more surgical sites so they would have internal surgical control sites. All patients taking oral anticoagulation therapy (OAT) were included for treatment in this study without altering their anticoagulant medication regimens. All data were evaluated by biomedical statisticians and Institutional Review Board approval was obtained. RESULTS: All HDD surgically treated sites, including all from patients taking OAT, achieved hemostasis in less than 1 minute and control wounds in 9.53 minutes (P < .001). All HDD sites achieved hemostasis sooner than control sites (P <.001). Approximately 32% of HDD treated sites had significantly better healing compared with control sites (P <.020) and no control sites healed better than HDD treated sites; 32% of HDD treated oral surgery wounds achieved statistically significant improved healing (P <.001). All patients taking OAT achieved hemostasis within 1 minute and were treated without altering their anticoagulant regimens. Although the pain scores and incidence of alveolar osteitis were lower for the HDD-treated sites, these scores were not significantly different than control-treated sites. There was no negative healing sequela associated with early hemostasis of oral surgical wounds. CONCLUSION: The HDD has been proven to be a clinically effective hemostatic device that significantly shortens bleeding time following oral surgery procedures for all patients, including those patients taking OAT. Patients receiving the HDD had improved surgical wound healing compared with those receiving controls. FAU - Malmquist, Jay P AU - Malmquist JP FAU - Clemens, Stephen C AU - Clemens SC FAU - Oien, Hal J AU - Oien HJ FAU - Wilson, Sharon L AU - Wilson SL LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anticoagulants) RN - 0 (Hemostatics) RN - 9012-76-4 (Chitosan) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Anticoagulants/therapeutic use MH - Chitosan/*therapeutic use MH - *Dental Care for Chronically Ill MH - Dry Socket/etiology MH - Female MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Occlusive Dressings MH - Oral Hemorrhage/*prevention & control MH - Periodontal Dressings MH - Postoperative Hemorrhage/*prevention & control MH - *Tooth Extraction/adverse effects EDAT- 2008/05/20 09:00 MHDA- 2008/06/17 09:00 CRDT- 2008/05/20 09:00 PHST- 2008/05/20 09:00 [pubmed] PHST- 2008/06/17 09:00 [medline] PHST- 2008/05/20 09:00 [entrez] AID - S0278-2391(07)02188-X [pii] AID - 10.1016/j.joms.2007.12.023 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2008 Jun;66(6):1177-83. doi: 10.1016/j.joms.2007.12.023. PMID- 32613433 OWN - NLM STAT- MEDLINE DCOM- 20210215 LR - 20210215 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 25 IP - 3 DP - 2021 Mar TI - Evaluation of local hemostatic efficacy after dental extractions in patients taking antiplatelet drugs: a randomized clinical trial. PG - 1159-1167 LID - 10.1007/s00784-020-03420-3 [doi] AB - OBJECTIVES: The purpose of this study was to evaluate clinical efficacy of four different local hemostatics in patients taking oral antiplatelet therapy, after multiple dental extractions without discontinuing drugs. MATERIALS AND METHODS: Study sample included 102 patients (mean age 64.1 ± 17.4 years) in treatment with oral antiplatelet agents needing multiple dental extractions. After surgery, the sockets were randomly sealing with suture alone (control group), hemostatic plug (HEM), advanced platelet-rich fibrin (A-PRF+), and leukocyte-platelet-rich fibrin (L-PRF). Primary outcomes were post-operative bleeding, wound healing index, and possible complications. Secondary outcomes were correlation between primary outcomes and patient's comorbidities and voluptuous habits. Descriptive statistics, bivariate comparisons, and logistic regression analysis were performed (p < 0.05). RESULTS: Both A-PRF+ and L-PRF showed a reduced bleeding risk when compared with suture alone (OR = 0.09, p = 0.001 for A-PRF+; OR = 0.09, p = 0.005 for L-PRF). Only L-PRF showed a reduced risk for incomplete wound healing when compared with the control site (OR = 0.43, p = 0.019). Patients affected by hypertension (OR 3.91, p = 0.015) and diabetes (OR 3.24, p = 0.026) had the highest bleeding risk. Smoking (OR 4.30, p = 0.016) and diabetes (OR 3.79, p = 0.007) interfered with healing process. CONCLUSION: L-PRF and A-PRF represent a valid alternative to the traditional hemostatics, reducing post-surgical bleeding and promoting wound healing. CLINICAL RELEVANCE: In patients taking antiplatelet drugs, different local hemostatics are useful to control potential post-operative bleeding and to favor wound healing. However, comorbidities and voluptuous habits may increase bleeding risk, interfering with healing process. FAU - Brancaccio, Ylenia AU - Brancaccio Y AD - Department of Health Sciences, School of Dentistry, Magna Graecia University of Catanzaro, Catanzaro, Italy. FAU - Antonelli, Alessandro AU - Antonelli A AD - Department of Health Sciences, School of Dentistry, Magna Graecia University of Catanzaro, Catanzaro, Italy. FAU - Barone, Selene AU - Barone S AD - Department of Health Sciences, School of Dentistry, Magna Graecia University of Catanzaro, Catanzaro, Italy. FAU - Bennardo, Francesco AU - Bennardo F AD - Department of Health Sciences, School of Dentistry, Magna Graecia University of Catanzaro, Catanzaro, Italy. FAU - Fortunato, Leonzio AU - Fortunato L AD - Department of Health Sciences, School of Dentistry, Magna Graecia University of Catanzaro, Catanzaro, Italy. FAU - Giudice, Amerigo AU - Giudice A AUID- ORCID: 0000-0002-5091-6979 AD - Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. a.giudice@unicz.it. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200701 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Hemostatics) RN - 0 (Platelet Aggregation Inhibitors) SB - D MH - Aged MH - Aged, 80 and over MH - *Hemostatics/therapeutic use MH - Humans MH - Middle Aged MH - Platelet Aggregation Inhibitors/therapeutic use MH - *Platelet-Rich Fibrin MH - Tooth Extraction MH - Wound Healing OTO - NOTNLM OT - A-PRF OT - Antiplatelet therapy OT - Dental extractions OT - Hemostatic agents OT - L-PRF OT - Wound healing EDAT- 2020/07/03 06:00 MHDA- 2021/02/16 06:00 CRDT- 2020/07/03 06:00 PHST- 2020/04/25 00:00 [received] PHST- 2020/06/17 00:00 [accepted] PHST- 2020/07/03 06:00 [pubmed] PHST- 2021/02/16 06:00 [medline] PHST- 2020/07/03 06:00 [entrez] AID - 10.1007/s00784-020-03420-3 [pii] AID - 10.1007/s00784-020-03420-3 [doi] PST - ppublish SO - Clin Oral Investig. 2021 Mar;25(3):1159-1167. doi: 10.1007/s00784-020-03420-3. Epub 2020 Jul 1. PMID- 28189659 OWN - NLM STAT- MEDLINE DCOM- 20170830 LR - 20170830 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 75 IP - 6 DP - 2017 Jun TI - The Use of a Chitosan-Derived Hemostatic Agent for Postextraction Bleeding Control in Patients on Antiplatelet Treatment. PG - 1118-1123 LID - S0278-2391(17)30074-5 [pii] LID - 10.1016/j.joms.2017.01.005 [doi] AB - PURPOSE: The current approach for tooth extraction in patients receiving antiplatelet treatment requires the use of local hemostatic agents without previous thromboembolic treatment interruption. The aim of the present study was to evaluate the effectiveness of an extra-alveolar hemostatic agent, the HemCon Dental Dressing (HDD), in controlling postsurgical bleeding. MATERIALS AND METHODS: Routine, atraumatic tooth extractions were performed in a single session under local anesthesia without a vasoconstrictor and without interruption of antiplatelet therapy. All patients underwent extraction of 2 teeth in the same session, with each in a different dental hemi-arch, and the hemostatic method to be used was randomly chosen: in the test site, the HDD was applied, whereas in the control site, a common hemostatic sponge (CollaPlug, Zimmer Dental) was applied and stabilized in situ with a suture. For each surgery, 2 different times were measured: the time required for hemostatic agent application and the time required for hemostasis achievement. Postoperative pain and healing quality also were evaluated. RESULTS: Twenty outpatients were enrolled. The mean application time was considerably shorter in the test group than in the control group; the mean bleeding time in the control group was considerably shorter than in the test group; pain values were lower in the test group than in the control group, especially at suture removal; and postextraction socket healing was better in the test group than in the control group. CONCLUSION: HDD seems to be a valid and safe alternative in treating postextraction sockets in outpatients under single-drug antiplatelet treatment in the absence of surgical wound lacerations. CI - Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Pippi, Roberto AU - Pippi R AD - Associate Professor, Department of Odontostomatological and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy. FAU - Santoro, Marcello AU - Santoro M AD - PhD Student, Department of Odontostomatological and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: marcello.santoro@uniroma1.it. FAU - Cafolla, Arturo AU - Cafolla A AD - Assistant Professor, Department of Cell Biotechnology and Hematology, "Sapienza" University of Rome, Rome, Italy. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170118 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Hemostatics) RN - 0 (Platelet Aggregation Inhibitors) RN - 9012-76-4 (Chitosan) SB - AIM SB - D SB - IM MH - Aged MH - Aged, 80 and over MH - Chitosan/*therapeutic use MH - Female MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/*prevention & control MH - Pain Measurement MH - Pain, Postoperative MH - Platelet Aggregation Inhibitors/*therapeutic use MH - *Tooth Extraction MH - Treatment Outcome MH - Wound Healing EDAT- 2017/02/13 06:00 MHDA- 2017/08/31 06:00 CRDT- 2017/02/13 06:00 PHST- 2016/11/09 00:00 [received] PHST- 2017/01/09 00:00 [accepted] PHST- 2017/02/13 06:00 [pubmed] PHST- 2017/08/31 06:00 [medline] PHST- 2017/02/13 06:00 [entrez] AID - S0278-2391(17)30074-5 [pii] AID - 10.1016/j.joms.2017.01.005 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2017 Jun;75(6):1118-1123. doi: 10.1016/j.joms.2017.01.005. Epub 2017 Jan 18. PMID- 32554068 OWN - NLM STAT- MEDLINE DCOM- 20201110 LR - 20201112 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 11 DP - 2020 Nov TI - Does the Low-Intensity Laser Protocol Affect Tissue Healing After Third Molar Removal? PG - 1920.e1-1920.e9 LID - S0278-2391(20)30485-7 [pii] LID - 10.1016/j.joms.2020.05.018 [doi] AB - PURPOSE: Studies have shown that laser therapy is a recommended therapy for improving the postoperative period in patients undergoing extraction of the third molars; however, there is still no definition regarding the best protocol to be used. The aim of this study was to measure and compare periodontal tissue healing using 2 different laser protocols. MATERIALS AND METHODS: A double-blinded, randomized, prospective study with patients submitted to inferior third molar extraction was performed, with the sample divided into 3 groups according to the laser application protocol and followed for 6 months: group I, 10 J/cm(2); group II, 30 J/cm(2); and group III, sham. The primary variable was probing depth, and the secondary variables were trismus, facial edema, and pain. RESULTS: The sample was composed of 57 patients: 19 in group I, 20 in group II, and 18 in group III. Analysis of the variables showed statistically significant differences between both groups that received laser therapy, with values of 1.46 for edema control on the third day and 0.54 on the seventh day in group I (P = .017) and 1.26 and 0.52, respectively, in group II (P = .001) compared with 0.59 and 0.49, respectively, in the sham group (P = .702), as well as a statistically significant difference for the 10-J/cm(2) laser protocol for probing depth, with values of 7.58 mm preoperatively and 9.09 mm after 6 months (P = .013). CONCLUSIONS: The use of the low-intensity laser as adjuvant therapy after third molar extraction was more effective in the group undergoing the 10-J/cm(2) laser protocol for improving periodontal tissue healing and in both laser therapy groups for reducing facial edema. CI - Copyright © 2020 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Bianchi de Moraes, Michelle AU - Bianchi de Moraes M AD - Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Diagnosis and Surgery, State University of São Paulo (UNESP), College of Dentistry, São José dos Campos, Brazil. FAU - Gomes de Oliveira, Rúbia AU - Gomes de Oliveira R AD - MS Student, Oral and Maxillofacial Surgery Area, Department of Diagnosis and Surgery, State University of São Paulo (UNESP), College of Dentistry, São José dos Campos, Brazil. FAU - Raldi, Fernando Vagner AU - Raldi FV AD - Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Diagnosis and Surgery, State University of São Paulo (UNESP), College of Dentistry, São José dos Campos, Brazil. FAU - Nascimento, Rodrigo Dias AU - Nascimento RD AD - Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Diagnosis and Surgery, State University of São Paulo (UNESP), College of Dentistry, São José dos Campos, Brazil. FAU - Santamaria, Mauro Pedrine AU - Santamaria MP AD - Assistant Professor, Division of Periodontics, Department of Diagnosis and Surgery, State University of São Paulo (UNESP), College of Dentistry, São José dos Campos, Brazil. FAU - Loureiro Sato, Fábio Ricardo AU - Loureiro Sato FR AD - Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Diagnosis and Surgery, State University of São Paulo (UNESP), College of Dentistry, São José dos Campos, Brazil. Electronic address: fabio.sato@ict.unesp.br. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200519 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Edema/etiology MH - Humans MH - *Molar, Third/surgery MH - Pain, Postoperative MH - Prospective Studies MH - Tooth Extraction MH - *Tooth, Impacted/surgery MH - Trismus EDAT- 2020/06/20 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/06/20 06:00 PHST- 2019/08/06 00:00 [received] PHST- 2020/04/14 00:00 [revised] PHST- 2020/05/06 00:00 [accepted] PHST- 2020/06/20 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/06/20 06:00 [entrez] AID - S0278-2391(20)30485-7 [pii] AID - 10.1016/j.joms.2020.05.018 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Nov;78(11):1920.e1-1920.e9. doi: 10.1016/j.joms.2020.05.018. Epub 2020 May 19. PMID- 28403362 OWN - NLM STAT- MEDLINE DCOM- 20170530 LR - 20181113 IS - 1678-7765 (Electronic) IS - 1678-7757 (Print) IS - 1678-7757 (Linking) VI - 25 IP - 2 DP - 2017 Mar-Apr TI - Effects of hyaluronic acid on bleeding following third molar extraction. PG - 211-216 LID - S1678-77572017000200211 [pii] LID - 10.1590/1678-77572015-0187 [doi] AB - OBJECTIVE: To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction. METHODS: Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups. RESULTS: HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group. CONCLUSIONS: Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions. FAU - Gocmen, Gokhan AU - Gocmen G AD - Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey. FAU - Aktop, Sertac AU - Aktop S AD - Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey. FAU - Tüzüner, Burcin AU - Tüzüner B AD - Marmara University, Faculty of Dentistry, Department of Biochemistry, Istanbul, Turkey. FAU - Goker, Bahar AU - Goker B AD - Marmara University, Faculty of Pharmacy, Department of Biochemistry, Istanbul, Turkey. FAU - Yarat, Aysen AU - Yarat A AD - Marmara University, Faculty of Dentistry, Department of Biochemistry, Istanbul, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial TA - J Appl Oral Sci JT - Journal of applied oral science : revista FOB JID - 101189774 RN - 0 (Anti-Inflammatory Agents) RN - 9004-61-9 (Hyaluronic Acid) RN - 9035-58-9 (Thromboplastin) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*adverse effects MH - Bleeding Time MH - Gingiva/chemistry MH - Humans MH - Hyaluronic Acid/*adverse effects MH - Molar, Third/*surgery MH - Pain Measurement MH - Postoperative Hemorrhage/*chemically induced MH - Prospective Studies MH - Reference Values MH - Saliva/chemistry MH - Statistics, Nonparametric MH - Thromboplastin/analysis MH - Time Factors MH - Tooth Extraction/*adverse effects/methods MH - Treatment Outcome MH - Wound Healing/drug effects MH - Young Adult PMC - PMC5393542 EDAT- 2017/04/14 06:00 MHDA- 2017/05/31 06:00 CRDT- 2017/04/14 06:00 PHST- 2016/08/22 00:00 [received] PHST- 2016/12/28 00:00 [accepted] PHST- 2017/04/14 06:00 [entrez] PHST- 2017/04/14 06:00 [pubmed] PHST- 2017/05/31 06:00 [medline] AID - S1678-77572017000200211 [pii] AID - 1678-77572015-0187 [pii] AID - 10.1590/1678-77572015-0187 [doi] PST - ppublish SO - J Appl Oral Sci. 2017 Mar-Apr;25(2):211-216. doi: 10.1590/1678-77572015-0187. PMID- 32682735 OWN - NLM STAT- MEDLINE DCOM- 20201110 LR - 20201110 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 11 DP - 2020 Nov TI - Effect of an Informative Video on Anxiety and Hemodynamic Parameters in Patients Requiring Mandibular Third Molar Extraction: A Randomized Clinical Trial. PG - 1933-1941 LID - S0278-2391(20)30667-4 [pii] LID - 10.1016/j.joms.2020.06.024 [doi] AB - PURPOSE: The purpose was to determine the effect of watching an informative video about mandibular third molar (M3M) removal on patient anxiety and hemodynamic parameters. PATIENTS AND METHODS: A randomized controlled clinical trial was carried out in healthy patients (aged between 18 and 40 years) requiring M3M extraction under local anesthesia. Patients with previous tooth extractions, psychiatric disorders, or cardiac problems or patients undergoing anxiolytic or antidepressant drug treatment were excluded. Participants were randomized into 2 groups according to whether they watched an informative video about the surgical procedure (video group) or not (control group). The primary outcome variable was the difference between groups regarding patient anxiety assessed with the State-Trait Anxiety Inventory (STAI) and the Modified Dental Anxiety Scale (MDAS). The secondary outcome variables were hemodynamic parameters recorded during different moments of the surgical procedure. Descriptive, bivariate, and multivariate analyses were performed, and a repeated-measures mixed model was generated. Statistical significance was considered for P < .05. RESULTS: Fifty patients referred for M3M extraction met the inclusion criteria. The final data analysis was based on 47 patients: 25 from the video group and 22 controls. The bivariate analysis showed the video group to have a significant decrease in anxiety as measured by the MDAS (P = .006; 95% confidence interval [CI], -4.1 to -0.7) and STAI-State (P = .003; 95% CI, -13.7 to -0.7). A significantly lower heart rate was likewise found in the video group (χ(2) = 4.30, df = 1, P = .038). The linear regression analysis adjusting for the STAI-Trait also showed lower dental anxiety measured by the MDAS in the video group (P = .023; 95% CI, 0.32 to 4.14). CONCLUSIONS: Providing preoperative information through an informative video about M3M removal significantly reduces patient anxiety and heart rate during the surgical procedure. CI - Copyright © 2020 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Toledano-Serrabona, Jorge AU - Toledano-Serrabona J AD - Fellow of the Master Degree of Oral Surgery and Implantology, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. FAU - Sánchez-Torres, Alba AU - Sánchez-Torres A AD - Associate Professor of Oral Surgery, Master Degree Program in Oral Surgery and Implantology, School of Medicine and Health Sciences, University of Barcelona; and Researcher at IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain. FAU - Camps-Font, Octavi AU - Camps-Font O AD - Associate Professor of Oral Surgery, Master Degree Program in Oral Surgery and Implantology, School of Medicine and Health Sciences, University of Barcelona; and Researcher at IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain. FAU - Figueiredo, Rui AU - Figueiredo R AD - Lecturer in Oral Surgery and Coordinator of the Master Degree Program in Oral Surgery and Implantology, School of Medicine and Health Sciences, University of Barcelona; and Researcher at IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain. Electronic address: ruipfigueiredo@hotmail.com. FAU - Gay-Escoda, Cosme AU - Gay-Escoda C AD - Chairman and Professor of Oral and Maxillofacial Surgery, School of Medicine and Health Sciences, University of Barcelona; Director of the Master Degree Program in Oral Surgery and Implantology, EFHRE International University/FUCSO (Fundacio Catalana per a la Salut Oral); Coordinator/Researcher at IDIBELL (Bellvitge Biomedical Research Institute); and Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department, Teknon Medical Center, Barcelona, Spain. FAU - Valmaseda-Castellón, Eduard AU - Valmaseda-Castellón E AD - Senior Lecturer in Oral Surgery and Director of the Master Degree Program in Oral Surgery and Implantology, School of Medicine and Health Sciences, University of Barcelona; and Researcher at IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200622 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Anxiety/prevention & control MH - Dental Anxiety/prevention & control MH - Hemodynamics MH - Humans MH - *Molar, Third/surgery MH - Tooth Extraction MH - *Tooth, Impacted MH - Young Adult EDAT- 2020/07/20 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/07/20 06:00 PHST- 2020/04/13 00:00 [received] PHST- 2020/05/21 00:00 [revised] PHST- 2020/06/15 00:00 [accepted] PHST- 2020/07/20 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/07/20 06:00 [entrez] AID - S0278-2391(20)30667-4 [pii] AID - 10.1016/j.joms.2020.06.024 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Nov;78(11):1933-1941. doi: 10.1016/j.joms.2020.06.024. Epub 2020 Jun 22. PMID- 32436160 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20201221 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 24 IP - 12 DP - 2020 Dec TI - Effect of orally administered magnesium on postoperative pain level and trismus after surgical removal of the lower third molars: a randomized, double-blind, placebo-controlled trial. PG - 4649-4659 LID - 10.1007/s00784-020-03335-z [doi] AB - OBJECTIVES: Pain and trismus are the most common postoperative complications following a surgical removal of the lower third molar. This randomized, double-blind, placebo-controlled clinical trial evaluated the effect of orally administrated magnesium on postoperative pain and trismus after surgical removal of the lower third molars. MATERIALS AND METHODS: The study was conducted on 80 participants who were divided into two groups. Each group took different oral forms of magnesium citrate. Participants in both groups had their two lower molars surgically removed. For one randomly selected third molar, participants received either magnesium citrate tablets or lozenges. For the surgical removal of the lower third molar of the opposite side, the participants received either placebo tablets or lozenges. The data were analyzed using the Wilcoxon signed-ranked test, the Mann-Whitney U test, and the Spearman rank-order correlation with the level of significance set at p < 0.05. This manuscript was written in accordance with the Consort recommendation. RESULTS: The results show a statistically significant lower pain level at all tested times (24 h, 48 h, and 72 h postoperatively) for participants who used magnesium preparations in lozenges (p = 0.012, p = 0.013, and p ≤ 0.001) as well as in tablet form (p ≤ 0.001) compared to placebo. The results also show a statistically significant greater mouth opening ability at all tested times (24 h, 48 h, and 72 h postoperatively) between magnesium preparations and the placebo (p ≤ 0.001). CONCLUSION: Orally administered magnesium (either lozenges or tablets) before and after a lower third molar surgical removal significantly reduces pain intensity and the degree of trismus in the postoperative period. CLINICAL RELEVANCE: Based on the results of the study, oral magnesium could be used in the oral and maxillofacial surgery to reduce postoperative complications after surgical removal of the lower third molars. TRIAL REGISTRATION: This study is registered on http:clinicaltrials.gov under protocol no. NCT03398382. FAU - Jerkovic, Daniel AU - Jerkovic D AUID- ORCID: 0000-0001-5624-1944 AD - Department of Maxillofacial Surgery, Study of Dental Medicine, School of Medicine, Clinical Hospital Centre, University of Split, Spinciceva 1, 21000, Split, Croatia. djerkovic@sfzg.hr. FAU - Tadin, Antonija AU - Tadin A AD - Department of Restorative Dental Medicine and Endodontics, Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia. FAU - Gavic, Lidia AU - Gavic L AD - Department for Oral Medicine and Periodontology, Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia. FAU - Vladislavic, Nada Zorica AU - Vladislavic NZ AD - School of Dental Medicine, University of Zagreb, Zagreb, Croatia. FAU - Grgic, Nino AU - Grgic N AD - School of Dental Medicine, University of Zagreb, Zagreb, Croatia. FAU - Macan, Darko AU - Macan D AD - Department of Maxillofacial and Oral Surgery, School of Dental Medicine, University of Zagreb, University Hospital Dubrava, Zagreb, Croatia. LA - eng SI - ClinicalTrials.gov/NCT03398382 PT - Journal Article PT - Randomized Controlled Trial DEP - 20200520 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - I38ZP9992A (Magnesium) SB - D MH - Double-Blind Method MH - Edema MH - Humans MH - Magnesium MH - *Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - Tooth Extraction MH - *Tooth, Impacted/surgery MH - Trismus/prevention & control OTO - NOTNLM OT - Magnesium citrate OT - Pain OT - Surgical removal of third molar OT - Third molar OT - Trismus EDAT- 2020/05/22 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/05/22 06:00 PHST- 2020/01/30 00:00 [received] PHST- 2020/05/08 00:00 [accepted] PHST- 2020/05/22 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/05/22 06:00 [entrez] AID - 10.1007/s00784-020-03335-z [pii] AID - 10.1007/s00784-020-03335-z [doi] PST - ppublish SO - Clin Oral Investig. 2020 Dec;24(12):4649-4659. doi: 10.1007/s00784-020-03335-z. Epub 2020 May 20. PMID- 30457557 OWN - NLM STAT- MEDLINE DCOM- 20190725 LR - 20200225 IS - 2148-5607 (Electronic) IS - 1300-4948 (Print) IS - 1300-4948 (Linking) VI - 30 IP - 2 DP - 2019 Feb TI - Prospective randomized single-blind study of post-operative bleeding after minor oral surgery in patients with cirrhosis. PG - 171-176 LID - 10.5152/tjg.2018.18078 [doi] AB - BACKGROUND/AIMS: The management of patients with cirrhosis requiring dental extractions is complicated due to an increased risk of post-operative bleeding. Topical hemostatic agents are usually required to control bleeding in these cases, as an adjunct to systemic measures of hemostasis. The aims of this randomized, prospective, single-blind clinical study are twofold. The primary aim is to compare the hemostatic efficacy of chitosan and surgicel in patients with cirrhosis after a tooth extraction, and the secondary aim is to assess the value of the current setting as a clinical model of post-operative bleeding following minor oral surgery. MATERIAL AND METHODS: Fifty patients with cirrhosis scheduled for a tooth extraction under local anesthesia were prospectively included in the study in a randomized fashion. Patients were blinded to the treatment group they were in. The cirrhosis classification, bleeding time, trauma score, and corrected bleeding time (during post-operative reviews) were recorded. Statistical evaluations were done. RESULTS: Study groups had an equal number of teeth extractions (40 teeth each). There were no statistically significant differences between the groups with respect to patient demographics, cirrhosis classification, trauma score, and bleeding time. No side effects were noted. CONCLUSION: Both Celox and Surgicel are effective for controlling bleeding and are safe after a tooth extraction in patients with cirrhosis. FAU - Efeoğlu, Candan AU - Efeoğlu C AD - Department of Oral Surgery, Ege University School of Dentistry, İzmir, Turkey. FAU - Sipahi Çalış, Aylin AU - Sipahi Çalış A AD - Department of Oral Surgery, Ege University School of Dentistry, İzmir, Turkey. FAU - Karasu, Zeki AU - Karasu Z AD - Department of Gastroenterology, Ege University School of Medicine, İzmir, Turkey. FAU - Koca, Hüseyin AU - Koca H AD - Department of Oral Surgery, Ege University School of Dentistry, İzmir, Turkey. FAU - Boyacıoğlu, Hayal AU - Boyacıoğlu H AD - Department of Statistics, Ege University School of Science, İzmir, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial TA - Turk J Gastroenterol JT - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JID - 9515841 RN - 0 (Biopolymers) RN - 0 (Cellulose, Oxidized) RN - 0 (Celox) RN - 0 (Hemostatics) RN - 82347-53-3 (Surgicel) MH - Adolescent MH - Adult MH - Aged MH - Biopolymers/*administration & dosage MH - Cellulose, Oxidized/*administration & dosage MH - Female MH - Hemostatics/*administration & dosage MH - Humans MH - Liver Cirrhosis/*complications MH - Male MH - Middle Aged MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Prospective Studies MH - Single-Blind Method MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Young Adult PMC - PMC6408173 COIS- Conflict of Interest: The authors have no conflicts of interest to declare. EDAT- 2018/11/21 06:00 MHDA- 2019/07/26 06:00 CRDT- 2018/11/21 06:00 PHST- 2018/11/21 06:00 [pubmed] PHST- 2019/07/26 06:00 [medline] PHST- 2018/11/21 06:00 [entrez] AID - tjg-30-2-171 [pii] AID - 10.5152/tjg.2018.18078 [doi] PST - ppublish SO - Turk J Gastroenterol. 2019 Feb;30(2):171-176. doi: 10.5152/tjg.2018.18078. PMID- 33187948 OWN - NLM STAT- MEDLINE DCOM- 20210419 LR - 20210419 IS - 2212-4411 (Electronic) VI - 131 IP - 3 DP - 2021 Mar TI - Do perioperative antibiotics reduce complications of mandibular third molar removal? A double-blind randomized controlled clinical trial. PG - 286-294 LID - S2212-4403(20)31201-3 [pii] LID - 10.1016/j.oooo.2020.08.034 [doi] AB - OBJECTIVE: The aim of this study was to compare the effects of different antibiotic prophylaxis regimens versus placebo in relation to possible postoperative complications derived from the surgical extraction of impacted lower third molars. STUDY DESIGN: The final study sample of this double-blind randomized controlled trial comprised 92 Caucasian volunteers. Patients were assigned to 3 groups by using a randomization table. Group 1 (n = 30) received 750 mg oral amoxicillin both before and after the surgery; group 2 (n = 32) received the same oral dose after surgery alone; and group 3 (n = 30) received placebo both before and after surgery. Infectious complications, postoperative pain, and inflammation intensity were measured. The requirement for and the timing of rescue medication were also measured. RESULTS: Postoperative pain and inflammation intensity were significantly higher (P < .05) in group 3 than in groups 1 or 2 at 48 hours, 72 hours, and 1 week. A significantly higher proportion of group 3 required rescue medication (analgesics and rescue antibiotics) (P = .013) compared with groups 1 or 2. CONCLUSIONS: Greater pain and inflammation were experienced by patients receiving placebo before lower third molar extraction than by those receiving antibiotics either before surgery or both before and after surgery. Other options, such as use of local antibiotics, should be considered to reduce the problems, including bacterial resistance, caused by overuse of systemic antibiotics. CI - Copyright © 2020 Elsevier Inc. All rights reserved. FAU - Mariscal-Cazalla, Maria Del Mar AU - Mariscal-Cazalla MDM AD - Student, Department of Oral and Maxillofacial Surgery, University of Granada, Spain. FAU - Manzano-Moreno, Francisco J AU - Manzano-Moreno FJ AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Granada, Spain. Electronic address: Fjmanza@ugr.es. FAU - García-Vázquez, Marta AU - García-Vázquez M AD - Student, Department of Oral and Maxillofacial Surgery, University of Granada, Spain. FAU - Vallecillo-Capilla, Manuel F AU - Vallecillo-Capilla MF AD - Professor, Department of Oral and Maxillofacial Surgery; Director, Oral Surgery and Implantology Masters Clinic, University of Granada, Spain. FAU - Olmedo-Gaya, Maria Victoria AU - Olmedo-Gaya MV AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Granada, Spain. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200909 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anti-Bacterial Agents) SB - D SB - IM MH - Anti-Bacterial Agents/therapeutic use MH - Double-Blind Method MH - Humans MH - Mandible/surgery MH - *Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - Tooth Extraction MH - *Tooth, Impacted/surgery EDAT- 2020/11/15 06:00 MHDA- 2021/04/20 06:00 CRDT- 2020/11/14 05:23 PHST- 2020/03/15 00:00 [received] PHST- 2020/06/28 00:00 [revised] PHST- 2020/08/31 00:00 [accepted] PHST- 2020/11/15 06:00 [pubmed] PHST- 2021/04/20 06:00 [medline] PHST- 2020/11/14 05:23 [entrez] AID - S2212-4403(20)31201-3 [pii] AID - 10.1016/j.oooo.2020.08.034 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Mar;131(3):286-294. doi: 10.1016/j.oooo.2020.08.034. Epub 2020 Sep 9. PMID- 32068167 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20201221 IS - 2468-7855 (Electronic) IS - 2468-7855 (Linking) VI - 121 IP - 6 DP - 2020 Dec TI - Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial. PG - 646-651 LID - S2468-7855(20)30038-0 [pii] LID - 10.1016/j.jormas.2020.02.004 [doi] AB - BACKGROUND: The aim of this study was to investigate the effects of concentrated growth factors (CGF) and advanced platelet-rich fibrin (A-PRF) on edema, pain, and trismus after mandibular third molar surgery. MATERIAL AND METHODS: Patients were randomly divided into A-PRF, CGF and control groups. After extraction of the third molars, A-PRF and CGF were prepared and applied to the extraction sockets in study groups, while nothing was applied to the control group. Edema was measured from 5 reference points, including tragus, labial commissure, soft tissue pogonion, lateral corner of the eye/lateral canthus and angulus mandible. Trismus measured as the distance between the right lower and upper central incisors. Trismus and edema were measured preoperatively, and on postoperative 2nd and 7th days. Pain evaluated using the visual analogue scale (VAS) between 6th hour and 7th day after surgery. RESULTS: A total of 75 patients, 25 in each group, were included in the study. The change in tragus to labial commissure measurements showed a significant difference between baseline-7th days among control and CGF groups (P=0.038). Significant differences observed between the tragus to pogonion measurements at baseline-7th days among the control-CGF groups (P=0.014), and A-PRF-CGF groups (P=0.038). Secondary outcome variables trismus, pain, and analgesic consumption showed no significant differences among the groups (P>0.05). CONCLUSIONS: Based on the results of this study, it can be concluded that A-PRF and CGF seem to have no positive effects on pain, edema, and trismus after third molar surgery. CI - Copyright © 2020 Elsevier Masson SAS. All rights reserved. FAU - Torul, D AU - Torul D AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey. Electronic address: damlatorul@gmail.com. FAU - Omezli, M M AU - Omezli MM AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey. FAU - Kahveci, K AU - Kahveci K AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200214 PL - France TA - J Stomatol Oral Maxillofac Surg JT - Journal of stomatology, oral and maxillofacial surgery JID - 101701089 RN - 9001-31-4 (Fibrin) SB - D SB - IM MH - Edema/etiology/prevention & control MH - Fibrin MH - Humans MH - Molar, Third/surgery MH - Pain, Postoperative/diagnosis/drug therapy/etiology MH - *Platelet-Rich Fibrin MH - *Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control OTO - NOTNLM OT - Pain OT - Platelet-rich biomaterials OT - Swelling OT - Third molar surgery OT - Trismus EDAT- 2020/02/19 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/02/19 06:00 PHST- 2019/11/26 00:00 [received] PHST- 2020/02/06 00:00 [revised] PHST- 2020/02/06 00:00 [accepted] PHST- 2020/02/19 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/02/19 06:00 [entrez] AID - S2468-7855(20)30038-0 [pii] AID - 10.1016/j.jormas.2020.02.004 [doi] PST - ppublish SO - J Stomatol Oral Maxillofac Surg. 2020 Dec;121(6):646-651. doi: 10.1016/j.jormas.2020.02.004. Epub 2020 Feb 14. PMID- 29625028 OWN - NLM STAT- MEDLINE DCOM- 20190718 LR - 20190718 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 76 IP - 8 DP - 2018 Aug TI - Effectiveness of Drainage in Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis. PG - 1640-1650 LID - S0278-2391(18)30214-3 [pii] LID - 10.1016/j.joms.2018.03.004 [doi] AB - PURPOSE: The purpose of this study was to provide an evidence-based evaluation of the impact of surgical drainage after the removal of mandibular third molars. MATERIALS AND METHODS: The Medline (PubMed), Cochrane Library, and Web of Science databases were searched to identify randomized controlled trials up to September 1, 2017. Postoperative variables, including facial swelling, trismus, and pain, were calculated early (2 to 3 days) and late (5 to 7 days) after the removal of impacted mandibular third molars. Weighted mean differences for trismus and standardized mean differences (SMDs) for swelling and pain were pooled for the included studies. RESULTS: The samples consisted of 592 extractions (297 with surgical drainage and 295 controls) in 409 participants. The included studies were published from 1988 to 2016. Participants who received surgical drainage had significantly less facial swelling during the early stage (SMD, -0.46; 95% confidence interval [CI], -0.67 to -0.26; P < .0001) and the late stage (SMD, -0.36; 95% CI, -0.55 to -0.16; P = .0004) after the removal of an impacted mandibular third molar. They also had better mouth opening than controls during the early and late stages (early MD, 5.55 mm; 95% CI, 2.31-8.79; P = .0008; late MD, 2.38 mm; 95% CI, 1.47-3.29; P < .0001). The level of pain was significantly different between the 2 groups in the early stage (SMD, -0.55; 95% CI, -1.00 to -0.10; P = .01); however, there were no significant differences in the late stage (SMD, -0.13; 95% CI, -0.38 to 0.12; P = .30). CONCLUSION: The use of surgical drainage has an obviously positive effect on postoperative reactions after the removal of a mandibular third molar. Given the need for additional time for clinic visits, surgical drainage presents an alternative for the perioperative management of impacted mandibular third molar surgery, especially in cases of a fully bony tooth with poor drainage. CI - Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Liu, Shaopeng AU - Liu S AD - Resident, College of Stomatology, Shandong University, Jinan, Shandong, China. FAU - You, Zhu AU - You Z AD - Resident, College of Stomatology, Shandong University, Jinan, Shandong, China. FAU - Ma, Chuan AU - Ma C AD - Resident, College of Stomatology, Shandong University, Jinan, Shandong, China. FAU - Wang, Ye AU - Wang Y AD - Resident, College of Stomatology, Shandong University, Jinan, Shandong, China. FAU - Zhao, Huaqiang AU - Zhao H AD - Professor, College of Stomatology, Shandong University, Jinan, Shandong, China. Electronic address: zhaohq@sdu.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20180315 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Drainage/*methods MH - Edema MH - Humans MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative MH - Postoperative Complications/*prevention & control MH - Randomized Controlled Trials as Topic MH - Tooth, Impacted/*surgery MH - Trismus EDAT- 2018/04/07 06:00 MHDA- 2019/07/19 06:00 CRDT- 2018/04/07 06:00 PHST- 2017/11/16 00:00 [received] PHST- 2018/03/06 00:00 [revised] PHST- 2018/03/06 00:00 [accepted] PHST- 2018/04/07 06:00 [pubmed] PHST- 2019/07/19 06:00 [medline] PHST- 2018/04/07 06:00 [entrez] AID - S0278-2391(18)30214-3 [pii] AID - 10.1016/j.joms.2018.03.004 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2018 Aug;76(8):1640-1650. doi: 10.1016/j.joms.2018.03.004. Epub 2018 Mar 15. PMID- 31016540 OWN - NLM STAT- MEDLINE DCOM- 20200206 LR - 20210123 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 24 IP - 1 DP - 2020 Jan TI - Efficacy and safety of selective COX-2 inhibitors for pain management after third molar removal: a meta-analysis of randomized clinical trials. PG - 79-96 LID - 10.1007/s00784-019-02910-3 [doi] AB - OBJECTIVES: To compare selective COX-2 inhibitors with ibuprofen in terms of analgesia, rescue medication consumption, and adverse effects after impacted third molar removal. MATERIALS AND METHODS: Electronic databases were searched. Single dose, double-blind, randomized, and controlled clinical trials comparing the analgesic effect of a selective COX-2 inhibitor versus at least one active control group using ibuprofen after impacted third molar removal were selected. RESULTS: Twelve studies were included for the qualitative synthesis and eight were included in the meta-analysis. No statistically significant differences were found between selective COX-2 inhibitors and ibuprofen in terms of pain relief after 6, 8, and 12 h. Rescue analgesia use after 24 h was significantly greater in the ibuprofen group than in the selective COX-2 inhibitor group. There were no statistically significant differences in the number of patients presenting one or more adverse events between the two groups, though ibuprofen intake was related with more nausea and vomiting. CONCLUSIONS: No statistically significant differences were found in terms of pain relief 6, 8, and 12 h post-medication between selective COX-2 inhibitors and ibuprofen following totally or partially impacted third molar removal. The patients who consumed selective COX-2 inhibitors needed less rescue analgesia after 24 h. The occurrence of one or more adverse events was similar in both groups, though patients who consumed ibuprofen had more nausea and vomiting. CLINICAL RELEVANCE: COX-2 inhibitors could be considered a suitable alternative to ibuprofen for pain relief after third molar extraction in patients at risk of developing nausea and vomiting. Also, COX-2 inhibitors seem to slightly reduce the need of rescue medication consumption. FAU - González-Barnadas, Albert AU - González-Barnadas A AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. FAU - Camps-Font, Octavi AU - Camps-Font O AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. FAU - Martín-Fatás, Pablo AU - Martín-Fatás P AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. FAU - Figueiredo, Rui AU - Figueiredo R AUID- ORCID: 0000-0002-2122-6530 AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. ruipfigueiredo@hotmail.com. AD - Facultad de Medicina y Ciencias de la Salud, Campus de Bellvitge, Universidad de Barcelona, C/ Feixa Llarga s/n, Pavelló Govern, 2ª planta, Despatx 2.9 08907 - L'Hospitalet de Llobregat, Barcelona, Spain. ruipfigueiredo@hotmail.com. FAU - Gay-Escoda, Cosme AU - Gay-Escoda C AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. AD - School of Dentistry, University of Barcelona, Barcelona, Spain. FAU - Valmaseda-Castellón, Eduard AU - Valmaseda-Castellón E AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20190423 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Analgesics) RN - 0 (Cyclooxygenase 2 Inhibitors) SB - D MH - Analgesics/*therapeutic use MH - Cyclooxygenase 2 Inhibitors/*therapeutic use MH - Double-Blind Method MH - Humans MH - *Molar, Third MH - Pain Management/*methods MH - Pain, Postoperative MH - *Randomized Controlled Trials as Topic MH - *Tooth Extraction OTO - NOTNLM OT - Analgesics OT - COX-2 inhibitors OT - Ibuprofen OT - Pain relief OT - Third molars EDAT- 2019/04/25 06:00 MHDA- 2020/02/07 06:00 CRDT- 2019/04/25 06:00 PHST- 2018/02/11 00:00 [received] PHST- 2019/04/09 00:00 [accepted] PHST- 2019/04/25 06:00 [pubmed] PHST- 2020/02/07 06:00 [medline] PHST- 2019/04/25 06:00 [entrez] AID - 10.1007/s00784-019-02910-3 [pii] AID - 10.1007/s00784-019-02910-3 [doi] PST - ppublish SO - Clin Oral Investig. 2020 Jan;24(1):79-96. doi: 10.1007/s00784-019-02910-3. Epub 2019 Apr 23. PMID- 31125538 OWN - NLM STAT- MEDLINE DCOM- 20200807 LR - 20200807 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 77 IP - 10 DP - 2019 Oct TI - Inferior Alveolar Nerve Block Using the Anterior Technique to Anesthetize Buccal Nerve and Improve Anesthesia Success Rates for Third Molar Extraction: A Randomized Controlled Trial and Magnetic Resonance Imaging Evaluation. PG - 2004-2016 LID - S0278-2391(19)30452-5 [pii] LID - 10.1016/j.joms.2019.04.021 [doi] AB - PURPOSE: The lack of anesthesia to the buccal nerve and an insufficient volume of anesthetic have been reported to be responsible for failed inferior alveolar nerve blocks (IANBs) using the Halsted approach (conventional IANB). We aimed to determine the extent of anesthesia in the buccal nerve innervation area and evaluate the anesthetic efficacy of injecting a larger volume of anesthetic during IANB using the anterior approach (anterior technique) in the clinical setting and with magnetic resonance imaging (MRI) analysis. PATIENTS AND METHODS: The prospective randomized controlled trial included patients scheduled for removal of a mandibular third molar. The primary predictor variables were the approach for IANB (anterior technique vs conventional IANB) and anesthetic dose (1.8 vs 2.7 mL). The primary outcome variables were the extent of anesthesia and the anesthesia success rate, defined as completion without additional anesthesia. The secondary outcome variable was the anesthetic drug distribution related to the pterygomandibular space measured on T2-weighted MRI scans. Statistical independence of the anesthesia success rate among the primary predictor variables was tested with statistical significance set at P ≤ .05. RESULTS: A total of 108 patients and 10 volunteers were enrolled in the clinical and MRI studies, respectively. Anesthesia of the buccal nerve was evident in patients receiving the anterior technique with 2.7 mL of anesthetic. The success rate of the anterior technique with 2.7 mL of anesthetic (96%) was greater than that with 1.8 mL of anesthetic (67%; P = .0113), and increasing the dose had no effect on the efficacy of conventional IANB (78% vs 81%; P = 1.000). The MRI study showed that the anesthetic was distributed over the anterior surface of the temporalis tendon and in the pterygomandibular space after the anterior technique. CONCLUSIONS: Anesthesia of the buccal nerve using the anterior technique with 2.7 mL of anesthetic solution might contribute to increasing the success rate of anesthesia for removal of mandibular third molars. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Tsukimoto, Shota AU - Tsukimoto S AD - Research Associate, Department of Anesthesiology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Takasugi, Yoshihiro AU - Takasugi Y AD - Assistant Professor, Department of Anesthesiology, Kindai University Faculty of Medicine, Osaka, Japan. Electronic address: dzc01654@nifty.com. FAU - Aoki, Risa AU - Aoki R AD - Research Associate, Department of Anesthesiology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Kimura, Motoshi AU - Kimura M AD - Assistant Professor, Department of Oral Surgery, Osaka Medical College, Osaka, Japan. FAU - Konishi, Tatsuo AU - Konishi T AD - Radiological Technologist, Department of Radiology, Kindai University Hospital, Osaka, Japan. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190425 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Local) SB - AIM SB - D SB - IM EIN - J Oral Maxillofac Surg. 2020 Jan;78(1):173. PMID: 31600489 MH - *Anesthesia, Dental MH - *Anesthetics, Local MH - Double-Blind Method MH - Humans MH - Magnetic Resonance Imaging MH - Mandibular Nerve MH - *Molar, Third MH - *Nerve Block MH - Prospective Studies MH - *Tooth Extraction EDAT- 2019/05/28 06:00 MHDA- 2020/08/08 06:00 CRDT- 2019/05/25 06:00 PHST- 2019/01/23 00:00 [received] PHST- 2019/04/17 00:00 [revised] PHST- 2019/04/17 00:00 [accepted] PHST- 2019/05/28 06:00 [pubmed] PHST- 2020/08/08 06:00 [medline] PHST- 2019/05/25 06:00 [entrez] AID - S0278-2391(19)30452-5 [pii] AID - 10.1016/j.joms.2019.04.021 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2019 Oct;77(10):2004-2016. doi: 10.1016/j.joms.2019.04.021. Epub 2019 Apr 25. PMID- 32577708 OWN - NLM STAT- MEDLINE DCOM- 20200812 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 51 IP - 8 DP - 2020 TI - Effect of audiovisual eyeglasses on intraoperative pain, anxiety, and hemodynamic changes during mandibular third molar extraction: a randomized controlled clinical trial. PG - 640-648 LID - 10.3290/j.qi.a44811 [doi] AB - OBJECTIVES: To determine the effect of audiovisual eyeglasses in terms of anxiety relief, hemodynamic changes, and intraoperative pain in patients undergoing surgical removal of a mandibular third molar. METHOD AND MATERIALS: A randomized controlled clinical trial with two parallel groups was carried out in patients undergoing mandibular third molar extraction. Fifteen patients watched a video with multimedia eyeglasses during the surgical procedure, whereas 15 controls had their eyes covered during extraction. The patients completed anxiety questionnaires before and after surgery. Hemodynamic changes, intraoperative pain, duration of the surgery, and overall satisfaction were recorded. RESULTS: Thirty patients were analyzed. Intraoperative pain and the need for supplemental anesthesia were significantly more frequent in the control group (53.3% versus 13.3%; P < .05). The surgical procedure was also briefer when the eyeglasses were used (17.2 versus 28.1 minutes). Overall satisfaction was similar in both groups. No significant differences were found between the two study groups in terms of anxiety and hemodynamic parameters. CONCLUSIONS: The use audiovisual eyeglasses should be routinely considered during mandibular third molar extraction since these devices allow reduction of intraoperative pain and surgery time. However, patient anxiety level and hemodynamic parameters seem to remain unaltered. FAU - Luque-Ribas, Marta AU - Luque-Ribas M FAU - Figueiredo, Rui AU - Figueiredo R FAU - Guerra-Pereira, Inês AU - Guerra-Pereira I FAU - Valmaseda-Castellón, Eduard AU - Valmaseda-Castellón E LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Anxiety MH - Eyeglasses MH - Hemodynamics MH - Humans MH - Molar, Third MH - Pain, Postoperative MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - anxiety OT - audiovisual eyeglasses OT - hemodynamic changes OT - intraoperative pain OT - multimedia eyeglasses OT - surgical procedure OT - third molar EDAT- 2020/06/25 06:00 MHDA- 2020/08/13 06:00 CRDT- 2020/06/25 06:00 PHST- 2020/06/25 06:00 [pubmed] PHST- 2020/08/13 06:00 [medline] PHST- 2020/06/25 06:00 [entrez] AID - 841337 [pii] AID - 10.3290/j.qi.a44811 [doi] PST - ppublish SO - Quintessence Int. 2020;51(8):640-648. doi: 10.3290/j.qi.a44811. PMID- 30853212 OWN - NLM STAT- MEDLINE DCOM- 20191029 LR - 20191031 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 48 IP - 10 DP - 2019 Oct TI - Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial. PG - 1348-1354 LID - S0901-5027(19)30070-0 [pii] LID - 10.1016/j.ijom.2019.02.006 [doi] AB - The objective of this study was to compare the efficacy of celecoxib and ibuprofen in reducing postoperative sequelae following the surgical removal of impacted mandibular third molars. Ninety-eight subjects who needed surgical extraction of an impacted mandibular third molar were selected for the study. All subjects were randomly allocated to receive one of the following treatments twice a day for 5days after surgery: placebo (n=32), ibuprofen (n=33), or celecoxib (n=33). The primary outcome chosen was postoperative pain, which was evaluated using the visual analogue scale (VAS) score recorded by each patient. The secondary outcomes chosen were changes in postoperative swelling and maximum mouth opening values compared to preoperative ones. Compared to placebo, treatment with celecoxib and ibuprofen resulted in improvements in the primary outcome. Furthermore, when compared to the other groups, patients in the celecoxib group showed a significant reduction in postoperative pain scores at 6h (P<0.001), 12h (P=0.011), and 24h (P=0.041) after surgery. Regarding swelling and maximum mouth opening values, there were no significant differences between the groups at each follow-up session. This study demonstrated that treatment with celecoxib decreased the incidence and severity of postoperative pain following third molar surgery compared to ibuprofen and placebo. CI - Copyright © 2019 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Isola, G AU - Isola G AD - Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Catania, Italy; Department of Biomedical and Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, Messina, Italy. Electronic address: gaetano.isola@unict.it. FAU - Matarese, M AU - Matarese M AD - Department of Biomedical and Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, Messina, Italy. FAU - Ramaglia, L AU - Ramaglia L AD - Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Naples, Italy. FAU - Cicciù, M AU - Cicciù M AD - Department of Biomedical and Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, Messina, Italy. FAU - Matarese, G AU - Matarese G AD - Department of Biomedical and Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, Messina, Italy. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190308 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - JCX84Q7J1L (Celecoxib) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM CIN - Int J Oral Maxillofac Surg. 2019 Dec;48(12):1608. PMID: 31230772 CIN - Int J Oral Maxillofac Surg. 2019 Dec;48(12):1608-1609. PMID: 31230774 MH - Celecoxib MH - Double-Blind Method MH - Humans MH - *Ibuprofen MH - Molar, Third MH - Pain, Postoperative MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - celecoxib OT - ibuprofen OT - pain OT - randomized clinical trial OT - swelling OT - third molar surgery OT - trismus EDAT- 2019/03/12 06:00 MHDA- 2019/10/30 06:00 CRDT- 2019/03/12 06:00 PHST- 2018/06/28 00:00 [received] PHST- 2018/12/12 00:00 [revised] PHST- 2019/02/12 00:00 [accepted] PHST- 2019/03/12 06:00 [pubmed] PHST- 2019/10/30 06:00 [medline] PHST- 2019/03/12 06:00 [entrez] AID - S0901-5027(19)30070-0 [pii] AID - 10.1016/j.ijom.2019.02.006 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2019 Oct;48(10):1348-1354. doi: 10.1016/j.ijom.2019.02.006. Epub 2019 Mar 8. PMID- 33475533 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 0030-9982 (Print) IS - 0030-9982 (Linking) VI - 70 IP - 12(B) DP - 2020 Dec TI - Effects of different polyvinylpyrrolidone iodine concentrations on trismus and swelling following third molar surgery. PG - 2304-2309 LID - 10.5455/JPMA.130 [doi] AB - OBJECTIVE: To compare the clinical efficacy of different povidone iodine concentrations for the management of postoperative pain and swelling following mandibular third molar surgery. METHODS: The randomised, prospective, double-blind and controlled study was conducted from October 2016 to January 2018 at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Biruni University, Istanbul, Turkey, and comprised individuals aged 18-30 years who underwent surgical removal of pathology-free completely unerrupted mandibular lower third molars. The participants were randomly assigned to four groups: Group I had saline-only controls, Group II was given 0.5% concentration of povidone iodine, Group III had 1% concentration of povidone iodine, and Group IV had 3% concentration of povidone iodine. Facial swelling and trismus were assessed on the 2nd and 7th postoperative days. Data was analysed using SPSS 22. RESULTS: Of the 80 patients, 34(42.5%) were males and 46 (57.5%) were females with an overall mean age of 24.6±3.68 years. Each group had 20 (25%) subjects. All three concentrations of povidone iodine provided significant reduction in postoperative trismus compared to the controls. Trismus was less in Group III and Group IV compared to Group II up to 7 days after surgery. CONCLUSIONS: Irrigation with 3% povidone iodine concentration was found to be more effective in reducing the level of facial swelling after impacted third molar surgery. (Clinical Trials.gov Identifier: NCT03894722). FAU - Yuce, Esra AU - Yuce E AD - Department of Oral and Maxillofacial Surgery, Istanbul Aydin University, Istanbul,Turkey. FAU - Dereci, Omur AU - Dereci O AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Eskisehir Osmangazi University, Eskisehir, Turkey. FAU - Altin, Nazli AU - Altin N AD - Department of Oral and Maxillofacial Surgery, Gungoren Oral And Dental Health Center, Istanbul, Turkey. FAU - Koca, Cansugul Efeoglu AU - Koca CE AD - Department of Oral and Maxillofacial Surgery, Usak University, Usak, Turkey. FAU - Yazan, Murude AU - Yazan M AD - Department of Oral and Maxillofacial Surgery, Biruni University, Istanbul,Turkey. LA - eng SI - ClinicalTrials.gov/NCT03894722 PT - Journal Article PT - Randomized Controlled Trial PL - Pakistan TA - J Pak Med Assoc JT - JPMA. The Journal of the Pakistan Medical Association JID - 7501162 RN - 85H0HZU99M (Povidone-Iodine) SB - IM MH - Adolescent MH - Adult MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - *Povidone-Iodine/therapeutic use MH - Prospective Studies MH - Tooth Extraction/adverse effects MH - *Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control MH - Turkey MH - Young Adult OTO - NOTNLM OT - Maxillofacial surgery, Third molar, Povidone-Iodine, Swelling, Tismus EDAT- 2021/01/22 06:00 MHDA- 2021/05/15 06:00 CRDT- 2021/01/21 12:16 PHST- 2021/01/21 12:16 [entrez] PHST- 2021/01/22 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] AID - 10295 [pii] AID - 10.5455/JPMA.130 [doi] PST - ppublish SO - J Pak Med Assoc. 2020 Dec;70(12(B)):2304-2309. doi: 10.5455/JPMA.130. PMID- 31050816 OWN - NLM STAT- MEDLINE DCOM- 20191126 LR - 20191126 IS - 1365-2842 (Electronic) IS - 0305-182X (Linking) VI - 46 IP - 9 DP - 2019 Sep TI - The influence of flap design on sequelae and quality of life following surgical removal of impacted mandibular third molars: A split-mouth randomised clinical trial. PG - 828-835 LID - 10.1111/joor.12814 [doi] AB - BACKGROUND: Surgical removal of impacted mandibular third molar is one of the most frequently performed interventions in oral and maxillofacial surgery. OBJECTIVES: To compare two different flap designs in terms of sequelae and quality of life following surgical removal of impacted third molars. METHODS: This prospective, randomised, split-mouth clinical study involved patients referred for surgical removal of bilateral symmetrical impacted mandibular third molars. Envelope flap and modified triangular flap techniques were used. The effects of flap design on trismus, swelling, wound dehiscence, alveolar osteitis, haematoma, infection and quality of life were evaluated on post-operative days 3 and 7. Pain levels were assessed on post-operative days 1, 3 and 7. RESULTS: Significant differences were determined between the two groups in terms of trismus, pain and wound dehiscence scores on post-operative day 3. However, on post-operative day 7, this difference was observed only in trismus. Statistically significant differences were also determined between the two groups on post-operative day 3 for social isolation and eating subscale scores as well as total quality of life score. CONCLUSION: Based on the study findings, the modified triangular flap may be superior to the envelope flap in terms of pain, trismus, and wound dehiscence in the first 3 days after impacted third molar surgery and may have a better impact on quality of life during this process. CI - © 2019 John Wiley & Sons Ltd. FAU - Şimşek Kaya, Göksel AU - Şimşek Kaya G AUID- ORCID: 0000-0003-3398-5574 AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Akdeniz University, Antalya, Turkey. FAU - Yapıcı Yavuz, Günay AU - Yapıcı Yavuz G AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adıyaman University, Adıyaman, Turkey. FAU - Saruhan, Nesrin AU - Saruhan N AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Eskişehir Osmangazi University, Eskişehir, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190514 PL - England TA - J Oral Rehabil JT - Journal of oral rehabilitation JID - 0433604 SB - D SB - IM MH - Humans MH - *Molar, Third MH - Pain, Postoperative MH - Prospective Studies MH - Quality of Life MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - envelope flap OT - impacted third molar OT - modified triangular flap OT - quality of life OT - sequela OT - third molar surgery EDAT- 2019/05/06 06:00 MHDA- 2019/11/27 06:00 CRDT- 2019/05/04 06:00 PHST- 2018/10/11 00:00 [received] PHST- 2019/04/15 00:00 [revised] PHST- 2019/04/27 00:00 [accepted] PHST- 2019/05/06 06:00 [pubmed] PHST- 2019/11/27 06:00 [medline] PHST- 2019/05/04 06:00 [entrez] AID - 10.1111/joor.12814 [doi] PST - ppublish SO - J Oral Rehabil. 2019 Sep;46(9):828-835. doi: 10.1111/joor.12814. Epub 2019 May 14. PMID- 26374745 OWN - NLM STAT- MEDLINE DCOM- 20171013 LR - 20181113 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 20 IP - 5 DP - 2016 Jun TI - TETIS study: evaluation of new topical hemostatic agent TT-173 in tooth extraction. PG - 1055-63 LID - 10.1007/s00784-015-1586-1 [doi] AB - OBJECTIVES: TT-173 is a new hemostatic agent consisting of yeast-derived microvesicles containing a modified version of recombinant human tissue factor. In the present work, the procoagulant activity of TT-173 has been evaluated for the first time in humans. METHODS: This is a phase I, randomized, placebo-controlled study to evaluate the efficacy, safety, systemic absorption, and immunogenicity of TT-173 in healthy volunteers undergoing tooth extraction. Subjects received TT-173 or placebo into the alveolar cavity, just after tooth extraction. Time to clot formation, bleeding time, and adverse events were recorded. RESULTS: Treatment with TT-173 reduced the bleeding time and the time to clot formation. No adverse events related with product administration were reported. In the same way, neither systemic absorption nor immunogenic reaction against the product was detected. Our findings pave the way to evaluate the usefulness of this new topical hemostatic agent in more complex oral surgeries and in those patients affected with coagulation disorders that may compromise the realization of dental procedures. CONCLUSION: The new hemostatic agent TT-173 has proven efficacious and safe in healthy subjects undergoing tooth extraction supporting its further evaluation in more complex surgeries. CLINICAL RELEVANCE: The development of this new topical hemostatic agent could contribute to bleeding control in oral and maxillofacial surgery. FAU - López-López, José AU - López-López J AD - Department of Odontostomatology, School of Dentistry-Hospital Odontológico Universidad de Barcelona, Barcelona University, C/Feixa Llarga s/n, 08907, Hospitalet de Llobregat, Barcelona, Spain. 18575jll@gmail.com. FAU - Jané-Salas, Enric AU - Jané-Salas E AD - Department of Odontostomatology, School of Dentistry-Hospital Odontológico Universidad de Barcelona, Barcelona University, C/Feixa Llarga s/n, 08907, Hospitalet de Llobregat, Barcelona, Spain. FAU - Santamaría, Amparo AU - Santamaría A AD - Hemostasia and Thrombosis Unit, Department of Hematology, Hospital Universitari Vall d'Hebrón, Barcelona, Spain. FAU - González-Navarro, Beatriz AU - González-Navarro B AD - Department of Odontostomatology, School of Dentistry-Hospital Odontológico Universidad de Barcelona, Barcelona University, C/Feixa Llarga s/n, 08907, Hospitalet de Llobregat, Barcelona, Spain. FAU - Arranz-Obispo, Carlos AU - Arranz-Obispo C AD - Department of Odontostomatology, School of Dentistry-Hospital Odontológico Universidad de Barcelona, Barcelona University, C/Feixa Llarga s/n, 08907, Hospitalet de Llobregat, Barcelona, Spain. FAU - López, Ramón AU - López R AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Miquel, Ignasi AU - Miquel I AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Arias, Belén AU - Arias B AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Sánchez, Pilar AU - Sánchez P AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Rincón, Esther AU - Rincón E AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Rodríguez, Juan R AU - Rodríguez JR AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Rojas, Santiago AU - Rojas S AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. FAU - Murat, Jesus AU - Murat J AD - S.L. Parque Mediterráneo de la Tecnología, Thombotargets Europe, Castelldefels, Spain. LA - eng PT - Clinical Trial, Phase I PT - Journal Article PT - Randomized Controlled Trial DEP - 20150915 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Hemostatics) RN - 9035-58-9 (Thromboplastin) SB - D MH - Administration, Topical MH - Adult MH - Female MH - Hemostatics/administration & dosage/*pharmacology MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/*prevention & control MH - Prospective Studies MH - Single-Blind Method MH - Thromboplastin/administration & dosage/*pharmacology MH - *Tooth Extraction MH - Treatment Outcome OTO - NOTNLM OT - Surgical bleeding OT - TT-173 OT - Thrombin OT - Tissue factor OT - Tooth extraction OT - Topical hemostatic EDAT- 2015/09/17 06:00 MHDA- 2017/10/14 06:00 CRDT- 2015/09/17 06:00 PHST- 2014/11/18 00:00 [received] PHST- 2015/08/30 00:00 [accepted] PHST- 2015/09/17 06:00 [entrez] PHST- 2015/09/17 06:00 [pubmed] PHST- 2017/10/14 06:00 [medline] AID - 10.1007/s00784-015-1586-1 [pii] AID - 10.1007/s00784-015-1586-1 [doi] PST - ppublish SO - Clin Oral Investig. 2016 Jun;20(5):1055-63. doi: 10.1007/s00784-015-1586-1. Epub 2015 Sep 15. PMID- 32725573 OWN - NLM STAT- MEDLINE DCOM- 20210215 LR - 20210215 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 25 IP - 1 DP - 2021 Mar TI - Analgesia and side effects of codeine phosphate associated with paracetamol vs. paracetamol after the extraction of mandibular third molars: a randomized double-blind clinical trial using the split-mouth model. PG - 49-53 LID - 10.1007/s10006-020-00888-x [doi] AB - PURPOSE: To assess the analgesia and side effects of codeine phosphate associated with paracetamol (test medication) as compared to paracetamol (control medication) after the extraction of impacted mandibular third molars. MATERIALS AND METHODS: Forty-seven patients removed the right and left impacted mandibular third molars. After one surgery, patients took the test medication and after the other surgery, they took the control medication. Patients with exacerbated pain were prescribed to use the rescue medication instead of the medication initially administered and were included in the rescue group. They were evaluated for 7 days postoperatively, and the mean score of the visual analogue scale (VAS) of pain between test and control medications was assessed by the Poisson distribution. The side effects of these medications were assessed by the patient's complaints. A P value of < .05 was considered to be statistically significant. RESULTS: The mean score of the VAS of pain was not statistically different between test and control medications in the non-rescue group, but it was significantly greater in patients previously using paracetamol in the rescue group. The most common side effects reported in both groups, predominantly in patients using the test medication, were drowsiness, dizziness, and nausea. CONCLUSION: The use of codeine phosphate associated with paracetamol after the extraction of impacted mandibular third molars is a better choice to control the postoperative pain rather than paracetamol, but with more side effects, which are clinically acceptable. FAU - Furtado de Carvalho, Matheus AU - Furtado de Carvalho M AD - Department of Maxillofacial Surgery, Federal University of Juiz de Fora, Juiz de Fora, Brazil. FAU - Slusarenko da Silva, Yuri AU - Slusarenko da Silva Y AUID- ORCID: 0000-0002-8307-9134 AD - School of Dentistry, UniFG University Center (Faculty of Guanambi), Avenida Pedro Felipe Duarte 4911 São Sebastião, Guanambi, Bahia, 46430-000, Brazil. yu.slu@hotmail.com. FAU - Reher, Peter AU - Reher P AD - School of Dentistry and Oral Health, Griffith University, Griffith, Australia. FAU - Naclério-Homem, Maria da Graça AU - Naclério-Homem MDG AD - Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, Faculty of Dentistry, University of São Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200728 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Acetaminophen MH - *Analgesia MH - Codeine/adverse effects MH - Double-Blind Method MH - Humans MH - Molar, Third/surgery MH - Pain, Postoperative/drug therapy/etiology MH - Tooth Extraction MH - *Tooth, Impacted/surgery OTO - NOTNLM OT - Codeine phosphate OT - Molar, third OT - Pain, postoperative OT - Paracetamol OT - Tooth extraction EDAT- 2020/07/30 06:00 MHDA- 2021/02/16 06:00 CRDT- 2020/07/30 06:00 PHST- 2020/04/14 00:00 [received] PHST- 2020/07/22 00:00 [accepted] PHST- 2020/07/30 06:00 [pubmed] PHST- 2021/02/16 06:00 [medline] PHST- 2020/07/30 06:00 [entrez] AID - 10.1007/s10006-020-00888-x [pii] AID - 10.1007/s10006-020-00888-x [doi] PST - ppublish SO - Oral Maxillofac Surg. 2021 Mar;25(1):49-53. doi: 10.1007/s10006-020-00888-x. Epub 2020 Jul 28. PMID- 31336212 OWN - NLM STAT- MEDLINE DCOM- 20200924 LR - 20200924 IS - 2468-7855 (Electronic) IS - 2468-7855 (Linking) VI - 121 IP - 3 DP - 2020 Jun TI - Comparison of latency and efficacy of twin mix and modified twin mix in impacted mandibular third molar surgery - A Preliminary Randomized Triple Blind Split Mouth Clinical Study. PG - 248-253 LID - S2468-7855(19)30176-4 [pii] LID - 10.1016/j.jormas.2019.07.011 [doi] AB - INTRODUCTION: Intra-space drug administration have recently gained popularity in the clinical practice posing several advantages over the conventional routes of drug administration. A preliminary prospective randomized triple blind clinical study was conducted to compare the latency and duration of anesthesia with twin mix (1.8ml 2% lignocaine with 1:200,000 epinephrine and 1ml/4mg dexamethasone) and modified twin mix (1.7ml of 4% articaine with 1:100,000 epinephrine and 1ml/4mg dexamethasone) to two conventional local anesthesia solutions along with co-relation of clinical effects in the postoperative phase in patients undergoing extraction of impacted mandibular third molars in terms of patients comfort post-surgery. MATERIALS AND METHODS: The study was conducted among 20 patients with bilateral impacted mandibular third molars who were randomly allotted to two groups, Group A and B. Each patients in both the groups was allotted with study and control site. Among Group A, patients were further divided into Sub-group L (Control) and Sub-group TM (Twin Mix). Group B patients were divided as Sub-group A (Control) and sub-group MTM (Modified Twin Mix). Sub-group L patients received 1.8ml of 2% lignocaine with 1:200,000 adrenaline and sub-group TM received twin mix. Sub-group A received 1.7ml of 4% articaine with 1:100,000 adrenaline and sub-group MTM received modified twin mix solution. All the procedure was performed by a single operator with a gap of 1 month between the two interventions among both the groups. Various subjective and objective parameters were measured pre-operatively and postoperatively to assess the latency and efficacy of various anesthesia solutions used in this study for third molar removal. RESULTS: Mean (±SD) VAS scores for sting on injection and pain were found to be less in TM and MTM sub-group with a score of 2.3 (±0.768) and 2.7 (±0.065) respectively. The anesthetic latency was significantly less in sub-group TM, with a mean (±SD) of 52.4 (±28.3) seconds. Sub-groups A and MTM had longer latency of anesthesia when compared with L and TM sub-groups. The duration of soft tissue anesthesia was maximum in sub-group MTM as compared to the other sub-groups. Patients from control sub-groups among both the groups had increased swelling, post-surgical pain and trismus postoperatively. DISCUSSION: Intra-space administration of twin mix and modified twin mix is clinically efficacious in impacted mandibular third molars surgery with better clinical outcomes postoperatively. We observed one significant difference between TM and MTM that the latter solution provided a prolonged duration of anesthesia increasing the patient's comfort postoperatively after surgical removal of mandibular third molars. CI - Copyright © 2019 Elsevier Masson SAS. All rights reserved. FAU - Beena, S AU - Beena S AD - Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, People's University, H-3/2, B.D.A Colony, Nayapura, Lal Ghati, Airport Road, 462037 Bhanpur, Bhopal, MP, India. FAU - Bhargava, D AU - Bhargava D AD - Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, People's University, H-3/2, B.D.A Colony, Nayapura, Lal Ghati, Airport Road, 462037 Bhanpur, Bhopal, MP, India. Electronic address: emaildarpan@gmail.com. FAU - Gurjar, P AU - Gurjar P AD - Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, People's University, H-3/2, B.D.A Colony, Nayapura, Lal Ghati, Airport Road, 462037 Bhanpur, Bhopal, MP, India. FAU - Shrivastava, S AU - Shrivastava S AD - Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, People's University, H-3/2, B.D.A Colony, Nayapura, Lal Ghati, Airport Road, 462037 Bhanpur, Bhopal, MP, India. FAU - Dalsingh, V AU - Dalsingh V AD - Head, Department of Oral and Maxillofacial Surgery, Lenora Institute of Dental Sciences, 533294 Rajahmundry, AP, India. FAU - Koneru, G AU - Koneru G AD - Sibar Institute of Dental Sciences and Research Center, Department of Oral and Maxillofacial Surgery, 522509 Vijayawada, AP, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190720 PL - France TA - J Stomatol Oral Maxillofac Surg JT - Journal of stomatology, oral and maxillofacial surgery JID - 101701089 SB - D SB - IM MH - Double-Blind Method MH - Humans MH - Molar, Third/*surgery MH - Prospective Studies MH - Tooth Extraction MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - Dexamethasone OT - Dexamethasonized Local anesthesia OT - Lidocaine OT - Local Anesthesia OT - Pain OT - Third molar OT - Twin Mix EDAT- 2019/07/25 06:00 MHDA- 2020/09/25 06:00 CRDT- 2019/07/24 06:00 PHST- 2019/01/30 00:00 [received] PHST- 2019/07/11 00:00 [revised] PHST- 2019/07/12 00:00 [accepted] PHST- 2019/07/25 06:00 [pubmed] PHST- 2020/09/25 06:00 [medline] PHST- 2019/07/24 06:00 [entrez] AID - S2468-7855(19)30176-4 [pii] AID - 10.1016/j.jormas.2019.07.011 [doi] PST - ppublish SO - J Stomatol Oral Maxillofac Surg. 2020 Jun;121(3):248-253. doi: 10.1016/j.jormas.2019.07.011. Epub 2019 Jul 20. PMID- 31344339 OWN - NLM STAT- MEDLINE DCOM- 20200810 LR - 20200810 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 77 IP - 12 DP - 2019 Dec TI - Alveolar Iodine Tampon Packing Reduces Postoperative Morbidity After Third Molar Surgery. PG - 2401-2411 LID - S0278-2391(19)30806-7 [pii] LID - 10.1016/j.joms.2019.06.175 [doi] AB - PURPOSE: The aim of this study was to assess the efficacy of an iodine tampon after mandibular third molar surgery on oral health-related quality of life (OHRQoL), use of painkillers, postoperative sequelae, and self-care behaviors in the first postoperative week. MATERIALS AND METHODS: This prospective, crossover, randomized controlled study included patients undergoing surgical removal of bilateral symmetrically, horizontally impacted mandibular third molars. The surgical site was randomly allocated to receive an iodine tampon after surgery or wound closure and rinsing with a Monoject syringe (Tyco/Healthcare-Kendall, Mansfield, MA). The primary outcomes measured each day during the first postoperative week were the Oral Health Impact Profile 14 score and postoperative sequelae, including pain, swelling, limited mouth opening, postoperative infection, and alveolar osteitis. The secondary outcome measures were several self-care behaviors. Data were analyzed using repeated-measures analysis of variance and paired-samples t tests. RESULTS: A total of 54 patients (25 men and 29 women; mean age, 25.1 years) were enrolled, with a total of 108 surgically removed impacted mandibular third molars. The use of an iodine tampon resulted in a significantly lower impact on OHRQoL (mean of 21.5 [standard deviation (SD), 9.6] vs 26.5 [SD, 10.6]) on the first postoperative day, which was observable until the seventh postoperative day. In addition, after removal of the impacted third molar, patients with the iodine tampon condition reported less pain (mean of 5.2 [SD, 1.9] vs 6.1 [SD, 2.1] on day 1, lasting throughout the week), less use of painkillers, less limited mouth opening, fewer problems chewing, less swelling, and earlier recovery. CONCLUSIONS: The use of postoperative iodine packing after the removal of impacted mandibular third molars significantly reduces OHRQoL and postoperative sequelae. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Tuk, Jacco G AU - Tuk JG AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, and Private Practice, Amstelland Hospital, Amstelveen, The Netherlands. FAU - Lindeboom, Jerome A AU - Lindeboom JA AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, and Private Practice, Amstelland Hospital, Amstelveen, The Netherlands. Electronic address: j.a.lindeboom@amc.uva.nl. FAU - Sana, Faro AU - Sana F AD - Dental Student, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, The Netherlands. FAU - van Wijk, Arjen J AU - van Wijk AJ AD - Associate Professor, Department of Social Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam, and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Milstein, Dan M J AU - Milstein DMJ AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, The Netherlands. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190701 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 9679TC07X4 (Iodine) SB - AIM SB - D SB - IM MH - Adult MH - Edema MH - Female MH - Humans MH - *Iodine MH - Male MH - Mandible MH - Molar, Third/surgery MH - Pain, Postoperative MH - *Postoperative Complications/prevention & control MH - Prospective Studies MH - Quality of Life MH - *Tooth Extraction MH - *Tooth, Impacted/surgery EDAT- 2019/07/26 06:00 MHDA- 2020/08/11 06:00 CRDT- 2019/07/26 06:00 PHST- 2018/11/17 00:00 [received] PHST- 2019/06/08 00:00 [revised] PHST- 2019/06/17 00:00 [accepted] PHST- 2019/07/26 06:00 [pubmed] PHST- 2020/08/11 06:00 [medline] PHST- 2019/07/26 06:00 [entrez] AID - S0278-2391(19)30806-7 [pii] AID - 10.1016/j.joms.2019.06.175 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2019 Dec;77(12):2401-2411. doi: 10.1016/j.joms.2019.06.175. Epub 2019 Jul 1. PMID- 31589558 OWN - NLM STAT- MEDLINE DCOM- 20200630 LR - 20200630 IS - 2578-5478 (Electronic) IS - 2578-5478 (Linking) VI - 37 IP - 11 DP - 2019 Nov TI - Can Photobiomodulation Therapy Be an Alternative to Methylprednisolone in Reducing Pain, Swelling, and Trismus After Removal of Impacted Third Molars? PG - 700-705 LID - 10.1089/photob.2019.4696 [doi] AB - Background and objective: Studies investigating an alternative to corticosteroids in terms of potential side effects after surgical removal of impacted third molars are still ongoing. Accordingly, the present randomized single-blind study aimed to compare the efficacy of photobiomodulation therapy (PBMT) and methylprednisolone on pain, edema, and trismus after surgical removal of impacted third molars. Methods: The study included 30 healthy patients with bilaterally impacted lower third molars. The side (right or left molar) that would be extracted at first and the treatment (PBMT or corticosteroid) that would be applied to this side were decided by tossing a coin. The time interval between two surgical operations was at least 3 weeks. In the laser group, immediately after the surgical procedure, PBMT was applied extraorally to the insertion point of the masseter muscle for 60 sec with an output power of 0.3 W and an energy density of 6 J/cm(2) and then repeated on postoperative days 1 and 2. In the corticosteroid group, 40 mg/2 mL methylprednisolone sodium succinate was injected postoperatively into the masseter muscle with the intrabuccal approach. On postoperative day 1, methylprednisolone injection (20 mg/1 mL) was repeated. Pain was evaluated using the visual analog scale on postoperative days 1, 2, and 7. Edema (in mm) and trismus (in mm) were evaluated preoperatively and on postoperative days 2 and 7. Results: There were no significant differences between the PBMT and methylprednisolone administration in terms of postoperative pain, edema, and trismus. Conclusions: Within the limits of the present study, PBMT was considered an alternative and a useful method for controlling inflammatory complications following impacted wisdom tooth surgery as it exhibited similar clinical efficacy to that of methylprednisolone. FAU - Feslihan, Erkan AU - Feslihan E AD - Tekirdag Oral and Dental Health Hospital, Tekirdag, Turkey. FAU - Eroğlu, Cennet Neslihan AU - Eroğlu CN AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Akdeniz University, Antalya, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20191007 PL - United States TA - Photobiomodul Photomed Laser Surg JT - Photobiomodulation, photomedicine, and laser surgery JID - 101734781 RN - 0 (Glucocorticoids) RN - 5GMR90S4KN (Methylprednisolone Hemisuccinate) SB - IM MH - Adolescent MH - Adult MH - Edema/prevention & control MH - Female MH - Glucocorticoids/therapeutic use MH - Humans MH - Lasers, Semiconductor MH - *Low-Level Light Therapy MH - Male MH - Methylprednisolone Hemisuccinate/*therapeutic use MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications/prevention & control MH - Single-Blind Method MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Visual Analog Scale MH - Young Adult OTO - NOTNLM OT - corticosteroid OT - methylprednisolone OT - pain OT - photobiomodulation therapy OT - swelling OT - trismus EDAT- 2019/10/08 06:00 MHDA- 2020/07/01 06:00 CRDT- 2019/10/08 06:00 PHST- 2019/10/08 06:00 [pubmed] PHST- 2020/07/01 06:00 [medline] PHST- 2019/10/08 06:00 [entrez] AID - 10.1089/photob.2019.4696 [doi] PST - ppublish SO - Photobiomodul Photomed Laser Surg. 2019 Nov;37(11):700-705. doi: 10.1089/photob.2019.4696. Epub 2019 Oct 7. PMID- 27192639 OWN - NLM STAT- MEDLINE DCOM- 20170612 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 27 IP - 4 DP - 2016 Jun TI - Does Simultaneous Third Molar Extraction Increase Intraoperative and Perioperative Complications in Orthognathic Surgery? PG - 923-6 LID - 10.1097/SCS.0000000000002648 [doi] AB - BACKGROUND: Prior to orthognathic surgery, most surgeons recommend third molar extraction. Espoused reasons include potential risk for infection, untoward osteotomies, and worsened postoperative discomfort. However, in addition to being another procedure for the patient, this may necessitate a longer preorthognathic surgery phase. The purpose of this study is to compare the outcomes of orthognathic surgery with staged versus simultaneous third molar extractions. METHODS: This was a retrospective analysis of patients who underwent orthognathic surgery from 2013 to 2014, with at least a 1-year follow-up period. Patients were stratified into 2 groups: Extraction of third molars at the time of surgery and prior extraction of third molars. Primary outcomes included the occurrence of unfavorable splits, infection, bleeding, malocclusion, and hardware failure. Secondary outcomes were procedure time, postoperative pain, and length of stay. Pearson χ tests and 2-tailed unpaired t tests were performed to determine if there was an association between the simultaneous removal of third molars and the primary and secondary outcome measures, respectively. RESULTS: One hundred patients were included in the study. Forty-nine patients had third molars extracted at the time of surgery and fifty-one did not. Complications included unfavorable split, postoperative infection, mild postoperative bleeding, postoperative malocclusion, and hardware failure. There was no significant difference in the incidence of complications in both groups. Procedure time was not considerably increased with extractions. There was no significant difference in postoperative pain or length of stay between both groups. CONCLUSIONS: Removing third molars concurrently with orthognathic surgery does not increase the risk of adverse outcomes, nor does it significantly influence hospital course. FAU - Steinbacher, Derek M AU - Steinbacher DM AD - *Department of Dentistry and Oral and Maxillofacial Surgery †Yale New Haven Hospital, New Haven, CT. FAU - Kontaxis, Katrina L AU - Kontaxis KL LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - D MH - Adolescent MH - Adult MH - Cohort Studies MH - Combined Modality Therapy MH - Female MH - Follow-Up Studies MH - Humans MH - Intraoperative Complications/*etiology MH - Male MH - Molar, Third/*surgery MH - *Orthognathic Surgery MH - Postoperative Complications/*etiology MH - Retrospective Studies MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2016/05/19 06:00 MHDA- 2017/06/13 06:00 CRDT- 2016/05/19 06:00 PHST- 2016/05/19 06:00 [entrez] PHST- 2016/05/19 06:00 [pubmed] PHST- 2017/06/13 06:00 [medline] AID - 10.1097/SCS.0000000000002648 [doi] PST - ppublish SO - J Craniofac Surg. 2016 Jun;27(4):923-6. doi: 10.1097/SCS.0000000000002648. PMID- 31116189 OWN - NLM STAT- MEDLINE DCOM- 20191029 LR - 20210227 IS - 2631-6439 (Electronic) IS - 2631-6420 (Linking) VI - 12 IP - 1 DP - 2019 TI - Dental extractions for patients on oral antiplatelet: a within-person randomised controlled trial comparing haemostatic plugs, advanced-platelet-rich fibrin (A-PRF+) plugs, leukocyte- and platelet-rich fibrin (L-PRF) plugs and suturing alone. PG - 77-87 AB - PURPOSE: To compare the outcome of tooth extractions in patients taking oral antithrombotic without reducing their dose. Four different interventions were compared within the same patient: suturing alone (control group), suturing plus a haemostatic plug, suturing plus advanced-platelet-rich fibrin (A-PRF+) plug, and suturing plus leukocyte- and platelet-rich fibrin (L-PRF) plug into the socket. MATERIALS AND METHODS: Forty patients, taking oral antiplatelet agents, requiring the extraction of at least four non-adjacent teeth were selected for the study. After extractions the sockets were randomly allocated to suturing alone (control group), suturing plus haemostatic plug (HAEM), suturing plus advanced-platelet-rich fibrin (A-PRF+) plug, and suturing plus leukocyte- and platelet-rich fibrin (L-PRF) plug into the socket without reducing the dose of oral antiplatelets according to a split-mouth design. Outcome measures were complications, time to complete each procedure, postoperative bleeding, costs of the materials, patient preference and a wound healing index recorded 1 and 2 weeks postextraction by blinded assessors. RESULTS: Two weeks after extraction no patient dropped out and no complication was reported. The average time to complete suturing after tooth extractions was: 1.0 ± 0.00 minutes at control sites, 1.5 ± 0.41 at HAEM sites, 2.8 ± 0.61 at A-PRF+ sites, and 2.8 ± 0.56 at L-PRF sites, the difference being statistically significant between each pairwise comparison except A-PRF+ vs L-PRF. Postoperative bleeding 30 minutes after extractions was present at 8, 5, 1 and 2 sites for control, HAEM, A-PRF+ and L-PRF sites, respectively. A-PRF showed statistically significantly less bleeding compared to the control group (odds ratio = 0.1 (95% CI [0.01;0.86]; P < 0.0361). In all cases bleeding was moderate in nature and not severe. One week after extractions the mean wound healing index was 1.05 ± 0.60 for control, 1.18 ± 0.59 for HAEM, 1.00 ± 0.68 for A-PRF+ and 0.95 ± 0.50 for L-PRF sites. No statistically significant difference was detected across groups (P = 0.633). Two weeks after extractions the mean wound healing index was 0.33 ± 0.53 for control, 0.43 ± 0.50 for HAEM, 0.25 ± 0.49 for A-PRF+ and 0.15 ± 0.36 for L-PRF sites. No statistically significant difference across groups was detected (P = 0.255). One week after extractions, nine patients preferred control sites, eight HAEM, ten A-PRF+, four L-PRF and nine had no preference. No statistically significant differences were detected for control sites (P = 0.6779), HAEM (P = 1.0000), A-PRF+ (P = 0.4055) and L-PRF (P = 0.1472). Two weeks after extractions five patients preferred control sites, three HAEM, eight A-PRF+, eight L-PRF and 16 had no preference. No statistically significant differences were detected for control sites (P = 0.8147), HAEM (P = 0.2363), A-PRF+ (P = 0.3488) and L-PRF (P = 0.3488). Costs without counting sutures and blood centrifuges were 0.00, 14.49, 2.44 and 2.44 Euro for control, HAEM, A-PRF+ and L-PRF sites, respectively. CONCLUSIONS: It may not be necessary to discontinue the use of oral antiplatelets in patients undergoing dental extractions and, when present, the minor statistically significant differences between procedures were not clinically relevant; therefore clinicians can use any of the tested interventions according to their preference, keeping in mind that simple suturing is sufficient and is faster and cheaper, and that A-PRF+ was associated with less postoperative bleeding when compared to suturing alone. FAU - Giudice, Amerigo AU - Giudice A FAU - Esposito, Marco AU - Esposito M FAU - Bennardo, Francesco AU - Bennardo F FAU - Brancaccio, Ylenia AU - Brancaccio Y FAU - Buti, Jacopo AU - Buti J FAU - Fortunato, Leonzio AU - Fortunato L LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Int J Oral Implantol (Berl) JT - International journal of oral implantology (Berlin, Germany) JID - 101744702 RN - 0 (Hemostatics) SB - D SB - IM MH - *Hemostatics MH - Humans MH - Leukocytes MH - *Platelet-Rich Fibrin MH - Sutures MH - Tooth Extraction OTO - NOTNLM OT - antiplatelet OT - dental extractions OT - haemorrhage OT - platelet-rich fibrin COIS- Conflict of interest statement: This trial was not funded by any institution or commercial organisation and the authors declare no conflict of interests. EDAT- 2019/05/23 06:00 MHDA- 2019/10/30 06:00 CRDT- 2019/05/23 06:00 PHST- 2019/05/23 06:00 [entrez] PHST- 2019/05/23 06:00 [pubmed] PHST- 2019/10/30 06:00 [medline] AID - 856018 [pii] PST - ppublish SO - Int J Oral Implantol (Berl). 2019;12(1):77-87. PMID- 32433572 OWN - NLM STAT- MEDLINE DCOM- 20201207 LR - 20210520 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 10 IP - 1 DP - 2020 May 20 TI - Effect of antiseptic gels in the microbiologic colonization of the suture threads after oral surgery. PG - 8360 LID - 10.1038/s41598-020-65007-y [doi] LID - 8360 AB - Three different bioadhesive gels were evaluated in a double-blind randomized clinical trial in which microbial growth in the suture thread was assessed following post-surgical application of the aforementioned gels. Also assessed in this trial were, the intensity of post-surgical pain as well as the degree of healing of the patients' surgical wounds. A total of 21 patients (with 42 wisdom teeth) participated in this trial. Chlorhexidine gel, chlorhexidine-chitosan gel, and hyaluronic acid gel were evaluated, with a neutral water-based gel serving as the control agent. The aerobic and facultative anaerobic bacterial recovery on blood agar was lower in the placebo group than in the experimental groups. The most significant difference (p = 0.04) was observed in the chlorhexidine-chitosan group. in which the growth of Blood Agar and Mitis Salivarius Agar was significantly higher than in the placebo group. The intensity of post-surgical pain was very similar among all the groups. Significantly better healing rates were observed in the patients treated with chlorhexidine-chitosan gel when compared with those who used the placebo gel (p = 0.03), and in particular when compared with those patients who used hyaluronic acid gel (p = 0.01). Through our microbiological analyses, we were able to conclude that none of the bioadhesive gels tested resulted in beneficial reductions in the bacterial/fungal populations. However, the healing rates of patients who were treated with chlorhexidine-chitosan were better than those of the patients who used either the placebo gel or the hyaluronic acid gel. FAU - Rodríguez Zorrilla, Samuel AU - Rodríguez Zorrilla S AUID- ORCID: 0000-0001-5869-1025 AD - Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain. samuel.rodriguez.zorrilla@outlook.com. FAU - Blanco Carrión, Andrés AU - Blanco Carrión A AD - Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - García García, Abel AU - García García A AUID- ORCID: 0000-0002-5911-5537 AD - Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). School of Medicine and Dentistry. Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain. FAU - Galindo Moreno, Pablo AU - Galindo Moreno P AD - Department of Oral Surgery and Implant Dentistry, University of Granada, Granada, Spain. FAU - Marichalar Mendía, Xabier AU - Marichalar Mendía X AD - Department of Stomatology II. School of Medicine and Dentistry, Leioa, Bizkaia, Spain. FAU - Seoane Prado, Rafael AU - Seoane Prado R AUID- ORCID: 0000-0001-8719-4503 AD - Microbiology Unit. School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Pérez Estévez, Antonio J AU - Pérez Estévez AJ AD - Microbiology Unit. School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Pérez-Sayáns, Mario AU - Pérez-Sayáns M AUID- ORCID: 0000-0003-2196-9868 AD - Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). School of Medicine and Dentistry. Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain. LA - eng PT - Clinical Trial, Phase IV PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20200520 TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Gels) RN - 0 (Placebos) RN - 9004-61-9 (Hyaluronic Acid) RN - 9012-76-4 (Chitosan) RN - R4KO0DY52L (Chlorhexidine) SB - IM MH - Adolescent MH - Adult MH - Anti-Infective Agents, Local/*administration & dosage MH - Chitosan/administration & dosage MH - Chlorhexidine/administration & dosage MH - Double-Blind Method MH - Female MH - Gels MH - Humans MH - Hyaluronic Acid/administration & dosage MH - Male MH - Pain Measurement MH - Pain, Postoperative/diagnosis/etiology/prevention & control MH - Placebos/administration & dosage MH - Surgical Wound Infection/microbiology/*prevention & control MH - Sutures/*microbiology MH - Tooth Extraction/*adverse effects MH - Wound Healing/*drug effects MH - Young Adult PMC - PMC7239853 COIS- The authors declare no competing interests. EDAT- 2020/05/21 06:00 MHDA- 2020/12/15 06:00 CRDT- 2020/05/21 06:00 PHST- 2019/05/28 00:00 [received] PHST- 2020/04/22 00:00 [accepted] PHST- 2020/05/21 06:00 [entrez] PHST- 2020/05/21 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] AID - 10.1038/s41598-020-65007-y [pii] AID - 65007 [pii] AID - 10.1038/s41598-020-65007-y [doi] PST - epublish SO - Sci Rep. 2020 May 20;10(1):8360. doi: 10.1038/s41598-020-65007-y. PMID- 22855267 OWN - NLM STAT- MEDLINE DCOM- 20140326 LR - 20181202 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 17 IP - 4 DP - 2013 May TI - In vivo hemostatic efficacy of polyurethane foam compared to collagen and gelatin. PG - 1273-8 LID - 10.1007/s00784-012-0809-y [doi] AB - OBJECTIVES: Topical hemostatic agents are used in all surgical disciplines. Most of these hemostats are based on animal-derived products like collagen and gelatin. They carry the potential risk of pathogen transmission. A newly developed biodegradable, fully synthetic hemostatic agent based on polyurethane foam (PU) with 55 % polyethylene glycol (PEG) would prevent these potential risks. MATERIALS AND METHODS: The hemostatic efficacy of this new agent was compared to gelatin and collagen in humans who underwent extraction of an upper and lower molar (split-mouth model). After extraction of a molar in the maxilla and mandible, a PU foam and collagen or gelatin were inserted in the extraction socket for 2 min. Hereafter, the agents were removed and stored in ethylenediaminetetraacetic acid to stop coagulation. Then, the concentration of coagulation parameters thrombin-antithrombin III (TAT) complexes, fibrinogen, and thromboxane B2 (TxB2) in blood extracts from the agents was measured. The concentrations were also determined in baseline blood samples which were collected from the extraction socket. RESULTS: The concentrations of TAT and TxB2 were significantly increased, and fibrinogen concentration was significantly reduced compared to baseline wound blood concentrations indicating enhanced hemostasis. No significant differences were seen in the concentrations of these coagulation parameters in the three different hemostatic agents. CONCLUSIONS: These results show that PU combined with 55 % PEG is a promising alternative for the animal-derived hemostatic agents. CLINICAL RELEVANCE: The synthetic hemostatic agent could replace the animal-derived products like collagen and gelatin and therewith prevent the potential risk of pathogen transmission. FAU - Broekema, Ferdinand I AU - Broekema FI AD - Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands. f.i.broekema@umcg.nl FAU - van Oeveren, Wim AU - van Oeveren W FAU - Selten, Maaike H A AU - Selten MH FAU - Meijer, Rolf J H AU - Meijer RJ FAU - de Wolf, Joost T M AU - de Wolf JT FAU - Bos, Rudolf R M AU - Bos RR LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120802 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Hemostatics) RN - 0 (Polyurethanes) RN - 0 (antithrombin III-protease complex) RN - 3WJQ0SDW1A (Polyethylene Glycols) RN - 54397-85-2 (Thromboxane B2) RN - 9000-70-8 (Gelatin) RN - 9000-94-6 (Antithrombin III) RN - 9001-32-5 (Fibrinogen) RN - 9007-34-5 (Collagen) RN - 9009-54-5 (polyurethane foam) RN - EC 3.4.- (Peptide Hydrolases) SB - D MH - Adult MH - Antithrombin III MH - Blood Chemical Analysis MH - Collagen MH - Female MH - Fibrinogen/analysis MH - Gelatin MH - *Hemostatics/chemistry MH - Humans MH - Linear Models MH - Male MH - Middle Aged MH - Peptide Hydrolases/blood MH - *Polyethylene Glycols MH - *Polyurethanes/chemistry MH - Prospective Studies MH - Statistics, Nonparametric MH - Thromboxane B2/analysis MH - Tooth Extraction MH - Young Adult EDAT- 2012/08/03 06:00 MHDA- 2014/03/29 06:00 CRDT- 2012/08/03 06:00 PHST- 2012/02/09 00:00 [received] PHST- 2012/07/19 00:00 [accepted] PHST- 2012/08/03 06:00 [entrez] PHST- 2012/08/03 06:00 [pubmed] PHST- 2014/03/29 06:00 [medline] AID - 10.1007/s00784-012-0809-y [doi] PST - ppublish SO - Clin Oral Investig. 2013 May;17(4):1273-8. doi: 10.1007/s00784-012-0809-y. Epub 2012 Aug 2. PMID- 27285450 OWN - NLM STAT- MEDLINE DCOM- 20160817 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 6 DP - 2016 Jun 10 TI - Interventions for treating post-extraction bleeding. PG - CD011930 LID - 10.1002/14651858.CD011930.pub2 [doi] AB - BACKGROUND: Post-extraction bleeding (PEB) is a recognised, frequently encountered complication in dental practice, which is defined as bleeding that continues beyond 8 to 12 hours after dental extraction. The incidence of post-extraction bleeding varies from 0% to 26%. If post-extraction bleeding is not managed, complications can range from soft tissue haematomas to severe blood loss. Local causes of bleeding include soft tissue and bone bleeding. Systemic causes include platelet problems, coagulation disorders or excessive fibrinolysis, and inherited or acquired problems (medication induced). There is a wide array of techniques suggested for the treatment of post-extraction bleeding, which include interventions aimed at both local and systemic causes. OBJECTIVES: To assess the effects of interventions for treating different types of post-extraction bleeding. SEARCH METHODS: We searched the following electronic databases: The Cochrane Oral Health Group Trials Register (to 22 March 2016); The Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library 2016, Issue 2); MEDLINE via OVID (1946 to 22 March 2016); CINAHL via EBSCO (1937 to 22 March 2016). Due to the ongoing Cochrane project to search EMBASE and add retrieved clinical trials to CENTRAL, we searched only the last 11 months of EMBASE via OVID (1 May 2015 to 22 March 2016). We placed no further restrictions on the language or date of publication. We searched the US National Institutes of Health Trials Register (http://clinicaltrials.gov), and the WHO Clinical Trials Registry Platform for ongoing trials (http://apps.who.int/trialsearch/default.aspx). We also checked the reference lists of excluded trials. SELECTION CRITERIA: We considered randomised controlled trials (RCTs) that evaluated any intervention for treating PEB, with male or female participants of any age, regardless of type of teeth (anterior or posterior, mandibular or maxillary). Trials could compare one type of intervention with another, with placebo, or with no treatment. DATA COLLECTION AND ANALYSIS: Three pairs of review authors independently screened search records. We obtained full papers for potentially relevant trials. If data had been extracted, we would have followed the methods described in the Cochrane Handbook for Systematic Reviews of Interventions for the statistical analysis. MAIN RESULTS: We did not find any randomised controlled trial suitable for inclusion in this review. AUTHORS' CONCLUSIONS: We were unable to identify any reports of randomised controlled trials that evaluated the effects of different interventions for the treatment of post-extraction bleeding. In view of the lack of reliable evidence on this topic, clinicians must use their clinical experience to determine the most appropriate means of treating this condition, depending on patient-related factors. There is a need for well designed and appropriately conducted clinical trials on this topic, which conform to the CONSORT statement (www.consort-statement.org/). FAU - Sumanth, Kumbargere N AU - Sumanth KN AD - Department of Oral Medicine & Oral Radiology, Faculty of Dentistry, Melaka-Manipal Medical College, Jalan Batu Hampar, Bukit Baru, Melaka, Malaysia, 75150. FAU - Prashanti, Eachempati AU - Prashanti E FAU - Aggarwal, Himanshi AU - Aggarwal H FAU - Kumar, Pradeep AU - Kumar P FAU - Lingappa, Ashok AU - Lingappa A FAU - Muthu, Murugan S AU - Muthu MS FAU - Kiran Kumar Krishanappa, Salian AU - Kiran Kumar Krishanappa S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20160610 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM CIN - Evid Based Dent. 2017 Jun 23;18(2):52-53. PMID: 28642565 UIN - Cochrane Database Syst Rev. 2018 Mar 04;3:CD011930. PMID: 29502332 MH - Female MH - Hemorrhage/etiology/*therapy MH - Humans MH - Male MH - Tooth Extraction/*adverse effects EDAT- 2016/06/11 06:00 MHDA- 2016/08/18 06:00 CRDT- 2016/06/11 06:00 PHST- 2016/06/11 06:00 [entrez] PHST- 2016/06/11 06:00 [pubmed] PHST- 2016/08/18 06:00 [medline] AID - 10.1002/14651858.CD011930.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2016 Jun 10;(6):CD011930. doi: 10.1002/14651858.CD011930.pub2. PMID- 27424879 OWN - NLM STAT- MEDLINE DCOM- 20171010 LR - 20171010 IS - 1875-595X (Electronic) IS - 0020-6539 (Linking) VI - 66 IP - 6 DP - 2016 Dec TI - Relationship between post-extraction pain and acute pulpitis: a randomised trial using third molars. PG - 325-329 LID - 10.1111/idj.12249 [doi] AB - INTRODUCTION: The aim of the present study was to examine the relationship between post-extraction pain and acute pulpitis in third molars. METHODS: This study was a randomised controlled trial. Sixty patients requiring removal of a single maxillary third molar with acute pulpitis were included and randomly divided into two groups: group A (n = 30); and group B (n = 30). In group A, third molars were directly extracted, and group B received endodontic therapy (pulp chamber opening and drainage) and underwent extraction 24 hours later, aiming to eliminate the acute inflammation. Another 30 patients requiring removal of a single maxillary third molar and with the same inclusion criteria but without caries or acute pulpitis were recruited into group C, in which the maxillary third molars were also directly extracted. The level of postoperative pain reported each day among the three groups was statistically evaluated. RESULTS: On the first, second and third days after surgery, there was a statistically significant difference between group A and group B and between group A and group C, but there was no statistically significant difference between group B and group C. CONCLUSION: The results of the present study indicate that there is more pain when third molars with acute pulpitis are directly removed compared with the pain level of the removal of third molars without acute pulpitis. CI - © 2016 FDI World Dental Federation. FAU - Zhang, Wei AU - Zhang W AD - Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China. AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China. FAU - Dai, Yong-Bo AU - Dai YB AD - Department of Stomatology, Huangmei People's Hospital, Huangmei, China. FAU - Wan, Peng-Cheng AU - Wan PC AD - Department of Stomatology, Huangmei People's Hospital, Huangmei, China. FAU - Xu, Dong-Dong AU - Xu DD AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Guo, Yi AU - Guo Y AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Li, Zhi AU - Li Z AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160718 PL - England TA - Int Dent J JT - International dental journal JID - 0374714 SB - D SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*etiology MH - Pulpitis/complications/*surgery MH - Tooth Extraction/*adverse effects/methods MH - Young Adult OTO - NOTNLM OT - Third molars OT - acute pulpitis OT - extraction OT - nerve OT - pain EDAT- 2016/07/19 06:00 MHDA- 2017/10/11 06:00 CRDT- 2016/07/19 06:00 PHST- 2016/07/19 06:00 [pubmed] PHST- 2017/10/11 06:00 [medline] PHST- 2016/07/19 06:00 [entrez] AID - 10.1111/idj.12249 [doi] PST - ppublish SO - Int Dent J. 2016 Dec;66(6):325-329. doi: 10.1111/idj.12249. Epub 2016 Jul 18. PMID- 33058775 OWN - NLM STAT- MEDLINE DCOM- 20210209 LR - 20210209 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 79 IP - 2 DP - 2021 Feb TI - The Use of Low-Level Laser Therapy to Reduce Postoperative Morbidity After Third Molar Surgery: A Systematic Review and Meta-Analysis. PG - 313.e1-313.e19 LID - S0278-2391(20)31136-8 [pii] LID - 10.1016/j.joms.2020.09.018 [doi] AB - PURPOSE: Surgical removal of third molars carries morbidity and significantly affects patients' quality-of-life. This study aims to investigate whether administration of low-level laser therapy (LLLT) is effective in reducing postoperative morbidity in patients undergoing surgical removal of mandibular third molars compared with placebo. MATERIAL AND METHODS: A systematic review and meta-analysis involving a comprehensive search strategy implemented across 5 electronic databases. This was supplemented by hand searching and contacting international experts and grey literature. Titles, abstracts, and full articles were scrutinized for studies meeting the inclusion criteria. All randomized controlled trials comparing treatment group of LLLT with a placebo control group were eligible for inclusion. The outcomes variables were postoperative pain, swelling, and trismus. Risk of bias and methodological quality assessment was carried out. We pooled data statistically, and meta-analyses were carried out using a random-effects model. RESULTS: Seventeen randomized controlled trials were included in this systematic review, all of which were considered to have a low risk of bias. Participants, aged 13 to 70 years, and 35% women, totaled 1064. Meta-analyses found significant reductions in standardized mean differences (SMDs) in swelling at day 2 and day 7 postoperatively (SMD, -0.611; 95% confidence interval, -0.968, -0.234 and SMD, -0.532; 95% confidence interval, -0.795, -0.269). There were nonsignificant reductions in SMD in pain and trismus at day 2 and day 7 postoperatively. CONCLUSIONS: LLLT significantly reduces swelling after extraction of mandibular third molars compared with placebo. LLLT has not shown to reduce postoperative pain and trismus. LLLT does not cause adverse effects. There is currently insufficient evidence available, to promote the investment in LLLT vs the net clinical benefit. Randomized controlled trials with larger sample size and standardized study design and outcome measures are required, to make definitive recommendations to clinicians on its use on patients. CI - Copyright © 2020 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Domah, Farya AU - Domah F AD - Oral Surgery Specialist Registrar, Department of Oral Surgery, University of Birmingham, Birmingham, United Kingdom. FAU - Shah, Raunaq AU - Shah R AD - Private Dental Surgeon, Department of Implantology, College of Medicine & Dentistry, Birmingham, United Kingdom. Electronic address: raunaqshah@hotmail.com. FAU - Nurmatov, Ulugbek B AU - Nurmatov UB AD - Research Fellow, Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom. FAU - Tagiyeva, Nara AU - Tagiyeva N AD - Director, MSc International Public Health, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20200917 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - *Low-Level Light Therapy MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Morbidity MH - Pain, Postoperative/prevention & control MH - *Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control MH - Young Adult EDAT- 2020/10/16 06:00 MHDA- 2021/02/10 06:00 CRDT- 2020/10/15 20:09 PHST- 2020/05/31 00:00 [received] PHST- 2020/09/10 00:00 [revised] PHST- 2020/09/11 00:00 [accepted] PHST- 2020/10/16 06:00 [pubmed] PHST- 2021/02/10 06:00 [medline] PHST- 2020/10/15 20:09 [entrez] AID - S0278-2391(20)31136-8 [pii] AID - 10.1016/j.joms.2020.09.018 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2021 Feb;79(2):313.e1-313.e19. doi: 10.1016/j.joms.2020.09.018. Epub 2020 Sep 17. PMID- 30869171 OWN - NLM STAT- MEDLINE DCOM- 20191126 LR - 20191203 IS - 1365-2842 (Electronic) IS - 0305-182X (Linking) VI - 46 IP - 6 DP - 2019 Jun TI - Therapeutic efficacy of cryotherapy on facial swelling, pain, trismus and quality of life after surgical removal of mandibular third molars: A systematic review. PG - 563-573 LID - 10.1111/joor.12789 [doi] AB - The objective was to test the hypothesis of no difference in facial swelling, pain, trismus and immediate quality of life after surgical removal of mandibular third molars, with or without post-operative cryotherapy. A MEDLINE (PubMed), EMBASE database and Cochrane library search in combination with a hand search of relevant journals were conducted by including human randomised controlled trials published in English until 17 July 2018. The search identified 37 titles. Six studies with low or unclear risk of bias fulfilled the inclusion criteria. Intermittent cryotherapy for 30 minutes during the first post-operative days significantly diminished facial swelling, pain and trismus compared with no cryotherapy. Patient's satisfaction and perception of recovery were significantly increased with cryotherapy. Therapeutic efficacy of intermittent cryotherapy on post-operative facial swelling, pain and trismus seems to be improved compared with continuous cryotherapy. Considerable variations in study design, diversity of used evaluation methods, outcome measures and various methodological confounding factors posed serious restrictions to review the literature in a quantitative systematic manner. Thus, conclusions drawn from the results of this systematic review should be interpreted with caution. Further well-designed randomised controlled trials including standardised protocol, larger patient sample, blinded outcome assessors, patient-reported outcome measures and three-dimensional volumetric analysis of facial swelling are required before evidence-based recommendations can be provided. CI - © 2019 John Wiley & Sons Ltd. FAU - Larsen, Marie Kjaergaard AU - Larsen MK AUID- ORCID: 0000-0002-7024-3089 AD - Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark. FAU - Kofod, Thomas AU - Kofod T AD - Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Starch-Jensen, Thomas AU - Starch-Jensen T AD - Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark. LA - eng PT - Journal Article PT - Systematic Review DEP - 20190403 PL - England TA - J Oral Rehabil JT - Journal of oral rehabilitation JID - 0433604 SB - D SB - IM CIN - J Am Dent Assoc. 2019 Sep;150(9):e134. PMID: 31324335 MH - *Cryotherapy MH - Humans MH - Mandible MH - Molar, Third MH - Pain, Postoperative MH - Quality of Life MH - Randomized Controlled Trials as Topic MH - Tooth Extraction MH - *Tooth, Impacted MH - *Trismus OTO - NOTNLM OT - cryotherapy OT - dentistry OT - mandible OT - pain OT - review OT - third molar OT - trismus EDAT- 2019/03/15 06:00 MHDA- 2019/11/27 06:00 CRDT- 2019/03/15 06:00 PHST- 2018/11/13 00:00 [received] PHST- 2019/01/13 00:00 [revised] PHST- 2019/03/09 00:00 [accepted] PHST- 2019/03/15 06:00 [pubmed] PHST- 2019/11/27 06:00 [medline] PHST- 2019/03/15 06:00 [entrez] AID - 10.1111/joor.12789 [doi] PST - ppublish SO - J Oral Rehabil. 2019 Jun;46(6):563-573. doi: 10.1111/joor.12789. Epub 2019 Apr 3. PMID- 31705869 OWN - NLM STAT- MEDLINE DCOM- 20200917 LR - 20200917 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 2 DP - 2020 Feb TI - Does Watching Videos Increase the Perioperative Anxiety in Patients Undergoing Third Molar Surgery? A Randomized Trial. PG - 216.e1-216.e9 LID - S0278-2391(19)31159-0 [pii] LID - 10.1016/j.joms.2019.09.027 [doi] AB - PURPOSE: The extraction of third molar teeth has usually been associated with a high level of anxiety, mainly from a lack of knowledge. We compared the effect of different informed consent formats on the perioperative anxiety level of patients scheduled for third molar surgery and explored the effects of watching a video about the surgical procedure from the Internet before the procedure on the patients' anxiety level. PATIENTS AND METHODS: A total of 113 patients who had been admitted for the removal of impacted third molars were randomly divided into control (verbal information) and study (video plus verbal information) groups. The anxiety level was assessed using the Amsterdam Preoperative Anxiety and Information Scale, Modified Dental Anxiety Scale, and Spielberger's State-Trait Anxiety Inventory. Pain was evaluated using the visual analog scale (VAS). RESULTS: The results showed that the study group had higher anxiety scores than the control group immediately after the consent process (P < .05). In all groups, the anxiety levels showed a decreasing trend after surgery. The VAS scores did not show significant differences when stratified by gender or educational level. No correlation was observed between age and the other variables. CONCLUSIONS: According to our results, the patients who watched the procedural video in an uncontrolled situation from websites before the operation were prone to high anxiety. The verbal and written consent format resulted in satisfactory anxiety management. Further studies are needed to clarify whether the use of video consent with different formats, such as animation, would be more effective in managing anxiety when applied carefully and under the control of a clinician. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Omezli, Mehmet Melih AU - Omezli MM AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey. FAU - Torul, Damla AU - Torul D AD - Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey. Electronic address: damlatorul@gmail.com. FAU - Kahveci, Kadircan AU - Kahveci K AD - Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20191015 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Anxiety MH - Humans MH - Informed Consent MH - *Molar, Third MH - Tooth Extraction MH - *Tooth, Impacted EDAT- 2019/11/11 06:00 MHDA- 2020/09/18 06:00 CRDT- 2019/11/10 06:00 PHST- 2019/07/24 00:00 [received] PHST- 2019/08/26 00:00 [revised] PHST- 2019/09/18 00:00 [accepted] PHST- 2019/11/11 06:00 [pubmed] PHST- 2020/09/18 06:00 [medline] PHST- 2019/11/10 06:00 [entrez] AID - S0278-2391(19)31159-0 [pii] AID - 10.1016/j.joms.2019.09.027 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Feb;78(2):216.e1-216.e9. doi: 10.1016/j.joms.2019.09.027. Epub 2019 Oct 15. PMID- 29859160 OWN - NLM STAT- MEDLINE DCOM- 20191009 LR - 20191010 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 76 IP - 9 DP - 2018 Sep TI - Evaluation of the Efficacy of Simvastatin in Bone Regeneration after Surgical Removal of Bilaterally Impacted Third Molars-A Split-Mouth Randomized Clinical Trial. PG - 1847-1858 LID - S0278-2391(18)30419-1 [pii] LID - 10.1016/j.joms.2018.04.035 [doi] AB - PURPOSE: Simvastatin has been reported to promote osteoblastic activity, inhibit osteoclastic activity, and support osteoblast differentiation induced by bone morphogenetic protein. This split-mouth randomized clinical trial evaluated the effect of local application of simvastatin (10 mg) on bone regeneration after surgical removal of bilaterally impacted mandibular third molars. MATERIALS AND METHODS: A randomized, split-mouth, single-blinded, single-center trial was performed in 30 patients 18 to 40 years old requiring surgical extraction of bilaterally impacted mandibular third molars. These patients underwent 2 surgical sessions, with extraction of 1 third molar during each session. Each participant was randomly assigned to receive Gelfoam soaked with normal saline or with the drug simvastatin (10 mg) at the first session and were blinded to the use of drug for that particular socket. The alternate regimen was used during the second session. The study was conducted over a period of 3 months. Patients were evaluated for pain, postoperative swelling, and bone density measurement and analysis using intraoral periapical radiographs at the end of 1, 4, 8 and 12 weeks, respectively. In addition, cone-beam computed tomographic (CBCT) images were obtained for every fifth patient at the end of 12 weeks. RESULTS: Mean gray-level histographic values were significantly higher for the study sockets at the end of 1, 4, 8, and 12 weeks (P = .001) compared with the control sockets (30 sockets each). CBCT analysis further substantiated accelerated bone regeneration in the study sockets. CONCLUSION: The study was statistically and radiographically in favor of the drug, indicating that local application of simvastatin could be a cost-effective and simple way to stimulate and hasten osseous regeneration. CI - Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Degala, Saikrishna AU - Degala S AD - Professor and Head of Department, Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital (Constituent College), Jagadguru Sri Shivarathreeshwara University, Mysuru, Karnataka, India. Electronic address: drsaikrishnadegala@gmail.com. FAU - Bathija, Nikita A AU - Bathija NA AD - Postgraduate Student, Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital (Constituent College), Jagadguru Sri Shivarathreeshwara University, Mysuru, Karnataka, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180531 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - AGG2FN16EV (Simvastatin) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Bone Density/drug effects MH - Bone Regeneration/*drug effects MH - Female MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Simvastatin/administration & dosage/*therapeutic use MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Wound Healing/drug effects EDAT- 2018/06/03 06:00 MHDA- 2019/10/11 06:00 CRDT- 2018/06/03 06:00 PHST- 2017/10/27 00:00 [received] PHST- 2018/04/25 00:00 [revised] PHST- 2018/04/25 00:00 [accepted] PHST- 2018/06/03 06:00 [pubmed] PHST- 2019/10/11 06:00 [medline] PHST- 2018/06/03 06:00 [entrez] AID - S0278-2391(18)30419-1 [pii] AID - 10.1016/j.joms.2018.04.035 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2018 Sep;76(9):1847-1858. doi: 10.1016/j.joms.2018.04.035. Epub 2018 May 31. PMID- 30145660 OWN - NLM STAT- MEDLINE DCOM- 20191216 LR - 20200225 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 23 IP - 4 DP - 2019 Apr TI - Guided bone regeneration to reduce root migration after coronectomy of lower third molar: a randomized clinical trial. PG - 1595-1604 LID - 10.1007/s00784-018-2594-8 [doi] AB - PURPOSE: Root migration occurs after most third molar coronectomy and a portion may be exposed in the oral cavity. This study compared the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive guided bone regeneration (GBR). METHODS: A split-mouth randomized clinical trial was conducted on patients with bilateral lower third molars close to the inferior alveolar nerve. One side of the lower third molars was randomized to receive coronectomy with adjunctive GBR (study group) and the other side received coronectomy alone (control group). The cases were followed up for 2 years. Root migration, root exposure rate, surgical morbidities, and adjacent second molar periodontal regeneration were analyzed. RESULTS: Forty-eight subjects (19 males, 29 females) with a mean age of 2.6 years (SD 5.8 years) were recruited. There was no root exposure in the review period. There were no statistical differences in pain and infection rate between the two groups at all time-points. The root migration was significantly less in the study group than the control group from 3 months onwards, and migrated only 1 mm (SD 1.3 mm) in 2 years (versus 3.5 mm (S.D.1.9 mm) in the control group). There were no differences in the periodontal attachment regeneration between the two groups. CONCLUSIONS: Root migration in coronectomy with adjunctive GBR was less when compared with coronectomy alone, and with similar surgical morbidities and periodontal regeneration of adjacent second molars. CLINICAL RELEVANCE: Minimal root migration occurred in coronectomy with adjunctive GBR. The chance of long-term (3 years or more) root exposure and the need of subsequent second operation to remove the exposed root would be reduced. FAU - Leung, Yiu Yan AU - Leung YY AD - Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong. mikeyyleung@hku.hk. LA - eng GR - HKU 788913M/Research Grants Council, University Grants Committee (HK)/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20180825 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - D MH - *Bone Regeneration MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Mandible MH - *Molar, Third MH - Tooth Crown MH - *Tooth Extraction MH - *Tooth Migration MH - Tooth Root OTO - NOTNLM OT - Coronectomy OT - Guided bone regeneration OT - Randomized clinical trial OT - Third molar surgery EDAT- 2018/08/27 06:00 MHDA- 2019/12/18 06:00 CRDT- 2018/08/27 06:00 PHST- 2018/03/27 00:00 [received] PHST- 2018/08/20 00:00 [accepted] PHST- 2018/08/27 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2018/08/27 06:00 [entrez] AID - 10.1007/s00784-018-2594-8 [pii] AID - 10.1007/s00784-018-2594-8 [doi] PST - ppublish SO - Clin Oral Investig. 2019 Apr;23(4):1595-1604. doi: 10.1007/s00784-018-2594-8. Epub 2018 Aug 25. PMID- 28004377 OWN - NLM STAT- MEDLINE DCOM- 20170629 LR - 20170629 IS - 2296-6498 (Print) IS - 2296-6498 (Linking) VI - 126 IP - 12 DP - 2016 TI - [Not Available]. PG - 1147-1159 AB - Extractions of mandibular third molars are a common procedure in dental practice. In cases where a close anatomical relationship of the root and the inferior alveolar nerve exists, the risk of transient or even permanent nerve injury increases. Nerve injury is difficult to manage and symptoms may cause severe patient discomfort, i.e. lifelong dysesthesia, i.e. painful sensation of the lower lip and chin area on the affected side. An alternative surgical procedure is coronectomy, which has first been described 25 year ago. Instead of complete tooth removal only the crown is extracted and the root is intentionally left in situ. A lower incidence of inferior alveolar nerve injury has been found with coronectomy in case of high-risk mandibular third molars, as was shown in randomized controlled trials. Coronectomy is presented in detail with indications as well as contraindications. A patient case is shown and recent literature is discussed. FAU - Wolf, Daniel AU - Wolf D AD - King’s College London Dental Institute, Dept of Oral Surgery, Denmark Hill Campus, London SE59RS, England. FAU - Renton, Tara AU - Renton T LA - ger LA - fre PT - Case Reports PT - Journal Article TT - Die Koronektomie. Eine Behandlungsoption für Weisheitszähne im Unterkiefer bei sehr naher Lagebeziehung zum N.alveolaris inferior. PL - Switzerland TA - Swiss Dent J JT - Swiss dental journal JID - 101624119 SB - D SB - IM MH - Adult MH - Female MH - Humans MH - Mandibular Nerve/diagnostic imaging/*surgery MH - Molar, Third/diagnostic imaging/innervation/*surgery MH - Tooth Crown/diagnostic imaging/*surgery MH - Tooth Extraction/*methods MH - Trigeminal Nerve Injuries/*prevention & control EDAT- 2016/12/23 06:00 MHDA- 2017/07/01 06:00 CRDT- 2016/12/23 06:00 PHST- 2016/12/23 06:00 [entrez] PHST- 2016/12/23 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] AID - sdj-2016-12-03 [pii] PST - ppublish SO - Swiss Dent J. 2016;126(12):1147-1159. PMID- 30501926 OWN - NLM STAT- MEDLINE DCOM- 20190528 LR - 20190528 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 47 IP - 1 DP - 2019 Jan TI - Cyanoacrylate tissue adhesive or silk suture for closure of surgical wound following removal of an impacted mandibular third molar: A randomized controlled study. PG - 93-98 LID - S1010-5182(18)30424-4 [pii] LID - 10.1016/j.jcms.2018.10.018 [doi] AB - AIM: The aim of the study was to compare postoperative sequelae and wound healing outcome following closure of surgical wound with either cyanoacrylate tissue adhesive or silk suture. METHODS: Subjects with mesio-angularly impacted mandibular third molar were allocated randomly into 2 equal groups. The control group had wound closure with silk suture and study group with cyanoacrylate tissue adhesive. Subjects were followed up for 7 postoperative days. Postoperative pain, swelling, trismus, bleeding, wound dehiscence and wound infection were evaluated. RESULTS: Sixty subjects in each group completed the study. No significant difference was observed in the mean postoperative pain, swelling, trismus, wound dehiscence and infection between the 2 groups. There was a statistically significant difference in postoperative bleeding between the 2 groups on postoperative day 1, with more bleeding in the control group. CONCLUSIONS: This study shows that cyanoacrylate tissue adhesive compares favourably with silk suture as a wound closure material. In addition, cyanoacrylate tissue adhesive seems to have beneficial haemostatic effect on postoperative bleeding. CI - Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Oladega, Afisu A AU - Oladega AA AD - Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Lagos, Nigeria. Electronic address: afisuoladega@gmail.com. FAU - James, Olutayo AU - James O AD - Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. FAU - Adeyemo, Wasiu L AU - Adeyemo WL AD - Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20181112 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 RN - 0 (Cyanoacrylates) RN - 0 (Silk) RN - 0 (Tissue Adhesives) SB - D SB - IM MH - Adult MH - Cyanoacrylates/*therapeutic use MH - Edema MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative MH - Postoperative Complications MH - Postoperative Hemorrhage MH - Silk/*chemistry MH - Surgical Wound/*therapy MH - *Sutures MH - Tissue Adhesives/*therapeutic use MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus MH - Wound Closure Techniques/instrumentation OTO - NOTNLM OT - Cyanoacrylate OT - Impacted molar OT - Silk suture OT - Wound closure EDAT- 2018/12/07 06:00 MHDA- 2019/05/29 06:00 CRDT- 2018/12/04 06:00 PHST- 2018/06/10 00:00 [received] PHST- 2018/09/05 00:00 [revised] PHST- 2018/10/30 00:00 [accepted] PHST- 2018/12/07 06:00 [pubmed] PHST- 2019/05/29 06:00 [medline] PHST- 2018/12/04 06:00 [entrez] AID - S1010-5182(18)30424-4 [pii] AID - 10.1016/j.jcms.2018.10.018 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2019 Jan;47(1):93-98. doi: 10.1016/j.jcms.2018.10.018. Epub 2018 Nov 12. PMID- 28126447 OWN - NLM STAT- MEDLINE DCOM- 20180326 LR - 20180326 IS - 1879-1409 (Electronic) IS - 0305-4179 (Linking) VI - 43 IP - 4 DP - 2017 Jun TI - EHTIC study: Evaluation of a new hemostatic agent based on tissue factor in skin grafting procedures. PG - 780-788 LID - S0305-4179(17)30013-X [pii] LID - 10.1016/j.burns.2017.01.007 [doi] AB - BACKGROUND: Excessive bleeding is a major concern in scar debridement and grafting procedures. TT-173 is a new topical hemostatic agent based on recombinant human tissue factor that has shown promising results in patients who underwent tooth extraction. EHTIC study sought to evaluate the efficacy and safety of TT-173 to reduce the bleeding in donor sites of skin grafting procedures. METHODS: EHTIC study was a phase II, randomized, parallel, double blind, placebo controlled trial. Patients received TT-173 (n=38) or placebo (n=33) sprayed over donor site after graft harvest. Time to hemostasis and incidence of adverse events were recorded. Systemic absorption of the product and its immunogenicity were also measured during the follow up of the subjects. RESULTS: Treatment with TT-173 significantly reduced the bleeding time from 7 to 3min (Log-Rank p<0.0001). Moreover, bleeding stopped within the 10min of evaluation period in all the patients that received TT-173. In contrast, 24.24% of patients from placebo group required additional measures to arrest hemorrhage (Fisher p=0.0013). Product related adverse events, systemic absorption into blood stream, interferences with the healing of the donor site or immunogenic reaction against TT-173 were not observed. CONCLUSION: The new hemostatic agent TT-173 has proven efficacious and safe to reduce the bleeding from donor site. This study paves the way for further investigation of the product as topical hemostatic treatment in plastic surgery and other surgical indications. CI - Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved. FAU - Rojas, Santiago AU - Rojas S AD - Thombotargets Europe, S.L., Parque Mediterráneo de la Tecnología, Castelldefels, Spain; Unit of Human Anatomy and Embryology, Department of Morphological Sciences, Faculty of Medicine, Autonomous University of Barcelona, Cerdanyola del Vallès, Spain. Electronic address: santiagorojas@thrombotargets.com. FAU - Pérez Del Caz, M Dolores AU - Pérez Del Caz MD AD - Department of Plastic Surgery, La Fe University and Polytechnic Hospital, Valencia, Spain. FAU - Esteban Vico, Juan Ramón AU - Esteban Vico JR AD - Department of Plastic Surgery, La Fe University and Polytechnic Hospital, Valencia, Spain. FAU - Villaverde, Eloísa AU - Villaverde E AD - Department of Plastic Surgery, La Fe University and Polytechnic Hospital, Valencia, Spain. FAU - Llinas, Abel AU - Llinas A AD - Department of Plastic Surgery, La Fe University and Polytechnic Hospital, Valencia, Spain. FAU - Martínez, José Ramón AU - Martínez JR AD - Department of Plastic Surgery, La Paz University Hospital, Madrid, Spain. FAU - Brage, Carlos AU - Brage C AD - Department of Plastic Surgery, La Paz University Hospital, Madrid, Spain. FAU - Valero, Javier AU - Valero J AD - Department of Plastic Surgery, University Hospital Complex of A Coruña, A Coruña, Spain. FAU - González Rodríguez, Alba AU - González Rodríguez A AD - Department of Plastic Surgery, University Hospital Complex of A Coruña, A Coruña, Spain. FAU - Garcia Barreiro, Juan AU - Garcia Barreiro J AD - Department of Plastic Surgery, University Hospital Complex of A Coruña, A Coruña, Spain. FAU - López-Suso, Eugenia AU - López-Suso E AD - Department of Plastic Surgery, University Hospital Complex of A Coruña, A Coruña, Spain. FAU - Fernandez-Cañamaque, Jose Luis AU - Fernandez-Cañamaque JL AD - Department of Plastic Surgery, University Hospital of Getafe, Getafe, Spain. FAU - López, Ramón AU - López R AD - Thombotargets Europe, S.L., Parque Mediterráneo de la Tecnología, Castelldefels, Spain. FAU - Murat, Jesus AU - Murat J AD - Thombotargets Europe, S.L., Parque Mediterráneo de la Tecnología, Castelldefels, Spain. CN - EHTIC Study Investigators Group LA - eng PT - Clinical Trial, Phase II PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20170123 PL - Netherlands TA - Burns JT - Burns : journal of the International Society for Burn Injuries JID - 8913178 RN - 0 (Hemostatics) RN - 0 (Recombinant Proteins) RN - 9035-58-9 (Thromboplastin) SB - IM MH - Adult MH - Blood Loss, Surgical/*prevention & control MH - Burns/*surgery MH - Double-Blind Method MH - Female MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Recombinant Proteins/*therapeutic use MH - Skin Transplantation/*methods MH - Thromboplastin/*therapeutic use MH - Treatment Outcome MH - Wounds and Injuries/surgery OTO - NOTNLM OT - Surgical bleeding OT - TT-173 OT - Thrombin OT - Tissue factor OT - Topical hemostatic EDAT- 2017/01/28 06:00 MHDA- 2018/03/27 06:00 CRDT- 2017/01/28 06:00 PHST- 2016/10/10 00:00 [received] PHST- 2016/11/21 00:00 [revised] PHST- 2017/01/05 00:00 [accepted] PHST- 2017/01/28 06:00 [pubmed] PHST- 2018/03/27 06:00 [medline] PHST- 2017/01/28 06:00 [entrez] AID - S0305-4179(17)30013-X [pii] AID - 10.1016/j.burns.2017.01.007 [doi] PST - ppublish SO - Burns. 2017 Jun;43(4):780-788. doi: 10.1016/j.burns.2017.01.007. Epub 2017 Jan 23. PMID- 32070661 OWN - NLM STAT- MEDLINE DCOM- 20200917 LR - 20200921 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 48 IP - 3 DP - 2020 Mar TI - Preemptive use of oral nonsteroidal anti-inflammatory drugs for the relief of inflammatory events after surgical removal of lower third molars: A systematic review with meta-analysis of placebo-controlled randomized clinical trials. PG - 293-307 LID - S1010-5182(20)30024-X [pii] LID - 10.1016/j.jcms.2020.01.016 [doi] AB - PURPOSE: To investigate the effectiveness of preemptive analgesia with nonsteroidal anti-inflammatory drugs (NSAIDs) for the relief of inflammatory events (pain, edema, and trismus) after surgical removal of third molars. MATERIALS AND METHODS: A two-phase PROSPERO-registered systematic review was conducted in accordance with the PRISMA statement. PubMed, Scopus, Web of Science, COCHRANE, LILACS, DOSS, and gray literature were searched using the following terms (MeSH) or their combinations: molar, third; anti-inflammatory agents, non-steroidal; analgesia; preoperative period; pain management. RESULTS: From a total of 2903 articles, 31 (n = 2184 subjects) were selected. All studies presented a low risk of bias but exhibited high heterogeneity in methodology. Ten studies were selected for the meta-analysis. Preemptive analgesia for removal of third molars reduced average pain scores, especially those 1 h and 6 h after surgery (n = 151, p < 0.001, 95% CI = -2.81 to -0.97), reduced the average consumption of medication, and decreased the number of patients requiring medication without affecting the average time for its first consumption. CONCLUSION: In summary, most NSAIDs showed good results for inflammatory events and reduced average pain scores and consumption of rescue medication. However, more homogeneous and well-delineated clinical studies are necessary to determine a possible association between NSAIDs and the relief of inflammatory events. CI - Copyright © 2020. Published by Elsevier Ltd. FAU - Cetira Filho, Edson Luiz AU - Cetira Filho EL AD - Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. FAU - Carvalho, Francisco Samuel Rodrigues AU - Carvalho FSR AD - Division of Oral and Maxillofacial Surgery, Federal University of Ceará Campus Sobral, Sobral, CE, Brazil. Electronic address: samuel.rcarvalho@gmail.com. FAU - de Barros Silva, Paulo Goberlânio AU - de Barros Silva PG AD - UNICHRISTUS, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. FAU - Barbosa, Daniel Almeida Ferreira AU - Barbosa DAF AD - Paulo Picanço University, Postgraduate Student, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. FAU - Alves Pereira, Karuza Maria AU - Alves Pereira KM AD - Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. FAU - Ribeiro, Thyciana Rodrigues AU - Ribeiro TR AD - Division of Patients with Special Needs, Department of Clinical Dentistry, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. FAU - Costa, Fábio Wildson Gurgel AU - Costa FWG AD - Division of Oral Radiology, Department of Clinical Dentistry, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20200201 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) SB - D SB - IM MH - Anti-Inflammatory Agents/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Humans MH - *Molar, Third MH - Pain, Postoperative/drug therapy MH - Randomized Controlled Trials as Topic MH - Trismus OTO - NOTNLM OT - Analgesia OT - Nonsteroidal anti-inflammatory drugs OT - Pain management OT - Preoperative period OT - Third molar COIS- Declaration of Competing Interest None. EDAT- 2020/02/20 06:00 MHDA- 2020/09/18 06:00 CRDT- 2020/02/20 06:00 PHST- 2019/08/04 00:00 [received] PHST- 2019/12/23 00:00 [revised] PHST- 2020/01/25 00:00 [accepted] PHST- 2020/02/20 06:00 [pubmed] PHST- 2020/09/18 06:00 [medline] PHST- 2020/02/20 06:00 [entrez] AID - S1010-5182(20)30024-X [pii] AID - 10.1016/j.jcms.2020.01.016 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2020 Mar;48(3):293-307. doi: 10.1016/j.jcms.2020.01.016. Epub 2020 Feb 1. PMID- 33181593 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 2689-8381 (Electronic) IS - 2689-8381 (Linking) VI - 18 IP - 11 DP - 2020 Nov TI - Effectiveness of hemostatic protocols for the prevention of bleeding during oral procedures among individuals receiving anticoagulation therapy: a systematic review protocol. PG - 2409-2415 LID - 10.11124/JBISRIR-D-19-00342 [doi] AB - OBJECTIVE: The objective of this review is to determine the effectiveness of hemostatic protocols for the prevention of bleeding during dental procedures among individuals receiving oral anticoagulation therapy. INTRODUCTION: Dental procedures may increase the chance of bleeding in individuals receiving oral anticoagulation therapy. The literature suggests different hemostatic protocols for the prevention of bleeding in these individuals but offers no consensus regarding their effectiveness. INCLUSION CRITERIA: Randomized controlled clinical trials comparing the effectiveness of different hemostatic protocols for the prevention of bleeding during oral procedures among individuals 18 years or older receiving oral anticoagulation therapy will be included. METHODS: Computerized searches will be conducted in seven electronic databases. Gray literature and searches in the reference lists of the included articles will also be screened. Two independent reviewers will assess titles/abstracts for potential inclusion against the eligibility criteria. References that meet the eligibility criteria will be included without restriction on the language or date of publication. Assessment of the methodological quality of the included articles and data extraction will be performed. Statistical heterogeneity of meta-analysis will be assessed. In the event of high statistical heterogeneity, sensitivity analysis will be performed. Subgroup analysis will be planned. The certainty of the evidence will be evaluated with the Grading of Recommendations, Assessment, Development and Evaluation. SYSTEMATIC REVIEW REGISTRATION NUMBER: PROSPERO CRD42019136744. FAU - Moreno-Drada, Johana Alejandra AU - Moreno-Drada JA AD - Department of Community and Preventive Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Abreu, Lucas Guimarães AU - Abreu LG AD - Department of Pediatric Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Martins, Maria Auxiliadora Parreiras AU - Martins MAP AD - Department of Pharmaceutical Products, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Pordeus, Isabela Almeida AU - Pordeus IA AD - Department of Pediatric Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - de Abreu, Mauro Henrique Nogueira Guimarães AU - de Abreu MHNG AD - Department of Community and Preventive Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - JBI Evid Synth JT - JBI evidence synthesis JID - 101764819 RN - 0 (Anticoagulants) RN - 0 (Hemostatics) SB - IM MH - Anticoagulants/adverse effects MH - Hemorrhage/chemically induced MH - *Hemostatics/adverse effects MH - Humans MH - Meta-Analysis as Topic MH - Review Literature as Topic EDAT- 2020/11/13 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/11/12 20:17 PHST- 2020/11/12 20:17 [entrez] PHST- 2020/11/13 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] AID - 02174543-202011000-00015 [pii] AID - 10.11124/JBISRIR-D-19-00342 [doi] PST - ppublish SO - JBI Evid Synth. 2020 Nov;18(11):2409-2415. doi: 10.11124/JBISRIR-D-19-00342. PMID- 10595866 OWN - NLM STAT- MEDLINE DCOM- 20000124 LR - 20181113 IS - 0012-6667 (Print) IS - 0012-6667 (Linking) VI - 58 IP - 5 DP - 1999 Nov TI - Fibrin sealant: a review of its use in surgery and endoscopy. PG - 863-86 AB - Fibrin sealant (fibrin adhesive; fibrin glue; Beriplast P1) is a haemostatic and wound support product consisting of the blood coagulation factors fibrinogen, factor XIII and thrombin, the antifibrinolytic agent aprotinin and calcium chloride. Fibrin sealant has been used to good effect in a wide variety of surgical and endoscopic procedures. Suture support was provided in series of patients with oesophageal, gastric, colonic or rectal anastomoses, and fibrin sealant was as effective in haemostasis as microcrystalline collagen powder in hepatic surgery. It did not reduce postoperative peritoneal drainage after elective cholecystectomy, however. A 41% reduction (p<0.02) in incidence of air leakage was achieved when fibrin sealant was added to sutures in patients undergoing pulmonary resection in a randomised single-blind study. A high rate of complete remission of malignant pleural effusion has been reported after intrapleural instillation of fibrin sealant, and successful sealing of CSF leaks after trauma or surgery has also been achieved. Attenuation of prolonged or excessive haemorrhage after dental extraction has been achieved in patients on anticoagulant therapy or with haemorrhagic disorders who received fibrin sealant with packing and suturing. Repeated endoscopic injection of fibrin sealant was superior to single injection sclerotherapy with polidocanol 1% in a randomised study in 805 patients with bleeding peptic ulcers. Other data suggest that endoscopic injection of fibrin sealant is associated with lower recurrence of bleeding and need for emergency surgery than thrombin with adrenaline (epinephrine) or hypertonic saline with adrenaline. Similar haemostatic efficacy to laser photocoagulation or sclerotherapy was reported in a retrospective comparison. A statistically significant reduction relative to suturing in the incidence of wound dehiscence was reported after the use of fibrin sealant in cataract surgery, and benefit of the sealant has also been noted in patients receiving skin grafts and in those undergoing transurethral resection of the prostate gland. CONCLUSIONS: Although comparative studies would assist in the clarification of the place of the product discussed with respect to other haemostatic or wound support techniques and to other fibrin sealants, the formulation reviewed here has been shown overall to be effective and well tolerated in a variety of haemostatic and wound healing support roles in numerous types of surgery. Fibrin sealant has also been shown to be useful when administered endoscopically, with superiority over sclerotherapy being shown after repeated application in patients with peptic ulceration. Fibrin sealant can therefore be considered useful in a number of surgical and endoscopic settings. FAU - Dunn, C J AU - Dunn CJ AD - Adis International Limited, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz FAU - Goa, K L AU - Goa KL LA - eng PT - Journal Article PT - Review PL - New Zealand TA - Drugs JT - Drugs JID - 7600076 RN - 0 (Fibrin Tissue Adhesive) RN - 0 (Hemostatics) RN - 0 (Tissue Adhesives) SB - IM MH - Animals MH - Endoscopy/*methods MH - *Fibrin Tissue Adhesive/administration & dosage/adverse effects/pharmacology/therapeutic use MH - *Hemostatics/administration & dosage/adverse effects/pharmacology/therapeutic use MH - Humans MH - Randomized Controlled Trials as Topic MH - *Surgical Procedures, Operative MH - *Tissue Adhesives/adverse effects/pharmacology/therapeutic use RF - 86 EDAT- 1999/12/14 00:00 MHDA- 1999/12/14 00:01 CRDT- 1999/12/14 00:00 PHST- 1999/12/14 00:00 [pubmed] PHST- 1999/12/14 00:01 [medline] PHST- 1999/12/14 00:00 [entrez] AID - 10.2165/00003495-199958050-00010 [doi] PST - ppublish SO - Drugs. 1999 Nov;58(5):863-86. doi: 10.2165/00003495-199958050-00010. PMID- 31962377 OWN - NLM STAT- MEDLINE DCOM- 20201102 LR - 20201102 IS - 1365-2516 (Electronic) IS - 1351-8216 (Linking) VI - 26 IP - 2 DP - 2020 Mar TI - Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence-based practice? A review of the literature. PG - 183-199 LID - 10.1111/hae.13928 [doi] AB - Due to the global prevalence of oral disease, tooth extraction is the most common surgical procedure required in general population thus likely to be similarly common in patients with haemophilia, especially those in older age and those living in countries with restricted resources. There are little or no consensus about optimal level and duration of factor replacement (FRP) therapy required to prevent bleeding complication following surgery and low levels of evidence to inform protocols and guidelines. The goal of this article was to review the literature regarding haematological treatment protocols and to assess their effectiveness in prevention of bleeding complications during and after tooth extractions in people with haemophilia. A total number of 29 articles were identified. Only two of the studies were randomized controlled trials, and meta-analysis was not possible. Significant heterogeneity regarding haematological regimes, dental surgical procedures, disease severity and sample size of published studies which are unable to reliably inform the provision of safe dental surgery was noted. Based on the haematological regimens, all studies were classified into one of three groups: pre- and postoperative FRP or DDAVP, single preoperative FRP or DDAVP, and no FRP treatment. The overall reported bleeding rate in case of both pre- and postoperative FRP and single dose FRP preoperative is similar, 11.9% and 11.4%, respectively, indicating that minimizing the use of clotting factor concentrate is possible if proper local haemostatic measures are provided. Strictly designed prospective studies with higher number of patients are necessary to get firm conclusions about optimal FRP treatment required to prevent bleeding complications during and after oral surgery in patients with haemophilia. CI - © 2020 John Wiley & Sons Ltd. FAU - Bajkin, Branislav AU - Bajkin B AUID- ORCID: 0000-0003-2189-6769 AD - Faculty of Medicine Novi Sad, University of Novi Sad, Dental Clinic of Vojvodina, Novi Sad, Serbia. FAU - Dougall, Alison AU - Dougall A AD - Special Care Dentistry Division of Child and Public Dental Health, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland. LA - eng PT - Journal Article PT - Review DEP - 20200121 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM MH - Consensus MH - Evidence-Based Medicine/*methods MH - Hemophilia A/*complications MH - Humans MH - Tooth Extraction/*methods OTO - NOTNLM OT - haemophilia OT - inherited blood coagulation disorders OT - oral haemorrhage OT - oral surgery OT - surgical haemostasis OT - tooth extraction EDAT- 2020/01/22 06:00 MHDA- 2020/11/03 06:00 CRDT- 2020/01/22 06:00 PHST- 2019/10/14 00:00 [received] PHST- 2019/12/17 00:00 [revised] PHST- 2020/01/03 00:00 [accepted] PHST- 2020/01/22 06:00 [pubmed] PHST- 2020/11/03 06:00 [medline] PHST- 2020/01/22 06:00 [entrez] AID - 10.1111/hae.13928 [doi] PST - ppublish SO - Haemophilia. 2020 Mar;26(2):183-199. doi: 10.1111/hae.13928. Epub 2020 Jan 21. PMID- 33057887 OWN - NLM STAT- MEDLINE DCOM- 20210318 LR - 20210318 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 25 IP - 4 DP - 2021 Apr TI - Effect of St. John's wort oil and olive oil on the postoperative complications after third molar surgery: randomized, double-blind clinical trial. PG - 2429-2438 LID - 10.1007/s00784-020-03639-0 [doi] AB - OBJECTIVES: This multicenter study aimed to evaluate the effects of St. John's wort oil and virgin olive oil on the postoperative complications and compare this with chlorhexidine gluconate plus benzydamine hydrochloride mouthwash after the removal of impacted third molar. METHODS: A total of 90 patients in need of impacted third molar surgery were included in this study. All included patients were randomly divided into 3 groups. The patients in group 1 received St. John's wort oil; the patients in group 2 received virgin olive oil, and those in group 3 received mouthwash containing chlorhexidine gluconate plus benzydamine hydrochloride. The self-reported pain and difficulty during jaw function, trismus, facial swelling, number of analgesics used during first postoperative week, and postoperative periodontal condition including plaque accumulation, bleeding on probing, and periodontal pocket depth were compared between the groups. RESULTS: No significant differences were found regarding the study variables. CONCLUSIONS: The data of the present study supports that the use of essential oils provides efficient alternative to the gold standard chlorhexidine gluconate mouthwash in reducing postoperative complications and improving healing process without adverse effects after surgical removal of impacted third molars. CLINICAL RELEVANCE: The use of essential oils showed similar results as the chlorhexidine gluconate mouthwash regarding swelling, mouth opening, pain, need for rescue medication, infectious complications (i.e., alveolar osteitis), and periodontal healing. Therefore, essential oils can be an alternative to routine mouthwashes to ensure oral hygiene after impacted third molar surgery. FAU - Kaplan, Volkan AU - Kaplan V AUID- ORCID: 0000-0002-7605-1125 AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Tekirdag Namik Kemal University, Tekirdag, Turkey. dr.volkankaplan61@gmail.com. FAU - Hasanoglu Erbasar, Guzin Neda AU - Hasanoglu Erbasar GN AUID- ORCID: 0000-0003-0743-199X AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara Yıldırım Beyazıt University, Ankara, Turkey. FAU - Cigerim, Levent AU - Cigerim L AUID- ORCID: 0000-0001-5218-8568 AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Van Yuzuncu Yil University, Van, Turkey. FAU - Altay Turgut, Hilal AU - Altay Turgut H AUID- ORCID: 0000-0002-6759-0848 AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara Yıldırım Beyazıt University, Ankara, Turkey. FAU - Cerit, Abdullah AU - Cerit A AUID- ORCID: 0000-0003-3851-6961 AD - Internal Medicine Specialist, Private Practice, Istanbul, Turkey. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20201015 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Olive Oil) SB - D MH - Double-Blind Method MH - Humans MH - *Hypericum MH - Molar, Third/surgery MH - Olive Oil MH - Postoperative Complications/prevention & control MH - *Tooth, Impacted/surgery OTO - NOTNLM OT - Chlorhexidine OT - Impacted tooth OT - Olive oil OT - Postoperative complications OT - St. John’s wort EDAT- 2020/10/16 06:00 MHDA- 2021/03/19 06:00 CRDT- 2020/10/15 17:38 PHST- 2020/06/25 00:00 [received] PHST- 2020/10/07 00:00 [accepted] PHST- 2020/10/16 06:00 [pubmed] PHST- 2021/03/19 06:00 [medline] PHST- 2020/10/15 17:38 [entrez] AID - 10.1007/s00784-020-03639-0 [pii] AID - 10.1007/s00784-020-03639-0 [doi] PST - ppublish SO - Clin Oral Investig. 2021 Apr;25(4):2429-2438. doi: 10.1007/s00784-020-03639-0. Epub 2020 Oct 15. PMID- 31654645 OWN - NLM STAT- MEDLINE DCOM- 20200917 LR - 20200917 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 1 DP - 2020 Jan TI - Comparison of Low Pre-Emptive Oral Doses of Celecoxib Versus Acetaminophen for Postoperative Pain Management After Third Molar Surgery: A Randomized Controlled Study. PG - 75.e1-75.e6 LID - S0278-2391(19)31148-6 [pii] LID - 10.1016/j.joms.2019.09.022 [doi] AB - PURPOSE: This study aimed to compare the pre-emptive analgesia of oral celecoxib with oral acetaminophen after surgical removal of the mandibular third molars. MATERIALS AND METHODS: A randomized, double-blinded, placebo-controlled clinical trial was conducted to examine patients presenting with a mandibular third molar for extraction under local anesthesia. The participants were randomized to receive a preoperative oral dose of celecoxib or acetaminophen as the predictor variable. The primary outcome variable was postoperative pain measured on a visual analog scale at different time points. The secondary outcome variable was the amount of postoperative analgesic medication taken in both groups. Statistical analyses included descriptive statistics, the t test, and the Pearson χ(2) test. Significance was set at P < .05. The overall survival (interval to the first intake of ibuprofen) of the patients in each group was evaluated using Kaplan-Meier curves and log-rank analyses. RESULTS: Sixty participants were randomly divided into either the celecoxib group or acetaminophen group. The postoperative pain scores in the celecoxib group were significantly lower than those in the acetaminophen group at 4, 6, 8, and 12 hours (P = .008, P = .001, P = .021, and P = .011, respectively). The number of patients who did not require analgesics in the celecoxib group was less than that in the acetaminophen group (P = .018). The average amount of rescue analgesic medication in the celecoxib group (0.6 ± 0.8 dose) was significantly lower than that in the acetaminophen group (1.3 ± 1.0 doses) (P = .002). The Kaplan-Meier curve indicated that celecoxib resulted in long-term survival of the patients who did not receive rescue analgesic medication (P = .0055). CONCLUSIONS: Celecoxib exhibits a significant pre-emptive analgesic effect, thereby reducing the use of postoperative analgesics after removal of the third molar. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Xie, Long AU - Xie L AD - Attending Physician, State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Yang, Rong-Tao AU - Yang RT AD - Associate Professor, State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Lv, Kun AU - Lv K AD - Associate Professor, State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Zhou, Hai-Hua AU - Zhou HH AD - Associate Professor, State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Li, Zhi AU - Li Z AD - Chief Physician, State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address: zhili@whu.edu.cn. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190927 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) RN - JCX84Q7J1L (Celecoxib) SB - AIM SB - D SB - IM MH - Acetaminophen MH - *Analgesics, Non-Narcotic MH - Celecoxib MH - Double-Blind Method MH - Humans MH - *Molar, Third MH - Pain, Postoperative MH - Tooth Extraction EDAT- 2019/10/28 06:00 MHDA- 2020/09/18 06:00 CRDT- 2019/10/27 06:00 PHST- 2019/08/05 00:00 [received] PHST- 2019/09/22 00:00 [revised] PHST- 2019/09/23 00:00 [accepted] PHST- 2019/10/28 06:00 [pubmed] PHST- 2020/09/18 06:00 [medline] PHST- 2019/10/27 06:00 [entrez] AID - S0278-2391(19)31148-6 [pii] AID - 10.1016/j.joms.2019.09.022 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Jan;78(1):75.e1-75.e6. doi: 10.1016/j.joms.2019.09.022. Epub 2019 Sep 27. PMID- 32839834 OWN - NLM STAT- MEDLINE DCOM- 20210318 LR - 20210318 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 25 IP - 4 DP - 2021 Apr TI - Evaluation of different mandibular blocks for the removal of lower third molars: a meta-analysis of randomised clinical trials. PG - 2129-2139 LID - 10.1007/s00784-020-03525-9 [doi] AB - OBJECTIVES: To describe the efficacy and number of side effects for the Gow-Gates mandibular block (GGMB) and Vazirani-Akinosi mandibular block (VAMB) compared to inferior alveolar nerve block (IANB) in patients requiring lower third molar (L3M) extraction. MATERIALS AND METHODS: A systematic search was performed in three electronic databases and complemented with a manual search. The inclusion criteria were randomised clinical trials in healthy patients who underwent at least one L3M extraction. Screening and article selection were carried out by two independent reviewers. After data extraction, a meta-analysis was performed for the success rate, number of positive aspirations, and onset time outcomes. RESULTS: Six randomised clinical trials were included out of the 367 potentially eligible papers. No significant differences were found in terms of success rate using GGMB (risk ratio [RR] 1.04; 95% confidence interval [CI] 0.92 to 1.18; P = 0.48) nor VAMB (RR 0.96; 95% CI 0.86 to 1.06; P = 0.41). The VAMB group exhibited a lower number of positive aspirations than the IANB group (RR 0.08; 95% CI 0.01 to 0.55; P = 0.01), but there was no statistically significant difference between the GGMB and IANB groups (RR 1.06; 95% CI 0.13 to 8.78; P = 0.96). The delayed onset was even longer in GGMB (mean difference [MD] 3.32 min; 95% CI 1.98 to 4.66; P < 0.001) and VAMB (MD 0.90 min; 95% CI 0.37 to 1.43; P = 0.0001) than IANB. CONCLUSIONS: GGMB and VAMB seem to be effective and safe anaesthetic techniques for the removal of L3M, but these blocks exhibited a more delayed onset time than IANB. CLINICAL RELEVANCE: GGMB and VAMB are safe and effective anaesthetic techniques for the removal of L3M. However, IANB can still be considered the first option since GGMB and VAMB exhibited more delayed onset times and variable buccal nerve anaesthesia. FAU - Cavallini, Carolina-Noemi AU - Cavallini CN AD - EFHRE International University/FUCSO, Belize City, Belize. FAU - Toledano-Serrabona, Jorge AU - Toledano-Serrabona J AUID- ORCID: 0000-0002-0166-8876 AD - EFHRE International University/FUCSO, Belize City, Belize. jorgetoledano25@gmail.com. AD - School of Medicine and Health Sciences, Campus de Bellvitge, University of Barcelona, C/Feixa Llarga, s/n; Pavelló Govern, 2ª planta, Despatx 2.9, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. jorgetoledano25@gmail.com. AD - IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain. jorgetoledano25@gmail.com. AD - Oral and Maxillofacial Surgery Department, University of Barcelona, Barcelona, Spain. jorgetoledano25@gmail.com. FAU - Gay-Escoda, Cosme AU - Gay-Escoda C AD - EFHRE International University/FUCSO, Belize City, Belize. AD - School of Medicine and Health Sciences, Campus de Bellvitge, University of Barcelona, C/Feixa Llarga, s/n; Pavelló Govern, 2ª planta, Despatx 2.9, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. AD - IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain. AD - Oral and Maxillofacial Surgery Department, University of Barcelona, Barcelona, Spain. AD - Oral Surgery, Implantology and Maxillofacial Surgery Department, Teknon Medical Centre, Barcelona, Spain. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20200825 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Anesthetics, Local) SB - D MH - *Anesthesia, Dental MH - Anesthetics, Local MH - Humans MH - Mandibular Nerve MH - Molar, Third/surgery MH - *Nerve Block MH - *Pulpitis/surgery MH - Randomized Controlled Trials as Topic OTO - NOTNLM OT - Anaesthetic technique OT - Gow-Gates mandibular block OT - Inferior alveolar nerve block OT - Lower third molar OT - Mandibular block OT - Vazirani-Akinosi mandibular block EDAT- 2020/08/26 06:00 MHDA- 2021/03/19 06:00 CRDT- 2020/08/26 06:00 PHST- 2020/03/27 00:00 [received] PHST- 2020/08/11 00:00 [accepted] PHST- 2020/08/26 06:00 [pubmed] PHST- 2021/03/19 06:00 [medline] PHST- 2020/08/26 06:00 [entrez] AID - 10.1007/s00784-020-03525-9 [pii] AID - 10.1007/s00784-020-03525-9 [doi] PST - ppublish SO - Clin Oral Investig. 2021 Apr;25(4):2129-2139. doi: 10.1007/s00784-020-03525-9. Epub 2020 Aug 25. PMID- 26867667 OWN - NLM STAT- MEDLINE DCOM- 20170110 LR - 20170111 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 45 IP - 5 DP - 2016 May TI - Removal versus retention of asymptomatic third molars in mandibular angle fractures: a randomized controlled trial. PG - 571-4 LID - S0901-5027(16)00028-X [pii] LID - 10.1016/j.ijom.2016.01.007 [doi] AB - The treatment dilemma provided by asymptomatic third molars in mandibular angle fractures remains controversial. This prospective randomized controlled trial was undertaken to determine whether there is an advantage to extraction or retention of the third molar whilst repairing a mandibular angle fracture. Sixty-four patients were allocated randomly to the two treatment groups. All underwent open reduction and internal fixation (ORIF) with standard postoperative care. The primary outcome measure was uncomplicated fracture healing. Secondary measures were surgical duration, malocclusion, wound healing, nerve injury, and return to theatre. All patients had uncomplicated fracture healing. The incidence of nerve injury was 16% for the retention group compared with 39% for the removal group (P=0.038). The average operating time for ORIF and third molar retention cases was 58.5min and for ORIF and third molar removal cases was 66.3min (P=0.26). There was no statistically significant difference between groups for wound healing, occlusion outcomes, or return to theatre. Given the additional risk of nerve injury and the additional operating time required for removal of a third molar, in the absence of an absolute indicator for removal of the third molar, it appears justifiable to advise retaining the tooth in the line of a mandibular angle fracture. CI - Copyright © 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - McNamara, Z AU - McNamara Z AD - Department of Oral and Maxillofacial Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. Electronic address: zebmcnamara@hotmail.com. FAU - Findlay, G AU - Findlay G AD - Department of Oral and Maxillofacial Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. FAU - O'Rourke, P AU - O'Rourke P AD - Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. FAU - Batstone, M AU - Batstone M AD - Department of Oral and Maxillofacial Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160209 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Incidence MH - *Jaw Fixation Techniques MH - Male MH - Mandibular Fractures/*surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Postoperative Complications/epidemiology MH - Prospective Studies MH - Tooth Extraction MH - Treatment Outcome MH - Trigeminal Nerve Injuries/epidemiology OTO - NOTNLM OT - internal fixation OT - mandibular angle fractures OT - randomized controlled trial OT - third molars EDAT- 2016/02/13 06:00 MHDA- 2017/01/11 06:00 CRDT- 2016/02/13 06:00 PHST- 2015/07/11 00:00 [received] PHST- 2015/11/11 00:00 [revised] PHST- 2016/01/14 00:00 [accepted] PHST- 2016/02/13 06:00 [entrez] PHST- 2016/02/13 06:00 [pubmed] PHST- 2017/01/11 06:00 [medline] AID - S0901-5027(16)00028-X [pii] AID - 10.1016/j.ijom.2016.01.007 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2016 May;45(5):571-4. doi: 10.1016/j.ijom.2016.01.007. Epub 2016 Feb 9. PMID- 16876044 OWN - NLM STAT- MEDLINE DCOM- 20060816 LR - 20151119 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 102 IP - 2 DP - 2006 Aug TI - Minor complications after mandibular third molar surgery: type, incidence, and possible prevention. PG - e4-11 AB - PURPOSE: The aim of this prospective study was to ascertain the incidence of minor complications after mandibular third molar surgery and to predict the risk of skin ecchymosis or mucosa petechiae related to the usage of an absorbable gelatin sponge. PATIENTS AND METHODS: One hundred and four patients subjected to surgical extraction of horizontally impacted lower third molars were selected and investigated by means of questionnaires and clinical examinations. The independent sample t test was used for numeric variables. The chi-square test was used for logistic variables to determine the association between variables, and thereafter stepwise logistical regression was used. RESULTS: The older group (> or = 30 years old), with deeply impacted teeth, and long operation times (> or = 10 minutes) were shown to have significantly higher swelling than the other groups (P < .05). The patients who had deeply impacted teeth or long operation times were shown to have significantly higher VAS scores compared to short operation times (P < .05). The use of an absorbable gelatin sponge in the extraction socket significantly decreased postoperative swelling, mucosal petechiae, and skin ecchymosis (P < .05). CONCLUSION: The clinical variables related to postoperative bleeding disorder, pain, and trismus were identified. The insertion of an absorbable gelatin sponge into the extraction socket was found to be a very useful method to prevent postoperative bleeding problems. FAU - Kim, Jin-Cheol AU - Kim JC AD - Department of Oral and Maxillofacial Surgery, Sacred Heart Hospital, Hallym University, Kyungki-do, Republic of Korea. FAU - Choi, Seong-Seok AU - Choi SS FAU - Wang, Soon-Joo AU - Wang SJ FAU - Kim, Seong-Gon AU - Kim SG LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20060627 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Hemostatics) SB - D SB - IM MH - Adult MH - Chi-Square Distribution MH - Ecchymosis/etiology/*prevention & control MH - Edema/etiology MH - Female MH - Gelatin Sponge, Absorbable/*therapeutic use MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Prospective Studies MH - Purpura/etiology/*prevention & control MH - Regression Analysis MH - Surveys and Questionnaires MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Trismus/etiology EDAT- 2006/08/01 09:00 MHDA- 2006/08/17 09:00 CRDT- 2006/08/01 09:00 PHST- 2005/07/25 00:00 [received] PHST- 2005/09/30 00:00 [revised] PHST- 2005/10/18 00:00 [accepted] PHST- 2006/08/01 09:00 [pubmed] PHST- 2006/08/17 09:00 [medline] PHST- 2006/08/01 09:00 [entrez] AID - S1079-2104(05)00939-X [pii] AID - 10.1016/j.tripleo.2005.10.050 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Aug;102(2):e4-11. doi: 10.1016/j.tripleo.2005.10.050. Epub 2006 Jun 27. PMID- 16781338 OWN - NLM STAT- MEDLINE DCOM- 20060725 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 64 IP - 7 DP - 2006 Jul TI - Impact of topical minocycline with third molar surgery on clinical recovery and health-related quality of life outcomes. PG - 1059-65 AB - PURPOSE: Compare recovery for clinical and health-related quality of life (HRQOL) outcomes after third molar surgery in patients treated with or without topical minocycline at surgery. PATIENTS AND METHODS: Sixty-three patients at least 18 years of age with all 4 third molars below the occlusal plane were treated with topical minocycline during third molar surgery. Topical minocycline (1.0 mg in bioresorbable polyglycolide-co-dl-lactide [PGLA] sustained-release microspheres) was placed sequentially in bony defects after removal of lower third molars. Clinical and health-related quality of life (HRQOL) outcomes of these patients postsurgery were compared with those of a nonconcurrent control group (n = 60 patients) who did not receive antibiotics. The control group was selected using the same criteria and treated under the same surgical protocol as the antibiotic group. Differences between the groups were assessed with Cochran-Mantel-Haenszel row mean score statistics. RESULTS: The 63 patients in the minocycline group were treated at 4 clinical centers. The incidence of delayed clinical recovery, defined as a postsurgery visit with treatment, was significantly lower in the minocycline group compared with the control group. In the minocycline group, 10% had 1 postsurgery visit with treatment; no patient had 2 visits. In the control group without antibiotics, 28% had at least 1 postsurgery visit with treatment (P = .01) and 13% had at least 2 postsurgery visits with treatment. Recovery time to "no" or "little trouble" with chewing and mouth opening was significantly improved in the minocycline group (P < .05). CONCLUSIONS: Administration of topical minocycline with third molar surgery may improve clinical and HRQOL recovery in healthy adult patients with all 4 third molars below the occlusal plane, a presenting characteristic that has been suggested as a risk factor for delayed recovery. FAU - Stavropoulos, Mary F AU - Stavropoulos MF AD - Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA. FAU - Shugars, Daniel A AU - Shugars DA FAU - Phillips, Ceib AU - Phillips C FAU - Conrad, Shawn M AU - Conrad SM FAU - Fleuchaus, Phillip T AU - Fleuchaus PT FAU - White, Raymond P Jr AU - White RP Jr LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Bacterial Agents) RN - 0 (Anti-Infective Agents, Local) RN - FYY3R43WGO (Minocycline) SB - AIM SB - D SB - IM MH - Administration, Topical MH - Adult MH - Anti-Bacterial Agents/*administration & dosage MH - Anti-Infective Agents, Local/administration & dosage MH - Female MH - Humans MH - Male MH - Minocycline/*administration & dosage MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - *Quality of Life MH - Recovery of Function/drug effects MH - Statistics, Nonparametric MH - Tooth Extraction/*methods MH - Treatment Outcome MH - Wound Healing/drug effects EDAT- 2006/06/20 09:00 MHDA- 2006/07/26 09:00 CRDT- 2006/06/20 09:00 PHST- 2005/03/17 00:00 [received] PHST- 2006/06/20 09:00 [pubmed] PHST- 2006/07/26 09:00 [medline] PHST- 2006/06/20 09:00 [entrez] AID - S0278-2391(06)00381-8 [pii] AID - 10.1016/j.joms.2006.03.007 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2006 Jul;64(7):1059-65. doi: 10.1016/j.joms.2006.03.007. PMID- 32065309 OWN - NLM STAT- MEDLINE DCOM- 20200922 LR - 20200922 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 24 IP - 10 DP - 2020 Oct TI - Bupivacaine vs. lidocaine: a comparison of local anesthetic efficacy in impacted third molar surgery. PG - 3539-3546 LID - 10.1007/s00784-020-03224-5 [doi] AB - OBJECTIVES: The aim of this study was to compare the anesthetic efficacy, the duration of anesthesia, and the postoperative analgesia of lidocaine and bupivacaine and to determine any difference in hemodynamic parameters in patients who required impacted third molar removal. MATERIALS AND METHODS: Thirty-eight patients between the ages of 18 and 40, with no systemic disease, were included in the study, with an indication of impacted lower third molar extraction. One of two local anesthetic agents (Marcaine and Jetokain Simplex) was randomly selected for tooth extractions. The parameters evaluated were the onset of anesthetic agent action, the duration of operation, the duration of postoperative analgesia, and postoperative visual analog scale scores. Hemodynamic parameters were observed and evaluated preoperatively and during the operation. All data were evaluated statistically. RESULTS: When the time of anesthesia onset was analyzed according to both anesthetic solutions, the difference was in favor of lidocaine (p = 0.01). The duration of action was longer in the bupivacaine group than in the lidocaine group (p = 0.00002). VAS values for the pain obtained during injection were lower in the lidocaine group (p = 0.009).However, according to the results of our study, the postoperative analgesic efficacy of bupivacaine is similar to that of lidocaine (p = 0.087). CONCLUSION: After evaluation of these results, we can recommend the use of lidocaine and bupivacaine safely in dentistry practice. But long-duration effect of bupivacaine and the rapid effect of lidocaine may make lidocaine more preferable. CLINICAL RELEVANCE: It is important to determine the clinically effective and safe anesthetic solution. FAU - Velioglu, Ozlem AU - Velioglu O AD - Faculty of Dentistry, Oral Surgery Department, Ege University, Bornova, Izmir, Turkey. FAU - Calis, Aylin Sipahi AU - Calis AS AD - Faculty of Dentistry, Oral Surgery Department, Ege University, Izmir, Turkey. aysipahi@gmail.com. FAU - Koca, Huseyin AU - Koca H AD - Faculty of Dentistry, Oral Surgery Department, Ege University, Izmir, Turkey. FAU - Velioglu, Emre AU - Velioglu E AD - Faculty of Dentistry, Prosthetic Dentistry Department, İzmir Katip Celebi University, Izmır, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200217 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) RN - Y8335394RO (Bupivacaine) SB - D MH - Adolescent MH - Adult MH - *Anesthetics, Local MH - Bupivacaine MH - Double-Blind Method MH - Humans MH - Lidocaine MH - Molar, Third MH - Pain, Postoperative MH - *Tooth, Impacted MH - Young Adult OTO - NOTNLM OT - Bupivacaine OT - Impacted lower third molar removal OT - Lidocaine OT - Local anesthetic EDAT- 2020/02/18 06:00 MHDA- 2020/09/23 06:00 CRDT- 2020/02/18 06:00 PHST- 2019/06/24 00:00 [received] PHST- 2020/01/23 00:00 [accepted] PHST- 2020/02/18 06:00 [pubmed] PHST- 2020/09/23 06:00 [medline] PHST- 2020/02/18 06:00 [entrez] AID - 10.1007/s00784-020-03224-5 [pii] AID - 10.1007/s00784-020-03224-5 [doi] PST - ppublish SO - Clin Oral Investig. 2020 Oct;24(10):3539-3546. doi: 10.1007/s00784-020-03224-5. Epub 2020 Feb 17. PMID- 33223455 OWN - NLM STAT- MEDLINE DCOM- 20210520 LR - 20210520 IS - 2212-4411 (Electronic) VI - 131 IP - 5 DP - 2021 May TI - Can local anesthesia with ropivacaine provide postoperative analgesia in extraction of impacted mandibular third molars? A randomized clinical trial. PG - 512-518 LID - S2212-4403(20)31239-6 [pii] LID - 10.1016/j.oooo.2020.09.010 [doi] AB - OBJECTIVE: The aim of this study was to compare the local anesthesia efficacy of ropivacaine 0.75% compared to lidocaine 2% with 1:100,000 epinephrine for postoperative analgesia following extraction of impacted mandibular third molars. STUDY DESIGN: In this randomized, double-blind crossover clinical trial, 30 participants underwent surgical removal of bilateral impacted mandibular third molars under local anesthesia using ropivacaine 0.75% or lidocaine 2% with 1:100,000 epinephrine. The pain was recorded on a visual analog scale at 4, 8, 12, 24, and 48 h postoperatively. The use of analgesics and the presence of adverse effects were recorded. RESULTS: The duration of soft tissue anesthesia in the ropivacaine group was significantly longer than that in the lidocaine group. The lidocaine group recorded significantly higher visual analog scale scores at all postoperative time intervals, except in the final 48-h period. Analgesic use was higher in the lidocaine group. Rescue medication was used by 2 patients in each group (6.7%). Significantly more postoperative bleeding was seen in the ropivacaine group. CONCLUSION: Ropivacaine 0.75% injection before the surgical procedure may be associated with preventive analgesia for extraction of impacted mandibular third molars. CI - Copyright © 2020 Elsevier Inc. All rights reserved. FAU - Amorim, Klinger de Souza AU - Amorim KS AD - Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, Piracibaba, São Paulo, Brazil. Electronic address: Klinger.amorim@outlook.com. FAU - Gercina, Anne Caroline AU - Gercina AC AD - Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, Piracibaba, São Paulo, Brazil. FAU - Ramiro, Filipe Mazar Santos AU - Ramiro FMS AD - Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, Aracaju, Sergipe, Brazil. FAU - Medeiros, Leonardo de Araújo AU - Medeiros LA AD - Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, Aracaju, Sergipe, Brazil. FAU - de Araújo, Jaiza Samara Macena AU - de Araújo JSM AD - Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, Piracibaba, São Paulo, Brazil. FAU - Groppo, Francisco Carlos AU - Groppo FC AD - Pharmacology, Anesthesiology and Therapeutics Department of the Piracicaba Dental School, University of Campinas, Piracibaba, São Paulo, Brazil. FAU - Souza, Liane Maciel de Almeida AU - Souza LMA AD - Federal University of Sergipe, Oral Surgery and Anesthesiology Area of Dentistry Department, Aracaju, Sergipe, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200930 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anesthetics, Local) RN - 7IO5LYA57N (Ropivacaine) RN - 98PI200987 (Lidocaine) SB - D SB - IM MH - *Analgesia MH - Anesthesia, Local MH - Anesthetics, Local MH - Double-Blind Method MH - Humans MH - Lidocaine MH - *Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - Ropivacaine MH - Tooth Extraction EDAT- 2020/11/24 06:00 MHDA- 2020/11/24 06:00 CRDT- 2020/11/23 05:32 PHST- 2020/03/24 00:00 [received] PHST- 2020/08/02 00:00 [revised] PHST- 2020/09/23 00:00 [accepted] PHST- 2020/11/24 06:00 [pubmed] PHST- 2020/11/24 06:00 [medline] PHST- 2020/11/23 05:32 [entrez] AID - S2212-4403(20)31239-6 [pii] AID - 10.1016/j.oooo.2020.09.010 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 May;131(5):512-518. doi: 10.1016/j.oooo.2020.09.010. Epub 2020 Sep 30. PMID- 19663955 OWN - NLM STAT- MEDLINE DCOM- 20091103 LR - 20181201 IS - 1600-0501 (Electronic) IS - 0905-7161 (Linking) VI - 20 Suppl 4 DP - 2009 Sep TI - What influence do anticoagulants have on oral implant therapy? A systematic review. PG - 96-106 LID - 10.1111/j.1600-0501.2009.01770.x [doi] AB - OBJECTIVES: This systematic review aims to assess the risks (both thromboembolic and bleeding) of an oral anticoagulation therapy (OAT) patient undergoing implant therapy and to provide a management protocol to patients under OAT undergoing implant therapy. MATERIAL AND METHODS: Medline, Cochrane Data Base of Systematic Reviews, the Cochrane Central Register of Controlled Trials and EMBASE (from 1980 to December 2008) were searched for English-language articles published between 1966 and 2008. This search was completed by a hand research accessing the references cited in all identified publications. RESULTS: Nineteen studies were identified reporting outcomes after oral surgery procedures (mostly dental extractions in patients on OAT following different management protocols and haemostatic therapies). Five studies were randomized-controlled trials (RCTs), 11 were controlled clinical trials (CCTs) and three were prospective case series. The OAT management strategies as well as the protocols during and after surgery were different. This heterogeneity prevented any possible data aggregation and synthesis. The results from these studies are very homogeneous, reporting minor bleeding in very few patients, without a significant difference between the OAT patients who continue with the vitamin K antagonists vs. the patients who stopped this medication before surgery. These post-operative bleeding events were controlled only with local haemostatic measures: tranexamic acid mouthwashes, gelatine sponges and cellulose gauzes's application were effective. Post-operative bleeding did not correlate with the international normalised ratio (INR) status. In none of the studies was a thromboembolic event reported. CONCLUSIONS: OAT patients (INR 2-4) who do not discontinue the AC medication do not have a significantly higher risk of post-operative bleeding than non-OAT patients and they also do not have a higher risk of post-operative bleeding than OAT patients who discontinue the medication. In patients with OAT (INR 2-4) without discontinuation, topical haemostatic agents were effective in preventing post-operative bleeding. OAT discontinuation is not recommended for minor oral surgery, such as single tooth extraction or implant placement, provided that this does not involve autogenous bone grafts, extensive flaps or osteotomy preparations extending outside the bony envelope. Evidence does not support that dental implant placement in patients on OAT is contraindicated. FAU - Madrid, Carlos AU - Madrid C AD - Department of oral surgery, Oral Medicine and Hospital Dentistry, Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland. carlos.madrid@hospvd.ch FAU - Sanz, Mariano AU - Sanz M LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - Denmark TA - Clin Oral Implants Res JT - Clinical oral implants research JID - 9105713 RN - 0 (Anticoagulants) RN - 0 (Hemostatics) RN - 0 (Mouthwashes) RN - 5Q7ZVV76EI (Warfarin) RN - 6T84R30KC1 (Tranexamic Acid) RN - 9000-70-8 (Gelatin) SB - D MH - Administration, Oral MH - Administration, Topical MH - Anticoagulants/administration & dosage/*adverse effects MH - Atrial Fibrillation MH - Contraindications MH - Dental Care for Chronically Ill/*methods MH - *Dental Implantation, Endosseous MH - Gelatin/administration & dosage/therapeutic use MH - Heart Valve Prosthesis MH - Hemostatics/administration & dosage MH - Humans MH - International Normalized Ratio MH - Mouthwashes/therapeutic use MH - Oral Surgical Procedures/*adverse effects MH - Postoperative Hemorrhage/drug therapy/*etiology MH - Thromboembolism/etiology/prevention & control MH - Tranexamic Acid/administration & dosage/therapeutic use MH - Venous Thrombosis/prevention & control MH - Warfarin/administration & dosage/*adverse effects RF - 48 EDAT- 2009/08/12 09:00 MHDA- 2009/11/05 06:00 CRDT- 2009/08/12 09:00 PHST- 2009/08/12 09:00 [entrez] PHST- 2009/08/12 09:00 [pubmed] PHST- 2009/11/05 06:00 [medline] AID - CLR1770 [pii] AID - 10.1111/j.1600-0501.2009.01770.x [doi] PST - ppublish SO - Clin Oral Implants Res. 2009 Sep;20 Suppl 4:96-106. doi: 10.1111/j.1600-0501.2009.01770.x. PMID- 21753734 OWN - NLM STAT- MEDLINE DCOM- 20111130 LR - 20110808 IS - 1538-2982 (Electronic) IS - 1056-6163 (Linking) VI - 20 IP - 4 DP - 2011 Aug TI - Ridge preservation of the molar extraction socket using collagen sponge and xenogeneic bone grafts. PG - 267-72 LID - 10.1097/ID.0b013e3182166afc [doi] AB - OBJECTIVE: The purpose of this study was to evaluate the efficacy of the alveolar ridge preservation technique using collagen sponge and xenograft after extraction. STUDY DESIGN: Twenty patients were divided into the control group and the experimental group, which contained about 10 patients each. The control group patients were planned 3-unit bridge without performing implant and without special treatments for the extraction socket, and prosthetic treatments were performed after 3 months. In the experimental group, using collagen sponge and xenogeneic bone graft, alveolar ridge preservation was performed simultaneously with tooth extraction; implants were placed after 3 months. Clinical and histological evaluations and statistical analysis were performed. RESULTS: The resorption rate of the width of alveolar bone 3 mm below the alveolar ridge of the control group was shown to be 20.74% and of the experimental group was an average of 14.26%, approximately a difference of 6% was observed, and it was statistically significant. New bone formation in the vicinity of bone graft materials was achieved well, and inflammation findings were not observed. CONCLUSION: The results indicated that in the ridge preservation using collagen sponge and xenograft, xenograft prevents the horizontal resorption of the alveolar ridge, and the upper collagen sponge blocks the infiltration of soft tissues to the lower area, and thus it has the advantage of the enhancement of bone fill. FAU - Kim, Young-Kyun AU - Kim YK AD - Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seoul, Korea. FAU - Yun, Pil-Young AU - Yun PY FAU - Lee, Hyo-Jung AU - Lee HJ FAU - Ahn, Ji-Yeon AU - Ahn JY FAU - Kim, Su-Gwan AU - Kim SG LA - eng PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Implant Dent JT - Implant dentistry JID - 9206481 RN - 0 (Bio-Oss) RN - 0 (Bone Substitutes) RN - 0 (Minerals) RN - 9007-34-5 (Collagen) SB - D MH - Adult MH - Aged MH - Alveolar Bone Loss/etiology/*prevention & control MH - Bone Matrix/transplantation MH - *Bone Substitutes MH - Collagen MH - Dental Implants, Single-Tooth MH - Denture, Partial, Fixed MH - Female MH - Humans MH - Male MH - Middle Aged MH - Minerals MH - Molar/surgery MH - Statistics, Nonparametric MH - Tooth Extraction/*adverse effects MH - Tooth Socket/*surgery EDAT- 2011/07/15 06:00 MHDA- 2011/12/13 00:00 CRDT- 2011/07/15 06:00 PHST- 2011/07/15 06:00 [entrez] PHST- 2011/07/15 06:00 [pubmed] PHST- 2011/12/13 00:00 [medline] AID - 10.1097/ID.0b013e3182166afc [doi] PST - ppublish SO - Implant Dent. 2011 Aug;20(4):267-72. doi: 10.1097/ID.0b013e3182166afc. PMID- 32862256 OWN - NLM STAT- MEDLINE DCOM- 20210518 LR - 20210519 IS - 1865-1569 (Electronic) IS - 1865-1550 (Print) IS - 1865-1550 (Linking) VI - 25 IP - 2 DP - 2021 Jun TI - Alveolar iodine tampon packing after impacted third molar surgery improves oral health-related quality of life and postoperative sequela: a randomized study. PG - 181-190 LID - 10.1007/s10006-020-00898-9 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the effect of an iodine tampon on postoperative discomfort after surgical removal of a mandibular third molar. MATERIAL AND METHODS: Patients were randomly assigned to two groups: one group received an alveolar iodine-containing tampon in the extraction socket (N = 44), and the other group used a disposable syringe (Monoject®) to rinse the wound (N = 43). Postoperative discomfort was assessed with the Oral Health Impact Profile-14 (OHIP-14) questionnaire, Pain Intensity Numerical Rating Scale (PI-NRS), and questions about self-care and discomfort. RESULTS: This study included 87 patients (52 women and 35 men) with an average age of 26.47 years (SD, 6.36). The mean OHIP-14 sum scores were significantly lower in the iodine tampon group compared with the Monoject® syringe group. Mean PI-NRS scores significantly differed between the iodine tampon group (3.33; SE, 0.27) and Monoject® syringe group (4.46; SE, 0.27) (F (1, 85) = 8.16, p < 0.01), with no interaction effect between time and PI-NRS (F (6, 510) = 1.26, p = 0.28). Patients in the iodine tampon group reported less postoperative discomfort. CONCLUSIONS: Insertion of an iodine-containing tampon in the postoperative socket reduced the pain and impact on oral health-related quality of life during the first postoperative week and positively influenced postoperative sequelae. FAU - Lindeboom, Jerome A AU - Lindeboom JA AUID- ORCID: 0000-0001-8249-3774 AD - Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands. j.a.lindeboom@amc.uva.nl. AD - Department of Oral and Maxillofacial Surgery, Amstelland Hospital, Amstelveen, The Netherlands. j.a.lindeboom@amc.uva.nl. FAU - Tuk, Jacco G AU - Tuk JG AD - Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands. AD - Department of Oral and Maxillofacial Surgery, Amstelland Hospital, Amstelveen, The Netherlands. FAU - Möllenkamp, Patrick AU - Möllenkamp P AD - Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands. FAU - van Wijk, Arjen J AU - van Wijk AJ AD - Department of Social Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200829 TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 9679TC07X4 (Iodine) SB - D SB - IM MH - Adult MH - Female MH - Humans MH - *Iodine MH - Male MH - Mandible MH - Molar, Third/surgery MH - Pain, Postoperative/etiology/prevention & control MH - Quality of Life MH - Tooth Extraction MH - *Tooth, Impacted/surgery PMC - PMC8121736 OTO - NOTNLM OT - Alveolar packing OT - OHRQoL OT - Pain OT - Third molars COIS- The authors declare that they have no conflict of interest. EDAT- 2020/08/31 06:00 MHDA- 2021/05/19 06:00 CRDT- 2020/08/31 06:00 PHST- 2020/05/12 00:00 [received] PHST- 2020/08/18 00:00 [accepted] PHST- 2020/08/31 06:00 [pubmed] PHST- 2021/05/19 06:00 [medline] PHST- 2020/08/31 06:00 [entrez] AID - 10.1007/s10006-020-00898-9 [pii] AID - 898 [pii] AID - 10.1007/s10006-020-00898-9 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2021 Jun;25(2):181-190. doi: 10.1007/s10006-020-00898-9. Epub 2020 Aug 29. PMID- 28294694 OWN - NLM STAT- MEDLINE DCOM- 20180913 LR - 20180913 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 35 IP - 8 DP - 2017 Aug TI - The Effects of Transcutaneous and Intraoral Low-Level Laser Therapy After Extraction of Lower Third Molars: A Randomized Single Blind, Placebo Controlled Dual-Center Study. PG - 401-407 LID - 10.1089/pho.2016.4252 [doi] AB - OBJECTIVE AND BACKGROUND: The surgical removal of impacted third molars is one of the most common procedures performed by oral and maxillofacial surgeons. The purpose of this study is to determine whether either transcutaneous or intraoral low-level laser therapy (LLLT) reduces postoperative pain and assists in the healing of mandibular third molar extraction. MATERIALS AND METHODS: This randomized, placebo controlled, single-blind, split-mouth design study was conducted on 60 patients with full bony impacted similar position mandibular third molars bilaterally. The patients were divided into two groups of 30 each: transcutaneous LLLT and intraoral LLLT and the other side of each group treated with nonactive laser (60 teeth). The laser treatment consisted of administering laser energy immediately before and after the extraction procedure with gallium aluminum arsenide (GaAlAs) 830 nm diode lasers. Postoperative pain and healing of the sockets were compared in transcutaneous and intraoral group with placebo for 1 week following the extraction. Descriptive and bivariate statistics was computed, and the p-value was set at 0.05. RESULTS: Intraoral LLLT application resulted in a statistically significant reduction of postoperative pain in comparison with transcutaneous laser group and placebo. The unhealed socket numbers were compared in two groups at seventh day and no differences were observed. CONCLUSIONS: The results of this study suggest that single-session intraoral LLLT is more effective than extraoral application for reducing postoperative pain. It was postulated that the differences between skin and mucosa could have effect on the results. Although intraoral use would allow closer application to the surgical site, the size of some laser devices precludes their use intraorally. FAU - Kahraman, Sevil Altundag AU - Kahraman SA AD - 1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University , Ankara, Türkiye . FAU - Cetiner, Sedat AU - Cetiner S AD - 1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University , Ankara, Türkiye . FAU - Strauss, Robert A AU - Strauss RA AD - 2 Department of Oral and Maxillofacial Surgery, Virginia Commonwealth University Medical Center , Richmond, Virginia. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20170314 PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 SB - IM MH - Adult MH - Female MH - Humans MH - Low-Level Light Therapy/*methods MH - Male MH - Mandible/radiation effects/*surgery MH - Molar, Third/*surgery MH - Mouth/radiation effects MH - Pain, Postoperative/*radiotherapy MH - Reference Values MH - Risk Factors MH - Single-Blind Method MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects/methods MH - Treatment Outcome MH - Wound Healing/physiology/*radiation effects OTO - NOTNLM OT - LLLT OT - intraoral application OT - pain OT - third molar surgery OT - wound healing EDAT- 2017/03/16 06:00 MHDA- 2018/09/14 06:00 CRDT- 2017/03/16 06:00 PHST- 2017/03/16 06:00 [pubmed] PHST- 2018/09/14 06:00 [medline] PHST- 2017/03/16 06:00 [entrez] AID - 10.1089/pho.2016.4252 [doi] PST - ppublish SO - Photomed Laser Surg. 2017 Aug;35(8):401-407. doi: 10.1089/pho.2016.4252. Epub 2017 Mar 14. PMID- 22971742 OWN - NLM STAT- MEDLINE DCOM- 20140519 LR - 20181113 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 17 IP - 3 DP - 2013 Sep TI - Analgesic efficacy and clinical acceptability of adjunct pre-emptive intravenous tramadol in midazolam sedation for third molar surgery. PG - 193-9 LID - 10.1007/s10006-012-0359-0 [doi] AB - INTRODUCTION: This study aims to compare two routine procedures of sedation, with and without intravenous adjunct analgesia, in third molar surgery regarding postoperative pain and consumption of analgesics. MATERIAL AND METHODS: In a randomized, controlled, single-blinded procedure, 87 men and women aged 18-44 years were divided into two treatment groups, midazolam + tramadol (M + T) and midazolam + saline (M + S), and one control group (C), with no additional medication. After removal of a third lower molar, patients recorded postoperative pain on a visual analog scale (VAS) and consumption of analgesics during the first day after surgery. RESULTS: Time from the end of operation until first rescue pill (400 mg Ibuprofen tablet) differed significantly between the M + S group (193 min) and the C group (110 min) (p = 0.001) as well as the M + T group (157 min) and the C group (p = 0.049). The study did not show any significant reduction of postoperative pain, VAS, after third molar surgery in patients who received adjunct pre-emptive intravenous administration of 1 mg/kg tramadol under midazolam sedation. DISCUSSION AND CONCLUSION: The lack of significant difference between the study and placebo groups indicates that tramadol at 1 mg/kg might be an insufficient dose, though the suitability for tramadol in oral and maxillofacial surgery has already been settled in other studies. FAU - Eriksson, Lars AU - Eriksson L AD - Department of Oral and Maxillofacial Surgery, County Hospital, Falu Lasarett, Sweden. lars.b.eriksson@ltdalarna.se FAU - Tegelberg, Ake AU - Tegelberg A LA - eng PT - Comparative Study PT - Historical Article PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120913 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Analgesics, Opioid) RN - 0 (Hypnotics and Sedatives) RN - 39J1LGJ30J (Tramadol) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Analgesics, Opioid/*administration & dosage MH - *Conscious Sedation MH - History, 15th Century MH - History, 16th Century MH - Humans MH - *Hypnotics and Sedatives MH - Infusions, Intravenous MH - Male MH - *Midazolam MH - Molar, Third/*surgery MH - Pain Measurement/*drug effects MH - Pain, Postoperative/*prevention & control MH - Preanesthetic Medication MH - Single-Blind Method MH - Tooth Extraction/*psychology MH - Tramadol/*administration & dosage MH - Treatment Outcome EDAT- 2012/09/14 06:00 MHDA- 2014/05/20 06:00 CRDT- 2012/09/14 06:00 PHST- 2012/04/10 00:00 [received] PHST- 2012/08/18 00:00 [accepted] PHST- 2012/09/14 06:00 [entrez] PHST- 2012/09/14 06:00 [pubmed] PHST- 2014/05/20 06:00 [medline] AID - 10.1007/s10006-012-0359-0 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2013 Sep;17(3):193-9. doi: 10.1007/s10006-012-0359-0. Epub 2012 Sep 13. PMID- 26469902 OWN - NLM STAT- MEDLINE DCOM- 20160126 LR - 20210109 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 94 IP - 41 DP - 2015 Oct TI - Piezoelectric Versus Conventional Rotary Techniques for Impacted Third Molar Extraction: A Meta-analysis of Randomized Controlled Trials. PG - e1685 LID - 10.1097/MD.0000000000001685 [doi] LID - e1685 AB - Impacted third molars are frequently encountered in clinical work. Surgical removal of impacted third molars is often required to prevent clinical symptoms. Traditional rotary cutting instruments are potentially injurious, and piezosurgery, as a new osteotomy technique, has been introduced in oral and maxillofacial surgery. No consistent conclusion has been reached regarding whether this new technique is associated with fewer or less severe postoperative sequelae after third molar extraction.The aim of this study was to compare piezosurgery with rotary osteotomy techniques, with regard to surgery time and the severity of postoperative sequelae, including pain, swelling, and trismus.We conducted a systematic literature search in the Cochrane Library, PubMed, Embase, and Google Scholar.The eligibility criteria of this study included the following: the patients were clearly diagnosed as having impacted mandibular third molars; the patients underwent piezosurgery osteotomy, and in the control group rotary osteotomy techniques, for removing impacted third molars; the outcomes of interest include surgery time, trismus, swelling or pain; the studies are randomized controlled trials.We used random-effects models to calculate the difference in the outcomes, and the corresponding 95% confidence interval. We calculated the weighted mean difference if the trials used the same measurement, and a standardized mean difference if otherwise.A total of seven studies met the eligibility criteria and were included in our analysis. Compared with rotary osteotomy, patients undergoing piezosurgery experienced longer surgery time (mean difference 4.13 minutes, 95% confidence interval 2.75-5.52, P < 0.0001). Patients receiving the piezoelectric technique had less swelling at postoperative days 1, 3, 5, and 7 (all Ps ≤0.023). Additionally, there was a trend of less postoperative pain and trismus in the piezosurgery groups.The number of included randomized controlled trials and the sample size of each trial were relatively small, double blinding was not possible, and cost analysis was unavailable due to a lack of data.Our meta-analysis indicates that although patients undergoing piezosurgery experienced longer surgery time, they had less postoperative swelling, indicating that piezosurgery is a promising alternative technique for extraction of impacted third molars. FAU - Jiang, Qian AU - Jiang Q AD - From the Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (QJ, YQ, CY, MC, ZZ); Rush Alzheimer's Disease Center (JY); and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois (JY). FAU - Qiu, Yating AU - Qiu Y FAU - Yang, Chi AU - Yang C FAU - Yang, Jingyun AU - Yang J FAU - Chen, Minjie AU - Chen M FAU - Zhang, Zhiyuan AU - Zhang Z LA - eng GR - R01 AG036042/AG/NIA NIH HHS/United States GR - R01AG036042/AG/NIA NIH HHS/United States PT - Journal Article PT - Meta-Analysis PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - AIM SB - IM MH - Humans MH - Molar, Third MH - Operative Time MH - Osteotomy/*methods MH - Pain, Postoperative/epidemiology MH - Piezosurgery/*methods MH - Postoperative Complications/epidemiology MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Trismus/epidemiology PMC - PMC4616780 COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2015/10/16 06:00 MHDA- 2016/01/27 06:00 CRDT- 2015/10/16 06:00 PHST- 2015/10/16 06:00 [entrez] PHST- 2015/10/16 06:00 [pubmed] PHST- 2016/01/27 06:00 [medline] AID - 00005792-201510020-00014 [pii] AID - 10.1097/MD.0000000000001685 [doi] PST - ppublish SO - Medicine (Baltimore). 2015 Oct;94(41):e1685. doi: 10.1097/MD.0000000000001685. PMID- 28732220 OWN - NLM STAT- MEDLINE DCOM- 20190425 LR - 20190425 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 76 IP - 2 DP - 2018 Feb TI - Short-Term Evaluation of Gustatory Changes After Surgical Removal of Mandibular Third Molar-A Prospective Randomized Control Trial. PG - 258-266 LID - S0278-2391(17)30727-9 [pii] LID - 10.1016/j.joms.2017.06.028 [doi] AB - PURPOSE: The present study was carried out to prospectively determine the incidence and severity of suprathreshold taste changes after surgical removal of mandibular third molars. MATERIALS AND METHODS: Sixty patients who required removal of impacted third molars were included in the study. Based on the Winter criteria of angulation of impacted mandibular third molars, 15 patients each with mesioangular, distoangular, horizontal, and vertical impacted third molars were selected. The chemo-gustometry chart in pentagon scheme was used to represent the results of gustometry and to establish a correlation between the difficulty index of impacted third molar removal and the incidence of gustatory changes. All patients underwent spatial taste testing preoperatively and 1 week postoperatively. RESULTS: The highest incidence of taste changes was noted in category 3 (difficulty score, 7 to 8) and mostly for distoangular and vertically impacted teeth. CONCLUSION: In their extensive patient analysis of 4 different taste sensations, the authors found that suprathreshold taste changes do occur after surgical removal of an impacted mandibular third molar, with a high difficulty index score indicating the highest prevalence for altered taste sensations for distoangular and vertical impactions. CI - Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Anand, Rahul AU - Anand R AD - Consultant and private practitioner, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India. FAU - Shankar, Dhayasankar Prabhu AU - Shankar DP AD - Reader, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India. FAU - Manodh, Pedamally AU - Manodh P AD - Professor, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India. FAU - Devadoss, Pradeep AU - Devadoss P AD - Professor, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India. FAU - Aparna, Murugan AU - Aparna M AD - Consultant, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India. Electronic address: aparnamurugan2015@gmail.com. FAU - Neelakandan, Ravana Sundaram AU - Neelakandan RS AD - Professor and Head Of the Department, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170630 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Incidence MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Postoperative Complications/epidemiology MH - Prospective Studies MH - Taste Disorders/*epidemiology MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2017/07/22 06:00 MHDA- 2019/04/26 06:00 CRDT- 2017/07/22 06:00 PHST- 2016/09/05 00:00 [received] PHST- 2017/06/22 00:00 [revised] PHST- 2017/06/22 00:00 [accepted] PHST- 2017/07/22 06:00 [pubmed] PHST- 2019/04/26 06:00 [medline] PHST- 2017/07/22 06:00 [entrez] AID - S0278-2391(17)30727-9 [pii] AID - 10.1016/j.joms.2017.06.028 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2018 Feb;76(2):258-266. doi: 10.1016/j.joms.2017.06.028. Epub 2017 Jun 30. PMID- 22696337 OWN - NLM STAT- MEDLINE DCOM- 20120813 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 6 DP - 2012 Jun 13 TI - Surgical removal versus retention for the management of asymptomatic impacted wisdom teeth. PG - CD003879 LID - 10.1002/14651858.CD003879.pub3 [doi] AB - BACKGROUND: The prophylactic removal of asymptomatic impacted wisdom teeth is defined as the (surgical) removal of wisdom teeth in the absence of local disease. Impacted wisdom teeth may be associated with pathological changes, such as inflammation of the gums around the tooth, root resorption, gum and alveolar bone disease, damage to the adjacent teeth and the development of cysts and tumours. Other reasons to justify prophylactic removal have been to prevent late incisor crowding. When surgical removal is carried out in older patients, following the development of symptoms, the risk of postoperative complications, pain and discomfort increases. Nevertheless, in most developed countries prophylactic removal of trouble-free wisdom teeth, either impacted or fully erupted, has long been considered as 'appropriate care' and is a very common procedure. There is a need to determine whether there is evidence to support this practice. OBJECTIVES: To evaluate the effects of prophylactic removal of asymptomatic impacted wisdom teeth in adolescents and adults compared with the retention (conservative management) of these wisdom teeth. SEARCH METHODS: The following electronic databases were searched: the Cochrane Oral Health Group's Trials Register (to 30 March 2012), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 1), MEDLINE via OVID (1950 to 30 March 2012), and EMBASE via OVID (1980 to 30 March 2012). There were no restrictions on language or date of publication. SELECTION CRITERIA: All randomised controlled trials (RCTs) on adolescents and adults comparing the effect of prophylactic removal of asymptomatic impacted wisdom teeth with no-treatment (retention). DATA COLLECTION AND ANALYSIS: Six review authors screened the results of the search and assessed whether trials met the inclusion criteria for the review. Data extraction and risk of bias assessment were conducted in duplicate and independently by six review authors. Where information was unclear, authors of studies were contacted for additional information. MAIN RESULTS: No RCTs were identified that compared the removal of asymptomatic wisdom teeth with retention and reported quality of life. One RCT on adolescents was identified that compared the removal of impacted mandibular wisdom teeth with retention and only examined the effect on late lower incisor crowding. This study at high risk of bias provided no evidence that extraction of wisdom teeth had an effect on lower incisor crowding over 5 years. AUTHORS' CONCLUSIONS: Insufficient evidence was found to support or refute routine prophylactic removal of asymptomatic impacted wisdom teeth in adults. A single trial comparing removal versus retention found no evidence of a difference on late lower incisor crowding at 5 years, however no other relevant outcomes were measured.Watchful monitoring of asymptomatic third molar teeth may be a more prudent strategy. FAU - Mettes, Theodorus Dirk G AU - Mettes TD AD - Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands. d.mettes@dent.umcn.nl. FAU - Ghaeminia, Hossein AU - Ghaeminia H FAU - Nienhuijs, Marloes E L AU - Nienhuijs ME FAU - Perry, John AU - Perry J FAU - van der Sanden, Wil J M AU - van der Sanden WJ FAU - Plasschaert, Alphons AU - Plasschaert A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20120613 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2005;(2):CD003879. PMID: 15846686 UIN - Cochrane Database Syst Rev. 2016;8:CD003879. PMID: 27578151 MH - Adolescent MH - Humans MH - Molar, Third/*surgery MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2012/06/15 06:00 MHDA- 2012/08/14 06:00 CRDT- 2012/06/15 06:00 PHST- 2012/06/15 06:00 [entrez] PHST- 2012/06/15 06:00 [pubmed] PHST- 2012/08/14 06:00 [medline] AID - 10.1002/14651858.CD003879.pub3 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2012 Jun 13;(6):CD003879. doi: 10.1002/14651858.CD003879.pub3. PMID- 16808181 OWN - NLM STAT- MEDLINE DCOM- 20060816 LR - 20181201 IS - 1029-4864 (Print) IS - 1029-4864 (Linking) VI - 61 IP - 4 DP - 2006 May TI - Post-operative sequelae of lower third molar removal: a literature review and pilot study on the effect of Covomycin D. PG - 154-9 AB - Pain, swelling and dry socket formation commonly follow third molar surgery. The objective was to investigate the effect of intrasocket Covomycin D, an antibiotic/anti-inflammatory medication, on pain, swelling and dry socket following lower third molar removal. Nineteen subjects had bilateral lower third molars removed. The patients were blinded to the side of medication; the opposite side acted as the control; post-operatively a pain visual analogue scale was completed, the side of the worst swelling and the incidence of dry socket noted. The data was analysed using the Wilcoxons matched pairs signed ranks test. Results showed that the pain score was lower for the medicated side in 11 patients on day one and in 16 patients over the six day post-operative period (p < 0.6). The swelling was less on the medicated side in fourteen patients. Three dry sockets developed in non-medicated sockets. In conclusion this study shows that the use of intra-socket Covomycin D favourably influences post-operative sequelae following lower third molar removal. FAU - van Eeden, S P AU - van Eeden SP AD - John Radcliffe Hospital, Headley Way, Headington, Oxford, UK. vandocs@doctors.net.uk FAU - Bütow, K AU - Bütow K LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Review PL - South Africa TA - SADJ JT - SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging JID - 9812497 RN - 0 (Anti-Bacterial Agents) RN - 0 (Drug Combinations) RN - 0 (Glucocorticoids) RN - 0 (chloramphenicol, dexamethasone, neomycin drug combination) RN - 66974FR9Q1 (Chloramphenicol) RN - 7S5I7G3JQL (Dexamethasone) RN - I16QD7X297 (Neomycin) SB - D MH - Administration, Topical MH - Adolescent MH - Adult MH - Anti-Bacterial Agents/administration & dosage/*therapeutic use MH - Chloramphenicol/administration & dosage/*therapeutic use MH - Dexamethasone/administration & dosage/*therapeutic use MH - Drug Combinations MH - Dry Socket/etiology/*prevention & control MH - Edema/etiology/prevention & control MH - Glucocorticoids/administration & dosage/*therapeutic use MH - Humans MH - Molar, Third/*surgery MH - Neomycin/administration & dosage/*therapeutic use MH - Pain, Postoperative/etiology/*prevention & control MH - Pilot Projects MH - Single-Blind Method MH - Statistics, Nonparametric MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Treatment Outcome RF - 6 EDAT- 2006/07/01 09:00 MHDA- 2006/08/17 09:00 CRDT- 2006/07/01 09:00 PHST- 2006/07/01 09:00 [pubmed] PHST- 2006/08/17 09:00 [medline] PHST- 2006/07/01 09:00 [entrez] PST - ppublish SO - SADJ. 2006 May;61(4):154-9. PMID- 29465055 OWN - NLM STAT- MEDLINE DCOM- 20180723 LR - 20181202 IS - 1119-3077 (Print) VI - 21 IP - 2 DP - 2018 Feb TI - Evaluation of the Effect of Platelet-Rich Fibrin on the Alveolar Osteitis Incidence and Periodontal Probing Depth after Extracting Partially Erupted Mandibular Third Molars Extraction. PG - 201-205 LID - 10.4103/njcp.njcp_1_17 [doi] AB - AIMS: To evaluate whether the alveolar osteitis (AO) incidence after extracting partially erupted third molars differs when platelet-rich fibrin (PRF) is administered in the alveolar socket and to assess the influence of PRF on postoperative pain levels and periodontal probing depth. SETTINGS AND DESIGN: In this split-mouth randomized study, 50 patients (17 men/ 33 women; mean age, 23.96 years) with bilateral symmetric partially erupted mandibular third molars were enrolled. MATERIAL AND METHODS: PRF was randomly placed in one extraction socket, whereas the other socket was left empty. A verbal rating scale was used to evaluate postoperative pain levels. AO development was evaluated on the 7th postoperative day. At 3 months postoperatively, periodontal probing depth was measured on the distal surface of the second molars. RESULTS: In total, 8% of patients in the PRF group and 18% of the patients in the control group were diagnosed with AO. None of the smokers in the PRF group and 37.5% smokers in the control group were diagnosed with AO. Mean postoperative pain levels were lower in the PRF group than in the control group at all time points. At 3 months postoperatively, periodontal probing depths were found to be ≤3 mm in both groups. CONCLUSIONS: PRF significantly reduced the AO incidence among smokers and had a positive effect on postoperative pain levels but not on periodontal healing. FAU - Unsal, H AU - Unsal H AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey. FAU - H Erbasar, G N AU - H Erbasar GN AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara Yildirim Beyazit University, Ankara, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 RN - 0 (Fibrin Tissue Adhesive) SB - IM MH - Adolescent MH - Adult MH - Dry Socket/*therapy MH - Female MH - Fibrin Tissue Adhesive/*administration & dosage MH - Humans MH - Incidence MH - Male MH - Molar, Third/*surgery MH - *Platelet-Rich Fibrin MH - Postoperative Complications/epidemiology/*therapy MH - Retrospective Studies MH - Tooth Extraction/*methods MH - Turkey/epidemiology MH - Wound Healing/*physiology MH - Young Adult OTO - NOTNLM OT - Alveolar osteitis OT - mandibular third molar OT - platelet-rich fibrin OT - probing depth COIS- There are no conflicts of interest. EDAT- 2018/02/22 06:00 MHDA- 2018/07/24 06:00 CRDT- 2018/02/22 06:00 PHST- 2018/02/22 06:00 [entrez] PHST- 2018/02/22 06:00 [pubmed] PHST- 2018/07/24 06:00 [medline] AID - NigerJClinPract_2018_21_2_201_225932 [pii] AID - 10.4103/njcp.njcp_1_17 [doi] PST - ppublish SO - Niger J Clin Pract. 2018 Feb;21(2):201-205. doi: 10.4103/njcp.njcp_1_17. PMID- 29316445 OWN - NLM STAT- MEDLINE DCOM- 20190716 LR - 20190716 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 76 IP - 5 DP - 2018 May TI - Does Intra-Alveolar Application of Chlorhexidine Gel in Combination With Platelet-Rich Fibrin Have an Advantage Over Application of Platelet-Rich Fibrin in Decreasing Alveolar Osteitis After Mandibular Third Molar Surgery? A Double-Blinded Randomized Clinical Trial. PG - 939.e1-939.e7 LID - S0278-2391(17)31532-X [pii] LID - 10.1016/j.joms.2017.12.009 [doi] AB - PURPOSE: To evaluate the effectiveness of chlorhexidine (CHX) gel and platelet-rich fibrin (PRF) compared with PRF alone in preventing the development of alveolar osteitis (AO). MATERIALS AND METHODS: In a double-blinded trial, patients undergoing surgical management of bilateral impacted mandibular third molars were randomly divided into 2 groups; 1 group received PRF in 1 extraction socket with the other socket as its control and the other group received 0.2% CHX gel plus PRF in 1 socket with the other socket serving as its control. The study and control sides were unknown to the surgeon and the patient. The predictor variables were PRF application (PRF vs non-PRF) and PRF plus CHX application (PRF-CHX vs non-PRF-CHX). The outcome variable was the development of AO during the first week after surgery. Age, gender, surgical difficulty score, surgeon's experience, number of anesthesia cartridges injected, and irrigation volume were other variables. Data were analyzed in SPSS 11.5 using the t test and χ(2) test, with the confidence interval set at 95%. RESULTS: In total, 482 surgeries were performed on 241 patients (mean age, 24 yr). The overall frequencies of AO in all surgeries, the PRF group, and the PRF-CHX group were 15.14, 17.37, and 13%, respectively. The frequency of AO in the PRF and PRF-CHX sockets was significantly lower than in the non-PRF (relative risk = 0.46) and non-PRF-CHX (relative risk = 0.18) sockets, respectively (P < .05). Moreover, the risk of developing AO in the PRF-CHX sockets was significantly lower than in the PRF sockets (relative risk = 0.37; P < .05). CONCLUSION: According to the present findings, the application of CHX gel with PRF increases the efficiency of PRF in lowering the risk of developing AO after surgical removal of impacted mandibular third molars. CI - Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Eshghpour, Majid AU - Eshghpour M AD - Associate Professor, Oral and Maxillofacial Department, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Danaeifar, Nasrin AU - Danaeifar N AD - General Dentist, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Kermani, Hamed AU - Kermani H AD - Assistant Professor, Oral and Maxillofacial Department, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Nejat, Amir Hossein AU - Nejat AH AD - Resident, Prosthodontics Department, Louisiana State University, New Orleans, LA. Electronic address: amir.h.nejat@outlook.com. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20171216 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Gels) RN - R4KO0DY52L (Chlorhexidine) SB - AIM SB - D SB - IM MH - Administration, Topical MH - Adult MH - Anti-Infective Agents, Local/*therapeutic use MH - Chlorhexidine/*therapeutic use MH - Combined Modality Therapy MH - Double-Blind Method MH - Dry Socket/etiology/*prevention & control MH - Female MH - Follow-Up Studies MH - Gels MH - Humans MH - Male MH - Molar, Third/*surgery MH - *Platelet-Rich Fibrin MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2018/01/10 06:00 MHDA- 2019/07/17 06:00 CRDT- 2018/01/10 06:00 PHST- 2016/11/20 00:00 [received] PHST- 2017/12/08 00:00 [revised] PHST- 2017/12/08 00:00 [accepted] PHST- 2018/01/10 06:00 [pubmed] PHST- 2019/07/17 06:00 [medline] PHST- 2018/01/10 06:00 [entrez] AID - S0278-2391(17)31532-X [pii] AID - 10.1016/j.joms.2017.12.009 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2018 May;76(5):939.e1-939.e7. doi: 10.1016/j.joms.2017.12.009. Epub 2017 Dec 16. PMID- 26609696 OWN - NLM STAT- MEDLINE DCOM- 20171010 LR - 20181202 IS - 1943-3670 (Electronic) IS - 0022-3492 (Linking) VI - 87 IP - 3 DP - 2016 Mar TI - Effect of Surgical Intervention for Removal of Mandibular Third Molar on Periodontal Healing of Adjacent Mandibular Second Molar: A Systematic Review and Bayesian Network Meta-Analysis. PG - 291-302 LID - 10.1902/jop.2015.150363 [doi] AB - BACKGROUND: The aim of this systematic review is to evaluate and synthesize scientific evidence on the effect of surgical interventions for removal of mandibular third molar (M3M) on periodontal healing of adjacent mandibular second molar (M2M). METHODS: The protocol was registered at PROSPERO (International Prospective Register of Systematic Reviews) as CRD42012003059. Medline, Cochrane, and EMBASE databases were interrogated to identify randomized controlled trials (RCTs) up to December 22, 2014. Patients with M3Ms fully developed, unilaterally or bilaterally impacted, were considered. Outcomes were clinical attachment level gain (CALg) and probing depth reduction (PDr) with a follow-up ≥ 6 months. Patient-subjective outcomes, such as pain, discomfort, and complications, and financial aspects and chair time, were also explored. A Bayesian network meta-analysis model was used to estimate direct and indirect effects and to establish a ranking of treatments. RESULTS: Sixteen RCTs were included and categorized into four groups investigating the following: 1) regenerative/grafting procedures (10 RCTs); 2) flap design (three RCTs); 3) type of suturing (one RCT); and 4) periodontal care of M2M (two RCTs). Guided tissue regeneration (GTR) with resorbable (GTRr) and non-resorbable (GTRnr) membrane and GTRr with anorganic xenograft (GTRr + AX) showed the highest mean ranking for CALg (2.99, 90% credible interval [CrI] = 1 to 5; 2.80, 90% CrI = 1 to 6; and 2.29, 90% CrI = 1 to 6, respectively) and PDr (2.83, 90% CrI = 1 to 5; 2.52, 90% CrI = 1 to 5; and 2.77, 90% CrI = 1 to 6, respectively). GTRr + AX showed the highest probability (Pr) of being the best treatment for CALg (Pr = 45%) and PDr (Pr = 32%). Direct and network quality of evidence were rated from very low to moderate. CONCLUSIONS: To the best of the authors' knowledge, the present review is the first one to evaluate quantitatively and qualitatively the effect of different interventions on periodontal healing distal to the second molar after extraction of the third molar. GTR-based procedures with or without combined grafting therapies provide some adjunctive clinical benefit compared to standard non-regenerative/non-grafting procedures. However, the overall low quality of evidence suggests a low degree of confidence and certainty in treatment effects. Evidence on variations of surgical M3M removal techniques based on flap design, type of suturing, and periodontal care of M2M is limited both qualitatively and quantitatively. FAU - Barbato, Luigi AU - Barbato L AD - Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. FAU - Kalemaj, Zamira AU - Kalemaj Z AD - Department of Surgical Sciences, School of Dentistry, University of Turin, Turin, Italy. FAU - Buti, Jacopo AU - Buti J AD - School of Dentistry, University of Manchester, Manchester, UK. FAU - Baccini, Michela AU - Baccini M AD - Department of Statistics, University of Florence. FAU - La Marca, Michele AU - La Marca M AD - Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. FAU - Duvina, Marco AU - Duvina M AD - Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. FAU - Tonelli, Paolo AU - Tonelli P AD - Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. LA - eng PT - Journal Article PT - Multicenter Study PT - Review PT - Systematic Review DEP - 20151126 PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 SB - D SB - IM MH - Bayes Theorem MH - Humans MH - Molar MH - Molar, Third/*surgery MH - Network Meta-Analysis MH - Periodontium/*injuries MH - Wound Healing OTO - NOTNLM OT - Meta-analysis OT - molar, third OT - periodontal index OT - periodontal pocket OT - randomized controlled trial OT - tooth extraction EDAT- 2015/11/27 06:00 MHDA- 2017/10/11 06:00 CRDT- 2015/11/27 06:00 PHST- 2015/11/27 06:00 [entrez] PHST- 2015/11/27 06:00 [pubmed] PHST- 2017/10/11 06:00 [medline] AID - 10.1902/jop.2015.150363 [doi] PST - ppublish SO - J Periodontol. 2016 Mar;87(3):291-302. doi: 10.1902/jop.2015.150363. Epub 2015 Nov 26. PMID- 15660075 OWN - NLM STAT- MEDLINE DCOM- 20050225 LR - 20141120 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 99 IP - 2 DP - 2005 Feb TI - Preemptive rofecoxib and dexamethasone for prevention of pain and trismus following third molar surgery *. PG - E1-7 AB - Objective The goal of this preliminary randomized prospective clinical trial was to compare the analgesic efficacy and the reduction in trismus of preoperative rofecoxib, intraoperative dexamethasone, and both rofecoxib and dexamethasone following third molar extraction surgery. Study design Thirty-five subjects requiring surgical removal of at least 1 partial bony impacted mandibular third molar were invited to participate in this double-blind and double-dummy placebo-controlled clinical trial. Subjects were randomly assigned into 1 of 4 treatment groups: (1) placebo po preoperatively and placebo IV intraoperatively; (2) rofecoxib 50 mg po preoperatively and placebo IV intraoperatively; (3) placebo po preoperatively and dexamethasone10 mg IV intraoperatively; and (4) rofecoxib 50 mg po preoperatively and dexamethasone 10 mg IV intraoperatively. Subjects completed a diary assessing postoperative pain onset and intensity using categorical and visual analogue scales. Interincisal opening was assessed 1, 2, 3, and 7 days postoperatively using a Therabite ruler. Results This randomized controlled clinical trial enrolled 35 subjects. Two subjects did not meet the inclusion criteria and 4 did not return completed diaries. The mean age of the remaining 29 subjects (11 males, 18 females) was 22.8 years (+/- 0.6 year). The active treatments tended to delay the need for initial pain medication. When compared to other active treatments and to placebo, the combination of preoperative rofecoxib and intraoperative dexamethasone significantly reduced initial pain intensity ( P < .05). Baseline interincisal opening was 52.6 mm (+/- 6.2). The greatest decrease in interincisal opening was 43.3% for the placebo group at 24 hours. Preoperative rofecoxib alone showed a decrease in interincisal opening of 42.3% ( P = ns) at 24 hours. Intraoperative dexamethasone alone showed a decrease in the interincisal opening of 24.1% of baseline ( P < .05 vs placebo). The group receiving the combination of rofecoxib and dexamethasone showed a decrease in interincisal opening of 23.7% of baseline ( P < .05 vs placebo). Conclusions The results of this trial indicate that the use of intraoperative dexamethasone is an effective therapeutic strategy for limiting trismus following surgical removal of impacted third molars. The combination of preoperative rofecoxib 50 mg and intraoperative dexamethasone 10 mg was most effective in minimizing pain and trismus following third molar surgery. FAU - Moore, Paul A AU - Moore PA FAU - Brar, Pardeep AU - Brar P FAU - Smiga, Eric R AU - Smiga ER FAU - Costello, Bernard J AU - Costello BJ LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Lactones) RN - 0 (Sulfones) RN - 0QTW8Z7MCR (rofecoxib) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Dexamethasone/*therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Intraoperative Care MH - Lactones/*therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Preoperative Care MH - Prospective Studies MH - Sulfones/*therapeutic use MH - Trismus/*prevention & control EDAT- 2005/01/22 09:00 MHDA- 2005/06/21 09:00 CRDT- 2005/01/22 09:00 PHST- 2005/01/22 09:00 [pubmed] PHST- 2005/06/21 09:00 [medline] PHST- 2005/01/22 09:00 [entrez] AID - S1079210404006213 [pii] AID - 10.1016/j.tripleo.2004.08.028 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):E1-7. doi: 10.1016/j.tripleo.2004.08.028. PMID- 22732846 OWN - NLM STAT- MEDLINE DCOM- 20130527 LR - 20131121 IS - 2212-4411 (Electronic) VI - 114 IP - 1 DP - 2012 Jul TI - Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. PG - 27-34 LID - 10.1016/j.tripleo.2011.05.027 [doi] AB - OBJECTIVE: Lower third molar removal provides a clinical model for studying analgesic drugs. The present study's aim was to compare the clinical efficacy of sublingual ketorolac and sublingual piroxicam in managing pain, trismus and swelling after lower third molar extraction in adult volunteers. STUDY DESIGN: In this double-blinded, randomized, crossover investigation, 47 volunteers received for 4 days ketorolac sublingually (10 mg 4 times daily) and piroxicam sublingually (20 mg once daily) during 2 separate appointments after lower third molar extraction of symmetrically positioned lower third molars. A surgeon evaluated objective parameters (surgery duration, mouth opening, rescue analgesic medication, and facial swelling) and volunteers documented subjective parameters (postoperative pain and global evaluation), comparing postoperative results for a total of 7 days after surgery. The means of the objective and subjective parameters were compared for statistical significance (P < .05). RESULTS: Volunteers reported low pain scores during the postoperative period when treated with either sublingual ketorolac or piroxicam. Also, volunteers ingested similar amounts of analgesic rescue medication (paracetamol) when they received either drug sublingually (P > .05). Additionally, values for mouth openings measured just before surgery and immediately after suture removal 7 days later were similar among volunteers (P > .05), and the type of nonsteroidal antiinflammatory drug (NSAID) used in this study showed no significant differences between swellings on the second or seventh days after surgery (P > .05). CONCLUSIONS: Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated. CI - Copyright © 2012 Elsevier Inc. All rights reserved. FAU - Trindade, Paulo A K AU - Trindade PA AD - Bauru School of Dentistry, University of São Paulo, Bauru, Brazil. FAU - Giglio, Fernando P M AU - Giglio FP FAU - Colombini-Ishikiriama, Bella L AU - Colombini-Ishikiriama BL FAU - Calvo, Adriana M AU - Calvo AM FAU - Modena, Karin Cristina S AU - Modena KC FAU - Ribeiro, Debora A AU - Ribeiro DA FAU - Dionísio, Thiago J AU - Dionísio TJ FAU - Brozoski, Daniel T AU - Brozoski DT FAU - Lauris, José Roberto P AU - Lauris JR FAU - Faria, Flávio Augusto C AU - Faria FA FAU - Santos, Carlos F AU - Santos CF LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20110826 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Cyclooxygenase Inhibitors) RN - 13T4O6VMAM (Piroxicam) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Analysis of Variance MH - Cross-Over Studies MH - Cyclooxygenase Inhibitors/*administration & dosage MH - Double-Blind Method MH - Edema/*drug therapy/etiology MH - Female MH - Humans MH - Ketorolac/*administration & dosage MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Osteotomy MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*administration & dosage MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/*drug therapy/etiology MH - Young Adult EDAT- 2012/06/27 06:00 MHDA- 2013/05/29 06:00 CRDT- 2012/06/27 06:00 PHST- 2011/03/04 00:00 [received] PHST- 2011/05/20 00:00 [revised] PHST- 2011/05/29 00:00 [accepted] PHST- 2012/06/27 06:00 [entrez] PHST- 2012/06/27 06:00 [pubmed] PHST- 2013/05/29 06:00 [medline] AID - S1079-2104(11)00356-8 [pii] AID - 10.1016/j.tripleo.2011.05.027 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul;114(1):27-34. doi: 10.1016/j.tripleo.2011.05.027. Epub 2011 Aug 26. PMID- 22177808 OWN - NLM STAT- MEDLINE DCOM- 20120522 LR - 20120327 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 70 IP - 4 DP - 2012 Apr TI - Does grafting of third molar extraction sockets enhance periodontal measures in 30- to 35-year-old patients? PG - 757-64 LID - 10.1016/j.joms.2011.09.010 [doi] AB - PURPOSE: This study was designed to evaluate the use of xenograft plus a membrane as grafting material for periodontal osseous defects distal to the mandibular second molar compared with nongrafted extraction sites after removal of impacted mandibular third molars. MATERIALS AND METHODS: We performed a single-blind, randomized, controlled clinical trial, and the sample comprised of subjects at high risk for the development of periodontal osseous defects distal to the second molar after third molar extraction (aged 30-35 years), pre-existing osseous defects distal to the second molar, and horizontal third molar impaction. The predictor variable was the treatment status of the second molar osseous defects. The third molar extraction sites were grafted with an anorganic xenograft plus a membrane. The other sites received a full-thickness flap and extraction of the third molar without placement of the grafting materials. The outcome variables were the change in gingival index, pocket probing depth, and clinical attachment level on the distobuccal aspect of the second molar preoperatively and at 3, 6, 9, and 12 months after surgery. Data were statistically analyzed by multivariate analysis of variance, and the statistical significance was set at P < .05. RESULTS: The study was composed of 28 sites that were selected by use of a split-mouth design for each patient, and this was randomly determined through a biased coin randomization. Twelve months after third molar removal, there was a statistically significant gain in the clinical attachment level and a reduction in the probing pocket depth in the grafted sites compared with the nongrafted sites (P < .001). Moreover, there was a significant difference in the alveolar bone height during the monitoring periods for the grafted sites compared with the nongrafted sites (P < .001). CONCLUSIONS: Grafting of osseous defects distal to mandibular second molars with an anorganic xenograft plus a membrane predictably resulted in a significant reduction in the probing pocket depth, clinical attachment level gain, and bone fill, which suggests that grafting the extraction sites with an anorganic xenograft plus a membrane could prevent periodontal disease in the future. CI - Published by Elsevier Inc. FAU - Hassan, Khalid S AU - Hassan KS AD - Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, University of Dammam, Dammam, Saudi Arabia. hassan.khalid56@yahoo.com FAU - Marei, Hesham F AU - Marei HF FAU - Alagl, Adel S AU - Alagl AS LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20111216 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Bio-Gide) RN - 0 (Bio-Oss) RN - 0 (Bone Substitutes) RN - 0 (Membranes, Artificial) RN - 0 (Minerals) RN - 9007-34-5 (Collagen) SB - AIM SB - D SB - IM MH - Adult MH - Alveolar Bone Loss/classification MH - Alveolar Ridge Augmentation/methods MH - Bone Density/physiology MH - Bone Matrix/*transplantation MH - Bone Substitutes/therapeutic use MH - Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Membranes, Artificial MH - Minerals/therapeutic use MH - Molar, Third/*surgery MH - Osteotomy/methods MH - Periodontal Attachment Loss/classification MH - *Periodontal Index MH - Periodontal Pocket/classification MH - Single-Blind Method MH - Surgical Flaps MH - *Tooth Extraction MH - Tooth Socket/*surgery MH - Transplantation, Heterologous MH - Treatment Outcome EDAT- 2011/12/20 06:00 MHDA- 2012/05/23 06:00 CRDT- 2011/12/20 06:00 PHST- 2011/03/01 00:00 [received] PHST- 2011/08/13 00:00 [revised] PHST- 2011/09/07 00:00 [accepted] PHST- 2011/12/20 06:00 [entrez] PHST- 2011/12/20 06:00 [pubmed] PHST- 2012/05/23 06:00 [medline] AID - S0278-2391(11)01459-5 [pii] AID - 10.1016/j.joms.2011.09.010 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2012 Apr;70(4):757-64. doi: 10.1016/j.joms.2011.09.010. Epub 2011 Dec 16. PMID- 28303642 OWN - NLM STAT- MEDLINE DCOM- 20180730 LR - 20180730 IS - 1600-051X (Electronic) IS - 0303-6979 (Linking) VI - 44 IP - 6 DP - 2017 Jun TI - Efficacy of collagen matrix seal and collagen sponge on ridge preservation in combination with bone allograft: A randomized controlled clinical trial. PG - 649-659 LID - 10.1111/jcpe.12722 [doi] AB - AIM: To test whether the use of collagen matrix seal (CMS) results in similar hard and soft tissue remodelling to that with collagen sponge (CS) used as barriers 4 months following alveolar ridge preservation (ARP), in combination with freeze-dried bone allograft (FDBA). MATERIALS AND METHODS: Twenty-eight patients were randomly assigned to the two groups. Clinical and radiographic measurements were recorded with the same stent at baseline and 4 months for standardization. The flapless technique following a traumatic extraction was used for the two types of barriers. RESULTS: All patients completed the study, 14 in the CMS group and 14 in the CS group. Reduction in coronal ridge width (1.21 mm-14.91% CMS and 1.47 mm-20.40% CS) and vertical buccal bone resorption (0.30 mm CMS and 0.79 mm CS) were not significantly different. A slight increase in buccal gingival thickness at the coronal part was observed in both groups (0.9 mm CMS and 0.5 mm CS). CONCLUSIONS: Collagen matrix seal and CS, when combined with FDBA, significantly minimized ridge resorption in all dimensions and maintained buccal soft tissue thickness in sockets with a buccal plate loss of <2 mm in comparison to previously reported findings recorded after tooth extraction without ARP. CI - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Natto, Zuhair S AU - Natto ZS AUID- ORCID: 0000-0003-2723-0255 AD - Department of Dental Public Health, School of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia. AD - Department of Periodontology, School of Dental Medicine, Tufts University, Boston, MA, USA. FAU - Parashis, Andreas AU - Parashis A AD - Department of Periodontology, School of Dental Medicine, Tufts University, Boston, MA, USA. FAU - Steffensen, Bjorn AU - Steffensen B AD - Department of Periodontology, School of Dental Medicine, Tufts University, Boston, MA, USA. FAU - Ganguly, Rumpa AU - Ganguly R AD - Department of Diagnosis and Health Promotion, School of Dental Medicine, Tufts University, Boston, MA, USA. FAU - Finkelman, Matthew D AU - Finkelman MD AD - Department of Public Health, School of Dental Medicine, Tufts University, Boston, MA, USA. FAU - Jeong, Y Natalie AU - Jeong YN AD - Department of Periodontology, School of Dental Medicine, Tufts University, Boston, MA, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170526 PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 RN - 0 (Dental Implants) RN - 0 (Membranes, Artificial) RN - 9007-34-5 (Collagen) SB - D SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Allografts/surgery MH - Alveolar Bone Loss/therapy MH - Alveolar Process/anatomy & histology/diagnostic imaging/surgery MH - Alveolar Ridge Augmentation/*methods MH - Bone Transplantation/*methods MH - Collagen/*therapeutic use MH - Dental Implants MH - Female MH - Freeze Drying MH - Gingiva/anatomy & histology MH - Humans MH - Incisor MH - Male MH - Membranes, Artificial MH - Middle Aged MH - Tooth Extraction MH - Tooth Socket/diagnostic imaging/pathology/*surgery OTO - NOTNLM OT - alveolar ridge preservation OT - bone allograft OT - collagen matrix OT - collagen sponge OT - extracellular matrix OT - extraction socket EDAT- 2017/03/18 06:00 MHDA- 2018/07/31 06:00 CRDT- 2017/03/18 06:00 PHST- 2017/03/12 00:00 [accepted] PHST- 2017/03/18 06:00 [pubmed] PHST- 2018/07/31 06:00 [medline] PHST- 2017/03/18 06:00 [entrez] AID - 10.1111/jcpe.12722 [doi] PST - ppublish SO - J Clin Periodontol. 2017 Jun;44(6):649-659. doi: 10.1111/jcpe.12722. Epub 2017 May 26. PMID- 30311061 OWN - NLM STAT- MEDLINE DCOM- 20191230 LR - 20200225 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 23 IP - 5 DP - 2019 May TI - Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial. PG - 2443-2453 LID - 10.1007/s00784-018-2690-9 [doi] AB - OBJECTIVES: This study investigated and compared the effectiveness of a phytotherapeutic drug composed of herbal extracts on postsurgical discomfort after mandibular third molar surgery. MATERIALS AND METHODS: Eighty-two patients requiring the surgical removal of a mandibular third molar were randomly assigned to receive placebo (group 1), ibuprofen (group 2), and a phytotherapeutic drug (composed of baicalin, 190 mg; bromelain, 50 mg; escin, 30 mg) (group 3). Drugs were administered after tooth extraction twice a day for 5 days. The primary outcome, pain, was evaluated using a visual analogue scale at 2 h, 6 h, 12 h, 24 h, 48 h, and 7 and 10 days after surgery. The secondary outcomes were the changes in maximum mouth opening and facial contours (mm) between baseline and at 24 h, 72 h, and 7 and 10 days after surgery. RESULTS: Compared to the baseline, all treatments demonstrated an improvement in the primary and secondary outcomes. Moreover, compared to groups 1 and 2, patients in group 3 yielded a significant reduction of the postoperative pain score at 12 h (p < 0.001), 24 h (p = 0.010), and 48 h (p = 0.048) after surgery. The mean reduction of the swelling and trismus was similar between groups. CONCLUSIONS: The results of this study suggest that a postoperative administration of a phytotherapeutic drug was found to be effective in postoperative pain management after the surgical removal of impacted mandibular third molars. CLINICAL RELEVANCE: The phytotherapeutic drug composed of herbal extract determined a decrease in the severity of postoperative pain compared to ibuprofen and placebo. FAU - Isola, Gaetano AU - Isola G AUID- ORCID: 0000-0003-4267-6992 AD - Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, AOU Policlinico "G. Martino", Via C. Valeria 1, 98125, Messina, Italy. gaetanoisola@gmail.com. AD - Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", Via G. Pansini 5, 80131, Naples, Italy. gaetanoisola@gmail.com. FAU - Matarese, Marco AU - Matarese M AD - Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, AOU Policlinico "G. Martino", Via C. Valeria 1, 98125, Messina, Italy. FAU - Ramaglia, Luca AU - Ramaglia L AD - Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", Via G. Pansini 5, 80131, Naples, Italy. FAU - Iorio-Siciliano, Vincenzo AU - Iorio-Siciliano V AD - Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", Via G. Pansini 5, 80131, Naples, Italy. FAU - Cordasco, Giancarlo AU - Cordasco G AD - Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, AOU Policlinico "G. Martino", Via C. Valeria 1, 98125, Messina, Italy. FAU - Matarese, Giovanni AU - Matarese G AD - Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, AOU Policlinico "G. Martino", Via C. Valeria 1, 98125, Messina, Italy. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20181011 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Plant Extracts) SB - D CIN - J Am Dent Assoc. 2019 May;150(5):e50. PMID: 30658722 MH - Adult MH - Double-Blind Method MH - Edema/drug therapy MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Phytotherapy MH - Plant Extracts/*therapeutic use MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/drug therapy MH - Young Adult OTO - NOTNLM OT - Ibuprofen OT - Pain OT - Phytotherapeutic drug OT - Swelling OT - Third molar surgery OT - Trismus EDAT- 2018/10/13 06:00 MHDA- 2019/12/31 06:00 CRDT- 2018/10/13 06:00 PHST- 2018/01/03 00:00 [received] PHST- 2018/10/02 00:00 [accepted] PHST- 2018/10/13 06:00 [pubmed] PHST- 2019/12/31 06:00 [medline] PHST- 2018/10/13 06:00 [entrez] AID - 10.1007/s00784-018-2690-9 [pii] AID - 10.1007/s00784-018-2690-9 [doi] PST - ppublish SO - Clin Oral Investig. 2019 May;23(5):2443-2453. doi: 10.1007/s00784-018-2690-9. Epub 2018 Oct 11. PMID- 26596360 OWN - NLM STAT- MEDLINE DCOM- 20171204 LR - 20181202 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 43 IP - 10 DP - 2015 Dec TI - Clinical relevance of cone beam computed tomography in mandibular third molar removal: A multicentre, randomised, controlled trial. PG - 2158-67 LID - S1010-5182(15)00340-6 [pii] LID - 10.1016/j.jcms.2015.10.009 [doi] AB - PURPOSE: The aims of this study were to investigate the effectiveness of cone beam computed tomography (CBCT) compared to panoramic radiography (PR), prior to mandibular third molar removal, in reducing patient morbidity, and to identify risk factors associated with inferior alveolar nerve (IAN) injury. MATERIAL AND METHODS: This multicentre, randomised, controlled trial was performed at three centres in the Netherlands. Adults with an increased risk for IAN injury, as diagnosed from PR, were included in the study. In one arm of the study, patients underwent an additional CBCT prior to third molar surgery. In a second arm of the study, no additional radiographs were acquired. The primary outcome measure was the number of patient-reported altered sensations 1 week after surgery. As secondary outcome measures, the number of patients with objective IAN injury, with long-term (>6 months) IAN injury, the occurrence of other postoperative complications, the Oral Health Related Quality of Life-14 (OHIP-14) questionnaire responses, postoperative pain (visual analogue scale score), duration of surgery, number of emergency visits, and number of missed days of work or study were scored. RESULTS: A total of 268 patients with 320 mandibular third molars were analysed according to the intention-to-treat principle. The overall incidence of IAN injury 1 week after surgery was 6.3%. No significant differences between CBCT and PR for temporary IAN injury (p = 0.64) and all other secondary outcomes were registered. A lingual position of the mandibular canal (MC) and narrowing, in which the diameter of the MC lumen was decreased at the contact area between the MC and the roots, were significant risk factors for temporary IAN injury. CONCLUSION: Although CBCT is a valuable diagnostic adjunct for identification of an increased risk for IAN injury, the use of CBCT does not translate into a reduction of IAN injury and other postoperative complications, after removal of the complete mandibular third molar. In these selected cases of a high risk for IAN injury, an alternative strategy, such as monitoring or a coronectomy, might be more appropriate. (http://clinicaltrials.gov, NCT02071030). CI - Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Ghaeminia, H AU - Ghaeminia H AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands. Electronic address: hos.ghaeminia@gmail.com. FAU - Gerlach, N L AU - Gerlach NL AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands. Electronic address: niekgerlach@hotmail.com. FAU - Hoppenreijs, Th J M AU - Hoppenreijs TJ AD - Rijnstate Hospital Arnhem, Department of Oral and Maxillofacial Surgery, Wagnerlaan 55, 6815AD Arnhem, The Netherlands. Electronic address: hoppenreijs@me.com. FAU - Kicken, M AU - Kicken M AD - Rijnstate Hospital Arnhem, Department of Oral and Maxillofacial Surgery, Wagnerlaan 55, 6815AD Arnhem, The Netherlands. Electronic address: marc.kicken@gmail.com. FAU - Dings, J P AU - Dings JP AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands. Electronic address: jeroen.dings@radboudumc.nl. FAU - Borstlap, W A AU - Borstlap WA AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands; ZBC Private Clinic Nijmegen, Oral and Maxillofacial Surgery, Groenewoudseweg 315, 6524 TX Nijmegen, The Netherlands. Electronic address: wilfred.borstlap@radboudumc.nl. FAU - de Haan, T AU - de Haan T AD - Radboud University Medical Center, Department of Health Evidence, Geert Grooteplein-Noord 21, 6525 GA Nijmegen, The Netherlands. Electronic address: ton.dehaan@radboudumc.nl. FAU - Bergé, S J AU - Bergé SJ AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands; ZBC Private Clinic Nijmegen, Oral and Maxillofacial Surgery, Groenewoudseweg 315, 6524 TX Nijmegen, The Netherlands. Electronic address: stefaan.berge@radboudumc.nl. FAU - Meijer, G J AU - Meijer GJ AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands; Radboud University Medical Center, Implantology & Periodontology, Phillips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands. Electronic address: gert.meijer@radboudumc.nl. FAU - Maal, T J AU - Maal TJ AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands. Electronic address: thomas.maal@radboudumc.nl. LA - eng SI - ClinicalTrials.gov/NCT02071030 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20151023 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 SB - D SB - IM CIN - Evid Based Dent. 2016 Dec;17 (4):117-118. PMID: 27980326 MH - Cone-Beam Computed Tomography/*methods MH - Humans MH - Molar, Third/*surgery MH - Netherlands MH - Quality of Life MH - Radiography, Panoramic/methods MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Trigeminal Nerve Injuries/epidemiology/etiology/prevention & control OTO - NOTNLM OT - Complications OT - Dry socket OT - Mandibular nerve OT - Panoramic radiography OT - Quality of life OT - Three-dimensional imaging EDAT- 2015/11/26 06:00 MHDA- 2017/12/05 06:00 CRDT- 2015/11/25 06:00 PHST- 2015/05/23 00:00 [received] PHST- 2015/08/31 00:00 [revised] PHST- 2015/10/06 00:00 [accepted] PHST- 2015/11/25 06:00 [entrez] PHST- 2015/11/26 06:00 [pubmed] PHST- 2017/12/05 06:00 [medline] AID - S1010-5182(15)00340-6 [pii] AID - 10.1016/j.jcms.2015.10.009 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2015 Dec;43(10):2158-67. doi: 10.1016/j.jcms.2015.10.009. Epub 2015 Oct 23. PMID- 23923440 OWN - NLM STAT- MEDLINE DCOM- 20131101 LR - 20130807 IS - 0028-2200 (Print) IS - 0028-2200 (Linking) VI - 120 IP - 7-8 DP - 2013 Jul-Aug TI - [Modified polyurethane foam as a local hemostatic agent after dental extractions]. PG - 378-82 AB - In this split mouth experiment, the feasibility ofpolyurethane foam as a local hemostatic agent after dental extractions was studied. Ten healthy patients underwent 2 extractions ofa dental element in 1 treatment session. The 10 patients were subsequently randomly divided in a gelatin group and a collagen group. In the gelatin group, a polyurethane foam (PU) was applied in 1 extraction socket, while in the other socket a commercially available gelatin foam was applied. In the collagen group, a PU was applied in 1 socket, and a collagen wadding in the other. All hemostats were removed after 2 minutes, after which the degree of coagulation was measured using a thrombin/antithrombin test and a fibrinogen test. This study suggests that polyurethane foam has hemostatic capacity. Large scale clinical research is needed to confirm this finding, and should indicate whether this hemostatic capacity is clinically relevant. FAU - Selten, M H A AU - Selten MH AD - Uit de afdeling Kaakchirurgie van het Universitair Medisch Centrum Groningen. m.h.a.selten@umcg.nl FAU - Broekema, F I AU - Broekema FI FAU - Zuidema, J AU - Zuidema J FAU - van Oeveren, W AU - van Oeveren W FAU - Bos, R R M AU - Bos RR LA - dut PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Gemodificeerd polyurethaanschuim als lokaal hemostaticumn na gebitsextracties. PL - Netherlands TA - Ned Tijdschr Tandheelkd JT - Nederlands tijdschrift voor tandheelkunde JID - 0400771 RN - 0 (Hemostatics) RN - 0 (Polyurethanes) SB - D MH - Dry Socket/prevention & control MH - Female MH - Hemostatics/pharmacology/*therapeutic use MH - Humans MH - Male MH - Oral Hemorrhage/etiology/*prevention & control MH - Polyurethanes/pharmacology/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Young Adult EDAT- 2013/08/08 06:00 MHDA- 2013/11/02 06:00 CRDT- 2013/08/08 06:00 PHST- 2013/08/08 06:00 [entrez] PHST- 2013/08/08 06:00 [pubmed] PHST- 2013/11/02 06:00 [medline] PST - ppublish SO - Ned Tijdschr Tandheelkd. 2013 Jul-Aug;120(7-8):378-82. PMID- 22374059 OWN - NLM STAT- MEDLINE DCOM- 20120423 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 70 IP - 3 DP - 2012 Mar TI - Postoperative bleeding after dental extraction in liver pretransplant patients. PG - e177-84 LID - 10.1016/j.joms.2011.10.033 [doi] AB - PURPOSE: The aim of this prospective observational study was to evaluate the incidence of postoperative bleeding after dental extraction in candidates for liver transplantation and the efficacy of the association of tranexamic acid and absorbable hemostatic sponges. PATIENTS AND METHODS: All individuals referred for oral health evaluation requiring extraction were considered in this study. Patients were included in the analysis when the blood examinations showed a platelet count of 30,000/mm(3) or greater and an international normalized ratio (INR) of 3.0 or less. In group 1 local pressure was applied by use of gauze soaked with tranexamic acid, and in group 2 gauze without tranexamic acid was used. Absorbable hemostatic sponges and cross sutures were used as a standard hemostatic measure. RESULTS: In the 23 patients included in this study, 84 simple extractions were performed during 35 dental surgical procedures. The main preoperative blood tests found the following: a mean hematocrit level of 34.54% (SD, 5.84%; range, 21.7%-44.4%), platelet counts from 31,000/mm(3) to 160,000/mm(3), and a mean INR of 1.50 (SD, 0.39; range, 0.98-2.59). Postoperative bleeding occurred during only 1 procedure (2.9%), and local pressure with gauze was effective for achieving hemostasis. No statistically significant difference in the time to hemostasis was found between the 2 groups. CONCLUSIONS: This study found a low risk of bleeding for tooth extractions in patients with liver cirrhosis, INRs of 2.50 or less, and platelet counts of 30,000/mm(3) or greater. Blood transfusions were not needed, and in the case of postoperative bleeding, the use of local hemostatic measures was satisfactory. CI - Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Perdigão, João Paulo Veloso AU - Perdigão JP AD - School of Dentistry, Federal University of Ceará, Fortaleza, Brazil. FAU - de Almeida, Paulo César AU - de Almeida PC FAU - Rocha, Tarciso Daniel Santos AU - Rocha TD FAU - Mota, Mário Rogério Lima AU - Mota MR FAU - Soares, Eduardo Costa Studart AU - Soares EC FAU - Alves, Ana Paula Negreiros Nunes AU - Alves AP FAU - Sousa, Fabrício Bitu AU - Sousa FB LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Antifibrinolytic Agents) RN - 6T84R30KC1 (Tranexamic Acid) SB - AIM SB - D SB - IM MH - Adult MH - Antifibrinolytic Agents/administration & dosage MH - Cross-Sectional Studies MH - *Dental Care for Chronically Ill MH - Female MH - Hemostatic Techniques MH - Humans MH - International Normalized Ratio MH - Liver Cirrhosis/*complications/surgery MH - Liver Transplantation MH - Male MH - Middle Aged MH - Oral Hemorrhage/etiology/*prevention & control MH - Platelet Count MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Preoperative Care MH - Pressure MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tranexamic Acid/administration & dosage MH - Treatment Outcome MH - Young Adult EDAT- 2012/03/01 06:00 MHDA- 2012/04/24 06:00 CRDT- 2012/03/01 06:00 PHST- 2011/07/17 00:00 [received] PHST- 2011/10/11 00:00 [revised] PHST- 2011/10/29 00:00 [accepted] PHST- 2012/03/01 06:00 [entrez] PHST- 2012/03/01 06:00 [pubmed] PHST- 2012/04/24 06:00 [medline] AID - S0278-2391(11)01725-3 [pii] AID - 10.1016/j.joms.2011.10.033 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2012 Mar;70(3):e177-84. doi: 10.1016/j.joms.2011.10.033. PMID- 26868520 OWN - NLM STAT- MEDLINE DCOM- 20180205 LR - 20180313 IS - 1096-9101 (Electronic) IS - 0196-8092 (Linking) VI - 48 IP - 5 DP - 2016 Jul TI - Choosing between intraoral or extraoral, red or infrared laser irradiation after impacted third molar extraction. PG - 511-8 LID - 10.1002/lsm.22488 [doi] AB - BACKGROUND AND OBJECTIVE: Swelling and trismus are complications experienced by nearly all subjects after undergoing oral surgery for the removal of impacted teeth. The main purpose of this paper was to compare the effects of photobiomodulation therapy (PBMT) at two different wavelengths applied intra-orally and extra-orally on facial swelling and trismus in the postoperative period following the extraction of impacted mandibular third molars. STUDY DESIGN/MATERIALS AND METHODS: Sixty subjects were randomly divided into five groups, taking into account the type of laser therapy applied after surgery (intraoral or extraoral irradiation with 660 nm laser; intraoral or extraoral irradiation with 808 nm; and sham irradiation). Two and seven days after the surgery, two blinded evaluators measured the subjects' faces (swelling), and mouth opening (trismus). RESULTS: There was a statistically significant interaction between the irradiation site and wavelength (swelling and trismus were smaller if the red laser was applied intra-orally or if infrared laser was applied extra-orally). The intra-group analyses showed that 808 nm laser applied extra-orally favored reductions in postoperative facial swelling and trismus, although the inter-group comparisons revealed no statistically significant differences. CONCLUSION: Besides energy parameters, the combination of irradiation site and wavelength drive the results of phototherapy after the removal of impacted teeth. Lasers Surg. Med. 48:511-518, 2016. © 2016 Wiley Periodicals, Inc. CI - © 2016 Wiley Periodicals, Inc. FAU - Sierra, Simone Oliveira AU - Sierra SO AD - Rehabilitation Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. FAU - Deana, Alessandro Melo AU - Deana AM AD - Biophotonics Applied to Health Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. FAU - Bussadori, Sandra Kalil AU - Bussadori SK AD - Rehabilitation Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. AD - Biophotonics Applied to Health Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. FAU - da Mota, Ana Carolina Costa AU - da Mota AC AD - Biophotonics Applied to Health Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. FAU - Ferrari, Raquel Agnelli Mesquita AU - Ferrari RA AD - Rehabilitation Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. AD - Biophotonics Applied to Health Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. FAU - do Vale, Katia Llanos AU - do Vale KL AD - Biophotonics Applied to Health Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. FAU - Fernandes, Kristianne Porta Santos AU - Fernandes KP AD - Biophotonics Applied to Health Sciences Post Graduation Program, Universidade Nove de Julho/UNINOVE, Rua Vergueiro, 249, São Paulo, São Paulo, 01504-001, Brazil. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20160211 PL - United States TA - Lasers Surg Med JT - Lasers in surgery and medicine JID - 8007168 SB - IM MH - Adult MH - Double-Blind Method MH - Edema/etiology/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Infrared Rays/*therapeutic use MH - Low-Level Light Therapy/*methods MH - Male MH - Molar, Third/*surgery MH - Mouth Diseases/etiology/prevention & control MH - Postoperative Care/*methods MH - Postoperative Complications/*prevention & control MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/etiology/prevention & control OTO - NOTNLM OT - *photobiomodulation therapy OT - *phototherapy OT - *randomized controlled trial OT - *tooth extraction EDAT- 2016/02/13 06:00 MHDA- 2018/02/06 06:00 CRDT- 2016/02/13 06:00 PHST- 2016/01/28 00:00 [accepted] PHST- 2016/02/13 06:00 [entrez] PHST- 2016/02/13 06:00 [pubmed] PHST- 2018/02/06 06:00 [medline] AID - 10.1002/lsm.22488 [doi] PST - ppublish SO - Lasers Surg Med. 2016 Jul;48(5):511-8. doi: 10.1002/lsm.22488. Epub 2016 Feb 11. PMID- 26578119 OWN - NLM STAT- MEDLINE DCOM- 20171030 LR - 20181113 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 20 IP - 7 DP - 2016 Sep TI - Oral pregabalin for postoperative pain relief after third molar extraction: a randomized controlled clinical trial. PG - 1819-26 LID - 10.1007/s00784-015-1657-3 [doi] AB - OBJECTIVES: The aim of this randomized controlled clinical trial was to evaluate the efficacy and safety of pregabalin administered pre- and postoperatively in patients with pain and swelling due to the surgical removal of impacted lower third molars. MATERIALS AND METHODS: The final study sample comprised 60 volunteers (23 males and 37 females). Group 1 (n = 30) received 75 mg oral pregabalin 1 h before surgery and 1 h after surgery. Group 2 (n = 30) served as a control group and received no pregabalin. Both groups were administered with 650 mg paracetamol every 8 h for 2 days. Postoperative pain intensity and swelling were measured using a visual analog scale (VAS); pain relief experienced was reported using a four-point verbal rating scale (VRS); the rescue medication requirement, adverse effects, and global impression of the medication were also recorded. RESULTS: No significant difference in pain intensity (VAS) was observed between the groups. However, fewer rescue medication tablets were needed by pregabalin-treated patients than by controls (p = 0.021). The frequency and intensity of adverse effects were significantly higher in pregabalin-treated patients (p < 0.001), although no serious adverse events occurred. No significant difference in the degree of swelling was observed in any measurement except that from mandibular angle to lip junction, which showed lesser inflammation in the pregabalin group at 24 h post-surgery (p = 0.011). The global opinion on the medication received was more positive in the pregabalin group (p = 0.042). CONCLUSIONS: The administration of pregabalin reduces the requirement for rescue medication after third molar surgery and results in a more constant pain level, with fewer peaks of pain intensity. CLINICAL RELEVANCE: These findings suggest that pregabalin may be useful to control acute postoperative pain. Adverse effects are known to be reduced at the low pregabalin dose used in our study. FAU - Olmedo-Gaya, Maria Victoria AU - Olmedo-Gaya MV AD - Department of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, Campus Universitario de Cartuja, 18071, Granada, Spain. FAU - Manzano-Moreno, Francisco J AU - Manzano-Moreno FJ AUID- ORCID: 0000-0002-3176-7613 AD - Department of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, Campus Universitario de Cartuja, 18071, Granada, Spain. fjmanza@ugr.es. AD - Biomedical Research Group (BIO277), Junta de Andalucía, Granada, Spain. fjmanza@ugr.es. FAU - Galvez-Mateos, Rafael AU - Galvez-Mateos R AD - Department of Anesthesia, Virgen de las Nieves University Hospital, Granada, Spain. FAU - González-Rodriguez, Maria Paloma AU - González-Rodriguez MP AD - Department of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, Campus Universitario de Cartuja, 18071, Granada, Spain. FAU - Talero-Sevilla, Cristina AU - Talero-Sevilla C AD - Department of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, Campus Universitario de Cartuja, 18071, Granada, Spain. FAU - Vallecillo-Capilla, Manuel AU - Vallecillo-Capilla M AD - Department of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, Campus Universitario de Cartuja, 18071, Granada, Spain. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20151118 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Analgesics) RN - 55JG375S6M (Pregabalin) SB - D MH - Administration, Oral MH - Adolescent MH - Adult MH - Analgesics/administration & dosage/*therapeutic use MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Pregabalin/administration & dosage/*therapeutic use MH - Tooth Extraction MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - Acute pain OT - Postoperative pain OT - Pregabalin OT - Surgery OT - Third molar EDAT- 2015/11/19 06:00 MHDA- 2017/10/31 06:00 CRDT- 2015/11/19 06:00 PHST- 2015/02/18 00:00 [received] PHST- 2015/11/10 00:00 [accepted] PHST- 2015/11/19 06:00 [entrez] PHST- 2015/11/19 06:00 [pubmed] PHST- 2017/10/31 06:00 [medline] AID - 10.1007/s00784-015-1657-3 [pii] AID - 10.1007/s00784-015-1657-3 [doi] PST - ppublish SO - Clin Oral Investig. 2016 Sep;20(7):1819-26. doi: 10.1007/s00784-015-1657-3. Epub 2015 Nov 18. PMID- 23969904 OWN - NLM STAT- MEDLINE DCOM- 20150909 LR - 20151119 IS - 1806-4760 (Electronic) IS - 0103-6440 (Linking) VI - 24 IP - 3 DP - 2013 TI - Tenascin and fibronectin expression after pulp capping with different hemostatic agents: a preliminary study. PG - 188-93 LID - S0103-64402013000300188 [pii] LID - 10.1590/0103-6440201302168 [doi] AB - This study investigated the expression of extracellular matrix glycoproteins tenascin (TN) and fibronectin (FN) in pulp repair after capping with calcium hydroxide (CH), following different hemostasis protocols. Class I cavities with a pulp exposure were prepared in 42 human third molars scheduled for extraction. Different hemostatic agents (0.9% saline solution, 5.25% sodium hypochlorite and 2% chlorhexidine digluconate) were used and pulps were capped with CH cement. After 7, 30 or 90 days, teeth were extracted, formalin-fixed, and prepared for immunohistochemical technique. Hemostatic agents did not influence the expression of TN and FN. Both glycoproteins were found in the entire the pulp tissue and around collagen fibers, but were absent in the mineralized tissues. In the predentin, TN showed positive immunostaining and FN had a variable expression. Within 7 days post-treatment, a slightly more pronounced immunostaining on the pulp exposure site was observed. Within 30 days, TN and FN demonstrated a positive expression around the dentin barrier and at 90 days, a thin and linear expression of TN and FN was delimitating the reparative dentin. In conclusion, hemostatic agents did not influence TN and FN expression. Immunostaining for TN and FN was seen in different regions and periods, demonstrating their role in pulp repair. FAU - Baldissera, Elaine Zanchin AU - Baldissera EZ AD - Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil. FAU - Silva, Adriana Fernandes da AU - Silva AF FAU - Gomes, Ana Paula Neutzling AU - Gomes AP FAU - Etges, Adriana AU - Etges A FAU - Botero, Tatiana AU - Botero T FAU - Demarco, Flávio Fernando AU - Demarco FF FAU - Tarquinio, Sandra Beatriz Chaves AU - Tarquinio SB LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Brazil TA - Braz Dent J JT - Brazilian dental journal JID - 9214652 RN - 0 (Composite Resins) RN - 0 (Fibronectins) RN - 0 (Filtek Z250) RN - 0 (Hemostatics) RN - 0 (Pulp Capping and Pulpectomy Agents) RN - 0 (Tenascin) RN - 0 (single bond) RN - 451W47IQ8X (Sodium Chloride) RN - 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate) RN - 9007-34-5 (Collagen) RN - DY38VHM5OD (Sodium Hypochlorite) RN - MOR84MUD8E (chlorhexidine gluconate) RN - PF5DZW74VN (Calcium Hydroxide) RN - R4KO0DY52L (Chlorhexidine) SB - D MH - Adult MH - Bisphenol A-Glycidyl Methacrylate/chemistry MH - Calcium Hydroxide/therapeutic use MH - Chlorhexidine/analogs & derivatives/therapeutic use MH - Collagen/analysis MH - Composite Resins/chemistry MH - Dental Pulp/chemistry MH - *Dental Pulp Capping MH - Dental Pulp Exposure/therapy MH - Dental Restoration, Permanent/methods MH - Dentin/chemistry MH - Dentin, Secondary/chemistry MH - Fibronectins/*analysis MH - Follow-Up Studies MH - Hemostatics/*therapeutic use MH - Humans MH - Pulp Capping and Pulpectomy Agents/*therapeutic use MH - Sodium Chloride/therapeutic use MH - Sodium Hypochlorite/therapeutic use MH - Tenascin/*analysis MH - Tooth Extraction MH - Young Adult EDAT- 2013/08/24 06:00 MHDA- 2015/09/10 06:00 CRDT- 2013/08/24 06:00 PHST- 2013/01/24 00:00 [received] PHST- 2013/04/17 00:00 [accepted] PHST- 2013/08/24 06:00 [entrez] PHST- 2013/08/24 06:00 [pubmed] PHST- 2015/09/10 06:00 [medline] AID - S0103-64402013000300188 [pii] AID - 10.1590/0103-6440201302168 [doi] PST - ppublish SO - Braz Dent J. 2013;24(3):188-93. doi: 10.1590/0103-6440201302168. PMID- 22398186 OWN - NLM STAT- MEDLINE DCOM- 20121024 LR - 20181201 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 70 IP - 8 DP - 2012 Aug TI - Is adjuvant laser therapy effective for preventing pain, swelling, and trismus after surgical removal of impacted mandibular third molars? A systematic review and meta-analysis. PG - 1789-801 LID - 10.1016/j.joms.2012.01.008 [doi] AB - PURPOSE: To assess the efficacy and safety of low-level laser energy irradiation (LLEI) for decreasing pain, swelling, and trismus after surgical removal of impacted mandibular third molars (IMTMs). MATERIALS AND METHODS: MEDLINE, EMBASE, and the Central Register of Controlled Trials of the Cochrane Library were searched from their inception, and conference proceedings, cross-references, and gray literature were searched for the last 5 years for randomized and quasi-randomized controlled trials that evaluated the effects of any type of LLEI, compared with active or inactive treatments, in patients undergoing surgical removal of IMTMs. Risk of bias in included studies was assessed by 2 independent evaluators using the Cochrane Risk of Bias tool. A random-effects model meta-analysis was used to estimate the mean difference of trismus between the groups. Heterogeneity was assessed using Cochran χ(2) and I(2). RESULTS: Ten eligible trials were included in this systematic review. The included studies overall had a moderate risk of bias. Because of heterogeneity in the intervention and outcomes assessments, pain and swelling outcomes were only qualitatively summarized and indicated no beneficial effects of LLEI over placebo. Patients receiving LLEI had an average of 4.2 mm (95% confidence interval, 1.2 to 7.2) and 5.2 mm (95% confidence interval, 1.8 to 8.2) less trismus than patients receiving no active treatment on the second and seventh day after the surgery, respectively. CONCLUSIONS: There was no benefit of LLEI on pain or swelling and a moderate benefit on trismus after removal of IMTMs. It is necessary to standardize the intervention and outcomes assessment and to conduct adequately powered, well-designed trials to evaluate the efficacy of LLEI. CI - Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Brignardello-Petersen, Romina AU - Brignardello-Petersen R AD - Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada. rominabp@gmail.com FAU - Carrasco-Labra, Alonso AU - Carrasco-Labra A FAU - Araya, Ignacio AU - Araya I FAU - Yanine, Nicolas AU - Yanine N FAU - Beyene, Joseph AU - Beyene J FAU - Shah, Prakesh S AU - Shah PS LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20120306 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Edema/*prevention & control MH - Humans MH - Low-Level Light Therapy/*methods MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications/*prevention & control MH - Radiotherapy, Adjuvant MH - Safety MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/*prevention & control EDAT- 2012/03/09 06:00 MHDA- 2012/10/25 06:00 CRDT- 2012/03/09 06:00 PHST- 2011/08/20 00:00 [received] PHST- 2012/01/04 00:00 [revised] PHST- 2012/01/05 00:00 [accepted] PHST- 2012/03/09 06:00 [entrez] PHST- 2012/03/09 06:00 [pubmed] PHST- 2012/10/25 06:00 [medline] AID - S0278-2391(12)00097-3 [pii] AID - 10.1016/j.joms.2012.01.008 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2012 Aug;70(8):1789-801. doi: 10.1016/j.joms.2012.01.008. Epub 2012 Mar 6. PMID- 25721919 OWN - NLM STAT- MEDLINE DCOM- 20160311 LR - 20161125 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 44 IP - 7 DP - 2015 Jul TI - Evaluation of fibrin sealant as a wound closure agent in mandibular third molar surgery--a prospective, randomized controlled clinical trial. PG - 871-5 LID - S0901-5027(15)00053-3 [pii] LID - 10.1016/j.ijom.2015.02.001 [doi] AB - The aim of this randomized controlled trial was to assess the effectiveness of fibrin sealants in achieving haemostasis and wound closure following mandibular third molar extraction, in comparison with conventional suturing. Thirty patients with bilateral mandibular third molar impactions were recruited for the study. Using a split-mouth study design, wound closure following extraction was done using fibrin sealant on the study side and suturing on the control side. Sample allocation was done by simple randomization. The primary outcome measures were (1) the time taken to achieve wound closure and haemostasis and (2) postoperative mouth opening, pain, and swelling. Data analysis involved descriptive statistics and paired t-tests (P<0.05). IBM SPSS software (v.20.0) was used for the data analysis. The study group demonstrated a statistically significant reduction in duration to achieve haemostasis (1.2 vs. 251.9s; P<0.001) and wound closure (152.8 vs. 328.8s; P<0.001) in comparison with the control group. The study group also exhibited significantly reduced pain scores (2.0 vs. 3.5; P<0.001) and increased post-surgical mouth opening (P<0.001). No adverse effects of fibrin sealant were observed. In conclusion, fibrin sealant is a superior intraoral wound closure and haemostatic agent and a worthy alternative to suturing. CI - Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Gogulanathan, M AU - Gogulanathan M AD - Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. FAU - Elavenil, P AU - Elavenil P AD - Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. Electronic address: elavenilomfs@gmail.com. FAU - Gnanam, A AU - Gnanam A AD - Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. FAU - Raja, V B Krishnakumar AU - Raja VB AD - Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150223 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Fibrin Tissue Adhesive) SB - D SB - IM MH - Female MH - Fibrin Tissue Adhesive/*therapeutic use MH - Hemostasis, Surgical MH - Humans MH - Male MH - Molar, Third/diagnostic imaging/*surgery MH - Pain Measurement MH - Prospective Studies MH - Radiography, Panoramic MH - Suture Techniques MH - Tooth Extraction MH - Tooth, Impacted/diagnostic imaging/*surgery OTO - NOTNLM OT - fibrin sealant OT - haemostasis OT - third molar impaction OT - wound closure EDAT- 2015/02/28 06:00 MHDA- 2016/03/12 06:00 CRDT- 2015/02/28 06:00 PHST- 2014/04/04 00:00 [received] PHST- 2014/12/19 00:00 [revised] PHST- 2015/02/02 00:00 [accepted] PHST- 2015/02/28 06:00 [entrez] PHST- 2015/02/28 06:00 [pubmed] PHST- 2016/03/12 06:00 [medline] AID - S0901-5027(15)00053-3 [pii] AID - 10.1016/j.ijom.2015.02.001 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2015 Jul;44(7):871-5. doi: 10.1016/j.ijom.2015.02.001. Epub 2015 Feb 23. PMID- 29602626 OWN - NLM STAT- MEDLINE DCOM- 20190121 LR - 20190121 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 47 IP - 9 DP - 2018 Sep TI - Intra-alveolar epsilon-aminocaproic acid for the control of post-extraction bleeding in anticoagulated patients: randomized clinical trial. PG - 1138-1144 LID - S0901-5027(18)30069-9 [pii] LID - 10.1016/j.ijom.2018.02.013 [doi] AB - The aim of this study was to compare the effectiveness of the intra-alveolar administration of epsilon-aminocaproic acid (EACA) and daily gentle rinsing with EACA mouthwash with that of routine postoperative procedures for the control of bleeding after tooth extraction in anticoagulated patients. A randomized clinical trial was conducted involving 52 patients submitted to 140 tooth extractions, assigned randomly to two groups. The intervention group was treated with intra-alveolar administration of EACA immediately after surgery and gentle rinsing with EACA mouthwash during the postoperative period. The control group received routine postoperative recommendations. A single episode of immediate bleeding occurred in the intervention group. Late bleeding episodes occurred in 23 procedures (16.4%): 11 (15.7%) in the intervention group and 12 (17.1%) in the control group. Among the patients with late bleeding, 18 (78.3%) events were classified as moderate and were controlled by the patient applying pressure to a gauze pack placed over the extraction socket. The remaining five cases (21.7%) required re-intervention. No statistically significant difference in the frequency of postoperative bleeding was observed between the groups. Thus, routine measures were as effective for the control of bleeding after simple tooth extractions in anticoagulated patients as the topical administration of EACA. CI - Copyright © 2018 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - da Silva, R V AU - da Silva RV AD - Medical Clinic Programme of the Faculty of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: rosangela.varella@saojose.br. FAU - Gadelha, T B AU - Gadelha TB AD - Haematology Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Luiz, R R AU - Luiz RR AD - Institute for Studies in Public Health (IESC), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Torres, S R AU - Torres SR AD - Department of Oral Pathology and Diagnostics, Faculty of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20180327 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anticoagulants) RN - 0 (Antifibrinolytic Agents) RN - 0 (Mouthwashes) RN - U6F3787206 (Aminocaproic Acid) SB - D SB - IM CIN - J Am Dent Assoc. 2018 Nov;149(11):e153. PMID: 30005913 MH - Administration, Topical MH - Adult MH - Aged MH - Aged, 80 and over MH - Aminocaproic Acid/administration & dosage/*therapeutic use MH - Anticoagulants/administration & dosage MH - Antifibrinolytic Agents/administration & dosage/*therapeutic use MH - Female MH - Humans MH - Male MH - Middle Aged MH - Mouthwashes MH - Postoperative Hemorrhage/*prevention & control MH - Risk Factors MH - *Tooth Extraction MH - Treatment Outcome OTO - NOTNLM OT - anticoagulated patients OT - epsilon-aminocaproic acid OT - tooth extractions EDAT- 2018/04/01 06:00 MHDA- 2019/01/22 06:00 CRDT- 2018/04/01 06:00 PHST- 2017/05/08 00:00 [received] PHST- 2018/02/14 00:00 [revised] PHST- 2018/02/23 00:00 [accepted] PHST- 2018/04/01 06:00 [pubmed] PHST- 2019/01/22 06:00 [medline] PHST- 2018/04/01 06:00 [entrez] AID - S0901-5027(18)30069-9 [pii] AID - 10.1016/j.ijom.2018.02.013 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2018 Sep;47(9):1138-1144. doi: 10.1016/j.ijom.2018.02.013. Epub 2018 Mar 27. PMID- 27933720 OWN - NLM STAT- MEDLINE DCOM- 20181010 LR - 20181010 IS - 1708-8208 (Electronic) IS - 1523-0899 (Linking) VI - 19 IP - 3 DP - 2017 Jun TI - Autogenous bone grafting for treatment of osseous defect after impacted mandibular third molar extraction: A randomized controlled trial. PG - 572-580 LID - 10.1111/cid.12466 [doi] AB - BACKGROUND: Extraction of impacted mandibular third molar (M3) has been cited as causing osseous defect at the distal aspect of the adjacent second molar (M2). PURPOSE: This randomized controlled trial was aimed to evaluate the effect of autogenous bone grafting in situ for regeneration of periodontal osseous defect distal to the M2 compared with non-grafting after impacted M3 removal. MATERIALS AND METHODS: A total of 60 sites in 51 adult patients were enrolled and randomly assigned to the control group or the test group. In both groups, the M3 was extracted using a piezosurgical device, and the distal root surface of M2 was scaled and root planned. In addition, the removed alveolar bone was grinded to particles and grafted to the distal osseous defect of M2 in the test group. The primary outcome variable was the osseous defect depth (ODD), the secondary outcome variables were probing pocket depth (PD) and clinical attachment level (CAL) on the disto-buccal aspect of the M2 during a 12-month follow-up period. Postoperative symptom at 7-day postoperatively and adverse events were also recorded and analyzed. RESULTS: The patient characteristics were homogeneous between the 2 groups. Six and 12 months after surgery, there were statistically significant bone fill in both groups (P < .01). Moreover, the ODD and CAL in the test group were significantly lower than the control group at every postoperative re-entry (P < .01). The postoperative symptom was more severe in the test group than the control group, but the difference was not significant (P > .05). CONCLUSIONS: The result of this study demonstrated that scaling and root planning was beneficial to periodontal healing of M2 after impacted M3 extraction. Addition of autogenous bone grafting for the treatment of osseous defects distal to M2 was safe and more effective than periodontal treatment alone. (Registry Number: ChiCTR-IOC-15006561). CI - © 2016 Wiley Periodicals, Inc. FAU - Ge, Jing AU - Ge J AD - Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medical; Shanghai Key Laboratory of Stomatology, Shanghai, PRC. FAU - Yang, Chi AU - Yang C AD - Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medical; Shanghai Key Laboratory of Stomatology, Shanghai, PRC. FAU - Zheng, Jiawei AU - Zheng J AD - Department of Oral-maxillofacial Head and Neck Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medical; Shanghai Key Laboratory of Stomatology, Shanghai, PRC. FAU - Hu, Yingkai AU - Hu Y AD - Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medical; Shanghai Key Laboratory of Stomatology, Shanghai, PRC. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20161208 PL - United States TA - Clin Implant Dent Relat Res JT - Clinical implant dentistry and related research JID - 100888977 SB - D SB - IM MH - Adult MH - Bone Regeneration/physiology MH - *Bone Transplantation MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Transplantation, Autologous OTO - NOTNLM OT - bone regeneration OT - periodontal bone loss OT - periodontal disease OT - randomized controlled trial OT - third molar OT - tooth extraction EDAT- 2016/12/10 06:00 MHDA- 2018/10/12 06:00 CRDT- 2016/12/10 06:00 PHST- 2016/09/04 00:00 [received] PHST- 2016/09/17 00:00 [revised] PHST- 2016/10/06 00:00 [accepted] PHST- 2016/12/10 06:00 [pubmed] PHST- 2018/10/12 06:00 [medline] PHST- 2016/12/10 06:00 [entrez] AID - 10.1111/cid.12466 [doi] PST - ppublish SO - Clin Implant Dent Relat Res. 2017 Jun;19(3):572-580. doi: 10.1111/cid.12466. Epub 2016 Dec 8. PMID- 28811076 OWN - NLM STAT- MEDLINE DCOM- 20180904 LR - 20180904 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 47 IP - 2 DP - 2018 Feb TI - Submucosal injection of dexamethasone and methylprednisolone for the control of postoperative sequelae after third molar surgery: randomized controlled trial. PG - 228-233 LID - S0901-5027(17)31548-5 [pii] LID - 10.1016/j.ijom.2017.07.009 [doi] AB - Pain, swelling, and trismus are known sequelae of third molar surgery that can significantly affect the individual's quality of life (QOL). These should be minimized to improve QOL. The purpose of this study was to compare the effects of the preoperative submucosal administration of equivalent doses of two commonly used steroids on these postoperative sequelae. A randomized controlled clinical trial was conducted involving 60 subjects requiring the removal of impacted mandibular third molars. Extraction cases with a similar difficulty index were included. The participants were allocated randomly to three groups: the placebo group received normal saline injection (control), while the 8mg dexamethasone group and 40mg methylprednisolone group received submucosal injections of these steroids preoperatively. Each participant was assessed for postoperative pain, swelling, and trismus, along with a subjective assessment of QOL through a structured questionnaire. The participants administered dexamethasone showed significant reductions in pain and trismus compared to the control group (P<0.05). Submucosal injection of dexamethasone was found to be superior to methylprednisolone only in terms of the reduction in swelling. QOL was minimally affected in patients administered dexamethasone as compared to methylprednisolone and control subjects. The preoperative submucosal use of steroids can be considered an effective, safe, and simple therapeutic strategy to reduce swelling, pain, and trismus after the surgical removal of impacted mandibular third molars. CI - Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Chugh, A AU - Chugh A AD - Department of Dentistry, All India Institute of Medical Science (AIIMS), Jodhpur, India. Electronic address: ankitamody@gmail.com. FAU - Singh, S AU - Singh S AD - Department of Pharmacology, All India Institute of Medical Science (AIIMS), Jodhpur, India. FAU - Mittal, Y AU - Mittal Y AD - Department of Dentistry, All India Institute of Medical Science (AIIMS), Jodhpur, India. FAU - Chugh, V AU - Chugh V AD - Department of Dentistry, All India Institute of Medical Science (AIIMS), Jodhpur, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170812 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adult MH - Dexamethasone/*administration & dosage MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections MH - Male MH - Methylprednisolone/*administration & dosage MH - Molar, Third/*surgery MH - Pain Measurement MH - Postoperative Complications/*drug therapy MH - Prospective Studies MH - Quality of Life MH - Single-Blind Method MH - Surveys and Questionnaires MH - Tooth, Impacted/*surgery MH - Treatment Outcome OTO - NOTNLM OT - corticosteroids OT - dexamethasone OT - impacted third molar OT - methylprednisolone EDAT- 2017/08/16 06:00 MHDA- 2018/09/05 06:00 CRDT- 2017/08/17 06:00 PHST- 2016/09/09 00:00 [received] PHST- 2017/06/30 00:00 [revised] PHST- 2017/07/12 00:00 [accepted] PHST- 2017/08/16 06:00 [pubmed] PHST- 2018/09/05 06:00 [medline] PHST- 2017/08/17 06:00 [entrez] AID - S0901-5027(17)31548-5 [pii] AID - 10.1016/j.ijom.2017.07.009 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2018 Feb;47(2):228-233. doi: 10.1016/j.ijom.2017.07.009. Epub 2017 Aug 12. PMID- 23159124 OWN - NLM STAT- MEDLINE DCOM- 20130605 LR - 20121119 IS - 2212-4411 (Electronic) VI - 114 IP - 6 DP - 2012 Dec TI - Antibiotic prophylaxis in third molar surgery: a review. PG - e5-12 LID - S2212-4403(12)00129-0 [pii] LID - 10.1016/j.oooo.2011.10.023 [doi] AB - OBJECTIVE: Controversy exists about the efficacy of antibiotic prophylaxis in preventing complications after lower third molar surgery. For evidence-based recommendation, a review was performed on clinical trials reporting the use of antibiotic prophylaxis compared with no treatment or placebo with "infection" as outcome. STUDY DESIGN: Useful studies were identified using Embase, Cochrane, and Ovid Medline (1966-January 2011) and references in retrieved reports and review articles. Twenty-three eligible studies were identified and reviewed by independent investigators using 2 quality assessment scales. RESULTS: The review procedure revealed 15 "low-quality" and 8 "high-quality" articles, with major differences in treatment modalities and heterogeneity of design. CONCLUSIONS: There is limited evidence supporting the efficacy of commonly used antibiotics in preventing complications after lower third molar removal. Well designed and well reported high-quality randomized trials considering known risk factors and taking clinical outcomes into account are needed to reach final consensus on the efficacy of antibiotic prophylaxis to allow evidence-based recommendations. CI - Copyright © 2012 Elsevier Inc. All rights reserved. FAU - Oomens, Marjolijn A E AU - Oomens MA AD - Department of Oral and Maxillofacial Surgery/Oral Pathology, Vrije Universiteit Medical Center/Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands. FAU - Forouzanfar, Tymour AU - Forouzanfar T LA - eng PT - Journal Article PT - Review DEP - 20120530 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 SB - D SB - IM MH - *Antibiotic Prophylaxis MH - Humans MH - Molar, Third/*surgery MH - Randomized Controlled Trials as Topic EDAT- 2012/11/20 06:00 MHDA- 2013/06/06 06:00 CRDT- 2012/11/20 06:00 PHST- 2011/06/10 00:00 [received] PHST- 2011/10/04 00:00 [revised] PHST- 2011/10/13 00:00 [accepted] PHST- 2012/11/20 06:00 [entrez] PHST- 2012/11/20 06:00 [pubmed] PHST- 2013/06/06 06:00 [medline] AID - S2212-4403(12)00129-0 [pii] AID - 10.1016/j.oooo.2011.10.023 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Dec;114(6):e5-12. doi: 10.1016/j.oooo.2011.10.023. Epub 2012 May 30. PMID- 33161499 OWN - NLM STAT- MEDLINE DCOM- 20210107 LR - 20210111 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 25 IP - 1 DP - 2021 Jan TI - Effectiveness of anesthetic solutions for pain control in lower third molar extraction surgeries: a systematic review of randomized clinical trials with network meta-analysis. PG - 1-22 LID - 10.1007/s00784-020-03675-w [doi] AB - OBJECTIVE: To assess the effectiveness of different anesthetic solutions for pain control immediately after the extraction of lower third molars. METHODS: Nine databases were used to identify randomized clinical trials, without restriction of language or year of publication. The "JBI Critical Appraisal Tools for Systematic Reviews" was used to assess the risk of bias in the studies. The network meta-analysis was performed to compare the effectiveness of different anesthetics to control the pain immediately after the surgery of lower third molars, using the standardized mean difference (SMD) as the effect estimate. The GRADE approach was used to assess the certainty of evidence. RESULTS: The search presented 13,739 initial results, from which 45 met the eligibility criteria and presented low to moderate risk of bias. Thirteen studies were included in the meta-analysis. The 2% lidocaine + clonidine presented the lowest pain scores (SMD = - 1.44; - 2.72 to - 0.16) compared to 4% articaine + adrenaline, followed by 0.5% bupivacaine + adrenaline (SMD = - 1.36; - 2.13 to - 0.59). The certainty of evidence varied between very low to moderate. CONCLUSION: 2% lidocaine + clonidine and 0.5% bupivacaine + adrenaline were the anesthetics with the highest probability for pain control immediately after the surgical procedure of removing impacted lower third molars. CLINICAL SIGNIFICANCE: The use of an adequate anesthetic with effective pain control can contribute to a more comfortable postoperative period. FAU - Rossi, Marco Tulio AU - Rossi MT AD - Postgraduate Program in Dentistry, Faculdade São Leopoldo Mandic, Campinas, Brazil. FAU - de Oliveira, Murilo Navarro AU - de Oliveira MN AD - Postgraduate Program in Dentistry, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil. FAU - Vidigal, Maria Tereza Campos AU - Vidigal MTC AD - School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil. FAU - de Andrade Vieira, Walbert AU - de Andrade Vieira W AD - Department of Restorative Dentistry, Endodontics Division, School of Dentistry of Piracicaba, State University of Campinas, UNICAMP, Piracicaba, Brazil. FAU - Figueiredo, Cristiano Elias AU - Figueiredo CE AD - Postgraduate Program in Dentistry, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil. FAU - Blumenberg, Cauane AU - Blumenberg C AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil. FAU - de Almeida, Vinicius Lima AU - de Almeida VL AD - Residency Training in Oral and Maxillofacial Surgery, School of Medicine, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil. FAU - Paranhos, Luiz Renato AU - Paranhos LR AUID- ORCID: 0000-0002-7599-0120 AD - Department of Preventive and Community Dentistry, School of Dentistry, Federal University of Uberlândia, Campus Umuarama, Av. Pará, 1720, Bloco 2G, sala 1, Uberlândia, Minas Gerais, 38405-320, Brazil. paranhos.lrp@gmail.com. FAU - Oliveira, Luciana Butini AU - Oliveira LB AD - Postgraduate Program in Dentistry, Faculdade São Leopoldo Mandic, Campinas, Brazil. FAU - Siqueira, Walter Luiz AU - Siqueira WL AD - College of Dentistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. FAU - de Brito Júnior, Rui Barbosa AU - de Brito Júnior RB AD - Postgraduate Program in Dentistry, Faculdade São Leopoldo Mandic, Campinas, Brazil. LA - eng GR - 001/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior/ GR - 307808/2018-1/Conselho Nacional de Desenvolvimento Científico e Tecnológico/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20201108 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Anesthetics, Local) SB - D MH - *Anesthetics, Local MH - Humans MH - *Molar, Third/surgery MH - Network Meta-Analysis MH - Pain MH - Pain, Postoperative/prevention & control MH - Randomized Controlled Trials as Topic OTO - NOTNLM OT - Anesthetics OT - Oral surgery OT - Systematic review OT - Third molar EDAT- 2020/11/09 06:00 MHDA- 2021/01/08 06:00 CRDT- 2020/11/08 20:37 PHST- 2020/09/22 00:00 [received] PHST- 2020/10/29 00:00 [accepted] PHST- 2020/11/09 06:00 [pubmed] PHST- 2021/01/08 06:00 [medline] PHST- 2020/11/08 20:37 [entrez] AID - 10.1007/s00784-020-03675-w [pii] AID - 10.1007/s00784-020-03675-w [doi] PST - ppublish SO - Clin Oral Investig. 2021 Jan;25(1):1-22. doi: 10.1007/s00784-020-03675-w. Epub 2020 Nov 8. PMID- 28249808 OWN - NLM STAT- MEDLINE DCOM- 20170831 LR - 20170831 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 75 IP - 7 DP - 2017 Jul TI - Potential for Osseous Regeneration of Platelet-Rich Fibrin-A Comparative Study in Mandibular Third Molar Impaction Sockets. PG - 1322-1329 LID - S0278-2391(17)30120-9 [pii] LID - 10.1016/j.joms.2017.01.035 [doi] AB - PURPOSE: This study investigated the potential of platelet-rich fibrin (PRF) for osseous regeneration and soft tissue healing in mandibular third molar impaction sockets. MATERIALS AND METHODS: A prospective in vivo study was performed. Randomization was performed after extraction. On one side, the socket was sutured primarily (control site); on the other side, autologous PRF gel was placed and then the socket was sutured (test site). Postoperatively, grid periapical radiographs were obtained at periodic intervals (weeks 1, 4, and 16) and digitalized. Gray-level values were measured at 3 different regions of the socket (for regions of newly formed bone) compared with the natural bone area using HL Image++ software, and the percentage bone fill was measured. Clinical evaluation of soft tissue healing was performed using the healing index of Landry et al (J Periodontol 60:212, 1994) at the specific intervals. RESULTS: Thirty healthy men and women (age range, 18 to 35 yr) with bilaterally impacted mandibular third molars were enrolled in this study. In general, there was markedly greater bone formation in sockets treated with PRF (P < .05). In the PRF group, the average gray-level values at the cervical, middle, and apical regions were 61.85 (standard deviation [SD], ±25.186), 64.54 (SD, ±24.831), and 67.80 (SD, ±23.946), respectively, with a mean value of 64.73 (SD, ±24.411). In the control group, these values were 51.58 (SD, ±15.286), 54.30 (SD, ±16.274), and 57.53 (SD, ±16.187), respectively, with a mean of 53.67 (SD, ±16.528). The average percentage of bone fill in the PRF group was 57.90 (SD, ±26.789) and that of the non-PRF group was 46.74 (SD, ±17.713; P < .05). Soft tissue healing as evaluated by the healing index of Landry et al also was found to be better at the PRF test site and it was statistically significant (P < .05). CONCLUSIONS: There was evidence for better osseous regeneration and soft tissue healing in response to PRF. Further investigations to evaluate the application of PRF in other areas of oral and maxillofacial surgery are imperative. CI - Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Varghese, Mathew P AU - Varghese MP AD - Senior Lecturer, Department of Oral and Maxillofacial Surgery, PMS College of Dental Sciences and Research, Trivandrum, Kerala, India. Electronic address: mathewstar@gmail.com. FAU - Manuel, Suvy AU - Manuel S AD - Former Professor, Department of Oral and Maxillofacial Surgery, PMS College of Dental Sciences and Research, Trivandrum, Kerala, India. FAU - Kumar L K, Surej AU - Kumar L K S AD - Professor and Head of Department, Department of Oral and Maxillofacial Surgery, PMS College of Dental Sciences and Research, Trivandrum, Kerala, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20170204 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Fibrin Tissue Adhesive) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - *Bone Regeneration MH - Female MH - *Fibrin Tissue Adhesive/administration & dosage MH - Humans MH - Male MH - Molar, Third/*surgery MH - *Platelet-Rich Plasma MH - Prospective Studies MH - Tooth Socket/*surgery MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2017/03/03 06:00 MHDA- 2017/09/01 06:00 CRDT- 2017/03/03 06:00 PHST- 2016/06/01 00:00 [received] PHST- 2017/01/25 00:00 [revised] PHST- 2017/01/25 00:00 [accepted] PHST- 2017/03/03 06:00 [pubmed] PHST- 2017/09/01 06:00 [medline] PHST- 2017/03/03 06:00 [entrez] AID - S0278-2391(17)30120-9 [pii] AID - 10.1016/j.joms.2017.01.035 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2017 Jul;75(7):1322-1329. doi: 10.1016/j.joms.2017.01.035. Epub 2017 Feb 4. PMID- 26704192 OWN - NLM STAT- MEDLINE DCOM- 20160428 LR - 20181202 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 12 DP - 2015 Dec 24 TI - Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. PG - CD011385 LID - 10.1002/14651858.CD011385.pub2 [doi] AB - BACKGROUND: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease. The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. However, a systematic review of trials reporting outcomes after oral surgery or a dental procedure in people with an inherited bleeding disorder, with or without, the use of antifibrinolytic agents has not been performed to date. OBJECTIVES: The primary objective was to assess the efficacy of local or systemic use of antifibrinolytic agents to prevent bleeding complications in people with haemophilia or Von Willebrand disease undergoing oral or dental procedures. Secondary objectives were to assess if antifibrinolytic agents can replace or reduce the need for clotting factor concentrate therapy in people with haemophilia or Von Willebrand disease and to further establish the effects of these agents on bleeding in oral or dental procedures for each of these populations. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, compiled from electronic database searches of the Cochrane Central Register of Controlled Trials (CENTRAL), of MEDLINE and from handsearching of journals and conference abstract books. We additionally searched the reference lists of relevant articles and reviews. We searched PubMed, Embase and The Cochrane Library. Additional searches were performed in ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP).Date of last search of the Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register: 14 December 2015. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials in people with haemophilia or Von Willebrand disease undergoing oral or dental procedures using antifibrinolytic agents (tranexamic acid or epsilon aminocaproic acid) to prevent perioperative bleeding compared to no intervention or usual care with or without placebo. DATA COLLECTION AND ANALYSIS: Two authors independently screened the titles and abstracts of all identified articles. Full texts were obtained for potentially relevant abstracts and two authors independently assessed these for inclusion based on the selection criteria. A third author verified trial eligibility. Two authors independently performed data extraction and risk of bias assessments using standardized forms. MAIN RESULTS: While there were no eligible trials in people with Von Willebrand disease identified, two randomised, double-blind, placebo-controlled trials (total of 59 participants) in people with haemophilia undergoing dental extraction were included. One trial of tranexamic acid published in 1972 included 28 participants with mild, moderate or severe haemophilia A and B and one of epsilon aminocaproic acid published in 1971 included 31 people with haemophilia with factor VIII or factor IX levels less than 15%. Overall, the two included trials showed a beneficial effect of tranexamic acid and EACA, administered systemically, in reducing the number of bleedings, the amount of blood loss and the need for therapeutic clotting factor concentrates. Regarding postoperative bleeding, the tranexamic acid trial showed a risk difference of -0.64 (95% confidence interval -0.93 to - 0.36) and the EACA trial a risk difference of -0.50 (95% confidence interval 0.77 to -0.22). The combined risk difference of both trials was -0.57 (95% confidence interval -0.76 to -0.37), with the quality of the evidence (GRADE) for this outcome is rated as moderate. Side effects occurred once and required stopping epsilon aminocaproic acid (combined risk difference of -0.03 (95% CI -0.08 to 0.13). There was heterogeneity between the two trials regarding the proportion of people with severe haemophilia included, the concomitant standard therapy and fibrinolytic agent treatment regimens used. We cannot exclude that a selection bias has occurred in the epsilon aminocaproic acid trial, but overall the risk of bias appeared to be low for both trials. AUTHORS' CONCLUSIONS: Despite the discovery of a beneficial effect of systemically administered tranexamic acid and epsilon aminocaproic acid in preventing postoperative bleeding in people with haemophilia undergoing dental extraction, the limited number of randomised controlled trials identified, in combination with the small sample sizes and heterogeneity regarding standard therapy and treatment regimens between the two trials, do not allow us to conclude definite efficacy of antifibrinolytic therapy in oral or dental procedures in people with haemophilia. No trials were identified in people with Von Willebrand disease. FAU - van Galen, Karin P M AU - van Galen KP AD - Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT. FAU - Engelen, Eveline T AU - Engelen ET FAU - Mauser-Bunschoten, Evelien P AU - Mauser-Bunschoten EP FAU - van Es, Robert J J AU - van Es RJ FAU - Schutgens, Roger E G AU - Schutgens RE LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20151224 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Antifibrinolytic Agents) RN - 6T84R30KC1 (Tranexamic Acid) RN - 9001-27-8 (Factor VIII) RN - 9001-28-9 (Factor IX) RN - U6F3787206 (Aminocaproic Acid) SB - IM UIN - Cochrane Database Syst Rev. 2019 Apr 19;4:CD011385. PMID: 31002742 MH - Aminocaproic Acid/therapeutic use MH - Antifibrinolytic Agents/*therapeutic use MH - Blood Loss, Surgical/prevention & control MH - Factor IX/administration & dosage MH - Factor VIII/administration & dosage MH - Hemophilia A/complications/*drug therapy MH - Hemophilia B/complications/*drug therapy MH - Humans MH - Minor Surgical Procedures/adverse effects MH - Oral Hemorrhage/etiology/*prevention & control MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Randomized Controlled Trials as Topic MH - Surgery, Oral MH - Tooth Extraction/*adverse effects MH - Tranexamic Acid/therapeutic use MH - von Willebrand Diseases/complications/*drug therapy EDAT- 2015/12/26 06:00 MHDA- 2016/04/29 06:00 CRDT- 2015/12/26 06:00 PHST- 2015/12/26 06:00 [entrez] PHST- 2015/12/26 06:00 [pubmed] PHST- 2016/04/29 06:00 [medline] AID - 10.1002/14651858.CD011385.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2015 Dec 24;(12):CD011385. doi: 10.1002/14651858.CD011385.pub2. PMID- 28690083 OWN - NLM STAT- MEDLINE DCOM- 20171218 LR - 20171218 IS - 2212-4411 (Electronic) VI - 124 IP - 3 DP - 2017 Sep TI - Analgesic effects of preinjection low-level laser/light therapy (LLLT) before third molar surgery: a double-blind randomized controlled trial. PG - 240-247 LID - S2212-4403(17)30212-2 [pii] LID - 10.1016/j.oooo.2017.04.017 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the analgesic effects of low-level laser therapy (LLLT) on preinjection sites in patients scheduled for third molar removal. STUDY DESIGN: This double-blind randomized controlled trial included 163 healthy patients undergoing third molar extractions. The study participants were randomly divided into an LLLT and a placebo group. Objective and subjective data sets were obtained from physiologic feedback (heart rate and sweat response) and a questionnaire, respectively. In the LLLT group, each targeted injection site was irradiated twice with 198 mW continuous wave for 30 seconds with a 0.088 cm(2) focal spot at an applied energy of 5.94 J and fluence of 67.50 J/cm(2). Measurements were recorded from 4 time-points during data acquisition. RESULTS: There was no significant difference between the LLLT and placebo groups in pain experience scores associated with the injected sites for maxillary or mandibular third molar extractions. Mean heart rates before and during injection were lower in the LLLT group than in the placebo group for both maxillary and mandibular regions. No statistically significant differences were observed for any remaining parameters. CONCLUSIONS: The present data indicated that preinjection LLLT did not effectively decrease the pain felt during local anesthetic injections before third molar surgery. CI - Copyright © 2017 Elsevier Inc. All rights reserved. FAU - Tuk, Jacco G C AU - Tuk JGC AD - Department of Oral & Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Oral & Maxillofacial Surgery, Amstelland Hospital, Amstelveen, The Netherlands. Electronic address: J.G.Tuk@amc.uva.nl. FAU - van Wijk, Arjen J AU - van Wijk AJ AD - Department of Oral Health Sciences, Social Dentistry Division, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands. FAU - Mertens, Ine C AU - Mertens IC AD - Department of Oral & Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. FAU - Keleş, Zühal AU - Keleş Z AD - Department of Oral & Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. FAU - Lindeboom, Jérôme A H AU - Lindeboom JAH AD - Department of Oral & Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Oral & Maxillofacial Surgery, Amstelland Hospital, Amstelveen, The Netherlands. FAU - Milstein, Dan M J AU - Milstein DMJ AD - Department of Oral & Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170504 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Anesthesia, Dental/*methods MH - Dental Anxiety/diagnosis MH - Double-Blind Method MH - Feedback, Physiological MH - Female MH - Humans MH - Low-Level Light Therapy/*methods MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Management/*methods MH - Pain Measurement MH - Tooth Extraction MH - Treatment Outcome EDAT- 2017/07/12 06:00 MHDA- 2017/12/19 06:00 CRDT- 2017/07/11 06:00 PHST- 2016/12/22 00:00 [received] PHST- 2017/03/28 00:00 [revised] PHST- 2017/04/19 00:00 [accepted] PHST- 2017/07/12 06:00 [pubmed] PHST- 2017/12/19 06:00 [medline] PHST- 2017/07/11 06:00 [entrez] AID - S2212-4403(17)30212-2 [pii] AID - 10.1016/j.oooo.2017.04.017 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Sep;124(3):240-247. doi: 10.1016/j.oooo.2017.04.017. Epub 2017 May 4. PMID- 29504342 OWN - NLM STAT- MEDLINE DCOM- 20180807 LR - 20181202 IS - 1819-2718 (Electronic) IS - 1025-9589 (Linking) VI - 30 IP - 1 DP - 2018 Jan-Mar TI - Measure Of Frequency Of Alveolar Osteitis Using Two Different Methods Of Osteotomy In Mandibular Third Molar Impactions: A Double-Blind Randomized Clinical Trial. PG - 103-106 AB - BACKGROUND: Dento-alveolar surgical procedures involving third molar teeth are the most common surgical procedure in the field of surgery. The objective of this research was to analyse the impact of surgery on the incidence of alveolar osteitis after surgical removal of mandibular third molar and to compare two different bone cutting methods following impacted mandibular third molar surgery.. METHODS: This double blinded randomized clinical trial was executed at the OPD of Department of Oral and Maxillofacial Surgery, Dow University of Health Sciences, Karachi. The study duration was four months. It was conducted on 60 patients needing unilateral mandibular third molar impaction removal. Patients were randomized to two groups (i.e., physio dispenser group and slow speed handpiece group) before surgery. The surgical procedure was performed under local anaesthesia by using standardized cross infection protocol. The frequency of alveolar osteitis was evaluated on thirdday postoperatively. Alveolar osteitis was diagnosed and confirmed by patient's history and clinical evaluation. Post-operative sequelae were observed and recorded objectively. RESULTS: Out of 60 patients', five patients experienced alveolar osteitis, and the incidence rate was 8.3%. A significant pvalue of 0.000 was calculated using binomial test for comparison of alveolar osteitis among both groups. Inter-examiner reliability was assessed by kappa and good (62%) agreement, which was found among the examiners, who diagnosed alveolar osteitis clinically. Post-operative sequelae were insignificant in slow speed hand piece group. CONCLUSIONS: It was observed that alveolar osteitis was reported in physio-dispenser group; similarly, post-operative complications were also more in this group as compared with slow speed-hand piece group. No surgical complications were observed in slow speed-hand piece group suggesting slow speed hand piece mode of osteotomy to be safer for third molar extraction as compared with physio-dispenser. FAU - Rashid, Hina AU - Rashid H AD - Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan. FAU - Hussain, Azmina AU - Hussain A AD - Dr. Ishrat-ul-Ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi-Pakistan. FAU - Sheikh, Abdul Hafeez AU - Sheikh AH AD - Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan. FAU - Azam, Kehkishan AU - Azam K AD - Dr. Ishrat-ul-Ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi-Pakistan. FAU - Malik, Sofia AU - Malik S AD - Dr. Ishrat-ul-Ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi-Pakistan. FAU - Amin, Muhammad AU - Amin M AD - Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Pakistan TA - J Ayub Med Coll Abbottabad JT - Journal of Ayub Medical College, Abbottabad : JAMC JID - 8910750 SB - IM MH - Double-Blind Method MH - Dry Socket/*epidemiology MH - Humans MH - Molar, Third/*surgery MH - Osteotomy MH - Postoperative Complications/*epidemiology MH - *Tooth Extraction/adverse effects/methods/statistics & numerical data MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - Alveolar Osteitis OT - Bone cutting OT - Mandibular third molar surgery EDAT- 2018/03/06 06:00 MHDA- 2018/08/08 06:00 CRDT- 2018/03/06 06:00 PHST- 2018/03/06 06:00 [entrez] PHST- 2018/03/06 06:00 [pubmed] PHST- 2018/08/08 06:00 [medline] AID - 3618/1868 [pii] PST - ppublish SO - J Ayub Med Coll Abbottabad. 2018 Jan-Mar;30(1):103-106. PMID- 9541344 OWN - NLM STAT- MEDLINE DCOM- 19980414 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 56 IP - 4 DP - 1998 Apr TI - Propofol and fentanyl compared with midazolam and fentanyl during third molar surgery. PG - 447-53; discussion 453-4 AB - PURPOSE: The purpose of this study was to measure the safety and efficacy of propofol combined with fentanyl as sedative agents during third molar outpatient surgery. PATIENTS AND METHODS: A double-blind, prospective, randomized clinical trial involving 57 patients undergoing removal of third molars under intravenous sedation between November 1994 and December 1995 was performed. Patients randomly received either propofol and fentanyl (P + F, th = 24) or midazolam and fentanyl (M + F, M = 33). Patient demographics, Corah anxiety scores, and physiologic parameters were determined preoperatively. All medications were titrated to the same clinical end point for sedation. Intraoperative physiologic parameters, cooperation, alertness, and pain scores were assessed. Postoperative recovery and degree of amnesia also were determined. RESULTS: There were no significant differences in either patient demographics or surgical characteristics between groups. The P + F group was significantly less cooperative than the M + F group. Pain during injection of propofol was a significant adverse side effect. Both groups experienced a small percentage of apneic episodes, but mechanical ventilation was never required. There were no differences in recovery between groups as measured by the Treiger dot test and psychomotor recovery scores. The degree of anterograde amnesia was greater for the M + F group, although the difference was not statistically significant. Sedation was rated good to excellent by the patient, surgeon, and observer, and there were no statistically significant differences between groups. CONCLUSION: Propofol appears to be a safe and efficacious drug for use during outpatient oral surgical procedures. FAU - Parworth, L P AU - Parworth LP AD - Department of Oral and Maxillofacial Surgery, University of North Carolina, Chapel Hill 27514-7450, USA. FAU - Frost, D E AU - Frost DE FAU - Zuniga, J R AU - Zuniga JR FAU - Bennett, T AU - Bennett T LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Combined) RN - 0 (Anesthetics, Intravenous) RN - R60L0SM5BC (Midazolam) RN - UF599785JZ (Fentanyl) RN - YI7VU623SF (Propofol) SB - AIM SB - D SB - IM CIN - J Oral Maxillofac Surg. 1999 Feb;57(2):219. PMID: 9973138 EIN - J Oral Maxillofac Surg. 1999 Feb;57(2):219. PMID: 9973138 MH - Adolescent MH - Adult MH - Anesthesia Recovery Period MH - Anesthesia, Dental/*methods MH - Anesthetics, Combined MH - *Anesthetics, Intravenous MH - Conscious Sedation/*methods MH - Double-Blind Method MH - Female MH - Fentanyl MH - Humans MH - Male MH - Manifest Anxiety Scale MH - *Midazolam MH - Molar, Third/*surgery MH - Pain Measurement MH - *Propofol MH - Prospective Studies MH - *Tooth Extraction EDAT- 1998/04/16 00:00 MHDA- 1998/04/16 00:01 CRDT- 1998/04/16 00:00 PHST- 1998/04/16 00:00 [pubmed] PHST- 1998/04/16 00:01 [medline] PHST- 1998/04/16 00:00 [entrez] AID - S0278-2391(98)90710-8 [pii] AID - 10.1016/s0278-2391(98)90710-8 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1998 Apr;56(4):447-53; discussion 453-4. doi: 10.1016/s0278-2391(98)90710-8. PMID- 28982352 OWN - NLM STAT- MEDLINE DCOM- 20180716 LR - 20181113 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 17 IP - 1 DP - 2017 Oct 5 TI - How effective is collagen resorbable membrane placement after partially impacted mandibular third molar surgery on postoperative morbidity? A prospective randomized comparative study. PG - 126 LID - 10.1186/s12903-017-0416-z [doi] LID - 126 AB - BACKGROUND: Collagen membranes have some benefits include promoting wound healing through isolation, clot stabilization, wound stability, and hemostasis, enhancing primary wound coverage through its chemotactic ability to attract fibroblasts, and augmenting flap thickness by providing a collagenous scaffold. The purpose of this study was to compare primary and secondary healing and collagen membrane-based primary healing after surgical removal of partial impacted mandibular third molars, evaluating the incidence of postoperative complications and analyzing the swelling, mouth opening, and pain. METHODS: This was a prospective, randomized controlled study. Patients were randomly assigned to three groups: the SC (Secondary closure) group, the PC (Primary closure) group, and the MBPC (membrane based primary closure) group. Data were collected on pain, mouth opening, swelling, and complications experienced by the patients. RESULTS: There was no statistically significant difference between the groups for the pain (p > 0.05), relatively. The swelling recorded on postoperative days 2 and 7 was lower in the SC group than in the PC (p = 0.046 and 0.00) and in MBPC (p = 0.005 and 0.002) groups, respectively. Mouth opening showed a statistically significant difference between the three groups at day 2 (p = 0.00). Wound dehiscence was shown in 6 patients in the PC (20%) group and 2 patients in the MBPC (6.7%) group. Dry socket was observed 3 patients in the SC group (10%), 2 patients in the PC group (6.7%), and no dry socket in the MBPC group. No cases of infection or postoperative bleeding were encountered. CONCLUSIONS: The secondary closure provides a marked advantage over the primary closure in terms of swelling and mouth opening. However, the absence of alveolitis in the primary closure using the collagen membrane and minimal wound dehiscence, suggests that membrane use may support primary healing in terms of wound healing. FAU - Kilinc, Adnan AU - Kilinc A AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, 25240, Erzurum, Turkey. adnankilin@yahoo.com. FAU - Ataol, Mert AU - Ataol M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, 25240, Erzurum, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20171005 TA - BMC Oral Health JT - BMC oral health JID - 101088684 RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) SB - D SB - IM MH - Biocompatible Materials/*administration & dosage MH - Collagen/*administration & dosage MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - *Wound Closure Techniques MH - Wound Healing MH - Young Adult PMC - PMC5629786 OTO - NOTNLM OT - Collagen resorbable membrane OT - Mandibular third molar surgery OT - Partially impacted tooth OT - Postoperative morbidity COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was carried out at the Department of the Oral and Maxillofacial Surgery of the Ataturk University Faculty of Dentistry (Erzurum, Turkey). This study followed the Declaration of Helsinki on medical protocol and ethics and the regional Ethical Review Board of Ataturk University Faculty of Dentistry approved the study, and informed consent was obtained from all patients or parents or legal guardians. Informed consent to participate was obtained in writing from participants after explaining the study purposes, methodology and possible future publication of clinical datasets. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2017/10/07 06:00 MHDA- 2018/07/17 06:00 CRDT- 2017/10/07 06:00 PHST- 2017/03/30 00:00 [received] PHST- 2017/09/25 00:00 [accepted] PHST- 2017/10/07 06:00 [entrez] PHST- 2017/10/07 06:00 [pubmed] PHST- 2018/07/17 06:00 [medline] AID - 10.1186/s12903-017-0416-z [pii] AID - 416 [pii] AID - 10.1186/s12903-017-0416-z [doi] PST - epublish SO - BMC Oral Health. 2017 Oct 5;17(1):126. doi: 10.1186/s12903-017-0416-z. PMID- 10425809 OWN - NLM STAT- MEDLINE DCOM- 19990804 LR - 20190719 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 186 IP - 12 DP - 1999 Jun 26 TI - The effect of tranexamic acid (cyclokapron) on blood loss after third molar extraction under a day case general anaesthetic. PG - 634-6 AB - OBJECTIVE: To evaluate the effect of pre-operative administration of tranexamic acid in preventing prolonged post-operative bleeding in day-case patients. Day-case admission is highly appropriate for dentoalveolar surgery but one of the problems is prolonged post-operative haemorrhage which at times may delay discharge or necessitate readmission to hospital. Tranexamic acid has traditionally been used to treat post-operative bleeding. DESIGN: A prospective double-blind randomised study. SETTING: Eastman Dental Hospital, London. SUBJECTS AND METHODS: Fifty-six patients were consecutively selected from healthy adult volunteers who were having third molar extraction in the day case unit of the Eastman Dental Hospital over a period of 22 weeks. Tranexamic acid (25 mg/kg) or normal saline was administered intravenously at induction by the anaesthetist and blood loss was measured intra- and post-operatively. RESULTS: A significant reduction (P = 0.023) in the post-operative blood loss was found in the tranexamic acid group. However, there was no significant difference in the intra-operative (P = 0.4) and the overall total blood loss (P = 0.21). No patient receiving tranexamic acid required readmission to control prolonged bleeding, or suffered any side effects from the drug. CONCLUSION: This study has shown that one intravenous pre-operative dose of tranexamic acid is effective in preventing excessive post-operative bleeding in patients undergoing third molar extraction under a day case general anaesthetic and therefore facilitates safe discharge from hospital. FAU - Senghore, N AU - Senghore N AD - Department of Oral and Maxillofacial Surgery, Eastman Dental Institute and Hospital, London. FAU - Harris, M AU - Harris M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Antifibrinolytic Agents) RN - 6T84R30KC1 (Tranexamic Acid) SB - D SB - IM MH - Adolescent MH - Adult MH - Ambulatory Surgical Procedures/*adverse effects MH - Anesthesia, Dental MH - Anesthesia, General MH - Antifibrinolytic Agents/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intravenous MH - Male MH - Molar, Third/*surgery MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Premedication MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tranexamic Acid/*administration & dosage EDAT- 1999/07/30 00:00 MHDA- 1999/07/30 00:01 CRDT- 1999/07/30 00:00 PHST- 1999/07/30 00:00 [pubmed] PHST- 1999/07/30 00:01 [medline] PHST- 1999/07/30 00:00 [entrez] AID - 10.1038/sj.bdj.4800183 [doi] PST - ppublish SO - Br Dent J. 1999 Jun 26;186(12):634-6. doi: 10.1038/sj.bdj.4800183. PMID- 25488309 OWN - NLM STAT- MEDLINE DCOM- 20150329 LR - 20150112 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 2 DP - 2015 Feb TI - A prospective randomized controlled trial of two different sedation sequences for third molar removal in adults. PG - 224-31 LID - S0278-2391(14)01405-0 [pii] LID - 10.1016/j.joms.2014.08.033 [doi] AB - PURPOSE: In oral and maxillofacial outpatient surgery, sedation techniques are an important component in patient management for a wide variety of surgical procedures. Fentanyl and midazolam are commonly used sedatives with different mechanisms of action and specific analgesic or amnestic properties. This study examined whether the order of their administration would affect a patient's pain perception or procedural vital signs. MATERIALS AND METHODS: After institutional review board approval and written informed consent, a prospective, randomized, parallel-group clinical trial was conducted in patients who planned to undergo removal of at least 2 third molars under intravenous moderate sedation. Patients were randomly assigned to 1 of 2 groups. The fentanyl-first group received fentanyl and then midazolam; the midazolam-first group received midazolam and then fentanyl. Recollection of the intraoperative pain score was assessed 24 hours after surgery using the Wong-Baker FACES pain scale. The Mann-Whitney U test was used to assess for the presence of a statistically significant difference between the 2 groups. Statistically significant differences in procedural vital sign fluctuations were examined using the t test. Patients' satisfaction with the procedure was assessed and intergroup comparisons were made. RESULTS: Sixty-six patients were enrolled, 1 of whom did not complete the study. Recollected procedural pain scores at 24 hours after surgery were not statistically different between groups. Median scores on the Wong-Baker FACES pain scale for the 2 groups were 2.0 (interquartile range, 3.1) for the fentanyl-first group and 1.5 (interquartile range, 2.5) for the midazolam-first group (P = .333). There was no statistical difference in the change in vital signs from baseline to 2 surgical end points in the 2 groups. In addition, patient satisfaction with the procedure did not statistically differ between the 2 groups. CONCLUSIONS: In this study, selective sequencing of midazolam or fentanyl during an intravenous moderate-sedation procedure did not result in a measurable difference of recollected procedural pain scores at 24 hours after third molar extraction. The choice of the sedation agents and the order of their administration should be tailored to the patient's needs, type of surgical procedure, and surgeon preference. CI - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Khader, Ruba AU - Khader R AD - Assistant Professor, Division of Oral and Maxillofacial Surgery, Medical College of Wisconsin, Milwaukee, WI. Electronic address: rubakhader@gmail.com. FAU - Oreadi, Daniel AU - Oreadi D AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, MA. FAU - Finkelman, Matthew AU - Finkelman M AD - Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA. FAU - Jarmoc, Marcin AU - Jarmoc M AD - Clinical Instructor, Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, MA; Oral and Maxillofacial Surgeon, Northern Star Dental Group, Danvers, MA. FAU - Chaudhary, Sanjeet AU - Chaudhary S AD - Resident, Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, MA. FAU - Schumann, Roman AU - Schumann R AD - Professor, Vice Chair of Academic Affairs, Department of Anesthesiology, Tufts Medical Center; Vice-Chair, Tufts University Health Sciences Institutional Review Board; Professor, Vice Chair of Academic Affairs, Department of Anesthesiology, Tufts Medical Center; Professor, Tufts University School of Medicine, Boston, MA. FAU - Rosenberg, Morton AU - Rosenberg M AD - Professor, Department of Oral and Maxillofacial Surgery; Head, Division of Anesthesia and Pain Control, Tufts University School of Dental Medicine; Associate Professor, Department of Anesthesiology, Tufts University School of Medicine, Boston, MA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20140916 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Hypnotics and Sedatives) SB - AIM SB - D SB - IM MH - Humans MH - Hypnotics and Sedatives/*administration & dosage MH - Molar, Third/*surgery MH - Prospective Studies MH - *Tooth Extraction EDAT- 2014/12/10 06:00 MHDA- 2015/03/31 06:00 CRDT- 2014/12/10 06:00 PHST- 2014/05/09 00:00 [received] PHST- 2014/08/21 00:00 [revised] PHST- 2014/08/24 00:00 [accepted] PHST- 2014/12/10 06:00 [entrez] PHST- 2014/12/10 06:00 [pubmed] PHST- 2015/03/31 06:00 [medline] AID - S0278-2391(14)01405-0 [pii] AID - 10.1016/j.joms.2014.08.033 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Feb;73(2):224-31. doi: 10.1016/j.joms.2014.08.033. Epub 2014 Sep 16. PMID- 32673573 OWN - NLM STAT- MEDLINE DCOM- 20201110 LR - 20201112 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 11 DP - 2020 Nov TI - Comparison of Surgical Drain Placement With Use of Kinesiologic Tape on Postoperative Pain, Swelling, and Trismus in Impacted Mandibular Third Molar Surgery. PG - 1919.e1-1919.e7 LID - S0278-2391(20)30666-2 [pii] LID - 10.1016/j.joms.2020.06.023 [doi] AB - PURPOSE: The aim of this prospective study was to compare the effects of a surgical tube drain with kinesiologic tape (KT) application on postoperative complications such as trismus, swelling, and pain after impacted third molar surgery. PATIENTS AND METHODS: This single-center, randomized study included 90 patients divided into 3 groups. After impacted third molar removal, 30 patients were treated with a tube drain (drain group), 30 patients were treated with KT application (KT group), and 30 patients were treated with a routine surgical operation and no extra procedure (control group). RESULTS: A total of 29 male and 61 female patients were included. Mouth opening was greatest in the drain group over a period of 7 days. Patients in the control group had more pain than those in the drain and KT groups. No statistically significant difference was found in terms of pain and swelling between the drain and KT groups over the 7-day period of the study. The tube drain was found to improve patients' quality-of-life compared with the KT and control groups. CONCLUSIONS: Although the effects of a tube drain and KT in terms of pain and swelling were similar, the tube drain was more effective in reducing postoperative complications. CI - Copyright © 2020 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Menziletoglu, Dilek AU - Menziletoglu D AD - Assistant Professor, Faculty of Dentistry, Oral and Maxillofacial Surgery, Necmettin Erbakan University, Konya, Turkey. Electronic address: drdilekmenziletoglu@gmail.com. FAU - Guler, Arif Yigit AU - Guler AY AD - Research Assistant, Faculty of Dentistry, Oral and Maxillofacial Surgery, Necmettin Erbakan University, Konya, Turkey. FAU - Basturk, Funda AU - Basturk F AD - Research Assistant, Faculty of Dentistry, Oral and Maxillofacial Surgery, Necmettin Erbakan University, Konya, Turkey. FAU - Isik, Bozkurt Kubilay AU - Isik BK AD - Professor and Department Head, Faculty of Dentistry, Oral and Maxillofacial Surgery, Necmettin Erbakan University, Konya, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200622 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/prevention & control MH - Prospective Studies MH - Tooth Extraction MH - *Tooth, Impacted/surgery MH - *Trismus/etiology/prevention & control EDAT- 2020/07/17 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/07/17 06:00 PHST- 2020/02/07 00:00 [received] PHST- 2020/05/01 00:00 [revised] PHST- 2020/06/15 00:00 [accepted] PHST- 2020/07/17 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/07/17 06:00 [entrez] AID - S0278-2391(20)30666-2 [pii] AID - 10.1016/j.joms.2020.06.023 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Nov;78(11):1919.e1-1919.e7. doi: 10.1016/j.joms.2020.06.023. Epub 2020 Jun 22. PMID- 24880449 OWN - NLM STAT- MEDLINE DCOM- 20150710 LR - 20190609 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 19 IP - 6 DP - 2014 Nov 1 TI - Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars. PG - e612-5 AB - OBJECTIVE: The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications. STUDY DESIGN: The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake. RESULTS: From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences between the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications (p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication. CONCLUSION: The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort. FAU - Iglesias-Martín, Fernando AU - Iglesias-Martín F AD - Facultad de Odontología de Sevilla, C/ Avicena s/n 41009, Sevilla (SPAIN), danieltl@us.es. FAU - García-Perla-García, Alberto AU - García-Perla-García A FAU - Yañez-Vico, Rosa AU - Yañez-Vico R FAU - Aced-Jiménez, Elena AU - Aced-Jiménez E FAU - Arjona-Gerveno, Esther AU - Arjona-Gerveno E FAU - González-Padilla, Juan-David AU - González-Padilla JD FAU - Gutierrez-Pérez, Jose-Luis AU - Gutierrez-Pérez JL FAU - Torres-Lagares, Daniel AU - Torres-Lagares D LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20141101 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Anti-Bacterial Agents) RN - 0 (beta-Lactamase Inhibitors) RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) RN - 804826J2HU (Amoxicillin) SB - D SB - IM MH - Adult MH - Amoxicillin/*therapeutic use MH - Amoxicillin-Potassium Clavulanate Combination/*therapeutic use MH - Anti-Bacterial Agents/*therapeutic use MH - Bacterial Infections/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Postoperative Complications/*prevention & control MH - *Tooth Extraction MH - beta-Lactamase Inhibitors/*therapeutic use PMC - PMC4259379 EDAT- 2014/06/02 06:00 MHDA- 2015/07/15 06:00 CRDT- 2014/06/02 06:00 PHST- 2013/12/31 00:00 [received] PHST- 2014/03/31 00:00 [accepted] PHST- 2014/06/02 06:00 [entrez] PHST- 2014/06/02 06:00 [pubmed] PHST- 2015/07/15 06:00 [medline] AID - 19778 [pii] AID - 10.4317/medoral.19778 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2014 Nov 1;19(6):e612-5. doi: 10.4317/medoral.19778. PMID- 22695015 OWN - NLM STAT- MEDLINE DCOM- 20121024 LR - 20181201 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 70 IP - 8 DP - 2012 Aug TI - Secondary versus primary closure techniques for the prevention of postoperative complications following removal of impacted mandibular third molars: a systematic review and meta-analysis of randomized controlled trials. PG - e441-57 LID - 10.1016/j.joms.2012.03.017 [doi] AB - PURPOSE: To determine the impact of secondary versus primary closure techniques on the frequency and severity of pain, facial swelling, trismus, infectious complications, and postoperative bleeding after impacted mandibular third molar extraction. MATERIALS AND METHODS: Randomized controlled trials were identified through MEDLINE, EMBASE, and CENTRAL, ongoing trial registers, meeting abstracts, doctoral and masters theses, and manual searching of the reference lists of eligible studies. Study selection, data extraction, risk of bias, and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) rating of confidence in effect estimates were undertaken independently in duplicate. RESULTS: Of 1,721 identified citations, 14 studies proved eligible. Pain and facial swelling at postoperative days 3 and 7 and infectious complications at day 7 did not differ between techniques. Patients receiving secondary closure had less trismus (in millimeters) at postoperative days 3 (mean difference, 3.72; 95% confidence interval, 1.42 to 6.03, P = .002) and 7 (mean difference, 2.35; 95% confidence interval, 0.37 to 4.33; P = .02). Four randomized controlled trials reported bleeding: in 2, there was no bleeding in either group; the numbers of bleeding events with primary and secondary closures were 22 and 16 and 5 and 15, respectively, in the other 2. Because of the risk of bias and inconsistency in results, the evidence warranted, at best, low confidence in the estimates of effect across all outcomes. CONCLUSIONS: Although differences between primary and secondary closure techniques after impacted mandibular third molar extraction are likely to be small, available evidence provides only low confidence in the effect estimates. The results do not support a preference for either approach. CI - Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Carrasco-Labra, Alonso AU - Carrasco-Labra A AD - Department of Oral and Maxillofacial Surgery and Evidence-Based Dentistry Unit, Faculty of Dentistry, Universidad de Chile, Santiago, Chile. alonsocarrascolabra@gmail.com FAU - Brignardello-Petersen, Romina AU - Brignardello-Petersen R FAU - Yanine, Nicolás AU - Yanine N FAU - Araya, Ignacio AU - Araya I FAU - Guyatt, Gordon AU - Guyatt G LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20120612 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Edema/prevention & control MH - Humans MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Postoperative Hemorrhage/prevention & control MH - *Randomized Controlled Trials as Topic MH - Surgical Wound Infection/prevention & control MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - *Wound Closure Techniques EDAT- 2012/06/15 06:00 MHDA- 2012/10/25 06:00 CRDT- 2012/06/15 06:00 PHST- 2012/02/11 00:00 [received] PHST- 2012/03/06 00:00 [accepted] PHST- 2012/06/15 06:00 [entrez] PHST- 2012/06/15 06:00 [pubmed] PHST- 2012/10/25 06:00 [medline] AID - S0278-2391(12)00386-2 [pii] AID - 10.1016/j.joms.2012.03.017 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2012 Aug;70(8):e441-57. doi: 10.1016/j.joms.2012.03.017. Epub 2012 Jun 12. PMID- 24326812 OWN - NLM STAT- MEDLINE DCOM- 20140220 LR - 20140731 IS - 1119-3077 (Print) VI - 17 IP - 1 DP - 2014 Jan-Feb TI - Effects of the topical hemostatic agent Ankaferd Blood Stopper on the incidence of alveolar osteitis after surgical removal of an impacted mandibular third molar. PG - 75-80 LID - 10.4103/1119-3077.122847 [doi] AB - BACKGROUND: Alveolar osteitis (AO) is a commonly seen post-operative complication during the wound-healing period after permanent tooth extraction or surgical removal of impacted third molar teeth. OBJECTIVES: The aim of this clinical study was to evaluate the effects of administration of the topical hemostatic agent Ankaferd Blood Stopper (ABS) into the socket on AO formation after impacted mandibular third molar extraction. PATIENTS AND METHODS: Bilaterally, 100 half-impacted mandibular third molars were extracted in 50 patients. Then, 1.0 mL ABS was administered to achieve hemostasis in one half of the sockets and as a control, the other half was irrigated with 1.0 mL physiological serum after surgery. RESULTS: There was no statistically significant difference in terms of AO formation ( P > 0.05) between the extraction sites. However, the postoperative pain in ABS administration sites was higher than in the other sites for the first 2 days after surgery ( P < 0.05). CONCLUSIONS: The results showed that ABS administration did not increase the incidence of AO formation. Thus, ABS can be used safely for hemostasis after impacted mandibular third molar surgery. FAU - Tek, M AU - Tek M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Abant Izzet Baysal University, Bolu, Turkey. FAU - Akkas, I AU - Akkas I FAU - Toptas, O AU - Toptas O FAU - Ozan, F AU - Ozan F FAU - Sener, I AU - Sener I FAU - Bereket, C AU - Bereket C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 RN - 0 (Plant Extracts) RN - 0 (ankaferd blood stopper) SB - IM MH - Administration, Topical MH - Adolescent MH - Adult MH - Double-Blind Method MH - Dry Socket/*epidemiology/etiology/prevention & control MH - Female MH - Follow-Up Studies MH - *Hemostatic Techniques MH - Humans MH - Incidence MH - Male MH - Molar, Third/*surgery MH - Plant Extracts/*administration & dosage MH - Prospective Studies MH - Surgical Wound Infection/*epidemiology/etiology/prevention & control MH - Tooth Extraction/*adverse effects/methods MH - Tooth, Impacted/microbiology/*surgery MH - Turkey/epidemiology MH - Wound Healing MH - Young Adult EDAT- 2013/12/12 06:00 MHDA- 2014/02/22 06:00 CRDT- 2013/12/12 06:00 PHST- 2013/12/12 06:00 [entrez] PHST- 2013/12/12 06:00 [pubmed] PHST- 2014/02/22 06:00 [medline] AID - NigerJClinPract_2014_17_1_75_122847 [pii] AID - 10.4103/1119-3077.122847 [doi] PST - ppublish SO - Niger J Clin Pract. 2014 Jan-Feb;17(1):75-80. doi: 10.4103/1119-3077.122847. PMID- 25882437 OWN - NLM STAT- MEDLINE DCOM- 20151117 LR - 20181202 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 9 DP - 2015 Sep TI - Orthodontic Extraction of High-Risk Impacted Mandibular Third Molars in Close Proximity to the Mandibular Canal: A Systematic Review. PG - 1672-85 LID - S0278-2391(15)00282-7 [pii] LID - 10.1016/j.joms.2015.03.031 [doi] AB - PURPOSE: Extraction of mandibular third molars (M3s) in close proximity to the mandibular canal has some inherent risks to adjacent structures, such as neurologic damage to teeth, bone defects distal to the mandibular second molar (M2), or pathologic fractures in association with enlarged dentigerous cysts. The procedure for extrusion and subsequent extraction of high-risk M3s is called orthodontic extraction. This is a systematic review of the available approaches for orthodontic extraction of impacted mandibular M3s in close proximity to the mandibular canal and their outcomes. MATERIALS AND METHODS: The PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), DOAJ, Google Scholar, OpenGrey, Iranian Science Information Database (SID), Iranmedex, and Irandoc databases were searched using specific keywords up to June 2, 2014. Studies were evaluated based on predetermined eligibility criteria, treatment approaches, and their outcomes. RESULTS: Thirteen articles met the inclusion criteria. A total of 123 impacted teeth were extracted by orthodontic extraction and 2 cases were complicated by transient paresthesia. Three types of biomechanical approaches were used: 1) using the posterior maxillary region as the anchor for orthodontic extrusion of lower M3s, 2) simple cantilever springs attached to the M3 buttonhole, and 3) cantilever springs tied to a bonded orthodontic bracket on the M3 plus multiple-loop spring wire for distal movement of the M3. Osteo-periodontal status of M2s also improved uneventfully. CONCLUSION: Despite the drawbacks of orthodontic extraction, removal of deeply impacted M3s using the described techniques is safe with regard to mandibular nerve injury and neurologic damage. Orthodontic extraction is recommended for extraction of impacted M3s that present a high risk of postoperative osteo-periodontal defects on the distal surface of the adjacent M2 and those associated with dentigerous cysts. CI - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Kalantar Motamedi, Mahmood Reza AU - Kalantar Motamedi MR AD - Scientific Researcher, Department of Orthodontics, School of Dentistry, Isfahan Branch, Islamic Azad University, Isfahan, Iran. FAU - Heidarpour, Majid AU - Heidarpour M AD - Assistant Professor, Dental Materials Research Center, and Department of Orthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Siadat, Sara AU - Siadat S AD - Postgraduate Student, Department of Orthodontics, School of Dentistry, Isfahan Branch, Islamic Azad University, Isfahan, Iran. FAU - Kalantar Motamedi, Alimohammad AU - Kalantar Motamedi A AD - Assistant Professor, Department of Orthodontics, School of Dentistry, Isfahan Branch, Islamic Azad University, Isfahan, Iran. Electronic address: a_motamedi@hotmail.com. FAU - Bahreman, Ali Akbar AU - Bahreman AA AD - Clinical Professor, Orthodontic and Pediatric Dentistry Programs, Eastman Institute for Oral Health, University of Rochester, NY. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20150324 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Humans MH - Mandible/*surgery MH - Molar, Third/*surgery MH - *Orthodontics MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2015/04/18 06:00 MHDA- 2015/11/18 06:00 CRDT- 2015/04/18 06:00 PHST- 2014/09/13 00:00 [received] PHST- 2015/03/07 00:00 [revised] PHST- 2015/03/09 00:00 [accepted] PHST- 2015/04/18 06:00 [entrez] PHST- 2015/04/18 06:00 [pubmed] PHST- 2015/11/18 06:00 [medline] AID - S0278-2391(15)00282-7 [pii] AID - 10.1016/j.joms.2015.03.031 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Sep;73(9):1672-85. doi: 10.1016/j.joms.2015.03.031. Epub 2015 Mar 24. PMID- 24762895 OWN - NLM STAT- MEDLINE DCOM- 20160419 LR - 20181202 IS - 1476-5373 (Electronic) IS - 0007-0610 (Linking) VI - 216 IP - 8 DP - 2014 Apr TI - Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth, a Cochrane systematic review. PG - 451-5 LID - 10.1038/sj.bdj.2014.330 [doi] AB - This paper compares the beneficial and harmful effects of paracetamol, ibuprofen and the novel combination of both in a single tablet for pain relief following the surgical removal of lower wisdom teeth. In this systematic review only randomised controlled double-blinded clinical trials were included. We calculated the proportion of patients with at least 50% pain relief at 2 and 6 hours post dosing, along with the proportion of participants using rescue medication at 6 and 8 hours. Adverse events were also analysed. Data was meta-analysed where possible. Seven studies were included with a total of 2,241 participants enrolled. Ibuprofen 400 mg is superior to 1,000 mg paracetamol with a risk ratio for at least 50% pain relief at 6 hours of 1.47 (95% confidence interval [CI] 1.28 to 1.69). For the combined drug, the risk ratio for at least 50% maximum pain relief over 6 hours is 1.77 (95% CI 1.32 to 2.39) based on total pain relief (TOTPAR) data. There is high quality evidence that ibuprofen is superior to paracetamol. The novel combination drug shows encouraging results when compared to the single drugs (based on two trials). FAU - Bailey, E AU - Bailey E AD - University of Manchester, School of Dentistry, Higher Cambridge Street, Manchester, M13 9PL. FAU - Worthington, H AU - Worthington H AD - University of Manchester, School of Dentistry, Higher Cambridge Street, Manchester, M13 9PL. FAU - Coulthard, P AU - Coulthard P AD - University of Manchester, School of Dentistry, Higher Cambridge Street, Manchester, M13 9PL. LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Analgesics, Non-Narcotic/administration & dosage/*therapeutic use MH - Drug Therapy, Combination MH - Humans MH - Ibuprofen/administration & dosage/*therapeutic use MH - Molar, Third/*surgery MH - Pain Management/*methods MH - Tooth Extraction/*methods EDAT- 2014/04/26 06:00 MHDA- 2016/04/20 06:00 CRDT- 2014/04/26 06:00 PHST- 2014/02/18 00:00 [accepted] PHST- 2014/04/26 06:00 [entrez] PHST- 2014/04/26 06:00 [pubmed] PHST- 2016/04/20 06:00 [medline] AID - sj.bdj.2014.330 [pii] AID - 10.1038/sj.bdj.2014.330 [doi] PST - ppublish SO - Br Dent J. 2014 Apr;216(8):451-5. doi: 10.1038/sj.bdj.2014.330. PMID- 18022350 OWN - NLM STAT- MEDLINE DCOM- 20080219 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 36 IP - 12 DP - 2007 Dec TI - A blinded randomized controlled trial comparing lignocaine and placebo administration to the palate for removal of maxillary third molars. PG - 1177-82 AB - Routine use of a palatal injection for the removal of maxillary third molars has never been validated. The purpose of this blinded, randomized, controlled trial was to assess the requirement of a separate palatal injection for the extraction of maxillary third molars. Fifty-one patients requiring the removal of bilateral maxillary third molars were enrolled. Each patient acting as their own control received buccal infiltrations of lignocaine bilaterally, then 0.2 mL of lignocaine without vasoconstrictor was administered to one side of the palate and the same amount of normal saline administered to the other side. Sides were randomized as to the active ingredient and both the patient and operator were blinded. All extractions were performed by a single operator using a consistent technique and no additional sedative or anaesthetic agents were utilized. Data relating to the pain of the extractions and of the palatal injection were obtained on a Visual Analogue Scale (VAS). Verbal Response Scale (VRS) data were obtained additionally for a subset of 21 patients. Statistical analysis confirmed clinical equivalence between saline and lignocaine to the palate (95% CI -1.7 to 6.2mm, equivalence range -6.75 to 6.75 mm). No patients requested additional lignocaine to the palate in order to ensure comfortable extraction. This study provides evidence that the poorly tolerated palatal injection of local anaesthetic for the removal of maxillary third molars may not be required. FAU - Badcock, M E AU - Badcock ME AD - School of Dental Science, University of Melbourne, 720 Swanston Street, Parkville, Vic. 3010, Australia; Private Practice, Melbourne, Australia. markbadcock@oralsurgery.net.au FAU - Gordon, I AU - Gordon I FAU - McCullough, M J AU - McCullough MJ LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20071119 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthetics, Local/*administration & dosage MH - Epidemiologic Methods MH - Female MH - Humans MH - Lidocaine/*administration & dosage MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Palate/*drug effects MH - Toothache/*drug therapy/prevention & control EDAT- 2007/11/21 09:00 MHDA- 2008/02/20 09:00 CRDT- 2007/11/21 09:00 PHST- 2007/03/02 00:00 [received] PHST- 2007/06/04 00:00 [accepted] PHST- 2007/11/21 09:00 [pubmed] PHST- 2008/02/20 09:00 [medline] PHST- 2007/11/21 09:00 [entrez] AID - S0901-5027(07)00206-8 [pii] AID - 10.1016/j.ijom.2007.06.001 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2007 Dec;36(12):1177-82. doi: 10.1016/j.ijom.2007.06.001. Epub 2007 Nov 19. PMID- 24268907 OWN - NLM STAT- MEDLINE DCOM- 20150810 LR - 20141203 IS - 1578-8989 (Electronic) IS - 0025-7753 (Linking) VI - 143 IP - 11 DP - 2014 Dec 9 TI - [Tranexamic acid gel in patients treated with oral anticoagulants]. PG - 484-8 LID - S0025-7753(13)00652-0 [pii] LID - 10.1016/j.medcli.2013.07.028 [doi] AB - BACKGROUND AND OBJECTIVE: Patients treated with oral anticoagulants have increased susceptibility to bleeding, and therefore any surgical medical procedure and especially oral surgery requires a therapeutic approach that minimizes bleeding effects in these patients. MATERIAL AND METHOD: The working hypothesis was based on studies of local application of tranexamic acid after maxillofacial interventions as effective therapeutic alternative for the prevention and control of bleeding. The aim was to assess the effectiveness of the application of a gel solution tranexamic acid after tooth extraction in anticoagulated patients in terms of healing time and degree of healing. RESULTS: The results indicate that application of tranexamic acid gel is very effective for consistency and maintenance in the place of action and shows its efficacy as a procoagulant material. CONCLUSIONS: The application of a gel solution of tranexamic acid in oral anticoagulants patients ameliorates healing time and the bleeding time within the first 48-72 h. CI - Copyright © 2013 Elsevier España, S.L.U. All rights reserved. FAU - Ripollés-de Ramón, Jorge AU - Ripollés-de Ramón J AD - Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, España. Electronic address: jorgeripolles@hotmail.com. FAU - Muñoz-Corcuera, Marta AU - Muñoz-Corcuera M AD - Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, España. FAU - Bravo-Llatas, Carmen AU - Bravo-Llatas C AD - Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, España. FAU - Bascones-Martínez, Antonio AU - Bascones-Martínez A AD - Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, España. LA - spa PT - Comparative Study PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Aplicación de un gel de ácido tranexámico en pacientes tratados con anticoagulantes orales. DEP - 20131121 PL - Spain TA - Med Clin (Barc) JT - Medicina clinica JID - 0376377 RN - 0 (Anticoagulants) RN - 0 (Antifibrinolytic Agents) RN - 0 (Gels) RN - 6T84R30KC1 (Tranexamic Acid) RN - I6WP63U32H (Acenocoumarol) SB - IM MH - Acenocoumarol/*adverse effects/therapeutic use MH - Anticoagulants/*adverse effects/therapeutic use MH - Antifibrinolytic Agents/administration & dosage/*therapeutic use MH - Gels MH - Humans MH - Postoperative Hemorrhage/chemically induced/*drug therapy/etiology MH - Tooth Extraction MH - Tranexamic Acid/administration & dosage/*therapeutic use MH - Treatment Outcome MH - Wound Healing OTO - NOTNLM OT - Anticoagulantes orales OT - Dental extraction OT - Exodoncia OT - Oral anticoagulants OT - Tranexamic acid OT - Ácido tranexámico EDAT- 2013/11/26 06:00 MHDA- 2015/08/11 06:00 CRDT- 2013/11/26 06:00 PHST- 2013/04/09 00:00 [received] PHST- 2013/07/10 00:00 [revised] PHST- 2013/07/15 00:00 [accepted] PHST- 2013/11/26 06:00 [entrez] PHST- 2013/11/26 06:00 [pubmed] PHST- 2015/08/11 06:00 [medline] AID - S0025-7753(13)00652-0 [pii] AID - 10.1016/j.medcli.2013.07.028 [doi] PST - ppublish SO - Med Clin (Barc). 2014 Dec 9;143(11):484-8. doi: 10.1016/j.medcli.2013.07.028. Epub 2013 Nov 21. PMID- 20614049 OWN - NLM STAT- MEDLINE DCOM- 20101029 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 41 IP - 7 DP - 2010 Jul-Aug TI - Ridge preservation following tooth extraction: a comparison between atraumatic extraction and socket seal surgery. PG - 605-9 AB - OBJECTIVE: To evaluate whether alveolar ridge resorption following tooth extraction could be prevented or reduced using absorbable collagen material impregnated with gentamicin and sealed with an autogenous soft tissue graft to stabilize the extraction clot, and to compare this with natural healing by clot formation using a classic extraction technique. METHOD AND MATERIALS: A total of 125 patients providing 173 extraction sites were included in the study. Three extraction protocols were compared: atraumatic extraction (group A, n = 101 extraction sites), atraumatic extraction sealing the socket with autogenous soft tissue graft (group B, n = 39), and atraumatic extraction with socket seal surgery and collagen matrix impregnated with gentamicin (group C, n = 33). Silicone impressions were made before and 3 months after extraction. Casts were used to measure the width of the alveolar bone at the extraction area using the incisal edge of the adjacent teeth as a reference point. RESULTS: The clinical measurement 3 months after extraction revealed a loss of bone width of 0.3 +/- 0.5 mm in group A, 0.8 +/- 0.7 mm in group B, and 0.1 +/- 0.1 mm in group C. There was no significant difference in bone resorption in extraction sites among the groups (P > .05). However, the difference between group A and group C was borderline significant (P = .07). After 10 days, 31 grafts from group C and 30 grafts from group B remained vital. CONCLUSIONS: It seems that extraction technique affects alveolar bone resorption, regardless of whether the socket is treated with free gingival graft or bone graft. Further, the local application of gentamicin presented more vascular ingrowth in the blood clot and granulation tissue beneath the graft, thereby supplying better nourishment during the initial healing phase of the graft. FAU - Oghli, Ayham Arab AU - Oghli AA AD - aaogli@hotmail.com FAU - Steveling, Helmut AU - Steveling H LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 RN - 0 (Anti-Bacterial Agents) RN - 0 (Gentamicins) RN - 9007-34-5 (Collagen) SB - D MH - Absorbable Implants MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Alveolar Bone Loss/*prevention & control MH - Alveolar Process/*pathology MH - Anti-Bacterial Agents/administration & dosage/therapeutic use MH - Blood Coagulation MH - Collagen/therapeutic use MH - Dental Impression Technique MH - Female MH - Follow-Up Studies MH - Gentamicins/administration & dosage/therapeutic use MH - Gingiva/*transplantation MH - Humans MH - Male MH - Middle Aged MH - Tooth Extraction/*methods MH - Tooth Socket/*surgery MH - Wound Healing/physiology MH - Young Adult EDAT- 2010/07/09 06:00 MHDA- 2010/10/30 06:00 CRDT- 2010/07/09 06:00 PHST- 2010/07/09 06:00 [entrez] PHST- 2010/07/09 06:00 [pubmed] PHST- 2010/10/30 06:00 [medline] AID - 840294 [pii] PST - ppublish SO - Quintessence Int. 2010 Jul-Aug;41(7):605-9. PMID- 20117915 OWN - NLM STAT- MEDLINE DCOM- 20100518 LR - 20201209 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 39 IP - 2 DP - 2010 Feb TI - Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique. PG - 107-14 LID - 10.1016/j.ijom.2009.12.014 [doi] AB - The use of prophylactic antibiotics to reduce postoperative complications in third molar surgery remains controversial. The study was a prospective, randomized, double blind, placebo-controlled clinical trial. 100 patients were randomly assigned to two groups. Each patient acted as their own control using the split-mouth technique. Two unilateral impacted third molars were removed under antibiotic cover and the other two were removed without antibiotic cover. The first group received antibiotics on the first surgical visit. On the second surgical visit (after 3 weeks), placebo capsules were given or vice versa. The second group received antibiotics with continued therapy for 2 days on the first surgical visit and on the second surgical visit (after 3 weeks) placebo capsules were given or vice versa. Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery. Of 380 impactions, 6 sockets (2%) became infected. There was no statistically significant difference in the infection rate, pain, swelling, trismus, and temperature between the two groups (p>0.05). Results of the study showed that prophylactic antibiotics did not have a statistically significant effect on postoperative infections in third molar surgery and should not be routinely administered when third molars are removed in non-immunocompromised patients. CI - Copyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Siddiqi, A AU - Siddiqi A AD - Sir John Walsh Research Institute, School of Dentistry, University of Otago, PO Box 647, Dunedin, New Zealand. siddiqidr@gmail.com FAU - Morkel, J A AU - Morkel JA FAU - Zafar, S AU - Zafar S LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20100201 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Bacterial Agents) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - 804826J2HU (Amoxicillin) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Amoxicillin/therapeutic use MH - Analgesics, Non-Narcotic/therapeutic use MH - Analgesics, Opioid/therapeutic use MH - Anti-Bacterial Agents/therapeutic use MH - *Antibiotic Prophylaxis MH - Codeine/therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Dry Socket/etiology MH - Edema/etiology MH - Female MH - Fever/etiology MH - Follow-Up Studies MH - Humans MH - Ibuprofen/therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/etiology MH - Placebos MH - Prospective Studies MH - Surgical Wound Infection/etiology MH - Tooth Extraction MH - Tooth Socket/pathology MH - Tooth, Impacted/classification/*surgery MH - Trismus/etiology EDAT- 2010/02/02 06:00 MHDA- 2010/05/19 06:00 CRDT- 2010/02/02 06:00 PHST- 2008/04/07 00:00 [received] PHST- 2009/07/23 00:00 [revised] PHST- 2009/12/22 00:00 [accepted] PHST- 2010/02/02 06:00 [entrez] PHST- 2010/02/02 06:00 [pubmed] PHST- 2010/05/19 06:00 [medline] AID - S0901-5027(09)01221-1 [pii] AID - 10.1016/j.ijom.2009.12.014 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2010 Feb;39(2):107-14. doi: 10.1016/j.ijom.2009.12.014. Epub 2010 Feb 1. PMID- 27284581 OWN - NLM STAT- MEDLINE DCOM- 20170905 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 47 IP - 7 DP - 2016 TI - Effect of vasoconstriction on pain after mandibular third molar surgery: A single-blind, randomized controlled trial. PG - 589-96 LID - 10.3290/j.qi.a36174 [doi] AB - OBJECTIVES: Previous research has demonstrated the efficacy of using local compression to reduce postoperative pain after third molar surgery. It has been theorized that compression reduces pain intensity through vasoconstriction. The current research tests the veracity of this vasoconstriction hypothesis by testing the impact of local epinephrine (a local vasoconstrictor) versus a control on patients' pain ratings over 7 days following surgery. METHOD AND MATERIALS: Fifty patients scheduled for mandibular third molar surgery were randomly assigned to receive one cartridge of Ultracaine DS Forte (the treatment group) or one cartridge of Ultracaine DS (the control group) after surgical removal of the third molar. Participants used the visual analog scale (VAS) to provide daily ratings of pain intensity for 7 days following surgery. In addition, on day 7, the perceived effectiveness of the pain treatment was measured with the global perceived effect (GPE) scale. A quality- of-life questionnaire was also completed. RESULTS: A repeated-measures ANOVA indicated that the treatment group perceived significantly less pain than the control group on days 2 to 7 following surgery. In addition, 77.8% of the treatment group perceived their pain treatment to be successful, while only 69.6% of the control group reported that their pain was reduced successfully by day 7. CONCLUSION: The results of this study provide an initial proof of concept that epinephrine may have an analgesic effect on the period following third molar surgery. Further research with larger sample sizes is needed to strengthen evidence for the clinical utility of offering localized epinephrine to patients following third molar surgery. FAU - Martin, Wilhelmus J J M AU - Martin WJ FAU - Skorpil, Nynke E AU - Skorpil NE FAU - Ashton-James, Claire E AU - Ashton-James CE FAU - Tuinzing, D Bram AU - Tuinzing DB FAU - Forouzanfar, Tymour AU - Forouzanfar T LA - eng PT - Journal Article PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - D3SQ406G9X (Carticaine) RN - YKH834O4BH (Epinephrine) SB - D MH - Adolescent MH - Adult MH - Anesthetics, Local/*therapeutic use MH - Carticaine/*therapeutic use MH - Epinephrine/*therapeutic use MH - Female MH - Humans MH - Male MH - Mandible MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Management MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Prospective Studies MH - Quality of Life MH - Single-Blind Method MH - *Tooth Extraction MH - Treatment Outcome MH - Vasoconstrictor Agents/*therapeutic use EDAT- 2016/06/11 06:00 MHDA- 2017/09/07 06:00 CRDT- 2016/06/11 06:00 PHST- 2016/06/11 06:00 [entrez] PHST- 2016/06/11 06:00 [pubmed] PHST- 2017/09/07 06:00 [medline] AID - 840954 [pii] AID - 10.3290/j.qi.a36174 [doi] PST - ppublish SO - Quintessence Int. 2016;47(7):589-96. doi: 10.3290/j.qi.a36174. PMID- 21342008 OWN - NLM STAT- MEDLINE DCOM- 20120207 LR - 20161125 IS - 1943-3670 (Electronic) IS - 0022-3492 (Linking) VI - 82 IP - 10 DP - 2011 Oct TI - Treatment of intrabony defects after impacted mandibular third molar removal with bioabsorbable and non-resorbable membranes. PG - 1404-13 LID - 10.1902/jop.2011.100466 [doi] AB - BACKGROUND: Mandibular second molar (M2) periodontal defects after third molar (M3) removal in high-risk patients are a clinical dilemma for clinicians. This study compares the healing of periodontal intrabony defects at distal surfaces of mandibular M2s using bioabsorbable and non-resorbable membranes. METHODS: Eleven patients with bilateral probing depths (PDs) ≥6 mm distal to mandibular M2s and intrabony defects ≥3 mm, related to the total impaction of M3s, were treated with M3 extraction and covering of the surgical bone defect with a bioabsorbable collagen barrier on one side and a non-resorbable expanded polytetrafluoroethylene (ePTFE) barrier contralaterally. The PD, clinical attachment level (CAL), M2 mobility, and furcation class probing were evaluated preoperatively and 3, 6, and 9 months postoperatively. Intraoral periapical radiographs were taken immediately preoperatively and 3 and 9 months postoperatively. RESULTS: Both treatment modalities were successful. At 9 months, the mean PD reduction was 5.2 ± 3.9 mm for bioabsorbable sites and 5.5 ± 3.0 mm for non-resorbable sites; the CAL gain was 5.9 ± 3.3 mm and 5.5 ± 3.4 mm, respectively. The outcome difference between the two sites for PD and CAL did not differ statistically (P >0.05) at any assessment time. CONCLUSION: Bioabsorbable collagen membranes in guided tissue regeneration treatment of intrabony defects distal to the mandibular M2 obtained the same marked PD reductions and CAL gains as non-resorbable ePTFE membranes after M3 extraction. FAU - Corinaldesi, Giuseppe AU - Corinaldesi G AD - Department of Oral and Dental Sciences, University of Bologna, Bologna, Italy. FAU - Lizio, Giuseppe AU - Lizio G FAU - Badiali, Giovanni AU - Badiali G FAU - Morselli-Labate, Antonio M AU - Morselli-Labate AM FAU - Marchetti, Claudio AU - Marchetti C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110222 PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 RN - 0 (Membranes, Artificial) RN - 9002-84-0 (Polytetrafluoroethylene) SB - D SB - IM MH - Absorbable Implants MH - Adult MH - Alveolar Bone Loss/diagnostic imaging/etiology/*surgery MH - Analysis of Variance MH - Female MH - Guided Tissue Regeneration, Periodontal/*instrumentation MH - Humans MH - Male MH - *Membranes, Artificial MH - Middle Aged MH - Molar, Third/*surgery MH - Periodontal Index MH - Polytetrafluoroethylene MH - Prospective Studies MH - Radiography MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 2011/02/24 06:00 MHDA- 2012/02/09 06:00 CRDT- 2011/02/24 06:00 PHST- 2011/02/24 06:00 [entrez] PHST- 2011/02/24 06:00 [pubmed] PHST- 2012/02/09 06:00 [medline] AID - 10.1902/jop.2011.100466 [doi] PST - ppublish SO - J Periodontol. 2011 Oct;82(10):1404-13. doi: 10.1902/jop.2011.100466. Epub 2011 Feb 22. PMID- 26388067 OWN - NLM STAT- MEDLINE DCOM- 20160929 LR - 20151010 IS - 2212-4411 (Electronic) VI - 120 IP - 5 DP - 2015 Nov TI - High weight standard and removal of third molars: a prospective randomized study. PG - 554-61 LID - S2212-4403(14)01415-1 [pii] LID - 10.1016/j.oooo.2014.12.010 [doi] AB - OBJECTIVE: Compare the degree of exposure to adverse events during the removal of third molars between 2 groups of patients. STUDY DESIGN: Researchers designed and implemented a prospective randomized study. The study consisted of overweight and normal-weight patients subjected to the surgical removal of impacted lower third molars. A wide range of predictor variables was registered in the preoperative phase. Statistical calculations were computed. RESULTS: Five hundred sixty surgeries were performed involving 2 groups (1:1). Adverse events were found in 29.3% of surgeries in overweight patients. The same procedures performed on normal-weight patients resulted in a complication rate of 10.7%. Predictor variables significant to these events were detected. CONCLUSIONS: Overweight patients have 3 times greater risk of experiencing morbidities during the removal of lower third molars compared with patients of normal weight. Our findings have important implications for public health, given the exorbitant growth in the population of patients with high standard weight. CI - Copyright © 2015 Elsevier Inc. All rights reserved. FAU - de Carvalho, Ricardo Wathson Feitosa AU - de Carvalho RW AD - Researcher, PhD Program in Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Pernambuco, Brazil. Electronic address: wathson@ig.com.br. FAU - do Egito Vasconcelos, Belmiro Cavalcanti AU - do Egito Vasconcelos BC AD - Associate Professor and Chairman, PhD Program in Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Pernambuco, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20141224 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 SB - D SB - IM MH - Adult MH - *Body Weight MH - Brazil/epidemiology MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Postoperative Complications/*epidemiology MH - Risk Factors MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2015/09/22 06:00 MHDA- 2016/09/30 06:00 CRDT- 2015/09/22 06:00 PHST- 2014/08/23 00:00 [received] PHST- 2014/10/27 00:00 [revised] PHST- 2014/12/12 00:00 [accepted] PHST- 2015/09/22 06:00 [entrez] PHST- 2015/09/22 06:00 [pubmed] PHST- 2016/09/30 06:00 [medline] AID - S2212-4403(14)01415-1 [pii] AID - 10.1016/j.oooo.2014.12.010 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Nov;120(5):554-61. doi: 10.1016/j.oooo.2014.12.010. Epub 2014 Dec 24. PMID- 23497981 OWN - NLM STAT- MEDLINE DCOM- 20140211 LR - 20140507 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 42 IP - 7 DP - 2013 Jul TI - Intranasal atomized dexmedetomidine for sedation during third molar extraction. PG - 857-62 LID - S0901-5027(13)00066-0 [pii] LID - 10.1016/j.ijom.2013.02.003 [doi] AB - The purpose of this study was to evaluate the intranasal use of 1.5 μg/kg atomized dexmedetomidine for sedation in patients undergoing mandibular third molar removal. Eighteen patients underwent third molar removal in two surgical sessions. Patients were randomly assigned to receive intranasal water (placebo group) or 1.5 μg/kg atomized dexmedetomidine (group D) at the first session. The alternate regimen was used during the second session. Local anaesthesia was injected 30 min after placebo/sedative administration. Pain from local anaesthesia infiltration was rated on a scale from zero (no pain) to 10 (worst pain imaginable). Sedation status was measured every 10 min by a blinded observer with a modified Observer's Assessment of Alertness/Sedation (OAA/S) scale and the bispectral index (BIS). Adverse reactions and analgesic consumption were recorded. Sedation values in group D were significantly different from placebo at 20-30 min, peaked at 40-50 min, and returned to placebo levels at 70-80 min after intranasal drug administration. Group D displayed decreased heart rate and systolic blood pressure, but the decreases did not exceed 20% of the baseline values. Intranasal administration of 1.5 μg/kg atomized dexmedetomidine is effective, convenient, and safe as a sedative for patients undergoing third molar extraction. CI - Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Nooh, N AU - Nooh N AD - Department of Oral and Maxillofacial Surgery, King Saudi University, Riyadh, Saudi Arabia. nassernoohomfs@gmail.com FAU - Sheta, S A AU - Sheta SA FAU - Abdullah, W A AU - Abdullah WA FAU - Abdelhalim, A A AU - Abdelhalim AA LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20130314 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anesthetics, Intravenous) RN - 0 (Hypnotics and Sedatives) RN - 67VB76HONO (Dexmedetomidine) SB - D SB - IM CIN - Int J Oral Maxillofac Surg. 2014 Jan;43(1):131-2. PMID: 24239139 MH - Administration, Intranasal/*methods MH - Adult MH - Anesthesia, Dental/*methods MH - Anesthesia, Local/methods MH - Anesthetics, Intravenous/administration & dosage MH - Dexmedetomidine/*administration & dosage/adverse effects MH - Female MH - Humans MH - Hypnotics and Sedatives/*administration & dosage/adverse effects MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2013/03/19 06:00 MHDA- 2014/02/12 06:00 CRDT- 2013/03/19 06:00 PHST- 2012/06/05 00:00 [received] PHST- 2013/01/01 00:00 [revised] PHST- 2013/02/08 00:00 [accepted] PHST- 2013/03/19 06:00 [entrez] PHST- 2013/03/19 06:00 [pubmed] PHST- 2014/02/12 06:00 [medline] AID - S0901-5027(13)00066-0 [pii] AID - 10.1016/j.ijom.2013.02.003 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2013 Jul;42(7):857-62. doi: 10.1016/j.ijom.2013.02.003. Epub 2013 Mar 14. PMID- 27741414 OWN - NLM STAT- MEDLINE DCOM- 20170418 LR - 20170817 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 75 IP - 1 DP - 2017 Jan TI - Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial. PG - 51.e1-51.e9 LID - S0278-2391(16)30821-7 [pii] LID - 10.1016/j.joms.2016.09.014 [doi] AB - PURPOSE: To assess the influence of topical ozone administration on patient comfort after third molar surgery. MATERIALS AND METHODS: A single-blinded randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the postoperative medication used after third molar surgery. Using the split-mouth design, the study group received topical ozone without postoperative systemic antibiotics, whereas the control group did not receive ozone but only systemic antibiotics. The 2 groups were prescribed analgesics for 2 days. The assessing surgeon was blinded to treatment assignment. The primary outcome variables were postoperative mouth opening, pain, and swelling. The secondary outcome variable was the number of analgesic doses required by each group on postoperative days 3 to 5. Data analysis involved descriptive statistics, paired t tests, and 2-way analysis of variance with repeated measures (P < .05). SPSS 20.0 was used for data analysis. RESULTS: The study sample included 33 patients (n = 33 in each group). The study group showed statistically relevant decreases in postoperative pain, swelling, and trismus. Further, the number of analgesics required was smaller than in the control group. No adverse effects of ozone gel were observed in any patient. CONCLUSION: Ozone gel was found to be an effective topical agent that considerably improves patient comfort postoperatively and can be considered a substitute of postoperative systemic antibiotics. CI - Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Sivalingam, Varun P AU - Sivalingam VP AD - Postgraduate Trainee, Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. FAU - Panneerselvam, Elavenil AU - Panneerselvam E AD - Reader, Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. Electronic address: elavenilomfs@gmail.com. FAU - Raja, Krishnakumar V B AU - Raja KV AD - Professor and Head, Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. FAU - Gopi, Gayathri AU - Gopi G AD - Senior Lecturer, Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Ramapuram, Chennai, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160916 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Gels) RN - 66H7ZZK23N (Ozone) SB - AIM SB - D SB - IM MH - Administration, Topical MH - Adult MH - Anesthesia, Dental/*methods MH - Female MH - Gels MH - Humans MH - Male MH - Molar, Third/*surgery MH - Ozone/administration & dosage/*therapeutic use MH - Pain, Postoperative/*prevention & control MH - Single-Blind Method MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2016/10/26 06:00 MHDA- 2017/04/19 06:00 CRDT- 2016/10/15 06:00 PHST- 2015/10/12 00:00 [received] PHST- 2016/09/08 00:00 [revised] PHST- 2016/09/08 00:00 [accepted] PHST- 2016/10/26 06:00 [pubmed] PHST- 2017/04/19 06:00 [medline] PHST- 2016/10/15 06:00 [entrez] AID - S0278-2391(16)30821-7 [pii] AID - 10.1016/j.joms.2016.09.014 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2017 Jan;75(1):51.e1-51.e9. doi: 10.1016/j.joms.2016.09.014. Epub 2016 Sep 16. PMID- 26597577 OWN - NLM STAT- MEDLINE DCOM- 20161010 LR - 20161230 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 45 IP - 1 DP - 2016 Jan TI - Effectiveness of cold therapy in reducing pain, trismus, and oedema after impacted mandibular third molar surgery: a randomized, self-controlled, observer-blind, split-mouth clinical trial. PG - 118-23 LID - S0901-5027(15)01391-0 [pii] LID - 10.1016/j.ijom.2015.10.021 [doi] AB - Cold therapy is a conventional and widely used modality for reducing pain, trismus, and oedema after dentoalveolar surgeries. However, information reported in the literature on its effectiveness is insufficient and controversial. This study was performed to evaluate the effect of local cold application in reducing pain, trismus, and swelling after impacted mandibular third molar surgery. Thirty patients (seven males and 23 females) with bilateral symmetrical mandibular impacted third molars were enrolled in this randomized, self-controlled, observer-blind clinical trial. The patients were aged between 18 and 30 years. After surgical removal of the tooth on one side (intervention), ice pack therapy was given for 24h after surgery; for the other side (control), no cold therapy was given. The time interval between the two surgeries was at least 4 weeks. The amount of pain, trismus, and facial swelling was measured on days 2 and 7 postoperative, and patient satisfaction with the cold therapy vs. no cold therapy was assessed. The amount of pain, trismus, and facial swelling, and the extent of patient satisfaction were not significantly different between the intervention and control sides. Cold therapy had no beneficial effects on postoperative sequelae after impacted mandibular third molar surgery. CI - Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Zandi, M AU - Zandi M AD - Department of Oral and Maxillofacial Surgery, Hamedan University of Medical Sciences, Hamedan, Iran. Electronic address: zandi88m@yahoo.com. FAU - Amini, P AU - Amini P AD - Department of Biostatistics, Hamedan University of Medical Sciences, Hamedan, Iran. FAU - Keshavarz, A AU - Keshavarz A AD - Faculty of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran. LA - eng SI - IRCT/201410214303N3 PT - Journal Article PT - Randomized Controlled Trial DEP - 20151117 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Cryotherapy/*methods MH - Edema/etiology/*therapy MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology/*therapy MH - Patient Satisfaction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/etiology/*therapy OTO - NOTNLM OT - cold therapy OT - impacted tooth OT - oedema OT - pain OT - trismus EDAT- 2015/11/26 06:00 MHDA- 2016/10/11 06:00 CRDT- 2015/11/25 06:00 PHST- 2015/05/26 00:00 [received] PHST- 2015/08/13 00:00 [revised] PHST- 2015/10/23 00:00 [accepted] PHST- 2015/11/25 06:00 [entrez] PHST- 2015/11/26 06:00 [pubmed] PHST- 2016/10/11 06:00 [medline] AID - S0901-5027(15)01391-0 [pii] AID - 10.1016/j.ijom.2015.10.021 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2016 Jan;45(1):118-23. doi: 10.1016/j.ijom.2015.10.021. Epub 2015 Nov 17. PMID- 28874646 OWN - NLM STAT- MEDLINE DCOM- 20180727 LR - 20191027 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 18 IP - 9 DP - 2017 Sep 1 TI - Comparative Evaluation of Two Different Flap Designs and Postoperative Outcome in the Surgical Removal of Impacted Mandibular Third Molar. PG - 807-811 AB - AIM: The aim of this study is to compare triangular and envelope flap designs and the postoperative outcome in the surgical removal of impacted mandibular third molar. MATERIALS AND METHODS: A total of 50 participants were assessed clinically and were divided randomly into two groups. Group I (participants operated by triangular flap) and group II (participants operated by envelope flap), with 25 participants each between the age group of 20 and 30 years. Patient satisfaction was assessed subjectively using a graded scale from very satisfied to very unsatisfied. The degree of pain was recorded for 7 days with reference to predefined values on visual analog scale (VAS). Trismus was evaluated on the day 3, day 5, and day 7 of the postoperative period in millimeters. Quantitative data were analyzed by unpaired t-test and qualitative data were by Fischer's exact test. RESULTS: The mean overall age is 25.5 years. There was no statistically significant difference between the study groups with respect to age. There was no significant association between the patient satisfaction and flap type (p = 0.684). A significant difference between the study groups on 4th, 5th, and 6th days with respect to pain was observed, wherein fewer subjects operated with triangular flap reported pain. A highly significant difference in mouth opening was observed, with triangular flap group participants having a higher mouth opening than envelope flap subjects on day 7. CONCLUSION: The present study indicated that participants operated by triangular flap had a better mouth opening postoperatively compared with envelope flap participants, whereas there were no significant differences in patient satisfaction and pain scores at the end of the 7th day after third molar surgery. CLINICAL SIGNIFICANCE: Flap design is a significant factor in the surgical removal of impacted third molar, and it influences the severity of complications. Furthermore, it is important for allowing optimal visibility and access to the impacted tooth and also for subsequent healing of the surgically created defect. FAU - Rabi, A AU - Rabi A AD - Department of Oral and Maxillofacial Surgery, Government Medical College, Kollam, Kerala, India, e-mail: drrabi@hotmail.com. FAU - Haris, P M Mohamed AU - Haris PMM AD - Department of Periodontics, Malabar Dental College & Research Centre, Edappal, Kerala, India. FAU - Panickal, Deepu M AU - Panickal DM AD - Department of Periodontics, Malabar Dental College & Research Centre, Edappal, Kerala, India. FAU - Ahamed, Shabeer AU - Ahamed S AD - Department of Periodontics, Malabar Dental College & Research Centre, Edappal, Kerala, India. FAU - Pulikkottil, Venith J AU - Pulikkottil VJ AD - Department of Orthodontics and Dentofacial Orthopedics Malabar Dental College & Research Centre, Edappal, Kerala India. FAU - Haris, K T Muhamed AU - Haris KTM AD - Department of Oral and Maxillofacial Pathology, Malabar Dental College & Research Centre, Edappal, Kerala, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20170901 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 SB - D SB - IM MH - Adult MH - Humans MH - Molar, Third/*surgery MH - *Surgical Flaps MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - Flap design OT - Impacted OT - Incision OT - Mandibular third molar Postoperative outcome. EDAT- 2017/09/07 06:00 MHDA- 2018/07/28 06:00 CRDT- 2017/09/07 06:00 PHST- 2017/09/07 06:00 [entrez] PHST- 2017/09/07 06:00 [pubmed] PHST- 2018/07/28 06:00 [medline] AID - 1526-3711-1899 [pii] AID - 10.5005/jp-journals-10024-2131 [doi] PST - epublish SO - J Contemp Dent Pract. 2017 Sep 1;18(9):807-811. doi: 10.5005/jp-journals-10024-2131. PMID- 28597117 OWN - NLM STAT- MEDLINE DCOM- 20190226 LR - 20190226 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 21 IP - 3 DP - 2017 Sep TI - Oral dexamethasone decreases postoperative pain, swelling, and trismus more than diclofenac following third molar removal: a randomized controlled clinical trial. PG - 321-326 LID - 10.1007/s10006-017-0635-0 [doi] AB - PURPOSE: The aim of this study was to compare the anti-inflammatory potential of two pharmacotherapy protocols based on the parameters of pain, trismus, and swelling, after extraction of third molars. METHODS: Thirty patients selected with symmetrical impaction of third molars were submitted to surgical procedures in both sides in different times. For one group, dexamethasone was used for 3 days, and for another group diclofenac sodium was also used for the same period. The main variables analyzed were the visual analogue pain scale (VAS), but others were also analyzed such as swelling and trismus, which were submitted to statistical analysis. RESULTS: The results had no difference regarding the length of procedures (p = 0.986) and the pain in the immediate and 4-h postoperative period (p = 0.723 and 0.541). The rescue analgesic consumption was higher (p < 0.05) when using the protocol with diclofenac sodium. The variables mouth opening (p < 0.05) and swelling (p < 0.05) were significantly better when using the protocol with dexamethasone in the postoperative period. CONCLUSIONS: Medical protocol with the use of dexamethasone in the postoperative period was more effective in controlling pain, trismus, and swelling, after the extraction of third molars, when compared to diclofenac sodium. FAU - Lima, Carlos Alysson Aragão AU - Lima CAA AD - Resident of Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, São Paulo, Brazil. FAU - Favarini, Vinícius Tatsumoto AU - Favarini VT AD - Resident of Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, São Paulo, Brazil. FAU - Torres, Alexandre Machado AU - Torres AM AD - Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, São Paulo, Brazil. FAU - da Silva, Rogério Almeida AU - da Silva RA AD - Oral and Maxillofacial Surgery Department, Hospital Geral de Vila Penteado, São Paulo, Brazil. FAU - Sato, Fábio Ricardo Loureiro AU - Sato FRL AD - Oral and Maxillofacial Surgery Area, State University of São Paulo-UNESP, College of Dentistry, São José dos Campos and Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, Av. Eng. Francisco José Longo, 777-12245-000, São José dos Campos, São Paulo, SP, Brazil. fabio.sato@ict.unesp.br. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20170608 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Anti-Inflammatory Agents) RN - 144O8QL0L1 (Diclofenac) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM CIN - J Am Dent Assoc. 2017 Oct;148(10):e154. PMID: 28821342 MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/therapeutic use MH - Dexamethasone/*therapeutic use MH - Diclofenac/therapeutic use MH - Double-Blind Method MH - Edema/*drug therapy MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus/*drug therapy MH - Young Adult OTO - NOTNLM OT - Corticosteroids OT - Pain OT - Swelling OT - Third molar surgery OT - Trismus EDAT- 2017/06/10 06:00 MHDA- 2019/02/27 06:00 CRDT- 2017/06/10 06:00 PHST- 2016/08/28 00:00 [received] PHST- 2017/05/29 00:00 [accepted] PHST- 2017/06/10 06:00 [pubmed] PHST- 2019/02/27 06:00 [medline] PHST- 2017/06/10 06:00 [entrez] AID - 10.1007/s10006-017-0635-0 [pii] AID - 10.1007/s10006-017-0635-0 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2017 Sep;21(3):321-326. doi: 10.1007/s10006-017-0635-0. Epub 2017 Jun 8. PMID- 26648386 OWN - NLM STAT- MEDLINE DCOM- 20160421 LR - 20181113 IS - 0250-832X (Print) IS - 1476-542X (Electronic) IS - 0250-832X (Linking) VI - 45 IP - 2 DP - 2016 TI - Neurosensoric disturbances after surgical removal of the mandibular third molar based on either panoramic imaging or cone beam CT scanning: A randomized controlled trial (RCT). PG - 20150224 LID - 10.1259/dmfr.20150224 [doi] LID - 20150224 AB - OBJECTIVE: Pre-surgical CBCT has been suggested before removal of the mandibular third molar. Currently, the standard-of-care is two-dimensional (2D) panoramic imaging. The aim of this randomized controlled trial was to analyse possible differences in neurosensoric disturbances of the inferior alveolar nerve between patients undergoing either panoramic imaging or CBCT before surgical removal of the mandibular third molar. Furthermore, the aim was to perform a sensitivity analysis to assess the statistical significance of different assumptions related to sample size calculations. METHODS: 230 patients were randomized to a scan group and a non-scan group. All patients were referred from practicing dentists in the Copenhagen area. Inclusion criteria were overlap of the root complex and the mandibular canal on a 2D radiographic image. Central allocation of the randomization code and double blind settings were established. The surgical removal was performed in a specialized surgical practice geographically and personally separated from the study practice. Registration of neurosensoric anomalies was performed with a Semmes-Weinstein test and a visual analogue scale questionnaire pre- and post-surgically. RESULTS: In the scan group (n = 114), 21 episodes of neurosensoric disturbances were registered and in the non-scan group (n = 116), 13 episodes of neurosensoric disturbances were registered. There was no statistically significant difference between the two groups (p = 0.14). Performing a sensitivity analysis confirmed that CBCT was not superior to panoramic imaging in avoiding neurosensoric disturbances. CONCLUSIONS: The use of CBCT before removal of the mandibular third molar does not seem to reduce the number of neurosensoric disturbances. FAU - Petersen, Lars B AU - Petersen LB AD - 1 Section for Oral Radiology, Department of Dentistry, Aarhus University, Aarhus, Denmark. FAU - Vaeth, Michael AU - Vaeth M AD - 2 Department of Public Health, Department of Biostatistics, Aarhus University, Aarhus, Denmark. FAU - Wenzel, Ann AU - Wenzel A AD - 1 Section for Oral Radiology, Department of Dentistry, Aarhus University, Aarhus, Denmark. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20151209 TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - D MH - Adult MH - Cone-Beam Computed Tomography/*methods/statistics & numerical data MH - Cranial Nerve Diseases/*etiology MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mandibular Nerve/*physiopathology MH - Molar, Third/diagnostic imaging/*surgery MH - Radiography, Panoramic/*methods/statistics & numerical data MH - Sensitivity and Specificity MH - Somatosensory Disorders/*etiology MH - Tooth Crown/surgery MH - Tooth Extraction/methods MH - Visual Analog Scale MH - Young Adult PMC - PMC5308576 OTO - NOTNLM OT - CBCT scanning OT - mandibular third molar OT - neurosensoric disturbances OT - surgical removal EDAT- 2015/12/10 06:00 MHDA- 2016/04/22 06:00 CRDT- 2015/12/10 06:00 PHST- 2015/12/10 06:00 [entrez] PHST- 2015/12/10 06:00 [pubmed] PHST- 2016/04/22 06:00 [medline] AID - 10.1259/dmfr.20150224 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 2016;45(2):20150224. doi: 10.1259/dmfr.20150224. Epub 2015 Dec 9. PMID- 30145192 OWN - NLM STAT- MEDLINE DCOM- 20191008 LR - 20191008 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 76 IP - 12 DP - 2018 Dec TI - Periodontal Regenerative Therapy for Preventing Bone Defects Distal to Mandibular Second Molars After Surgical Removal of Impacted Third Molars: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. PG - 2482-2514 LID - S0278-2391(18)30846-2 [pii] LID - 10.1016/j.joms.2018.07.025 [doi] AB - PURPOSE: The purpose of this study was to assess which regenerative techniques are most effective for preventing periodontal defects after extraction of the third molars, as well as to compare these procedures with spontaneous healing of the socket. MATERIALS AND METHODS: Five electronic databases were searched to identify randomized clinical trials that fulfilled the eligibility criteria. Two independent reviewers conducted literature screening, article selection, and data extraction. The outcome measures were mean clinical attachment level (CAL) gain, mean probing depth (PD) reduction, mean alveolar bone level (ABL) gain, and adverse events. The influence of several variables of interest on the outcomes of periodontal regenerative therapy was explored via subgroup analyses. RESULTS: Among 1,205 potentially eligible articles, 21 randomized clinical trials were included. Eighteen trials assessed periodontal regenerative therapy as an alternative to extraction alone. Statistically significant differences were found in CAL gain (1.98 mm; 95% confidence interval [CI], 1.44 to 2.52 mm; P < .001), PD reduction (1.76 mm; 95% CI, 1.20 to 2.31 mm; P < .001), and ABL gain (1.21 mm; 95% CI, 0.21 to 2.21 mm; P = .018). The risk of complications developing at treated sites did not increase with the regenerative procedures (odds ratio, 1.49; 95% CI, 0.71 to 3.14; P = .290). There was no evidence of any regenerative procedure being better than any other. However, osseous grafting techniques were associated with a significantly higher adverse event rate. CONCLUSIONS: Regenerative periodontal therapy, in comparison with spontaneous healing of the wound, is more effective regarding initial improvement in CAL gain, PD reduction, and ABL gain, without increasing the risk of postoperative complications. CI - Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Camps-Font, Octavi AU - Camps-Font O AD - Master of Oral Surgery and Implantology, Associate Professor of Oral Surgery, and Professor of Master's Degree Program in Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. Electronic address: ocamps@ub.edu. FAU - Caro-Bonfill, Cristina AU - Caro-Bonfill C AD - Dentist, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. FAU - Sánchez-Garcés, Maria Àngels AU - Sánchez-Garcés MÀ AD - Master of Oral Surgery and Implantology, Associate Professor of Oral Surgery, and Professor of Master's Degree Program in Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; and Researcher, Bellvitge Biomedical Research Institute, Barcelona, Spain. FAU - Gay-Escoda, Cosme AU - Gay-Escoda C AD - Chairman and Professor of Oral and Maxillofacial Surgery, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Director of Master's Degree Program in Oral Surgery and Implantology, European Foundation for Health Research and Education International University, Belize City, Belize and Private Catalan Foundation for Oral Health, Barcelona, Spain; Coordinator/Researcher, Bellvitge Biomedical Research Institute, Barcelona, Spain; and Head of Oral Surgery, Implantology and Maxillofacial Surgery Department, Teknon Medical Center, Barcelona, Spain. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20180730 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Guided Tissue Regeneration, Periodontal/*methods MH - Humans MH - Molar, Third/*surgery MH - Periodontal Diseases/etiology/*prevention & control MH - Postoperative Complications/*prevention & control MH - Randomized Controlled Trials as Topic MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2018/08/27 06:00 MHDA- 2019/10/09 06:00 CRDT- 2018/08/27 06:00 PHST- 2018/02/21 00:00 [received] PHST- 2018/07/22 00:00 [revised] PHST- 2018/07/22 00:00 [accepted] PHST- 2018/08/27 06:00 [pubmed] PHST- 2019/10/09 06:00 [medline] PHST- 2018/08/27 06:00 [entrez] AID - S0278-2391(18)30846-2 [pii] AID - 10.1016/j.joms.2018.07.025 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2018 Dec;76(12):2482-2514. doi: 10.1016/j.joms.2018.07.025. Epub 2018 Jul 30. PMID- 19464207 OWN - NLM STAT- MEDLINE DCOM- 20090929 LR - 20090622 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 108 IP - 1 DP - 2009 Jul TI - Tissue adhesive and suturing for closure of the surgical wound after removal of impacted mandibular third molars: a comparative study. PG - e14-6 LID - 10.1016/j.tripleo.2009.03.001 [doi] AB - OBJECTIVE: The most common method of wound closure in oral surgery is suturing. The efficacy of cyanoacrylate in postoperative pain and bleeding was evaluated and compared with suturing. MATERIALS AND METHODS: Sixteen patients with similar bone impaction and inclination of mandibular third molars on the right and left sides were studied in this controlled clinical trial. The third molar surgery was carried out in 2 stages, 4 weeks apart, under local anesthesia. After bone removal and tooth resection, the right flap was closed with 3-0 silk sutures and the left flap with cyanoacrylate. A visual analogical scale was used to evaluate the severity of pain and bleeding on postoperative days. RESULTS: The data analysis showed that postoperative bleeding with cyanoacrylate method was less significant than with suturing on the first and second days after surgery (P < .05). There was no significant difference in the severity of pain between the 2 methods (P > .05). CONCLUSION: This study suggested that the efficacies of cyanoacrylate and suturing in wound closure were similar in the severity of pain, but use of cyanoacrylate resulted in better hemostasis. FAU - Ghoreishian, Mehdi AU - Ghoreishian M AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Gheisari, Rasoul AU - Gheisari R FAU - Fayazi, Maasoumeh AU - Fayazi M LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article DEP - 20090522 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Cyanoacrylates) RN - 0 (Silk) RN - 0 (Tissue Adhesives) SB - D SB - IM MH - Adolescent MH - Cyanoacrylates/therapeutic use MH - Female MH - Follow-Up Studies MH - Hemostatic Techniques MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Osteotomy/methods MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Postoperative Hemorrhage/prevention & control MH - Silk MH - Surgical Flaps MH - *Sutures MH - Tissue Adhesives/*therapeutic use MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2009/05/26 09:00 MHDA- 2009/09/30 06:00 CRDT- 2009/05/26 09:00 PHST- 2008/11/27 00:00 [received] PHST- 2009/01/26 00:00 [revised] PHST- 2009/03/03 00:00 [accepted] PHST- 2009/05/26 09:00 [entrez] PHST- 2009/05/26 09:00 [pubmed] PHST- 2009/09/30 06:00 [medline] AID - S1079-2104(09)00153-X [pii] AID - 10.1016/j.tripleo.2009.03.001 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jul;108(1):e14-6. doi: 10.1016/j.tripleo.2009.03.001. Epub 2009 May 22. PMID- 17665051 OWN - NLM STAT- MEDLINE DCOM- 20080424 LR - 20190606 IS - 0100-879X (Print) IS - 0100-879X (Linking) VI - 40 IP - 8 DP - 2007 Aug TI - The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal. PG - 1133-40 AB - We compared the clinical efficacy of orally administered valdecoxib and piroxicam for the prevention of pain, trismus and swelling after removal of horizontally and totally intrabony impacted lower third molars. Twenty-five patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Valdecoxib (40 mg) or piroxicam (20 mg) was administered in a double-blind, randomized and crossed manner for 4 days after the surgical procedures. Objective and subjective parameters were recorded for comparison of postoperative courses. Both agents were effective for postoperative pain relief (N = 19). There was a similar mouth opening at suture removal compared with the preoperative values (86.14 +/- 4.36 and 93.12 +/- 3.70% of the initial measure for valdecoxib and piroxicam, respectively; ANOVA). There was no significant difference regarding the total amount of rescue medication taken by the patients treated with valdecoxib or piroxicam (173.08 +/- 91.21 and 461.54 +/- 199.85 mg, respectively; Wilcoxon test). There were no significant differences concerning the swelling observed on the second postoperative day compared to baseline measures (6.15 +/- 1.84 and 8.46 +/- 2.04 mm for valdecoxib and piroxicam, respectively; ANOVA) or on the seventh postoperative day (1.69 +/- 1.61 and 2.23 +/- 2.09 mm for valdecoxib and piroxicam, respectively; ANOVA). The cyclooxygenase-2 selective inhibitor valdecoxib is as effective as the non-selective cyclooxygenase inhibitor piroxicam for pain, trismus and swelling control after removal of horizontally and totally intrabony impacted lower third molars. FAU - Benetello, V AU - Benetello V AD - Departamento de Ciências Biológicas, Faculdade de Odontologia de Bauru, Universidade de São Paulo, 17012-901 Bauru, SP, Brazil. FAU - Sakamoto, F C AU - Sakamoto FC FAU - Giglio, F P M AU - Giglio FP FAU - Sakai, V T AU - Sakai VT FAU - Calvo, A M AU - Calvo AM FAU - Modena, K C S AU - Modena KC FAU - Colombini, B L AU - Colombini BL FAU - Dionísio, T J AU - Dionísio TJ FAU - Lauris, J R P AU - Lauris JR FAU - Faria, F A C AU - Faria FA FAU - Santos, C F AU - Santos CF LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Brazil TA - Braz J Med Biol Res JT - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas JID - 8112917 RN - 0 (Cyclooxygenase Inhibitors) RN - 0 (Isoxazoles) RN - 0 (Sulfonamides) RN - 13T4O6VMAM (Piroxicam) RN - 2919279Q3W (valdecoxib) SB - IM MH - Adult MH - Cyclooxygenase Inhibitors/*therapeutic use MH - Double-Blind Method MH - Edema/*drug therapy MH - Female MH - Humans MH - Isoxazoles/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*therapeutic use MH - Sulfonamides/*therapeutic use MH - Tooth Extraction MH - Treatment Outcome MH - Trismus/*drug therapy EDAT- 2007/08/01 09:00 MHDA- 2008/04/25 09:00 CRDT- 2007/08/01 09:00 PHST- 2006/10/20 00:00 [received] PHST- 2007/04/23 00:00 [accepted] PHST- 2007/08/01 09:00 [pubmed] PHST- 2008/04/25 09:00 [medline] PHST- 2007/08/01 09:00 [entrez] AID - S0100-879X2007000800015 [pii] AID - 10.1590/s0100-879x2006005000123 [doi] PST - ppublish SO - Braz J Med Biol Res. 2007 Aug;40(8):1133-40. doi: 10.1590/s0100-879x2006005000123. PMID- 2648144 OWN - NLM STAT- MEDLINE DCOM- 19890428 LR - 20131121 IS - 0028-4793 (Print) IS - 0028-4793 (Linking) VI - 320 IP - 13 DP - 1989 Mar 30 TI - Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery. PG - 840-3 AB - We carried out a placebo-controlled, double-blind, randomized study of the hemostatic effect of tranexamic acid mouthwash after oral surgery in 39 patients receiving anticoagulant agents because of the presence of cardiac valvular stenosis, a prosthetic cardiac valve, or a vascular prosthesis. Surgery was performed with no change in the level of anticoagulant therapy, and treatment with the anticoagulant agent was continued after surgery. Before it was sutured, the operative field was irrigated in 19 patients with 10 ml of a 4.8 percent aqueous solution of tranexamic acid (an inhibitor of fibrinolysis) and in 20 patients with a placebo solution. For seven days thereafter, patients were instructed to rinse their mouths with 10 ml of the assigned solution for two minutes four times a day. There were no significant differences between the two treatment groups in base-line variables, including the level of anticoagulation at the time of surgery. Eight patients in the placebo group had a total of 10 postoperative bleeding episodes, whereas only 1 patient in the tranexamic acid group had a bleeding episode (P = 0.01). There were no systemic side effects. We conclude that local antifibrinolytic therapy is effective in preventing bleeding after oral surgery in patients who are being treated with anticoagulants. FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S AD - Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Denmark. FAU - Ramström, G AU - Ramström G FAU - Bernvil, S AU - Bernvil S FAU - Blombäck, M AU - Blombäck M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - N Engl J Med JT - The New England journal of medicine JID - 0255562 RN - 0 (Anticoagulants) RN - 0 (Cyclohexanecarboxylic Acids) RN - 0 (Mouthwashes) RN - 6T84R30KC1 (Tranexamic Acid) SB - AIM SB - IM MH - Adult MH - Aged MH - Anticoagulants/*adverse effects MH - Clinical Trials as Topic MH - Cyclohexanecarboxylic Acids/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Mouthwashes MH - Random Allocation MH - *Surgery, Oral MH - Tooth Extraction MH - Tranexamic Acid/*administration & dosage/therapeutic use EDAT- 1989/03/30 00:00 MHDA- 1989/03/30 00:01 CRDT- 1989/03/30 00:00 PHST- 1989/03/30 00:00 [pubmed] PHST- 1989/03/30 00:01 [medline] PHST- 1989/03/30 00:00 [entrez] AID - 10.1056/NEJM198903303201305 [doi] PST - ppublish SO - N Engl J Med. 1989 Mar 30;320(13):840-3. doi: 10.1056/NEJM198903303201305. PMID- 29568027 OWN - NLM STAT- MEDLINE DCOM- 20180605 LR - 20181202 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 19 IP - 1 DP - 2018 Mar 23 TI - Chlorhexidine gel to prevent alveolar osteitis following mandibular third molar extractions. PG - 16-17 LID - 10.1038/sj.ebd.6401288 [doi] AB - Data sourcesMedline/PubMed, Cochrane central, Scopus and Google scholar.Study selectionRandomised controlled trials (RCTs) published in English between January 2010 and December 2015 were identified by two reviewers. Unpublished studies were not considered.Data extraction and synthesisStandard Cochrane Collaboration assessment tools were used to carry out a risk of bias assessment. The following data were collected from the articles; sample size, country, mean age of participants, diagnosis of alveolar osteitis (AO), type of intervention and outcomes. Heterogeneity (I(2)) was calculated to determine the statistical model to be used for meta-analysis.ResultsTen randomised control trials (RCTs) were included, with 862 participants. Eight studies used 0.2% chlorhexidine (CHX) gel in the experimental group, 1% CHX gel in one study, and in one study the concentration was not specified. Two studies used adjunctive antibiotics, and one study gave 400mg Ibuprofen to all participants.Six of the RCTs were at low risk of bias, three studies showed possible selection and/or performance bias, and one study gave no information on bias. Heterogeneity was low level (I(2) = 40%) and a funnel plot presented a low level of publication bias.The included RCTs used Blum's criteria for diagnosis of AO. Six of the RCTs were conducted double-blinded. The risk ratio (RR) was calculated for each RCT and also for the pooled effect. The overall pooled effect of CHX gel placed in the extraction socket following mandibular 3rd molar removal was calculated to have prevented 57% of AO instances (RR = 0.43, 95% CI: 0.32, 0.58; p<0.00001). Subgroup analysis of the effect of CHX gel in participants who smoked/used the oral contraceptive pill (OCP) was calculated to have prevented 40% of AO (RR = 0.60, 95% CI: 0.41, 0.87; p = 0.007). In the studies that used a split-mouth design, CHX gel prevented 71% of AO incidence (RR = 0.29, 95% CI: 0.16, 0.50; p <0.0001).ConclusionsThis meta-analysis and systematic review concluded 'clinically significant evidence that CHX gel application in the extraction socket of mandibular 3rd molar has reduced the incidence of alveolar osteitis'. FAU - Dobson, Marianne AU - Dobson M AD - Dental Core Trainees, Dundee Dental Hospital and School, Dundee, Scotland, UK. FAU - Pillon, Louisa AU - Pillon L AD - Dental Core Trainees, Dundee Dental Hospital and School, Dundee, Scotland, UK. FAU - Kwon, Ohsun AU - Kwon O AD - Dental Core Trainees, Dundee Dental Hospital and School, Dundee, Scotland, UK. FAU - Innes, Nicola AU - Innes N AD - Professor of Paediatric Dentistry/Associate Dean for Learning & Teaching, Dundee Dental School, University of Dundee, Dundee, Scotland, UK. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM CON - BMC Oral Health. 2017 May 19;17 (1):82. PMID: 28526078 EIN - Evid Based Dent. 2018 Dec;19(4):101. PMID: 30573853 MH - *Chlorhexidine MH - *Dry Socket MH - Mandible MH - Molar MH - Molar, Third EDAT- 2018/03/24 06:00 MHDA- 2018/06/06 06:00 CRDT- 2018/03/24 06:00 PHST- 2018/03/24 06:00 [entrez] PHST- 2018/03/24 06:00 [pubmed] PHST- 2018/06/06 06:00 [medline] AID - 6401288 [pii] AID - 10.1038/sj.ebd.6401288 [doi] PST - ppublish SO - Evid Based Dent. 2018 Mar 23;19(1):16-17. doi: 10.1038/sj.ebd.6401288. PMID- 32691298 OWN - NLM STAT- MEDLINE DCOM- 20210107 LR - 20210111 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 25 IP - 1 DP - 2021 Jan TI - Effect of drain application on postoperative complaints after surgical removal of impacted wisdom teeth-a randomized observer-blinded split-mouth clinical trial. PG - 345-353 LID - 10.1007/s00784-020-03464-5 [doi] AB - OBJECTIVES: The aim of this randomized observer-blinded split-mouth-study is to objectively assess the influence of a rubber drain on postoperative swelling using 3D face scans as measurement method and additionally evaluate pain, trismus and complications after the osteotomy of lower third molars. MATERIAL AND METHODS: Seventy-two patients with symmetrically impacted lower wisdom teeth were recruited. Before the operation, patients rated pain using the visual analogue scale, the interincisal distance was measured, and 3D face scans were taken with an optical scanner. Each patient underwent two procedures which were at least 30 days apart. On one side, a rubber drain was inserted randomly before closure, the contralateral control side was closed without drainage. On the third and tenth postoperative day, face scans to quantify the swelling, pain evaluation and trismus measurements were performed. Due to loss of follow-up, 32 patients were excluded which resulted in 40 out of 72 patients remaining in the study. RESULTS: There was no statistical difference in using a drain on swelling and trismus on the third and tenth day (p > 0.05). Pain was slightly worse on the third day on the treatment side, but the difference was not significant (p > 0.05). We observed no differences in the number of wound infections. CONCLUSIONS: The insertion of a rubber drain does not have any influence on swelling, pain or trismus and has no impact on the number of wound infections. CLINICAL RELEVANCE: The use of a rubber drain cannot be recommended as no reduction of postoperative discomfort was detected. FAU - Katz, Marie Sophie AU - Katz MS AUID- ORCID: 0000-0001-6625-7712 AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. mkatz@ukaachen.de. FAU - Peters, Florian AU - Peters F AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. FAU - Elvers, Dirk AU - Elvers D AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. FAU - Winterhalder, Philipp AU - Winterhalder P AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. FAU - Kniha, Kristian AU - Kniha K AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. FAU - Möhlhenrich, Stephan Christian AU - Möhlhenrich SC AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. AD - Department of Orthodontics, University of Witten/ Herdecke, Alfred-Herrhausen-Straße 50, 58448, Witten, Germany. FAU - Hölzle, Frank AU - Hölzle F AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. FAU - Modabber, Ali AU - Modabber A AD - Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200721 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - D MH - Drainage/*methods MH - Edema/etiology/prevention & control MH - Humans MH - Mandible/surgery MH - *Molar, Third/diagnostic imaging/surgery MH - Mouth MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/prevention & control MH - Tooth Extraction/adverse effects MH - *Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control OTO - NOTNLM OT - Face scan OT - Postoperative pain OT - Swelling OT - Third molar OT - Trismus OT - Wisdom teeth OT - Wound infection EDAT- 2020/07/22 06:00 MHDA- 2021/01/08 06:00 CRDT- 2020/07/22 06:00 PHST- 2020/04/19 00:00 [received] PHST- 2020/07/14 00:00 [accepted] PHST- 2020/07/22 06:00 [pubmed] PHST- 2021/01/08 06:00 [medline] PHST- 2020/07/22 06:00 [entrez] AID - 10.1007/s00784-020-03464-5 [pii] AID - 10.1007/s00784-020-03464-5 [doi] PST - ppublish SO - Clin Oral Investig. 2021 Jan;25(1):345-353. doi: 10.1007/s00784-020-03464-5. Epub 2020 Jul 21. PMID- 24195796 OWN - NLM STAT- MEDLINE DCOM- 20140902 LR - 20181113 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 14 DP - 2013 Nov 6 TI - Effect of low-level laser therapy on the post-surgical inflammatory process after third molar removal: study protocol for a double-blind randomized controlled trial. PG - 373 LID - 10.1186/1745-6215-14-373 [doi] AB - BACKGROUND: Low-level laser therapy (LLLT) has been shown to modulate the inflammatory process without adverse effects , by reducing pain and swelling and promoting the repair of damaged tissues. Because pain, swelling and muscle spasm are complications found in virtually all patients following oral surgery for the removal of impacted teeth, this model has been widely used to evaluate the effects of LLLT on the inflammatory process involving bone and, connective tissue and the muscles involved in mastication. METHODS/DESIGN: After meeting the eligibility criteria, 60 patients treated at a Specialty Dental Center for the removal of impacted lower third molars will be randomly divided into five groups according to the type of laser therapy used at the end of surgery (intraoral irradiation with 660 nm laser; extraoral irradiation with 660 nm laser; intraoral irradiation with 808 nm laser; extraoral irradiation with 808 nm laser and no irradiation). To ensure that patients are blinded to the type of treatment they are receiving, the hand piece of the laser apparatus will be applied both intraorally and extraorally to all participants, but the device will be turned on only at the appropriate time, as determined by the randomization process. At 2 and 7 days after surgery, the patients will be evaluated by three blinded evaluators who will measure of swelling, mouth opening (muscle spasm evaluation) and pain (using two different pain scales). The 14-item Oral Health Impact Profile (OHIP-14) will be used to assess QOL. All data will be analyzed with respect to the normality of distribution using the Shapiro-Wilk test. Statistically significant differences between the experimental groups will be determined using analysis of variance, followed by a suitable post hoc test, when necessary. The significance level will be set at α = 0.05. DISCUSSION: The lack of standardization in studies with regard to the samples, methods and LLLT parameters complicates the determination of the actual effect of laser therapy on this model. The present study aims to provide a randomized, controlled, double-blind trial to compare four different LLLT parameters in relation to the outcomes of pain, swelling and muscle spasm following surgery for the extraction of impacted third molars and evaluate the effects os surgery on patients' quality os life (QOL). TRIAL REGISTRATION: Brazilian Registry of Clinical Trials - Rebec (RBR-6XSB5H). FAU - Oliveira Sierra, Simone AU - Oliveira Sierra S FAU - Melo Deana, Alessandro AU - Melo Deana A FAU - Mesquita Ferrari, Raquel Agnelli AU - Mesquita Ferrari RA FAU - Maia Albarello, Priscilla AU - Maia Albarello P FAU - Bussadori, Sandra Kalil AU - Bussadori SK FAU - Santos Fernandes, Kristianne Porta AU - Santos Fernandes KP AD - Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), Rua Vergueiro, 235, São Paulo, SP CEP: 01504-001, Brazil. kristianneporta@gmail.com. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20131106 TA - Trials JT - Trials JID - 101263253 SB - IM MH - Brazil MH - Clinical Protocols MH - Double-Blind Method MH - Facial Pain/etiology/prevention & control MH - Humans MH - Inflammation/diagnosis/etiology/*prevention & control MH - Low-Level Light Therapy/adverse effects/*methods MH - Masticatory Muscles/physiopathology/radiation effects MH - Molar, Third/*surgery MH - Pain Measurement MH - Quality of Life MH - *Research Design MH - Spasm/etiology/physiopathology/prevention & control MH - Surveys and Questionnaires MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Treatment Outcome PMC - PMC3832037 EDAT- 2013/11/08 06:00 MHDA- 2014/09/03 06:00 CRDT- 2013/11/08 06:00 PHST- 2013/04/04 00:00 [received] PHST- 2013/10/21 00:00 [accepted] PHST- 2013/11/08 06:00 [entrez] PHST- 2013/11/08 06:00 [pubmed] PHST- 2014/09/03 06:00 [medline] AID - 1745-6215-14-373 [pii] AID - 10.1186/1745-6215-14-373 [doi] PST - epublish SO - Trials. 2013 Nov 6;14:373. doi: 10.1186/1745-6215-14-373. PMID- 24589954 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20181202 IS - 1972-6007 (Electronic) IS - 0009-9074 (Linking) VI - 165 IP - 1 DP - 2014 TI - Which route of antibiotic administration should be used for third molar surgery? A split-mouth study to compare intramuscular and oral intake. PG - e12-6 LID - 10.7471/CT.2014.1665 [doi] AB - OBJECTIVE: To compare the effectiveness of two different routes of antibiotic administration in preventing septic complications in patients undergoing third molar extraction. MATERIALS AND METHODS: Twenty-four healthy patients requiring bilateral surgical removal of impacted mandibular third molars were successfully enrolled for this study. Depth of impaction, angulation, and relationship of the lower third molars with the mandibular branch had to be overlapping on both sides. A split-mouth design was chosen, so each patient underwent both the first and second surgeries, having for each extraction a different antibiotic route of administration. The second extraction was carried out 1 month later. To compare the effects of the two routes of antibiotic administration, inflammatory parameters, such as edema, trismus, pain, fever, dysphagia and lymphadenopathy were evaluated 2 and 7 days after surgery. Side effects of each therapy were evaluated 48 h after surgery. RESULTS: Oral and intramuscular antibiotic therapies overlap in preventing post-operative complications in dental surgery (p>0.05), even if the oral intake, seems to promote the onset of significant gastrointestinal disorders (p=0.003). CONCLUSIONS: This study could help dentists in their ordinary practice to choose the right route of antibiotic administration in the third molar surgery. At the same effectiveness, the higher cost and the minor compliance of the patient seem not to justify a routine antibiotic intramuscular therapy, reserving it for patients with gastrointestinal disorders. FAU - Crincoli, V AU - Crincoli V AD - Interdisciplinary Department of Medicine, University of Bari. FAU - Di Comite, M AU - Di Comite M AD - Department of Basic Medical Sciences - NOS, University of Bari. FAU - Di Bisceglie, M B AU - Di Bisceglie MB AD - Interdisciplinary Department of Medicine, University of Bari. FAU - Petruzzi, M AU - Petruzzi M AD - Interdisciplinary Department of Medicine, University of Bari. FAU - Fatone, L AU - Fatone L AD - Interdisciplinary Department of Medicine, University of Bari. FAU - De Biase, C AU - De Biase C AD - Interdisciplinary Department of Medicine, University of Bari. FAU - Tecco, S AU - Tecco S AD - Department of Oral Medical Sciences and Biotechnologies, University of Chieti, Italy. FAU - Festa, F AU - Festa F AD - Department of Oral Medical Sciences and Biotechnologies, University of Chieti, Italy. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Italy TA - Clin Ter JT - La Clinica terapeutica JID - 0372604 RN - 0 (Anti-Bacterial Agents) RN - 23521W1S24 (Clavulanic Acid) RN - 804826J2HU (Amoxicillin) RN - IHS69L0Y4T (Cefazolin) SB - IM MH - Administration, Cutaneous MH - Adult MH - Amoxicillin/administration & dosage MH - Anti-Bacterial Agents/*administration & dosage/therapeutic use MH - Cefazolin/administration & dosage MH - Clavulanic Acid/administration & dosage MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Molar, Third/*surgery MH - Postoperative Complications MH - Prospective Studies MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2014/03/05 06:00 MHDA- 2016/12/15 06:00 CRDT- 2014/03/05 06:00 PHST- 2014/03/05 06:00 [entrez] PHST- 2014/03/05 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - 10.7471/CT.2014.1665 [doi] PST - ppublish SO - Clin Ter. 2014;165(1):e12-6. doi: 10.7471/CT.2014.1665. PMID- 22521671 OWN - NLM STAT- MEDLINE DCOM- 20130527 LR - 20131121 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 41 IP - 8 DP - 2012 Aug TI - Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. PG - 1005-9 LID - 10.1016/j.ijom.2011.12.028 [doi] AB - The aim of this study was to compare the analgesic and anti-inflammatory effects of preoperative and postoperative administration of ibuprofen after the surgical removal of impacted lower third molars. A triple-blind, randomized, placebo-controlled clinical trial of 120 patients requiring the surgical removal of lower third molars was performed. The subjects were randomized into the experimental group (patients were administered 600 mg of ibuprofen (p.o.) 1h before the surgical procedure, followed by placebo just after the end of the operation) or into the control group (subjects received the same medication but the administration sequence was reversed). Pain was assessed using visual analogue scales, and consumption of rescue analgesic. The facial swelling and trismus were evaluated by measuring facial reference distances and maximum mouth opening. There were no significant differences between the two study groups regarding postoperative pain, rescue analgesics consumption, facial swelling and trismus. There was a slightly higher need for rescue analgesics in the experimental group. The preoperative intake of ibuprofen does not seem to reduce pain, facial swelling and trismus after impacted lower third molar removal when compared to the postoperative administration of the same drug. CI - Copyright © 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Aznar-Arasa, L AU - Aznar-Arasa L AD - Faculty of Dentistry, University of Barcelona, Spain. FAU - Harutunian, K AU - Harutunian K FAU - Figueiredo, R AU - Figueiredo R FAU - Valmaseda-Castellón, E AU - Valmaseda-Castellón E FAU - Gay-Escoda, C AU - Gay-Escoda C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120420 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics) RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adult MH - Analgesics/therapeutic use MH - Analgesics, Non-Narcotic/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Edema/*etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Operative Time MH - Osteotomy/methods MH - Pain Measurement MH - Pain, Postoperative/*etiology MH - Placebos MH - *Postoperative Complications MH - *Premedication MH - Range of Motion, Articular/physiology MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Trismus/etiology MH - Young Adult EDAT- 2012/04/24 06:00 MHDA- 2013/05/29 06:00 CRDT- 2012/04/24 06:00 PHST- 2011/06/02 00:00 [received] PHST- 2011/10/14 00:00 [revised] PHST- 2011/12/19 00:00 [accepted] PHST- 2012/04/24 06:00 [entrez] PHST- 2012/04/24 06:00 [pubmed] PHST- 2013/05/29 06:00 [medline] AID - S0901-5027(11)01601-8 [pii] AID - 10.1016/j.ijom.2011.12.028 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2012 Aug;41(8):1005-9. doi: 10.1016/j.ijom.2011.12.028. Epub 2012 Apr 20. PMID- 32701926 OWN - NLM STAT- MEDLINE DCOM- 20210302 LR - 20210325 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 26 IP - 2 DP - 2021 Mar 1 TI - Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mouth, randomised controlled trial. PG - e156-e163 LID - 10.4317/medoral.24094 [doi] AB - BACKGROUND: The objective of the present study was to compare the efficacy of different doses of methylprednisolone on postoperative sequelae and quality of life (QoL) following surgical removal of mandibular third molars (SRM3). MATERIAL AND METHODS: Fifty-two patients (16 men and 36 women, mean age 25.9 years, range: 18-39) with bilateral impacted mandibular third molars were randomly allocated into intraoperative muscular injection of either 20mg, 30mg, 40mg methylprednisolone or saline injection. Baseline measurements were obtained preoperatively and compared with assessment after one day, three days, seven days and one month. Pain and trismus were estimated by visual analog scale score and interincisal mouth opening, respectively. Subjective assessment of QoL included Oral Health Impact Profile (OHIP-14). Descriptive and generalized estimating equation analyses were made and expressed as mean values with a 95% confidence interval. RESULTS: Methylprednisolone revealed no significant differences in pain, trismus and QoL compared with placebo. Higher prevalence of postoperative pain and worsening in QoL were observed with increased age (P=0.00). Smoking and increased time of surgery decreased mouth opening in the early healing phase (P=0.00). CONCLUSIONS: The present study revealed no significant improvement of methylprednisolone on postoperative sequelae and QoL following SRM3 compared with placebo. FAU - Larsen, M-K AU - Larsen MK AD - Department of Oral and Maxillofacial Surgery Aalborg University Hospital 18-22 Hobrovej, DK-9000 Aalborg, Denmark marie.kjaergaard@rn.dk. FAU - Kofod, T AU - Kofod T FAU - Duch, K AU - Duch K FAU - Starch-Jensen, T AU - Starch-Jensen T LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20210301 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adolescent MH - Adult MH - Double-Blind Method MH - Edema MH - Female MH - Humans MH - Male MH - Methylprednisolone/therapeutic use MH - Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - Prospective Studies MH - *Quality of Life MH - Tooth Extraction MH - *Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control MH - Young Adult PMC - PMC7980302 COIS- Conflicts of interest None declared. EDAT- 2020/07/24 06:00 MHDA- 2021/03/03 06:00 CRDT- 2020/07/24 06:00 PHST- 2020/06/16 00:00 [received] PHST- 2020/07/10 00:00 [accepted] PHST- 2020/07/24 06:00 [pubmed] PHST- 2021/03/03 06:00 [medline] PHST- 2020/07/24 06:00 [entrez] AID - 24094 [pii] AID - 10.4317/medoral.24094 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2021 Mar 1;26(2):e156-e163. doi: 10.4317/medoral.24094. PMID- 25922858 OWN - NLM STAT- MEDLINE DCOM- 20150630 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 2 DP - 2015 Feb 9 TI - Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery. PG - CD009961 LID - 10.1002/14651858.CD009961.pub2 [doi] AB - BACKGROUND: In people with haemophilia or other congenital bleeding disorders undergoing surgical interventions, haemostatic treatment is needed in order to correct the underlying coagulation abnormalities and minimise the bleeding risk. This treatment varies according to the specific haemostatic defect, its severity and the type of surgical procedure. The aim of treatment is to ensure adequate haemostatic coverage for as long as the bleeding risk persists and until wound healing is complete. OBJECTIVES: To assess the effectiveness and safety of different haemostatic regimens (type, dose and duration, modality of administration and target haemostatic levels) administered in people with haemophilia or other congenital bleeding disorders for preventing bleeding complications during and after surgical procedures. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles and reviews.Date of the last search: 20 November 2014. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials comparing any hemostatic treatment regimen to no treatment or to another active regimen in children and adults with haemophilia or other congenital bleeding disorders undergoing any surgical intervention. DATA COLLECTION AND ANALYSIS: Two authors independently assessed trials (eligibility and risks of bias) and extracted data. Meta-analyses were performed on available and relevant data. MAIN RESULTS: Of the 16 identified trials, four (112 participants) were eligible for inclusion.Two trials evaluated 59 people with haemophilia A and B undergoing 63 dental extractions. Trials compared the use of a different type (tranexamic acid or epsilon-aminocaproic acid) and regimen of antifibrinolytic agents as haemostatic support to the initial replacement treatment. Neither trial specifically addressed mortality (one of this review's primary outcomes); however, in the frame of safety assessments, no fatal adverse events were reported. The second primary outcome of blood loss was assessed after surgery and these trials showed the reduction of blood loss and requirement of post-operative replacement treatment in people receiving antifibrinolytic agents compared with placebo. The remaining primary outcome of need for re-intervention was not reported by either trial.Two trials reported on 53 people with haemophilia A and B with inhibitors treated with different regimens of recombinant activated factor VII (rFVIIa) for haemostatic coverage of 33 major and 20 minor surgical interventions. Neither of the included trials specifically addressed any of the review's primary outcomes (mortality, blood loss and need for re-intervention). In one trial a high-dose rFVIIa regimen (90 μg/kg) was compared with a low-dose regimen (35 μg/kg); the higher dose showed increased haemostatic efficacy, in particular in major surgery, with shorter duration of treatment, similar total dose of rFVIIa administered and similar safety levels. In the second trial, bolus infusion and continuous infusion of rFVIIa were compared, showing similar haemostatic efficacy, duration of treatment and safety. AUTHORS' CONCLUSIONS: There is insufficient evidence from randomised controlled trials to assess the most effective and safe haemostatic treatment to prevent bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgical procedures. Ideally large, adequately powered, and well-designed randomised controlled trials would be needed, in particular to address the cost-effectiveness of such demanding treatments in the light of the increasing present economic constraints, and to explore the new challenge of ageing patients with haemophilia or other congenital bleeding disorders. However, performing such trials is always a complex task in this setting and presently does not appear to be a clinical and research priority. Indeed, major and minor surgeries are effectively and safely performed in these individuals in clinical practice, with the numerous national and international recommendations and guidelines providing regimens for treatment in this setting mainly based on data from observational, uncontrolled studies. FAU - Coppola, Antonio AU - Coppola A FAU - Windyga, Jerzy AU - Windyga J FAU - Tufano, Antonella AU - Tufano A FAU - Yeung, Cindy AU - Yeung C FAU - Di Minno, Matteo Nicola Dario AU - Di Minno MN LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20150209 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Antifibrinolytic Agents) RN - 0 (Recombinant Proteins) RN - 6T84R30KC1 (Tranexamic Acid) RN - AC71R787OV (recombinant FVIIa) RN - EC 3.4.21.21 (Factor VIIa) RN - U6F3787206 (Aminocaproic Acid) SB - IM CIN - Evid Based Dent. 2015 Sep;16(3):90-1. PMID: 26492808 MH - Aminocaproic Acid/therapeutic use MH - Antifibrinolytic Agents/*therapeutic use MH - Blood Loss, Surgical/*prevention & control MH - Factor VIIa/therapeutic use MH - Hemophilia A/*drug therapy MH - Hemophilia B/*drug therapy MH - Hemostasis, Surgical/*methods MH - Humans MH - Randomized Controlled Trials as Topic MH - Recombinant Proteins/therapeutic use MH - *Surgical Procedures, Operative MH - *Tooth Extraction MH - Tranexamic Acid/therapeutic use EDAT- 2015/04/30 06:00 MHDA- 2015/07/01 06:00 CRDT- 2015/04/30 06:00 PHST- 2015/04/30 06:00 [entrez] PHST- 2015/04/30 06:00 [pubmed] PHST- 2015/07/01 06:00 [medline] AID - 10.1002/14651858.CD009961.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2015 Feb 9;(2):CD009961. doi: 10.1002/14651858.CD009961.pub2. PMID- 14663808 OWN - NLM STAT- MEDLINE DCOM- 20040115 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 61 IP - 12 DP - 2003 Dec TI - Tranexamic acid mouthwash versus autologous fibrin glue in patients taking warfarin undergoing dental extractions: a randomized prospective clinical study. PG - 1432-5 AB - PURPOSE: The aim of this prospective study was to compare the effectiveness of a 4.8% tranexamic acid mouthwash versus an autologous fibrin glue preparation to control hemostasis in patients therapeutically anticoagulated with warfarin who required dental extractions without interruption of their treatment. PATIENTS AND METHODS: The 49 patients who underwent 152 dental extractions were randomly allocated to 2 groups: Group A were required to rinse with 10 mL of a 4.8% tranexamic acid solution 4 times a day for 7 days postoperatively. Group B received autologous fibrin glue intraoperatively. The international normalized ratio was measured on the day of the procedure. All procedures were performed on an ambulatory basis by the same surgeon. RESULTS: Of the 49 patients, 2 presented with postoperative bleeding (4%). Both patients were from the autologous fibrin glue group and were found to have grossly elevated international normalized ratios on the day of the bleeding that was unaccounted for. CONCLUSIONS: This study supports the consensus that dental extractions can be performed without modification of oral anticoagulant treatment. Local hemostasis with an absorbable oxidized cellulose mesh, tranexamic acid, and sutures is the more cost efficient of the 2 methods compared; however, autologous fibrin glue has an important role in patients unable to use a mouthwash effectively. FAU - Carter, Glen AU - Carter G AD - Oral and Maxillofacial Surgery Unit, Royal Adelaide Hospital, University of Adelaide, Australia. FAU - Goss, Alastair AU - Goss A FAU - Lloyd, John AU - Lloyd J FAU - Tocchetti, Ric AU - Tocchetti R LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anticoagulants) RN - 0 (Fibrin Tissue Adhesive) RN - 0 (Hemostatics) RN - 0 (Mouthwashes) RN - 5Q7ZVV76EI (Warfarin) RN - 6T84R30KC1 (Tranexamic Acid) SB - AIM SB - D SB - IM MH - Adult MH - Aged MH - Anticoagulants/administration & dosage MH - Blood Loss, Surgical/prevention & control MH - *Dental Care for Chronically Ill MH - Drug Interactions MH - Female MH - Fibrin Tissue Adhesive/*therapeutic use MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Mouthwashes/*therapeutic use MH - Oral Hemorrhage/etiology/*prevention & control MH - Oral Surgical Procedures/adverse effects MH - Polypharmacy MH - Postoperative Hemorrhage/etiology/prevention & control MH - Prospective Studies MH - Tooth Extraction/adverse effects MH - Tranexamic Acid/*therapeutic use MH - Treatment Outcome MH - Warfarin/*administration & dosage EDAT- 2003/12/10 05:00 MHDA- 2004/01/16 05:00 CRDT- 2003/12/10 05:00 PHST- 2003/12/10 05:00 [pubmed] PHST- 2004/01/16 05:00 [medline] PHST- 2003/12/10 05:00 [entrez] AID - S0278239103008437 [pii] AID - 10.1016/j.joms.2003.01.001 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2003 Dec;61(12):1432-5. doi: 10.1016/j.joms.2003.01.001. PMID- 25662551 OWN - NLM STAT- MEDLINE DCOM- 20160225 LR - 20190609 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 20 IP - 3 DP - 2015 May 1 TI - Effect of the suture technique on postoperative pain, swelling and trismus after removal of lower third molars: A randomized clinical trial. PG - e372-7 AB - BACKGROUND: To evaluate the intensity of pain, swelling and trismus after the removal of impacted lower third molars comparing two different suture techniques of the triangular flap: the complete suture of the distal incision and relieving incision and the partial suture with only one suture knot for closure of the corner of the flap and the closure of the distal incision, without suturing the relieving incision. MATERIAL AND METHODS: A prospective, randomized, cross-over clinical trial was conducted in 40 patients aged from 18 to 45 years who underwent surgical extraction of impacted lower third molars at the Department of Oral Surgery in the Odontological Hospital of the University of Barcelona during the year 2011. Patients were randomly divided in 2 groups. Two different techniques (hermetical closure and partial closure of the wound) were performed separated by a one month washout period in each patient. Postoperative pain, swelling and trismus were evaluated prior to the surgical procedure and also at 2 and 7 days postoperatively. RESULTS: No statistically significant differences were observed for pain (p<0.06), trismus (p<0.71) and swelling (p<0.05) between the test and the control group. However, the values of the three parameters related to the test group were lower than those for the control group. CONCLUSIONS: Partial closure of the flap without suturing the relieving incision after surgical extraction of lower third molars reduces operating time and it does not produce any postoperative complications compared with complete closure of the wound. FAU - Gay-Escoda, Cosme AU - Gay-Escoda C AD - Centro Médico Teknon, C/ Vilana 12, 08022, Barcelona, Spain, cgay@ub.edu. FAU - Gómez-Santos, Laila AU - Gómez-Santos L FAU - Sánchez-Torres, Alba AU - Sánchez-Torres A FAU - Herráez-Vilas, José-María AU - Herráez-Vilas JM LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150501 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 SB - D SB - IM MH - Adolescent MH - Adult MH - Edema/*etiology/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*etiology/*prevention & control MH - Prospective Studies MH - *Suture Techniques MH - Tooth Extraction/*adverse effects MH - Trismus/*etiology/*prevention & control MH - Young Adult PMC - PMC4464926 COIS- Conflict of interest statement: The authors have declared that no conflict of interest exist. EDAT- 2015/02/11 06:00 MHDA- 2016/02/26 06:00 CRDT- 2015/02/10 06:00 PHST- 2014/08/02 00:00 [received] PHST- 2015/01/02 00:00 [accepted] PHST- 2015/02/10 06:00 [entrez] PHST- 2015/02/11 06:00 [pubmed] PHST- 2016/02/26 06:00 [medline] AID - 20307 [pii] AID - 10.4317/medoral.20307 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2015 May 1;20(3):e372-7. doi: 10.4317/medoral.20307. PMID- 29796741 OWN - NLM STAT- MEDLINE DCOM- 20190823 LR - 20190823 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 22 IP - 3 DP - 2018 Sep TI - Comparative study of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. PG - 261-266 LID - 10.1007/s10006-018-0696-8 [doi] AB - AIM: Aim of the study is to compare the primary and secondary healing after surgical removal of impacted mandibular third molars, in terms of swelling, severity of pain, trismus, and periodontal healing between two types of closure. MATERIALS AND METHODS: A total of 60 patients, divided into two groups randomly: group A, with 30 patients in which primary closure was done; group B, with 30 patients in which secondary closure was done. A comparison between two groups was done in terms of postoperative pain, swelling, trismus at first, third, and seventh postoperative days, and periodontal healing near adjacent second molar after 6 months. RESULTS: The swelling and pain in group A were greater than that in group B, with a statistically significant difference (p < 0.05). Mouth opening is greater in group B compared to group A. There is no significant difference in periodontal healing in between two groups after 6 months. Complication like alveolar osteitis was noted in 1 patient (3.3%) in group B. CONCLUSION: We conclude that secondary closure was better than primary closure in terms of postoperative pain, swelling, and trismus. Irrespective of any closure technique, there is no difference in terms of periodontal healing. FAU - Pachipulusu, Pavan Kumar AU - Pachipulusu PK AD - Department of Oral and Maxillofacial Surgery, J.S.S. Dental College & Hospital, Jagadguru Sri Shivarathreeshwara University, 570015, Mysuru, Karnataka, India. FAU - S, Manjula AU - S M AD - Department of Oral and Maxillofacial Surgery, J.S.S. Dental College & Hospital, Jagadguru Sri Shivarathreeshwara University, 570015, Mysuru, Karnataka, India. manjulamaxfac@gmail.com. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20180523 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 MH - Adolescent MH - Adult MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/pathology/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Suture Techniques/*instrumentation MH - Tooth Extraction/*methods MH - Tooth, Impacted/pathology/*surgery MH - Treatment Outcome MH - Trismus/prevention & control MH - Wound Closure Techniques/*instrumentation MH - Wound Healing OTO - NOTNLM OT - Impaction OT - Periodontal healing OT - Primary healing OT - Secondary healing OT - Trismus OT - VAS EDAT- 2018/05/26 06:00 MHDA- 2019/08/24 06:00 CRDT- 2018/05/26 06:00 PHST- 2017/11/12 00:00 [received] PHST- 2018/04/24 00:00 [accepted] PHST- 2018/05/26 06:00 [pubmed] PHST- 2019/08/24 06:00 [medline] PHST- 2018/05/26 06:00 [entrez] AID - 10.1007/s10006-018-0696-8 [pii] AID - 10.1007/s10006-018-0696-8 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2018 Sep;22(3):261-266. doi: 10.1007/s10006-018-0696-8. Epub 2018 May 23. PMID- 31607400 OWN - NLM STAT- MEDLINE DCOM- 20200306 LR - 20200306 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 57 IP - 10 DP - 2019 Dec TI - Alveolar repair after the use of piezosurgery in the removal of lower third molars: a prospective clinical, randomised, double-blind, split-mouth study. PG - 1068-1073 LID - S0266-4356(19)30386-9 [pii] LID - 10.1016/j.bjoms.2019.09.017 [doi] AB - The objective of this study was to evaluate the use of piezosurgery for osteotomy and odontosection in the repair of the alveoli four months after exodontia. Fifteen young patients who needed third molars extracted were included. During the extractions, one of the teeth was included in the Piezo group, in which ultrasound motor tips were used in both procedures. The other tooth was removed with a conventional rotary instrument. The values of density of the repair regions of the right and left third molars were compared using digital panoramic radiographs. There were no significant differences (p>0.05): piezo group mean (SD) 125.7 (15.4) and control group 126.7 (21.2). The bone density of the alveoli after extraction of the lower third molars with rotary instruments and surgical ultrasound was similar in both groups. CI - Copyright © 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - de Freitas Silva, L AU - de Freitas Silva L AD - The Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. FAU - Ribeiro de Carvalho Reis, E N AU - Ribeiro de Carvalho Reis EN AD - The Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. FAU - Oliveira Souza, B C AU - Oliveira Souza BC AD - The Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. FAU - Egas, L S AU - Egas LS AD - The Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. FAU - Aranega, A M AU - Aranega AM AD - The Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. FAU - Ponzoni, D AU - Ponzoni D AD - The Department of Surgery and Integrated Clinic, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. Electronic address: dponzoni@foa.unesp.br. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20191010 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Double-Blind Method MH - Humans MH - Mandible MH - *Molar, Third MH - Pain, Postoperative MH - Piezosurgery MH - Prospective Studies MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - *Bone Density OT - *Osteotomy OT - *Piezosurgery OT - *Third Molar OT - *exodontia EDAT- 2019/10/15 06:00 MHDA- 2020/03/07 06:00 CRDT- 2019/10/15 06:00 PHST- 2018/09/20 00:00 [received] PHST- 2019/09/18 00:00 [accepted] PHST- 2019/10/15 06:00 [pubmed] PHST- 2020/03/07 06:00 [medline] PHST- 2019/10/15 06:00 [entrez] AID - S0266-4356(19)30386-9 [pii] AID - 10.1016/j.bjoms.2019.09.017 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2019 Dec;57(10):1068-1073. doi: 10.1016/j.bjoms.2019.09.017. Epub 2019 Oct 10. PMID- 27583530 OWN - NLM STAT- MEDLINE DCOM- 20171128 LR - 20171128 IS - 1827-174X (Electronic) IS - 0026-4970 (Linking) VI - 66 IP - 1 DP - 2017 Feb TI - Microbiological analysis of bacterial plaque on three different threads in oral surgery. PG - 28-34 LID - 10.23736/S0926-4970.16.03966-7 [doi] AB - BACKGROUND: Suture is the final act of most oral surgery procedures. The quality of healing after the operation depends on its efficiency. Sutures must not cause inflammation - neither directly nor indirectly. The objective of this study is to compare the bacterial colonization on different suture materials after a third molar extraction. METHODS: Thirty patients were randomly selected among people going under third molar extraction; they were divided into 3 groups and one suture type was used on each group. After 7 days distal stitches were removed by a single operator, placed in physiologic solution and analyzed after 2 or 3 hours. Patients followed the same postsurgical protocols; materials used were: Ethicon Silk® 4/0, B. Braun Dafilon® 4/0, and B. Braun Safil® 4/0. RESULTS: The amount of cocci and bacilli on the sutures analyzed shows that silk (Ethicon Silk) is the higher level of retention material where monofilament (B. Braun Dafilon) is the lower. There is a difference between monofilament and polyglycolide (B. Braun Safil), as the former is less retentive than the latter, although not significantly so. CONCLUSIONS: A less plaque retention, and consequently a fewer bacterial presence, is crucial to minimize the inflammatory process and allow a better tissue healing. Since the capability of brushing and, of course, the final personal hygiene depends on multiple variables, we must use surgical protocols able to minimize the effect of improper cleaning on the healing process: this statement implies the use of low plaque retention materials. The use of monofilament or polyglycolide threads in sutures can help reducing bacterial concentration and therefore promotes a faster and better healing. FAU - Bucci, Marco AU - Bucci M AD - Department of Oral Rehabilitation, Italian Institute of Stomatology, University of Milan, Milan, Italy - dr.marcobucci@gmail.com. FAU - Borgonovo, Andrea AU - Borgonovo A AD - Department of Oral Rehabilitation, Italian Institute of Stomatology, University of Milan, Milan, Italy. FAU - Bianchi, Albino AU - Bianchi A AD - Department of Oral Rehabilitation, Italian Institute of Stomatology, University of Milan, Milan, Italy. FAU - Zanellato, Anna AU - Zanellato A AD - Department of Oral Rehabilitation, Italian Institute of Stomatology, University of Milan, Milan, Italy. FAU - Re, Dino AU - Re D AD - Department of Oral Rehabilitation, Italian Institute of Stomatology, University of Milan, Milan, Italy. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20160901 PL - Italy TA - Minerva Stomatol JT - Minerva stomatologica JID - 0421071 RN - 0 (Nylons) RN - 0 (Silk) RN - 26009-03-0 (Polyglycolic Acid) SB - D SB - IM MH - Adolescent MH - Adult MH - Bacteria/*isolation & purification MH - *Biofilms MH - Dental Plaque/*microbiology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - *Nylons MH - Oral Hygiene MH - *Polyglycolic Acid MH - Sampling Studies MH - *Silk MH - Sutures/*microbiology MH - *Tooth Extraction MH - Wound Healing MH - Young Adult EDAT- 2016/09/02 06:00 MHDA- 2017/11/29 06:00 CRDT- 2016/09/02 06:00 PHST- 2016/09/02 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] PHST- 2016/09/02 06:00 [entrez] AID - R18Y9999N00A16090102 [pii] AID - 10.23736/S0926-4970.16.03966-7 [doi] PST - ppublish SO - Minerva Stomatol. 2017 Feb;66(1):28-34. doi: 10.23736/S0926-4970.16.03966-7. Epub 2016 Sep 1. PMID- 16876058 OWN - NLM STAT- MEDLINE DCOM- 20060816 LR - 20131121 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 102 IP - 2 DP - 2006 Aug TI - Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study. PG - 169-74 AB - OBJECTIVE: Comparison of the clinical efficacy of 4% articaine in relation to 2% mepivacaine, both with 1:100,000 epinephrine, in the prevention of postoperative pain after lower third molar removal. STUDY DESIGN: Twenty patients underwent removal of bilateral lower third molars under local anesthesia (articaine or mepivacaine) in 2 separate appointments, in a double-blind, randomized, and crossed manner. Objective and subjective parameters were recorded for paired comparison of postoperative courses. RESULTS: Duration of analgesia provided by articaine and mepivacaine was 198.00 +/- 25.86, and 125.40 +/- 13.96 min, respectively (P = .02), whereas the duration of anesthesia was 273.80 +/- 15.94 and 216.85 +/- 20.15 min, respectively (P = .06). Both solutions exerted no important effects upon arterial pressure, heart rate, or oxygen saturation (P > .05). CONCLUSIONS: Articaine provides a longer period of analgesic effect and a tendency for a longer period of anesthesia as compared to mepivacaine. The presence of a vasoconstrictor agent in local anesthetic solutions does not seem to influence hemodynamic parameters during lower third molar removal in healthy subjects. FAU - Colombini, Bella L AU - Colombini BL AD - Bauru School of Dentistry, São Paulo, Brazil. FAU - Modena, Karin C S AU - Modena KC FAU - Calvo, Adriana M AU - Calvo AM FAU - Sakai, Vivien T AU - Sakai VT FAU - Giglio, Fernando P M AU - Giglio FP FAU - Dionísio, Thiago J AU - Dionísio TJ FAU - Trindade, Alceu S Jr AU - Trindade AS Jr FAU - Lauris, José R P AU - Lauris JR FAU - Santos, Carlos F AU - Santos CF LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20060324 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - B6E06QE59J (Mepivacaine) RN - D3SQ406G9X (Carticaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/*methods MH - Anesthesia, Local MH - Anesthetics, Local/*administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Carticaine/*administration & dosage MH - Cross-Over Studies MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mepivacaine/*administration & dosage MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Piroxicam/therapeutic use MH - Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2006/08/01 09:00 MHDA- 2006/08/17 09:00 CRDT- 2006/08/01 09:00 PHST- 2005/07/01 00:00 [received] PHST- 2005/08/16 00:00 [revised] PHST- 2005/09/06 00:00 [accepted] PHST- 2006/08/01 09:00 [pubmed] PHST- 2006/08/17 09:00 [medline] PHST- 2006/08/01 09:00 [entrez] AID - S1079-2104(05)00777-8 [pii] AID - 10.1016/j.tripleo.2005.09.003 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Aug;102(2):169-74. doi: 10.1016/j.tripleo.2005.09.003. Epub 2006 Mar 24. PMID- 25561389 OWN - NLM STAT- MEDLINE DCOM- 20160115 LR - 20150209 IS - 2212-4411 (Electronic) VI - 119 IP - 3 DP - 2015 Mar TI - Does watching a video on third molar surgery increase patients' anxiety level? PG - 272-7 LID - S2212-4403(14)01341-8 [pii] LID - 10.1016/j.oooo.2014.10.012 [doi] AB - OBJECTIVE: To identify the effects of watching live taping of third molar removal on patients' anxiety levels before and after extraction. STUDY DESIGN: This study was based on a prospective, cross-sectional, observational investigation of the different patient education techniques about the effect of third molar removal on patients' anxiety level. A total of 333 patients were randomized into three groups: two study groups (for group 1, basic information was given verbally; for group 2, which was the study group, basic information was given verbally and through a movie on third molar extraction); and a control group (basic information was given verbally; it did not include information on operative procedures and recovery). Anxiety levels were assessed by using the Dental Anxiety Scale (DAS) and the Spielberger State-Trait Anxiety Inventory (STAI). Pain was assessed with a visual analog scale. Statistical analysis was performed with SPSS 16.0. RESULTS: Group 2 patients were significantly more anxious before the surgical procedure, and the most significant decreases in DAS and STAI scores were observed in that group. The age, surgery time, and education level were not correlated with anxiety or pain levels; however, female patients had high levels of anxiety (P < .05). CONCLUSION: Preoperative multimedia information increases the anxiety of patients undergoing third molar surgery. CI - Copyright © 2015 Elsevier Inc. All rights reserved. FAU - Kazancioglu, Hakki Oguz AU - Kazancioglu HO AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey. FAU - Tek, Mustafa AU - Tek M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Abant Izzet Baysal University, Bolul, Turkey. FAU - Ezirganli, Seref AU - Ezirganli S AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey. FAU - Demirtas, Nihat AU - Demirtas N AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey. Electronic address: Nhtdemirtas@gmail.com. LA - eng PT - Journal Article PT - Observational Study PT - Randomized Controlled Trial DEP - 20141108 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 SB - D SB - IM MH - Adolescent MH - Adult MH - Cross-Sectional Studies MH - Dental Anxiety/*etiology MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/psychology MH - Prospective Studies MH - Psychiatric Status Rating Scales MH - Tooth Extraction/*psychology MH - Tooth, Impacted/*surgery MH - *Videotape Recording EDAT- 2015/01/07 06:00 MHDA- 2016/01/16 06:00 CRDT- 2015/01/07 06:00 PHST- 2014/07/12 00:00 [received] PHST- 2014/09/26 00:00 [revised] PHST- 2014/10/17 00:00 [accepted] PHST- 2015/01/07 06:00 [entrez] PHST- 2015/01/07 06:00 [pubmed] PHST- 2016/01/16 06:00 [medline] AID - S2212-4403(14)01341-8 [pii] AID - 10.1016/j.oooo.2014.10.012 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Mar;119(3):272-7. doi: 10.1016/j.oooo.2014.10.012. Epub 2014 Nov 8. PMID- 20006168 OWN - NLM STAT- MEDLINE DCOM- 20100112 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 68 IP - 1 DP - 2010 Jan TI - Intranasal desmopressin versus blood transfusion in cirrhotic patients with coagulopathy undergoing dental extraction: a randomized controlled trial. PG - 138-43 LID - 10.1016/j.joms.2009.07.081 [doi] AB - PURPOSE: Cirrhotic patients waiting for liver transplantation who need dental extractions are given fresh frozen plasma and/or platelets to correct coagulopathy. This is costly and may be associated with transfusion reactions and fluid overload. We evaluated the efficacy of intranasal desmopressin as an alternative to transfusion to correct the coagulopathy of cirrhotic patients undergoing dental extraction. PATIENTS AND METHODS: Cirrhotic patients with platelet counts of 30,000 to 50,000/microL and/or international normalized ratio (INR) 2.0 to 3.0 were enrolled in a prospective, controlled, randomized clinical trial. Blood transfusion (fresh frozen plasma 10 mL/kg and/or 1 unit of single donor platelets, respectively) or intranasal desmopressin (300 microg) were given before dental extraction. A standard oral and maxillofacial surgical treatment protocol was performed by the same surgeon. Patients were followed for postextraction bleeding and side-effects over the next 24 to 48 hours. RESULTS: No significant differences were noted between the 2 groups in gender, age, INR, platelet count, creatinine, total bilirubin, ALT, albumin, MELD score, or number of teeth removed (median 3 vs 4). The number of teeth removed ranged between 1 and 31 in the desmopressin group and 1 and 22 in the transfusion group. No patients in desmopressin group required rescue blood transfusion after extraction. One patient in the transfusion group had bleeding after the procedure and required an additional transfusion. Another patient experienced an allergic reaction at the end of transfusion, which was effectively treated with diphenhydramine. Treatment associated average costs were lower for desmopressin ($700/patient) compared with transfusion ($1,173/patient). CONCLUSIONS: Intranasal desmopressin was as effective as blood transfusion in achieving hemostasis in cirrhotic patients with moderate coagulopathy undergoing dental extraction. Intranasal desmopressin was much more convenient, less expensive, and well tolerated. FAU - Stanca, Carmen M AU - Stanca CM AD - Mount Sinai Medical Center, Department of Medicine, New York, NY 10029, USA. FAU - Montazem, Andre H AU - Montazem AH FAU - Lawal, Adeyemi AU - Lawal A FAU - Zhang, Jin X AU - Zhang JX FAU - Schiano, Thomas D AU - Schiano TD LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Hemostatics) RN - ENR1LLB0FP (Deamino Arginine Vasopressin) SB - AIM SB - D SB - IM MH - Administration, Intranasal MH - Adult MH - Blood Coagulation Disorders/complications/*drug therapy MH - Blood Loss, Surgical/prevention & control MH - *Blood Transfusion MH - Deamino Arginine Vasopressin/*administration & dosage MH - Female MH - Hemostatics/*administration & dosage MH - Humans MH - International Normalized Ratio MH - Liver Cirrhosis/*blood/complications/surgery MH - Liver Transplantation MH - Male MH - Middle Aged MH - Plasma MH - Platelet Count MH - Platelet Transfusion MH - *Premedication MH - *Tooth Extraction EDAT- 2009/12/17 06:00 MHDA- 2010/01/13 06:00 CRDT- 2009/12/17 06:00 PHST- 2009/04/01 00:00 [received] PHST- 2009/07/30 00:00 [revised] PHST- 2009/07/30 00:00 [accepted] PHST- 2009/12/17 06:00 [entrez] PHST- 2009/12/17 06:00 [pubmed] PHST- 2010/01/13 06:00 [medline] AID - S0278-2391(09)01495-5 [pii] AID - 10.1016/j.joms.2009.07.081 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2010 Jan;68(1):138-43. doi: 10.1016/j.joms.2009.07.081. PMID- 17347539 OWN - NLM STAT- MEDLINE DCOM- 20070606 LR - 20191110 IS - 0970-9290 (Print) IS - 0970-9290 (Linking) VI - 18 IP - 1 DP - 2007 Jan-Mar TI - Comparison of morbidity following the removal of mandibular third molar by lingual split, surgical bur and simplified split bone technique. PG - 15-8 AB - BACKGROUND: The methods frequently used for surgical removal of impacted third molars are bur technique, lingual split and simplified split bone technique. The morbidity rates following the use of these different surgical techniques are not completely resolved. The use of a surgical method with minimum postoperative complication is needed. AIM: This study was conducted to compare the morbidity rates of the three different surgical techniques and their efficacy with regard to postoperative pain, swelling, labial and lingual sensation. MATERIALS AND METHODS: Ninety patients with a symptomatic impacted mandibular third molar with the age range of 14-62 years were divided into three groups of 30 patients each for surgical bur technique, lingual split technique and simplified split bone technique. All patients were operated by the same surgeon under local anesthesia (2% lignocaine) in the dental chair. The severity of pain and swelling was recorded on a visual analogue scale and the presence or absence of sensory disturbance at 6, 24, 48 hours and seven days after operation. The pain was scored according to a visual analogue 4-point scale. Patients were asked to indicate which side was more swollen and to record this assessment on the swelling scale. RESULTS: Lingual split technique was more painful than the other two techniques. Surgical bur technique had more swelling than the other two techniques. Labial and lingual sensations were not altered in all the techniques. CONCLUSION: The simplified split bone technique had the least morbidity than the lingual split and surgical bur technique. FAU - Praveen, G AU - Praveen G AD - Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Alapakkam Main Road, Maduravoyal, Chennai - 95, India. FAU - Rajesh, P AU - Rajesh P FAU - Neelakandan, R S AU - Neelakandan RS FAU - Nandagopal, C M AU - Nandagopal CM LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 SB - D MH - Adolescent MH - Adult MH - Edema/etiology MH - Humans MH - Lingual Nerve Injuries MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology MH - Somatosensory Disorders/etiology MH - Statistics, Nonparametric MH - Tooth Extraction/*adverse effects/*methods MH - Tooth, Impacted/*surgery EDAT- 2007/03/10 09:00 MHDA- 2007/06/07 09:00 CRDT- 2007/03/10 09:00 PHST- 2007/03/10 09:00 [pubmed] PHST- 2007/06/07 09:00 [medline] PHST- 2007/03/10 09:00 [entrez] AID - 10.4103/0970-9290.30916 [doi] PST - ppublish SO - Indian J Dent Res. 2007 Jan-Mar;18(1):15-8. doi: 10.4103/0970-9290.30916. PMID- 27893550 OWN - NLM STAT- MEDLINE DCOM- 20170411 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 28 IP - 1 DP - 2017 Jan TI - Application of Dexamethasone in the Masseter Muscle During the Surgical Removal of Lower Third Molars. PG - e43-e47 LID - 10.1097/SCS.0000000000003188 [doi] AB - PURPOSE: The aim of the present study was to analyze the effect of the application of dexamethasone in the masseter muscle during third molar surgery. METHODS: This randomized, clinical trial used dependent samples and the split-mouth method. A sample of 30 patients, with impacted or semi-impacted third molars, as well as vertical and mesioangular positions of a similar surgical difficulty (on both sides), was subjected to 2 operations: an experimental operation and a control procedure, with a 30-day wash-out. The choice of which group would be experimental or control was random. The experimental group received 8 mg of dexamethasone, which was applied directly to the masseter muscle immediately after surgery. The control group did not receive corticosteroids. Seven and 15 days after the surgery, the patients were assessed in relation to their levels of pain, trismus, and edema. RESULTS: Concerning edema and trismus, there was a significant difference (P <0.05) between the control and experimental groups. As for the pain scale, no significant differences were found between the presence or absence of corticoids. CONCLUSION: The present study concluded that the application of dexamethasone in the masseter muscle effectively reduces edema and trismus, but does not affect pain. FAU - Rocha-Neto, Alípio Miguel AU - Rocha-Neto AM AD - *Department of Oral and Maxillofacial Surgery †Orofacial Pain Department, University of Pernambuco, Recife, Brazil. FAU - Nogueira, Emerson Filipe de Carvalho AU - Nogueira EF FAU - Borba, Patrícia Mendonça AU - Borba PM FAU - Laureano-Filho, José Rodrigues AU - Laureano-Filho JR FAU - Vasconcelos, Belmiro Cavalcanti do Egito AU - Vasconcelos BC LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) SB - D MH - Adolescent MH - Adult MH - Dexamethasone/*administration & dosage MH - Edema/prevention & control MH - Female MH - Glucocorticoids/administration & dosage MH - Humans MH - Injections, Intramuscular MH - Intraoperative Period MH - Male MH - Masseter Muscle MH - Molar, Third/*surgery MH - Postoperative Complications/*prevention & control MH - Single-Blind Method MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Trismus/*prevention & control MH - Young Adult EDAT- 2016/11/29 06:00 MHDA- 2017/04/12 06:00 CRDT- 2016/11/29 06:00 PHST- 2016/11/29 06:00 [pubmed] PHST- 2017/04/12 06:00 [medline] PHST- 2016/11/29 06:00 [entrez] AID - 10.1097/SCS.0000000000003188 [doi] PST - ppublish SO - J Craniofac Surg. 2017 Jan;28(1):e43-e47. doi: 10.1097/SCS.0000000000003188. PMID- 22424708 OWN - NLM STAT- MEDLINE DCOM- 20130527 LR - 20120716 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 41 IP - 8 DP - 2012 Aug TI - Flap design and mandibular third molar surgery: a split mouth randomized clinical study. PG - 1020-4 LID - 10.1016/j.ijom.2012.02.011 [doi] AB - The aim of this study was to investigate the effects of two commonly used flap designs (envelope and triangular) used for the removal of mandibular third molars (M3) on postoperative morbidity. 19 patients with bilateral symmetrically impacted mandibular M3 were studied using a split mouth design. Swelling, pain and trismus measures were recorded on days 2, 7 and 14; periodontal indices were recorded on days 7 and 14, one final measure of probing depth on the distal aspect of the mandibular second molar (M2) was taken at the last follow up appointment. Data were analysed using the χ(2) test, the Mann-Whitney U-test and Pearson's correlations. The mean age of the patients was 21.4 ± 2.3 years (± SD). Facial swelling and the reduction in mouth opening were significantly greater in the early postoperative period (P<0.05) with pyramidal flap designs. There was no significant difference in pain scores, plaque accumulation and bleeding on probing indices between the two flap designs (P>0.05). Probing depth was significantly greater with envelope flaps in the early postoperative period (P<0.005). In conclusion, flap design in mandibular M3 surgery has an effect on postoperative recovery. CI - Copyright © 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Baqain, Z H AU - Baqain ZH AD - Faculty of Dentistry, University of Jordan, Amman, Jordan. zbaqain@ju.edu.jo FAU - Al-Shafii, A AU - Al-Shafii A FAU - Hamdan, A A AU - Hamdan AA FAU - Sawair, F A AU - Sawair FA LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20120315 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Dental Plaque/classification MH - Edema/etiology MH - Female MH - Follow-Up Studies MH - Gingival Hemorrhage/classification MH - Humans MH - Male MH - Mandible/*surgery MH - Molar/pathology MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology MH - Periodontal Index MH - Periodontal Pocket/classification MH - Postoperative Complications MH - Prospective Studies MH - *Surgical Flaps/classification MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Trismus/etiology MH - Young Adult EDAT- 2012/03/20 06:00 MHDA- 2013/05/29 06:00 CRDT- 2012/03/20 06:00 PHST- 2011/06/23 00:00 [received] PHST- 2011/12/10 00:00 [revised] PHST- 2012/02/15 00:00 [accepted] PHST- 2012/03/20 06:00 [entrez] PHST- 2012/03/20 06:00 [pubmed] PHST- 2013/05/29 06:00 [medline] AID - S0901-5027(12)00077-X [pii] AID - 10.1016/j.ijom.2012.02.011 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2012 Aug;41(8):1020-4. doi: 10.1016/j.ijom.2012.02.011. Epub 2012 Mar 15. PMID- 24121915 OWN - NLM STAT- MEDLINE DCOM- 20141204 LR - 20190608 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 19 IP - 1 DP - 2014 Jan 1 TI - Effect of the local administration of betamethasone on pain, swelling and trismus after impacted lower third molar extraction. A randomized, triple blinded, controlled trial. PG - e49-54 AB - OBJECTIVES: The aim of this study is to compare the analgesic and anti-inflammatory effects of the local postoperative administration of a single 12-mg dose of betamethasone after the surgical removal of impacted lower third molars. STUDY DESIGN: A split-mouth, triple-blind, randomized, placebo-controlled clinical trial of 25 patients requiring the surgical removal of symmetrical lower third molars was performed. In the experimental side, a 12-mg dose of betamethasone was administered submucosally after the surgical procedure, while in the control side a placebo (sterile saline solution) was injected in the same area. To assess postoperative pain, visual analogue scales and the consumption of rescue analgesic were used. The facial swelling and trismus were evaluated by measuring facial reference distances and maximum mouth opening. RESULTS: There were no significant differences between the two study groups regarding postoperative pain, facial swelling and trismus. CONCLUSIONS: The injection of a single dose of betamethasone does not seem to reduce pain, facial swelling and trismus after impacted lower third molar removal when compared to placebo. FAU - Marques, José AU - Marques J AD - Facultat d'Odontologia, Universitat de Barcelona, Campus de Bellvitge, Pavelló de Govern 2a planta, Despatx 2.9, 08907 - L'Hospitalet de Llobregat, Spain, rui@ruibf.com. FAU - Pié-Sánchez, Jordi AU - Pié-Sánchez J FAU - Figueiredo, Rui AU - Figueiredo R FAU - Valmaseda-Castellón, Eduard AU - Valmaseda-Castellón E FAU - Gay-Escoda, Cosme AU - Gay-Escoda C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20140101 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents) RN - 9842X06Q6M (Betamethasone) SB - D SB - IM MH - Administration, Topical MH - Analgesics/*administration & dosage MH - Anti-Inflammatory Agents/*administration & dosage MH - Betamethasone/*administration & dosage MH - Double-Blind Method MH - Edema/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus/*prevention & control MH - Young Adult PMC - PMC3909432 COIS- Conflict of interest statement:The authors declare that there are no conflicts of interest in this study. This study was performed by the “Dental and Maxillofacial Pathology and Therapeutic” research group of the IDIBELL Institute. EDAT- 2013/10/15 06:00 MHDA- 2014/12/15 06:00 CRDT- 2013/10/15 06:00 PHST- 2013/04/24 00:00 [received] PHST- 2013/07/24 00:00 [accepted] PHST- 2013/10/15 06:00 [entrez] PHST- 2013/10/15 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] AID - 19280 [pii] AID - 10.4317/medoral.19280 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2014 Jan 1;19(1):e49-54. doi: 10.4317/medoral.19280. PMID- 23535007 OWN - NLM STAT- MEDLINE DCOM- 20140211 LR - 20130603 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 42 IP - 7 DP - 2013 Jul TI - Efficacy of anti-inflammatory drugs in third molar surgery: a randomized clinical trial. PG - 835-42 LID - S0901-5027(13)00101-X [pii] LID - 10.1016/j.ijom.2013.02.017 [doi] AB - This was a double-blind randomized clinical trial to assess the effect of different pharmacological regimens on the level of prostaglandin E2 (PGE2) in urine and saliva, and to correlate the findings to the clinical course after removal of impacted lower third molars. Eighty patients were randomly divided into four groups: group 1 received placebo; group 2 received preoperative ibuprofen, which was continued for a week; group 3 received intraoperative dexamethasone; and group 4 received preoperative ibuprofen, which was continued for a week, in addition to intraoperative dexamethasone. Saliva and urine samples were taken at scheduled intervals. Patients receiving ibuprofen fared significantly better in most parameters. A single dose of dexamethasone alone had a potent but transient beneficial effect when compared to the results with ibuprofen, which showed significant improvement in both subjective and objective parameters. Use of a single dose of intravenous steroids perioperatively helped reduce untoward sequelae, although to a lesser degree and for a shorter duration than continuous ibuprofen. Combining ibuprofen with perioperative dexamethasone added some benefit in some of the measured parameters, but without a statistically significant advantage over using ibuprofen only. CI - Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Mehra, P AU - Mehra P AD - Department of Oral and Maxillofacial Surgery, Boston University School of Dental Medicine and Boston University Medical Center, Boston, MA 02118, USA. pmehra@bu.edu FAU - Reebye, U AU - Reebye U FAU - Nadershah, M AU - Nadershah M FAU - Cottrell, D AU - Cottrell D LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20130325 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents) RN - 7S5I7G3JQL (Dexamethasone) RN - K7Q1JQR04M (Dinoprostone) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents/*therapeutic use MH - Dexamethasone/*administration & dosage MH - Dinoprostone/*analysis MH - Double-Blind Method MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Ibuprofen/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Saliva/chemistry MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Urine/chemistry EDAT- 2013/03/29 06:00 MHDA- 2014/02/12 06:00 CRDT- 2013/03/29 06:00 PHST- 2012/04/30 00:00 [received] PHST- 2013/02/17 00:00 [revised] PHST- 2013/02/21 00:00 [accepted] PHST- 2013/03/29 06:00 [entrez] PHST- 2013/03/29 06:00 [pubmed] PHST- 2014/02/12 06:00 [medline] AID - S0901-5027(13)00101-X [pii] AID - 10.1016/j.ijom.2013.02.017 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2013 Jul;42(7):835-42. doi: 10.1016/j.ijom.2013.02.017. Epub 2013 Mar 25. PMID- 26721012 OWN - NLM STAT- MEDLINE DCOM- 20160202 LR - 20181202 IS - 1025-9589 (Print) IS - 1025-9589 (Linking) VI - 27 IP - 3 DP - 2015 Jul-Sep TI - FREQUENCY OF LINGUAL NERVE INJURY IN MANDIBULAR THIRD MOLAR EXTRACTION: A COMPARISON OF TWO SURGICAL TECHNIQUES. PG - 580-3 AB - BACKGROUND: Surgical removal of impacted mandibular third molar is associated with a number of complications including postoperative bleeding, dry socket, postoperative infection, and injury to regional nerves. Lingual nerve damage is one of the main complications. To prevent this complication different techniques had been used. Lingual flap reflection is one of these procedures in which lingual soft tissue is reflected and retracted deliberately, the nerve is identified and is kept out of the surgical field. The objective of this study was to evaluate a surgical technique for third molar removal which is associated with minimum frequency of lingual nerve damage. METHODS: A randomized controlled trial was performed. A total of 380 patients with impacted mandibular third molars were included in this study. Each patient was allotted randomly by blocked randomization to group A where procedure was performed by reflection and retraction of lingual flap in addition to buccal flap and group B where procedure was performed by retraction of buccal flap only. RESULTS: Lingual nerve damage occurred in 8.94% in Group A in which lingual flap retraction was performed but damage was reversible. In group B, 2.63% lingual nerve damage was observed and nature of damage was permanent. The difference was statistically significant (p=0.008). CONCLUSIONS: Lingual flap retraction poses 3.4 times increased risk of lingual nerve damage during extraction of mandibular third molar when lingual flap is retracted but the nature of damage is reversible. FAU - Shad, Samia AU - Shad S FAU - Shah, Syed Majid Hussain AU - Shah SM FAU - Alamgir AU - Alamgir FAU - Abbasi, Masroor Manshad AU - Abbasi MM LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Pakistan TA - J Ayub Med Coll Abbottabad JT - Journal of Ayub Medical College, Abbottabad : JAMC JID - 8910750 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Incidence MH - Lingual Nerve Injuries/*epidemiology/etiology MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pakistan/epidemiology MH - Tooth Extraction/*adverse effects MH - Young Adult EDAT- 2016/01/02 06:00 MHDA- 2016/02/03 06:00 CRDT- 2016/01/02 06:00 PHST- 2016/01/02 06:00 [entrez] PHST- 2016/01/02 06:00 [pubmed] PHST- 2016/02/03 06:00 [medline] PST - ppublish SO - J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):580-3. PMID- 24338830 OWN - NLM STAT- MEDLINE DCOM- 20140402 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 12 DP - 2013 Dec 12 TI - Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. PG - CD004624 LID - 10.1002/14651858.CD004624.pub2 [doi] AB - BACKGROUND: Both paracetamol and ibuprofen are commonly used analgesics for the relief of pain following the surgical removal of lower wisdom teeth (third molars). In 2010, a novel analgesic (marketed as Nuromol) containing both paracetamol and ibuprofen in the same tablet was launched in the United Kingdom, this drug has shown promising results to date and we have chosen to also compare the combined drug with the single drugs using this model. In this review we investigated the optimal doses of both paracetamol and ibuprofen via comparison of both and via comparison with the novel combined drug. We have taken into account the side effect profile of the study drugs. This review will help oral surgeons to decide on which analgesic to prescribe following wisdom tooth removal. OBJECTIVES: To compare the beneficial and harmful effects of paracetamol, ibuprofen and the novel combination of both in a single tablet for pain relief following the surgical removal of lower wisdom teeth, at different doses and administered postoperatively. SEARCH METHODS: We searched the Cochrane Oral Health Group'sTrials Register (to 20 May 2013); the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 4); MEDLINE via OVID (1946 to 20 May 2013); EMBASE via OVID (1980 to 20 May 2013) and the metaRegister of Controlled Trials (to 20 May 2013). We checked the bibliographies of relevant clinical trials and review articles for further studies. We wrote to authors of the identified randomised controlled trials (RCTs), and searched personal references in an attempt to identify unpublished or ongoing RCTs. No language restriction was applied to the searches of the electronic databases. SELECTION CRITERIA: Only randomised controlled double-blinded clinical trials were included. Cross-over studies were included provided there was a wash out period of at least 14 days. There had to be a direct comparison in the trial of two or more of the trial drugs at any dosage. All trials used the third molar pain model. DATA COLLECTION AND ANALYSIS: All trials identified were scanned independently and in duplicate by two review authors, any disagreements were resolved by discussion, or if necessary a third review author was consulted. The proportion of patients with at least 50% pain relief (based on total pain relief (TOTPAR) and summed pain intensity difference (SPID) data) was calculated for all three drugs at both two and six hours postdosing and meta-analysed for comparison. The proportion of participants using rescue medication over both six and eight hours was also collated and compared. The number of patients experiencing adverse events or the total number of adverse events reported or both were analysed for comparison. MAIN RESULTS: Seven studies were included, they were all parallel-group studies, two studies were assessed as at low risk of bias and three at high risk of bias; two were considered to have unclear bias in their methodology. A total of 2241 participants were enrolled in these trials.Ibuprofen was found to be a superior analgesic to paracetamol at several doses with high quality evidence suggesting that ibuprofen 400 mg is superior to 1000 mg paracetamol based on pain relief (estimated from TOTPAR data) and the use of rescue medication meta-analyses. The risk ratio for at least 50% pain relief (based on TOTPAR) at six hours was 1.47 (95% confidence interval (CI) 1.28 to 1.69; five trials) favouring 400 mg ibuprofen over 1000 mg paracetamol, and the risk ratio for not using rescue medication (also favouring ibuprofen) was 1.50 (95% CI 1.25 to 1.79; four trials).The combined drug showed promising results, with a risk ratio for at least 50% of the maximum pain relief over six hours of 1.77 (95% CI 1.32 to 2.39) (paracetamol 1000 mg and ibuprofen 400 mg) (one trial; moderate quality evidence), and risk ratio not using rescue medication 1.60 (95% CI 1.36 to 1.88) (two trials; moderate quality evidence).The information available regarding adverse events from the studies (including nausea, vomiting, headaches and dizziness) indicated that they were comparable between the treatment groups. However, we could not formally analyse the data as it was not possible to work out how many adverse events there were in total. AUTHORS' CONCLUSIONS: There is high quality evidence that ibuprofen is superior to paracetamol at doses of 200 mg to 512 mg and 600 mg to 1000 mg respectively based on pain relief and use of rescue medication data collected at six hours postoperatively. The majority of this evidence (five out of six trials) compared ibuprofen 400 mg with paracetamol 1000 mg, these are the most frequently prescribed doses in clinical practice. The novel combination drug is showing encouraging results based on the outcomes from two trials when compared to the single drugs. FAU - Bailey, Edmund AU - Bailey E AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Coupland III Building, Oxford Road, Manchester, UK, M13 9PL. FAU - Worthington, Helen V AU - Worthington HV FAU - van Wijk, Arjen AU - van Wijk A FAU - Yates, Julian M AU - Yates JM FAU - Coulthard, Paul AU - Coulthard P FAU - Afzal, Zahid AU - Afzal Z LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20131212 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - IM CIN - Evid Based Dent. 2014 Dec;15(4):106-7. PMID: 25522940 MH - Acetaminophen/*administration & dosage/adverse effects MH - Administration, Oral MH - Analgesics, Non-Narcotic/*administration & dosage/adverse effects MH - Drug Combinations MH - Drug Therapy, Combination/methods MH - Humans MH - Ibuprofen/*administration & dosage/adverse effects MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Randomized Controlled Trials as Topic MH - Salvage Therapy/methods MH - Tooth Extraction/*adverse effects EDAT- 2013/12/18 06:00 MHDA- 2014/04/03 06:00 CRDT- 2013/12/17 06:00 PHST- 2013/12/17 06:00 [entrez] PHST- 2013/12/18 06:00 [pubmed] PHST- 2014/04/03 06:00 [medline] AID - 10.1002/14651858.CD004624.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2013 Dec 12;(12):CD004624. doi: 10.1002/14651858.CD004624.pub2. PMID- 9497628 OWN - NLM STAT- MEDLINE DCOM- 19980416 LR - 20131121 IS - 0070-9484 (Print) IS - 0070-9484 (Linking) VI - 41 IP - 1 DP - 1995 Jan TI - Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions. PG - 961-8 AB - The incidence of post-extraction bleeding and the amount of replacement therapy needed to control bleeding in 24 hemophilic children following the local use of tranexamic acid mouthwash have been investigated. The results of the study showed that 91.6% of patients who used tranexamic acid mouthwash as a supplement to systemic therapy, did not develop post-extraction bleeding; while in 25% of the control patients who received only systemic tranexamic acid, postoperative bleeding was not observed. FAU - Waly, N G AU - Waly NG AD - Pedodontic Dept., Faculty of Oral and Dental Medicine, Cairo University. LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Egypt TA - Egypt Dent J JT - Egyptian dental journal JID - 0373212 RN - 0 (Antifibrinolytic Agents) RN - 0 (Mouthwashes) RN - 0 (cryoprecipitate coagulum) RN - 6T84R30KC1 (Tranexamic Acid) RN - 9001-27-8 (Factor VIII) RN - 9001-32-5 (Fibrinogen) SB - D MH - Administration, Oral MH - Administration, Topical MH - Antifibrinolytic Agents/*administration & dosage MH - Child MH - Child, Preschool MH - Factor VIII/administration & dosage MH - Fibrinogen/administration & dosage MH - Gingival Hemorrhage/epidemiology/etiology/*prevention & control MH - Hemophilia A/*complications/drug therapy MH - Humans MH - Incidence MH - Infusions, Intravenous MH - Mouthwashes MH - Tooth Extraction/*adverse effects MH - Tranexamic Acid/*administration & dosage EDAT- 1995/01/01 00:00 MHDA- 1998/03/14 00:01 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 1998/03/14 00:01 [medline] PHST- 1995/01/01 00:00 [entrez] PST - ppublish SO - Egypt Dent J. 1995 Jan;41(1):961-8. PMID- 21203736 OWN - NLM STAT- MEDLINE DCOM- 20110628 LR - 20110104 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 11 IP - 6 DP - 2010 Dec 1 TI - Analysis of body mass index, the mandible, and dental alveolar arch factors in prediction of mandibular third molar impaction: a pilot study. PG - E041-8 AB - AIM: The aim of this study was to determine how some physical characteristics can be used to predict the occurrence of impacted mandibular third molars. BACKGROUND: While the concept of prophylactic removal of the asymptomatic erupting or impacted mandibular third molar has generated much controversy over the years, new theories of therapeutic surgical removal of the erupting tooth and therapeutic agenesis of the tooth bud are emerging. However, there are a few studies that address the anthropometric factors that could predict an impacted mandibular third molar. METHODS AND MATERIALS: The study included Nigerian patients of both genders who were at least 16 years of age. A total of 83 subjects participated in the study; there were 44 (53 percent) females and 39 (47 percent) males. RESULTS: Eighty-one (97.6 percent) of the participants were between 16 and 23 years old, while 2 (2.4 percent) were between 30 and 39 years old, of which 44 (53 percent) were women and 39 (47 percent) were men. There were 38 (45.8 percent) cases of impaction and 45 (54.2 percent) cases of unimpacted third molar. The mean and standard deviation values of BMI for the two groups in males and females were 21.10±1.90, 22.40±2.70 and 22.00±2.40, 22.30±1.99 respectively, with no significant difference, p>0.05, CI 95%. The two determinant factors of impaction were mandibular length and the difference between alveolar arch length (p=0.04) and total teeth size. Both of these variables had significant inverse correlations with impaction values of p=0.04 and p=0.003, respectively. The prediction values were 59 percent for mandibular length and 81.9 percent for differences between mandibular length and teeth sizes, respectively. The synthesized prediction value by the two determinant factors is 75.6 percent.The subjects were divided into two categories: presence of impaction (Group 1) and absence of impaction (Group 2). Impaction of the mandibular third molar was assessed by clinical and radiographic evaluation. Body mass index (BMI) of each subject was determined by measuring the body weight (BW) and body height (BH), then dividing the weight of the body by the square of the height. The mandibular index (MI) was assessed by measuring the length and width of the mandible (MW). It was calculated by dividing the width of the mandible by the length of the mandible. The mandibular length (ML) consisted of the total teeth sizes of the three anterior teeth, the two premolars, and the first and second molars. These dimensions were measured with a divider/ruler and recorded. The anterior-posterior distance of the arch from the midline to the retromolar pad (alveolar arch length) also was measured. CONCLUSION: The prediction of mandibular third molar impaction was mainly dependent on two factors: the length of the mandible and the difference between arch length and total teeth size. CLINICAL SIGNIFICANCE: Small mandible, small dental arch, and large teeth are risk factors that are strongly associated with the occurrence of impacted third molars. FAU - Akinbami, Babatunde O AU - Akinbami BO AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, College of Health Sciences at the University of Port Harcourt, Port Harcourt, Rivers State, Nigeria. Akinbamzy3@yahoo.com FAU - Didia, Blessing C AU - Didia BC LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20101201 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolar Process/*anatomy & histology MH - Bicuspid/anatomy & histology MH - Body Height/physiology MH - *Body Mass Index MH - Body Weight/physiology MH - Cephalometry MH - Cuspid/anatomy & histology MH - Dental Arch/*anatomy & histology MH - Female MH - Forecasting MH - Humans MH - Incisor/anatomy & histology MH - Male MH - Mandible/*anatomy & histology MH - Molar/anatomy & histology MH - Molar, Third/*pathology MH - Odontometry MH - Pilot Projects MH - Tooth, Impacted/*etiology MH - Young Adult EDAT- 2011/01/05 06:00 MHDA- 2011/06/29 06:00 CRDT- 2011/01/05 06:00 PHST- 2011/01/05 06:00 [entrez] PHST- 2011/01/05 06:00 [pubmed] PHST- 2011/06/29 06:00 [medline] AID - 1526-3711-718 [pii] PST - epublish SO - J Contemp Dent Pract. 2010 Dec 1;11(6):E041-8. PMID- 26680524 OWN - NLM STAT- MEDLINE DCOM- 20160923 LR - 20181113 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 16 IP - 4 DP - 2015 Dec TI - No evidence for stopping long-term aspirin therapy before tooth extraction. PG - 118-9 LID - 10.1038/sj.ebd.6401137 [doi] AB - DATA SOURCES: PubMed, ScienceDirect and EBSCOhost databases. STUDY SELECTION: Prospective randomised controlled trials (RCTs) or controlled trials. DATA EXTRACTION AND SYNTHESIS: Two independent investigators extracted data. The primary measured outcomes were rates of haemorrhage and bleeding time. Disagreements were clarified with a third investigator. Relevant authors were contacted if any relevant data was missing. The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system was used to evaluate the overall quality of evidence. The authors used standardised mean difference or relative risk to evaluate each outcome. RESULTS: Ten studies were included, three randomised controlled trials and seven controlled trials. A total of 1752 patients were enrolled in the meta-analysis; the study group comprised 529 patients on long-term aspirin therapy, and the control group comprised 1223 patients. The risk of post-operative haemorrhage was significantly higher in patients on aspirin therapy (relative risk=2.46; 95% confidence interval: 1.45-4.81) but bleeding time was not significantly different between the two groups (standardised mean difference=0.63; 95% CI: - 0.04 to 1.31). CONCLUSIONS: Increased rates of haemorrhage are observed in patients on long-term aspirin therapy. The authors recommend not stopping long-term aspirin prior to dental extraction, and local measures for haemostasis should be enhanced when required. FAU - Halley, Daphne AU - Halley D AD - Dublin Dental University Hospital, Dublin, Ireland. FAU - Weld-Moore, Robert AU - Weld-Moore R AD - Dublin Dental University Hospital, Dublin, Ireland. FAU - Duane, Brett AU - Duane B AD - Dublin Dental University Hospital, Dublin, Ireland. LA - eng PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Platelet Aggregation Inhibitors) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Aspirin/*adverse effects MH - Evidence-Based Dentistry MH - Hemostasis, Surgical MH - Humans MH - Platelet Aggregation Inhibitors/*adverse effects MH - Postoperative Hemorrhage/*etiology/*prevention & control MH - *Tooth Extraction MH - Withholding Treatment EDAT- 2015/12/19 06:00 MHDA- 2016/09/24 06:00 CRDT- 2015/12/19 06:00 PHST- 2015/12/19 06:00 [entrez] PHST- 2015/12/19 06:00 [pubmed] PHST- 2016/09/24 06:00 [medline] AID - 6401137 [pii] AID - 10.1038/sj.ebd.6401137 [doi] PST - ppublish SO - Evid Based Dent. 2015 Dec;16(4):118-9. doi: 10.1038/sj.ebd.6401137. PMID- 16280233 OWN - NLM STAT- MEDLINE DCOM- 20060518 LR - 20201211 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 35 IP - 4 DP - 2006 Apr TI - Quality of life following lower third molar removal. PG - 343-7 AB - The objective of this study was to evaluate the quality of life (QoL) and degree of satisfaction among adult outpatients after surgical extraction of a lower third molar under local anaesthesia, and to assess the impact of thorough explanation of the anticipated postoperative course on their pain and daily activities. Ninety-two patients filled a questionnaire assessing social isolation, working isolation, eating ability, speaking ability, sleep impairment, physical appearance, discomfort at suture removal and overall satisfaction on days 4 and 7 after surgery. A 100-mm visual analogue scale (VAS) of pain was scored by the patients every day after extraction until day 7. Before extraction, patients were randomly allocated to one of two groups: the test group received detailed verbal instructions from a surgeon about the postoperative course after extraction of the third molars, together with a written text containing postoperative instructions. One day after extraction, they were asked by telephone about their status. The control group only received the written text with postoperative instructions, with a few basic oral explanations. Ninety-one patients (53 of them female) completed the questionnaires. The decrease in pain was linear over time. Men referred significantly less pain than women, but there were no statistically significant differences between the test and control groups. The test group was characterized by a significantly greater inability to work. Lower third molar surgery significantly affects patient quality of life and environment, particularly during the first 3 days after extraction. FAU - Colorado-Bonnin, M AU - Colorado-Bonnin M AD - Master of Oral Surgery and Implantology, School of Dentistry of the University of Barcelona, Barcelona, Spain. FAU - Valmaseda-Castellón, E AU - Valmaseda-Castellón E FAU - Berini-Aytés, L AU - Berini-Aytés L FAU - Gay-Escoda, C AU - Gay-Escoda C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20051108 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative MH - Patient Education as Topic/methods MH - Quality of Life/*psychology MH - Sex Factors MH - Surveys and Questionnaires MH - Tooth Extraction/*psychology EDAT- 2005/11/11 09:00 MHDA- 2006/05/19 09:00 CRDT- 2005/11/11 09:00 PHST- 2004/09/26 00:00 [received] PHST- 2005/08/03 00:00 [revised] PHST- 2005/08/26 00:00 [accepted] PHST- 2005/11/11 09:00 [pubmed] PHST- 2006/05/19 09:00 [medline] PHST- 2005/11/11 09:00 [entrez] AID - S0901-5027(05)00307-3 [pii] AID - 10.1016/j.ijom.2005.08.008 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2006 Apr;35(4):343-7. doi: 10.1016/j.ijom.2005.08.008. Epub 2005 Nov 8. PMID- 23108628 OWN - NLM STAT- MEDLINE DCOM- 20150907 LR - 20181113 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 17 IP - 7 DP - 2013 Sep TI - Beneficial effect of methylprednisolone after mandibular third molar surgery: a randomized, double-blind, placebo-controlled split-mouth trial. PG - 1693-700 LID - 10.1007/s00784-012-0867-1 [doi] AB - OBJECTIVES: Third molar (M3) removal is the model most frequently used for pain trials in oral surgery. Corticosteroids are frequently administered to reduce trismus and swelling after dentoalveolar surgical procedures. The purpose of this investigation was to evaluate the influence of a single, preoperative oral application of methylprednisolone on postoperative trismus, pain intensity, and the subjective need for analgesic medication after surgical removal of impacted mandibular M3 (LM3). MATERIALS AND METHODS: Sixteen healthy patients requiring similar bilateral surgical LM3 removal were included in a prospective, randomized, placebo-controlled, double-blind study in a split-mouth design. At random, each patient received either weight-dependent methylprednisolone (40-80 mg) or a placebo orally 1 h prior to surgery. In each case, the right and left LM3 were treated in independent visits. Trismus, swelling, pain measured on a 100-mm visual analog scale, and the postoperative demand of analgesics were assessed. RESULTS: Statistical analysis indicates a significant reduction of trismus, swelling, pain intensity, and patient-controlled intake of analgesics during the whole postsurgical period of investigation (first to seventh day). CONCLUSIONS: The results of this study suggest that a single preoperative weight-dependent administration of methylprednisolone is a safe and effective concept for diminishing postoperative discomfort, pain intensity, and the total intake of analgesics after wisdom tooth extractions. CLINICAL RELEVANCE: In case of missing contraindications, the preoperative administration of methylprednisolone is recommended, a routine medication for more extended procedures in oral surgery. FAU - Acham, Stephan AU - Acham S AD - Department of Oral Surgery and Radiology, University Dental Clinic, Medical University Graz, A-8036, Graz, Austria. stephan.acham@medunigraz.at FAU - Klampfl, Arnold AU - Klampfl A FAU - Truschnegg, Astrid AU - Truschnegg A FAU - Kirmeier, Robert AU - Kirmeier R FAU - Sandner-Kiesling, Andreas AU - Sandner-Kiesling A FAU - Jakse, Norbert AU - Jakse N LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20121030 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Placebos) RN - X4W7ZR7023 (Methylprednisolone) SB - D MH - Adult MH - Anti-Inflammatory Agents/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mandible/diagnostic imaging/surgery MH - Methylprednisolone/*therapeutic use MH - Molar, Third/diagnostic imaging/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Placebos MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - Radiography, Panoramic MH - Treatment Outcome MH - Trismus/prevention & control EDAT- 2012/10/31 06:00 MHDA- 2015/09/08 06:00 CRDT- 2012/10/31 06:00 PHST- 2012/07/25 00:00 [received] PHST- 2012/10/17 00:00 [accepted] PHST- 2012/10/31 06:00 [entrez] PHST- 2012/10/31 06:00 [pubmed] PHST- 2015/09/08 06:00 [medline] AID - 10.1007/s00784-012-0867-1 [doi] PST - ppublish SO - Clin Oral Investig. 2013 Sep;17(7):1693-700. doi: 10.1007/s00784-012-0867-1. Epub 2012 Oct 30. PMID- 33247572 OWN - NLM STAT- MEDLINE DCOM- 20210302 LR - 20210325 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 26 IP - 2 DP - 2021 Mar 1 TI - Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. PG - e141-e150 LID - 10.4317/medoral.24088 [doi] AB - BACKGROUND: The preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. MATERIAL AND METHODS: The researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. RESULTS: Fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). CONCLUSIONS: The clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine's. FAU - Martins-de-Barros, A-V AU - Martins-de-Barros AV AD - Hospital Universitário Oswaldo Cruz University of Pernambuco, Campus Santo Amaro Rua Arnóbio Marquês, 310 Santo Amaro, Recife, Pernambuco, Brazil allanmartinsodonto@gmail.com. FAU - Barros, A-M AU - Barros AM FAU - Siqueira, A-K AU - Siqueira AK FAU - Lucena, E-E AU - Lucena EE FAU - Sette de Souza, P-H AU - Sette de Souza PH FAU - Araújo, F-A AU - Araújo FA LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20210301 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 7S5I7G3JQL (Dexamethasone) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Dexamethasone/therapeutic use MH - Double-Blind Method MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - *Ketorolac MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/prevention & control MH - Tooth Extraction/adverse effects MH - *Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control PMC - PMC7980286 COIS- Conflicts of interest The authors have no conflict of interest to declare. EDAT- 2020/11/29 06:00 MHDA- 2021/03/03 06:00 CRDT- 2020/11/28 08:32 PHST- 2020/06/14 00:00 [received] PHST- 2020/10/08 00:00 [accepted] PHST- 2020/11/29 06:00 [pubmed] PHST- 2021/03/03 06:00 [medline] PHST- 2020/11/28 08:32 [entrez] AID - 24088 [pii] AID - 10.4317/medoral.24088 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2021 Mar 1;26(2):e141-e150. doi: 10.4317/medoral.24088. PMID- 25528251 OWN - NLM STAT- MEDLINE DCOM- 20161223 LR - 20181113 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 19 IP - 2 DP - 2015 Jun TI - Postoperative hemostatic efficacy of gauze soaked in tranexamic acid, fibrin sponge, and dry gauze compression following dental extractions in anticoagulated patients with cardiovascular disease: a prospective, randomized study. PG - 209-16 LID - 10.1007/s10006-014-0479-9 [doi] AB - INTRODUCTION: Oral anticoagulants are widely prescribed drugs. Interruption of anticoagulant therapy prior to oral surgery has been an issue of great controversy. The purpose of this study was to evaluate the incidence of bleeding complications after dental extractions in patients on anticoagulant therapy (warfarin) in whom different local hemostatic methods were used. MATERIAL AND METHODS: Patients using warfarin and requiring extractions of at least two teeth were screened to participate in this prospective, randomized study. Extraction sites were considered as sampling units (statistically representative sample size) and were allocated to one of the three study groups (G1-4.8% tranexamic acid; G2-fibrin sponge; and G3-no local hemostatic agents). RESULTS: Eighty-four extraction sites were obtained from patients with mitral valve prolapse (47.4%), prosthetic cardiac valve (23.7%), venous thromboembolism (21.1%), and pulmonary embolism (5.2%). International normalized ratio (INR) values ranged between 2.1 and 3.1 (mean 2.51 ± 0.1). Postoperative bleeding was observed in four surgical sites (p < 0.001) and was mainly in older patients (p = 0.005). DISCUSSION: The three local hemostatic protocols were similarly effective in controlling postoperative bleeding in patients undergoing anticoagulant therapy with warfarin. The majority of teeth could be extracted with minimal problems in patients with cardiovascular diseases receiving treatment with anticoagulant therapy. FAU - Soares, Eduardo Costa Studart AU - Soares EC AD - Division of Oral and Maxillofacial Surgery, Department of Clinical Dentistry, School of Dentistry, Federal University of Ceará, Rua Cap. Francisco Pedro S/N, Rodolfo Teófilo, Fortaleza, CE, 60430-170, Brazil. FAU - Costa, Fábio Wildson Gurgel AU - Costa FW FAU - Bezerra, Tácio Pinheiro AU - Bezerra TP FAU - Nogueira, Carlos Bruno Pinheiro AU - Nogueira CB FAU - de Barros Silva, Paulo Goberlânio AU - de Barros Silva PG FAU - Batista, Saulo Hilton Botelho AU - Batista SH FAU - Sousa, Fabrício Bitu AU - Sousa FB FAU - Sá Roriz Fonteles, Cristiane AU - Sá Roriz Fonteles C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20141221 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Anticoagulants) RN - 0 (Fibrin Tissue Adhesive) RN - 5Q7ZVV76EI (Warfarin) RN - 6T84R30KC1 (Tranexamic Acid) SB - D SB - IM MH - Administration, Topical MH - Adult MH - Aged MH - Anticoagulants/*adverse effects/therapeutic use MH - Brazil MH - Cardiovascular Diseases/*complications/*drug therapy MH - Female MH - Fibrin Tissue Adhesive/*administration & dosage MH - Hemostatic Techniques MH - Humans MH - Male MH - Middle Aged MH - Postoperative Hemorrhage/*chemically induced/*therapy MH - Pressure MH - Prospective Studies MH - *Surgical Sponges MH - *Tooth Extraction MH - Tranexamic Acid/*administration & dosage MH - Warfarin/*adverse effects/therapeutic use EDAT- 2014/12/22 06:00 MHDA- 2016/12/24 06:00 CRDT- 2014/12/22 06:00 PHST- 2014/01/24 00:00 [received] PHST- 2014/12/08 00:00 [accepted] PHST- 2014/12/22 06:00 [entrez] PHST- 2014/12/22 06:00 [pubmed] PHST- 2016/12/24 06:00 [medline] AID - 10.1007/s10006-014-0479-9 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2015 Jun;19(2):209-16. doi: 10.1007/s10006-014-0479-9. Epub 2014 Dec 21. PMID- 26471464 OWN - NLM STAT- MEDLINE DCOM- 20160711 LR - 20181202 IS - 1473-4877 (Electronic) IS - 0300-7995 (Linking) VI - 31 IP - 12 DP - 2015 Dec TI - Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. PG - 2179-83 LID - 10.1185/03007995.2015.1108909 [doi] AB - INTRODUCTION: Reducing post-interventional inflammation and pain in odontostomatological surgery procedures, such as tooth extractions, implants or oral biopsies is a relevant clinical goal. Chlorhexidine oral rinse is commonly used with this aim. Recently a new product containing chlorhexidine, dexpanthenol, allantoin and chitosan (Bexident Post [BP]) in a gel formulation has been developed. We evaluated the efficacy of BP in controlling postsurgical inflammation and pain and in promoting cicatrization in subjects undergoing molar extractions. SUBJECTS AND METHODS: We conducted a prospective sequential cross-over, randomized controlled study in patients undergoing surgical removal of at least two impacted mandibular third molars (teeth numbers 38 and 48) (numbers 17 and 32 in the Universal Tooth Numbering System), in two separate sessions, to determine the effect of BP in comparison with bicarbonate (BC) oral rinse (one spoonful in 200 ml of water), both used three times daily. Each subject utilized both products in a randomized sequential manner after each tooth extraction. Primary outcomes of the study were post-procedure pain and inflammation. Secondary outcomes were analgesic pill rescue use (metamizole 1 cap every 8 hours if needed) and an assessor-blinded evaluation of cicatrization with a semi-quantitative scale (good, satisfactory and insufficient). Post-procedure pain was assessed 6 hours after tooth extraction and for seven consecutive days by means of a 10 cm visual analogue scale (VAS) (from 0: no pain to 10: extreme pain). The extent of inflammation was evaluated through metric measurements of facial perimeter using standardized anatomical reference points. RESULTS: A total of 47 patients (22 men and 25 women; mean age 34 years) were enrolled with a total of 94 molars extracted. Nineteen subjects applied BC as the first sequential treatment and 28 BP as the first. Before surgery no mean differences in the two treatments in inflammation measurements were observed. After surgery mean VAS pain score was similar between the two treatments in the first 6 hours (VAS score = 6.5). A marked progressive reduction in pain intensity with the use of BP was observed throughout the treatment period in comparison with BC (7 day mean scores 3.7 vs. 5.3; p = 0.0001). BP was superior to BC in reducing inflammation with -50% of the inflammation-related measurement (6 mm vs. 12 mm; p = 0.0001). Analgesic pill consumption was lower with BP in comparison with BC (13 pills vs. 24; p < 0.05). Cicatrization was scored 'good' in a higher percentage of subjects during BP use (64%) in comparison with the BC group (13%) (p = 0.0001). No serious side effects were reported with either treatment regimen. CONCLUSION: In this trial BP performed better than BC in controlling pain and inflammation in subjects undergoing dental surgery, reducing the consumption of analgesics and favoring better cicatrization. FAU - Lopez-Lopez, Jose AU - Lopez-Lopez J FAU - Jan-Pallí, Enric AU - Jan-Pallí E AD - a a Department of Odontostomatology , University of Barcelona and Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, L'Hospitalet de Llobregat , Barcelona , Spain. FAU - lez-Navarro, Beatriz Gonzá AU - lez-Navarro BG FAU - Jané-Salas, Enric AU - Jané-Salas E AD - a a Department of Odontostomatology , University of Barcelona and Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, L'Hospitalet de Llobregat , Barcelona , Spain. FAU - Estrugo-Devesa, Albert AU - Estrugo-Devesa A AD - a a Department of Odontostomatology , University of Barcelona and Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, L'Hospitalet de Llobregat , Barcelona , Spain. FAU - Milani, Massimo AU - Milani M AD - b b Medical Department , Isdin Barcelona , Spain. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20151104 PL - England TA - Curr Med Res Opin JT - Current medical research and opinion JID - 0351014 RN - 0 (Analgesics) RN - 0 (Bicarbonates) RN - 19F5HK2737 (Pantothenic Acid) RN - 1O6C93RI7Z (dexpanthenol) RN - 344S277G0Z (Allantoin) RN - 9012-76-4 (Chitosan) RN - R4KO0DY52L (Chlorhexidine) SB - IM CIN - Curr Med Res Opin. 2015 Dec;31(12):2185-7. PMID: 26471741 EIN - Curr Med Res Opin. 2016;32(2):395. Lope-Lopez, Jose [corrected to Lopez-Lopez, Jose]; González-Navarro, Beatriz [corrected to lez-Navarro, Beatriz Gonzá]. PMID: 26691179 MH - Adult MH - Allantoin/administration & dosage MH - Analgesics/therapeutic use MH - Bicarbonates/administration & dosage MH - Chitosan/administration & dosage MH - Chlorhexidine/administration & dosage MH - Cicatrix/*prevention & control MH - Cross-Over Studies MH - Female MH - Humans MH - Inflammation/*drug therapy MH - Male MH - Middle Aged MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Pantothenic Acid/administration & dosage/analogs & derivatives MH - Prospective Studies MH - Tooth Extraction/*methods MH - Young Adult OTO - NOTNLM OT - Chitosan OT - Chlorhexidine OT - Controlled clinical trial OT - Dexpanthenol OT - Oral rinse OT - Oral surgery EDAT- 2015/10/17 06:00 MHDA- 2016/07/12 06:00 CRDT- 2015/10/17 06:00 PHST- 2015/10/17 06:00 [entrez] PHST- 2015/10/17 06:00 [pubmed] PHST- 2016/07/12 06:00 [medline] AID - 10.1185/03007995.2015.1108909 [doi] PST - ppublish SO - Curr Med Res Opin. 2015 Dec;31(12):2179-83. doi: 10.1185/03007995.2015.1108909. Epub 2015 Nov 4. PMID- 15106245 OWN - NLM STAT- MEDLINE DCOM- 20040817 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 2 DP - 2004 TI - Tissue adhesives for closure of surgical incisions. PG - CD004287 AB - BACKGROUND: Sutures, staples and adhesive tapes are the traditional methods of wound closure, whilst tissue adhesives have entered clinical practice more recently. Closure of wounds with sutures enables meticulous closure, but sutures may induce tissue reactivity and they usually require removal. Tissue adhesives offer the advantages there are no sutures to remove later for the patient and no risk of needlestick injury to the surgeon. Tissue adhesives have been used primarily in emergency rooms but this review looks at the use of tissue adhesives in the operating room where surgeons are increasingly using these for the closure of surgical skin incisions. OBJECTIVES: To determine the relative effects of various tissue adhesives and conventional skin closure techniques on the healing of surgical wounds. SEARCH STRATEGY: The Cochrane Wounds Group Specialised Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched. Bibliographies of review articles were checked for studies outside the handsearched journals and wound care product manufacturers were contacted. SELECTION CRITERIA: Randomised controlled clinical trials only. DATA COLLECTION AND ANALYSIS: Screening of eligible studies and data extraction was conducted independently and in triplicate whilst assessment of the methodological quality of the trials was conducted independently and in duplicate. Results were expressed as random effect models using weighted mean differences for continuous outcomes and relative risk with 95% confidence intervals for dichotomous outcomes. Heterogeneity was investigated including both clinical and methodological factors. MAIN RESULTS: Eight RCTs were included (630 patients). No statistically significant differences were found between various tissue adhesives and sutures (8 trials) for dehiscence, infection, satisfaction with cosmetic appearance when assessed by patients' or surgeons' general satisfaction. Nor were differences found between a tissue adhesive and tapes (2 trials) for infection, patients' assessment of cosmetic appearance, patient satisfaction or surgeon satisfaction. However a statistically significant difference was found for surgeons' assessment of cosmetic appearance with mean difference 13 (95%CI 5 to 21), the higher mean rating for the tissue adhesive group. REVIEWERS' CONCLUSIONS: Surgeons may consider the use of tissue adhesives as an alternative to sutures or adhesive tape for the closure of incisions in the operating room. There is a need for trials in all areas but in particular to include patients that require incision closure in areas of high tension and patients of general health that may impair wound healing. FAU - Coulthard, P AU - Coulthard P AD - Oral and Maxillofacial Surgery, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester, UK, M15 6FH. FAU - Worthington, H AU - Worthington H FAU - Esposito, M AU - Esposito M FAU - Elst, M AU - Elst M FAU - Waes, O J F AU - Waes OJ LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Cyanoacrylates) RN - 0 (Tissue Adhesives) RN - 0 (octylcyanoacrylate) RN - F8CEP82QNP (Enbucrilate) SB - IM UIN - Cochrane Database Syst Rev. 2010;(5):CD004287. PMID: 20464728 MH - Bandages MH - Cyanoacrylates MH - Enbucrilate MH - Humans MH - Randomized Controlled Trials as Topic MH - *Surgical Procedures, Operative MH - Surgical Wound Dehiscence MH - Surgical Wound Infection/diagnosis MH - Sutures MH - *Tissue Adhesives MH - *Wound Healing RF - 30 EDAT- 2004/04/24 05:00 MHDA- 2004/08/18 05:00 CRDT- 2004/04/24 05:00 PHST- 2004/04/24 05:00 [pubmed] PHST- 2004/08/18 05:00 [medline] PHST- 2004/04/24 05:00 [entrez] AID - 10.1002/14651858.CD004287.pub2 [doi] PST - ppublish SO - Cochrane Database Syst Rev. 2004;(2):CD004287. doi: 10.1002/14651858.CD004287.pub2. PMID- 10994324 OWN - NLM STAT- MEDLINE DCOM- 20001115 LR - 20170225 IS - 1432-9417 (Print) IS - 1432-9417 (Linking) VI - 4 IP - 4 DP - 2000 Jul TI - [Hemostatic wound management in marcumar patients. Collagen fleece vs. tranexamic acid]. PG - 240-4 AB - A total of 124 patients on oral anticoagulation therapy with coumarin were treated by orosurgical procedures and entered into a study to determine the hemostatic efficiency of different methods. The therapeutic anticoagulation level was determined in accordance with the recommendations of the American Heart Association (low risk: 2.0 < INR < 3.0; high risk: 2.5 < INR < 3.5) and maintained during treatment. In one group, the alveoli were treated with collagen, in a second group a mouthrinse regime with tranexamic acid was implemented. Twenty-three patients had to be excluded because anticoagulation levels differed from the recommended values. The group treated with collagen included 31 patients, the group with tranexamic acid mouthwashes, 32 patients. A third group was analyzed in which a controlled change in the anticoagulation level had been performed and all treated alveoli had been covered by mucosal flaps (n = 38); they were compared to the other two groups. The surgical proceedings were outlined precisely. Patients treated with collagen had a bleeding rate of 19%, patients with tranexamic acid mouthwash 6%, and those treated with mucosal flaps 40%. The data were not suited for statistical evaluation, they were objected to a descriptive analysis: the confidence intervals were determined by tables for binomial distributions. These did confirm the difference in the frequency of bleeding for the tranexamic acid and mucosal flap groups. FAU - Bublitz, R AU - Bublitz R AD - Klinik für Kiefer- und Gesichtschirurgie, Plastische Operationen, Katharinenhospital, Klinikum Stuttgart, Deutschland. FAU - Sommer, S AU - Sommer S FAU - Weingart, D AU - Weingart D FAU - Bäuerle, K AU - Bäuerle K FAU - Both, A AU - Both A LA - ger PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - English Abstract PT - Journal Article TT - Hämostyptische Wundversorgung bei Marcumarpatienten. Kollagenvlies vs. Tranexamsäure. PL - Germany TA - Mund Kiefer Gesichtschir JT - Mund-, Kiefer- und Gesichtschirurgie : MKG JID - 9716576 RN - 0 (Anticoagulants) RN - 0 (Hemostatics) RN - 6T84R30KC1 (Tranexamic Acid) RN - 9007-34-5 (Collagen) RN - Q08SIO485D (Phenprocoumon) SB - D SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Alveolar Process/*surgery MH - Anticoagulants/*adverse effects MH - Collagen/*administration & dosage MH - *Hemostasis, Surgical MH - Hemostatics/*administration & dosage MH - Humans MH - Middle Aged MH - Phenprocoumon/*adverse effects MH - Postoperative Hemorrhage/drug therapy MH - *Tooth Extraction MH - Tranexamic Acid/*administration & dosage MH - Treatment Outcome EDAT- 2000/09/20 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/09/20 11:00 PHST- 2000/09/20 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/09/20 11:00 [entrez] AID - 10.1007/s100060000155 [doi] PST - ppublish SO - Mund Kiefer Gesichtschir. 2000 Jul;4(4):240-4. doi: 10.1007/s100060000155. PMID- 23115765 OWN - NLM STAT- MEDLINE DCOM- 20131126 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 43 IP - 10 DP - 2012 Nov-Dec TI - Clinical study on the closure of extraction wounds of partially soft tissue-impacted mandibular third molars. PG - 863-70 AB - OBJECTIVE: When a mandibular third molar is partially impacted in the soft tissue, it must be determined whether the extraction wound should be left partially open or completely closed. We hypothesize that a blood clot preserving a surgical wound with easily cleanable surfaces by primary closure and drain application would postoperatively minimize dry socket and/or alveolitis development. METHOD AND MATERIALS: Twenty patients requiring bilateral extraction of partially soft tissue-impacted mandibular third molars in a vertical position were included in the study. The existence of dry sockets, alveolitis, pain, facial swelling, and trismus were evaluated on the second, fifth, and seventh days of the postoperative period. RESULTS: On the second day, pain, trismus, and swelling were higher in the drained group; however, pain reduced progressively in the drained group over time. There were no cases of dry sockets or alveolitis except for a single patient on the seventh day in the drained group over the 7-day study period. On the other hand, in the secondary closure group, the number of dry sockets was 8 (40%) on the second day. The number of alveolitis was 10 (50%) on the fifth day and 4 (20%) on the seventh day. CONCLUSION: Closed healing by drain insertion after removal of partially soft tissue-impacted third molars produces less frequent postoperative dry sockets and/or alveolitis development than occurs with open healing of the surgical wound. In cases with a risk of alveolitis development (lack of oral hygiene, immunocompromised patients, etc), it can be avoided with the "kiddle effect" and related undesired complications by implementing closed healing with drain insertion. FAU - Aydintug, Yavuz Sinan AU - Aydintug YS AD - Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara, Turkey. FAU - Bayar, Gürkan Raşit AU - Bayar GR FAU - Gulses, Aydin AU - Gulses A FAU - Misir, Ahmet Ferhat AU - Misir AF FAU - Ogretir, Ozlem AU - Ogretir O FAU - Dogan, Necdet AU - Dogan N FAU - Sencimen, Metin AU - Sencimen M FAU - Acikel, Cengiz Han AU - Acikel CH LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Adult MH - Cross-Over Studies MH - Drainage/*methods MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - *Suture Techniques MH - Tooth Extraction/*methods MH - Tooth Socket/*surgery MH - Tooth, Impacted/*surgery MH - Wound Healing MH - Young Adult EDAT- 2012/11/02 06:00 MHDA- 2013/12/16 06:00 CRDT- 2012/11/02 06:00 PHST- 2012/11/02 06:00 [entrez] PHST- 2012/11/02 06:00 [pubmed] PHST- 2013/12/16 06:00 [medline] AID - 840579 [pii] PST - ppublish SO - Quintessence Int. 2012 Nov-Dec;43(10):863-70. PMID- 24521173 OWN - NLM STAT- MEDLINE DCOM- 20150820 LR - 20140422 IS - 1600-0579 (Electronic) IS - 1396-5883 (Linking) VI - 18 IP - 2 DP - 2014 May TI - A computerised third molar surgery simulator--results of supervision by different professionals. PG - 86-90 LID - 10.1111/eje.12060 [doi] AB - The purpose of the study was to investigate which supervisory approach afforded the most efficient learning method for undergraduate students in oral and maxillofacial surgery (OMS) using a computerised third molar surgery simulator. Fifth year dental students participated voluntarily in a randomised experimental study using the simulator. The amount of time required and the number of trials used by each student were evaluated as a measure of skills development. Students had the opportunity to practise the procedure until no further visible improvements were achieved. The study assessed four different types of supervision to guide the students. The first group was where they were supported by a teacher/specialist in OMS, the second by a teaching assistant, the third group practised without any supervision and the fourth received help from a simulator technician/engineer. A protocol describing assessment criteria was designed for this purpose, and a questionnaire was completed by all participating students after the study. The average number of attempts required to virtually remove a third molar tooth in the simulator was 1.44 times for the group supervised by an OMS teacher; 1.5 times for those supervised by a teaching assistant; 2.8 times for those who had no supervision; and 3.6 times when support was provided only by a simulator technician. The results showed that the most efficient experience of the students was when they were helped by an OMS teacher or a teaching assistant. In a time and cost-effective perspective, supervision by a teaching assistant for a third molar surgery simulator would be the optimal choice. CI - © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Rosen, A AU - Rosen A AD - Division of Oral and Maxillofacial Surgery, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden; Division of Oral and Maxillofacial Surgery, Department of Clinical Dentistry, University of Bergen, Bergen, Norway. FAU - Eliassi, S AU - Eliassi S FAU - Fors, U AU - Fors U FAU - Sallnäs, E-L AU - Sallnäs EL FAU - Forsslund, J AU - Forsslund J FAU - Sejersen, R AU - Sejersen R FAU - Lund, B AU - Lund B LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20130701 PL - England TA - Eur J Dent Educ JT - European journal of dental education : official journal of the Association for Dental Education in Europe JID - 9712132 SB - D MH - Adult MH - *Clinical Competence MH - Education, Dental/*methods MH - Educational Measurement MH - Female MH - Humans MH - Male MH - *Manikins MH - Molar, Third/*surgery MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - learning OT - supervision OT - teaching methods OT - third molar surgery simulator EDAT- 2014/02/14 06:00 MHDA- 2015/08/21 06:00 CRDT- 2014/02/14 06:00 PHST- 2013/06/03 00:00 [accepted] PHST- 2014/02/14 06:00 [entrez] PHST- 2014/02/14 06:00 [pubmed] PHST- 2015/08/21 06:00 [medline] AID - 10.1111/eje.12060 [doi] PST - ppublish SO - Eur J Dent Educ. 2014 May;18(2):86-90. doi: 10.1111/eje.12060. Epub 2013 Jul 1. PMID- 27475688 OWN - NLM STAT- MEDLINE DCOM- 20180416 LR - 20190609 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 21 IP - 5 DP - 2016 Sep 1 TI - Comparison of the analgesic efficacy of oral ketorolac versus intramuscular tramadol after third molar surgery: A parallel, double-blind, randomized, placebo-controlled clinical trial. PG - e637-43 AB - BACKGROUND: Preemptive analgesia is considered an alternative for treating the postsurgical pain of third molar removal. The aim of this study was to evaluate the preemptive analgesic efficacy of oral ketorolac versus intramuscular tramadol after a mandibular third molar surgery. MATERIAL AND METHODS: A parallel, double-blind, randomized, placebo-controlled clinical trial was carried out. Thirty patients were randomized into two treatment groups using a series of random numbers: Group A, oral ketorolac 10 mg plus intramuscular placebo (1 mL saline solution); or Group B, oral placebo (similar tablet to oral ketorolac) plus intramuscular tramadol 50 mg diluted in 1 mL saline solution. These treatments were given 30 min before the surgery. We evaluated the time of first analgesic rescue medication, pain intensity, total analgesic consumption and adverse effects. RESULTS: Patients taking oral ketorolac had longer time of analgesic covering and less postoperative pain when compared with patients receiving intramuscular tramadol. CONCLUSIONS: According to the VAS and UAC results, this study suggests that 10 mg of oral ketorolac had superior analgesic effect than 50 mg of tramadol when administered before a mandibular third molar surgery. FAU - Isiordia-Espinoza, M-A AU - Isiordia-Espinoza MA AD - Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava #2, Zona Universitaria, C.P. 78290, San Luis Potosí, S.L.P. México, apozos@uaslp.mx. FAU - Pozos-Guillen, A AU - Pozos-Guillen A FAU - Martinez-Rider, R AU - Martinez-Rider R FAU - Perez-Urizar, J AU - Perez-Urizar J LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160901 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Analgesics) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 39J1LGJ30J (Tramadol) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Analgesics MH - Analgesics, Opioid/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Double-Blind Method MH - Humans MH - Ketorolac/*therapeutic use MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative MH - Tooth, Impacted/*surgery MH - Tramadol/*therapeutic use PMC - PMC5005104 COIS- The authors have declared that no conflict of interest exist. EDAT- 2016/08/01 06:00 MHDA- 2018/04/17 06:00 CRDT- 2016/08/01 06:00 PHST- 2015/09/30 00:00 [received] PHST- 2016/04/30 00:00 [accepted] PHST- 2016/08/01 06:00 [entrez] PHST- 2016/08/01 06:00 [pubmed] PHST- 2018/04/17 06:00 [medline] AID - 21077 [pii] AID - 10.4317/medoral.21077 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2016 Sep 1;21(5):e637-43. doi: 10.4317/medoral.21077. PMID- 16202020 OWN - NLM STAT- MEDLINE DCOM- 20051201 LR - 20151119 IS - 0909-8836 (Print) IS - 0909-8836 (Linking) VI - 113 IP - 5 DP - 2005 Oct TI - Effectiveness of clinical practice guideline implementation on lower third molar management in improving clinical decision-making: a randomized controlled trial. PG - 349-54 AB - The objective of this study was twofold, namely to evaluate the effectiveness of a dental clinical practice guideline on the management of asymptomatic impacted lower third molars (i) on referral rates and (ii) on dentists' change in knowledge. A two-arm cluster randomized controlled trial, with pre- and post-test assessments, was conducted. A guideline was implemented by multifaceted interventions (i.e. feedback, reminders, and an interactive meeting). The effect was evaluated after 1 yr by repeating the baseline questionnaire and by monitoring the number of patients who were referred for removal of their asymptomatic impacted mandibular third molars. Instruments were questionnaires for detecting changes in knowledge, patient records, and panoramic radiographs. The knowledge of dentists regarding asymptomatic mandibular third molar management was found to increase significantly in the intervention group as compared to the control group. There was no statistically significant difference between the groups in guideline-consistent patient referral rates at the post-test assessment. It was concluded that the methodology employed for dissemination and implementation of a clinical practice guideline on asymptomatic mandibular third molar management improves dentists' knowledge on this topic and is effective in improving decision-making in simulated cases; however, no clinical effect was demonstrated. FAU - van der Sanden, Wil J M AU - van der Sanden WJ AD - Department of Preventive and Restorative Dentistry, College of Dental Science, Nijmegen, the Netherlands. w.vandersanden@dent.umcn.nl FAU - Mettes, Dirk G AU - Mettes DG FAU - Plasschaert, Alphons J M AU - Plasschaert AJ FAU - Grol, Richard P T M AU - Grol RP FAU - Mulder, Jan AU - Mulder J FAU - Verdonschot, Emiel H AU - Verdonschot EH LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Eur J Oral Sci JT - European journal of oral sciences JID - 9504563 SB - D SB - IM CIN - Evid Based Dent. 2006;7(1):8. PMID: 16557246 MH - Communication MH - *Decision Making MH - Dental Records MH - Education, Dental, Continuing MH - False Negative Reactions MH - False Positive Reactions MH - Feedback MH - Female MH - Follow-Up Studies MH - General Practice, Dental/education MH - *Guideline Adherence MH - Humans MH - Male MH - Mandible MH - Molar, Third/*pathology/surgery MH - *Practice Guidelines as Topic MH - Radiography, Panoramic MH - Referral and Consultation MH - Surveys and Questionnaires MH - Tooth Extraction MH - Tooth, Impacted/surgery/*therapy EDAT- 2005/10/06 09:00 MHDA- 2005/12/13 09:00 CRDT- 2005/10/06 09:00 PHST- 2005/10/06 09:00 [pubmed] PHST- 2005/12/13 09:00 [medline] PHST- 2005/10/06 09:00 [entrez] AID - EOS232 [pii] AID - 10.1111/j.1600-0722.2005.00232.x [doi] PST - ppublish SO - Eur J Oral Sci. 2005 Oct;113(5):349-54. doi: 10.1111/j.1600-0722.2005.00232.x. PMID- 26922634 OWN - NLM STAT- MEDLINE DCOM- 20180109 LR - 20181113 IS - 1436-3771 (Electronic) IS - 1432-6981 (Print) IS - 1432-6981 (Linking) VI - 21 IP - 1 DP - 2017 Jan TI - Postoperative socket irrigation with drinking tap water reduces the risk of inflammatory complications following surgical removal of third molars: a multicenter randomized trial. PG - 71-83 LID - 10.1007/s00784-016-1751-1 [doi] AB - OBJECTIVES: The primary aim of the present study was to evaluate the effectiveness of postoperative irrigation of the socket with drinking tap water on inflammatory complications following lower third molar removal. MATERIAL AND METHODS: A multicenter randomized controlled trial was carried out from June 2013 to June 2014. In one arm of the study, patients were instructed to irrigate the tooth socket and surgical site with a Monoject® Curved 412 Tip Syringe (Tyco/healthcare-Kendall, Mansfield, MA, USA) with tap water. In a second arm of the study, the standard postoperative instructions did not include irrigation instructions. The incidences of alveolar osteitis and wound infection were recorded for each group and analyzed by the Fisher's exact test. RESULTS: A total of 280 patients with 333 mandibular third molars were analyzed. According to the intention-to-treat (ITT) analysis, inflammatory complications occurred in 18 cases in the Monoject® group (11.4 %) compared to 34 cases (19.1 %) in the control group (p = 0.04). These complications were associated with significant worse outcomes regarding quality of life, pain, and trismus and caused significantly more missed days of work or study. Female gender, age >26, bone removal, deep impacted third molars, less experienced surgeons, and a high amount of debris at the surgical site were also identified as risk factors for developing inflammatory complications following lower third molar removal. CONCLUSION: Irrigation of the surgical site with drinking tap water using a curved syringe following removal of third molars is effective in reducing the risk of inflammatory complications. CLINICAL RELEVANCE: Water is a very accessible, cost-effective irrigant without side effects and the results from this study have proven that it can be used to reduce the risk of inflammatory complications and associated morbidity following lower third molar removal. FAU - Ghaeminia, H AU - Ghaeminia H AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, The Netherlands. hossein.ghaeminia@radboudumc.nl. FAU - Hoppenreijs, Th J M AU - Hoppenreijs TJ AD - Department of Oral and Maxillofacial Surgery, Rijnstate Hospital Arnhem, Wagnerlaan 55, 6815 AD, Arnhem, The Netherlands. FAU - Xi, T AU - Xi T AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, The Netherlands. FAU - Fennis, J P AU - Fennis JP AD - Department of Oral and Maxillofacial Surgery, Rijnstate Hospital Arnhem, Wagnerlaan 55, 6815 AD, Arnhem, The Netherlands. FAU - Maal, T J AU - Maal TJ AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, The Netherlands. FAU - Bergé, S J AU - Bergé SJ AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, The Netherlands. AD - Oral and Maxillofacial Surgery, ZBC Private Clinic Nijmegen, Groenewoudseweg 315, 6524 TX, Nijmegen, The Netherlands. FAU - Meijer, G J AU - Meijer GJ AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, The Netherlands. AD - Implantology & Periodontology, Radboud University Medical Center, Phillips van Leydenlaan 25, 6525 EX, Nijmegen, The Netherlands. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20160227 TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Drinking Water) SB - D MH - Adolescent MH - Adult MH - *Drinking Water MH - Dry Socket/epidemiology/prevention & control MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Postoperative Complications/epidemiology/*prevention & control MH - Risk Factors MH - Surgical Wound Infection/epidemiology/prevention & control MH - Syringes MH - Therapeutic Irrigation/*methods MH - *Tooth Socket MH - Tooth, Impacted/*surgery MH - Treatment Outcome PMC - PMC5203820 OTO - NOTNLM OT - Drinking water OT - Irrigation OT - Oral health impact profile OT - Pain OT - Prevention OT - Quality of life OT - Risk factors OT - Trismus COIS- Compliance with ethical standards This study was part of a multicenter randomized controlled clinical trial investigating the efficacy of CBCT prior to mandibular third molar removal from which the trial and the clinical protocol were approved by the Institutional Review Board (CCMO Arnhem-Nijmegen, NL nr.: 40492.091.12). Conflict of interest The authors declare that they have no conflict of interest. Funding The work was supported by the Department of Oral & Maxillofacial Surgery of Radboud University Medical Centre. The BOOA Research Foundation of the Dutch Society of the Oral and Maxillofacial Surgery furthermore supported this study. Informed consent All patients were informed about the study and a written informed consent was obtained. EDAT- 2016/02/29 06:00 MHDA- 2018/01/10 06:00 CRDT- 2016/02/29 06:00 PHST- 2015/12/23 00:00 [received] PHST- 2016/02/10 00:00 [accepted] PHST- 2016/02/29 06:00 [pubmed] PHST- 2018/01/10 06:00 [medline] PHST- 2016/02/29 06:00 [entrez] AID - 10.1007/s00784-016-1751-1 [pii] AID - 1751 [pii] AID - 10.1007/s00784-016-1751-1 [doi] PST - ppublish SO - Clin Oral Investig. 2017 Jan;21(1):71-83. doi: 10.1007/s00784-016-1751-1. Epub 2016 Feb 27. PMID- 12054719 OWN - NLM STAT- MEDLINE DCOM- 20021108 LR - 20131121 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 40 IP - 3 DP - 2002 Jun TI - Can warfarin be continued during dental extraction? Results of a randomized controlled trial. PG - 248-52 AB - A randomized controlled trial was set up to investigate whether patients who were taking warfarin and had an International Normalised Ratio (INR) within the normal therapeutic range require cessation of their anticoagulation drugs before dental extractions. Of 109 patients who completed the trial, 52 were allocated to the control group (warfarin stopped 2 days before extraction) and 57 patients were allocated to the intervention group (warfarin continued). The incidence of bleeding complications in the intervention group was higher (15/57, 26%) than in the control group (7/52, 14%) but this difference was not significant. Two patients in the study required hospital review for bleeding and all other episodes of bleeding were controlled by patients at home. Continuing warfarin when the INR is < 4.1 may lead to an increase in minor post-extraction bleeding after dental extractions but we found no evidence of an increase in clinically important bleeding. As there are risks associated with stopping warfarin, the practice of routinely discontinuing it before dental extractions should be reconsidered. CI - Copyright 2002 The British Association of Oral and Maxillofacial Surgeons. FAU - Evans, I L AU - Evans IL AD - Maxillofacial Unit, Morriston Hospital, Swansea, UK. FAU - Sayers, M S AU - Sayers MS FAU - Gibbons, A J AU - Gibbons AJ FAU - Price, G AU - Price G FAU - Snooks, H AU - Snooks H FAU - Sugar, A W AU - Sugar AW LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anesthetics, Local) RN - 0 (Anticoagulants) RN - 362O9ITL9D (Acetaminophen) RN - 5Q7ZVV76EI (Warfarin) RN - 98PI200987 (Lidocaine) SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 2003 Apr;41(2):132. PMID: 12694713 MH - Acetaminophen/therapeutic use MH - Adult MH - Aged MH - Aged, 80 and over MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthetics, Local/administration & dosage MH - Anticoagulants/administration & dosage/*therapeutic use MH - Chi-Square Distribution MH - Confidence Intervals MH - Female MH - Follow-Up Studies MH - Hemostasis, Surgical MH - Humans MH - International Normalized Ratio MH - Lidocaine/administration & dosage MH - Male MH - Middle Aged MH - Oral Hemorrhage/etiology MH - Postoperative Hemorrhage/etiology MH - Risk Factors MH - Statistics as Topic MH - *Tooth Extraction MH - Warfarin/administration & dosage/*therapeutic use EDAT- 2002/06/11 10:00 MHDA- 2002/11/26 04:00 CRDT- 2002/06/11 10:00 PHST- 2002/06/11 10:00 [pubmed] PHST- 2002/11/26 04:00 [medline] PHST- 2002/06/11 10:00 [entrez] AID - S0266435601907739 [pii] AID - 10.1054/bjom.2001.0773 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2002 Jun;40(3):248-52. doi: 10.1054/bjom.2001.0773. PMID- 24332521 OWN - NLM STAT- MEDLINE DCOM- 20141104 LR - 20140120 IS - 2212-4411 (Electronic) VI - 117 IP - 2 DP - 2014 Feb TI - Blue-violet light-emitting diode irradiation in combination with hemostatic gelatin sponge (Spongel) application ameliorates immediate socket bleeding in patients taking warfarin. PG - 170-7 LID - S2212-4403(13)00490-2 [pii] LID - 10.1016/j.oooo.2013.09.009 [doi] AB - OBJECTIVE: The control of bleeding after tooth extraction is a major concern in patients taking warfarin. Light-emitting diode (LED) irradiation with hemostatic gelatin sponge application was investigated. STUDY DESIGN: Patients who took warfarin and required tooth extraction were divided randomly into 3 groups. The first group was irradiated with blue-violet LED after tooth extraction. The second group was treated with a hemostatic gelatin sponge and LED irradiation. The third group was treated with only hemostatic gelatin sponges. Hemostasis was evaluated at 30 seconds after treatment. RESULTS: Less than 30% of the patients achieved hemostasis within 30 seconds in the hemostatic sponge group; approximately 50% of the patients in the simple LED irradiation group achieved hemostasis within 30 seconds; and 86.7% of the patients in the LED and hemostatic sponge combined group achieved hemostasis within 30 seconds, indicating that combined treatment with LED and hemostatic sponges provided a significantly higher hemostasis than in the hemostatic sponge group (P < .01). CONCLUSIONS: Blue-violet LED irradiation combined with hemostatic gelatin sponge treatment yielded hemostasis of the extraction socket within 30 seconds without suture in most cases. CI - Copyright © 2014 Elsevier Inc. All rights reserved. FAU - Okamoto, Toshihiro AU - Okamoto T AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Tokyo, Japan. FAU - Ishikawa, Isao AU - Ishikawa I AD - Consultant, Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: ishikawa.isao@twmu.ac.jp. FAU - Kumasaka, Akira AU - Kumasaka A AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Tokyo, Japan. FAU - Morita, Seigo AU - Morita S AD - Research Fellow, Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Tokyo, Japan. FAU - Katagiri, Sayaka AU - Katagiri S AD - Assistant Professor, Department of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan. FAU - Okano, Teruo AU - Okano T AD - Director, Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan. FAU - Ando, Tomohiro AU - Ando T AD - Professor and Chairman, Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Tokyo, Japan. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20131212 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Hemostatics) RN - 5Q7ZVV76EI (Warfarin) RN - 9000-70-8 (Gelatin) SB - D SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Gelatin/therapeutic use MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/etiology/*prevention & control MH - Phototherapy/*methods MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Surgical Sponges MH - *Tooth Extraction MH - Treatment Outcome MH - Warfarin/*administration & dosage EDAT- 2013/12/18 06:00 MHDA- 2014/11/05 06:00 CRDT- 2013/12/17 06:00 PHST- 2013/05/22 00:00 [received] PHST- 2013/09/05 00:00 [revised] PHST- 2013/09/09 00:00 [accepted] PHST- 2013/12/17 06:00 [entrez] PHST- 2013/12/18 06:00 [pubmed] PHST- 2014/11/05 06:00 [medline] AID - S2212-4403(13)00490-2 [pii] AID - 10.1016/j.oooo.2013.09.009 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):170-7. doi: 10.1016/j.oooo.2013.09.009. Epub 2013 Dec 12. PMID- 24820711 OWN - NLM STAT- MEDLINE DCOM- 20150702 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 25 IP - 3 DP - 2014 May TI - Hemostasis control in dental extractions in patients receiving oral anticoagulant therapy: an approach with calcium sulfate. PG - 843-6 LID - 10.1097/SCS.0000000000000824 [doi] AB - The aim of this study was to evaluate the use of calcium sulfate (CaS) as a hemostatic agent after tooth extraction in patients with anticoagulant drug therapy. A total of 30 patients undergoing anticoagulant therapy (22 women and 8 men) with a mean age of 54.6 years (SD = 9.2 years), needing dental extractions, were selected for this study. They were divided into 2 groups, control (group 1) and test (group 2), in a randomized way. In group 1 patients, the postextraction socket was managed with obliterative suture only. Group 2 patients were treated with CaS placed into the postextraction sockets. All the patients did not interrupt the anticoagulant therapy during the dental treatment. The healing pattern was found to be approximately similar in all treatment groups, showing significant improvement at each consecutive visit. However, a statistically significant difference in the adequate hemostasis was evident between groups 1 and 2 (P = 0.0056). The use of CaS helped to control the bleeding from inside the socket, producing instantly a very good hemostasis. Further studies are necessary to confirm the simplicity, possibilities, and limits of the proposed procedure. FAU - Scarano, Antonio AU - Scarano A AD - From the *Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy; †Department of Oral Rehabilitation, School of Dental Medicine, Tel-Aviv University, Israel; and ‡Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara, Italy. FAU - Sinjari, Bruna AU - Sinjari B FAU - Murmura, Giovanna AU - Murmura G FAU - Mijiritsky, Eitan AU - Mijiritsky E FAU - Iaculli, Flavia AU - Iaculli F FAU - Mortellaro, Carmen AU - Mortellaro C FAU - Tetè, Stefano AU - Tetè S LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Anticoagulants) RN - 0 (Hemostatics) RN - 5Q7ZVV76EI (Warfarin) RN - WAT0DDB505 (Calcium Sulfate) SB - D MH - Administration, Oral MH - Anticoagulants/administration & dosage/*therapeutic use MH - Blood Coagulation/drug effects MH - Calcium Sulfate/*therapeutic use MH - Female MH - Hemostasis, Surgical/*methods MH - Hemostatics/therapeutic use MH - Humans MH - International Normalized Ratio MH - Male MH - Middle Aged MH - Oral Hemorrhage/prevention & control MH - Postoperative Hemorrhage/prevention & control MH - *Tooth Extraction/adverse effects MH - Tooth Socket/surgery MH - Warfarin/administration & dosage/therapeutic use MH - Wound Closure Techniques MH - Wound Healing/physiology EDAT- 2014/05/14 06:00 MHDA- 2015/07/03 06:00 CRDT- 2014/05/14 06:00 PHST- 2014/05/14 06:00 [entrez] PHST- 2014/05/14 06:00 [pubmed] PHST- 2015/07/03 06:00 [medline] AID - 00001665-201405000-00029 [pii] AID - 10.1097/SCS.0000000000000824 [doi] PST - ppublish SO - J Craniofac Surg. 2014 May;25(3):843-6. doi: 10.1097/SCS.0000000000000824. PMID- 21925909 OWN - NLM STAT- MEDLINE DCOM- 20120427 LR - 20131121 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 112 IP - 6 DP - 2011 Dec TI - PSA block for maxillary molar's anesthesia - an obsolete technique? PG - e39-43 LID - 10.1016/j.tripleo.2011.04.046 [doi] AB - BACKGROUND: Routine use of posterior superior alveolar (PSA) nerve block or maxillary infiltration for the removal of maxillary molars has been validated. OBJECTIVE: The present study was undertaken to determine the relative contribution of posterior superior alveolar (PSA) block in cases of anesthesia required for maxillary molars. STUDY DESIGN: One hundred patients requiring removal of maxillary second and third molars were enrolled. These patients were divided into 2 groups. One group received infiltration for anesthesia and other group received PSA nerve block using lignocaine with vasoconstrictor. All extractions were performed using a consistent technique of intraalveolar extraction. Data relating to the pain during extraction obtained on a visual analog scale and a verbal response scale, requirement of repeated injection for anesthesia, efficacy of these injections in localized infections, and requirement of rescue analgesics 3 hours after extraction. RESULTS: Statistical data confirmed clinical equivalence between infiltration and PSA nerve block. CONCLUSIONS: Considering the difficulty in mastering the technique of PSA nerve block, and the possibility of more complications associated with it (compared with infiltration); it may not be necessary for anesthesia of maxillary molars. CI - Copyright © 2011 Mosby, Inc. All rights reserved. FAU - Padhye, Mukul AU - Padhye M AD - Department of Oral and Maxillofacial Surgery, Padmashree Dr. D Y Patil Dental College and Hospital, Navi Mumbai, India. FAU - Gupta, Savina AU - Gupta S FAU - Chandiramani, Girish AU - Chandiramani G FAU - Bali, Rati AU - Bali R LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110916 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Vasoconstrictor Agents) RN - 98PI200987 (Lidocaine) RN - YKH834O4BH (Epinephrine) SB - D SB - IM MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthesia, Dental/*methods MH - Anesthetics, Local/administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Epinephrine/administration & dosage MH - Hematoma/etiology MH - Humans MH - Injections/methods MH - Lidocaine/administration & dosage MH - Maxillary Nerve/*drug effects MH - Molar/*innervation/surgery MH - Molar, Third/innervation/surgery MH - Nerve Block/*methods MH - Pain Measurement MH - Pain, Postoperative/drug therapy MH - Periapical Diseases/complications MH - Postoperative Complications MH - Postoperative Hemorrhage/etiology MH - Tooth Extraction/*methods MH - Treatment Outcome MH - Trismus/etiology MH - Vasoconstrictor Agents/administration & dosage EDAT- 2011/09/20 06:00 MHDA- 2012/04/28 06:00 CRDT- 2011/09/20 06:00 PHST- 2011/04/06 00:00 [received] PHST- 2011/04/19 00:00 [accepted] PHST- 2011/09/20 06:00 [entrez] PHST- 2011/09/20 06:00 [pubmed] PHST- 2012/04/28 06:00 [medline] AID - S1079-2104(11)00332-5 [pii] AID - 10.1016/j.tripleo.2011.04.046 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Dec;112(6):e39-43. doi: 10.1016/j.tripleo.2011.04.046. Epub 2011 Sep 16. PMID- 21035237 OWN - NLM STAT- MEDLINE DCOM- 20120426 LR - 20131121 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 49 IP - 8 DP - 2011 Dec TI - Effect of submucosal and intramuscular dexamethasone on postoperative sequelae after third molar surgery: comparative study. PG - 647-52 LID - 10.1016/j.bjoms.2010.09.021 [doi] AB - We compared the effects of dexamethasone sodium phosphate given submucosally and intramuscularly on postoperative complications after removal of impacted lower third molars in a preliminary randomised prospective clinical trial. Thirty patients, each of whom required removal of a single impacted mandibular third molar under local anaesthesia, were randomly allocated to one of 3 groups of 10 each. The 2 experimental groups were given dexamethasone 4 mg submucosally or intramuscularly, and the control group had no steroid. Facial swelling and maximal interincisal distance were measured by an independent examiner at baseline (preoperatively), and at 1, 3, and 7 days postoperatively. Pain was measured by counting the number of rescue analgesic tablets taken, and from the patients' response to a visual analogue scale (VAS). The mean age of the 16 men and 14 women was 27 years (range 20-48). Both dexamethasone groups showed significant reductions in swelling (p<0.001) and in pain (p<0.05) compared with the control group at all intervals. Submucosal dexamethasone resulted in significantly less trismus than controls on day 1 postoperatively (p=0.04), but there were no significant differences among the groups at the other times. The effects of the two routes of dexamethasone were comparable for all variables. There were no cases of alveolar osteitis or wound infection. Dexamethasone 4 mg given submucosally is an effective way of minimising swelling, trismus, and pain after removal of impacted lower third molars, and is comparable with the intramuscular route. It offers a simple, safe, painless, non-invasive, and cost-effective treatment in moderate and severe cases. CI - Copyright © 2010 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Majid, Omer Waleed AU - Majid OW AD - Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul, Nineveh, Iraq. omerw_majid@yahoo.co.uk FAU - Mahmood, Waseem Khalid AU - Mahmood WK LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20101029 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Administration, Buccal MH - Adult MH - Analysis of Variance MH - Dexamethasone/*administration & dosage MH - Edema/etiology/prevention & control MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/etiology/*prevention & control MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Young Adult EDAT- 2010/11/03 06:00 MHDA- 2012/04/27 06:00 CRDT- 2010/11/02 06:00 PHST- 2010/06/05 00:00 [received] PHST- 2010/09/27 00:00 [accepted] PHST- 2010/11/02 06:00 [entrez] PHST- 2010/11/03 06:00 [pubmed] PHST- 2012/04/27 06:00 [medline] AID - S0266-4356(10)00314-1 [pii] AID - 10.1016/j.bjoms.2010.09.021 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2011 Dec;49(8):647-52. doi: 10.1016/j.bjoms.2010.09.021. Epub 2010 Oct 29. PMID- 23494104 OWN - NLM STAT- MEDLINE DCOM- 20151215 LR - 20181202 IS - 1435-604X (Electronic) IS - 0268-8921 (Linking) VI - 29 IP - 4 DP - 2014 Jul TI - Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus following impacted third-molar surgery. PG - 1313-9 LID - 10.1007/s10103-013-1300-y [doi] AB - This study aims to evaluate the efficacy of the ozone and laser application in the management of pain, swelling, and trismus after third-molar surgery. Sixty consecutive patients with asymptomatic impacted mandibular third molars were recruited into the study. Patients were randomized into three treatment groups of 20 patients each: two study groups (group 1 = low-level laser therapy (LLLT), group 2 = ozone therapy) and a control group (no-LLLT or ozone therapy). Twenty teeth extractions were performed in each group. Evaluations of postoperative pain, the number of analgesics tablets taken, trismus, swelling, and quality of life (Oral Health Impact Profile-14 questionnaire) were made. The sample consisted of 28 female and 32 male patients, whose total mean age was 23.5 ± 3.4 (range, 18-25) years. The pain level and the number of analgesics tablets taken were lower in the ozonated and LLLT applied groups than in the control group. This study showed that ozone and low power laser therapies had a positive effect on the patients' quality of life. Trismus in the LLLT group was significantly less than in the ozonated and control groups (p = 0.033). Ozone application showed no superiority in regards of postoperative swelling; however, LLLT group had significantly lower postoperative swelling. This study demonstrates that ozone and laser therapies are useful for the reduction of postoperative pain and they increase quality of life after third-molar surgery. Although the ozone therapy had no effect on postoperative swelling and trismus after surgical removal of impacted lower third molars, LLLT had a positive effect. FAU - Kazancioglu, Hakki Oguz AU - Kazancioglu HO AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey, dt_oguz@yahoo.com. FAU - Ezirganli, Seref AU - Ezirganli S FAU - Demirtas, Nihat AU - Demirtas N LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130314 PL - England TA - Lasers Med Sci JT - Lasers in medical science JID - 8611515 RN - 0 (Analgesics) RN - 66H7ZZK23N (Ozone) SB - IM CIN - Lasers Med Sci. 2015 Jul;30(5):1627. PMID: 24292198 MH - Adolescent MH - Adult MH - Analgesics/therapeutic use MH - Edema/etiology/*therapy MH - Female MH - Humans MH - *Low-Level Light Therapy MH - Male MH - Molar, Third/*surgery MH - Ozone/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/drug therapy/etiology/*therapy MH - Surveys and Questionnaires MH - Tooth, Impacted/*surgery MH - Trismus/etiology/*therapy EDAT- 2013/03/16 06:00 MHDA- 2015/12/17 06:00 CRDT- 2013/03/16 06:00 PHST- 2012/12/12 00:00 [received] PHST- 2013/03/01 00:00 [accepted] PHST- 2013/03/16 06:00 [entrez] PHST- 2013/03/16 06:00 [pubmed] PHST- 2015/12/17 06:00 [medline] AID - 10.1007/s10103-013-1300-y [doi] PST - ppublish SO - Lasers Med Sci. 2014 Jul;29(4):1313-9. doi: 10.1007/s10103-013-1300-y. Epub 2013 Mar 14. PMID- 20116702 OWN - NLM STAT- MEDLINE DCOM- 20100217 LR - 20151119 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 68 IP - 2 DP - 2010 Feb TI - Use of therapeutic laser after surgical removal of impacted lower third molars. PG - 319-24 LID - 10.1016/j.joms.2009.07.037 [doi] AB - PURPOSE: To evaluate the effectiveness of a therapeutic laser in the control of postoperative pain, swelling, and trismus associated with the surgical removal of impacted third molars. PATIENTS AND METHODS: A double-blind, randomized, controlled clinical trial was conducted in 2 groups of 15 patients each undergoing surgical removal of impacted lower third molars under local anesthesia. The experimental group received 4 J/cm(2) of energy density intraorally and extraorally, with a laser with a diode wavelength of 810 nm and output power of 100 mW in a continuous wave. The control group received only standard management. The degree of postoperative pain, swelling, and trismus was registered for both groups. RESULTS: The experimental group exhibited a lower intensity of postoperative pain, swelling, and trismus than the control group, without significant statistical differences. Patients of both groups required rescue medication; however, the time lapse between the end of the surgery and the administration of the medication was shorter for the control group. CONCLUSION: The use of therapeutic laser in the postoperative management of patients having surgical removal of impacted third molars, using the protocol of this study, decreases postoperative pain, swelling, and trismus, without statistically significant differences. CI - Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Amarillas-Escobar, E Darío AU - Amarillas-Escobar ED AD - Service of Oral and Maxillofacial Surgery, Hospital Central, Dr. Ignacio Morones Prieto, San Luis Potosí, Mexico. FAU - Toranzo-Fernández, J Martin AU - Toranzo-Fernández JM FAU - Martínez-Rider, Ricardo AU - Martínez-Rider R FAU - Noyola-Frías, Miguel A AU - Noyola-Frías MA FAU - Hidalgo-Hurtado, J Antonio AU - Hidalgo-Hurtado JA FAU - Serna, Víctor M Fierro AU - Serna VM FAU - Gordillo-Moscoso, Antonio AU - Gordillo-Moscoso A FAU - Pozos-Guillén, Amaury J AU - Pozos-Guillén AJ LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20100115 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Double-Blind Method MH - Edema/prevention & control MH - Female MH - Humans MH - Lasers, Semiconductor/*therapeutic use MH - *Low-Level Light Therapy MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Young Adult EDAT- 2010/02/02 06:00 MHDA- 2010/02/18 06:00 CRDT- 2010/02/02 06:00 PHST- 2008/11/28 00:00 [received] PHST- 2009/04/13 00:00 [revised] PHST- 2009/07/25 00:00 [accepted] PHST- 2010/02/02 06:00 [entrez] PHST- 2010/02/02 06:00 [pubmed] PHST- 2010/02/18 06:00 [medline] AID - S0278-2391(09)01430-X [pii] AID - 10.1016/j.joms.2009.07.037 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2010 Feb;68(2):319-24. doi: 10.1016/j.joms.2009.07.037. Epub 2010 Jan 15. PMID- 25522940 OWN - NLM STAT- MEDLINE DCOM- 20150821 LR - 20181202 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 15 IP - 4 DP - 2014 Dec TI - Ibuprofen is superior to paracetamol for pain relief following third molar removal. PG - 106-7 LID - 10.1038/sj.ebd.6401059 [doi] AB - DATA SOURCES: The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the metaRegister of Controlled Trials were searched with no language restrictions. STUDY SELECTION: Randomised controlled double-blinded clinical trials using the third molar model were included. DATA EXTRACTION AND SYNTHESIS: Two review authors independently and in duplicate extracted data. The proportion of patients with at least 50% pain relief (based on total pain relief (TOTPAR) and summed pain intensity difference (SPID) data) was calculated for all three drugs at both two and six hours post-dosing and meta-analysed for comparison. RESULTS: Seven studies involving 2241 patients were included. Two studies were considered to be at low risk of bias, three at high risk and two unclear risk of bias. Ibuprofen was found to be a superior analgesic to paracetamol at several doses, with high quality evidence suggesting that ibuprofen 400 mg is superior to 1000 mg paracetamol based on pain relief (estimated from TOTPAR data) and the use of rescue medication meta-analyses. Risk ratio (RR) for at least 50% pain relief (based on TOTPAR) at six hours was 1.47 (95% confidence interval (CI) 1.28 to 1.69; five trials) favouring 400 mg ibuprofen over 1000 mg paracetamol, RR for not using rescue medication (also favouring ibuprofen) was 1.50 (95% CI 1.25 to 1.79; four trials). For combined drug RR for at least 50% of the maximum pain relief over six hours of 1.77 (95% CI 1.32 to 2.39) (paracetamol 1000 mg and ibuprofen 400 mg) (one trial; moderate quality evidence). RR not using rescue medication 1.60 (95% CI 1.36 to 1.88) (two trials; moderate quality evidence). Adverse events were comparable between the treatment groups, but no formal analysis could be undertaken. CONCLUSIONS: There is high quality evidence that ibuprofen is superior to paracetamol at doses of 200 mg to 512 mg and 600 mg to 1000 mg respectively based on pain relief and use of rescue medication data collected at six hours postoperatively. The majority of this evidence (five out of six trials) compared ibuprofen 400 mg with paracetamol 1000 mg, these are the most frequently prescribed doses in clinical practice. The novel combination drug is showing encouraging results based on the outcomes from two trials when compared to the single drugs. FAU - Ferraiolo, Debra M AU - Ferraiolo DM AD - NYU College of Dentistry, New York, USA. FAU - Veitz-Keenan, Analia AU - Veitz-Keenan A AD - NYU College of Dentistry, New York, USA. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM CON - Cochrane Database Syst Rev. 2013;12:CD004624. PMID: 24338830 MH - Acetaminophen/*administration & dosage MH - Analgesics, Non-Narcotic/*administration & dosage MH - Humans MH - Ibuprofen/*administration & dosage MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*adverse effects EDAT- 2014/12/20 06:00 MHDA- 2015/08/22 06:00 CRDT- 2014/12/20 06:00 PHST- 2014/12/20 06:00 [entrez] PHST- 2014/12/20 06:00 [pubmed] PHST- 2015/08/22 06:00 [medline] AID - 6401059 [pii] AID - 10.1038/sj.ebd.6401059 [doi] PST - ppublish SO - Evid Based Dent. 2014 Dec;15(4):106-7. doi: 10.1038/sj.ebd.6401059. PMID- 15022536 OWN - NLM STAT- MEDLINE DCOM- 20040406 LR - 20151119 IS - 1064-6655 (Print) IS - 1064-6655 (Linking) VI - 18 IP - 1 DP - 2004 Winter TI - Effect of dexamethasone and dipyrone on lingual and inferior alveolar nerve hypersensitivity following third molar extractions: preliminary report. PG - 62-8 AB - AIMS: To study the effect of dexamethazone and dipyrone on sensory changes in the innervation territories of the inferior alveolar, infraorbital, and lingual nerves caused by third molar extractions. METHODS: Fourteen patients (8 men and 6 women) were divided randomly into 2 groups. The first group received dipyrone preoperatively, while the second group received dipyrone and dexamethazone preoperatively. All patients in the study received a prophylactic preoperative dose of amoxicillin (500 mg) as well as dipyrone postoperatively. In all patients, a single mandibular third molar was removed, while in 2 patients the contralateral third molar was removed at a subsequent time. Electrical detection thresholds were assessed in the inferior alveolar, lingual, and infraorbital nerve regions prior to surgery and 2 and 8 days following surgery. The level of perioperative pain, difficulty of extraction, and distance of molar root apices from the inferior alveolar nerve canal were also assessed. RESULTS: Patients who received only dipyrone had significantly reduced lingual and inferior alveolar nerve electrical detection thresholds 2 days after surgery, which returned to nearly baseline values by the eighth day postoperatively. In patients who received dexamethasone, no significant reduction in the electrical detection threshold was found. CONCLUSION: Preoperative treatment with dexamethasone and dipyrone but not dipyrone alone prevents sensory hypersensitivity following third molar extraction. FAU - Barron, Robert P AU - Barron RP AD - Department of Oral Medicine, Hebrew University School of Dental Medicine, Hadassah Medical Center, Jerusalem, Israel. rbarron@rogers.com FAU - Benoliel, Raphael AU - Benoliel R FAU - Zeltser, Raphael AU - Zeltser R FAU - Eliav, Eli AU - Eliav E FAU - Nahlieli, Oded AU - Nahlieli O FAU - Gracely, Richard H AU - Gracely RH LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Orofac Pain JT - Journal of orofacial pain JID - 9418507 RN - 0 (Anti-Inflammatory Agents) RN - 6429L0L52Y (Dipyrone) RN - 7S5I7G3JQL (Dexamethasone) SB - D MH - Anti-Inflammatory Agents/*administration & dosage MH - Cranial Nerve Injuries/etiology/physiopathology MH - Dexamethasone/*administration & dosage MH - Dipyrone/*administration & dosage MH - Electric Stimulation MH - Female MH - Humans MH - *Lingual Nerve/*physiopathology MH - Lingual Nerve Injuries MH - Male MH - *Mandibular Nerve/physiopathology MH - Molar, Third/surgery MH - Neuritis/complications/etiology/physiopathology MH - Orbit/innervation MH - Pain Measurement MH - Pain, Postoperative/etiology/*prevention & control MH - Preoperative Care MH - Sensory Thresholds/*drug effects MH - Somatosensory Disorders/etiology/*prevention & control MH - Tooth Extraction/*adverse effects MH - Trigeminal Nerve Injuries EDAT- 2004/03/17 05:00 MHDA- 2004/04/07 05:00 CRDT- 2004/03/17 05:00 PHST- 2004/03/17 05:00 [pubmed] PHST- 2004/04/07 05:00 [medline] PHST- 2004/03/17 05:00 [entrez] PST - ppublish SO - J Orofac Pain. 2004 Winter;18(1):62-8. PMID- 25567713 OWN - NLM STAT- MEDLINE DCOM- 20150529 LR - 20181202 IS - 1002-0098 (Print) IS - 1002-0098 (Linking) VI - 49 IP - 10 DP - 2014 Oct TI - [Effect of antibiotics on postoperative inflammatory complications after surgical extraction of the impacted mandibular third molar]. PG - 603-6 AB - OBJECTIVE: To investigate the effect of antibiotics on postoperative inflammatory complications after surgical extraction of the impacted mandibular third molar. METHODS: Ninety-Six patients had their bilateral third molars removed through a split-mouth, double-blind, controlled, clinical trial in two visits. On one side amoxicillin (or clindamycin) was used (antibiotics group) from 1 h pre-operation to 3 d post-operation. On the other side, placebo was used (placebo group) the same time. Postoperative inflammatory complications including alveolar osteitis (AO), surgical site infection (SSI), pre-buccal site infection and anterior isthmus faucium space infection were monitored and recorded 2 d and 10 d after the surgery. The pain, swelling, and trismus were also recorded. RESULTS: All 96 patients completed the study. Two AO (2.1%), one SSI (1.0%) and seven other infections were observed in the treatment group. Also three AO (3.1%), one SSI (1.0%) and eleven other infections were observed in the placebo group. However, no statistically significant differences were found in the incidence of various postoperative inflammatory complications and reactions between the groups (P > 0.05). There was no significant difference on the postoperative reaction, except pain on 10 d. Patients who had inflammatory infection recovered well with symptomatic anti-infection treatment. CONCLUSIONS: The use of amoxicillin (or clindamycin) cannot effectively prevent and reduce the postoperative inflammatory complications after surgical extraction of the impacted mandibular third molar. FAU - Xue, Peng AU - Xue P AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. FAU - Hou, Rui AU - Hou R AD - Email: hourui@fmmu.edu.cn. FAU - Shang, Lei AU - Shang L FAU - Ma, Yuanyuan AU - Ma Y FAU - Wu, Fang AU - Wu F FAU - Zhang, Sijia AU - Zhang S LA - chi PT - Journal Article PT - Randomized Controlled Trial PL - China TA - Zhonghua Kou Qiang Yi Xue Za Zhi JT - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology JID - 8711066 RN - 0 (Anti-Bacterial Agents) RN - 0 (Anti-Infective Agents, Local) RN - 3U02EL437C (Clindamycin) RN - 804826J2HU (Amoxicillin) SB - D SB - IM MH - Amoxicillin/*therapeutic use MH - Anti-Bacterial Agents MH - Anti-Infective Agents, Local MH - Clindamycin/*therapeutic use MH - Double-Blind Method MH - Dry Socket MH - Edema MH - Humans MH - Molar MH - Molar, Third MH - Surgical Wound Infection/*prevention & control MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2015/01/09 06:00 MHDA- 2015/05/30 06:00 CRDT- 2015/01/09 06:00 PHST- 2015/01/09 06:00 [entrez] PHST- 2015/01/09 06:00 [pubmed] PHST- 2015/05/30 06:00 [medline] PST - ppublish SO - Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Oct;49(10):603-6. PMID- 29752604 OWN - NLM STAT- MEDLINE DCOM- 20190828 LR - 20190828 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 22 IP - 2 DP - 2018 Jun TI - A comparative study of the effect of two dosages of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective randomized study. PG - 225-230 LID - 10.1007/s10006-018-0699-5 [doi] AB - INTRODUCTION: The aim of this clinical study was to evaluate and compare the relative efficacy of two different dosages of dexamethasone, i.e., 4 and 8 mg injected submucosally to reduce postoperative discomfort after mandibular third molar surgery. METHODOLOGY: A prospective randomized study was conducted on 45 patients requiring surgical removal of an impacted third molar. Selected patients were divided randomly into three groups of 15 patients each: group I patients received one regimen single dose of 4 mg dexamethasone submucosally, group II received one regimen single dose of 8 mg dexamethasone submucosally, and group III (control group), no dexamethasone was given but only received injection of normal saline submucosally after establishing local anesthesia. The postoperative sequelae were assessed on the second and seventh postoperative day. RESULT: As compared to group III, groups I and II showed statistically significant reduction in pain and swelling whereas no statistically significant difference was found between the test groups. CONCLUSION: It can be concluded that corticosteroids are effective in curtailing the postoperative edema of lower third molar surgery but have negligible analgesic effect. As no statistically significant difference is found between both the regimes of dexamethasone, i.e., 4 and 8 mg so within the confines of our study, it may be concluded that 4 mg dexamethasone can be given safely to reduce the postoperative edema after the third molar surgery. FAU - Arora, Srimathy S AU - Arora SS AD - Department of Oral and Maxillofacial Surgery, Swami Devi Dyal Hospital & Dental College, Barwala, Panchkula, India. FAU - Phull, Tanvi AU - Phull T AD - Department of Oral and Maxillofacial Surgery, Swami Devi Dyal Hospital & Dental College, Barwala, Panchkula, India. FAU - Kumar, Ish AU - Kumar I AD - Department of Oral and Maxillofacial Surgery, Swami Devi Dyal Hospital & Dental College, Barwala, Panchkula, India. ishpahwa@yahoo.com. FAU - Kumar, Arun AU - Kumar A AD - Department of Oral and Maxillofacial Surgery, PGIMER, Chandigarh, India. FAU - Kumar, Nilesh AU - Kumar N AD - Department of Oral and Maxillofacial Surgery, Swami Devi Dyal Hospital & Dental College, Barwala, Panchkula, India. FAU - Singh, Hem AU - Singh H AD - Department of Oral and Maxillofacial Surgery, Swami Devi Dyal Hospital & Dental College, Barwala, Panchkula, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20180512 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Adjuvants, Anesthesia) RN - 0 (Anti-Inflammatory Agents) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adjuvants, Anesthesia/administration & dosage/*therapeutic use MH - Adult MH - Anesthesia, Dental/*methods MH - Anesthesia, Local/*methods MH - Anti-Inflammatory Agents/administration & dosage/*therapeutic use MH - Dexamethasone/administration & dosage/*therapeutic use MH - Female MH - Humans MH - Injections MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Single-Blind Method MH - *Tooth Extraction/adverse effects/methods MH - Tooth, Impacted/*surgery MH - Young Adult OTO - NOTNLM OT - Dexamethasone OT - Impacted third molar OT - Submucosally EDAT- 2018/05/13 06:00 MHDA- 2019/08/29 06:00 CRDT- 2018/05/13 06:00 PHST- 2017/10/14 00:00 [received] PHST- 2018/05/04 00:00 [accepted] PHST- 2018/05/13 06:00 [pubmed] PHST- 2019/08/29 06:00 [medline] PHST- 2018/05/13 06:00 [entrez] AID - 10.1007/s10006-018-0699-5 [pii] AID - 10.1007/s10006-018-0699-5 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2018 Jun;22(2):225-230. doi: 10.1007/s10006-018-0699-5. Epub 2018 May 12. PMID- 27980326 OWN - NLM STAT- MEDLINE DCOM- 20180123 LR - 20181202 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 17 IP - 4 DP - 2016 Dec TI - Cone beam computed tomography in pre-surgical assessment of mandibular third molars. PG - 117-118 LID - 10.1038/sj.ebd.6401206 [doi] AB - DesignMulticentre, randomised controlled clinical trial.InterventionPatients referred for third molar removal received a digital panoramic radiograph(PR). Adults with one or more lower third molars in a close relationship with the mandibular canal were eligible for the study. Patients randomised to the cone beam computed tomography (CBCT) group received a high resolution CBCT scan in addition to the PR. All lower third molar extractions were performed under local anaesthesia without sedation and without antibiotic prophylaxis. Information on variables such as experience of the surgeon, duration of surgery and technique for third molar removal were recorded.Outcome measureThe primary outcome measure was the number of patient-reported altered sensations one week after surgery. Secondary outcomes included the number of patients with an objective IAN injury; permanent IAN injury (>6 months); occurrence of other postoperative complications (wound infection, alveolar osteitis); Oral Health Related Quality of Life-14, questionnaire responses; pain (VAS score); duration of surgery; number of emergency visits; and number of missed days of work or study.ResultsThree hundred and forty-one patients with 477 lower third molars were randomised from three centres. Two hundred and sixty-eight patients with 320 mandibular third molars were analysed according to the intention-to-treat principle for the primary and secondary outcomes. The overall incidence of patient-reported altered sensations one week after surgery was 6.3%. At one week there was no difference in subjective IAN injury between the CBCT and PR group. No significant differences were noted between the two groups for any of the secondary outcomes recorded.ConclusionsAlthough CBCT is a valuable diagnostic adjunct for identification of an increased risk for IAN injury, the use of CBCT does not translate into a reduction of IAN injury and other postoperative complications, after removal of the complete mandibular third molar. In these selected cases with a high risk for IAN injury, an alternative strategy, such as monitoring or a coronectomy, might be more appropriate. FAU - Fee, Patrick A AU - Fee PA AD - University of Dundee Dental School, Dundee, Scotland, UK. FAU - Wright, Alison AU - Wright A AD - Dundee Dental Hospital and School, Dundee, Scotland, UK. FAU - Cunningham, Claudia AU - Cunningham C AD - University of Aberdeen Dental School, Aberdeen, Scotland, UK. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 SB - D SB - IM CON - J Craniomaxillofac Surg. 2015 Dec;43(10):2158-67. PMID: 26596360 MH - *Cone-Beam Computed Tomography MH - Evidence-Based Dentistry MH - Humans MH - Molar, Third/*diagnostic imaging/*surgery MH - Postoperative Complications/*prevention & control MH - Radiography, Panoramic MH - Trigeminal Nerve Injuries/*prevention & control EDAT- 2016/12/17 06:00 MHDA- 2018/01/24 06:00 CRDT- 2016/12/17 06:00 PHST- 2016/12/17 06:00 [entrez] PHST- 2016/12/17 06:00 [pubmed] PHST- 2018/01/24 06:00 [medline] AID - 6401206 [pii] AID - 10.1038/sj.ebd.6401206 [doi] PST - ppublish SO - Evid Based Dent. 2016 Dec;17(4):117-118. doi: 10.1038/sj.ebd.6401206. PMID- 25711726 OWN - NLM STAT- MEDLINE DCOM- 20180109 LR - 20181113 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 19 IP - 3 DP - 2015 Sep TI - Comparative study of hemodynamic changes caused by diazepam and midazolam during third molar surgery: a randomized controlled trial. PG - 267-73 LID - 10.1007/s10006-015-0488-3 [doi] AB - The aim of the present study was to compare hemodynamic changes using midazolam 7.5 mg and diazepam 10.0 mg during the surgical removal of symmetrically positioned third molars. A prospective, randomized, double-blind, clinical trial was carried out involving 120 patients divided into three groups: Group 1 (diazepam and placebo), Group 2 (midazolam and placebo), and Group 3 (diazepam and midazolam). Each subject underwent two surgeries on separate occasions under local anesthesia. The following parameters were assessed at five different times (T0, T1, T2, T3, and T4): systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP, respectively); heart rate (HR); oxygen saturation (SpO(2)); rate pressure product (RPP); and pressure rate quotient (PRQ). Statistically significant differences were found regarding heart rate at T2 and T3 (p < 0.005) in Group 2, with a higher rate occurring during midazolam administration. Moreover, significant differences in rate pressure product were found at T2, T3, and T4 in this group, with higher values also occurring during midazolam administration. In Group 3, significant differences in diastolic blood pressure were found at T3 and T4, with higher values occurring during diazepam administration, whereas a higher heart rate occurred at T3 with midazolam. Midazolam 7.5 mg and diazepam 10.0 mg exert an influence on some hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar surgery. FAU - de Morais, Hécio Henrique Araújo AU - de Morais HH AD - Oral and Maxillofacial Department, Dental School of Pernambuco, University of Pernambuco, Av. General Newton Cavalcanti, 1650 Tabatinga, Camaragibe, Pernambuco, 54.756-220, Brazil. FAU - Barbalho, Jimmy Charles Melo AU - Barbalho JC FAU - de Holanda Vasconcellos, Ricardo José AU - de Holanda Vasconcellos RJ FAU - Landim, Fabricio Souza AU - Landim FS FAU - da Costa Araújo, Fábio Andrey AU - da Costa Araújo FA FAU - de Souza Dias, Tasiana Guedes AU - de Souza Dias TG LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150225 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - Q3JTX2Q7TU (Diazepam) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Adolescent MH - Adult MH - *Anesthesia, Dental MH - Dental Anxiety/*drug therapy/psychology MH - *Diazepam MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Hemodynamics/*drug effects MH - Humans MH - Male MH - *Midazolam MH - Molar, Third/*surgery MH - Pilot Projects MH - Tooth Extraction/*psychology MH - Young Adult EDAT- 2015/02/26 06:00 MHDA- 2018/01/10 06:00 CRDT- 2015/02/26 06:00 PHST- 2014/11/17 00:00 [received] PHST- 2015/02/15 00:00 [accepted] PHST- 2015/02/26 06:00 [entrez] PHST- 2015/02/26 06:00 [pubmed] PHST- 2018/01/10 06:00 [medline] AID - 10.1007/s10006-015-0488-3 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2015 Sep;19(3):267-73. doi: 10.1007/s10006-015-0488-3. Epub 2015 Feb 25. PMID- 23792405 OWN - NLM STAT- MEDLINE DCOM- 20140303 LR - 20181203 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 14 IP - 2 DP - 2013 TI - Coronectomy may be a way of managing impacted third molars. PG - 57-8 LID - 10.1038/sj.ebd.6400939 [doi] AB - DATA SOURCES: TPubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL) and the grey literature database SIGLE. STUDY SELECTION: Randomised controlled trials (RCTs) and non-randomised controlled trials (CCTs) that compared coronectomy with total removal for third molar extractions with high risk of nerve injury were included. DATA EXTRACTION AND SYNTHESIS: Data were extracted independently and in duplicate by two reviewers. Risk of bias was assessed according to the Cochrane Reviewers' Handbook. Meta-analysis and sensitivity analysis were performed. RESULTS: Four studies (two RCTs and two CCTs) involving 699 patients and 940 third molars were included. Pooled risk ratios for coronectomy compared with total removal are shown in table 1.Coronectomy was changed to total removal during surgery due to root loosening or mobilisation in 2.3% to 38.3% of cases. In 0% to 4.9% of cases reoperation was required in the coronectomy group due to persistent pain, root exposure or persistent apical infections. Root migration was only reported in three studies and ranged from 13.2% to 85.9%. CONCLUSIONS: We suggest that coronectomy can protect inferior alveolar nerves in the extraction of third molars with high risk of nerve injury as compared with total removal, and that the risk ratios of post-operative infections were similar between the two surgical modalities. FAU - Ghaeminia, Hossein AU - Ghaeminia H AD - Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 SB - D SB - IM CON - J Dent Res. 2012 Jul;91(7):659-65. PMID: 22622663 CIN - Br Dent J. 2013 Aug;215(3):103. PMID: 23928583 MH - Humans MH - Molar, Third/*surgery MH - Tooth Crown/*surgery MH - Tooth Extraction/*methods MH - Trigeminal Nerve Injuries/*prevention & control EDAT- 2013/06/26 06:00 MHDA- 2014/03/04 06:00 CRDT- 2013/06/25 06:00 PHST- 2013/06/25 06:00 [entrez] PHST- 2013/06/26 06:00 [pubmed] PHST- 2014/03/04 06:00 [medline] AID - 6400939 [pii] AID - 10.1038/sj.ebd.6400939 [doi] PST - ppublish SO - Evid Based Dent. 2013;14(2):57-8. doi: 10.1038/sj.ebd.6400939. PMID- 28068186 OWN - NLM STAT- MEDLINE DCOM- 20180109 LR - 20180109 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 35 IP - 4 DP - 2017 Apr TI - Bactericidal Efficacy of Photodynamic Therapy and Chitosan in Root Canals Experimentally Infected with Enterococcus faecalis: An In Vitro Study. PG - 184-189 LID - 10.1089/pho.2016.4148 [doi] AB - OBJECTIVE: To evaluate the antibacterial efficacy of photodynamic therapy (PDT) and chitosan against Enterococcus faecalis and assess the possible enhancive effect of chitosan on the photosensitizer methylene blue in experimentally infected root canals of extracted human teeth in vitro. BACKGROUND DATA: E. faecalis is frequently found in persistent endodontic infections. In this context, the antimicrobial PDT or newer antibacterial alternatives such as chitosan could become modern alternatives to existing antibacterial treatment approaches. METHODS: One hundred two single-rooted extracted teeth were used. The teeth were contaminated with 0.1 mL E. faecalis (3 × 10(8) cell/mL). These were randomized into six treatment groups (n = 17 teeth): Group 1 (2.5% NaOCl); Group 2 (PDT); Group 3 (chitosan 3 mg/mL); Group 4 (PDT+chitosan 3 mg/mL); Group 5 (positive control, no treatment); and Group 6 (negative control, no inoculation, no treatment). The canal content was sampled with sterile paper points. The samples were cultured on blood agar plates to determine the number of colony-forming units (CFU)/mL. Five teeth in each group were analyzed by scanning electron microscope (SEM) to determine the percentage of area with contamination and debris. RESULTS: The positive control group showed the highest number of CFU/mL, with statistically significant differences in comparison with the other treatment groups (p ≤ 0.05). Group 4 (PDT+chitosan) showed the lowest CFU/mL count, followed by Group 2 (PDT alone), which obtained similar results to Group 1 (NaOCl), but there was no significance between the treated groups. SEM images showed that Group 4 (PDT+Chitosan) showed the lowest area of contamination. CONCLUSIONS: Combination of PDT and chitosan showed antibacterial potential against endodontic infection by E. faecalis. FAU - Camacho-Alonso, Fabio AU - Camacho-Alonso F AD - 1 Department of Oral Surgery, University of Murcia , Murcia, Spain . FAU - Julián-Belmonte, Encarnación AU - Julián-Belmonte E AD - 2 Private dental practice , Murcia, Spain . FAU - Chiva-García, Fernando AU - Chiva-García F AD - 3 Department of Operative and Endodontics, University of Murcia , Murcia, Spain . FAU - Martínez-Beneyto, Yolanda AU - Martínez-Beneyto Y AD - 4 Department of Preventive and Community Dentistry, University of Murcia , Murcia, Spain . LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20170109 PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 RN - 9012-76-4 (Chitosan) SB - IM MH - Chitosan/*pharmacology MH - Dental Pulp Cavity/*drug effects/*microbiology MH - Enterococcus faecalis/drug effects/*pathogenicity MH - Gram-Positive Bacterial Infections/*drug therapy MH - Humans MH - In Vitro Techniques MH - Photochemotherapy/*methods MH - Reference Values MH - Risk Factors MH - Root Canal Preparation/methods MH - Sensitivity and Specificity MH - Tooth Extraction OTO - NOTNLM OT - Enterococcus faecalis OT - chitosan OT - endodontic OT - infected root canals OT - photodynamic therapy EDAT- 2017/01/10 06:00 MHDA- 2018/01/10 06:00 CRDT- 2017/01/10 06:00 PHST- 2017/01/10 06:00 [pubmed] PHST- 2018/01/10 06:00 [medline] PHST- 2017/01/10 06:00 [entrez] AID - 10.1089/pho.2016.4148 [doi] PST - ppublish SO - Photomed Laser Surg. 2017 Apr;35(4):184-189. doi: 10.1089/pho.2016.4148. Epub 2017 Jan 9. PMID- 4553818 OWN - NLM STAT- MEDLINE DCOM- 19720703 LR - 20190501 IS - 0007-1447 (Print) IS - 0007-1447 (Linking) VI - 2 IP - 5809 DP - 1972 May 6 TI - Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease. PG - 311-3 AB - In a double-blind trial tranexamic acid (AMCA, Cyclokapron), 1 g three times a day for five days, significantly reduced blood loss and transfusion requirements after dental extraction in patients with haemophilia and Christmas disease. No side effects were seen in either group of patients. Screening tests showed no toxic action of tranexamic acid on the liver, kidney, or heart. FAU - Forbes, C D AU - Forbes CD FAU - Barr, R D AU - Barr RD FAU - Reid, G AU - Reid G FAU - Thomson, C AU - Thomson C FAU - Prentice, C R AU - Prentice CR FAU - McNicol, G P AU - McNicol GP FAU - Douglas, A S AU - Douglas AS LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TA - Br Med J JT - British medical journal JID - 0372673 RN - 0 (Antifibrinolytic Agents) RN - 0 (Chromium Isotopes) RN - 0 (Cyclohexanecarboxylic Acids) RN - 8W8T17847W (Urea) RN - 9001-32-5 (Fibrinogen) SB - AIM SB - IM MH - Adolescent MH - Adult MH - Aged MH - Antifibrinolytic Agents/*therapeutic use MH - Blood Sedimentation MH - Chromium Isotopes MH - Clinical Trials as Topic MH - Cyclohexanecarboxylic Acids/*therapeutic use MH - Fibrinogen/analysis MH - Heart Function Tests MH - *Hemophilia A MH - *Hemophilia B MH - Humans MH - Kidney Function Tests MH - Liver Function Tests MH - Middle Aged MH - Oral Hemorrhage/*prevention & control MH - Tooth Extraction/*adverse effects MH - Urea/blood PMC - PMC1788188 EDAT- 1972/05/06 00:00 MHDA- 1972/05/06 00:01 CRDT- 1972/05/06 00:00 PHST- 1972/05/06 00:00 [pubmed] PHST- 1972/05/06 00:01 [medline] PHST- 1972/05/06 00:00 [entrez] AID - 10.1136/bmj.2.5809.311 [doi] PST - ppublish SO - Br Med J. 1972 May 6;2(5809):311-3. doi: 10.1136/bmj.2.5809.311. PMID- 25638996 OWN - NLM STAT- MEDLINE DCOM- 20150716 LR - 20190918 IS - 0042-8450 (Print) IS - 0042-8450 (Linking) VI - 71 IP - 12 DP - 2014 Dec TI - Comparison of efficacy of local hemostatic modalities in anticoagulated patients undergoing tooth extractions. PG - 1097-101 AB - BACKGROUND/AIM: Patients receiving long-term oral anticoagulant therapy pose a clinical challenge during invasive dental procedures. The goal of this study was to compare different local hemostatic modalities after tooth extraction in patients receiving chronic Vitamin-K antagonist therapy. METHODS: Totally 90 patients with International Normalized Ratio (INR) ≤ 3.0 requiring simple extraction of one or two teeth were randomized into three groups, 30 patients in each group. The patients with the mean INR value of 2.35 ± 0.37, in whom extraction wound was sutured comprised the group A. In the group B with the mean INR of 2.43 ± 0.4, local hemostasis was achieved by placing absorbable gelatin sponges into the wound without suturing. The group C consisted of the patients with the mean INR of 2.36 ± 0.34 in whom neither gelatin sponge nor suturing were used for providing local hemostasis. Bleeding was registered as an event if other than initial hemostatic measure was needed or additional oral surgeon intervention required. RESULTS: The obtainded results show that 1 (3.3%) patient in the group A, 2 (6.7%) patients in the groups B and C manifested post-extraction bleeding. All cases of hemorrhage were easily solved with local hemostatic measures and all, except one case, were registered in the first two hours after the procedure until the dismissal. A difference between the groups was not statistically significant (χ2 = .42, p > 0.05). CONCLUSION: In therapeutically anticoagulated patients tooth extractions can be safely performed without altering the dose of anticoagulant medication if efficient local hemostasis is provided. In most cases; in patients with INR ≤ 3.0 after extraction of one or two teeth postoperative bleeding can be controlled with local pressure, without any additional local hemostatic measures. FAU - Bajkin, Branislav V AU - Bajkin BV FAU - Selaković, Srećko D AU - Selaković SD FAU - Mirković, Siniša M AU - Mirković SM FAU - Šarčev, Ivan N AU - Šarčev IN FAU - Tadič, Ana J AU - Tadič AJ FAU - Milekič, Bojana R AU - Milekič BR LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Serbia TA - Vojnosanit Pregl JT - Vojnosanitetski pregled JID - 21530700R RN - 0 (Anticoagulants) SB - IM MH - Administration, Oral MH - Adult MH - Aged MH - Aged, 80 and over MH - Anticoagulants/*administration & dosage MH - Female MH - *Hemostatic Techniques MH - Humans MH - International Normalized Ratio MH - Male MH - Middle Aged MH - Postoperative Hemorrhage/chemically induced/*prevention & control MH - Serbia MH - Surgical Sponges MH - Suture Techniques MH - Tooth Extraction/*methods MH - Treatment Outcome EDAT- 2015/02/03 06:00 MHDA- 2015/07/17 06:00 CRDT- 2015/02/03 06:00 PHST- 2015/02/03 06:00 [entrez] PHST- 2015/02/03 06:00 [pubmed] PHST- 2015/07/17 06:00 [medline] AID - 10.2298/vsp1412097b [doi] PST - ppublish SO - Vojnosanit Pregl. 2014 Dec;71(12):1097-101. doi: 10.2298/vsp1412097b. PMID- 14690657 OWN - NLM STAT- MEDLINE DCOM- 20040224 LR - 20061115 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 33 IP - 1 DP - 2004 Jan TI - Periodontal healing after mandibular third molar surgery--A comparison of distolingual alveolectomy and tooth division techniques. PG - 32-7 AB - The purpose of this study was to compare the periodontal healing of mandibular second molars after the removal of impacted mandibular third molars using distolingual alveolectomy and tooth division techniques. A total of 120 consecutive healthy patients who presented with bilaterally impacted mandibular third molars were included in this study. The same operator removed the impacted third molars on both sides in all patients. The third molar on one side was removed by distolingual alveolectomy using a chisel, whereas the contralateral tooth was removed by the tooth division technique using burs. Attachment level, periodontal pocket depth and bone healing distal to the mandibular second molars were assessed at 7 days, 3 months and 6 months after surgery. The results showed better periodontal healing and bone healing when distolingual alveolectomy was employed, especially in the removal of deeply impacted mandibular third molars. FAU - Chang, H-H AU - Chang HH AD - Department of Dentistry, National Taiwan University Hospital, No 1, Chang-Te Street, Taipei, 100, Taiwan, ROC. FAU - Lee, J-J AU - Lee JJ FAU - Kok, S-H AU - Kok SH FAU - Yang, P-J AU - Yang PJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolectomy MH - Bone Regeneration MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Periodontal Attachment Loss/etiology MH - Periodontal Pocket/etiology MH - Periodontium/pathology/*physiology MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/complications/surgery MH - *Wound Healing EDAT- 2003/12/24 05:00 MHDA- 2004/02/26 05:00 CRDT- 2003/12/24 05:00 PHST- 2003/12/24 05:00 [pubmed] PHST- 2004/02/26 05:00 [medline] PHST- 2003/12/24 05:00 [entrez] AID - S0901-5027(03)90451-6 [pii] AID - 10.1054/ijom.2003.0451 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2004 Jan;33(1):32-7. doi: 10.1054/ijom.2003.0451. PMID- 18420431 OWN - NLM STAT- MEDLINE DCOM- 20080818 LR - 20131121 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 106 IP - 1 DP - 2008 Jul TI - A comparison of the clinical anesthetic efficacy of 4% articaine and 0.5% bupivacaine (both with 1:200,000 epinephrine) for lower third molar removal. PG - 19-28 LID - 10.1016/j.tripleo.2007.11.024 [doi] AB - OBJECTIVE: This study compared the clinical efficacy of 4% articaine (A200) and 0.5% bupivacaine (B200), both with 1:200,000 epinephrine, for lower third molar removal. STUDY DESIGN: Fifty patients underwent removal of symmetrically positioned lower third molars, in 2 separate appointments, under local anesthesia either with A200 or B200, in a double-blind, randomized, and crossover manner. Time to onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, and hemodynamic parameters were evaluated. RESULTS: A statistically significant difference between the time to onset of A200 (1.66 +/- 0.13 minutes) and B200 (2.51 +/- 0.21 minutes) was found (P < .05). There was no statistically significant difference in the duration of analgesia, whether the patient was subjected to osteotomy or not, regardless of the local anesthetic used (3 to 4 hours; P > .05). However, when patients received B200 they experienced a statistically significant longer period of anesthesia on the soft tissues as compared with when they had received A200 (around 5 hours and 4 hours, respectively, P < .05). The surgeon's rating of intraoperative bleeding was considered very close to minimal for both anesthetics. In the surgeries with osteotomy, the comparison between A200 and B200 showed statistically significant differences in the diastolic (64 mm Hg and 68 mm Hg, respectively, P = .001) and mean arterial pressure (86 mm Hg and 89 mm Hg, respectively, P = .031) when data from all the surgical phases were pooled. Additionally, the mouth opening at the suture removal was statistically different for A200 and B200 solutions (91.90% +/- 3.00% and 88.57% +/- 2.38% of the preoperative measure, respectively) when surgeries required bone removal (P < .05). CONCLUSIONS: In comparison with 0.5% bupivacaine, 4% articaine (both with 1:200,000 epinephrine) provided a shorter time to onset and comparable hemostasis and postoperative pain control with a shorter duration of soft tissue anesthesia in lower third molar removal. FAU - Gregorio, Leonardo V L AU - Gregorio LV AD - Bauru School of Dentistry, University of São Paulo, Brazil. FAU - Giglio, Fernando P M AU - Giglio FP FAU - Sakai, Vivien T AU - Sakai VT FAU - Modena, Karin C S AU - Modena KC FAU - Colombini, Bella L AU - Colombini BL FAU - Calvo, Adriana M AU - Calvo AM FAU - Sipert, Carla R AU - Sipert CR FAU - Dionísio, Thiago J AU - Dionísio TJ FAU - Lauris, José R P AU - Lauris JR FAU - Faria, Flávio A C AU - Faria FA FAU - Trindade Junior, Alceu S AU - Trindade Junior AS FAU - Santos, Carlos F AU - Santos CF LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20080416 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anesthetics, Local) RN - D3SQ406G9X (Carticaine) RN - Y8335394RO (Bupivacaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia Recovery Period MH - Anesthesia, Dental/*methods MH - Anesthesia, Local/methods MH - Anesthetics, Local/*administration & dosage MH - Blood Loss, Surgical MH - Blood Pressure/drug effects MH - Bupivacaine/*administration & dosage MH - Carticaine/*administration & dosage MH - Cross-Over Studies MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Osteotomy MH - Pain, Postoperative/prevention & control MH - Tooth Extraction/*methods EDAT- 2008/04/19 09:00 MHDA- 2008/08/19 09:00 CRDT- 2008/04/19 09:00 PHST- 2007/07/31 00:00 [received] PHST- 2007/10/12 00:00 [revised] PHST- 2007/11/21 00:00 [accepted] PHST- 2008/04/19 09:00 [pubmed] PHST- 2008/08/19 09:00 [medline] PHST- 2008/04/19 09:00 [entrez] AID - S1079-2104(07)00871-2 [pii] AID - 10.1016/j.tripleo.2007.11.024 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):19-28. doi: 10.1016/j.tripleo.2007.11.024. Epub 2008 Apr 16. PMID- 26144571 OWN - NLM STAT- MEDLINE DCOM- 20160523 LR - 20181202 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 44 IP - 9 DP - 2015 Sep TI - A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. PG - 1166-74 LID - S0901-5027(15)00230-1 [pii] LID - 10.1016/j.ijom.2015.06.012 [doi] AB - Pain after third molar extraction has been considered the most suitable pharmaceutical model to evaluate acute pain. This study aimed to evaluate the pre-emptive analgesic/anti-inflammatory efficacy of etoricoxib 120 mg following mandibular third molar surgery. A split-mouth, randomized, triple-blind, placebo-controlled study was conducted with patients undergoing the surgical removal of mandibular third molars. All volunteers were allocated randomly to receive either etoricoxib 120 mg or placebo 1h preoperatively, and inflammatory events were evaluated. An estimated sample of 18 surgical units per group was required based on a pilot study (95% confidence level and 80% statistical power). Rescue medication was analyzed by Kaplan-Meier method through log-rank Mantel-Cox test and Pearson linear correlation (P<0.05). Pre-emptive etoricoxib reduced postoperative pain scores significantly in comparison to placebo (P<0.001), with a pain score peak at 6h after surgery (P<0.001). The mean rescue medication consumption was lower in the etoricoxib group compared to the placebo group over the study period (P<0.05). There was no statistically significant difference between groups related to swelling and trismus. The pre-emptive administration of etoricoxib 120 mg significantly reduced the postoperative pain intensity and the need for rescue medication, but did not reduce swelling or trismus. CI - Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Costa, F W G AU - Costa FW AD - Division of Oral Surgery, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: fwildson@yahoo.com.br. FAU - Soares, E C S AU - Soares EC AD - Division of Oral Surgery, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. FAU - Esses, D F S AU - Esses DF AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. FAU - Silva, P G deB AU - Silva PG AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. FAU - Bezerra, T P AU - Bezerra TP AD - Division of Oral Surgery, Walter Cantidio University Hospital, Fortaleza, Ceará, Brazil. FAU - Scarparo, H C AU - Scarparo HC AD - Division of Oral Surgery, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil; Division of Clinical Pharmacology, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. FAU - Ribeiro, T R AU - Ribeiro TR AD - Division of Clinical Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. FAU - Fonteles, C S R AU - Fonteles CS AD - Division of Clinical Pharmacology, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil; Division of Paediatrics, School of Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20150703 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Placebos) RN - 0 (Pyridines) RN - 0 (Sulfones) RN - WRX4NFY03R (Etoricoxib) SB - D SB - IM MH - Adolescent MH - Adult MH - Cyclooxygenase 2 Inhibitors/*therapeutic use MH - Double-Blind Method MH - Etoricoxib MH - Female MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Pyridines/*therapeutic use MH - Sulfones/*therapeutic use MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome OTO - NOTNLM OT - etoricoxib OT - non-steroidal anti-inflammatory drugs OT - pre-emptive analgesia OT - third molar EDAT- 2015/07/07 06:00 MHDA- 2016/05/24 06:00 CRDT- 2015/07/07 06:00 PHST- 2014/08/01 00:00 [received] PHST- 2015/06/04 00:00 [revised] PHST- 2015/06/12 00:00 [accepted] PHST- 2015/07/07 06:00 [entrez] PHST- 2015/07/07 06:00 [pubmed] PHST- 2016/05/24 06:00 [medline] AID - S0901-5027(15)00230-1 [pii] AID - 10.1016/j.ijom.2015.06.012 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2015 Sep;44(9):1166-74. doi: 10.1016/j.ijom.2015.06.012. Epub 2015 Jul 3. PMID- 8870326 OWN - NLM STAT- MEDLINE DCOM- 19961114 LR - 20150901 IS - 0578-1337 (Print) IS - 0578-1337 (Linking) VI - 58 IP - 1 DP - 1996 Jul TI - Premedication with diclofenac and prednisolone to prevent postoperative pain and swelling after third molar removal. PG - 40-4 AB - BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and steroid are able to effectively reduce the postoperative sequelae after impacted third molar removal. However, few studies have evaluated the activity of the combined effects of these two drugs. The purpose of this study was to evaluate whether a single dose of prednisolone, taken orally before operation, would increase the effects of diclofenac in preventing pain and swelling after surgical removal of impacted third molars. METHODS: Thirty healthy patients requiring surgical removal of four third molars were randomly assigned to two groups. In group A, patients were preoperatively given 50 mg of either diclofenac or placebo when impacted teeth were removed on each side. In group B, in addition to 50 mg of diclofenac, 10 mg of prednisolone or placebo was administered. Postoperative pain, swelling and range of mouth opening were recorded. RESULTS: Preoperative administration of 50 mg of diclofenac could relieve pain and swelling more than the placebo. Additional 10 mg of prednisolone could further reduce swelling. CONCLUSIONS: The combination of diclofenac and prednisolone has a better analgesic and anti-inflammatory effect. FAU - Lin, T C AU - Lin TC AD - Department of Dentistry, Veterans General Hospital-Taipe, Taiwan, R.O.C. FAU - Lui, M T AU - Lui MT FAU - Chang, R C AU - Chang RC LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - China (Republic : 1949- ) TA - Zhonghua Yi Xue Za Zhi (Taipei) JT - Zhonghua yi xue za zhi = Chinese medical journal; Free China ed JID - 0005327 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 144O8QL0L1 (Diclofenac) RN - 9PHQ9Y1OLM (Prednisolone) SB - IM MH - Adult MH - Anti-Inflammatory Agents/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third MH - Pain, Postoperative/*prevention & control MH - Prednisolone/*therapeutic use MH - *Premedication MH - *Tooth Extraction EDAT- 1996/07/01 00:00 MHDA- 1996/07/01 00:01 CRDT- 1996/07/01 00:00 PHST- 1996/07/01 00:00 [pubmed] PHST- 1996/07/01 00:01 [medline] PHST- 1996/07/01 00:00 [entrez] PST - ppublish SO - Zhonghua Yi Xue Za Zhi (Taipei). 1996 Jul;58(1):40-4. PMID- 23453611 OWN - NLM STAT- MEDLINE DCOM- 20140220 LR - 20140227 IS - 2212-4411 (Electronic) VI - 116 IP - 1 DP - 2013 Jul TI - Evaluation of postoperative discomfort following third molar surgery using submucosal dexamethasone - a randomized observer blind prospective study. PG - 16-22 LID - S2212-4403(12)01757-9 [pii] LID - 10.1016/j.oooo.2012.12.007 [doi] AB - BACKGROUND: Surgical removal of impacted lower third molar is still the most frequent procedure done by Oral and Maxillofacial surgeons and is often associated with pain, swelling and trismus. These postoperative sequelae can cause distress to the patient as a result of tissue trauma and affect the patient's quality of life after surgery. Use of antiseptic mouthwashes, drains, muscle relaxants, cryotherapy, antibiotics, corticosteroids and physiotherapy seems to decrease postoperative discomfort. Among them corticosteroids are well-known adjuncts to surgery for suppressing tissue mediators of inflammation, thereby reducing transudation of fluids and lessening edema. The rationale of this study is to determine the effectiveness of submucosal injection of dexamethasone in reducing postoperative discomfort after third molar surgery. PATIENTS AND METHODS: 100 patients requiring surgical removal of third molar under local anesthesia were randomly divided into 2 groups, group I receiving 4 mg dexamethasone as submucosal injection and the control group II received no steroid administration. Facial swelling was quantified by anatomical facial landmarks. Furthermore, pain and patient satisfaction, as well as neurological score and the degree of mouth opening were observed from each patient. RESULTS: Patients receiving dexamethasone showed significant reduction in pain, swelling, trismus, a tendency to less neurological complaints and improved quality of life compared with the control group. CONCLUSIONS: Submucosal injection of dexamethasone is more efficient to manage postoperative discomfort after removal of third molars compared to no steroid administration. CI - Copyright © 2013 Elsevier Inc. All rights reserved. FAU - Warraich, Riaz AU - Warraich R AD - Department of Oral and Maxillofacial Surgery, King Edward University, Lahore, Pakistan. FAU - Faisal, Muhammad AU - Faisal M FAU - Rana, Madiha AU - Rana M FAU - Shaheen, Anjum AU - Shaheen A FAU - Gellrich, Nils-Claudius AU - Gellrich NC FAU - Rana, Majeed AU - Rana M LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20130228 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anti-Inflammatory Agents) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM CIN - Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):253. PMID: 24439921 MH - Adult MH - Analysis of Variance MH - Anatomic Landmarks MH - Anti-Inflammatory Agents/*administration & dosage MH - Case-Control Studies MH - Dexamethasone/*administration & dosage MH - Female MH - Humans MH - Injections/methods MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - *Pain Measurement MH - Pain, Postoperative/*diagnosis MH - Patient Satisfaction MH - Prospective Studies MH - Quality of Life MH - Radiography, Panoramic MH - Single-Blind Method MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 2013/03/05 06:00 MHDA- 2014/02/22 06:00 CRDT- 2013/03/05 06:00 PHST- 2012/11/09 00:00 [received] PHST- 2012/12/14 00:00 [accepted] PHST- 2013/03/05 06:00 [entrez] PHST- 2013/03/05 06:00 [pubmed] PHST- 2014/02/22 06:00 [medline] AID - S2212-4403(12)01757-9 [pii] AID - 10.1016/j.oooo.2012.12.007 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jul;116(1):16-22. doi: 10.1016/j.oooo.2012.12.007. Epub 2013 Feb 28. PMID- 22143739 OWN - NLM STAT- MEDLINE DCOM- 20120910 LR - 20190608 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 17 IP - 3 DP - 2012 May 1 TI - Bupivacaine 0.5% versus articaine 4% for the removal of lower third molars. A crossover randomized controlled trial. PG - e462-8 AB - OBJECTIVE: To compare the anesthetic action of 0.5% bupivacaine in relation to 4% articaine, both with 1:200,000 epinephrine, in the surgical removal of lower third molars. As a secondary objective hemodynamic changes using both anesthetics were analyzed. STUDY DESIGN: Triple-blind crossover randomized clinical trial. Eighteen patients underwent bilateral removal of impacted lower third molars using 0.5% bupivacaine or 4% articaine in two different appointments. Preoperative, intraoperative and postoperative variables were recorded. Differences were assessed with McNemar tests and repeated measures ANOVA tests. RESULTS: Both solutions exhibited similar latency times and intraoperative efficacy. Statistical significant lower pain levels were observed with bupivacaine between the fifth (p=0.011) and the ninth (p=0.007) postoperative hours. Bupivacaine provided significantly longer lasting soft tissue anesthesia (p<0.5). Systolic blood pressure and heart rate values were significantly higher with articaine. CONCLUSIONS: Bupivacaine could be a valid alternative to articaine especially due to its early postoperative pain prevention ability. FAU - Sancho-Puchades, Manuel AU - Sancho-Puchades M AD - School of Dentistry, University of Barcelona, Spain. FAU - Vílchez-Pérez, Miguel-Ángel AU - Vílchez-Pérez MÁ FAU - Valmaseda-Castellón, Eduard AU - Valmaseda-Castellón E FAU - Paredes-García, Jordi AU - Paredes-García J FAU - Berini-Aytés, Leonardo AU - Berini-Aytés L FAU - Gay-Escoda, Cosme AU - Gay-Escoda C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20120501 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Anesthetics, Local) RN - D3SQ406G9X (Carticaine) RN - Y8335394RO (Bupivacaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthetics, Local/*administration & dosage MH - Bupivacaine/*administration & dosage MH - Carticaine/*administration & dosage MH - Cross-Over Studies MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - *Tooth Extraction MH - Young Adult PMC - PMC3476102 EDAT- 2011/12/07 06:00 MHDA- 2012/09/11 06:00 CRDT- 2011/12/07 06:00 PHST- 2011/03/28 00:00 [received] PHST- 2011/09/28 00:00 [accepted] PHST- 2011/12/07 06:00 [entrez] PHST- 2011/12/07 06:00 [pubmed] PHST- 2012/09/11 06:00 [medline] AID - 17628 [pii] AID - 10.4317/medoral.17628 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2012 May 1;17(3):e462-8. doi: 10.4317/medoral.17628. PMID- 24481581 OWN - NLM STAT- MEDLINE DCOM- 20151203 LR - 20181023 IS - 1300-0012 (Print) IS - 1300-0012 (Linking) VI - 26 IP - 1 DP - 2014 TI - Preemptive analgesic efficacy of dexketoprofen trometamol on impacted third molar surgery. PG - 29-33 LID - 10.5505/agri.2014.55265 [doi] AB - OBJECTIVE: The aim of this study was to compare the pre-emptive analgesic efficacy of intravenous (IV) dexketoprofen trometamol (DT) and placebo, following impacted mandibular third molar surgery. METHODS: Twenty patients over 18 year old who needed bilateral lower third molar extractions were included in this prospective, randomized and placebo-controlled clinical trial. Patients whom had taken DT 50 mg of before their one extraction, took placebo before their other extraction which had been performed on the opposite side. A total of 40 observations were made. Pain scores were evaluated with a Verbal Rating Scale (VRS) after surgery. Moreover; the time to first analgesic requirement use, additional analgesic need of patients, patient and doctor satisfaction, side effects were also determined. RESULTS: During the first 12 hours, the VRS values in DT group were significantly lower than those of placebo group patients (p<0.05). In placebo group, the time to first analgesic requirement use was significantly earlier than that of patients in DT group (p<0.05). Additional analgesic need of placebo group were significantly greater, when compared with the analgesic need of DT group patients (p<0.05). Among the DT group patients, patient and physician satisfaction was greater, which was statistically significant (p<0.05). CONCLUSION: Preemptive use of IV DT is more effective than placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent removal of an impacted mandibular third molar surgery. FAU - Çağıran, Esra AU - Çağıran E AD - Department of Anaesthesiology and Reanimation, Ege University Faculty of Medicine, İzmir, Turkey. esrayuksel73@yahoo.com. FAU - Eyigör, Can AU - Eyigör C AD - Department of Anaesthesiology and Reanimation, Pain Clinic, Ege University Faculty of Medicine, İzmir, Turkey. FAU - Sezer, Bahar AU - Sezer B AD - Department of Oral and Maxillofacial Surgery, Ege University Faculty of Dentistry, İzmir, Turkey. FAU - Uyar, Meltem AU - Uyar M AD - Department of Anaesthesiology and Reanimation, Pain Clinic, Ege University Faculty of Medicine, İzmir, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Turkey TA - Agri JT - Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology JID - 9426197 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 023C2WHX2V (Tromethamine) RN - 90Y4QC304K (Ketoprofen) RN - N674F7L21E (dexketoprofen trometamol) SB - IM MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Cross-Over Studies MH - Female MH - Humans MH - Ketoprofen/administration & dosage/*analogs & derivatives MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Perioperative Care MH - *Tooth Extraction MH - Treatment Outcome MH - Tromethamine/*administration & dosage MH - Young Adult EDAT- 2014/02/01 06:00 MHDA- 2015/12/15 06:00 CRDT- 2014/02/01 06:00 PHST- 2014/02/01 06:00 [entrez] PHST- 2014/02/01 06:00 [pubmed] PHST- 2015/12/15 06:00 [medline] AID - 10.5505/agri.2014.55265 [doi] PST - ppublish SO - Agri. 2014;26(1):29-33. doi: 10.5505/agri.2014.55265. PMID- 23494455 OWN - NLM STAT- MEDLINE DCOM- 20151005 LR - 20181113 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 18 IP - 1 DP - 2014 Jan TI - Can preoperative imaging help to predict postoperative outcome after wisdom tooth removal? A randomized controlled trial using panoramic radiography versus cone-beam CT. PG - 335-42 LID - 10.1007/s00784-013-0971-x [doi] AB - OBJECTIVES: The primary objective of the study was to compare the postoperative complications following surgical removal of impacted third molars using panoramic radiography (PAN) images- and cone-beam computed tomography (CBCT)-based surgeries for "moderate-risk" cases of impacted third mandibular molars. The secondary objective was to compare the reliability of CBCT with that of PAN in preoperative radiographic determination of the position of the third molar, number of roots, and apical divergence. MATERIALS AND METHODS: A randomized controlled multicenter trial was conducted to compare the surgical complications of PAN- and CBCT-based surgeries of impacted third molars. The sample consisted of impacted third molars from 256 patients with a close relation to the inferior alveolar nerve (IAN). Exclusion criteria were "no risk" and "high risk" of damage to the IAN based on the assessment of the panoramic radiograph. Patients were divided into two groups: the CBCT group (n = 126) and the PAN group (n = 130). The incidences of IAN sensory disturbance and other postoperative complications were recorded for each group at 7 days after surgery. Statistical analysis (kappa values) was used to compare the diagnoses of five trained dentomaxillofacial radiologists and to relate radiologic diagnoses to perioperative findings. Logistic regression was used to determine whether the imaging modality influenced occurrence of postoperative complications. RESULTS: Two extractions (1.5%) in the CBCT group and five (3.8%) in the PAN group resulted in IAN sensory disturbance (p = 0.45). Logistic regression models did not show that CBCT modality decreased postoperative complications following surgical removal of impacted third molars. Yet, CBCT revealed the number of roots and apical divergence of the roots more reliably than panoramic radiographs. CONCLUSIONS: CBCT was not better than panoramic radiography in predicting postoperative complications for moderate-risk cases of impacted third mandibular molars. Nonetheless, a CBCT buccolingual view can accurately confirm the number of roots and root morphology of the third molar better than PAN. CLINICAL RELEVANCE: For management of postoperative complications for moderate-risk cases of impacted mandibular third molars, careful preoperative radiographic planning followed by an atraumatic surgical approach seems to be valuable, irrespective of the 2D or 3D nature of the preoperative images. FAU - Guerrero, Maria Eugenia AU - Guerrero ME AD - Oral Imaging Center, Department of Oral Health Sciences, Faculty of Medicine, University of Leuven, Leuven, Belgium. FAU - Botetano, Raul AU - Botetano R FAU - Beltran, Jorge AU - Beltran J FAU - Horner, Keith AU - Horner K FAU - Jacobs, Reinhilde AU - Jacobs R LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20130315 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - D MH - *Cone-Beam Computed Tomography MH - Humans MH - Molar, Third/*diagnostic imaging/surgery MH - Preoperative Care MH - *Radiography, Panoramic MH - Tooth Extraction/*methods EDAT- 2013/03/16 06:00 MHDA- 2015/10/06 06:00 CRDT- 2013/03/16 06:00 PHST- 2012/05/25 00:00 [received] PHST- 2013/03/04 00:00 [accepted] PHST- 2013/03/16 06:00 [entrez] PHST- 2013/03/16 06:00 [pubmed] PHST- 2015/10/06 06:00 [medline] AID - 10.1007/s00784-013-0971-x [doi] PST - ppublish SO - Clin Oral Investig. 2014 Jan;18(1):335-42. doi: 10.1007/s00784-013-0971-x. Epub 2013 Mar 15. PMID- 20440092 OWN - NLM STAT- MEDLINE DCOM- 20100610 LR - 20181201 IS - 1392-8589 (Print) IS - 1392-8589 (Linking) VI - 12 IP - 1 DP - 2010 TI - The effect of prednisolone on reduction of complaints after impacted third molar removal. PG - 17-22 AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids are able to effectively reduce postoperative sequels after impacted third molar removal. The purpose of this study was to evaluate whether a single dose of prednisolone, taken orally immediately after the operation, would increase the effects of etorikoxib (Arcoxia(R)) NSAID in preventing trismus and swelling after surgical removal of impacted third molars. PATIENTS AND METHODS: This prospective study was conducted in a half-year period on 78 patients who had undergone third molar surgery under local anaesthesia. They were divided into two groups: prednisolone group (38 patients) and control (40 patients). In the prednisolone group 30 mg prednisolone was given to each patient immediately after surgery. Both groups had received Etorikoxib 120 mg 30 minutes before operation. They had to complete a questionnaire evaluating postoperative symptoms. Postoperative pain, facial swelling and trismus were evaluated. RESULTS: Postoperative administration of 30 mg prednisolone to the patients relieved trismus, swelling and pain more than non-administration of prednisolone in the control group. There was significantly less swelling on the first four postoperative days in the prednisolone group compared to control (p<0.05). The values of the maximal interincisal opening (MIO) and visual analogue scale (VAS) were higher for the prednisolone group than for the control group (p<0.05). No clinically apparent infection, disturbance of wound healing, or other corticosteroid-related complications were noted. CONCLUSION: It was found that a combination of a single dose of prednisolone and Etorikoxib is well-suited for treatment of postoperative pain, trismus, and swelling after third molar surgery and should be used to diminish postoperative swelling of soft tissues. FAU - Tiigimae-Saar, Janne AU - Tiigimae-Saar J AD - Department of Maxillofacial Surgery, Tartu University Hospital, Estonia. janne.tiigimae@kliinikum.ee FAU - Leibur, Edvitar AU - Leibur E FAU - Tamme, Tiia AU - Tamme T LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Lithuania TA - Stomatologija JT - Stomatologija JID - 101248498 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Drug Combinations) RN - 0 (Glucocorticoids) RN - 0 (Pyridines) RN - 0 (Sulfones) RN - 9PHQ9Y1OLM (Prednisolone) RN - WRX4NFY03R (Etoricoxib) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Cyclooxygenase 2 Inhibitors/therapeutic use MH - Drug Combinations MH - Edema/prevention & control MH - Etoricoxib MH - Female MH - Glucocorticoids/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Prednisolone/*therapeutic use MH - Premedication MH - Prospective Studies MH - Pyridines/therapeutic use MH - Range of Motion, Articular/drug effects MH - Sulfones/therapeutic use MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Young Adult EDAT- 2010/05/05 06:00 MHDA- 2010/06/11 06:00 CRDT- 2010/05/05 06:00 PHST- 2010/05/05 06:00 [entrez] PHST- 2010/05/05 06:00 [pubmed] PHST- 2010/06/11 06:00 [medline] AID - 101-03 [pii] PST - ppublish SO - Stomatologija. 2010;12(1):17-22. PMID- 11587503 OWN - NLM STAT- MEDLINE DCOM- 20011207 LR - 20190719 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 191 IP - 6 DP - 2001 Sep 22 TI - Pain control with paracetamol from a sustained release formulation and a standard release formulation after third molar surgery: a randomised controlled trial. PG - 319-24 AB - OBJECTIVE: To compare the analgesic efficacy and safety of a sustained release (SR) paracetamol formulation (Panadol Extend) with a standard immediate release (IR) formulation (Panadol) after third molar surgery. DESIGN: A multi-centre, double-blind, randomised clinical trial. METHODS: Patients received either a single oral dose of SR paracetamol or IR paracetamol for pain after the removal of at least one impacted third molar requiring bone removal under general anaesthesia. Post-operative pain and pain relief assessments were undertaken at time intervals up to 8 hours. Global assessments of effectiveness were made at 4 and 8 hours. Any adverse events were also recorded. RESULTS: Of 627 randomised patients, 314 were treated with SR paracetamol and 313 with IR paracetamol. In the per protocol population at 4 hours, 35.1% of the 252 patients on SR paracetamol rated the study medication as very good or excellent compared with 27.7% of the 258 patients on IR paracetamol. There were few statistically significant differences among the secondary parameters but where they did occur they favoured SR paracetamol. Trends in favour of SR paracetamol were observed among the secondary parameters and these tended to emerge at the later time points. For example, while there was no statistically significant difference in time to re-medication between the treatment groups, the estimated time to re-medication was longer for patients treated with SR paracetamol (4 hr 5 min) compared with IR paracetamol (3 hr 10 min). The high rate of re-medication observed is consistent with that reported for IR paracetamol using the post-operative dental pain model(4,6). No difference was observed between the SR paracetamol and IR paracetamol treatment groups in distribution, incidence or severity of adverse events. CONCLUSIONS: SR paracetamol and IR paracetamol are clinically and statistically equivalent. While SR paracetamol and IR paracetamol were similar in terms of both onset of analgesia and peak analgesic effect, SR paracetamol had a longer duration of activity than IR paracetamol. The safety profiles of SR paracetamol and IR paracetamol were found to be very similar. FAU - Coulthard, P AU - Coulthard P AD - Oral and Maxillofacial Surgery, University Dental Hospital of Manchester. paul.coulthard@man.ac.uk FAU - Hill, C M AU - Hill CM FAU - Frame, J W AU - Frame JW FAU - Barry, H AU - Barry H FAU - Ridge, B D AU - Ridge BD FAU - Bacon, T H AU - Bacon TH LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Delayed-Action Preparations) RN - 362O9ITL9D (Acetaminophen) SB - D SB - IM CIN - Br Dent J. 2002 Mar 9;192(5):243; author reply 243. PMID: 11924950 MH - Acetaminophen/*administration & dosage MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/*administration & dosage MH - Delayed-Action Preparations MH - Double-Blind Method MH - Facial Pain/etiology/*prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/etiology/*prevention & control MH - Tooth Extraction/adverse effects EDAT- 2001/10/06 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/10/06 10:00 PHST- 2001/10/06 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/10/06 10:00 [entrez] AID - 10.1038/sj.bdj.4801174 [doi] PST - ppublish SO - Br Dent J. 2001 Sep 22;191(6):319-24. doi: 10.1038/sj.bdj.4801174. PMID- 31490043 OWN - NLM STAT- MEDLINE DCOM- 20200309 LR - 20200309 IS - 2163-0097 (Electronic) IS - 2163-0097 (Linking) VI - 9 IP - 3 DP - 2019 Sep TI - Adjunctive Nd:YAG Laser Irradiation for Ridge Preservation and Immediate Implant Procedures: A Consecutive Case Series. PG - 125-134 LID - 10.1002/cap.10059 [doi] AB - INTRODUCTION: Whether or not laser use provides any meaningful benefit at immediate implant and ridge preservation sites remains an open question in periodontics. However, various lasers have been used in conjunction with tooth extraction and immediate implant placement. Evidence supporting adjunctive laser irradiation at immediate implant and ridge preservation sites is mostly limited to preclinical studies and a small number of case reports. CASE SERIES: Adjunctive neodymium‒doped: yttrium, aluminum, garnet (Nd:YAG) laser irradiation was used at six immediate implant sites and five ridge preservation sites. Three immediate implants were in maxillary incisor positions and three were in premolar positions, two maxillary and one mandibular. All cases exhibited favorable healing and satisfactory clinical outcomes. CONCLUSIONS: Nd:YAG laser energy application with 650-µs pulse duration consistently supported rapid clot formation and graft containment at immediate implant and ridge preservation sites. Histologic analyses and controlled clinical trials comparing ridge preservation and immediate implant procedures with and without laser use are needed. Because cellular responses and clinical outcomes may be exquisitely sensitive to irradiation parameters, studies should report materials and methods in detail. CI - © 2019 American Academy of Periodontology. FAU - Choi, Alicia Y AU - Choi AY AD - Department of Periodontics, Army Postgraduate Dental School, Uniformed Services University of the Health Sciences, Fort Gordon, GA. FAU - Reddy, Caitlin M AU - Reddy CM AD - Department of Periodontics, United States Army Dental Health Activity, Fort Riley, KS. FAU - McGary, Ryan T AU - McGary RT AD - Department of Periodontics, Army Postgraduate Dental School, Uniformed Services University of the Health Sciences, Fort Gordon, GA. FAU - Hill, Richard B AU - Hill RB AD - Department of Periodontics, Army Postgraduate Dental School, Uniformed Services University of the Health Sciences, Fort Gordon, GA. FAU - Swenson, Dane T AU - Swenson DT AD - Department of Periodontics, Army Postgraduate Dental School, Uniformed Services University of the Health Sciences, Fort Gordon, GA. FAU - Seibel, Paul AU - Seibel P AD - Department of Periodontics, United States Army Dental Health Activity, Yongsan, Korea. FAU - Hoag, Justin M AU - Hoag JM AD - Department of Periodontics, United States Army Dental Health Activity, Fort Drum, NY. FAU - Berridge, Joshua P AU - Berridge JP AD - Department of Periodontics, United States Army Dental Health Activity, Fort Bragg, NC. FAU - Johnson, Thomas M AU - Johnson TM AD - Department of Periodontics, Army Postgraduate Dental School, Uniformed Services University of the Health Sciences, Fort Gordon, GA. LA - eng PT - Case Reports PT - Journal Article DEP - 20190410 PL - United States TA - Clin Adv Periodontics JT - Clinical advances in periodontics JID - 101597440 RN - 0 (Dental Implants) SB - D SB - IM MH - *Dental Implants MH - Humans MH - *Laser Therapy MH - Lasers, Solid-State MH - Maxilla MH - *Tooth Extraction/methods MH - Tooth Socket OTO - NOTNLM OT - *Allografts OT - *cone‐beam computed tomography OT - *dental implants OT - *hemostasis OT - *lasers OT - *tooth extraction EDAT- 2019/09/07 06:00 MHDA- 2020/03/10 06:00 CRDT- 2019/09/07 06:00 PHST- 2018/09/13 00:00 [received] PHST- 2019/02/16 00:00 [accepted] PHST- 2019/09/07 06:00 [entrez] PHST- 2019/09/07 06:00 [pubmed] PHST- 2020/03/10 06:00 [medline] AID - 10.1002/cap.10059 [doi] PST - ppublish SO - Clin Adv Periodontics. 2019 Sep;9(3):125-134. doi: 10.1002/cap.10059. Epub 2019 Apr 10. PMID- 19484402 OWN - NLM STAT- MEDLINE DCOM- 20101216 LR - 20181113 IS - 1435-604X (Electronic) IS - 0268-8921 (Linking) VI - 25 IP - 5 DP - 2010 Sep TI - Placebo-controlled randomized clinical trial of the effect two different low-level laser therapies (LLLT)--intraoral and extraoral--on trismus and facial swelling following surgical extraction of the lower third molar. PG - 641-5 LID - 10.1007/s10103-009-0684-1 [doi] AB - The purpose of this study is to compare the effects of extraoral and intraoral low-level laser therapies (LLLT) on postoperative trismus and oedema following the removal of mandibular third molars. Forty-eight patients who were to undergo surgical removal of their lower third molars were studied. Patients were randomly allocated to one of three groups: extraoral LLLT, intraoral LLLT, or placebo. In the study, a Ga-Al-As diode laser device with a continuous wavelength of 808 nm was used, and the laser therapy was applied by using a 1 x 3-cm handpiece. The flat-top laser beam profile was used in this therapy. For both of the LLLT groups, laser energy was applied at 100 mW (0.1 W) for a total of 120 s (0.1 W x 120 s = 12 J). Patients in the extraoral-LLLT group (n = 16) received 12-J (4 J/cm(2)) low-level laser irradiation, and the laser was applied at the insertion point of the masseter muscle immediately after the operation. Patients in the intraoral-LLLT group (n = 16) received 12-J (4 J/cm(2)) low-level laser irradiation intraorally at the operation site 1 cm from the target tissue. In the placebo group (n = 16), the handpiece was inserted intraorally at the operation site and then was touched extraorally to the masseter muscle for 1 min at each site (120 s total), but the laser was not activated. The size of the interincisal opening and facial swelling were evaluated on the second and seventh postoperative days. At the second postoperative day, trismus (29.0 +/- 7.6 mm [p = 0.010]) and swelling (105.3 +/- 5.0 mm [p = 0.047]) in the extraoral-LLLT group were significantly less than in the placebo group (trismus: 21.1 +/- 7.6 mm, swelling: 109.1 +/- 4.4 mm). Trismus (39.6 +/- 9.0 mm [p = 0.002]) in the extraoral-LLLT group at the seventh postoperative day was also significantly less than in the placebo group (29.0 +/- 6.2 mm). However, at the seventh postoperative day in the intraoral-LLLT group, only trismus (35.6 +/- 8.5 [p = 0.002]) was significantly less than in the placebo group (29.0 +/- 6.2 mm). This study demonstrates that extraoral LLLT is more effective than intraoral LLLT for the reduction of postoperative trismus and swelling after extraction of the lower third molar. FAU - Aras, Mutan Hamdi AU - Aras MH AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Gaziantep University, Gaziantep, Turkey. mutanhamdi@hotmail.com FAU - Güngörmüş, Metin AU - Güngörmüş M LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20090531 PL - England TA - Lasers Med Sci JT - Lasers in medical science JID - 8611515 SB - IM MH - Adolescent MH - Adult MH - Edema/*prevention & control MH - Female MH - Humans MH - Lasers, Semiconductor/therapeutic use MH - Low-Level Light Therapy/*methods MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Postoperative Complications/prevention & control MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/*prevention & control MH - Young Adult EDAT- 2009/06/02 09:00 MHDA- 2010/12/17 06:00 CRDT- 2009/06/02 09:00 PHST- 2008/05/20 00:00 [received] PHST- 2009/05/12 00:00 [accepted] PHST- 2009/06/02 09:00 [entrez] PHST- 2009/06/02 09:00 [pubmed] PHST- 2010/12/17 06:00 [medline] AID - 10.1007/s10103-009-0684-1 [doi] PST - ppublish SO - Lasers Med Sci. 2010 Sep;25(5):641-5. doi: 10.1007/s10103-009-0684-1. Epub 2009 May 31. PMID- 3863913 OWN - NLM STAT- MEDLINE DCOM- 19851125 LR - 20061115 IS - 0022-3492 (Print) IS - 0022-3492 (Linking) VI - 56 IP - 10 DP - 1985 Oct TI - Surgical removal of the fully impacted mandibular third molar. The influence of flap design and alveolar bone height on the periodontal status of the second molar. PG - 625-30 AB - This study was carried out because a great deal of uncertainty exists as to he effect of the surgical removal of the fully impacted third molar on the periodontal status of the second molar. The objectives were to determine the effect of surgical removal of the third molar on the periodontal status of the second molar; the influence of flap design on these results; the influence of the initial height of the alveolar bone on the distal of the second molar on subsequent changes in attachment level. The study included 30 patients with bilateral mandibular impactions. A split-mouth experimental design was used, with one side of the mandible being randomly allocated to one of two flap design groups. Plaque level, gingival inflammation, probing depth and attachment level measurements around the second molar were taken at baseline and then at monthly intervals for a period of 6 months. Alveolar bone height was measured from panoramic radiographs. Six months postsurgically, both flap design groups exhibited a statistically significant loss of attachment level on the distal surface of the second molar with no difference between the two flap groups. The initial height of the alveolar bone on the distal of the second molar had no influence on the loss of attachment. It was concluded that the surgical removal of the fully impacted mandibular third molar led to the loss of attachment on the distal of the second molar; flap design had no influence on the degree of attachment loss; the initial height of the alveolar bone on the distal of the second molar had no influence on the loss of attachment. FAU - Quee, T A AU - Quee TA FAU - Gosselin, D AU - Gosselin D FAU - Millar, E P AU - Millar EP FAU - Stamm, J W AU - Stamm JW LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolar Process/*anatomy & histology MH - Dental Plaque/pathology MH - Epithelial Attachment/anatomy & histology MH - Female MH - Gingivitis/pathology MH - Humans MH - Male MH - Mandible MH - Molar/*anatomy & histology MH - Molar, Third/*surgery MH - Periodontal Diseases/*etiology MH - *Surgical Flaps MH - Tooth, Impacted/*surgery EDAT- 1985/10/01 00:00 MHDA- 1985/10/01 00:01 CRDT- 1985/10/01 00:00 PHST- 1985/10/01 00:00 [pubmed] PHST- 1985/10/01 00:01 [medline] PHST- 1985/10/01 00:00 [entrez] AID - 10.1902/jop.1985.56.10.625 [doi] PST - ppublish SO - J Periodontol. 1985 Oct;56(10):625-30. doi: 10.1902/jop.1985.56.10.625. PMID- 20596067 OWN - NLM STAT- MEDLINE DCOM- 20101019 LR - 20101129 IS - 1476-5373 (Electronic) IS - 0007-0610 (Linking) VI - 209 IP - 1 DP - 2010 Jul 10 TI - Experience in third molar surgery: an update. PG - E1 LID - 10.1038/sj.bdj.2010.581 [doi] AB - BACKGROUND: The relationship between a surgeon's experience and the incidence of postoperative complications after third molar surgery is assessed in this prospective clinical study. Previous reports have shown this to be one the most influential factors on surgical outcome. METHOD: In this study, 3,236 patients underwent surgical removal of impacted third molars. All patients included in the study were reviewed and the various postoperative complications were recorded and statistically compared to the surgeon's grade. Patients' demographics and pre-operative radiographic findings were also noted. RESULTS: The surgical procedures were performed by seven specialists and 12 residents. In the group of patients treated by the residents, the incidence of postoperative complications was found to be significant with regards to trismus, infection, alveolar osteitis and paraesthesia of the lingual and inferior alveolar nerves. In the group of patients treated by specialists, the incidence of postoperative bleeding was found to be statistically significant. CONCLUSION: There is without doubt a relationship between the surgeon's experience and the postoperative complication in third molar surgery. The impact of the findings from this study upon the profession, education and research is as yet unrealised. The ethical and moral implications of our findings are discussed. FAU - Jerjes, W AU - Jerjes W AD - UCLH Head and Neck Centre, 250 Euston Road, London, NW1 2PG. waseem_wk1@yahoo.co.uk FAU - Upile, T AU - Upile T FAU - Nhembe, F AU - Nhembe F FAU - Gudka, D AU - Gudka D FAU - Shah, P AU - Shah P FAU - Abbas, S AU - Abbas S FAU - McCarthy, E AU - McCarthy E FAU - Patel, S AU - Patel S FAU - Mahil, J AU - Mahil J FAU - Hopper, C AU - Hopper C LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20100702 PL - England TA - Br Dent J JT - British dental journal JID - 7513219 SB - D SB - IM CIN - Br Dent J. 2010 Jul 10;209(1):36-7. PMID: 20616839 CIN - Br Dent J. 2010 Nov;209(9):423-4. PMID: 21072071 MH - Adolescent MH - Adult MH - Chi-Square Distribution MH - *Clinical Competence MH - Female MH - Humans MH - Internship and Residency MH - Likelihood Functions MH - London MH - Male MH - Molar, Third/*surgery MH - *Postoperative Complications MH - Prospective Studies MH - Surgery, Oral MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2010/07/03 06:00 MHDA- 2010/10/20 06:00 CRDT- 2010/07/03 06:00 PHST- 2010/03/26 00:00 [accepted] PHST- 2010/07/03 06:00 [entrez] PHST- 2010/07/03 06:00 [pubmed] PHST- 2010/10/20 06:00 [medline] AID - sj.bdj.2010.581 [pii] AID - 10.1038/sj.bdj.2010.581 [doi] PST - ppublish SO - Br Dent J. 2010 Jul 10;209(1):E1. doi: 10.1038/sj.bdj.2010.581. Epub 2010 Jul 2. PMID- 24315312 OWN - NLM STAT- MEDLINE DCOM- 20140509 LR - 20140217 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 72 IP - 3 DP - 2014 Mar TI - Is thermography useful for assessment of postoperative inflammation after surgical removal of mandibular third molars when methylprednisolone is administered and how does it correlate with patients' perception of swelling? PG - 463-9 LID - S0278-2391(13)01227-5 [pii] LID - 10.1016/j.joms.2013.09.035 [doi] AB - PURPOSE: To assess the differences in facial skin temperature after mandibular third molar removal when patients received methylprednisolone and placebo, respectively and to assess the correlation between patient-reported swelling using a visual analog scale (VAS) and facial skin temperature measured using thermography. PATIENTS AND METHODS: The study involved patients with 2 mandibular third molars with an indication for removal. The patients received either methylprednisolone or placebo in a randomized, crossover study design. Thermograms and the swelling VAS score were recorded 2 days after surgery. The outcome variable was the temperature difference (Δt) between the operated and control sides. A 2-sample t test analyzed the difference in Δt between the first and second operations. Spearman's rank correlation analysis was used to assess the correlation between the swelling VAS scores and the Δt. RESULTS: A total of 124 patients (67 males, 57 females, mean age 25 years) had both mandibular third molars removed on 2 separate occasions. No difference in Δt was found when methylprednisolone and placebo were given (P = .07). In addition, the correlation between the swelling VAS score and Δt was 0.30 (P = .001) and 0.09 (P = .3) after the first and second operation, respectively. CONCLUSIONS: Thermography does not seem sensitive enough to detect differences in the inflammatory response when patients received methylprednisolone or placebo. The correlation between the Δt and patient-reported swelling was low (≤0.3). CI - Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Christensen, Jennifer AU - Christensen J AD - PhD Student, Section for Oral Radiology and Section for Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus University Graduate School of Health, Aarhus, Denmark. Electronic address: jennifer.heather.christensen@odontologi.au.dk. FAU - Matzen, Louise Hauge AU - Matzen LH AD - Research Assistant, Section for Oral Radiology and Section for Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus, Denmark. FAU - Schou, Søren AU - Schou S AD - Professor, Section for Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus University Graduate School of Health, Aarhus, Denmark. FAU - Væth, Michael AU - Væth M AD - Professor, Section for Biostatistics, Department of Public Health, Aarhus University Graduate School of Health, Aarhus, Denmark. FAU - Wenzel, Ann AU - Wenzel A AD - Professor, Section for Oral Radiology, Department of Dentistry, Aarhus University Graduate School of Health, Aarhus, Denmark. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20131005 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents) RN - X4W7ZR7023 (Methylprednisolone) SB - AIM SB - D SB - IM MH - Adult MH - Anti-Inflammatory Agents/*therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Edema/prevention & control/psychology MH - Face MH - Female MH - Humans MH - Image Processing, Computer-Assisted MH - Inflammation/*diagnosis/etiology/prevention & control/psychology MH - Male MH - Methylprednisolone/*therapeutic use MH - Molar, Third/surgery MH - Patient Satisfaction MH - Postoperative Complications/diagnosis/prevention & control/*psychology MH - *Skin Temperature MH - Statistics, Nonparametric MH - *Thermography MH - *Tooth Extraction MH - Visual Analog Scale EDAT- 2013/12/10 06:00 MHDA- 2014/05/10 06:00 CRDT- 2013/12/10 06:00 PHST- 2013/07/22 00:00 [received] PHST- 2013/09/26 00:00 [revised] PHST- 2013/09/29 00:00 [accepted] PHST- 2013/12/10 06:00 [entrez] PHST- 2013/12/10 06:00 [pubmed] PHST- 2014/05/10 06:00 [medline] AID - S0278-2391(13)01227-5 [pii] AID - 10.1016/j.joms.2013.09.035 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2014 Mar;72(3):463-9. doi: 10.1016/j.joms.2013.09.035. Epub 2013 Oct 5. PMID- 25442243 OWN - NLM STAT- MEDLINE DCOM- 20150714 LR - 20141208 IS - 2212-4411 (Electronic) VI - 119 IP - 1 DP - 2015 Jan TI - Amoxicillin/clavulanic acid 2000/125 mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial. PG - 8-16 LID - S2212-4403(14)01238-3 [pii] LID - 10.1016/j.oooo.2014.08.014 [doi] AB - OBJECTIVE: The purpose of this study was to determine the effect of amoxicillin/clavulanic acid to prevent infection following completely bone-impacted lower third molar removal. STUDY DESIGN: A random, double-blind placebo-controlled clinical trial including 118 adults randomly allocated to placebo (60 patients) or antibiotic treatment (58 patients): 2 g amoxicillin/125 mg clavulanic acid 2 hours before the surgery and post-operatively twice a day for 4 days. Infection was clinically assessed until 8 weeks after surgery. Adverse events, as well as clinical and surgical variables, were recorded. Analysis was by intention to treat. RESULTS: Infections developed in five patients in the placebo group, all in the first postoperative week, and in two in the antibiotic group, both after the first week, the difference not being statistically significant (P = .278, number needed to treat 19 [8-∞]). There were no relationships between any variables studied and infection. No serious adverse events were reported. CONCLUSION: There is insufficient evidence to recommend routine use of this antibiotic treatment. CI - Copyright © 2015 Elsevier Inc. All rights reserved. FAU - Arteagoitia, Iciar AU - Arteagoitia I AD - Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain. FAU - Ramos, Eva AU - Ramos E AD - College of Pharmacists, Vizcaya, Spain. FAU - Santamaria, Gorka AU - Santamaria G AD - Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain. FAU - Barbier, Luis AU - Barbier L AD - Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain; Maxillofacial Group, BioCruces Health Research Institute, Cruces University Hospital, Vizcaya, Spain. FAU - Alvarez, Julio AU - Alvarez J AD - Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain; Maxillofacial Group, BioCruces Health Research Institute, Cruces University Hospital, Vizcaya, Spain. FAU - Santamaria, Joseba AU - Santamaria J AD - Stomatology I Department, Research group UPV/EHU IT821-13, University of the Basque Country, Leioa, Bizkaia, Spain; Maxillofacial Group, BioCruces Health Research Institute, Cruces University Hospital, Vizcaya, Spain. Electronic address: Jsz@clinicaimd.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140916 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anti-Bacterial Agents) RN - 0 (Placebos) RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) SB - D SB - IM MH - Adult MH - Amoxicillin-Potassium Clavulanate Combination/*therapeutic use MH - Anti-Bacterial Agents/*therapeutic use MH - Antibiotic Prophylaxis MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Placebos MH - Postoperative Care MH - Surgical Wound Infection/*prevention & control MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2014/12/03 06:00 MHDA- 2015/07/15 06:00 CRDT- 2014/12/03 06:00 PHST- 2014/05/19 00:00 [received] PHST- 2014/08/05 00:00 [revised] PHST- 2014/08/25 00:00 [accepted] PHST- 2014/12/03 06:00 [entrez] PHST- 2014/12/03 06:00 [pubmed] PHST- 2015/07/15 06:00 [medline] AID - S2212-4403(14)01238-3 [pii] AID - 10.1016/j.oooo.2014.08.014 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jan;119(1):8-16. doi: 10.1016/j.oooo.2014.08.014. Epub 2014 Sep 16. PMID- 24985959 OWN - NLM STAT- MEDLINE DCOM- 20140930 LR - 20171116 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 72 IP - 9 DP - 2014 Sep TI - Can ambient orange fragrance reduce patient anxiety during surgical removal of impacted mandibular third molars? PG - 1671-6 LID - S0278-2391(14)00367-X [pii] LID - 10.1016/j.joms.2014.03.031 [doi] AB - PURPOSE: To investigate whether ambient orange fragrance, compared with no fragrance, can reduce patient anxiety before and during surgical removal of an impacted mandibular third molar. MATERIALS AND METHODS: In the present randomized clinical trial, the patients who required extraction of an impacted mandibular third molar and fulfilled the predetermined criteria were included. A dental anxiety scale (DAS) questionnaire was used to determine the anxiety level of the patients before surgery. Only patients with moderate and high anxiety levels (DAS scale ≥ 9 to ≤ 14) were included. The predictor variable was fragrance exposure. The fragrance group was exposed to orange fragrance, and the control group was exposed to no fragrance. The outcome variables were physiologic measures related to anxiety, including the mean blood pressure, respiratory rate, and pulse rate. The physiologic vital changes were determined before and during the surgical procedure. The data were analyzed using the independent t test, χ(2) test, and Mann-Whitney U test (Statistical Package for Social Sciences, version 16; α = 0.05). RESULTS: A total of 56 patients fulfilled the inclusion criteria (fragrance group, 19 males and 9 females; no-fragrance group, 12 males and 16 females). Before entering the waiting room, the patients' vital signs were recorded twice. No significant differences were found between the 2 groups. The mean blood pressure, pulse rate, and respiratory rate were significantly lower in the fragrance group during surgery (from sitting in the dental chair to the end of surgery; P < .05). CONCLUSIONS: The results of our study have shown that orange fragrance is effective in reducing the anxiety related to surgical removal of an impacted mandibular third molar. CI - Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved. FAU - Hasheminia, Dariush AU - Hasheminia D AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Torabinejad Dental Research Center, Isfahan University of Medical Sciences School of Dentistry, Isfahan, Iran. FAU - Kalantar Motamedi, Mahmood Reza AU - Kalantar Motamedi MR AD - Dental Student, Dental Students Research Center, Isfahan University of Medical Sciences, School of Dentistry, Isfahan, Iran. FAU - Karimi Ahmadabadi, Fatemeh AU - Karimi Ahmadabadi F AD - General Dentist, Private Office, Isfahan, Iran. FAU - Hashemzehi, Hadi AU - Hashemzehi H AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Zahedan University of Medical Sciences, School of Dentistry, Zahedan, Iran. FAU - Haghighat, Abbas AU - Haghighat A AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Torabinejad Dental Research Center, Isfahan University of Medical Sciences, School of Dentistry, Isfahan, Iran. Electronic address: haghighat@dnt.mui.ac.ir. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20140412 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Placebos) RN - 0 (Plant Oils) RN - AKN3KSD11B (orange oil) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Blood Pressure/physiology MH - *Citrus aurantiifolia MH - Dental Anxiety/*prevention & control MH - Educational Status MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Placebos MH - Plant Oils/*therapeutic use MH - Prospective Studies MH - Pulse MH - Respiration MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Vital Signs MH - Young Adult EDAT- 2014/07/06 06:00 MHDA- 2014/10/01 06:00 CRDT- 2014/07/03 06:00 PHST- 2014/01/26 00:00 [received] PHST- 2014/03/20 00:00 [revised] PHST- 2014/03/27 00:00 [accepted] PHST- 2014/07/03 06:00 [entrez] PHST- 2014/07/06 06:00 [pubmed] PHST- 2014/10/01 06:00 [medline] AID - S0278-2391(14)00367-X [pii] AID - 10.1016/j.joms.2014.03.031 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2014 Sep;72(9):1671-6. doi: 10.1016/j.joms.2014.03.031. Epub 2014 Apr 12. PMID- 26640405 OWN - NLM STAT- MEDLINE DCOM- 20160927 LR - 20181202 IS - 1449-1907 (Electronic) IS - 1449-1907 (Linking) VI - 12 IP - 11 DP - 2015 TI - The Effectiveness of Ropivacaine and Mepivacaine in the Postoperative Pain after Third Lower Molar Surgery. PG - 862-6 LID - 10.7150/ijms.13072 [doi] AB - AIM: To compare the efficacy of 0.75% ropivacaine with 3% mepivacaine for pain control in the first 24 hours after surgical removal of lower third molars, using a quantitative measurement such as VAS. The secondary objective involved rescue analgesia. METHODS: Forty-five patients, 21 females and 24 males, mean age 23,2 ± 3 years, underwent surgical removal of third molars in two separate sessions. A split-mouth design was chosen, so each patient underwent both the first and second surgeries, having for each extraction a different anesthetic. The second extraction was carried out 1 month later. Parameters evaluated were: onset of anesthesia, duration of surgery, lip numbness, timing of pain appearance and first analgesic intake. RESULTS: No significant differences about onset of anesthesia, duration of surgical procedures, and timing of first analgesic intake were found. Lower lip numbness, on the other hand, was more prolonged after using ropivacaine (p < 0.0001) and the onset of postoperative pain was more delayed after anesthesia with ropivacaine (p=0.0048). Pain scores at 1 and 2 hours after surgery were 3.5 ± 2.0 and 4.1 ± 1.3 after injection of mepivacaine, and 2.7 ± 2.2 and 2.9 ± 2.4 after ropivacaine (p value =0.006 for both time points). No significant differences in pain score were recorded between the two anesthetics at 12 and 24 hours post surgery. CONCLUSIONS: With the use of ropivacaine, the discomfort caused by prolonged lip numbness is counterbalanced by less postoperative discomfort after surgery. In addition, when compared with other long-acting anesthetics, ropivacaine ensures a safer anesthetic profile for medically complex patients. FAU - Crincoli, Vito AU - Crincoli V AD - 1. Interdisciplinary Department of Medicine, University of Bari, Italy. FAU - Favia, Gianfranco AU - Favia G AD - 1. Interdisciplinary Department of Medicine, University of Bari, Italy. FAU - LImongelli, Luisa AU - LImongelli L AD - 1. Interdisciplinary Department of Medicine, University of Bari, Italy. FAU - Tempesta, Angela AU - Tempesta A AD - 1. Interdisciplinary Department of Medicine, University of Bari, Italy. FAU - Brienza, Nicola AU - Brienza N AD - 2. Anesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Italy. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20151016 TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 0 (Amides) RN - 0 (Anesthetics, Local) RN - 7IO5LYA57N (Ropivacaine) RN - B6E06QE59J (Mepivacaine) SB - IM MH - Adult MH - Amides/*therapeutic use MH - Anesthetics, Local/*therapeutic use MH - Female MH - Humans MH - Male MH - Mepivacaine/*therapeutic use MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Prospective Studies MH - Ropivacaine PMC - PMC4643076 OTO - NOTNLM OT - local anesthetics OT - postoperative pain. OT - third molar surgery COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2015/12/08 06:00 MHDA- 2016/09/28 06:00 CRDT- 2015/12/08 06:00 PHST- 2015/06/28 00:00 [received] PHST- 2015/09/20 00:00 [accepted] PHST- 2015/12/08 06:00 [entrez] PHST- 2015/12/08 06:00 [pubmed] PHST- 2016/09/28 06:00 [medline] AID - ijmsv12p0862 [pii] AID - 10.7150/ijms.13072 [doi] PST - epublish SO - Int J Med Sci. 2015 Oct 16;12(11):862-6. doi: 10.7150/ijms.13072. eCollection 2015. PMID- 25938155 OWN - NLM STAT- MEDLINE DCOM- 20151114 LR - 20181202 IS - 1006-7248 (Print) IS - 1006-7248 (Linking) VI - 24 IP - 2 DP - 2015 Apr TI - [Comparison of two different flap designs in removal of impacted wisdom tooth]. PG - 224-7 AB - PURPOSE: The purpose of this study was to compare the effect of two different flap designs on surgical removal of impacted mandibular third molars. METHODS: Four hundred patients who required removal of impacted mandibular third molars were included in the study. They were divided into group A and group B randomly. Patients in group A received distal incision flap and group B underwent angular incision flap. The effect of flap design on surgical time, incidence of dry socket, pain, swelling and trismus was evaluated postoperatively. Data analysis was carried out with SPSS 13.0 software package. RESULTS: The surgical time was longer in group A than in group B 3 days postoperatively. Facial swelling and trismus were less in group A than in group B 3 days postoperatively. There was no significant difference in two groups 7 days postoperatively. CONCLUSIONS: The distal incision flap design can release facial swelling and trismus in surgical removal of impacted mandibular third molars. FAU - He, Jin-quan AU - He JQ AD - Zhujiang Hospital of Souhern Medical University,Guangzhou 510280;China.Guangdong Province, China.E-mail:345782683@qq.com. FAU - Ouyang, Ke-xiong AU - Ouyang KX FAU - Zhang, Qing-bin AU - Zhang QB FAU - Zhou, Miao AU - Zhou M FAU - Yang, Zi-nan AU - Yang ZN FAU - Piao, Zheng-guo AU - Piao ZG LA - chi PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - China TA - Shanghai Kou Qiang Yi Xue JT - Shanghai kou qiang yi xue = Shanghai journal of stomatology JID - 101090220 SB - D SB - IM MH - Dry Socket MH - Edema MH - Humans MH - Mandible MH - *Molar, Third MH - Pain, Postoperative MH - *Surgical Flaps MH - *Tooth Extraction MH - *Tooth, Impacted MH - *Treatment Outcome MH - Trismus EDAT- 2015/05/06 06:00 MHDA- 2015/11/15 06:00 CRDT- 2015/05/05 06:00 PHST- 2015/05/05 06:00 [entrez] PHST- 2015/05/06 06:00 [pubmed] PHST- 2015/11/15 06:00 [medline] PST - ppublish SO - Shanghai Kou Qiang Yi Xue. 2015 Apr;24(2):224-7. PMID- 21802823 OWN - NLM STAT- MEDLINE DCOM- 20120117 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 12 DP - 2011 Dec TI - Bleeding evaluation during single tooth extraction in patients with coronary artery disease and acetylsalicylic acid therapy suspension: a prospective, double-blinded, and randomized study. PG - 2949-55 LID - 10.1016/j.joms.2011.02.139 [doi] AB - PURPOSE: Acetylsalicylic acid (ASA) has been used for the primary and secondary prevention of cardiovascular events. To reduce bleeding, the administration of ASA has traditionally been suspended before dental procedures; however, this suspension potentially increases the risk of thromboembolic events. The effect of ASA on the amount of bleeding that occurs during tooth extraction procedures is controversial, and perioperative guidelines recommend that ASA administration should not be altered for such procedures. The aim of this study was to evaluate the amount of bleeding that occurs during the intraoperative period of tooth extraction procedures in patients with coronary artery disease who are either undergoing acetylsalicylic acid (ASA) therapy or who have been instructed to suspend their ASA use. PATIENTS AND METHODS: Sixty-three patients with coronary artery disease who required tooth extraction were enrolled in this study. All patients were receiving 100 mg/d of ASA at the time of enrollment and were randomly placed into 2 groups: group S, which was comprised of patients whose ASA therapy was suspended 7 days before tooth extraction, and group NS, comprised of patients whose ASA therapy was unaltered. A platelet aggregation test was carried out on the day of the operation, and the amount of bleeding was measured during the intraoperative period by means of aspirated blood collection. All the extractions were performed by the same surgeon, who was unaware of whether the patient's ASA therapy had been suspended. RESULTS: The mean (± SD) volume of bleeding was 12.10 ± 9.37 mL for patients who underwent ASA therapy suspension and 16.38 ± 13.54 mL for those patients whose treatments were unaltered (P = .151). Local hemostatic methods were sufficient to control bleeding, and there were no reported episodes of hemorrhaging during the intra- and postoperative periods. The platelet reactivity index values exhibited statistically significant differences between the 2 investigated groups (P = .004). The platelet reactivity index values for group S and group NS were 242.58 ± 71.26 and 192.09 ± 60.54, respectively. CONCLUSION: There was no difference in the amount of bleeding that occurred during tooth extraction between patients who continued ASA therapy versus patients who suspended their ASA therapy. The platelet reactivity test demonstrated a reduction in platelet aggregation in the ASA therapy group (group NS), but this reduction was without clinical consequence. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Medeiros, Frederico Buhatem AU - Medeiros FB AD - Department of Dentistry, Sociedade Paulista de Cardiologia do Estado São Paulo, Brazil. fredericobuhatem@yahoo.com.br FAU - de Andrade, Ana Carolina Porrio AU - de Andrade AC FAU - Angelis, Gabriella A M C AU - Angelis GA FAU - Conrado, Valéria C L S AU - Conrado VC FAU - Timerman, Lilia AU - Timerman L FAU - Farsky, Pedro AU - Farsky P FAU - Dib, Luciano Lauria AU - Dib LL LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20110729 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Platelet Aggregation Inhibitors) RN - R16CO5Y76E (Aspirin) SB - AIM SB - D SB - IM CIN - Evid Based Dent. 2012;13(3):89-90. PMID: 23059927 MH - Adult MH - Aged MH - Aged, 80 and over MH - Aspirin/*administration & dosage MH - *Blood Loss, Surgical/prevention & control MH - Chi-Square Distribution MH - Coronary Disease/*drug therapy MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - Platelet Aggregation/drug effects MH - Platelet Aggregation Inhibitors/*administration & dosage MH - Platelet Function Tests MH - Practice Guidelines as Topic MH - Prospective Studies MH - Statistics, Nonparametric MH - Thromboembolism/prevention & control MH - *Tooth Extraction EDAT- 2011/08/02 06:00 MHDA- 2012/01/18 06:00 CRDT- 2011/08/02 06:00 PHST- 2010/09/12 00:00 [received] PHST- 2011/02/19 00:00 [revised] PHST- 2011/02/24 00:00 [accepted] PHST- 2011/08/02 06:00 [entrez] PHST- 2011/08/02 06:00 [pubmed] PHST- 2012/01/18 06:00 [medline] AID - S0278-2391(11)00413-7 [pii] AID - 10.1016/j.joms.2011.02.139 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Dec;69(12):2949-55. doi: 10.1016/j.joms.2011.02.139. Epub 2011 Jul 29. PMID- 23010375 OWN - NLM STAT- MEDLINE DCOM- 20130211 LR - 20191210 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 71 IP - 1 DP - 2013 Jan TI - Predicting third molar surgery operative time: a validated model. PG - 5-13 LID - S0278-2391(12)01147-0 [pii] LID - 10.1016/j.joms.2012.08.004 [doi] AB - PURPOSE: The purpose of the present study was to develop and validate a statistical model to predict third molar (M3) operative time. MATERIALS AND METHODS: This was a prospective cohort study consisting of a sample of subjects presenting for M3 removal. The demographic, anatomic, and operative variables were recorded for each subject. Using an index sample of randomly selected subjects, a multiple linear regression model was generated to predict the operating time. A nonoverlapping group of randomly selected subjects (validation sample) was used to assess model accuracy. P≤.05 was considered significant. RESULTS: The sample was composed of 150 subjects (n) who had 450 (k) M3s removed. The index sample (n=100 subjects, k=313 M3s extracted) had a mean age of 25.4±10.0 years. The mean extraction time was 6.4±7.0 minutes. The multiple linear regression model included M3 location, Winter's classification, tooth morphology, number of teeth extracted, procedure type, and surgical experience (R2=0.58). No statistically significant differences were seen between the index sample and the validation sample (n=50, k=137) for any of the study variables. Compared with the index model, the β-coefficients of the validation model were similar in direction and magnitude for most variables. Compared with the observed extraction time for all teeth in the sample, the predicted extraction time was not significantly different (P=.16). CONCLUSIONS: Fair agreement was seen between the β-coefficients for our multiple models in the index and validation populations, with no significant difference in the predicted and observed operating times. CI - Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Susarla, Srinivas M AU - Susarla SM AD - Center for Applied Clinical Investigation, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA 02114, USA. SSUSARLA1@partners.org FAU - Dodson, Thomas B AU - Dodson TB LA - eng GR - K24-DE000448/DE/NIDCR NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20120923 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Cohort Studies MH - Female MH - Forecasting MH - Humans MH - Linear Models MH - Male MH - Mandible/surgery MH - Maxilla/surgery MH - Molar, Third/*surgery MH - *Operative Time MH - Prospective Studies MH - *Tooth Extraction EDAT- 2012/09/27 06:00 MHDA- 2013/02/12 06:00 CRDT- 2012/09/27 06:00 PHST- 2012/06/07 00:00 [received] PHST- 2012/08/07 00:00 [accepted] PHST- 2012/09/27 06:00 [entrez] PHST- 2012/09/27 06:00 [pubmed] PHST- 2013/02/12 06:00 [medline] AID - S0278-2391(12)01147-0 [pii] AID - 10.1016/j.joms.2012.08.004 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2013 Jan;71(1):5-13. doi: 10.1016/j.joms.2012.08.004. Epub 2012 Sep 23. PMID- 9541340 OWN - NLM STAT- MEDLINE DCOM- 19980414 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 56 IP - 4 DP - 1998 Apr TI - Evaluation of trismus, bite force, and pressure algometry after third molar surgery: a placebo-controlled study of ibuprofen. PG - 420-7; discussion 427-9 AB - PURPOSE: This study evaluated trismus, bite force, and pressure algometry as measures of analgesic efficacy after third molar removal. PATIENTS AND METHODS: Fifty-seven patients (36 females and 21 males) developed at least moderate pain after surgical removal of a mandibular third molar and were given either ibuprofen, 400 mg (n = 26), or placebo (n = 31) in a double-blind study. Pain intensity and pain relief were rated on a five-point verbal rating scale during the 4-hour study period. Recordings of trismus, bilateral pressure pain detection and tolerance thresholds, and bite force were performed before surgery, at medication, and hourly for 4 hours. Changes in the functional variables were calculated as percent change from baseline (before surgery). RESULTS: The pain intensity and pain relief ratings showed significant differences between the ibuprofen- and placebo-treated patients in the 4-hour study period. The changes in trismus, bite force, and pressure pain thresholds were in accordance with these pain ratings. Pressure pain detection threshold on the operated side was significantly lower in the placebo-treated patients compared with the ibuprofen-treated patients 2 and 3 hours after medication, whereas pressure tolerance threshold showed a significant difference after 2 hours. Bite force on the operated side was significantly less reduced 3 hours after treatment with ibuprofen when compared with placebo. CONCLUSIONS: The functional measures used support the results obtained by rating of pain intensity and pain relief, and could be of value as measures of the efficacy of an analgesic to reduce functional impairment caused by postoperative pain. FAU - Nørholt, S E AU - Nørholt SE AD - Department of Oral and Maxillofacial Surgery; Royal Dental College, Aarhus University and Aarhus University Hospital, Denmark. FAU - Aagaard, E AU - Aagaard E FAU - Svensson, P AU - Svensson P FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology MH - Bite Force MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/*pharmacology MH - Male MH - Mandible/physiopathology MH - Molar, Third/*surgery MH - Pain Measurement/methods MH - Pain, Postoperative/complications/*drug therapy/etiology MH - Range of Motion, Articular/drug effects MH - Sensory Thresholds/*drug effects MH - Tooth Extraction/adverse effects MH - Trismus/etiology/physiopathology EDAT- 1998/04/16 00:00 MHDA- 1998/04/16 00:01 CRDT- 1998/04/16 00:00 PHST- 1998/04/16 00:00 [pubmed] PHST- 1998/04/16 00:01 [medline] PHST- 1998/04/16 00:00 [entrez] AID - S0278-2391(98)90705-4 [pii] AID - 10.1016/s0278-2391(98)90705-4 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1998 Apr;56(4):420-7; discussion 427-9. doi: 10.1016/s0278-2391(98)90705-4. PMID- 18650733 OWN - NLM STAT- MEDLINE DCOM- 20081106 LR - 20131121 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 19 IP - 4 DP - 2008 Jul TI - The effects of systemic alendronate with or without intraalveolar collagen sponges on postextractive bone resorption: a single masked randomized clinical trial. PG - 1061-6 LID - 10.1097/SCS.0b013e3180a0331a [doi] AB - Alendronate is a bisphosphonate frequently used to reduce bone resorption. It has been used for osteoporosis, Paget's disease, and also as adjunctive therapy for periodontal disease. The aim of this study was to evaluate the effect of systemic alendronate with or without endoalveolar collagen sponge on vertical bone resorption after lower wisdom tooth extraction. Forty patients referred for wisdom tooth impaction were selected. Before surgery, patients were randomly assigned to receive one of the following pharmacologic treatments: no medication (group 1), postextractive endoalveolar collagen sponge (group 2), systemic alendronate for 4 months starting the day of surgery (group 3), and group 2 + group 3 (group 4). Standardized orthopantomographic evaluation was obtained during recruitment (T1), immediately after surgery (T2), and 4 months (T3) to evaluate crestal and alveolar socket changes. Results indicate that at T2, crest and socket level did not show significant differences between the four groups. At T3, test sites treated showed less bone resorption compared with controls. In particular, higher vertical bone height levels and a faster intraalveolar healing were achieved in groups 3 and 4. Systemically given alendronate may be used successfully to reduce vertical bone resorption after wisdom tooth extraction. FAU - Graziani, Filippo AU - Graziani F AD - Department of Surgery, Section of Oral Surgery, University of Pisa, Pisa, Italy. f.graziani@med.unipi.it FAU - Rosini, Stefano AU - Rosini S FAU - Cei, Silvia AU - Cei S FAU - La Ferla, Fabio AU - La Ferla F FAU - Gabriele, Mario AU - Gabriele M LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Biocompatible Materials) RN - 0 (Bone Density Conservation Agents) RN - 9007-34-5 (Collagen) RN - X1J18R4W8P (Alendronate) SB - D MH - Absorbable Implants MH - Adult MH - Alendronate/*therapeutic use MH - Alveolar Bone Loss/etiology/*prevention & control MH - Alveolar Process/drug effects/surgery MH - Biocompatible Materials/pharmacology MH - Bone Density Conservation Agents/*therapeutic use MH - Bone Regeneration/drug effects MH - Bone Resorption/*prevention & control MH - Collagen/pharmacology MH - Female MH - Guided Tissue Regeneration/methods MH - Humans MH - Male MH - Molar, Third/*surgery MH - Reference Values MH - Single-Blind Method MH - Surgical Sponges MH - Tooth Extraction/adverse effects MH - Tooth Socket/*drug effects MH - Treatment Outcome EDAT- 2008/07/25 09:00 MHDA- 2008/11/07 09:00 CRDT- 2008/07/25 09:00 PHST- 2008/07/25 09:00 [pubmed] PHST- 2008/11/07 09:00 [medline] PHST- 2008/07/25 09:00 [entrez] AID - 00001665-200807000-00034 [pii] AID - 10.1097/SCS.0b013e3180a0331a [doi] PST - ppublish SO - J Craniofac Surg. 2008 Jul;19(4):1061-6. doi: 10.1097/SCS.0b013e3180a0331a. PMID- 16902792 OWN - NLM STAT- MEDLINE DCOM- 20070220 LR - 20181113 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 62 IP - 9 DP - 2006 Sep TI - Efficacy of methylprednisolone in controlling complications after impacted lower third molar surgical extraction. PG - 693-8 AB - INTRODUCTION: Impacted third molar extraction causes considerable swelling in the days immediately following surgery. The aim of the present investigation was to evaluate the efficacy of methylprednisolone as a single 40-mg intramuscular dose in controlling the complications of impacted lower third molar surgical removal. MATERIALS AND METHODS: Thirty-five patients were evaluated within the framework of a consecutive sampling and double-blind study with intrasubject measurements. Extraction comprised ostectomy with tooth sectioning of both lower third molars under local anesthesia. The study group received 40 mg of methylprednisolone injected into the gluteal region, while the controls received no such medication. In each individual one molar was randomly assigned to the study group and the other to the control series - with extraction of the two teeth being spaced 1 month apart. Evaluations were made of postoperative pain, trismus and swelling, and measurements were obtained for oral aperture and various distances (tragus-lip commissure, gonion-lip commissure and gonion-external canthus of the eye) before surgery and 2-7 days after extraction. Statistical correlations were made based on the Student t-test for the comparison of means of related samples. RESULTS: A statistically and clinically significant association was observed 2 days after surgery between methylprednisolone administration and increased oral aperture and diminished facial swelling. Likewise, less pain was recorded in the study group 6 h after surgery. CONCLUSION: The results confirm the efficacy of methylprednisolone in providing a more comfortable postoperative course after surgical extraction of impacted lower third molars. FAU - Micó-Llorens, J M AU - Micó-Llorens JM AD - Master of Oral Surgery and Implantology, School of Dentistry of University of Barcelona, Barcelona, Spain. FAU - Satorres-Nieto, M AU - Satorres-Nieto M FAU - Gargallo-Albiol, J AU - Gargallo-Albiol J FAU - Arnabat-Domínguez, J AU - Arnabat-Domínguez J FAU - Berini-Aytés, L AU - Berini-Aytés L FAU - Gay-Escoda, C AU - Gay-Escoda C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20060811 PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - X4W7ZR7023 (Methylprednisolone) SB - IM MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Methylprednisolone/*therapeutic use MH - *Molar, Third MH - Postoperative Complications/*drug therapy MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 2006/08/12 09:00 MHDA- 2007/02/21 09:00 CRDT- 2006/08/12 09:00 PHST- 2005/03/17 00:00 [received] PHST- 2006/05/15 00:00 [accepted] PHST- 2006/08/12 09:00 [pubmed] PHST- 2007/02/21 09:00 [medline] PHST- 2006/08/12 09:00 [entrez] AID - 10.1007/s00228-006-0164-5 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 2006 Sep;62(9):693-8. doi: 10.1007/s00228-006-0164-5. Epub 2006 Aug 11. PMID- 15266731 OWN - NLM STAT- MEDLINE DCOM- 20040802 LR - 20151119 IS - 0019-6568 (Print) IS - 0019-6568 (Linking) VI - 83 IP - 1 DP - 2004 Spring TI - Handpiece speed and postoperative outcomes in third molar surgery. PG - 4-6 AB - OBJECTIVE: This study was performed to assess surgical outcomes when externally irrigated slow-speed surgical handpieces (30,000 rpm) were compared to externally irrigated high-speed handpieces (90,000 rpm) in the removal of impacted lower third molar teeth. STUDY DESIGN: One hundred patients with bilater ally impacted third molar s were enrolled in the study; 53 remained to completion. Each patient served as his/her own control. The experimental side was treated using a 30,000 rpm electric rotary drill incorporating irrigation, while the control side was treated using the same drill system, but with a 90,000 rpm handpiece. Drill speeds used were alternated between the right and left sides of patients to avoid bias introduced by the dominant hand of the surgeon. Patients were blinded to drill speed, and were asked to complete a standardized pain/swelling questionnaire for seven days immediately following surgery. Data was analyzed to determine differences in pain, swelling, and complications in relation to the drill type used. RESULTS: No statistically significant differences were found in degree of pain, swelling, or complications when the slower drill was compared to the high-speed instrument. CONCLUSIONS: The study suggests that there is no difference in postoperative outcome when impacted third molar teeth are removed with either slow- or high-speed instrumentation, and that the choice of the drill type should be determined solely by the preference of the operator. FAU - Campbell, John H AU - Campbell JH AD - Indiana University School of Dentistry, Department of Oral Surgery and Hospital Dentistry, USA. FAU - Murray, R Anthony AU - Murray RA LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Indiana Dent Assoc JT - Journal (Indiana Dental Association) JID - 8502537 SB - D MH - Analysis of Variance MH - Chi-Square Distribution MH - *Dental High-Speed Equipment MH - Dental High-Speed Technique MH - Humans MH - Molar, Third/surgery MH - Odds Ratio MH - Single-Blind Method MH - Surveys and Questionnaires MH - Tooth Extraction/*instrumentation MH - Tooth, Impacted/surgery EDAT- 2004/07/23 05:00 MHDA- 2004/08/03 05:00 CRDT- 2004/07/23 05:00 PHST- 2004/07/23 05:00 [pubmed] PHST- 2004/08/03 05:00 [medline] PHST- 2004/07/23 05:00 [entrez] PST - ppublish SO - J Indiana Dent Assoc. 2004 Spring;83(1):4-6. PMID- 17636762 OWN - NLM STAT- MEDLINE DCOM- 20071018 LR - 20200814 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 2007 IP - 3 DP - 2007 Jul 18 TI - Paracetamol for pain relief after surgical removal of lower wisdom teeth. PG - CD004487 LID - CD004487 AB - BACKGROUND: Paracetamol has been commonly used for the relief of postoperative pain following oral surgery. In this review we investigated the optimal dose of paracetamol and the optimal time for drug administration to provide pain relief, taking into account the side effects of different doses of the drug. This will inform dentists and their patients of the best strategy for pain relief after the surgical removal of wisdom teeth. OBJECTIVES: To assess the beneficial and harmful effects of paracetamol for pain relief after surgical removal of lower wisdom teeth, compared to placebo, at different doses and administered postoperatively. SEARCH STRATEGY: We searched the Cochrane Oral Health Group's Trials Register; the Cochrane Pain, Palliative and Supportive Care Group's Trials Register; CENTRAL; MEDLINE; EMBASE and the Current Controlled Trials Register. Handsearching included several dental journals. We checked the bibliographies of relevant clinical trials and review articles for studies outside the handsearched journals. We wrote to authors of the identified randomised controlled trials (RCTs), to manufacturers of analgesic pharmaceuticals, we searched personal references in an attempt to identify unpublished or ongoing RCTs. No language restriction was applied. The last electronic search was conducted on 24th August 2006. SELECTION CRITERIA: Randomised, parallel group, placebo controlled, double blind clinical trials of paracetamol for acute pain, following third molar surgery. DATA COLLECTION AND ANALYSIS: All trials identified were scanned independently and in duplicate by two review authors, any disagreements were resolved by discussion, or if necessary a third review author was consulted. The proportion of patients with at least 50% pain relief was calculated for both paracetamol and placebo. The number of patients experiencing adverse events, and/or the total number of adverse events reported were analysed. MAIN RESULTS: Twenty-one trials met the inclusion criteria. A total of 2048 patients were initially enrolled in the trials (1148 received paracetamol, and 892 the placebo) and of these 1968 (96%) were included in the meta-analysis (1133 received paracetamol, and 835 the placebo). Paracetamol provided a statistically significant benefit when compared with placebo for pain relief and pain intensity at both 4 and 6 hours. Most studies were found to have moderate risk of bias, with poorly reported allocation concealment being the main problem. Risk ratio values for pain relief at 4 hours 2.85 (95% confidence interval (CI) 1.89 to 4.29), and at 6 hours 3.32 (95% CI 1.88 to 5.87). A statistically significant benefit was also found between up to 1000 mg and 1000 mg doses, the higher the dose giving greater benefit for each measure at both time points. There was no statistically significant difference between the number of patients who reported adverse events, overall this being 19% in the paracetamol group and 16% in the placebo group. AUTHORS' CONCLUSIONS: Paracetamol is a safe, effective drug for the treatment of postoperative pain following the surgical removal of lower wisdom teeth. FAU - Weil, K AU - Weil K AD - School of Dentistry, University of Manchester, Oral and Maxillofacial Surgery, Higher Cambridge Street, Manchester, UK, M15 6FH. kiaran_weil@hotmail.com FAU - Hooper, L AU - Hooper L FAU - Afzal, Z AU - Afzal Z FAU - Esposito, M AU - Esposito M FAU - Worthington, H V AU - Worthington HV FAU - van Wijk, A J AU - van Wijk AJ FAU - Coulthard, P AU - Coulthard P LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20070718 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) SB - IM CIN - Evid Based Dent. 2007;8(3):79-80. PMID: 17891124 CIN - J Evid Based Dent Pract. 2009 Dec;9(4):211-2. PMID: 19913736 MH - Acetaminophen/adverse effects/*therapeutic use MH - Analgesics, Non-Narcotic/adverse effects/*therapeutic use MH - Humans MH - Molar, Third/*surgery MH - Outcome Assessment, Health Care MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*adverse effects PMC - PMC7388061 COIS- None known. EDAT- 2007/07/20 09:00 MHDA- 2007/10/19 09:00 CRDT- 2007/07/20 09:00 PHST- 2007/07/20 09:00 [pubmed] PHST- 2007/10/19 09:00 [medline] PHST- 2007/07/20 09:00 [entrez] AID - CD004487.pub2 [pii] AID - 10.1002/14651858.CD004487.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD004487. doi: 10.1002/14651858.CD004487.pub2. PMID- 23649080 OWN - NLM STAT- MEDLINE DCOM- 20140424 LR - 20130507 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 23 IP - 6 DP - 2012 Nov-Dec TI - Sublingual piroxicam in the management of postoperative pain after surgical removal of impacted mandibular third molar. PG - 839-40 LID - 10.4103/0970-9290.111282 [doi] AB - INTRODUCTION: Surgical removal of impacted mandibular third molar is one of the most commonly performed procedures in oral and maxillofacial surgical practice. The role of preoperative and postoperative medications for management of postoperative complications has been extensively evaluated. AIM: To assess the therapeutic effect of a single dose of 40 mg sublingual piroxicam (study group) vs 150 mg oral diclofenac (50 mg thrice a day) (control group) in patients undergoing surgical removal of impacted mandibular third molar. MATERIALS AND METHODS: A total of 100 patients with asymptomatic impacted mandibular third molars were randomized into two groups. One group received two 20-mg tablets of piroxicam once daily on the first and second postoperative days, followed by one 20-mg tablet on the third post-operative day. The other group received one tablet of diclofenac 50 mg orally thrice daily on the first, second, and third post-operative days. Repeated extraoral examinations were done for continuous assessment of swelling, trismus, and reduction in pain. Overall impression of the treating physician and the patient regarding efficacy of study drugs were recorded at the end of the study. RESULTS: In the piroxicam group there was >50% reduction in pain on all three days postoperatively. The incidence of swelling and trismus was found to be higher in the control group as compared to the study group. Adverse events, such as gastrointestinal (GI) disturbances, were significantly higher in the diclofenac group (11%) as compared to the piroxicam group (0%). CONCLUSION: Two sublingual piroxicam 20 mg tablets once daily has better efficacy and tolerability profile than diclofenac 50 mg one tablet thrice daily in the management of pain after surgical removal of impacted mandibular third molar. FAU - Mohammad, Shadab AU - Mohammad S AD - Department of Oral and Maxillofacial Surgery, King George University of Dental Sciences, Lucknow, UP, India. FAU - Singh, Vibha AU - Singh V FAU - Wadhwani, Puneet AU - Wadhwani P FAU - Tayade, Himanshu P AU - Tayade HP FAU - Rathod, Onkar K AU - Rathod OK LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Tablets) RN - 13T4O6VMAM (Piroxicam) RN - 144O8QL0L1 (Diclofenac) SB - D MH - Administration, Oral MH - Administration, Sublingual MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Diclofenac/administration & dosage/adverse effects MH - Edema/etiology MH - Female MH - Follow-Up Studies MH - Gastrointestinal Diseases/chemically induced MH - Humans MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Patient Satisfaction MH - Piroxicam/*administration & dosage MH - Postoperative Complications MH - Tablets MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/etiology MH - Young Adult EDAT- 2013/05/08 06:00 MHDA- 2014/04/25 06:00 CRDT- 2013/05/08 06:00 PHST- 2013/05/08 06:00 [entrez] PHST- 2013/05/08 06:00 [pubmed] PHST- 2014/04/25 06:00 [medline] AID - IndianJDentRes_2012_23_6_839_111282 [pii] AID - 10.4103/0970-9290.111282 [doi] PST - ppublish SO - Indian J Dent Res. 2012 Nov-Dec;23(6):839-40. doi: 10.4103/0970-9290.111282. PMID- 21519580 OWN - NLM STAT- MEDLINE DCOM- 20110923 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 42 IP - 6 DP - 2011 Jun TI - Complications in surgical removal of impacted mandibular third molars in relation to flap design: clinical and statistical evaluations. PG - 445-53 AB - OBJECTIVE: The extraction of an impacted mandibular third molar may result in periodontal complications on the distal surface of the adjacent second molar. The purpose of this study was to compare the influence of three full-thickness flaps on the periodontal healing of the adjacent second molar after extraction of impacted mandibular third molars. METHOD AND MATERIALS: Forty-five volunteers with bilateral impaction of the mandibular third molars were selected. Each patient was randomly assigned to one of three groups: group A (envelope flap modified by Thibauld and Parant), group B (Laskin triangular flap), and group C (envelope flap modified by Laskin). The periodontal health of the second molars was evaluated at 3, 6, 12, and 24 months after surgery via clinical measurements. RESULTS: After 21 days, there was no correlation between postoperative complications (such as edema and alveolitis) and flap design. However, there was a statistically significant reduction of pocket probing depth (PPD) and increase of clinical attachment level (CAL) in group B compared to the other groups (P<.05) 24 months after surgery. CONCLUSION: The effect of the type of flap used for mandibular third molar surgery on the periodontal status of the second molars as well as the factors that influence this outcome remains uncertain. Regardless of the flap design, the periodontal conditions of the adjacent second molar deteriorated after 12 and 24 months. The decision to use a certain type of flap should be based on the surgeon's preference. CI - © 2011 By Quintessence Publishing Co, Inc. FAU - Briguglio, Francesco AU - Briguglio F AD - Department of Odontostomatology, University of Messina, Messina, Italy. FAU - Zenobio, Elton G AU - Zenobio EG FAU - Isola, Gaetano AU - Isola G FAU - Briguglio, Roberto AU - Briguglio R FAU - Briguglio, Enrico AU - Briguglio E FAU - Farronato, Davide AU - Farronato D FAU - Shibli, Jamil Awad AU - Shibli JA LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Adolescent MH - Adult MH - Dental Plaque Index MH - Double-Blind Method MH - Follow-Up Studies MH - Gingival Hemorrhage/classification MH - Humans MH - Mandible/*surgery MH - Middle Aged MH - Molar/pathology MH - Molar, Third/*surgery MH - Osteotomy/methods MH - Pain, Postoperative/etiology MH - Periodontal Attachment Loss/classification MH - Periodontal Index MH - Periodontal Pocket/classification MH - Periodontium/surgery MH - *Postoperative Complications MH - Surgical Flaps/*classification/statistics & numerical data MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Wound Healing/physiology MH - Young Adult EDAT- 2011/04/27 06:00 MHDA- 2011/09/29 06:00 CRDT- 2011/04/27 06:00 PHST- 2011/04/27 06:00 [entrez] PHST- 2011/04/27 06:00 [pubmed] PHST- 2011/09/29 06:00 [medline] AID - 840404 [pii] PST - ppublish SO - Quintessence Int. 2011 Jun;42(6):445-53. PMID- 18022467 OWN - NLM STAT- MEDLINE DCOM- 20071221 LR - 20161124 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 65 IP - 12 DP - 2007 Dec TI - Epinephrine concentration (1:100,000 or 1:200,000) does not affect the clinical efficacy of 4% articaine for lower third molar removal: a double-blind, randomized, crossover study. PG - 2445-52 AB - PURPOSE: This study compared the use of 4% articaine in association with 1:100,000 (10 mug/mL; A100) or 1:200,000 (5 mug/mL; A200) epinephrine in lower third molar removal. PATIENTS AND METHODS: Fifty healthy volunteers underwent removal of symmetrically positioned lower third molars, in 2 separate appointments, under local anesthesia with either A100 or A200, in a double-blind, randomized, and crossed manner. Latency, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, and hemodynamic parameters were evaluated. RESULTS: A100 and A200 presented very similar latency (1.64 +/- 0.08 and 1.58 +/- 0.08 minutes, respectively; P > .05). Identical volumes of both anesthetic solutions were used: 2.7 mL = 108 mg of articaine plus 27 mug (A100) or 13.5 mug (A200) of epinephrine. The 2 solutions provided similar duration of postoperative analgesia regardless of bone removal (around 200 minutes; P > .05). The 2 solutions also had a similar duration of anesthetic action on soft tissues (around 250 minutes; P > .05). The surgeon's rating of intraoperative bleeding was considered very close to minimal. Transient changes in hemodynamic parameters were observed, but these were neither clinically significant nor attributable to the type of anesthetic used (P > .05). CONCLUSIONS: An epinephrine concentration of 1:100,000 or 1:200,000 in 4% articaine solution does not affect the clinical efficacy of this local anesthetic. It is possible to successfully use the 4% articaine formulation with a lower concentration of epinephrine (1:200,000 or 5 mug/mL) for lower third molar extraction with or without bone removal. FAU - Santos, Carlos F AU - Santos CF AD - Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil. FAU - Modena, Karin C S AU - Modena KC FAU - Giglio, Fernando P M AU - Giglio FP FAU - Sakai, Vivien T AU - Sakai VT FAU - Calvo, Adriana M AU - Calvo AM FAU - Colombini, Bella L AU - Colombini BL FAU - Sipert, Carla R AU - Sipert CR FAU - Dionísio, Thiago J AU - Dionísio TJ FAU - Faria, Flávio A C AU - Faria FA FAU - Trindade, Alceu S Jr AU - Trindade AS Jr FAU - Lauris, José R P AU - Lauris JR LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Combined) RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - D3SQ406G9X (Carticaine) RN - YKH834O4BH (Epinephrine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesia/methods MH - Anesthesia, Dental/methods MH - Anesthetics, Combined/*administration & dosage MH - Anesthetics, Local/*administration & dosage MH - Blood Pressure/drug effects MH - Carticaine/*administration & dosage MH - Cross-Over Studies MH - Double-Blind Method MH - Drug Interactions MH - Epinephrine/*administration & dosage MH - Female MH - Heart Rate/drug effects MH - Humans MH - Male MH - Mandible/diagnostic imaging/surgery MH - Molar, Third/diagnostic imaging/*surgery MH - Radiography MH - Statistics, Nonparametric MH - Time Factors MH - Tooth Extraction/adverse effects MH - Vasoconstrictor Agents/*administration & dosage EDAT- 2007/11/21 09:00 MHDA- 2007/12/22 09:00 CRDT- 2007/11/21 09:00 PHST- 2006/07/27 00:00 [received] PHST- 2006/11/23 00:00 [revised] PHST- 2007/04/09 00:00 [accepted] PHST- 2007/11/21 09:00 [pubmed] PHST- 2007/12/22 09:00 [medline] PHST- 2007/11/21 09:00 [entrez] AID - S0278-2391(07)00521-6 [pii] AID - 10.1016/j.joms.2007.04.020 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2007 Dec;65(12):2445-52. doi: 10.1016/j.joms.2007.04.020. PMID- 25847016 OWN - NLM STAT- MEDLINE DCOM- 20160311 LR - 20150608 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 44 IP - 7 DP - 2015 Jul TI - Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study. PG - 876-84 LID - S0901-5027(15)00107-1 [pii] LID - 10.1016/j.ijom.2014.10.026 [doi] AB - This study aimed to compare the effect of nimesulide and ketoprofen on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in patients undergoing removal of four third molars. Eighteen eligible patients were allocated to one of two groups to receive treatment two times a day with either ketoprofen 100 mg or nimesulide 100 mg for a period of 3 days. The rescue medication intake (number) and pain intensity were evaluated at 6, 12, 24, and 48 h, and at 7 days postoperatively. Swelling and maximum mouth opening were evaluated at 24 h, 72 h, and 7 days postoperatively. The peak pain score occurred at 6h after surgery in the nimesulide group and at 12h in the ketoprofen group. There was no statistically significant difference between the groups, although pain relief was observed after 48 h in the nimesulide group and after 7 days in the ketoprofen group. For each group, there was a statically significant difference in pain scores among the studied periods (P<0.0001). None of the patients required rescue medication. There was a statistically significant difference in maximum mouth opening between the preoperative and postoperative periods (P<0.0001). Ketoprofen and nimesulide were effective at controlling pain, swelling, and trismus after the surgical removal of third molars. CI - Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Pouchain, E C AU - Pouchain EC AD - Postgraduate Residency Program in Oral and Maxillofacial Surgery, Walter Cantídio University Hospital, Fortaleza, Ceará, Brazil. FAU - Costa, F W G AU - Costa FW AD - Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: fwildson@yahoo.com.br. FAU - Bezerra, T P AU - Bezerra TP AD - Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. FAU - Soares, E C S AU - Soares EC AD - Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150403 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Calcium Channel Blockers) RN - 0 (Sulfonamides) RN - 90Y4QC304K (Ketoprofen) RN - V4TKW1454M (nimesulide) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Calcium Channel Blockers/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Ketoprofen/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - *Pain Management MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Pilot Projects MH - Prospective Studies MH - Sulfonamides/*therapeutic use MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome OTO - NOTNLM OT - analgesia OT - ketoprofen OT - nimesulide OT - split-mouth OT - third molar EDAT- 2015/04/08 06:00 MHDA- 2016/03/12 06:00 CRDT- 2015/04/08 06:00 PHST- 2014/01/08 00:00 [received] PHST- 2014/09/30 00:00 [revised] PHST- 2014/10/22 00:00 [accepted] PHST- 2015/04/08 06:00 [entrez] PHST- 2015/04/08 06:00 [pubmed] PHST- 2016/03/12 06:00 [medline] AID - S0901-5027(15)00107-1 [pii] AID - 10.1016/j.ijom.2014.10.026 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2015 Jul;44(7):876-84. doi: 10.1016/j.ijom.2014.10.026. Epub 2015 Apr 3. PMID- 21617973 OWN - NLM STAT- MEDLINE DCOM- 20120809 LR - 20181113 IS - 1435-604X (Electronic) IS - 0268-8921 (Linking) VI - 27 IP - 3 DP - 2012 May TI - Efficacy of low-level laser therapy in the management of pain, facial swelling, and postoperative trismus after a lower third molar extraction. A preliminary study. PG - 559-66 LID - 10.1007/s10103-011-0936-8 [doi] AB - Pain, swelling, and trismus are the most common complications after surgical removal of impacted lower third molars. The aim of this study was to evaluate the analgesic and anti-inflammatory effects of a low-level laser therapy (Laser Smile™, Biolase®, San Clemente, USA) applied to the wound appeared after the surgical removal of impacted lower third molars. A prospective, randomized, and double-blind study was undertaken in 20 healthy patients with two symmetrically impacted lower third molars. The application of a low-level laser was made randomly on one of the two sides after surgery. The experimental side received 5 J/cm(2) of energy density, a wavelength of 810 nm, and an output power of 0.5 W. On the control side, a handpiece was applied intraorally, but the laser was not activated. Evaluations of postoperative pain, trismus, and swelling were made. The sample consisted of 11 women and nine men, and mean age was 23.35 years (18-37). The pain level in the first hours after surgery was lower in the experimental side than in the placebo side, although without statistically significant differences (p = 0.258). Swelling and trismus at the 2nd and 7th postoperative days were slightly higher in the control side, although not statistically significant differences were detected (p > 0.05). The application of a low-level laser with the parameters used in this study did not show beneficial affects in reducing pain, swelling, and trismus after removal of impacted lower third molars. FAU - López-Ramírez, Marta AU - López-Ramírez M AD - Barcelona University Dental School, Barcelona, Spain. FAU - Vílchez-Pérez, Miguel Angel AU - Vílchez-Pérez MA FAU - Gargallo-Albiol, Jordi AU - Gargallo-Albiol J FAU - Arnabat-Domínguez, Josep AU - Arnabat-Domínguez J FAU - Gay-Escoda, Cosme AU - Gay-Escoda C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20110527 PL - England TA - Lasers Med Sci JT - Lasers in medical science JID - 8611515 SB - IM MH - Adolescent MH - Adult MH - Double-Blind Method MH - Edema/etiology/*radiotherapy MH - Face MH - Female MH - Humans MH - Lasers, Semiconductor/*therapeutic use MH - *Low-Level Light Therapy MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/etiology/*radiotherapy MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Trismus/etiology/*radiotherapy MH - Young Adult EDAT- 2011/05/28 06:00 MHDA- 2012/08/10 06:00 CRDT- 2011/05/28 06:00 PHST- 2011/01/31 00:00 [received] PHST- 2011/05/09 00:00 [accepted] PHST- 2011/05/28 06:00 [entrez] PHST- 2011/05/28 06:00 [pubmed] PHST- 2012/08/10 06:00 [medline] AID - 10.1007/s10103-011-0936-8 [doi] PST - ppublish SO - Lasers Med Sci. 2012 May;27(3):559-66. doi: 10.1007/s10103-011-0936-8. Epub 2011 May 27. PMID- 18603410 OWN - NLM STAT- MEDLINE DCOM- 20081218 LR - 20111117 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 37 IP - 9 DP - 2008 Sep TI - Effect of ice compression on pain after mandibular third molar surgery: a single-blind, randomized controlled trial. PG - 824-30 LID - 10.1016/j.ijom.2008.05.011 [doi] AB - This study was designed to investigate the effect of compression with ice and compression alone on pain and quality of life after surgical removal of mandibular third molars. A prospective, single-blind, randomized controlled study design was chosen. Participants in group A applied 45 min of repeated compression with ice; those in group B applied 45 min of repeated compression without ice (control); and those in group C did not apply any compression. Pain intensity was measured on a visual analogue scale (VAS) three times a day for seven days. At day seven, overall pain reduction was scored on a global perceived effect (GPE) scale and a quality-of-life questionnaire was completed. Ninety-five patients completed the trial. The VAS scores demonstrated a significant pain decrease in groups A and B three days postoperatively. No significant differences were observed between groups A and B. Based on the GPE ratings, in groups A and B more patients indicated that pain was reduced successfully, but this was not statistically significant. Quality of life was significantly better for patients in groups A and B. These results demonstrate that compression after surgical removal of mandibular third molars is a valuable method for preventing pain. FAU - Forouzanfar, T AU - Forouzanfar T AD - Department of Oral and Maxillofacial Surgery, VU University Medical Center/Academic Centre for Dentistry Amsterdam, The Netherlands. t.forouzanfar@vumc.nl FAU - Sabelis, A AU - Sabelis A FAU - Ausems, S AU - Ausems S FAU - Baart, J A AU - Baart JA FAU - van der Waal, I AU - van der Waal I LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20080707 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Ice) SB - D SB - IM CIN - Int J Oral Maxillofac Surg. 2009 Apr;38(4):395; author reply 395-6. PMID: 19185464 MH - Adolescent MH - Adult MH - Cryotherapy/*methods MH - Female MH - Humans MH - Ice MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/surgery MH - Pain/etiology MH - *Pain Management MH - Pain Measurement/methods MH - Postoperative Complications/*therapy MH - *Pressure MH - Prospective Studies MH - Quality of Life MH - Single-Blind Method MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Young Adult EDAT- 2008/07/08 09:00 MHDA- 2008/12/19 09:00 CRDT- 2008/07/08 09:00 PHST- 2007/06/19 00:00 [received] PHST- 2008/02/25 00:00 [revised] PHST- 2008/05/16 00:00 [accepted] PHST- 2008/07/08 09:00 [pubmed] PHST- 2008/12/19 09:00 [medline] PHST- 2008/07/08 09:00 [entrez] AID - S0901-5027(08)00201-4 [pii] AID - 10.1016/j.ijom.2008.05.011 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2008 Sep;37(9):824-30. doi: 10.1016/j.ijom.2008.05.011. Epub 2008 Jul 7. PMID- 29773239 OWN - NLM STAT- MEDLINE DCOM- 20181227 LR - 20181227 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 56 IP - 6 DP - 2018 Jul TI - Re: Effectiveness of irrigation with chlorhexidine after removal of mandibular third molars: a randomised controlled trial. PG - 563 LID - S0266-4356(18)30136-0 [pii] LID - 10.1016/j.bjoms.2018.04.012 [doi] FAU - Pellatt, A AU - Pellatt A AD - Oral and Maxillofacial Surgery Department, University Hospital Bristol NHS Trust. Electronic address: annie.pellatt@uhbristol.nhs.uk. FAU - Collin, J AU - Collin J AD - Oral and Maxillofacial Surgery Department, University Hospital Bristol NHS Trust. FAU - Hughes, C W AU - Hughes CW AD - Oral and Maxillofacial Surgery Department, University Hospital Bristol NHS Trust. LA - eng PT - Comment PT - Letter PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM CON - Br J Oral Maxillofac Surg. 2018 Jan;56(1):54-59. PMID: 29223633 MH - *Chlorhexidine MH - Dry Socket MH - Humans MH - Molar MH - *Molar, Third MH - Tooth, Impacted EDAT- 2018/05/19 06:00 MHDA- 2018/12/28 06:00 CRDT- 2018/05/19 06:00 PHST- 2018/03/16 00:00 [received] PHST- 2018/04/25 00:00 [accepted] PHST- 2018/05/19 06:00 [pubmed] PHST- 2018/12/28 06:00 [medline] PHST- 2018/05/19 06:00 [entrez] AID - S0266-4356(18)30136-0 [pii] AID - 10.1016/j.bjoms.2018.04.012 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2018 Jul;56(6):563. doi: 10.1016/j.bjoms.2018.04.012. PMID- 21764203 OWN - NLM STAT- MEDLINE DCOM- 20111108 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 10 DP - 2011 Oct TI - Comparison of the effects of warfarin and heparin on bleeding caused by dental extraction: a clinical study. PG - 2500-7 LID - 10.1016/j.joms.2011.02.134 [doi] AB - PURPOSE: Replacement of warfarin with heparin for dental extractions in patients on long-term warfarin therapy is associated with wasted time, consumed labor, and increased treatment expenses. The aim of this study was to evaluate the safety of dental extraction without altering the warfarin regimen in patients with an international normalized ratio from 1 to 4. PATIENTS AND METHODS: Forty patients who underwent tooth extraction were divided into 4 groups: continuation of warfarin without interruption (group 1), warfarin bridged with low-molecular-weight heparin (group 2), warfarin bridged with unfractionated heparin (group 3), and a control group of healthy individuals (group 4). Total amount of bleeding (milligrams) was measured for 20 minutes after tooth extraction. International normalized ratio values on the operative day and number of extra gauze swabs used for bleeding control in the first 48 hours were recorded for each patient. Results were statistically analyzed by analysis of variance, Fisher least-significant difference post hoc test, Pearson correlation, χ(2) test, and Student t test. RESULTS: Mean amounts of bleeding were 2,486 ± 1,408; 999 ± 425; 1,288 ± 982; and 1,736 ± 876 mg for groups 1, 2, 3, and 4, respectively. There was no severe postoperative bleeding in any patient and the number of used extra gauze swabs did not differ significantly among groups. CONCLUSION: With the aid of local hemostatic agents, dental extraction in patients receiving warfarin who have an international normalized ratio from 1 to 4 could be carried out without a significant risk of bleeding and without altering the anticoagulant regimen. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Karslı, Ebru Deniz AU - Karslı ED AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Çukurova University, Adana, Turkey. FAU - Erdogan, Özgür AU - Erdogan Ö FAU - Esen, Emin AU - Esen E FAU - Acartürk, Esmeray AU - Acartürk E LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110720 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anticoagulants) RN - 0 (Heparin, Low-Molecular-Weight) RN - 5Q7ZVV76EI (Warfarin) RN - 9005-49-6 (Heparin) SB - AIM SB - D SB - IM MH - Adult MH - Aged MH - Analysis of Variance MH - Anticoagulants/*administration & dosage MH - Blood Loss, Surgical/*prevention & control MH - Chi-Square Distribution MH - *Dental Care for Chronically Ill MH - Endpoint Determination MH - Female MH - *Heart Valve Prosthesis MH - Hemostatic Techniques MH - Heparin/*administration & dosage MH - Heparin, Low-Molecular-Weight/*administration & dosage MH - Humans MH - International Normalized Ratio MH - Male MH - Middle Aged MH - Statistics, Nonparametric MH - *Tooth Extraction MH - Warfarin/*administration & dosage EDAT- 2011/07/19 06:00 MHDA- 2011/11/09 06:00 CRDT- 2011/07/19 06:00 PHST- 2010/10/29 00:00 [received] PHST- 2011/02/18 00:00 [revised] PHST- 2011/02/23 00:00 [accepted] PHST- 2011/07/19 06:00 [entrez] PHST- 2011/07/19 06:00 [pubmed] PHST- 2011/11/09 06:00 [medline] AID - S0278-2391(11)00408-3 [pii] AID - 10.1016/j.joms.2011.02.134 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Oct;69(10):2500-7. doi: 10.1016/j.joms.2011.02.134. Epub 2011 Jul 20. PMID- 24922557 OWN - NLM STAT- MEDLINE DCOM- 20141023 LR - 20181113 IS - 0250-832X (Print) IS - 1476-542X (Electronic) IS - 0250-832X (Linking) VI - 43 IP - 6 DP - 2014 TI - Image and surgery-related costs comparing cone beam CT and panoramic imaging before removal of impacted mandibular third molars. PG - 20140001 LID - 10.1259/dmfr.20140001 [doi] LID - 20140001 AB - OBJECTIVES: The aim of this prospective clinical study was to derive the absolute and relative costs of cone beam CT (CBCT) and panoramic imaging before removal of an impacted mandibular third molar. Furthermore, the study aimed to analyse the influence of different cost-setting scenarios on the outcome of the absolute and relative costs and the incremental costs related to surgery. METHODS: A randomized clinical trial compared complications following surgical removal of a mandibular third molar, where the pre-operative diagnostic method had been panoramic imaging or CBCT. The resources implied in the two methods were measured with health economic tools. The primary outcome was total costs defined as the sum of absolute imaging costs and incremental surgery-related costs. The basic variables were capital costs, operational costs, radiological costs, radiographic costs, overheads and patient resource utilization. Differences in resources used for surgical and post-surgical management were calculated for each patient. RESULTS: Converted to monetary units, the total costs for panoramic imaging equalized €49.29 and for CBCT examination €184.44. Modifying effects on this outcome such as differences in surgery time, treatment time for complications, pre- and post-surgical medication, sickness absence, specialist treatment and hospitalization were not statistically significant between the two diagnostic method groups. CONCLUSIONS: Costs for a CBCT examination were approximately four times the costs for panoramic imaging when used prior to removal of a mandibular third molar. The use of CBCT did not change the resources used for surgery, post-surgical treatment and patient complication management. FAU - Petersen, L B AU - Petersen LB AD - Section for Oral Radiology, Department of Dentistry, Aarhus University, Aarhus, Denmark. FAU - Olsen, K R AU - Olsen KR FAU - Christensen, J AU - Christensen J FAU - Wenzel, A AU - Wenzel A LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20140612 TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - D MH - Absenteeism MH - Adolescent MH - Adult MH - Aged MH - Capital Expenditures MH - Cone-Beam Computed Tomography/*economics MH - Cost of Illness MH - Drug Costs MH - Female MH - Health Care Costs MH - Hospitalization/economics MH - Humans MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Operative Time MH - Postoperative Complications/economics MH - Prospective Studies MH - Radiography, Panoramic/*economics MH - Specialties, Dental/economics MH - Tooth Extraction/*economics MH - Tooth, Impacted/economics/*surgery MH - Young Adult PMC - PMC4141671 OTO - NOTNLM OT - CBCT scanning OT - cost analysis OT - panoramic imaging OT - third molar surgery EDAT- 2014/06/13 06:00 MHDA- 2014/10/24 06:00 CRDT- 2014/06/13 06:00 PHST- 2014/06/13 06:00 [entrez] PHST- 2014/06/13 06:00 [pubmed] PHST- 2014/10/24 06:00 [medline] AID - 10.1259/dmfr.20140001 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 2014;43(6):20140001. doi: 10.1259/dmfr.20140001. Epub 2014 Jun 12. PMID- 19196113 OWN - NLM STAT- MEDLINE DCOM- 20100909 LR - 20151119 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 27 IP - 1 DP - 2009 Feb TI - The effect of low-level laser therapy on trismus and facial swelling following surgical extraction of a lower third molar. PG - 21-4 LID - 10.1089/pho.2008.2258 [doi] AB - OBJECTIVE: The purpose of this study was to evaluate the effect of low-level laser therapy (LLLT) on postoperative trismus and edema after the removal of mandibular third molars. MATERIALS AND METHODS: Thirty-two patients who were to undergo surgical removal of lower third molars were studied. Patients were randomly allocated to two groups, LLLT and placebo. Patients in the LLLT group received 12 J (4 J/cm(2)) low-level laser irradiation to the operative side intraorally 1 cm from the target tissue, and to the masseter muscle extraorally immediately after surgery. In the placebo group the handpiece was inserted into the operative side intraorally and was applied to the masseter muscle extraorally each for 1 min, but laser power was not activated. Inter-incisal opening and facial swelling were evaluated on postoperative days 2 and 7. Student's t-test used to analyze the data. RESULTS: It was determined that the trismus and the swelling in LLLT group were significantly less than in the placebo group on postoperative days 2 and 7. CONCLUSION: Within the limitations of this study it can be concluded that LLLT can be beneficial for the reduction of postoperative trismus and swelling after third molar surgery. FAU - Aras, Mutan Hamdi AU - Aras MH AD - Ataturk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Erzurum, Turkey. mutanhamdi@hotmail.com FAU - Güngörmüş, Metin AU - Güngörmüş M LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 SB - IM MH - Adult MH - Edema/etiology/*prevention & control MH - Female MH - Humans MH - *Low-Level Light Therapy MH - Male MH - Molar, Third/*surgery MH - Postoperative Hemorrhage MH - Tooth Extraction/*adverse effects MH - Trismus/etiology/*prevention & control MH - Young Adult EDAT- 2009/02/07 09:00 MHDA- 2010/09/10 06:00 CRDT- 2009/02/07 09:00 PHST- 2009/02/07 09:00 [entrez] PHST- 2009/02/07 09:00 [pubmed] PHST- 2010/09/10 06:00 [medline] AID - 10.1089/pho.2008.2258 [pii] AID - 10.1089/pho.2008.2258 [doi] PST - ppublish SO - Photomed Laser Surg. 2009 Feb;27(1):21-4. doi: 10.1089/pho.2008.2258. PMID- 18412725 OWN - NLM STAT- MEDLINE DCOM- 20080519 LR - 20100429 IS - 1601-5037 (Electronic) IS - 1601-5029 (Linking) VI - 6 IP - 2 DP - 2008 May TI - Effects of surgical removal of mandibular third molar on the periodontium of the second molar. PG - 123-8 LID - 10.1111/j.1601-5037.2008.00297.x [doi] AB - OBJECTIVE: The effects on periodontal tissues of adjacent second molars after semi-impacted mandibular third molar surgery were evaluated. The influence of flap design was studied. METHODS: Twenty volunteers randomly underwent the three-cornered flap technique (group A) or the distal wedge flap technique (group B). The periodontal probing depth was measured by using a 'Williams'-type probe just prior to surgery and three months post-operatively. Six sites, mesio-buccal, buccal, disto-buccal, disto-lingual, lingual and mesio-lingual, around the second molar were selected for measurement. Kruskal-Wallis test and Dunn test (post hoc) were used. Significance level was set at 5%. RESULTS: There were no complications (oedema, alveolitis, etc.) in any of the patients of the study. The results showed that both methods caused shallow pocket depth (P > 0.05) and there were no statistically significant differences between the flap techniques (P > 0.05). Flap design was not an important factor affecting the periodontal status of the second molar. CONCLUSION: The decision to use any of the various flap designs for access to mandibular third molars should be based on operator preference rather than on the assumption that periodontal health of the adjacent second molar will be improved. FAU - Chaves, A J P AU - Chaves AJ AD - Department of Maxillofacial Surgery, EAP, APCD, Piracicaba, SP, Brazil. FAU - Nascimento, L R AU - Nascimento LR FAU - Costa, M E G AU - Costa ME FAU - Franz-Montan, M AU - Franz-Montan M FAU - Oliveira-Júnior, P A AU - Oliveira-Júnior PA FAU - Groppo, F C AU - Groppo FC LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Int J Dent Hyg JT - International journal of dental hygiene JID - 101168070 SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolectomy/adverse effects/methods MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Periodontal Pocket/*etiology MH - Statistics, Nonparametric MH - *Surgical Flaps MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/complications/*surgery EDAT- 2008/04/17 09:00 MHDA- 2008/05/20 09:00 CRDT- 2008/04/17 09:00 PHST- 2008/04/17 09:00 [pubmed] PHST- 2008/05/20 09:00 [medline] PHST- 2008/04/17 09:00 [entrez] AID - IDH297 [pii] AID - 10.1111/j.1601-5037.2008.00297.x [doi] PST - ppublish SO - Int J Dent Hyg. 2008 May;6(2):123-8. doi: 10.1111/j.1601-5037.2008.00297.x. PMID- 22048601 OWN - NLM STAT- MEDLINE DCOM- 20120405 LR - 20111103 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 22 IP - 3 DP - 2011 May-Jun TI - Tooth in the line of fracture: its prognosis and its effects on healing. PG - 495-6 LID - 10.4103/0970-9290.87083 [doi] AB - AIMS AND OBJECTIVE: The aim of this prospective study was to compare the postoperative results of mandibular angle fracture cases treated by open reduction and internal fixation wherein the third molar in the line of fracture was preserved in one group while it was extracted in the second group. MATERIALS AND METHODS: Group I consisted of 30 patients in which the mandibular third molar in the line of fracture was preserved and group II consisted of 24 patients in which it was extracted following specific criteria. Various parameters like postoperative healing, infection, occlusion, tooth vitality, and mobility were graded numerically. Statistical analysis using a t-test was done. Data were expressed as mean±SD and a probability (P) value of <0.05 was considered significant. RESULTS: The presence of infection with pain and tenderness was higher in group I. Osteogenesis was higher in group I till the end of the third week but the difference was not significant later. Discrepancy in occlusion was more in group II. Mobility of tooth decreased and status of periodontal tissue improved significantly with time. In the tooth involved, the return of vitality and decrease in pain/tenderness was significant after 1 week and continued till 24 weeks to normalcy. Two teeth showed mild root resorbtion and none showed ankylosis. CONCLUSION: Postoperative occlusal discrepancy is less but infection is higher when the tooth in the line of fracture is preserved as compared to when it is removed. More than half of the teeth in the fracture line show complete recovery within a period of 6 months to 1 year. Despite the risk of an increase in the rate of complications, the tooth in the line of fracture should be preserved for its merits. FAU - Rai, Sachin AU - Rai S AD - Postgraduate Institute of Medical Education and Research, Chandigarh, India. drraisachin@gmail.com FAU - Pradhan, Raghvendra AU - Pradhan R LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 SB - D MH - Adult MH - Female MH - Follow-Up Studies MH - Fracture Fixation, Internal/adverse effects/*methods MH - Humans MH - Male MH - Mandibular Fractures/complications/*surgery MH - Molar, Third/*surgery MH - *Tooth Extraction MH - Tooth Loss/*etiology MH - Treatment Outcome EDAT- 2011/11/04 06:00 MHDA- 2012/04/06 06:00 CRDT- 2011/11/04 06:00 PHST- 2011/11/04 06:00 [entrez] PHST- 2011/11/04 06:00 [pubmed] PHST- 2012/04/06 06:00 [medline] AID - IndianJDentRes_2011_22_3_495_87083 [pii] AID - 10.4103/0970-9290.87083 [doi] PST - ppublish SO - Indian J Dent Res. 2011 May-Jun;22(3):495-6. doi: 10.4103/0970-9290.87083. PMID- 19417877 OWN - NLM STAT- MEDLINE DCOM- 20090707 LR - 20210227 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 40 IP - 4 DP - 2009 Apr TI - Effects of ketoprofen and diclofenac potassium on blood coagulation tests after removal of third molars. PG - 321-5 AB - OBJECTIVE: Nonsteroidal anti-inflammatory drugs inhibit platelet aggregation and increase bleeding time; however, they are required to control pain and swelling following dental surgery. The objective of this study was to evaluate possible changes on blood coagulation tests by using ketoprofen and diclofenac potassium after removal of mandibular third molars. METHOD AND MATERIALS: Fifty-one subjects between 16 and 30 years old, with no history of gastrointestinal disorders or allergy to anti-inflammatory components, were randomly assigned to 2 groups: 27 patients received 50 mg of ketoprofen, and 24 patients received 25 mg of diclofenac potassium. Subjects started the oral medication 2 hours before surgery and continued taking it every 8 hours for 5 days. Blood samples were collected preoperatively and on the final day of the drug regime to evaluate prothrombin time, activated partial thromboplastin time, clot retraction, and platelet count. RESULTS: Student t test for matched pairs did not show a significant difference between pre- and posttreatment variables for both anti-inflammatory drugs. CONCLUSION: These results suggest that the safety of ketoprofen and diclofenac potassium is comparable to their anticoagulation effect. FAU - Naclério-Homem, Maria da Graça AU - Naclério-Homem MG AD - Department of Oral and Maxillofacial Surgery, Prosthodontics, and Traumatology, Faculty of Dentistry, University of São Paulo, São Paulo, Brazil. mgracanh@usp.br FAU - Deboni, Maria Christina Zindel AU - Deboni MC FAU - Rapoport, Abrăo AU - Rapoport A FAU - Chin, Veronica Kei Len AU - Chin VK LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Platelet Aggregation Inhibitors) RN - 144O8QL0L1 (Diclofenac) RN - 90Y4QC304K (Ketoprofen) SB - D MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Blood Coagulation/*drug effects MH - Blood Coagulation Tests MH - Diclofenac/*administration & dosage MH - Female MH - Humans MH - Ketoprofen/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/drug therapy MH - Platelet Aggregation Inhibitors/administration & dosage MH - Postoperative Care MH - Premedication MH - *Tooth Extraction MH - Young Adult EDAT- 2009/05/07 09:00 MHDA- 2009/07/08 09:00 CRDT- 2009/05/07 09:00 PHST- 2009/05/07 09:00 [entrez] PHST- 2009/05/07 09:00 [pubmed] PHST- 2009/07/08 09:00 [medline] AID - 840110 [pii] PST - ppublish SO - Quintessence Int. 2009 Apr;40(4):321-5. PMID- 12778623 OWN - NLM STAT- MEDLINE DCOM- 20030801 LR - 20061115 IS - 0164-9442 (Print) IS - 0164-9442 (Linking) VI - 93 IP - 4 DP - 2003 Spring TI - The use of bovine porous bone mineral in combination with collagen membrane or autologous fibrinogen/fibronectin system for ridge preservation following tooth extraction. PG - 33-8 AB - Preservation of the alveolar ridge following tooth extraction is desirable since it facilitates placement of endosseous implants and may improve the adverse esthetics often associated with fixed partial dentures. The purpose of this study was to compare the clinical effectiveness of bovine porous bone mineral (BPBM) used as a graft material combined with either guided tissue regeneration (GTR) or with the autologous fibrinogen/fibronectin system (AFFS) in preserving alveolar ridges following tooth extraction. Twenty-six patients who required extraction of two or more anterior or bicuspid teeth participated in a split-mouth design study. Following tooth extraction and elevation of a buccal full thickness flap, sockets were filled with bovine porous bone mineral which was then covered with either a collagen membrane or mixed and covered with an AFFS system. An acrylic stent served as a reference point for measurements. Primary flap closure was achieved in all surgical sites, and reentry surgery was performed at 6 months. Reentry surgery showed that BPBM/GTR sites presented with [1] significantly more internal socket bone fill (6.04 +/- 0.21 mm vs. 4.98 +/- 0.26 mm), [2] less, although not statistically significant, resorption of alveolar bone height (0.23 +/- 0.28 mm vs. 0.3 +/- 0.21 mm), and [3] significantly less horizontal resorption of the alveolar bony ridge as compared to BPBM/AFFS (1.06 +/- 0.28 mm vs. 2.60 +/- 0.25 mm). This study suggests that treatment of extraction sockets with a combination of bovine porous bone mineral and guided tissue regeneration is of slightly more benefit in preserving alveolar ridge dimensions following tooth extraction than treatment with a combination of bovine porous bone mineral and the autologous fibrinogen/fibronectin system. FAU - Vasilic, Nikola AU - Vasilic N AD - University of Oklahoma College of Dentistry, USA. FAU - Henderson, Robin AU - Henderson R FAU - Jorgenson, Todd AU - Jorgenson T FAU - Sutherland, Edwin AU - Sutherland E FAU - Carson, Robert AU - Carson R LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Okla Dent Assoc JT - Journal - Oklahoma Dental Association JID - 7905263 RN - 0 (Fibrin Tissue Adhesive) RN - 0 (Fibronectins) RN - 0 (Membranes, Artificial) RN - 0 (Minerals) RN - 0 (Tissue Adhesives) RN - 9001-32-5 (Fibrinogen) RN - 9007-34-5 (Collagen) SB - D MH - Adult MH - Alveolar Process/pathology MH - Alveolar Ridge Augmentation/*methods MH - Animals MH - Bone Resorption/pathology MH - Bone Transplantation/*methods MH - Cattle MH - *Collagen MH - Female MH - Fibrin Tissue Adhesive/*therapeutic use MH - Fibrinogen/therapeutic use MH - Fibronectins/therapeutic use MH - Guided Tissue Regeneration, Periodontal MH - Humans MH - Male MH - Matched-Pair Analysis MH - *Membranes, Artificial MH - Minerals/*therapeutic use MH - Tissue Adhesives/*therapeutic use MH - *Tooth Extraction MH - Tooth Socket/surgery MH - Transplantation, Heterologous MH - Treatment Outcome EDAT- 2003/06/05 05:00 MHDA- 2003/08/02 05:00 CRDT- 2003/06/05 05:00 PHST- 2003/06/05 05:00 [pubmed] PHST- 2003/08/02 05:00 [medline] PHST- 2003/06/05 05:00 [entrez] PST - ppublish SO - J Okla Dent Assoc. 2003 Spring;93(4):33-8. PMID- 17577495 OWN - NLM STAT- MEDLINE DCOM- 20070724 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 65 IP - 7 DP - 2007 Jul TI - Pre-emptive analgesic effect of tramadol after mandibular third molar extraction: a pilot study. PG - 1315-20 AB - PURPOSE: We compared the efficacy of tramadol given before or immediately after surgical extraction of an impacted mandibular third molar under local anesthesia. MATERIALS AND METHODS: In this prospective, randomized, controlled, double-blind pilot study, 3 groups of 20 patients each were included: tramadol preoperative, 100 mg intramuscularly (IM) 1 hour before surgery (group A); tramadol postoperative, 100 mg IM immediately after surgery (group B); and saline (group C). We evaluated intensity of pain and analgesic consumption as was requested. RESULTS: The analgesic efficacy measured as complete relief of pain at 24 hours was 86% in the preemptive tramadol compared with 70% and 36% for postoperative tramadol administration and control group. A significant reduction in the consumption of analgesics was seen in preoperative group as compared with the postoperative and control groups. Adverse events were minimal and similar in all groups. CONCLUSIONS: This study suggests the preemptive use of tramadol as an alternative for the acute pain treatment after the removal of an impacted mandibular third molar carried out under local anesthesia. FAU - Pozos-Guillen, Amaury AU - Pozos-Guillen A AD - Department of Oral and Maxillofacial Surgery, Facultad de Estomatología, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico. FAU - Martinez-Rider, Ricardo AU - Martinez-Rider R FAU - Aguirre-Banuelos, Patricia AU - Aguirre-Banuelos P FAU - Perez-Urizar, Jose AU - Perez-Urizar J LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Opioid) RN - 39J1LGJ30J (Tramadol) SB - AIM SB - D SB - IM MH - Adult MH - Analgesics, Opioid/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Pilot Projects MH - Postoperative Care MH - Preanesthetic Medication MH - Statistics, Nonparametric MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Tramadol/*administration & dosage EDAT- 2007/06/20 09:00 MHDA- 2007/07/25 09:00 CRDT- 2007/06/20 09:00 PHST- 2006/02/15 00:00 [received] PHST- 2006/07/14 00:00 [revised] PHST- 2006/10/31 00:00 [accepted] PHST- 2007/06/20 09:00 [pubmed] PHST- 2007/07/25 09:00 [medline] PHST- 2007/06/20 09:00 [entrez] AID - S0278-2391(07)00349-7 [pii] AID - 10.1016/j.joms.2006.10.079 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2007 Jul;65(7):1315-20. doi: 10.1016/j.joms.2006.10.079. PMID- 33653320 OWN - NLM STAT- MEDLINE DCOM- 20210426 LR - 20210426 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 21 IP - 1 DP - 2021 Mar 2 TI - Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trial. PG - 91 LID - 10.1186/s12903-021-01451-0 [doi] LID - 91 AB - BACKGROUND: Serratiopeptidase has been clinically used in controlling surgical and non-surgical inflammatory conditions. This study was conducted to assess the therapeutic effect of Serratiopeptidase in patients undergoing surgical removal of impacted mandibular third molar. METHODS: This randomized clinical trial investigated the efficacy of Serratiopeptidase and Paracetamol after surgical removal of impacted third molar for 5 days (n = 67) as compared with an equivalent dose of placebo and Paracetamol (n = 66). Outcome measures were reported pain, trismus and swelling using Laskin method. All outcome measures were recorded on days 0, 1, 2, 4, and 5 post-surgeries. RESULTS: In this clinical trail 133 patients (mean age 23 years, 54% female) completed the study. Baseline characteristics were comparable across treatment groups. Serratiopeptidase significantly improved trismus compared with control on the 4(th) day (27.30 ± 7.3 mm and 32.06 ± 7.7 mm, respectively (P < 0.001) Swelling markedly improved, The distance from the lower edge of the earlobe to the midpoint of the symphysis for cases vs control were 111.49 ± 8.1 mm and 115.39 ± 9.9 mm, respectively (P < 0.001). Reported pain, showed no statistical significance difference. CONCLUSION: Serratiopeptidase resulted in better inflammation improvement than placebo over 5 days. Further studies are warranted to assess longer-term and clinical outcomes, as well as safety. CLINICAL RELEVANCE: Serratiopeptidase administered postoperatively helps in improving trismus and swelling after removal of impacted lower third molars. Trial registration The study was registered in ClinicalTrial.gov under the number NCT02493179. Registered 1st of June 2015, https://clinicaltrials.gov/ct2/results?cond=serratiopeptidase . FAU - Tamimi, Zaid AU - Tamimi Z AUID- ORCID: 0000-0001-7972-0331 AD - Department Oral Surgery and Oral Medicine, Jordan University of Science and Technology, Irbid, Jordan. zztamimi@just.edu.jo. FAU - Al Habashneh, Rola AU - Al Habashneh R AD - Department Periodontology, Jordan University of Science and Technology, Irbid, Jordan. FAU - Hamad, Islam AU - Hamad I AD - Department of Pharmacy, American University of Madaba, Amman, Jordan. FAU - Al-Ghazawi, Mutasim AU - Al-Ghazawi M AD - Department of Biopharmaceutics and Clinical Pharmacy, The University of Jordan, Amman, Jordan. FAU - Roqa'a, Ala' Abu AU - Roqa'a AA AD - The First for Research and Development LLC, Amman, Jordan. FAU - Kharashgeh, Hamza AU - Kharashgeh H AD - Department Oral Surgery and Oral Medicine, Jordan University of Science and Technology, Irbid, Jordan. LA - eng SI - ClinicalTrials.gov/NCT02493179 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20210302 TA - BMC Oral Health JT - BMC oral health JID - 101088684 RN - EC 3.4.- (Peptide Hydrolases) RN - NL053ABE4J (serratiopeptidase) SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Male MH - *Molar, Third/surgery MH - Pain, Postoperative/drug therapy/prevention & control MH - Peptide Hydrolases MH - Tooth Extraction/adverse effects MH - *Tooth, Impacted/surgery MH - Treatment Outcome MH - Trismus/etiology/prevention & control MH - Young Adult PMC - PMC7927242 OTO - NOTNLM OT - *Inflammation OT - *Molar OT - *Surgery OT - *Swelling OT - *Third OT - *Trismus COIS- Dr Tamimi, Prof Alhabashneh, Dr Hamad, Prof al-Ghazawi, PH Abu Roqa’a and Dr Kharashgeh declare that they have no competing interests. EDAT- 2021/03/04 06:00 MHDA- 2021/04/27 06:00 CRDT- 2021/03/03 05:33 PHST- 2020/05/14 00:00 [received] PHST- 2021/02/21 00:00 [accepted] PHST- 2021/03/03 05:33 [entrez] PHST- 2021/03/04 06:00 [pubmed] PHST- 2021/04/27 06:00 [medline] AID - 10.1186/s12903-021-01451-0 [pii] AID - 1451 [pii] AID - 10.1186/s12903-021-01451-0 [doi] PST - epublish SO - BMC Oral Health. 2021 Mar 2;21(1):91. doi: 10.1186/s12903-021-01451-0. PMID- 20116700 OWN - NLM STAT- MEDLINE DCOM- 20100217 LR - 20100201 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 68 IP - 2 DP - 2010 Feb TI - Influence of primary and secondary closure of surgical wound after impacted mandibular third molar removal on postoperative pain and swelling--a comparative and split mouth study. PG - 309-12 LID - 10.1016/j.joms.2009.04.060 [doi] AB - PURPOSE: The purpose of the present study was to compare the influence of primary and secondary closure of the surgical wound on postoperative pain and swelling after removal of impacted mandibular third molars. MATERIALS AND METHODS: A total of 93 patients with bilaterally impacted mandibular third molars were included in the present study. All the patients underwent surgical removal of the bilaterally impacted teeth at the same appointment. Primary closure (group I) was performed on 1 side and secondary closure (group II) was performed on the other side. All the patients were assessed for pain and swelling using the visual analog scale, and the data were collected and analyzed with the paired t test after 7 days. RESULTS: The swelling in group I was greater than that in group II, with a statistically significant difference (P < .001). The pain was worse in group I than in group II; a difference that also was statistically significant (P < .05). Alveolar osteitis occurred in 4 patients (4.3%) in group I and 3 patients (3.2%) in group II. CONCLUSION: Our results have shown that the patients in the secondary closure group had a significantly lesser amount of pain and swelling postoperatively than the primary closure group. CI - Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Danda, Anil Kumar AU - Danda AK AD - Department of Oral and Maxillofacial Surgery, Saveetha University, Chennai, India. anilomfs@gmail.com FAU - Krishna Tatiparthi, Murali AU - Krishna Tatiparthi M FAU - Narayanan, Vinod AU - Narayanan V FAU - Siddareddi, Avinash AU - Siddareddi A LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20100115 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Suture Techniques MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Wound Healing MH - Young Adult EDAT- 2010/02/02 06:00 MHDA- 2010/02/18 06:00 CRDT- 2010/02/02 06:00 PHST- 2008/11/23 00:00 [received] PHST- 2009/01/17 00:00 [revised] PHST- 2009/04/21 00:00 [accepted] PHST- 2010/02/02 06:00 [entrez] PHST- 2010/02/02 06:00 [pubmed] PHST- 2010/02/18 06:00 [medline] AID - S0278-2391(09)00559-X [pii] AID - 10.1016/j.joms.2009.04.060 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2010 Feb;68(2):309-12. doi: 10.1016/j.joms.2009.04.060. Epub 2010 Jan 15. PMID- 21208086 OWN - NLM STAT- MEDLINE DCOM- 20110425 LR - 20110106 IS - 1945-7103 (Electronic) IS - 0003-3219 (Linking) VI - 81 IP - 2 DP - 2011 Mar TI - Does a chitosan-containing dentifrice prevent demineralization around orthodontic brackets? PG - 319-25 LID - 10.2319/062910-359.1 [doi] AB - OBJECTIVE: To test the null hypothesis that there is no significant difference between the chitosan-containing and conventional nonfluoridated dentifrices in inhibition of enamel demineralization around orthodontic brackets. MATERIALS AND METHODS: Sixteen orthodontic patients who were scheduled to have extraction of four first premolars for orthodontic reasons were divided into two groups after the power of the study was estimated. Patients in the experimental group were instructed to use chitosan-containing dentifrice (AloeDent), and patients in the control group were instructed to use nonfluoridated dentifrice (Sensodyne Mint). After 60 days, the teeth were extracted and longitudinally sectioned. The demineralization was assessed by cross-sectional microhardness. The determinations were made at the bracket edge cementing limits and at occlusal and cervical points, 100 µm and 200 µm away from the edge. In all these positions, indentations were made at depths of 10, 20, 30, 50, 70, and 90 µm from the enamel surface. Analysis of variance (ANOVA) and Tukey test were used for statistical evaluation at P < .05 level. RESULTS: ANOVA showed statistically significant differences for the factors of dentifrice type, position, and depth (P  =  .000). Statistically significant differences for microhardness values between two tested dentifrices were observed up to 20 µm of depth from the enamel surface (P < .05). Lower microhardness values were found for nonfluoridated dentifrice. Significant microhardness differences were also determined between materials at occlusal and cervical 0 µm positions (P < .05). At these positions, chitosan-containing dentifrice showed lower demineralization than the control. CONCLUSION: Chitosan-containing dentifrice may reduce the enamel decalcification found in patients with poor oral hygiene. The null hypothesis is rejected. FAU - Uysal, Tancan AU - Uysal T AD - Erciyes University, Department of Orthodontics, Kayseri, Turkey. tancanuysal@yahoo.com FAU - Akkurt, Meltem Derya AU - Akkurt MD FAU - Amasyali, Mihri AU - Amasyali M FAU - Ozcan, Suat AU - Ozcan S FAU - Yagci, Ahmet AU - Yagci A FAU - Basak, Feridun AU - Basak F FAU - Sagdic, Deniz AU - Sagdic D LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Angle Orthod JT - The Angle orthodontist JID - 0370550 RN - 0 (Dentifrices) RN - 9012-76-4 (Chitosan) SB - D SB - IM MH - Analysis of Variance MH - Chitosan/*therapeutic use MH - Dentifrices/chemistry/*therapeutic use MH - Hardness MH - Humans MH - Observer Variation MH - Orthodontic Brackets/*adverse effects MH - Statistics, Nonparametric MH - Tooth Demineralization/etiology/*prevention & control EDAT- 2011/01/07 06:00 MHDA- 2011/04/26 06:00 CRDT- 2011/01/07 06:00 PHST- 2011/01/07 06:00 [entrez] PHST- 2011/01/07 06:00 [pubmed] PHST- 2011/04/26 06:00 [medline] AID - 10.2319/062910-359.1 [doi] PST - ppublish SO - Angle Orthod. 2011 Mar;81(2):319-25. doi: 10.2319/062910-359.1. PMID- 25277807 OWN - NLM STAT- MEDLINE DCOM- 20150814 LR - 20151119 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 43 IP - 12 DP - 2014 Dec TI - Thermographic monitoring of wound healing and oral health-related quality of life in patients treated with laser (aPDT) after impacted mandibular third molar removal. PG - 1503-8 LID - S0901-5027(14)00336-1 [pii] LID - 10.1016/j.ijom.2014.09.003 [doi] AB - The objective of this study was to assess the impact of low-level laser therapy on wound swelling, wound temperature changes, and oral health-related quality of life (OHRQoL) after surgical removal of impacted lower third molars. Forty patients with impacted lower third molars requiring surgical removal participated in this study; all were Pell-Gregory class IIB or IIC. The patients were divided randomly into two groups for post-extraction therapy. One group received antimicrobial photodynamic therapy (aPDT) and the other received no additional therapy (placebo group). Temperature measurements were done using an infrared thermographic camera on days 3 and 7 postoperative. OHRQoL was assessed in both groups on day 7 using the Oral Health Impact Profile questionnaire translated into Croatian (OHIP-14-CRO). Prior to surgical treatment, there was no difference in patient characteristics between the two groups. A significantly lower temperature and less wound swelling were recorded on day 3 postoperative in the aPDT group compared to the control group (P<0.001). Participants in the aPDT group also had significantly lower OHIP-14-CRO summary scores (P<0.01). The present study showed beneficial effects of the aPDT modality of low-level laser therapy: postoperative wound swelling was reduced and wound temperature decreased, and OHRQoL was better through the 7-day postoperative period in comparison to the placebo group. CI - Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Batinjan, G AU - Batinjan G AD - Department of Oral Surgery, School of Dental Medicine and Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia. Electronic address: gbatinjan@sfzg.hr. FAU - Zore, Z AU - Zore Z AD - Department of Surgical Oncology, Clinical Hospital Sisters of Mercy, Zagreb, Croatia. FAU - Čelebić, A AU - Čelebić A AD - Department of Prosthodontics, School of Dental Medicine and Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia. FAU - Papić, M AU - Papić M AD - High Business School Libertas, University of Zagreb, Zagreb, Croatia. FAU - Gabrić Pandurić, D AU - Gabrić Pandurić D AD - Department of Oral Surgery, School of Dental Medicine and Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia. FAU - Filipović Zore, I AU - Filipović Zore I AD - Department of Oral Surgery, School of Dental Medicine and Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20140929 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adult MH - Female MH - Humans MH - Lasers, Semiconductor/*therapeutic use MH - *Low-Level Light Therapy MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Postoperative Complications/*prevention & control MH - *Quality of Life MH - Thermography/*methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Wound Healing/*radiation effects OTO - NOTNLM OT - diode laser OT - quality of life OT - thermography OT - third molar extraction EDAT- 2014/10/04 06:00 MHDA- 2015/08/15 06:00 CRDT- 2014/10/04 06:00 PHST- 2013/12/13 00:00 [received] PHST- 2014/05/10 00:00 [revised] PHST- 2014/09/05 00:00 [accepted] PHST- 2014/10/04 06:00 [entrez] PHST- 2014/10/04 06:00 [pubmed] PHST- 2015/08/15 06:00 [medline] AID - S0901-5027(14)00336-1 [pii] AID - 10.1016/j.ijom.2014.09.003 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2014 Dec;43(12):1503-8. doi: 10.1016/j.ijom.2014.09.003. Epub 2014 Sep 29. PMID- 14699540 OWN - NLM STAT- MEDLINE DCOM- 20040203 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 62 IP - 1 DP - 2004 Jan TI - Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? PG - 3-8; discussion 9 AB - PURPOSE: We evaluated the need for prophylactic postoperative oral antibiotic treatment in the removal of asymptomatic third molars. MATERIALS AND METHODS: In a prospective study of more than 30 months, a total of 528 impacted lower third molars were surgically removed in 288 patients. All patients were referred to our department by a dentist or a general practitioner. No patient showed any sign of pain, inflammation, or swelling at the time of removal. Three groups were established. In the first group, antibiotic treatment with amoxicillin/clavulanic acid as an oral medication was carried out for 5 days postoperatively. In the second group, we used clindamycin. In the third group, the patients received no antibiotic treatment. Clinical and radiologic factors were recorded for each case, and the rationale for assigning the patients to the groups was strictly random. The surgical technique was the same in all cases, and the follow-up period was 4 weeks. Parameters that were evaluated were pain, differences in mouth opening, infection, the occurrence of dry socket, and adverse postoperative side effects. RESULTS: We could not find any significant difference between the 3 groups regarding the evaluated parameters, but in 69.6% of the patients with dry socket, the teeth were partially erupted, which showed a significant difference. CONCLUSIONS: The results of our study show that specific postoperative oral prophylactic antibiotic treatment after the removal of lower third molars does not contribute to a better wound healing, less pain, or increased mouth opening and could not prevent the cases of inflammatory problems after surgery, respectively, and therefore is not recommended for routine use. FAU - Poeschl, Paul W AU - Poeschl PW AD - University Hospital for Cranio-Maxillofacial and Oral Surgery, Vienna Medical School, Vienna, Austria. maxillofacials@hotmail.com FAU - Eckel, Doris AU - Eckel D FAU - Poeschl, Ellen AU - Poeschl E LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Bacterial Agents) RN - 3U02EL437C (Clindamycin) RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) SB - AIM SB - D SB - IM CIN - Evid Based Dent. 2005;6(1):10. PMID: 15789042 CIN - J Evid Based Dent Pract. 2005 Mar;5(1):14-5. PMID: 17138317 MH - Adolescent MH - Adult MH - Amoxicillin-Potassium Clavulanate Combination/*therapeutic use MH - Anti-Bacterial Agents/*therapeutic use MH - Antibiotic Prophylaxis/methods/*statistics & numerical data MH - Clindamycin/*therapeutic use MH - Dry Socket/prevention & control MH - Humans MH - Mandible MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Care/methods MH - Prospective Studies MH - Surgical Wound Infection/prevention & control MH - *Tooth Extraction EDAT- 2003/12/31 05:00 MHDA- 2004/02/05 05:00 CRDT- 2003/12/31 05:00 PHST- 2003/12/31 05:00 [pubmed] PHST- 2004/02/05 05:00 [medline] PHST- 2003/12/31 05:00 [entrez] AID - S0278239103009364 [pii] AID - 10.1016/j.joms.2003.05.004 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2004 Jan;62(1):3-8; discussion 9. doi: 10.1016/j.joms.2003.05.004. PMID- 22793965 OWN - NLM STAT- MEDLINE DCOM- 20150713 LR - 20120716 IS - 1806-907X (Electronic) IS - 0034-7094 (Linking) VI - 62 IP - 4 DP - 2012 Jul TI - Assessment of preemptive analgesia efficacy in surgical extraction of third molars. PG - 502-10 LID - 10.1016/S0034-7094(12)70148-4 [doi] AB - BACKGROUND AND OBJECTIVES: Literature on preemptive analgesia is controversial. Reliability of results and difficult reproducibility of research contribute for non-elucidation of the subject. The aim of this study is to test the efficacy of oral ketoprofen (150 mg) preemptively administrated two days before third molar surgery, compared with postoperative administration in the same patient. METHODS: Thirteen patients underwent surgical removal of bilateral third molar in two separate procedures. In a random and double blind procedure, oral ketoprofen 150 mg was administered every 12 hours two days before surgery and, after the procedure, the same drug was administered for three days. On the other side, a control (placebo) was used orally every 12 hours two days before surgery and, after the procedure, ketoprofen 150 mg was administered every 12 hours for three days. Postoperative pain was assessed by visual analogue scale, nominal scale, and amount of rescue analgesics consumed. RESULTS: There was no statistically significant difference in postoperative pain between the preemptive treatment and control. CONCLUSION: In this experimental model, preemptive analgesia was not effective in reducing postoperative pain in surgical extraction of third molar compared with the postoperative administration of the same drug. CI - Copyright © 2012 Elsevier Editora Ltda. All rights reserved. FAU - Liporaci Junior, Jorge Luiz Jacob AU - Liporaci Junior JL AD - Maxillofacial Oral Surgeon; PhD, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, SP, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Brazil TA - Rev Bras Anestesiol JT - Revista brasileira de anestesiologia JID - 0401316 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 90Y4QC304K (Ketoprofen) SB - IM MH - Adolescent MH - Adult MH - *Analgesia MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Ketoprofen/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - *Premedication MH - Reproducibility of Results MH - *Tooth Extraction MH - Young Adult EDAT- 2012/07/17 06:00 MHDA- 2015/07/15 06:00 CRDT- 2012/07/17 06:00 PHST- 2011/07/17 00:00 [received] PHST- 2011/09/12 00:00 [accepted] PHST- 2012/07/17 06:00 [entrez] PHST- 2012/07/17 06:00 [pubmed] PHST- 2015/07/15 06:00 [medline] AID - S0034-7094(12)70148-4 [pii] AID - 10.1016/S0034-7094(12)70148-4 [doi] PST - ppublish SO - Rev Bras Anestesiol. 2012 Jul;62(4):502-10. doi: 10.1016/S0034-7094(12)70148-4. PMID- 22033341 OWN - NLM STAT- MEDLINE DCOM- 20120813 LR - 20120312 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 41 IP - 3 DP - 2012 Mar TI - Influence of a pedicle flap design on acute postoperative sequelae after lower third molar removal. PG - 371-5 LID - 10.1016/j.ijom.2011.08.006 [doi] AB - Pain, swelling, trismus, and alveolar osteitis often occur after removal of impacted third molar teeth. To minimize these complications a number of mucoperiosteal flap designs have been advocated, but, to date, a pedicle flap design has not been evaluated. In a randomized prospective split mouth study, 52 participants had bilateral symmetrically impacted mandibular third molars removed over two sessions. A buccal envelope or pedicle flap was randomly assigned to the left or right third molar site. Pre-and postoperative pain and swelling were recorded using a standardized visual analogue scale, trismus was measured as the maximum inter-incisal opening distance in millimetres and dry socket was assessed clinically. Greater continuous pain, pain on maximum opening, and oro-facial swelling were recorded with the pedicle flap design. Continuous pain resolved significantly faster with this flap design (p<0.05). Trismus was similar for both flap designs (p>0.05). Five cases of alveolar osteitis occurred with the envelope flap whilst no cases developed with the pedicle flap, but the incidence was too small for statistical analysis. The pedicle flap improved some aspects of postoperative pain experience and reduced the incidence of alveolar osteitis, but further investigation with a larger sample size is required to evaluate its significance. CI - Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Goldsmith, Sam M AU - Goldsmith SM AD - Department of Oral Diagnostic and Surgical Sciences, University of Otago, Dunedin, New Zealand. FAU - De Silva, Rohana Kumara AU - De Silva RK FAU - Tong, Darryl C AU - Tong DC FAU - Love, Robert M AU - Love RM LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20111026 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Dry Socket/etiology MH - Edema/classification/etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/etiology MH - Pericoronitis/etiology MH - *Postoperative Complications MH - Prospective Studies MH - Surgical Flaps/*classification/pathology MH - Surgical Wound Dehiscence/etiology MH - Surgical Wound Infection/etiology MH - Tooth Extraction/*methods MH - Tooth Socket/surgery MH - Tooth, Impacted/surgery MH - Trismus/etiology MH - Young Adult EDAT- 2011/10/29 06:00 MHDA- 2012/08/14 06:00 CRDT- 2011/10/29 06:00 PHST- 2010/06/30 00:00 [received] PHST- 2011/04/21 00:00 [revised] PHST- 2011/08/31 00:00 [accepted] PHST- 2011/10/29 06:00 [entrez] PHST- 2011/10/29 06:00 [pubmed] PHST- 2012/08/14 06:00 [medline] AID - S0901-5027(11)01406-8 [pii] AID - 10.1016/j.ijom.2011.08.006 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2012 Mar;41(3):371-5. doi: 10.1016/j.ijom.2011.08.006. Epub 2011 Oct 26. PMID- 9241922 OWN - NLM STAT- MEDLINE DCOM- 19970904 LR - 20190831 IS - 0045-0421 (Print) IS - 0045-0421 (Linking) VI - 42 IP - 3 DP - 1997 Jun TI - Inferior alveolar nerve damage following removal of mandibular third molar teeth. A prospective study using panoramic radiography. PG - 149-52 AB - Permanent alteration of sensation in the lip after the removal of mandibular third molar teeth is an unusual but important complication. Studies have been performed to assess the risk of nerve damage but most of these have been retrospective and poorly controlled. This prospective trial predicted the outcome of altered sensation prior to surgery based on assessment of a panoramic radiograph and correlated this with the result postoperatively in the consecutive removal of 479 third molar teeth. Results indicated that 5.2 per cent had transient alteration in sensation but only one patient (0.2 per cent) had prolonged anaesthesia. As 94.8 per cent of teeth extracted had no neurological sequelae the figures for prediction were skewed and a kappa statistical analysis of 0.27 illustrated a fair level of agreement between prediction and outcome. This study supports previously reported levels of neurological damage and confirms that panoramic radiography is the optimum method for radiological assessment for mandibular third molar teeth prior to their removal. FAU - Smith, A C AU - Smith AC AD - School of Dental Science, University of Melbourne. FAU - Barry, S E AU - Barry SE FAU - Chiong, A Y AU - Chiong AY FAU - Hadzakis, D AU - Hadzakis D FAU - Kha, S L AU - Kha SL FAU - Mok, S C AU - Mok SC FAU - Sable, D L AU - Sable DL LA - eng PT - Journal Article PL - Australia TA - Aust Dent J JT - Australian dental journal JID - 0370612 SB - D SB - IM MH - Adolescent MH - Adult MH - Confidence Intervals MH - Female MH - Follow-Up Studies MH - Forecasting MH - Humans MH - Incidence MH - Lip Diseases/etiology MH - Male MH - Mandible/*diagnostic imaging MH - Mandibular Nerve/diagnostic imaging MH - Molar, Third/diagnostic imaging/*surgery MH - Prevalence MH - Prospective Studies MH - *Radiography, Panoramic MH - Risk Factors MH - Sensation Disorders/etiology MH - Sensitivity and Specificity MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - *Trigeminal Nerve Injuries EDAT- 1997/06/01 00:00 MHDA- 1997/06/01 00:01 CRDT- 1997/06/01 00:00 PHST- 1997/06/01 00:00 [pubmed] PHST- 1997/06/01 00:01 [medline] PHST- 1997/06/01 00:00 [entrez] AID - 10.1111/j.1834-7819.1997.tb00111.x [doi] PST - ppublish SO - Aust Dent J. 1997 Jun;42(3):149-52. doi: 10.1111/j.1834-7819.1997.tb00111.x. PMID- 17178488 OWN - NLM STAT- MEDLINE DCOM- 20070206 LR - 20181201 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 103 IP - 1 DP - 2007 Jan TI - Effect estimates and methodological quality of randomized controlled trials about prevention of alveolar osteitis following tooth extraction: a systematic review. PG - 8-15 AB - OBJECTIVE: To systematically review the scientific evidence derived from randomized controlled trials (RCT) about prevention of alveolar osteitis (AO). STUDY DESIGN: Literature searches were conducted to locate RCTs about prevention of AO. The RCTs were scrutinized for methodological details and categorized according to the preventive intervention studied. Data were analyzed in relation to the frequency of AO. Absolute risk reductions (ARR), and numbers needed to treat were calculated with 95% confidence limits. RESULTS: There was a wide variation in the design and quality of the RCTs (N = 32). The greatest risk reduction for AO was seen for local treatment with tetracycline (ARR, 12%-31%). For a majority of the preventive interventions, the evidence was absent or inconclusive. CONCLUSIONS: Local treatment with tetracycline, and also 0.12% chlorhexidine rinsing preoperatively and 7 days postoperatively, seem to have significant and clinically relevant preventive effect on AO following surgical removal of lower third molars. FAU - Hedström, Lennart AU - Hedström L AD - Public Dental Services, Varberg, Sweden. FAU - Sjögren, Petteri AU - Sjögren P LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20060424 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anti-Bacterial Agents) RN - 0 (Anti-Infective Agents, Local) RN - 0 (Antifibrinolytic Agents) RN - 0 (Parabens) RN - F8VB5M810T (Tetracycline) RN - R4KO0DY52L (Chlorhexidine) RN - Z8IX2SC1OH (propylparaben) SB - D SB - IM CIN - Evid Based Dent. 2007;8(2):43. PMID: 17589485 MH - Anti-Bacterial Agents/adverse effects/therapeutic use MH - Anti-Infective Agents, Local/adverse effects/therapeutic use MH - Antifibrinolytic Agents/therapeutic use MH - Chlorhexidine/adverse effects/therapeutic use MH - Dry Socket/drug therapy/*prevention & control MH - Humans MH - Parabens/therapeutic use MH - Randomized Controlled Trials as Topic/standards MH - Tetracycline/adverse effects/therapeutic use MH - Tooth Extraction/*adverse effects RF - 48 EDAT- 2006/12/21 09:00 MHDA- 2007/02/07 09:00 CRDT- 2006/12/21 09:00 PHST- 2005/11/09 00:00 [received] PHST- 2005/12/19 00:00 [revised] PHST- 2006/01/04 00:00 [accepted] PHST- 2006/12/21 09:00 [pubmed] PHST- 2007/02/07 09:00 [medline] PHST- 2006/12/21 09:00 [entrez] AID - S1079-2104(06)00005-9 [pii] AID - 10.1016/j.tripleo.2006.01.007 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jan;103(1):8-15. doi: 10.1016/j.tripleo.2006.01.007. Epub 2006 Apr 24. PMID- 28987483 OWN - NLM STAT- MEDLINE DCOM- 20190815 LR - 20190815 IS - 1943-4723 (Electronic) IS - 0002-8177 (Linking) VI - 148 IP - 12 DP - 2017 Dec TI - Efficacy of adjuvant laser therapy in reducing postsurgical complications after the removal of impacted mandibular third molars: A systematic review update and meta-analysis. PG - 887-902.e4 LID - S0002-8177(17)30602-5 [pii] LID - 10.1016/j.adaj.2017.06.043 [doi] AB - BACKGROUND: The authors updated a previously published systematic review to assess the effects of low-level laser therapy (LLLT) on reducing complications after the removal of impacted mandibular third molars. TYPES OF STUDIES REVIEWED: The authors searched for randomized clinical trials in which the investigators evaluated the efficacy of LLLT compared with that of placebo or no treatment. Two reviewers independently screened studies, extracted data, and assessed risk of bias. The authors used random effects model meta-analysis and the Grading of Recommendations Assessment, Development and Evaluation approach to rate the certainty of evidence. RESULTS: The authors included 21 studies. There was low-certainty evidence that LLLT results in less pain at 2 days after surgery (mean difference [MD], -1.42 on a 10 point scale; 95% confidence interval [CI], -2.18 to -0.67) and moderate certainty that it results in negligibly less pain at 7 days (MD, -0.59; 95% CI, -0.96 to -0.22); moderate-certainty evidence that LLLT has a negligible benefit on reducing trismus at 2 days (MD, -3.42 millimeters; 95% CI, -5.34 to -1.50) and at 7 days after surgery (MD, -2.30 mm; 95% CI, -3.96 to -0.64); lastly, there was moderate-certainty evidence that LLLT results in less postoperative swelling at 2 days (standardized MD, -0.82; 95% CI, -1.28 to -0.35) and low-certainty evidence that LLLT results in negligibly less postoperative swelling at 7 days after surgery (standardized MD, -0.17; 95% CI, -0.4 to 0.07). Low-quality evidence suggests that LLLT will not cause adverse effects. CONCLUSIONS AND PRACTICAL IMPLICATIONS: LLLT probably has negligible benefits but may not result in adverse events. Evidence does not support the use of LLLT in clinical practice to reduce complications after impacted mandibular third-molar surgical extractions. CI - Copyright © 2017 American Dental Association. Published by Elsevier Inc. All rights reserved. FAU - Dawdy, Jamie AU - Dawdy J FAU - Halladay, Jillian AU - Halladay J FAU - Carrasco-Labra, Alonso AU - Carrasco-Labra A FAU - Araya, Ignacio AU - Araya I FAU - Yanine, Nicolas AU - Yanine N FAU - Brignardello-Petersen, Romina AU - Brignardello-Petersen R LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20171005 PL - England TA - J Am Dent Assoc JT - Journal of the American Dental Association (1939) JID - 7503060 MH - Humans MH - *Low-Level Light Therapy MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Postoperative Complications/*prevention & control MH - Randomized Controlled Trials as Topic MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - *Impacted mandibular third molar OT - *pain OT - *postsurgical complications OT - *swelling OT - *systematic review OT - *trismus EDAT- 2017/10/11 06:00 MHDA- 2019/08/16 06:00 CRDT- 2017/10/09 06:00 PHST- 2017/06/06 00:00 [received] PHST- 2017/06/22 00:00 [accepted] PHST- 2017/10/11 06:00 [pubmed] PHST- 2019/08/16 06:00 [medline] PHST- 2017/10/09 06:00 [entrez] AID - S0002-8177(17)30602-5 [pii] AID - 10.1016/j.adaj.2017.06.043 [doi] PST - ppublish SO - J Am Dent Assoc. 2017 Dec;148(12):887-902.e4. doi: 10.1016/j.adaj.2017.06.043. Epub 2017 Oct 5. PMID- 18600358 OWN - NLM STAT- MEDLINE DCOM- 20080721 LR - 20181113 IS - 1865-1550 (Print) IS - 1865-1550 (Linking) VI - 12 IP - 1 DP - 2008 May TI - Comparison of corticosteroids and rubber drain for reduction of sequelae after third molar surgery. PG - 29-33 LID - 10.1007/s10006-008-0096-6 [doi] AB - INTRODUCTION: For reducing edema, trismus, and pain after impacted tooth surgery, some protocols are proposed but their relative effectiveness is controversial. PURPOSE: The goal of this study was to evaluate and compare the effects of corticosteroids and rubber drain on the postoperative complications of impacted molar surgery. PATIENTS AND METHODS: This study was carried out on 22 patients with bilateral symmetrical mandibular impacted third molars. For surgical removal of impacted teeth on one side of these patients, either rubber drain (11 cases) or perioperative corticosteroids (11 cases) were used (study group). The contralateral impacted teeth were removed routinely without using any drug or drain (control group). Facial edema, trismus, and pain perception of the study and control groups were recorded on the second and seventh postoperative days. RESULTS AND DISCUSSION: This study showed that perioperative steroids reduce the trismus, facial swelling, and the severity of pain after third molar surgery. This study also revealed that the use of the drain reduces facial pain and trismus but has no effect on the facial swelling after impacted tooth surgery. Comparing the steroid and drain groups, we found that perioperative corticosteroids are more effective than the surgical drain in reducing postoperative pain and edema, but their effects on trismus are similar. FAU - Zandi, Mohammad AU - Zandi M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hamedan University of Medical Sciences, Shahid Fahmideh Street, Hamedan, Iran. zandi88m@yahoo.com LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adolescent MH - Adult MH - Dexamethasone/therapeutic use MH - Drainage/*instrumentation MH - Edema/etiology/prevention & control MH - Glucocorticoids/*therapeutic use MH - Humans MH - Methylprednisolone/therapeutic use MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology/prevention & control MH - Perioperative Care MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/etiology/prevention & control EDAT- 2008/07/05 09:00 MHDA- 2008/07/22 09:00 CRDT- 2008/07/05 09:00 PHST- 2008/07/05 09:00 [pubmed] PHST- 2008/07/22 09:00 [medline] PHST- 2008/07/05 09:00 [entrez] AID - 10.1007/s10006-008-0096-6 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2008 May;12(1):29-33. doi: 10.1007/s10006-008-0096-6. PMID- 10932022 OWN - NLM STAT- MEDLINE DCOM- 20001113 LR - 20181130 IS - 1366-5278 (Print) IS - 1366-5278 (Linking) VI - 4 IP - 15 DP - 2000 TI - The effectiveness and cost-effectiveness of prophylactic removal of wisdom teeth. PG - 1-55 AB - BACKGROUND: Removal of wisdom teeth is one of the most common surgical procedures performed in the UK. Little controversy surrounds the removal of impacted third molars when they are associated with pathological changes such as infection, non-restorable carious lesions, cysts, tumours, and destruction of adjacent teeth and bone. However, the justification for prophylactic removal of impacted third molars is less certain and has been debated for many years. OBJECTIVES: To provide a summary of existing evidence on prophylactic removal of impacted wisdom teeth, in terms of the incidence of surgical complications associated with prophylactic removal, and the morbidity associated with retention. METHODS: A systematic review of the research literature was undertaken. METHODS - DATA SOURCES: An existing review formed the basis of this report, and additional literature searches were undertaken, including searches of electronic databases (MEDLINE, 1984-99; EMBASE, 1984-99; Science Citation Index, Cochrane Controlled Trials Register, National Research Register; Database of Abstracts of Reviews of Effectiveness), paper sources (including Clinical Evidence), and web-based resources. Relevant organisations and professional bodies were contacted for further information. METHODS - STUDY SELECTION: Studies were selected for inclusion if they met the following criteria: (1) design - randomised controlled trials (RCTs), literature reviews, or decision analyses; (2) participants - people with unerupted or impacted third molars, or those undergoing surgical removal of third molars either as prophylaxis or due to associated pathological changes; (3) reported outcomes - either the pathological changes associated with retention of third molars, or post-operative complications following extraction. There were no language restrictions on study selection. METHODS - DATA EXTRACTION AND SYNTHESIS: Data from included studies were extracted into structured tables and individual study validity was assessed against methodological checklists. Data were summarised descriptively. Decisions relating to study selection, data extraction and validity assessment were made by two independent reviewers, and disagreements were resolved by discussion. For non-English papers, translators were recruited to assist with study selection and data extraction. RESULTS: Forty studies were included in the review: two RCTs, 34 literature reviews, and four decision analysis studies. One RCT in the UK focused on the effects of retained third molars on incisor crowding (predominantly a cosmetic problem) in patients who had previously undergone orthodontic treatment. The results of this trial suggested that the removal of third molars to prevent late incisor crowding cannot be justified. Another on-going RCT in Denmark compares the effects and costs of prophylactic removal of third molars with removal according to morbidity. So far, this trial has recruited 200 participants, and preliminary results indicate that watchful waiting may be a promising strategy. However, more data and longer follow-up of patients are needed to conclude which treatment strategy is the most cost-effective. It is also known that a trial is on-going in the USA but no results are available so far. The methodological quality of the literature reviews was generally poor, and none of the reviews was systematic. Conclusions from nine reviews on anterior crowding suggested that there was only a weak association between retention of third molars and crowding. Six out of 21 reviews with a more general scope also concluded that the prophylactic removal of third molars was unjustified. Twelve general reviews did not conclude with a clear message about the management of third molars. Three reviews suggested that prophylactic removal of third molars is appropriate, but these reviews were of poorer methodological quality than the majority of other reviews. Three out of four papers focusing on surgical management expressed FAU - Song, F AU - Song F AD - NHS Centre for Reviews and Dissemination, University of York, UK. FAU - O'Meara, S AU - O'Meara S FAU - Wilson, P AU - Wilson P FAU - Golder, S AU - Golder S FAU - Kleijnen, J AU - Kleijnen J LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - England TA - Health Technol Assess JT - Health technology assessment (Winchester, England) JID - 9706284 SB - IM MH - Cost-Benefit Analysis MH - Humans MH - Molar, Third/*surgery MH - Postoperative Complications MH - Tooth Extraction/*economics MH - Tooth, Impacted/surgery MH - Tooth, Unerupted/surgery RF - 99 EDAT- 2000/08/10 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/08/10 11:00 PHST- 2000/08/10 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/08/10 11:00 [entrez] PST - ppublish SO - Health Technol Assess. 2000;4(15):1-55. PMID- 25794779 OWN - NLM STAT- MEDLINE DCOM- 20160802 LR - 20150420 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 53 IP - 5 DP - 2015 May TI - Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial. PG - 416-20 LID - S0266-4356(15)00039-X [pii] LID - 10.1016/j.bjoms.2015.02.001 [doi] AB - We investigated the effect of antibiotic prophylaxis on postoperative inflammatory complications after operations for impacted mandibular third molars in Chinese patients. A total of 207 patients had their bilateral third molars removed in a split-mouth, double-blind, self-controlled, clinical trial in two visits. For one side amoxicillin (or clindamycin) was given (antibiotic group) from one hour before operation until 3 days postoperatively. For the other side a placebo was given (placebo group) at the same time. The outcome, including alveolar osteitis, surgical wound infection, prebuccal infection, and infection of the anterior isthmus of fauces, was assessed 2 and 10 days postoperatively. A total of 192 patients completed the study, and there was no difference between the groups in the incidence of inflammatory complications. In the treatment group, there were 4 cases of alveolar osteitis (2%), 2 infections of the wound (1%), and 14 other reactions (gastrointestinal (n=4), bleeding (n=2), ulcer (n=2), and fever (n=6)). In the placebo group, there were 6 cases of alveolar osteitis (3%), 2 wound infections (1%), and 22 other reactions (bleeding (n=6), ulcer (n=2) and fever (n=14)). There was no significant difference in the extraction time and postoperative reactions, except the pain score on day 10 (p=0.005). Prophylactic amoxicillin (or clindamycin) is not effective for the prevention or reduction of postoperative inflammatory complications after the removal of impacted mandibular third molars in Chinese patients. CI - Copyright © 2015. Published by Elsevier Ltd. FAU - Xue, P AU - Xue P AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. FAU - Wang, J AU - Wang J AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. FAU - Wu, B AU - Wu B AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. FAU - Ma, Y AU - Ma Y AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. FAU - Wu, F AU - Wu F AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. FAU - Hou, R AU - Hou R AD - State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. Electronic address: denthr@sina.com. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150318 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anti-Bacterial Agents) RN - 0 (Placebos) RN - 3U02EL437C (Clindamycin) RN - 804826J2HU (Amoxicillin) SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 2015 Oct;53(8):779. PMID: 26048100 MH - Adolescent MH - Adult MH - Amoxicillin/therapeutic use MH - Anti-Bacterial Agents/therapeutic use MH - *Antibiotic Prophylaxis MH - Clindamycin/therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Dry Socket/*prevention & control MH - Female MH - Fever/etiology MH - Humans MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Operative Time MH - Oral Hemorrhage/etiology MH - Oral Ulcer/etiology MH - Osteotomy/methods MH - Pain, Postoperative/etiology MH - Placebos MH - Postoperative Hemorrhage/etiology MH - Surgical Wound Infection/*prevention & control MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - Antibiotic treatment ; OT - Impacted mandibular third molar surgery OT - Inflammatory complications EDAT- 2015/03/22 06:00 MHDA- 2016/08/03 06:00 CRDT- 2015/03/22 06:00 PHST- 2014/07/02 00:00 [received] PHST- 2015/02/01 00:00 [accepted] PHST- 2015/03/22 06:00 [entrez] PHST- 2015/03/22 06:00 [pubmed] PHST- 2016/08/03 06:00 [medline] AID - S0266-4356(15)00039-X [pii] AID - 10.1016/j.bjoms.2015.02.001 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2015 May;53(5):416-20. doi: 10.1016/j.bjoms.2015.02.001. Epub 2015 Mar 18. PMID- 16122590 OWN - NLM STAT- MEDLINE DCOM- 20051004 LR - 20071115 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 63 IP - 9 DP - 2005 Sep TI - The necessity of routine clinic follow-up visits after third molar removal. PG - 1278-82 AB - PURPOSE: This randomized clinical trial was conducted to evaluate the clinical necessity of routine follow-up visits after third molar removal under local anesthesia and intravenous sedation in patients aged 15 to 35 years. PATIENTS AND METHODS: Sixty consecutive cases that required surgical removal of impacted third molars in an outpatient basis were performed by board-certified oral and maxillofacial surgeons. Sixty patients were divided randomly into 2 groups: one group received a 2-week postoperative follow-up appointment and the other received no follow-up. All patients received postoperative instructions and were contacted by telephone on the day after surgery. At 2 weeks postoperatively, all patients either returned to the clinic or were interviewed by telephone. RESULTS: Forty-eight patients were included in this study. The mean age was 20.35 years (range, 15 to 33 years). There were no statistical differences in the number of patients and gender between groups of patients who received clinic or telephone follow-up (significance <.05). Seventy-three percent (35 of 48) of total patients preferred telephone follow-up, and 27% (13 of 48) of patients preferred clinic follow-up. Eighty-five percent (29 of 34) of patients who did not have any complaints on postoperative day 1 preferred telephone follow-up (significance <.01). CONCLUSIONS: A routine follow-up visit following third molar removal under intravenous sedation is not necessary in patients between 15 and 35 years of age. However, preoperative and postoperative instruction should be clearly specified. A selective review policy may be appropriate if a patient is mentally retarded, is taking psychoactive drugs, or has an intraoperative complications or a complaint registered via telephone call. FAU - Sittitavornwong, Somsak AU - Sittitavornwong S AD - Department of Oral and Maxillofacial Surgery, University of Alabama, Birmingham, AL 35294, USA. sjade@uab.edu FAU - Waite, Peter D AU - Waite PD FAU - Holmes, Jon D AU - Holmes JD FAU - Klapow, Joshua C AU - Klapow JC LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Intravenous) SB - AIM SB - D SB - IM CIN - Evid Based Dent. 2006;7(4):92. PMID: 17187035 MH - Adolescent MH - Adult MH - Ambulatory Surgical Procedures MH - Anesthetics, Intravenous/administration & dosage MH - *Appointments and Schedules MH - Conscious Sedation MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology MH - Patient Education as Topic MH - Patient Satisfaction MH - *Postoperative Care MH - Postoperative Complications MH - Telephone MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2005/08/27 09:00 MHDA- 2005/10/05 09:00 CRDT- 2005/08/27 09:00 PHST- 2004/09/13 00:00 [received] PHST- 2005/08/27 09:00 [pubmed] PHST- 2005/10/05 09:00 [medline] PHST- 2005/08/27 09:00 [entrez] AID - S0278-2391(05)00885-2 [pii] AID - 10.1016/j.joms.2005.05.292 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2005 Sep;63(9):1278-82. doi: 10.1016/j.joms.2005.05.292. PMID- 22313644 OWN - NLM STAT- MEDLINE DCOM- 20120621 LR - 20131121 IS - 1681-7168 (Electronic) IS - 1022-386X (Linking) VI - 22 IP - 2 DP - 2012 Feb TI - Efficacy of intra-alveolar chlorhexidine gel in reducing frequency of alveolar osteitis in mandibular third molar surgery. PG - 91-4 AB - OBJECTIVE: To determine the efficacy of intra-alveolar administration of chlorhexidine (CHX) gel in reducing the frequency of alveolar osteitis (AO) after impacted mandibular third molar surgery. STUDY DESIGN: A randomized control trial study. PLACE AND DURATION OF STUDY: Department of Oral and Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi, Pakistan, from January to December 2007. METHODOLOGY: One hundred patients including 65 males and 35 females with the age range 18-40 years were divided in two equal groups (50 each in the CHX and the control groups). Surgical removal of impacted mandibular third molar was carried out and after surgery CHX gel was placed into the alveolus of CHX group. Patients were followed at the first, second and third postoperative days. A proforma indicating presence or absence of pain, blood clot disintegration, halitosis and AO was filled for each patient. Frequencies and percentages were calculated for qualitative data. Chi-square test was applied to compare both subgroups. RESULTS: Eighteen patients (18%) were diagnosed with AO (11 males and 7 females). Out of these 18 cases, 14 (28%) were found in control group (9 males and 5 females), while 4 cases (8%) in the CHX group (2 males and 2 females). This was statistically significant p=0.017. CONCLUSION: Single application of CHX gel was effective in reducing frequency of AO following mandibular third molar surgery. FAU - Babar, Adnan AU - Babar A AD - Department of Oral and Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi, Pakistan. dradnanbabar@yahoo.com FAU - Ibrahim, Muhammad Wasim AU - Ibrahim MW FAU - Baig, Nasir Jamal AU - Baig NJ FAU - Shah, Irfan AU - Shah I FAU - Amin, Erum AU - Amin E LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Pakistan TA - J Coll Physicians Surg Pak JT - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JID - 9606447 RN - 0 (Gels) RN - R4KO0DY52L (Chlorhexidine) SB - IM MH - Administration, Topical MH - Adolescent MH - Adult MH - Chlorhexidine/*administration & dosage MH - Female MH - Follow-Up Studies MH - Gels/administration & dosage MH - Humans MH - Incidence MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Postoperative Care/methods MH - Postoperative Complications/prevention & control MH - Reference Values MH - Tooth Extraction/*adverse effects/methods MH - Tooth Socket/drug effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult EDAT- 2012/02/09 06:00 MHDA- 2012/06/22 06:00 CRDT- 2012/02/09 06:00 PHST- 2010/03/10 00:00 [received] PHST- 2012/01/16 00:00 [accepted] PHST- 2012/02/09 06:00 [entrez] PHST- 2012/02/09 06:00 [pubmed] PHST- 2012/06/22 06:00 [medline] AID - 040579197 [pii] PST - ppublish SO - J Coll Physicians Surg Pak. 2012 Feb;22(2):91-4. PMID- 14663804 OWN - NLM STAT- MEDLINE DCOM- 20040115 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 61 IP - 12 DP - 2003 Dec TI - Hemostatic effect of n-butyl-2-cyanoacrylate (histoacryl) glue in warfarin-treated patients undergoing oral surgery. PG - 1405-9 AB - PURPOSE: Our goal was to evaluate the local hemostatic effect of n-butyl-2-cyanoacrylate (Histoacryl; B. Braun, Melsungen, Germany) glue in warfarin-treated patients who undergo outpatient oral surgery without a change in their level of anticoagulation. MATERIALS AND METHODS: Thirty consecutive warfarin-treated patients randomly assigned to study and control groups and 10 patients who had never been on anticoagulant therapy serving as the negative control group were included in this trial. Before multiple teeth extractions, all patients had a prothrombin time and the international normalized ratio (INR) determined. To gain hemostasis and primary closure, gelatin sponge and multiple interrupted resorbable sutures were used in the control and negative control groups, and Histoacryl glue and the minimal number of interrupted resorbable sutures were used in the study group. Postoperatively, patients were to contact the oral surgeon if abnormal bleeding occurred. Patients who did not have postoperative bleeding were seen on the 10th postoperative day. Data were collected, and statistical differences in age and gender distributions, number of teeth extracted, INR levels, and bleeding that required treatment were analyzed with the Mantel-Haenzel test. Statistical significance was defined as a value of P <.05. RESULTS: Local hemostasis was obtained immediately in study patients and only after 10 to 20 minutes in the control and negative control patients. In relation to bleeding complications, there were no cases of postoperative bleeding requiring treatment in both the negative control patients and study patients. In the control patients, 5 cases had postoperative spontaneous bleeding that required treatment. This difference was statistically significant. No patient had wound infection and the healing process appeared to be normal. CONCLUSION: Multiple extractions can be performed in patients taking oral anticoagulant therapy without a change in their level of anticoagulation provided an efficient local hemostatic measure is instituted. And, in this regard, Histoacryl glue, used as a topical adhesive over approximated wound edges, is an effective and easily applicable local hemostatic for oral surgery in such patients. FAU - Al-Belasy, Fouad A AU - Al-Belasy FA AD - Oral Surgery Department, Faculty of Dentistry, Mansoura University, Egypt. FAU - Amer, Maged Z AU - Amer MZ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anticoagulants) RN - 0 (Fibrin Tissue Adhesive) RN - 0 (Hemostatics) RN - 5Q7ZVV76EI (Warfarin) RN - F8CEP82QNP (Enbucrilate) SB - AIM SB - D SB - IM MH - Aged MH - Ambulatory Surgical Procedures/adverse effects MH - Anticoagulants/*administration & dosage MH - Blood Loss, Surgical/*prevention & control MH - *Dental Care for Chronically Ill MH - Drug Interactions MH - Enbucrilate/*analogs & derivatives/*therapeutic use MH - Female MH - Fibrin Tissue Adhesive/therapeutic use MH - Gelatin Sponge, Absorbable/therapeutic use MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/etiology/*prevention & control MH - Oral Surgical Procedures/adverse effects MH - Polypharmacy MH - Postoperative Hemorrhage/etiology/prevention & control MH - Tooth Extraction/adverse effects MH - Treatment Outcome MH - Warfarin/*administration & dosage EDAT- 2003/12/10 05:00 MHDA- 2004/01/16 05:00 CRDT- 2003/12/10 05:00 PHST- 2003/12/10 05:00 [pubmed] PHST- 2004/01/16 05:00 [medline] PHST- 2003/12/10 05:00 [entrez] AID - S0278239103008395 [pii] AID - 10.1016/j.joms.2002.12.001 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2003 Dec;61(12):1405-9. doi: 10.1016/j.joms.2002.12.001. PMID- 8578511 OWN - NLM STAT- MEDLINE DCOM- 19960314 LR - 20071115 IS - 0340-6245 (Print) IS - 0340-6245 (Linking) VI - 74 IP - 1 DP - 1995 Jul TI - Fibrin sealant in surgery of patients with a hemorrhagic diathesis. PG - 486-92 AB - The utilization of fibrin sealants in patients with hemostatic disorders has hitherto been very limited. Our experiences from 40 major and 8 minor surgical procedures, 10 circumcisions and 118 tooth extractions in 106 patients with hemophilia A, B or von Willebrand's disease, almost exclusively of the severe form, respectively, demonstrate the benefits regarding reduction of blood loss and requirements for systemic replacement therapy. The literature on the use of fibrin sealants in this group of patients, which mainly concerns dental procedures, is reviewed and compared with our data. The importance of the composition of the glue is also discussed in detail. FAU - Martinowitz, U AU - Martinowitz U AD - National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer, Israel. FAU - Schulman, S AU - Schulman S LA - eng PT - Journal Article PT - Review PL - Germany TA - Thromb Haemost JT - Thrombosis and haemostasis JID - 7608063 RN - 0 (Cross-Linking Reagents) RN - 0 (Fibrin Tissue Adhesive) RN - 0 (Hemostatics) RN - 0 (Tissue Adhesives) RN - EC 2.3.2.13 (Transglutaminases) SB - IM MH - Blood Loss, Surgical/*prevention & control MH - Controlled Clinical Trials as Topic MH - Cross-Linking Reagents/metabolism MH - Fibrin Tissue Adhesive/chemistry/economics/*therapeutic use MH - Gingival Hemorrhage/economics/therapy MH - Hemorrhagic Disorders/*drug therapy MH - Hemostatics/chemistry/economics/*therapeutic use MH - Humans MH - Safety MH - Tissue Adhesives/chemistry/economics/*therapeutic use MH - Tooth Extraction/adverse effects/economics MH - Transglutaminases/metabolism RF - 81 EDAT- 1995/07/01 00:00 MHDA- 1995/07/01 00:01 CRDT- 1995/07/01 00:00 PHST- 1995/07/01 00:00 [pubmed] PHST- 1995/07/01 00:01 [medline] PHST- 1995/07/01 00:00 [entrez] PST - ppublish SO - Thromb Haemost. 1995 Jul;74(1):486-92. PMID- 26061574 OWN - NLM STAT- MEDLINE DCOM- 20150806 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 62 IP - 2 DP - 2015 Summer TI - Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials. PG - 57-63 LID - 10.2344/0003-3006-62.2.57 [doi] AB - The purpose of this study was to investigate the effectiveness of preemptive analgesia with nonsteroidal anti-inflammatory drugs (NSAIDs) in third-molar surgery. A PubMed literature search was conducted for articles restricted to the English language using the following terms (DeCS/MeSH) or combinations: analgesia, third molar, and preemptive. From a total of 704 articles, 6 (n=420 subjects) were selected. All studies presented a low risk of bias (Cochrane criteria) but exhibited high heterogeneity of methods. Two studies were excluded from the meta-analysis because they did not have adequate numeric values (dichotomous data) for the calculations. Preemptive analgesia showed no significant benefit (n=298, P=.2227, odds ratio: 2.30, 0.60-8.73) in reducing postoperative pain after removal of lower impacted third molars. However, there was a probable direct relationship between the effectiveness of NSAIDs in preemptive analgesia for removal of third molars and its selectivity for the cyclooxygenase-2 (COX-2). Preemptive analgesia did not have a significant effect in reducing postoperative pain after removal of lower impacted third molars. More homogeneous and well-delineated clinical studies are necessary to determine a possible association between NSAIDs' selectivity for COX-2 and treatment effectiveness. FAU - Costa, Fábio Wildson Gurgel AU - Costa FW AD - Adjunct Professor, Division of Oral Radiology, School of Dentistry, Federal University of Ceará, Brazil. FAU - Esses, Diego Felipe Silveira AU - Esses DF AD - Postgraduate Student, Division of Oral Surgery, Walter Cantídio University Hospital, Fortaleza-CE, Brazil. FAU - de Barros Silva, Paulo Goberlânio AU - de Barros Silva PG AD - Postgraduate Student, Division of Clinical Dentistry, UFC, Fortaleza-CE, Brazil. FAU - Carvalho, Francisco Samuel Rodrigues AU - Carvalho FS AD - Postgraduate Student, Division of Oral Surgery, Walter Cantídio University Hospital, Fortaleza-CE, Brazil. FAU - Sá, Carlos Diego Lopes AU - Sá CD AD - Postgraduate Student, Division of Oral Surgery, Post-program in Dentistry, Federal University of Ceará, Fortaleza-CE, Brazil. FAU - Albuquerque, Assis Filipe Medeiros AU - Albuquerque AF AD - Postgraduate Student, Division of Oral Surgery, Post-program in Dentistry, Federal University of Ceará, Fortaleza-CE, Brazil. FAU - Bezerra, Tácio Pinheiro AU - Bezerra TP AD - Professor, Division of Oral Surgery, Walter Cantídio University Hospital, Fortaleza-CE, Brazil. FAU - Ribeiro, Thyciana Rodrigues AU - Ribeiro TR AD - Adjunct Professor, Division of Special Needs Dental Patients, UFC, Fortaleza-CE, Brazil. FAU - Sá Roriz Fonteles, Cristiane AU - Sá Roriz Fonteles C AD - Associate Professor, Division of Pediatric Dentistry, UFC, Fortaleza-CE, Brazil. FAU - Soares, Eduardo Costa Studart AU - Soares EC AD - Full Professor, Division of Oral Surgery, UFC, Fortaleza-CE, Brazil. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) SB - D MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Humans MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - *Premedication MH - Randomized Controlled Trials as Topic MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery PMC - PMC4462701 OTO - NOTNLM OT - Analgesia OT - Meta-analysis OT - Preemptive OT - Third molar EDAT- 2015/06/11 06:00 MHDA- 2015/08/08 06:00 CRDT- 2015/06/11 06:00 PHST- 2015/06/11 06:00 [entrez] PHST- 2015/06/11 06:00 [pubmed] PHST- 2015/08/08 06:00 [medline] AID - 10.2344/0003-3006-62.2.57 [doi] PST - ppublish SO - Anesth Prog. 2015 Summer;62(2):57-63. doi: 10.2344/0003-3006-62.2.57. PMID- 21757939 OWN - NLM STAT- MEDLINE DCOM- 20111207 LR - 20131121 IS - 1423-0151 (Electronic) IS - 1011-7571 (Linking) VI - 20 IP - 5 DP - 2011 TI - Postoperative analgesia in impacted third molar surgery: the role of preoperative diclofenac sodium, paracetamol and lornoxicam. PG - 470-6 LID - 10.1159/000327658 [doi] AB - OBJECTIVE: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). SUBJECTS AND METHODS: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20). Group P received preoperatively 1 g paracetamol i.v., group D 75 mg diclofenac sodium i.m. and group L 8 mg lornoxicam i.v. Postoperative pain intensity, additional consumption of analgesics postoperatively and postoperative complications were compared among groups. RESULTS: The groups were comparable for pain scores (p > 0.05). Maximum pain scores were recorded in postoperative 4th h in all groups (group L 22, 14-44 mm; group P 24, 13-43 mm; group D 14, 10-24 mm, p = 0.117). Patients experienced high satisfaction scores which were comparable among groups (group L 85, 75-100 mm; group P 87, 70-95 mm; group D 84, 77-98 mm, p = 0.457). CONCLUSION: Preoperative intramuscular diclofenac, intravenous paracetamol and lornoxicam effectively decreased the pain scores. The patients were satisfied with the three postoperative pain management regimens. CI - Copyright © 2011 S. Karger AG, Basel. FAU - Tuzuner Oncul, Aysegul Mine AU - Tuzuner Oncul AM AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey. FAU - Yazicioglu, Duygu AU - Yazicioglu D FAU - Alanoglu, Zekeriyya AU - Alanoglu Z FAU - Demiralp, Samimi AU - Demiralp S FAU - Ozturk, Adnan AU - Ozturk A FAU - Ucok, Cahit AU - Ucok C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20110711 PL - Switzerland TA - Med Princ Pract JT - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JID - 8901334 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 144O8QL0L1 (Diclofenac) RN - 362O9ITL9D (Acetaminophen) RN - ER09126G7A (lornoxicam) SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/*therapeutic use MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/pathology/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Patient Satisfaction MH - Piroxicam/administration & dosage/*analogs & derivatives/therapeutic use MH - Premedication/methods MH - Severity of Illness Index MH - Statistics, Nonparametric MH - Time Factors MH - Tooth, Impacted/*pathology/surgery MH - Young Adult EDAT- 2011/07/16 06:00 MHDA- 2011/12/13 00:00 CRDT- 2011/07/16 06:00 PHST- 2010/06/07 00:00 [received] PHST- 2011/03/03 00:00 [accepted] PHST- 2011/07/16 06:00 [entrez] PHST- 2011/07/16 06:00 [pubmed] PHST- 2011/12/13 00:00 [medline] AID - 000327658 [pii] AID - 10.1159/000327658 [doi] PST - ppublish SO - Med Princ Pract. 2011;20(5):470-6. doi: 10.1159/000327658. Epub 2011 Jul 11. PMID- 8703598 OWN - NLM STAT- MEDLINE DCOM- 19960910 LR - 20190719 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 180 IP - 12 DP - 1996 Jun 22 TI - Lingual nerve damage during lower third molar removal: a comparison of two surgical methods. PG - 456-61 AB - The high incidence of lingual sensory disturbance following lower third molar removal in the UK may be due to the elevation of a lingual flap and insertion of a Howarth's periosteal elevator, in an attempt to protect the lingual nerve. We have therefore studied the validity of this technique by recording the incidence of temporary and permanent lingual nerve injury during 771 operations randomly allocated to be carried out with or without lingual flap retraction. Surgery with lingual flap retraction resulted in lingual sensory disturbance in 6.9% and this persisted, requiring lingual nerve repair, in 0.8%. Surgery without lingual flap retraction resulted in lingual sensory disturbance in 0.8% (P < 0.0001) and this persisted, requiring lingual nerve repair, in 0.3%. We conclude that avoidance of lingual retraction reduces the incidence of temporary lingual nerve disturbance and does not increase the incidence of permanent damage. This indicates that use of the Howarth's in this way is invalid, and suggests that for the majority of cases, lingual retraction should be avoided. FAU - Robinson, P P AU - Robinson PP AD - Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, Claremont Crescent, Sheffield. FAU - Smith, K G AU - Smith KG LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Review PL - England TA - Br Dent J JT - British dental journal JID - 7513219 SB - D SB - IM CIN - Br Dent J. 1996 Aug 24;181(4):121. PMID: 8840574 CIN - Br Dent J. 1996 Aug 24;181(4):121. PMID: 8840575 CIN - Br Dent J. 1996 Aug 24;181(4):122. PMID: 8840576 CIN - Br Dent J. 1996 Aug 24;181(4):122. PMID: 8840577 CIN - Br Dent J. 1996 Sep 7;181(5):163; author reply 164. PMID: 8854417 CIN - Br Dent J. 1996 Sep 7;181(5):164. PMID: 8854418 CIN - Br Dent J. 1996 Sep 7;181(5):164. PMID: 8854419 MH - Humans MH - Incidence MH - Lingual Nerve/surgery MH - *Lingual Nerve Injuries MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Osteotomy/adverse effects/instrumentation MH - Periosteum/surgery MH - Sensation Disorders/etiology/surgery MH - Surgical Flaps MH - Tooth Extraction/*adverse effects RF - 29 EDAT- 1996/06/22 00:00 MHDA- 1996/06/22 00:01 CRDT- 1996/06/22 00:00 PHST- 1996/06/22 00:00 [pubmed] PHST- 1996/06/22 00:01 [medline] PHST- 1996/06/22 00:00 [entrez] AID - 10.1038/sj.bdj.4809126 [doi] PST - ppublish SO - Br Dent J. 1996 Jun 22;180(12):456-61. doi: 10.1038/sj.bdj.4809126. PMID- 25577169 OWN - NLM STAT- MEDLINE DCOM- 20160222 LR - 20170207 IS - 2213-6541 (Electronic) IS - 2213-6533 (Linking) VI - 116 IP - 1 DP - 2015 Feb TI - [Comparison between closure and absence of closure after removal of fully impacted mandibular third molar: a prospective randomized study]. PG - 12-7 LID - S2213-6533(14)00186-4 [pii] LID - 10.1016/j.revsto.2014.11.009 [doi] AB - We prospectively and randomly assessed the absence of surgical wound closure on the patient's postoperative outcome when removing impacted mandibular third molars. MATERIAL AND METHOD: Patients were randomized in 2 groups: the "open group" (O) and the "closed group" (C). We considered the postoperative perimandibular edema, postoperative pain, and limitation of mouth opening at preoperative time, Day2, and Day7. The same physician performed all preoperative (D0) and postoperative measures (D2, D7). RESULTS: Fifty-four patients (27 female and 27 male patients) were included in the study. Ninety-nine cases of impacted mandibular third molars were studied. The statistical analysis revealed a significantly more important postoperative edema in Group C at D2 (P<0.0001) and at D7 (P<0.0001). Postoperative mandibular pain was significantly greater in Group C at D2 (P<0.05) but not at D7 (P>0.05). The decrease of mouth opening was significantly more important in Group C at D2 and at D7 (P<0.05). DISCUSSION: Our prospective randomized study data suggests a significant improvement of postoperative outcome when the mucoperiosteal flap was not sutured after removal of impacted third molars. CI - Copyright © 2014 Elsevier Masson SAS. All rights reserved. FAU - Ricard, A S AU - Ricard AS AD - Service de chirurgie maxillofaciale et stomatologie, centre François-Xavier-Michelet, CHU Pellegrin, place Amélie Raba-Léon, 33076 Bordeaux, France. Electronic address: anne-sophie.ricard@chu-bordeaux.fr. FAU - Nau, O AU - Nau O AD - Service de chirurgie maxillofaciale et stomatologie, centre François-Xavier-Michelet, CHU Pellegrin, place Amélie Raba-Léon, 33076 Bordeaux, France. FAU - Veyret, A AU - Veyret A AD - Service de chirurgie maxillofaciale et stomatologie, centre François-Xavier-Michelet, CHU Pellegrin, place Amélie Raba-Léon, 33076 Bordeaux, France. FAU - Majoufre-Lefèbvre, C AU - Majoufre-Lefèbvre C AD - Service de chirurgie maxillofaciale et stomatologie, centre François-Xavier-Michelet, CHU Pellegrin, place Amélie Raba-Léon, 33076 Bordeaux, France. FAU - Laurentjoye, M AU - Laurentjoye M AD - Service de chirurgie maxillofaciale et stomatologie, centre François-Xavier-Michelet, CHU Pellegrin, place Amélie Raba-Léon, 33076 Bordeaux, France. LA - fre PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Comparaison entre fermeture et absence de fermeture du site d'avulsion des troisièmes molaires mandibulaires incluses: étude prospective randomisée. DEP - 20150107 PL - France TA - Rev Stomatol Chir Maxillofac Chir Orale JT - Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale JID - 101592994 SB - D SB - IM MH - Adolescent MH - Adult MH - Child MH - Edema/epidemiology/etiology MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Postoperative Complications/epidemiology/etiology MH - Sutures MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/epidemiology/*surgery MH - *Wound Closure Techniques/adverse effects MH - Young Adult OTO - NOTNLM OT - Douleur OT - Pain OT - Swelling OT - Third molar OT - Troisième molaire OT - Œdème EDAT- 2015/01/13 06:00 MHDA- 2016/02/24 06:00 CRDT- 2015/01/12 06:00 PHST- 2014/04/28 00:00 [received] PHST- 2014/09/29 00:00 [revised] PHST- 2014/11/20 00:00 [accepted] PHST- 2015/01/12 06:00 [entrez] PHST- 2015/01/13 06:00 [pubmed] PHST- 2016/02/24 06:00 [medline] AID - S2213-6533(14)00186-4 [pii] AID - 10.1016/j.revsto.2014.11.009 [doi] PST - ppublish SO - Rev Stomatol Chir Maxillofac Chir Orale. 2015 Feb;116(1):12-7. doi: 10.1016/j.revsto.2014.11.009. Epub 2015 Jan 7. PMID- 12464207 OWN - NLM STAT- MEDLINE DCOM- 20030409 LR - 20190916 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 40 IP - 6 DP - 2002 Dec TI - Safety and efficacy of levobupivacaine for postoperative pain relief after the surgical removal of impacted third molars: a comparison with lignocaine and adrenaline. PG - 491-6 AB - In a randomised, double-blind placebo-controlled single-centre study we compared the efficacy and safety of 0.75% levobupivacaine (without vasoconstrictor) with 2% lignocaine (with adrenaline 1:80,000) and with placebo for postoperative pain relief in 93 patients having day surgery under general anaesthesia for the removal of impacted mandibular third molars. Premedication and preoperative analgesics were not prescribed, although a short-acting opioid analgesic agent was allowed if required during the anaesthetic procedure. Patients were asked to keep a diary card for 2 days after discharge from hospital. The primary endpoint was the number of patients who requested analgesia within 2 h of completion of the operation. In total, 16 (53%) of patients given levobupivacaine requested analgesia compared with 22 (71%) given lignocaine and 23 (72%) given placebo. Patients given levobupivacaine had lower maximum visual analogue pain scores (VAS) and took longer to request rescue medication (P=0.045 compared with lignocaine). Fewer patients after levobupivacaine n=20 (7%) than after lignocaine n=7 (23%) or placebo n=5 (16%) experienced adverse events. Levobupivacaine seems to be a suitable alternative local anaesthetic to lignocaine with adrenaline for pain control after oral operations. FAU - Rood, J P AU - Rood JP AD - Oral & Maxillofacial Surgery, GKT Dental Institute, King's College Dental Hospital, Caldecot Road, London SE5 9RW, UK. phil.rood@klc.ac.uk FAU - Coulthard, P AU - Coulthard P FAU - Snowdon, A T AU - Snowdon AT FAU - Gennery, B A AU - Gennery BA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - 98PI200987 (Lidocaine) RN - Y8335394RO (Bupivacaine) RN - YKH834O4BH (Epinephrine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthetics, Local/*therapeutic use MH - Bupivacaine/*therapeutic use MH - Double-Blind Method MH - Epinephrine/therapeutic use MH - Facial Pain/drug therapy MH - Female MH - Humans MH - Lidocaine/therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Safety MH - Tooth, Impacted/surgery MH - Vasoconstrictor Agents/therapeutic use EDAT- 2002/12/05 04:00 MHDA- 2003/04/10 05:00 CRDT- 2002/12/05 04:00 PHST- 2002/12/05 04:00 [pubmed] PHST- 2003/04/10 05:00 [medline] PHST- 2002/12/05 04:00 [entrez] AID - S0266435602001845 [pii] AID - 10.1016/s0266-4356(02)00184-5 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2002 Dec;40(6):491-6. doi: 10.1016/s0266-4356(02)00184-5. PMID- 15846686 OWN - NLM STAT- MEDLINE DCOM- 20050719 LR - 20181221 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 2 DP - 2005 Apr 18 TI - Interventions for treating asymptomatic impacted wisdom teeth in adolescents and adults. PG - CD003879 AB - BACKGROUND: The prophylactic removal of asymptomatic impacted wisdom teeth is defined as the (surgical) removal of wisdom teeth in the absence of local disease. Impacted wisdom teeth have been associated with pathological changes, such as inflammation of the gums around the tooth, root resorption, gums- and alveolar bone disease, damage of the adjacent teeth, the development of cysts and tumours. Several other reasons to justify prophylactic removal have also been given. Wisdom teeth do not always fulfil a functional role in the mouth. When surgical removal is carried out in older patients the risk of more postoperative complications, pain and discomfort increases. Nevertheless, in most developed countries the prophylactic removal of trouble-free wisdom teeth, either impacted or fully erupted, has long been considered as 'appropriate care'. Prudent decision-making, with adherence to specified indicators for removal, may reduce the number of surgical procedures by 60% or more. It has been suggested that watchful monitoring of asymptomatic wisdom teeth may be an appropriate strategy. OBJECTIVES: To evaluate the effect of prophylactic removal of asymptomatic impacted wisdom teeth in adolescents and adults compared with the retention of these wisdom teeth. SEARCH STRATEGY: The following electronic databases were searched:The Cochrane Oral Health Group Trials Register (4 August 2004), the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to 4 August 2004), PubMed (1966 to 4 August 2004), EMBASE (1974 to 4 August 2004). There was no restriction on language. Key journals were handsearched. An attempt was made to identify ongoing and unpublished trials. SELECTION CRITERIA: All randomised or controlled clinical trials (RCTs/CCTs) comparing the effect of prophylactic removal of asymptomatic impacted wisdom teeth with no-treatment (retention). DATA COLLECTION AND ANALYSIS: Assessment of relevance, validity and data extraction were conducted in duplicate and independently by three reviewers. Where uncertainty existed, authors were contacted for additional information about randomisation and withdrawals. A quality assessment of the trials was carried out. MAIN RESULTS: Only three trials were identified that satisfied the review selection criteria. Two were completed RCTs and both assessed the influence of prophylactic removal on late incisor crowding in adolescents. One ongoing RCT was identified, but the researchers were unable to provide any data. They intend to publish in the near future and information received will be included in updates. Although both completed trials met the inclusion criteria of the review, regarding participants characteristics, interventions and outcomes assessed, different outcomes measures were assessed which prevented pooling of data. AUTHORS' CONCLUSIONS: No evidence was found to support or refute routine prophylactic removal of asymptomatic impacted wisdom teeth in adults. There is some reliable evidence that suggests that the prophylactic removal of asymptomatic impacted wisdom teeth in adolescents neither reduces nor prevents late incisor crowding. FAU - Mettes, T G AU - Mettes TG AD - Preventive and Curative Dentistry, Radboud University Medical Centre, Philips van Leydenlaan 25, P.O. Box 9101, NL-6500HB, Nijmegen, Netherlands, 6500 HB. d.mettes@dent.umcn.nl FAU - Nienhuijs, M E L AU - Nienhuijs ME FAU - van der Sanden, W J M AU - van der Sanden WJ FAU - Verdonschot, E H AU - Verdonschot EH FAU - Plasschaert, A J M AU - Plasschaert AJ LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20050418 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UIN - Cochrane Database Syst Rev. 2012;6:CD003879. PMID: 22696337 MH - Adolescent MH - Adult MH - Humans MH - Molar, Third/*surgery MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery RF - 30 EDAT- 2005/04/23 09:00 MHDA- 2005/07/20 09:00 CRDT- 2005/04/23 09:00 PHST- 2005/04/23 09:00 [pubmed] PHST- 2005/07/20 09:00 [medline] PHST- 2005/04/23 09:00 [entrez] AID - 10.1002/14651858.CD003879.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2005 Apr 18;(2):CD003879. doi: 10.1002/14651858.CD003879.pub2. PMID- 24535360 OWN - NLM STAT- MEDLINE DCOM- 20150908 LR - 20181202 IS - 1671-167X (Print) IS - 1671-167X (Linking) VI - 46 IP - 1 DP - 2014 Feb 18 TI - [Evaluation of propofol target controlled infusion with fentanyl intravenous sedation on the removal of impacted wisdom tooth]. PG - 107-10 AB - OBJECTIVE: To evaluate the effect and safety of propofol target controlled infusion (TCI) with a small dosage of fentanyl intravenous sedation on the removal of the third impacted molar tooth. METHODS: In the study, 58 ASA (American Society of Anesthesiology) I-II patients with impacted wisdom tooth removal (age: 18-45 years), were divided into two groups: control group (n = 26) received 40 mg lidocaine + propofol TCI; experimental group (n = 32) received 0.8 μg/kg fentanyl + propofol TCI. The complete evaluating indexes were recorded, and the data compared and analyzed. RESULTS: The differences of the gender, age, weight, operation time and sedation time were not significant. The heart rate and bispectral index of the experimental group on local anesthesia injection were significantly lower than those of the control group (P < 0.05). Other differences on heart rate, mean blood pressure, pulse oxygen saturation, respiration rate and bispectral index between the two groups were not significant during operation. The differences on recall of local anesthesia injection, incision and drilling between the two groups were not significant. The pain caused by the propofol injection, and the body movement caused by local anesthesia injection and talkativeness during operation in the experimental group were significantly lower than those in the control group (P < 0.05). No patient in the two groups had nausea and vomiting. After discharge, 19 patients in the experimental group (19/32), 14 patients in the control group (14/26) were sleepy after coming home. The difference of the patient's satisfaction between the two group was not significant, but the patient's satisfaction was significantly higher than the doctor's (P < 0.05), and the doctor's satisfaction in the experimental group was significantly higher than that in the control group (P < 0.05). CONCLUSION: Propofol TCI with a small dosage of fentanyl intravenous sedation on the removal of impacted wisdom tooth is effective and safe. Both patients and doctors have high degree of satisfaction on it. FAU - Guan, Ming AU - Guan M AD - Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China. FAU - Wang, En-bo AU - Wang EB FAU - Liu, Yu AU - Liu Y FAU - Zhang, Wei AU - Zhang W LA - chi PT - Controlled Clinical Trial PT - Journal Article PL - China TA - Beijing Da Xue Xue Bao Yi Xue Ban JT - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences JID - 101125284 RN - 0 (Anesthetics, Intravenous) RN - 98PI200987 (Lidocaine) RN - UF599785JZ (Fentanyl) RN - YI7VU623SF (Propofol) SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/*methods MH - Anesthesia, Intravenous MH - Anesthetics, Intravenous MH - *Fentanyl MH - Heart Rate MH - Humans MH - Lidocaine MH - Middle Aged MH - Molar, Third/*surgery MH - Patient Satisfaction MH - *Propofol MH - *Tooth Extraction MH - Young Adult EDAT- 2014/02/19 06:00 MHDA- 2015/09/09 06:00 CRDT- 2014/02/19 06:00 PHST- 2014/02/19 06:00 [entrez] PHST- 2014/02/19 06:00 [pubmed] PHST- 2015/09/09 06:00 [medline] PST - ppublish SO - Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Feb 18;46(1):107-10. PMID- 15617967 OWN - NLM STAT- MEDLINE DCOM- 20050301 LR - 20201211 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 34 IP - 1 DP - 2005 Jan TI - Primary and secondary closure of the surgical wound after removal of impacted mandibular third molars: a comparative study. PG - 52-7 AB - Primary and secondary closure techniques after removal of impacted third molars were compared in terms of post-operative pain and swelling. Two hundred patients with impacted third molars were randomly divided into two groups of 100. Panoramic radiographs were taken to assess degree of eruption and angulation of third molars. Teeth were extracted, and in Group 1 the socket was closed by hermetically suturing the flap. In Group 2 a 5-6 mm wedge of mucosa adjacent to the second molar was removed to obtain secondary healing. Swelling and pain were evaluated for 7 days after surgery with the VAS scale. The statistical analysis (*analysis of variance for repeated measures, P < 0.05) showed that pain was greater in Group 1, although it decreased over time similarly in the two groups (P = 0.081, F(6,198) = 3.073*). Swelling was significantly worse in Group 1 (P < 0.001, F(6,198) = 44.30*). In Group 1, dehiscence of the mucosa was present in 33% of patients at day 7, and 2% showed signs of re-infection with suppurative alveolitis at 30 days. Pain and swelling were less severe with secondary healing than with primary healing. FAU - Pasqualini, D AU - Pasqualini D AD - Department of Clinical Physiopathology, Dentistry Division, Oral Surgery Unit, University of Turin, Corso Dogliotti 14, Turin 10126, Italy. dampasq@libero.it FAU - Cocero, N AU - Cocero N FAU - Castella, A AU - Castella A FAU - Mela, L AU - Mela L FAU - Bracco, P AU - Bracco P LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adult MH - Analysis of Variance MH - Edema/etiology MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/etiology MH - Prospective Studies MH - Surgical Wound Dehiscence/etiology MH - Suture Techniques/adverse effects MH - Tooth Extraction/*adverse effects/*methods MH - Tooth, Impacted/*surgery EDAT- 2004/12/25 09:00 MHDA- 2005/03/02 09:00 CRDT- 2004/12/25 09:00 PHST- 2004/01/08 00:00 [accepted] PHST- 2004/12/25 09:00 [pubmed] PHST- 2005/03/02 09:00 [medline] PHST- 2004/12/25 09:00 [entrez] AID - S0901502704000505 [pii] AID - 10.1016/j.ijom.2004.01.023 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2005 Jan;34(1):52-7. doi: 10.1016/j.ijom.2004.01.023. PMID- 17694045 OWN - NLM STAT- MEDLINE DCOM- 20071108 LR - 20181201 IS - 1476-5373 (Electronic) IS - 0007-0610 (Linking) VI - 203 IP - 7 DP - 2007 Oct 13 TI - Evaluation of dental extractions, suturing and INR on postoperative bleeding of patients maintained on oral anticoagulant therapy. PG - E15; discussion 410-1 AB - OBJECTIVES: To examine the consequences of temporary withdrawal of warfarin and/or suturing on bleeding and healing pattern following dental extractions. METHODS: Two hundred and fourteen patients on long-term oral anticoagulation (warfarin) therapy scheduled for dental extraction were randomly divided into four groups: no suturing and discontinued (group 1) or continued warfarin (group 2), and suturing and discontinued (group 3) or continued warfarin (group 4). International normalised ratio (INR) was determined at different time points (baseline, days 1, 3 and 7). RESULTS: Discontinuing warfarin reduced INR level significantly at day 1, which subsequently reached <1.5 in 96 out of 104 patients (group 1 and 3). Statistical comparisons among the different treatment groups did not reveal any significant difference regarding bleeding status or healing pattern. Interestingly, patients who received sutures showed higher but insignificant incidence of bleeding postoperatively compared to their respective controls. CONCLUSION: Dental extractions may be safely performed for patients on anticoagulation therapy provided the INR level is kept <3.0 and effective measures of local haemostasis are administered. The decision to suture should be made on case-by-case basis, as the trauma associated with soft tissue handling might outweigh its advantages in certain situations like simple extractions. FAU - Al-Mubarak, S AU - Al-Mubarak S AD - Dental Department, Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi Arabia. smubarak@humanitariancity.org.sa FAU - Al-Ali, N AU - Al-Ali N FAU - Abou-Rass, M AU - Abou-Rass M FAU - Al-Sohail, A AU - Al-Sohail A FAU - Robert, A AU - Robert A FAU - Al-Zoman, K AU - Al-Zoman K FAU - Al-Suwyed, A AU - Al-Suwyed A FAU - Ciancio, S AU - Ciancio S LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20070810 PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM CIN - Evid Based Dent. 2008;9(1):7. PMID: 18364682 MH - Anticoagulants/administration & dosage/*adverse effects MH - Female MH - Humans MH - International Normalized Ratio/*standards MH - Male MH - Middle Aged MH - Postoperative Hemorrhage/*chemically induced MH - Statistics, Nonparametric MH - Suture Techniques/*statistics & numerical data MH - Tooth Extraction/adverse effects/*methods MH - Warfarin/administration & dosage/*adverse effects EDAT- 2007/08/19 09:00 MHDA- 2007/11/09 09:00 CRDT- 2007/08/19 09:00 PHST- 2007/03/05 00:00 [accepted] PHST- 2007/08/19 09:00 [pubmed] PHST- 2007/11/09 09:00 [medline] PHST- 2007/08/19 09:00 [entrez] AID - bdj.2007.725 [pii] AID - 10.1038/bdj.2007.725 [doi] PST - ppublish SO - Br Dent J. 2007 Oct 13;203(7):E15; discussion 410-1. doi: 10.1038/bdj.2007.725. Epub 2007 Aug 10. PMID- 24813776 OWN - NLM STAT- MEDLINE DCOM- 20140815 LR - 20140929 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 72 IP - 7 DP - 2014 Jul TI - Outcome following lingual nerve repair with vein graft cuff: a preliminary report. PG - 1433.e1-7 LID - S0278-2391(14)00331-0 [pii] LID - 10.1016/j.joms.2014.03.018 [doi] AB - PURPOSE: The object of this study was to assess the effects of an inside-out vein graft as a cuff after direct suture on human lingual nerve regeneration and recovery after iatrogenic lingual nerve injury. PATIENTS AND METHODS: Ten patients with unilateral lingual nerve anesthesia as a complication of iatrogenic injury after third molar extraction underwent microneurosurgical procedures for the injured lingual nerve under general anesthesia. The patients were randomized into 2 groups. In group A, after removing the neuromas and peripheral scars surrounding the torn nerves, the 2 nerve ends were sutured without tension. In group B, after the same procedure, including the same suturing procedure, an inside-out vein graft was placed as a cuff after the direct suture. Each group was followed at least once every 6 months for 1 year after the procedure. Postoperative outcomes were evaluated using the Pogrel criteria, the Sunderland grade, and the British Medical Research Council Scale (MRCS). RESULTS: There were no particular differences between groups A and B at 6 and 12 months after the operation. However, based on the MRCS criteria, there was a clearly better result in group B than in group A at 6 and 12 months after the operation, and the recovery of gustatory sensation tended to be better in group B than in group A 1 year after the operation. CONCLUSION: This inside-out vein graft as a cuff after direct suturing may facilitate faster lingual nerve regeneration than the traditional direct suture approach. The inside-out vein graft as a cuff may provide the advantages of preventing axonal escape at the suture lines, minimizing nerve entrapment, and preventing neuroma formation in the space between the sutured nerves. CI - Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Fujita, Shigeyuki AU - Fujita S AD - Professor, Department of Oral and Maxillofacial Surgery Wakayama Medical University, Wakayama City, Japan. Electronic address: fujt@wakayama-med.ac.jp. FAU - Tojyo, Itaru AU - Tojyo I AD - Associate Professor, Department of Oral and Maxillofacial Surgery Wakayama Medical University, Wakayama City, Japan. FAU - Yamada, Masai AU - Yamada M AD - Research Fellow, Department of Oral and Maxillofacial Surgery Wakayama Medical University, Wakayama City, Japan. FAU - Go, Yoshihiko AU - Go Y AD - Research Fellow, Department of Oral and Maxillofacial Surgery Wakayama Medical University, Wakayama City, Japan. FAU - Matsumoto, Takashi AU - Matsumoto T AD - Research Fellow, Department of Oral and Maxillofacial Surgery Wakayama Medical University, Wakayama City, Japan. FAU - Kiga, Norifumi AU - Kiga N AD - Assistant Professor, Department of Oral and Maxillofacial Surgery Wakayama Medical University, Wakayama City, Japan. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20140401 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Lingual Nerve/*surgery MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Tooth Extraction/adverse effects MH - Treatment Outcome MH - Veins/*transplantation MH - Young Adult EDAT- 2014/05/13 06:00 MHDA- 2014/08/16 06:00 CRDT- 2014/05/13 06:00 PHST- 2013/11/11 00:00 [received] PHST- 2014/03/17 00:00 [revised] PHST- 2014/03/19 00:00 [accepted] PHST- 2014/05/13 06:00 [entrez] PHST- 2014/05/13 06:00 [pubmed] PHST- 2014/08/16 06:00 [medline] AID - S0278-2391(14)00331-0 [pii] AID - 10.1016/j.joms.2014.03.018 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2014 Jul;72(7):1433.e1-7. doi: 10.1016/j.joms.2014.03.018. Epub 2014 Apr 1. PMID- 21403575 OWN - NLM STAT- MEDLINE DCOM- 20110923 LR - 20131121 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 22 IP - 2 DP - 2011 Mar TI - Antibiotic prophylaxis in third molar surgery. PG - 551-3 LID - 10.1097/SCS.0b013e31820745c7 [doi] AB - AIMS AND OBJECTIVES: To evaluate the role of prophylactic antibiotics, if any, in the removal of mandibular impacted third molars. PATIENTS AND METHODS: A total of 89 patients were randomly allocated in 3 groups (group 1, placebo; group 2, amoxicillin 1 g orally 1 h before surgery; and group 3, metronidazole 800 mg orally 1 h before surgery). RESULTS: Of the 89 patients, 5 had surgical wound infection (3 [10.33%] in group 1, 2 [6.45%] in group 2, and none [0%] in group 3), leading to an overall infection rate of 5.61%. There was no statistically significant difference found in surgical wound infection between the groups. CONCLUSIONS: Our study failed to show any advantage in the routine use of prophylactic antibiotics because we found no statistically significant difference between the groups. FAU - Pasupathy, Sanjay AU - Pasupathy S AD - Department of Oral and Maxillofacial Surgery, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Pondicherry, Union Territory, India. FAU - Alexander, Mohan AU - Alexander M LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 140QMO216E (Metronidazole) RN - 804826J2HU (Amoxicillin) SB - D MH - Adolescent MH - Adult MH - Amoxicillin/administration & dosage MH - Analysis of Variance MH - *Antibiotic Prophylaxis MH - Chi-Square Distribution MH - Humans MH - Male MH - Metronidazole/administration & dosage MH - Middle Aged MH - Molar, Third/*surgery MH - Surgical Wound Infection/*prevention & control MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2011/03/16 06:00 MHDA- 2011/09/29 06:00 CRDT- 2011/03/16 06:00 PHST- 2011/03/16 06:00 [entrez] PHST- 2011/03/16 06:00 [pubmed] PHST- 2011/09/29 06:00 [medline] AID - 10.1097/SCS.0b013e31820745c7 [doi] PST - ppublish SO - J Craniofac Surg. 2011 Mar;22(2):551-3. doi: 10.1097/SCS.0b013e31820745c7. PMID- 23541425 OWN - NLM STAT- MEDLINE DCOM- 20140108 LR - 20130521 IS - 1872-6623 (Electronic) IS - 0304-3959 (Linking) VI - 154 IP - 6 DP - 2013 Jun TI - TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction. PG - 808-12 LID - S0304-3959(13)00046-8 [pii] LID - 10.1016/j.pain.2013.02.004 [doi] AB - The effects of a TRPV1 antagonist (AZD1386) were investigated in patients with acute pain. After removal of a mandibular third molar and at request of analgesia 103 patients randomly received 95 mg AZD1386 (n = 40), placebo (n = 40) or 500 mg naproxen (n = 23) in a double-blind manner. Plasma samples were drawn, and pain intensity and body temperature were measured during 8 h after drug administration. The pain intensity difference from drug intake was calculated as a percentage (PID%) and as a weighted sum over the 8 h (SPID%0-8 h). The time to first perceptible and first meaningful pain relief was recorded. SPID%(0-8) h showed no significant difference between AZD1386 and placebo (P = .132) but between naproxen and placebo (P = .038). AZD1386 had a rapid short-lasting analgesia and compared to placebo, PID% was significantly higher (P ≤ .026) at 0.25, 0.50, 0.75 and 1.00 h after drug administration. Correspondingly, for naproxen significantly higher PID% (P ≤ .021) was seen at 2.5, 3, 4, 5, 6, 7 and 8 h. The frequency of patients obtaining perceptible and meaningful pain relief was about 85% and 48% after AZD1386 and about 53% and 25% after placebo. The occurrence of perceptible and meaningful pain relief was significantly faster (P = .002 and P = .031) for AZD1386 compared to placebo. Adverse events were similar to placebo with the exception of 2 patients reporting chills. The highest individual body temperature after AZD1386 was 38.1°C, recorded in 2 patients. In summary, AZD1386 was well tolerated with a rapid analgesia that was short lasting despite sustained plasma concentration. CI - Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. FAU - Quiding, Hans AU - Quiding H AD - AstraZeneca R&D, Södertälje, Sweden. hans.quiding@ymail.com FAU - Jonzon, Bror AU - Jonzon B FAU - Svensson, Ola AU - Svensson O FAU - Webster, Lynn AU - Webster L FAU - Reimfelt, Annika AU - Reimfelt A FAU - Karin, Aleksandra AU - Karin A FAU - Karlsten, Rolf AU - Karlsten R FAU - Segerdahl, Märta AU - Segerdahl M LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20130219 PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (AZD1386) RN - 0 (Analgesics) RN - 0 (Benzimidazoles) RN - 0 (TRPV Cation Channels) RN - 0 (TRPV1 protein, human) RN - 57Y76R9ATQ (Naproxen) SB - IM MH - Adolescent MH - Adult MH - Analgesics/*therapeutic use MH - Benzimidazoles/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Naproxen/therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - TRPV Cation Channels/*antagonists & inhibitors MH - Tooth Extraction/*adverse effects MH - Treatment Outcome EDAT- 2013/04/02 06:00 MHDA- 2014/01/09 06:00 CRDT- 2013/04/02 06:00 PHST- 2013/01/09 00:00 [received] PHST- 2013/02/05 00:00 [accepted] PHST- 2013/04/02 06:00 [entrez] PHST- 2013/04/02 06:00 [pubmed] PHST- 2014/01/09 06:00 [medline] AID - S0304-3959(13)00046-8 [pii] AID - 10.1016/j.pain.2013.02.004 [doi] PST - ppublish SO - Pain. 2013 Jun;154(6):808-12. doi: 10.1016/j.pain.2013.02.004. Epub 2013 Feb 19. PMID- 3926667 OWN - NLM STAT- MEDLINE DCOM- 19850925 LR - 20191030 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 14 IP - 3 DP - 1985 Jun TI - Decadronphosphate in the relief of complaints after third molar surgery. A double-blind, controlled trial with bilateral oral surgery. PG - 235-40 AB - The purpose of the present double-blind study was to investigate the preventive effect of 4 mg dexamethasone (1 ml Decadronphosphate) on swelling, trismus and pain after removal of impacted mandibular third molars. The population comprised 30 healthy individuals (17 female, 13 male) who needed removal of 2 identical, impacted mandibular third molars. Each patient served as his own control as the teeth were removed in 2 sittings with either steroid or placebo injected into the masseter muscle just before starting the operation. Control visits took place 48 h and 7 days after the operations. The results showed that steroid administration led to about 50% reduction of postoperative swelling and trismus and to about 30% reduction of postoperative pain. No general or local complaints/complications occurred due to the steroid injection. It is concluded that prophylactic steroid treatment is effective in reducing postoperative complaints and that the administration is safe in the absence of contraindications for such administration. Prophylactic steroid treatment is therefore recommended in third molar surgery when pronounced postoperative reaction can be expected. FAU - Pedersen, A AU - Pedersen A LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 2BP70L44PR (dexamethasone 21-phosphate) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adolescent MH - Adult MH - Dexamethasone/administration & dosage/*analogs & derivatives/therapeutic use MH - Double-Blind Method MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Molar, Third/*surgery MH - Mouth Diseases/etiology/prevention & control MH - Pain, Postoperative/etiology/prevention & control MH - Premedication MH - Tooth Extraction/*adverse effects MH - Trismus/etiology/prevention & control EDAT- 1985/06/01 00:00 MHDA- 1985/06/01 00:01 CRDT- 1985/06/01 00:00 PHST- 1985/06/01 00:00 [pubmed] PHST- 1985/06/01 00:01 [medline] PHST- 1985/06/01 00:00 [entrez] AID - 10.1016/s0300-9785(85)80034-x [doi] PST - ppublish SO - Int J Oral Surg. 1985 Jun;14(3):235-40. doi: 10.1016/s0300-9785(85)80034-x. PMID- 11128259 OWN - NLM STAT- MEDLINE DCOM- 20010111 LR - 20191210 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 189 IP - 10 DP - 2000 Nov 25 TI - A controlled trial of three referral methods for patients with third molars. PG - 556-60 AB - AIM: To evaluate the accuracy, sensitivity and specificity of three primary to secondary care referral strategies. METHOD: Thirty two primary care dental practitioners (GDPs) were randomly allocated one of three referral strategies: current practice (control strategy); a neural network embedded within a computer program and a paper-based clinical algorithm. One hundred and seven patients were assessed for lower third molar treatment: 47, 30 and 30 in each group, respectively. Clinical details were assessed by a panel of experts against a gold standard for third molar removal (the National Institutes of Health criteria). The accuracy, sensitivity, specificity, positive and negative predictive values were calculated for each strategy. RESULTS: The referral decisions made by the GDPs in the control group displayed greater accuracy and sensitivity but poorer specificity (0.83; 0.97; 0.22) compared with the neural network (0.67; 0.56; 0.79) and clinical algorithm (0.73; 0.56; 0.93). CONCLUSIONS: It was concluded that incorporation of the clinical algorithm into primary care was the most appropriate option. The computer neural network performed less well than either current practice or the clinical algorithm. FAU - Goodey, R D AU - Goodey RD AD - Department of Oral Surgery, Medicine and Pathology, University of Wales College of Medicine, Dental School, Cardiff. FAU - Brickley, M R AU - Brickley MR FAU - Hill, C M AU - Hill CM FAU - Shepherd, J P AU - Shepherd JP LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br Dent J JT - British dental journal JID - 7513219 SB - D SB - IM MH - Adolescent MH - Adult MH - Algorithms MH - Chi-Square Distribution MH - Decision Making MH - *Decision Support Techniques MH - Dental Service, Hospital/statistics & numerical data MH - Female MH - General Practice, Dental/*methods MH - Humans MH - Male MH - Mandible MH - Middle Aged MH - Molar, Third/*surgery MH - Neural Networks, Computer MH - *Referral and Consultation/statistics & numerical data MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Statistics, Nonparametric MH - Surgery, Oral/statistics & numerical data MH - *Tooth Extraction EDAT- 2000/12/29 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/12/29 11:00 PHST- 2000/12/29 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/12/29 11:00 [entrez] AID - 10.1038/sj.bdj.4800828 [doi] PST - ppublish SO - Br Dent J. 2000 Nov 25;189(10):556-60. doi: 10.1038/sj.bdj.4800828. PMID- 3057146 OWN - NLM STAT- MEDLINE DCOM- 19890112 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 46 IP - 12 DP - 1988 Dec TI - Comparison of the use of nalbuphine and fentanyl during third molar surgery. PG - 1048-50 AB - In a double-blind, randomized plan of drug administration, nalbuphine, fentanyl, and a placebo were compared for efficacy in sedation and analgesia during third molar removal. Fifty-eight patients participated in this study. Using accepted intravenous sedation and surgical techniques, fentanyl and nalbuphine were found to be better than placebo for anxiety and pain control in third molar surgery. Fentanyl had a longer duration of pain relief postoperatively than did nalbuphine. The study confirmed the need for a narcotic supplement to sedation techniques for third molar surgery. FAU - Canning, H B AU - Canning HB AD - Keesler Medical Center, Biloxi, Mississippi. FAU - Frost, D E AU - Frost DE FAU - McDonald, D K AU - McDonald DK FAU - Joyner, R W AU - Joyner RW LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics) RN - 0 (Morphinans) RN - 0 (Placebos) RN - L2T84IQI2K (Nalbuphine) RN - Q3JTX2Q7TU (Diazepam) RN - UF599785JZ (Fentanyl) SB - AIM SB - D SB - IM MH - *Analgesics MH - Clinical Trials as Topic MH - Diazepam MH - Double-Blind Method MH - Fentanyl/*therapeutic use MH - Humans MH - Male MH - Molar, Third/*surgery MH - Morphinans/*therapeutic use MH - Nalbuphine/*therapeutic use MH - Patient Compliance MH - Placebos MH - Preanesthetic Medication MH - Random Allocation MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1988/12/01 00:00 MHDA- 1988/12/01 00:01 CRDT- 1988/12/01 00:00 PHST- 1988/12/01 00:00 [pubmed] PHST- 1988/12/01 00:01 [medline] PHST- 1988/12/01 00:00 [entrez] AID - 0278-2391(88)90449-1 [pii] AID - 10.1016/0278-2391(88)90449-1 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1988 Dec;46(12):1048-50. doi: 10.1016/0278-2391(88)90449-1. PMID- 24332587 OWN - NLM STAT- MEDLINE DCOM- 20141218 LR - 20140402 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 43 IP - 5 DP - 2014 May TI - Effect of the route of administration of methylprednisolone on oedema and trismus in impacted lower third molar surgery. PG - 639-43 LID - S0901-5027(13)01169-7 [pii] LID - 10.1016/j.ijom.2013.11.005 [doi] AB - Due to their anatomical position, the surgical removal of impacted third molars results in oedema, pain, and trismus. The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation. This randomized, prospective, and controlled study included 44 patients. The patients were randomly divided into four groups: group 1 (control; no steroids), group 2 (local injection), group 3 (oral tablets), and group 4 (i.v. injection). On days 2 and 7 following surgery, linear oedema was determined using facial landmarks, and maximal mouth opening was measured. Postoperative mouth opening and swelling were evaluated for each route of methylprednisolone administration and compared. The female (59%) to male (41%) ratio was 1.44; the mean age of the patients was 29.6 years. The level of significance was set at P<0.01 for mouth opening and P<0.05 for oedema. With regard to trismus, all three routes of administration demonstrated better efficacy in comparison to the control. While oral administration and i.v. injection of methylprednisolone achieved similar results, masseter injection provided better results in reducing oedema and trismus when compared to the control following lower third molar surgery. CI - Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Koçer, G AU - Koçer G AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Süleyman Demirel, Isparta, Turkey. Electronic address: gulperikocer@yahoo.com. FAU - Yuce, E AU - Yuce E AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Süleyman Demirel, Isparta, Turkey. FAU - Tuzuner Oncul, A AU - Tuzuner Oncul A AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Ankara, Ankara, Turkey. FAU - Dereci, O AU - Dereci O AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Osman Gazi, Eskişehir, Turkey. FAU - Koskan, O AU - Koskan O AD - Department of Biometry, Faculty of Agriculture, University of Süleyman Demirel, Isparta, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20131212 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*administration & dosage MH - Drug Administration Routes MH - Edema/etiology/*prevention & control MH - Female MH - Humans MH - Male MH - Methylprednisolone/*administration & dosage MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/etiology/*prevention & control OTO - NOTNLM OT - methylprednisolone OT - third molar surgery EDAT- 2013/12/18 06:00 MHDA- 2014/12/19 06:00 CRDT- 2013/12/17 06:00 PHST- 2013/04/04 00:00 [received] PHST- 2013/08/23 00:00 [revised] PHST- 2013/11/01 00:00 [accepted] PHST- 2013/12/17 06:00 [entrez] PHST- 2013/12/18 06:00 [pubmed] PHST- 2014/12/19 06:00 [medline] AID - S0901-5027(13)01169-7 [pii] AID - 10.1016/j.ijom.2013.11.005 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2014 May;43(5):639-43. doi: 10.1016/j.ijom.2013.11.005. Epub 2013 Dec 12. PMID- 17236918 OWN - NLM STAT- MEDLINE DCOM- 20070308 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 65 IP - 2 DP - 2007 Feb TI - Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery? PG - 177-85 AB - PURPOSE: To estimate and compare the frequencies of inflammatory complications after third molar (M3) surgery in subjects receiving intravenous prophylactic antibiotics or saline placebo. MATERIALS AND METHODS: Using a placebo-controlled, double-blind, randomized clinical trial, the investigators enrolled a sample composed of subjects who required extraction of at least 1 impacted M3 and requested intravenous sedation or general anesthesia. The predictor variable was treatment group classified as active treatment (penicillin or clindamycin for penicillin-allergic subjects) or placebo (0.9% saline). Study medications were randomly assigned. Both surgeon and subject were blinded to treatment assignment. The medication was administered intravenously prior to any incision. The outcome variable was postoperative inflammatory complication classified as present or absent and included alveolar osteitis (AO) or surgical site infection (SSI). Other variables were demographic, anatomic, or operative. Descriptive and bivariate statistics were computed. Statistical significance was set at P < or = .05, single-tailed test of hypothesis. RESULTS: The sample was composed of 118 subjects (n = 59 per study group). In the active treatment group, there were no postoperative inflammatory complications. In the placebo group, 5 subjects (8.5%) were diagnosed with SSI, (P = .03). No subject met the case definition for AO. All SSIs were associated with the removal of partial bony or full bony impacted mandibular M3s. CONCLUSION: In the setting of third molar removal, these results suggest that the use of intravenous antibiotics administered prophylactically decrease the frequency of SSIs. The authors cannot comment on the efficacy of intravenous antibiotics in comparison to other antibacterial treatment regimens, eg chlorhexidine mouthrinse or intrasocket antibiotics. FAU - Halpern, Leslie R AU - Halpern LR AD - Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA 02114, USA. lhalpern1@partners.org FAU - Dodson, Thomas B AU - Dodson TB LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Bacterial Agents) RN - 0 (Penicillins) RN - 3U02EL437C (Clindamycin) SB - AIM SB - D SB - IM CIN - J Evid Based Dent Pract. 2008 Mar;8(1):26-7. PMID: 18346700 MH - Adult MH - Analysis of Variance MH - Anti-Bacterial Agents/administration & dosage MH - *Antibiotic Prophylaxis MH - Clindamycin/administration & dosage MH - Double-Blind Method MH - Dry Socket/etiology/*prevention & control MH - Female MH - Humans MH - Injections, Intravenous MH - Male MH - Molar, Third/*surgery MH - Penicillins/administration & dosage MH - Surgical Wound Infection/etiology/*prevention & control MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 2007/01/24 09:00 MHDA- 2007/03/09 09:00 CRDT- 2007/01/24 09:00 PHST- 2006/04/14 00:00 [received] PHST- 2006/06/27 00:00 [revised] PHST- 2006/10/05 00:00 [accepted] PHST- 2007/01/24 09:00 [pubmed] PHST- 2007/03/09 09:00 [medline] PHST- 2007/01/24 09:00 [entrez] AID - S0278-2391(06)01908-2 [pii] AID - 10.1016/j.joms.2006.10.016 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2007 Feb;65(2):177-85. doi: 10.1016/j.joms.2006.10.016. PMID- 20346565 OWN - NLM STAT- MEDLINE DCOM- 20100611 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 68 IP - 6 DP - 2010 Jun TI - Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. PG - 1322-6 LID - 10.1016/j.joms.2009.08.022 [doi] AB - PURPOSE: Chlorhexidine (CHX) is an antimicrobial agent used in the prevention of tooth decay, periodontal disease, and postextraction alveolar osteitis (AO). Recently, a bioadhesive gel to deliver the active substance, CHX, was introduced. The intra-alveolar placement of the bioadhesive gel allows a more direct and prolonged therapeutic effect of CHX, which is useful in the prevention of AO after extraction of impacted third molars. The intra-alveolar application of the bioadhesive CHX gel in patients with bleeding disorders may increase the risk of postoperative bleeding complications. Inversely, bleeding disorders might influence the efficacy of CHX for AO prevention. The purpose of the present study was to evaluate the effectiveness of the bioadhesive 0.2% CHX gel in reducing the incidence of impacted third molar postextraction AO in patients with bleeding disorders. MATERIALS AND METHODS: We performed a double-blind, randomized, parallel-group study of 38 patients with bleeding disorders. The experimental group (n = 14) was treated with bioadhesive 0.2% CHX gel applied intraoperatively once after surgical removal of the third molar. The control group (n = 24) was treated in an identical fashion with placebo gel. RESULTS: We observed a 57.15% reduction in the incidence of AO in the experimental group. The control group had a 17% incidence of AO and the experimental group had a 7% incidence of AO (P = .402). Bleeding complications occurred in 21% of the experimental group compared with 29% of the control group (P = .601). CONCLUSIONS: As described in previous studies, the single intra-alveolar application of the bioadhesive 0.2% CHX gel in an intraoperative fashion seems to reduce the incidence of AO after removal of impacted third molars in patients with bleeding disorders. On the basis of the reported percentage of bleeding complications, the routine use of postoperative local hemostatic measures is recommended. CI - 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Torres-Lagares, Daniel AU - Torres-Lagares D AD - Oral Surgery Department, University of Seville, Seville, Spain. FAU - Gutierrez-Perez, Jose Luis AU - Gutierrez-Perez JL FAU - Hita-Iglesias, Pilar AU - Hita-Iglesias P FAU - Magallanes-Abad, Natale AU - Magallanes-Abad N FAU - Flores-Ruiz, Rafael AU - Flores-Ruiz R FAU - Basallote-Garcia, Marta AU - Basallote-Garcia M FAU - Gonzalez-Martin, Maribel AU - Gonzalez-Martin M LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20100325 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Gels) RN - 0 (Hemostatics) RN - R4KO0DY52L (Chlorhexidine) SB - AIM SB - D SB - IM MH - Administration, Topical MH - Adolescent MH - Adult MH - Alveolar Process/surgery MH - Anti-Infective Agents, Local/*administration & dosage MH - Chi-Square Distribution MH - Chlorhexidine/*administration & dosage MH - Dental Care for Chronically Ill/*methods MH - Double-Blind Method MH - Dry Socket/etiology/*prevention & control MH - Female MH - Gels MH - *Hemorrhagic Disorders MH - Hemostatics/administration & dosage MH - Humans MH - Intraoperative Care MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Postoperative Care MH - Postoperative Hemorrhage/etiology/*prevention & control MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Young Adult EDAT- 2010/03/30 06:00 MHDA- 2010/06/12 06:00 CRDT- 2010/03/30 06:00 PHST- 2009/06/05 00:00 [received] PHST- 2009/08/25 00:00 [accepted] PHST- 2010/03/30 06:00 [entrez] PHST- 2010/03/30 06:00 [pubmed] PHST- 2010/06/12 06:00 [medline] AID - S0278-2391(09)01627-9 [pii] AID - 10.1016/j.joms.2009.08.022 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2010 Jun;68(6):1322-6. doi: 10.1016/j.joms.2009.08.022. Epub 2010 Mar 25. PMID- 15544888 OWN - NLM STAT- MEDLINE DCOM- 20050119 LR - 20131121 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 42 IP - 6 DP - 2004 Dec TI - Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial. PG - 555-8 AB - We randomised 119 patients who had been referred for removal of partially impacted mandibular third molars to be given either metronidazole 1600 mg or placebo as a single dose 45 min before operation. Ten of the fifty-nine patients who were given metronidazole and 13 of the 60 given placebo developed dry sockets. Two variables were significantly associated with the development of a dry socket: pericoronitis and oral contraceptives. FAU - Bergdahl, M AU - Bergdahl M AD - Department of Odontology, Faculty of Medicine and Odontology, Umeå University, Umeå, Sweden. FAU - Hedström, L AU - Hedström L LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anti-Infective Agents) RN - 0 (Contraceptives, Oral) RN - 140QMO216E (Metronidazole) SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Anti-Infective Agents/*administration & dosage MH - Chi-Square Distribution MH - Contraceptives, Oral/adverse effects MH - Double-Blind Method MH - Dry Socket/etiology/*prevention & control MH - Female MH - Humans MH - Logistic Models MH - Male MH - Mandible MH - Metronidazole/*administration & dosage MH - Molar, Third/*surgery MH - Pericoronitis/complications MH - Preoperative Care MH - Statistics, Nonparametric MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/complications/*surgery EDAT- 2004/11/17 09:00 MHDA- 2005/01/20 09:00 CRDT- 2004/11/17 09:00 PHST- 2004/06/15 00:00 [accepted] PHST- 2004/11/17 09:00 [pubmed] PHST- 2005/01/20 09:00 [medline] PHST- 2004/11/17 09:00 [entrez] AID - S0266-4356(04)00136-6 [pii] AID - 10.1016/j.bjoms.2004.06.015 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2004 Dec;42(6):555-8. doi: 10.1016/j.bjoms.2004.06.015. PMID- 22327817 OWN - NLM STAT- MEDLINE DCOM- 20130708 LR - 20130722 IS - 1938-2723 (Electronic) IS - 1076-0296 (Linking) VI - 19 IP - 1 DP - 2013 Jan-Feb TI - Evaluation of the hemostatic effects of Ankaferd blood stopper during dental extractions in patients on antithrombotic therapy. PG - 96-9 LID - 10.1177/1076029611435836 [doi] AB - This study evaluated the early hemostatic effects of a novel hemostatic agent (Ankaferd blood stopper [ABS]) during dental extractions in patients on antithrombotic therapy, without interruption or diminution of the medication. In total, 25 patients, who are on antithrombotic therapy and in need of simple dental extractions, were randomized into 2 groups. In group I (control group), which consisted of 10 patients, local hemostasis was achieved with direct packing with gauze. In group II, which consisted of 15 patients, local hemostasis was achieved by the local application of ABS on the extraction sockets. The bleeding time was compared between 2 groups following the tooth extraction. The bleeding time in the dental sockets treated with ABS was statistically lower compared to the sockets of the control group (p = 0.0001). It is concluded that the dental extractions could be performed without interruption of the medication in patients on antithrombotic therapy. The ABS appears to be sufficient as an alternative hemostatic agent. FAU - Çakarer, Sirmahan AU - Çakarer S AD - Department of Oral and Maxillofacial Surgery, Istanbul University, Dentistry Faculty, Istanbul, Turkey. sirmacakar@yahoo.com FAU - Eyüpoğlu, Esra AU - Eyüpoğlu E FAU - Günes, Çiğdem Özçamur AU - Günes ÇÖ FAU - Küseoğlu, Banu Gürkan AU - Küseoğlu BG FAU - Berberoğlu, Hülya Koçak AU - Berberoğlu HK FAU - Keskin, Cengizhan AU - Keskin C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20120212 PL - United States TA - Clin Appl Thromb Hemost JT - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis JID - 9508125 RN - 0 (Fibrinolytic Agents) RN - 0 (Plant Extracts) RN - 0 (ankaferd blood stopper) SB - IM CIN - Clin Appl Thromb Hemost. 2013 Jun;19(3):338-40. PMID: 22914810 MH - Adult MH - Aged MH - Female MH - Fibrinolytic Agents/*administration & dosage MH - Hemorrhage/*drug therapy MH - *Hemostatic Techniques MH - Humans MH - Male MH - Middle Aged MH - Plant Extracts/*administration & dosage/adverse effects MH - *Tooth Extraction EDAT- 2012/02/14 06:00 MHDA- 2013/07/09 06:00 CRDT- 2012/02/14 06:00 PHST- 2012/02/14 06:00 [entrez] PHST- 2012/02/14 06:00 [pubmed] PHST- 2013/07/09 06:00 [medline] AID - 1076029611435836 [pii] AID - 10.1177/1076029611435836 [doi] PST - ppublish SO - Clin Appl Thromb Hemost. 2013 Jan-Feb;19(1):96-9. doi: 10.1177/1076029611435836. Epub 2012 Feb 12. PMID- 25249172 OWN - NLM STAT- MEDLINE DCOM- 20150320 LR - 20171116 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 1 DP - 2015 Jan TI - Effect of low-concentration povidone iodine on postoperative complications after third molar surgery: a pilot split-mouth study. PG - 18-21 LID - S0278-2391(14)01113-6 [pii] LID - 10.1016/j.joms.2014.06.454 [doi] AB - PURPOSE: Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently. PATIENTS AND METHODS: A randomized controlled clinical trial was performed in 30 patients undergoing mandibular third molar removal in a split-mouth design. In the study group, a povidone iodine solution with a concentration of 0.5 mg/mL was used as the coolant and irrigant solution, whereas normal saline was used in the control group. Swelling (orotragus and mentotragus distances), trismus (maximum interincisal opening), and pain (visual analog scale score) were evaluated on postoperative days 2 and 7. RESULTS: In the study group, a significant decrease in swelling and trismus was observed at the 2 postoperative visits (P = .00) compared with the control group. The decrease of pain in the study group was not statistically significant at either postoperative visit (P > .05). More patients (63%) were subjectively satisfied with the side treated with povidone iodine. CONCLUSION: Povidone iodine irrigation is an inexpensive and safe method to lessen the postoperative sequelae of third molar surgery. CI - Copyright © 2015. Published by Elsevier Inc. FAU - Mahmoud Hashemi, Hamid AU - Mahmoud Hashemi H AD - Full Professor, Department of Oral and Maxillofacial Surgery, Tehran University of Medical Sciences, Tehran, Iran. FAU - Mohammadi, Farnoosh AU - Mohammadi F AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: farnooshmohammadi2003@gmail.com. FAU - Hasheminasab, Mahboube AU - Hasheminasab M AD - Resident, Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Mahmoud Hashemi, Ali AU - Mahmoud Hashemi A AD - General Dentist, Tehran, Iran. FAU - Zahraei, Shohreh AU - Zahraei S AD - General Dentist, Tehran, Iran. FAU - Mahmoud Hashemi, Talieh AU - Mahmoud Hashemi T AD - General Dentist, Tehran, Iran. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20140705 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Infective Agents, Local) RN - 451W47IQ8X (Sodium Chloride) RN - 85H0HZU99M (Povidone-Iodine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Infective Agents, Local/*administration & dosage MH - Edema/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Patient Satisfaction MH - Pilot Projects MH - Postoperative Complications/*prevention & control MH - Povidone-Iodine/*administration & dosage MH - Prospective Studies MH - Sodium Chloride MH - Therapeutic Irrigation/methods MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Visual Analog Scale MH - Young Adult EDAT- 2014/09/25 06:00 MHDA- 2015/03/21 06:00 CRDT- 2014/09/25 06:00 PHST- 2013/12/27 00:00 [received] PHST- 2014/06/27 00:00 [revised] PHST- 2014/06/30 00:00 [accepted] PHST- 2014/09/25 06:00 [entrez] PHST- 2014/09/25 06:00 [pubmed] PHST- 2015/03/21 06:00 [medline] AID - S0278-2391(14)01113-6 [pii] AID - 10.1016/j.joms.2014.06.454 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Jan;73(1):18-21. doi: 10.1016/j.joms.2014.06.454. Epub 2014 Jul 5. PMID- 15857102 OWN - NLM STAT- MEDLINE DCOM- 20050614 LR - 20081121 IS - 0022-3492 (Print) IS - 0022-3492 (Linking) VI - 76 IP - 4 DP - 2005 Apr TI - Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. PG - 605-13 AB - BACKGROUND: Conventional dentoalveolar osseous reconstruction often involves the use of grafting materials with or without barrier membranes. The purpose of this study was to evaluate the efficacy of bone induction for the placement of dental implants by two concentrations of recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a bioabsorbable collagen sponge (ACS) compared to placebo (ACS alone) and no treatment in a human buccal wall defect model following tooth extraction. METHODS: Eighty patients requiring local alveolar ridge augmentation for buccal wall defects (> or =50% buccal bone loss of the extraction socket) of the maxillary teeth (bicuspids forward) immediately following tooth extraction were enrolled. Two sequential cohorts of 40 patients each were randomized in a double-masked manner to receive 0.75 mg/ml or 1.50 mg/ml rhBMP-2/ACS, placebo (ACS alone), or no treatment in a 2:1:1 ratio. Efficacy was assessed by evaluating the amount of bone induction, the adequacy of the alveolar bone volume to support an endosseous dental implant, and the need for a secondary augmentation. RESULTS: Assessment of the alveolar bone indicated that patients treated with 1.50 mg/ml rhBMP-2/ACS had significantly greater bone augmentation compared to controls (P < or =0.05). The adequacy of bone for the placement of a dental implant was approximately twice as great in the rhBMP-2/ACS groups compared to no treatment or placebo. In addition, bone density and histology revealed no differences between newly induced and native bone. CONCLUSION: The data from this randomized, masked, placebo-controlled multicenter clinical study demonstrated that the novel combination of rhBMP-2 and a commonly utilized collagen sponge had a striking effect on de novo osseous formation for the placement of dental implants. FAU - Fiorellini, Joseph P AU - Fiorellini JP AD - Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA. joseph_fiorellini@hsdm.harvard.edu FAU - Howell, T Howard AU - Howell TH FAU - Cochran, David AU - Cochran D FAU - Malmquist, Jay AU - Malmquist J FAU - Lilly, Leslie C AU - Lilly LC FAU - Spagnoli, Daniel AU - Spagnoli D FAU - Toljanic, Joseph AU - Toljanic J FAU - Jones, Archie AU - Jones A FAU - Nevins, Myron AU - Nevins M LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 RN - 0 (BMP2 protein, human) RN - 0 (Bone Morphogenetic Protein 2) RN - 0 (Bone Morphogenetic Proteins) RN - 0 (Drug Carriers) RN - 0 (Recombinant Proteins) RN - 0 (Transforming Growth Factor beta) RN - 0 (recombinant human bone morphogenetic protein-2) RN - 9007-34-5 (Collagen) SB - D SB - IM MH - Absorbable Implants MH - Alveolar Bone Loss/etiology/*surgery MH - Alveolar Ridge Augmentation/methods MH - Analysis of Variance MH - Bone Density MH - Bone Morphogenetic Protein 2 MH - Bone Morphogenetic Proteins/administration & dosage/*pharmacology MH - Bone Regeneration/*drug effects MH - Collagen MH - Double-Blind Method MH - Drug Carriers MH - Female MH - Humans MH - Male MH - Middle Aged MH - Oral Surgical Procedures, Preprosthetic/adverse effects/*methods MH - Recombinant Proteins MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects MH - Tooth Socket/*surgery MH - Transforming Growth Factor beta/administration & dosage/*pharmacology EDAT- 2005/04/29 09:00 MHDA- 2005/06/15 09:00 CRDT- 2005/04/29 09:00 PHST- 2005/04/29 09:00 [pubmed] PHST- 2005/06/15 09:00 [medline] PHST- 2005/04/29 09:00 [entrez] AID - 10.1902/jop.2005.76.4.605 [doi] PST - ppublish SO - J Periodontol. 2005 Apr;76(4):605-13. doi: 10.1902/jop.2005.76.4.605. PMID- 27447802 OWN - NLM STAT- MEDLINE DCOM- 20171113 LR - 20181113 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 20 IP - 4 DP - 2016 Dec TI - Oral health-related quality of life following third molar surgery with either oral administration or submucosal injection of prednisolone. PG - 343-352 AB - AIM: The aim of this study was to evaluate the changes in oral health-related Quality of Life (QoL) following third molar surgery with either oral administration or submucosal injection of prednisolone. PATIENT AND METHODS: Subjects were randomly distributed into three groups of 62 subjects each: Group A consisted of subjects who received 40 mg oral prednisolone; group B received 40 mg submucosal injection of prednisolone, while group C did not receive prednisolone. Preoperative and postoperative quality of life evaluations of all subjects were done using the 14-item Oral Health Impact Profile (OHIP-14) questionnaire. Postoperatively, quality of life evaluation was done on postoperative days 1, 3, and 7. Subjects were categorized as either affected (OHIP score ≤28) or not affected (OHIP score >28). Mean OHIP scores between preoperative and postoperative periods, as well as between the three groups, were compared. RESULTS: A significant increase in the mean total and subscale scores was found in all the groups postoperatively. This was most marked on the first postoperative day, and it gradually improved throughout the immediate postoperative period. Subjects who received prednisolone experienced a statistically significant better quality of life than those who did not. Subjects who received submucosal injection of prednisolone showed statistically significant less deterioration in QoL than those who received oral prednisolone (P = 0.001). CONCLUSION: Administration of prednisolone was significantly associated with less deterioration in quality of life and earlier recovery when compared with subjects who did not receive prednisolone. Submucosal injection of prednisolone 40 mg (which offers a simple, safe, painless, and cost-effective therapeutic option) is an effective therapeutic strategy for improving the quality of life after surgical removal of impacted lower third molars. FAU - Ibikunle, Adebayo Aremu AU - Ibikunle AA AD - Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. adebayoibikunle@gmail.com. FAU - Adeyemo, Wasiu Lanre AU - Adeyemo WL AD - Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, College of Medicine University of Lagos, Lagos, Nigeria. FAU - Ladeinde, Akinola Ladipo AU - Ladeinde AL AD - Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, College of Medicine University of Lagos, Lagos, Nigeria. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20160722 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 9PHQ9Y1OLM (Prednisolone) SB - D SB - IM MH - Administration, Oral MH - Adult MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Mouth Mucosa/drug effects MH - *Oral Health MH - Postoperative Complications/prevention & control/psychology MH - Prednisolone/*administration & dosage MH - Quality of Life/*psychology MH - Surveys and Questionnaires MH - Tooth Extraction/*psychology MH - Visual Analog Scale MH - Young Adult OTO - NOTNLM OT - Quality of life OT - Submucosal prednisolone OT - Third molar extraction EDAT- 2016/07/23 06:00 MHDA- 2017/11/14 06:00 CRDT- 2016/07/23 06:00 PHST- 2016/02/14 00:00 [received] PHST- 2016/07/10 00:00 [accepted] PHST- 2016/07/23 06:00 [pubmed] PHST- 2017/11/14 06:00 [medline] PHST- 2016/07/23 06:00 [entrez] AID - 10.1007/s10006-016-0571-4 [pii] AID - 10.1007/s10006-016-0571-4 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2016 Dec;20(4):343-352. doi: 10.1007/s10006-016-0571-4. Epub 2016 Jul 22. PMID- 27054424 OWN - NLM STAT- MEDLINE DCOM- 20170609 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 27 IP - 3 DP - 2016 May TI - Periodontal Effects of a Transposed Versus a Conventional Flap in Mandibular Third Molar Extractions. PG - 708-11 LID - 10.1097/SCS.0000000000002541 [doi] AB - The aim of this study was to compare a transposed with a repositioned flap by assessing the periodontal effects on the second molar and primary healing after extraction of partially impacted lower third molars. A total of 24 patients requiring partially impacted mandibular wisdom tooth removal were enrolled in the study. The test group (n = 12) underwent a transposed flap procedure, whereas the control group (n = 12) underwent a repositioned flap procedure. Plaque index, probing depth, bleeding on probing, and width of keratinized tissue were recorded the day of surgery (T1) and after 60 days (T4). Wound dehiscence was assessed on the mesio-distal and bucco-lingual directions at days 2 (T2), 7 (T3), and T4. No significant differences have been observed in the periodontal parameters between the groups at T1 and T4 (P > 0.05). Similarly, no difference was found at T2, T3, and T4 in wound dehiscence incidence (P > 0.05). To date, no data exists on the use of transposed flaps in third molar surgery; thus a comparison of results cannot be done. Further studies with larger population are needed to investigate the potential advantages of this type of flap. FAU - Laurito, Domenica AU - Laurito D AD - *Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome†Department of Surgery, University of Pisa, Pisa‡Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. FAU - Lollobrigida, Marco AU - Lollobrigida M FAU - Graziani, Filippo AU - Graziani F FAU - Guerra, Fabrizio AU - Guerra F FAU - Vestri, Annarita AU - Vestri A FAU - De Biase, Alberto AU - De Biase A LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - D MH - Adolescent MH - Adult MH - Dental Plaque Index MH - Double-Blind Method MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Osteotomy/methods MH - *Surgical Flaps MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2016/04/08 06:00 MHDA- 2017/06/10 06:00 CRDT- 2016/04/08 06:00 PHST- 2016/04/08 06:00 [entrez] PHST- 2016/04/08 06:00 [pubmed] PHST- 2017/06/10 06:00 [medline] AID - 10.1097/SCS.0000000000002541 [doi] PST - ppublish SO - J Craniofac Surg. 2016 May;27(3):708-11. doi: 10.1097/SCS.0000000000002541. PMID- 25234524 OWN - NLM STAT- MEDLINE DCOM- 20141114 LR - 20140919 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 72 IP - 10 DP - 2014 Oct TI - A split-mouth randomized clinical trial to evaluate the performance of piezosurgery compared with traditional technique in lower wisdom tooth removal. PG - 1890-7 LID - S0278-2391(14)00501-1 [pii] LID - 10.1016/j.joms.2014.05.002 [doi] AB - PURPOSE: The surgical removal of mandibular third molars is frequently accompanied by significant postsurgical sequelae, and different protocols have been described to decrease such adverse events. The aim of this study was to investigate the performance of piezosurgery compared with traditional rotating instruments during mandibular third molar removal. PATIENTS AND METHODS: A single-center, randomized, split-mouth study was performed using a consecutive series of unrelated healthy patients attending the Oral Surgery Unit of the University of Turin for surgical removal of bilateral mandibular third molar teeth. Each patient was treated, at the same appointment, using bur removal on 1 side of the mandible and a piezoelectric device on the contralateral side. The primary outcomes reported were postoperative pain, objective orofacial swelling, and surgical duration; secondary outcomes were gender, age, and possible adverse events. Analysis of variance or paired t test was used as appropriate to test any significant differences at baseline according to each treatment subgroup, and categorical variables were analyzed by χ(2) test. RESULTS: The study sample consisted of 100 otherwise healthy patients. The mean pain evaluation reported by patients who underwent surgery with piezosurgery was significantly lower than that reported after bur (conventional) removal, reaching statistical difference after 4 days (P = .043). The clinical value of orofacial swelling at day 7, normalized to baseline, was lower in the piezosurgery group (P < .005). The average surgical duration was significantly shorter in the bur group than in the piezosurgery group (P < .05). Three patients having bur removal developed short-term complications (2 dry sockets and 1 temporary paraesthesia), which totally resolved by 4 weeks. CONCLUSIONS: To date, this prospective investigation is the largest reported split-mouth study on piezosurgery for lower third molar tooth removal. This study also compared surgeons with different degrees of experience. It is evident that using a piezoelectric device can enhance the patient experience and decrease postoperative pain and swelling. CI - Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Mantovani, Edoardo AU - Mantovani E AD - Clinician, Oral Surgery Unit, CIR-Dental School, University of Turin, Turin, Italy. FAU - Arduino, Paolo Giacomo AU - Arduino PG AD - Researcher, Oral Medicine Unit, CIR-Dental School, University of Turin, Turin, Italy. Electronic address: paologiacomo.arduino@unito.it. FAU - Schierano, Gianmario AU - Schierano G AD - Professor, Prosthodontics Unit, CIR-Dental School, University of Turin, Turin, Italy. FAU - Ferrero, Luca AU - Ferrero L AD - Clinician, Oral Surgery Unit, CIR-Dental School, University of Turin, Turin, Italy. FAU - Gallesio, Giorgia AU - Gallesio G AD - Clinician, Oral Surgery Unit, CIR-Dental School, University of Turin, Turin, Italy. FAU - Mozzati, Marco AU - Mozzati M AD - Clinician, Oral Surgery Unit, CIR-Dental School, University of Turin, Turin, Italy. FAU - Russo, Andrea AU - Russo A AD - Clinician, Oral Surgery Unit, CIR-Dental School, University of Turin, Turin, Italy. FAU - Scully, Crispian AU - Scully C AD - Professor, University College London, London, UK. FAU - Carossa, Stefano AU - Carossa S AD - Head, Prosthodontics Unit, CIR-Dental School, University of Turin, Turin, Italy. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20140513 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Clinical Competence MH - Dry Socket/etiology MH - Edema/etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Operative Time MH - Osteotomy/adverse effects/instrumentation/methods MH - Pain Measurement MH - Pain, Postoperative/etiology MH - Paresthesia/etiology MH - Piezosurgery/adverse effects/instrumentation/*methods MH - Postoperative Complications MH - Prospective Studies MH - Single-Blind Method MH - Tooth Extraction/adverse effects/instrumentation/*methods MH - Treatment Outcome MH - Young Adult EDAT- 2014/09/23 06:00 MHDA- 2014/11/15 06:00 CRDT- 2014/09/20 06:00 PHST- 2014/01/13 00:00 [received] PHST- 2014/04/28 00:00 [revised] PHST- 2014/05/03 00:00 [accepted] PHST- 2014/09/20 06:00 [entrez] PHST- 2014/09/23 06:00 [pubmed] PHST- 2014/11/15 06:00 [medline] AID - S0278-2391(14)00501-1 [pii] AID - 10.1016/j.joms.2014.05.002 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2014 Oct;72(10):1890-7. doi: 10.1016/j.joms.2014.05.002. Epub 2014 May 13. PMID- 24010986 OWN - NLM STAT- MEDLINE DCOM- 20140102 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 60 IP - 3 DP - 2013 Fall TI - Buccal injection of 2% lidocaine with epinephrine for the removal of maxillary third molars. PG - 95-8 LID - 10.2344/0003-3006-60.3.95 [doi] AB - The aim of the study was to demonstrate if 2% lidocaine hydrochloride with 1:200,000 epinephrine could provide palatal anesthesia in maxillary tooth removal with a single buccal injection. The subjects included in the clinical study were those requiring extraction of the maxillary third molar of either side. For the purpose of comparison, the sample was randomly divided into 2 main groups: group 1 (study group) included 100 subjects who were to receive a single injection before extraction, and group 2 (control group) included 100 subjects who were to receive a single buccal injection and a single palatal injection before extraction. After 5 minutes the extraction was performed. All patients were observed for Faces Pain Scale during extraction and asked for the same on a 100-mm visual analog scale after extraction. According to visual analog scale and Faces Pain Scale scores, when maxillary third molar removal without palatal injection (study group) and with palatal injection (control group) were compared the difference was not statistically significant (P > .05). Removal of maxillary third molars without palatal injection is possible by depositing 2 mL of 2% lidocaine hydrochloride with 1:200,000 epinephrine to the buccal vestibule of the tooth. FAU - Yadav, Sunil AU - Yadav S AD - Department of Oral & Maxillofacial Surgery, P.D.M. Dental College & Research Institute, Bahadurgarh, India. FAU - Verma, Ajay AU - Verma A FAU - Sachdeva, Akash AU - Sachdeva A LA - eng PT - Journal Article PT - Randomized Controlled Trial TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) SB - D MH - Administration, Buccal MH - Adult MH - Anesthesia, Dental/*methods MH - Anesthetics, Local/*administration & dosage MH - Facial Pain/prevention & control MH - Female MH - Humans MH - Injections MH - Lidocaine/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Palate, Hard MH - *Tooth Extraction PMC - PMC3771203 EDAT- 2013/09/10 06:00 MHDA- 2014/01/03 06:00 CRDT- 2013/09/10 06:00 PHST- 2013/09/10 06:00 [entrez] PHST- 2013/09/10 06:00 [pubmed] PHST- 2014/01/03 06:00 [medline] AID - 10.2344/0003-3006-60.3.95 [doi] PST - ppublish SO - Anesth Prog. 2013 Fall;60(3):95-8. doi: 10.2344/0003-3006-60.3.95. PMID- 16777382 OWN - NLM STAT- MEDLINE DCOM- 20060925 LR - 20171116 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 35 IP - 8 DP - 2006 Aug TI - Is povidone-iodine a hemostyptic? A clinical study. PG - 765-6 AB - Povidone-iodine (PVP-I) is an antiseptic agent commonly used on intact skin in preparation for surgery and on open wounds. In oral surgery it is used for irrigating alveolar sockets following extraction. The present authors found by chance that irrigation of extraction sockets with povidone-iodine led to cessation of bleeding in patients without recurrence. Fifty patients were selected and divided equally into treatment and control groups. Povidone-iodine (1%, w/v) was used for irrigation of extraction sockets in the treatment group and saline was used in the control group. In the treatment group, 19 patients showed cessation of bleeding compared to only 5 in the control group. Povidone-iodine significantly (P<0.01) controlled bleeding as compared to saline. Iodine is corrosive due to its oxidizing potential while povidone is a thickening and granulating agent; together they may have a chemocauterizing effect that could be the reason for the cessation of bleeding. These results suggest that povidone-iodine may act as a hemostyptic as well as an antiseptic. FAU - Kumar, B P R AU - Kumar BP AD - Department of Oral and Maxillofacial Surgery, College of Dental Surgery, Mangalore, Karnataka, India. FAU - Maddi, A AU - Maddi A FAU - Ramesh, K V AU - Ramesh KV FAU - Baliga, M J AU - Baliga MJ FAU - Rao, S N AU - Rao SN FAU - Meenakshi AU - Meenakshi LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20060614 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Hemostatics) RN - 85H0HZU99M (Povidone-Iodine) SB - D SB - IM CIN - Int J Oral Maxillofac Surg. 2007 Jan;36(1):97; author reply 98. PMID: 17112704 MH - Adolescent MH - Adult MH - Female MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/*drug therapy MH - Postoperative Hemorrhage/*drug therapy MH - Povidone-Iodine/*therapeutic use MH - Single-Blind Method MH - Tooth Extraction/adverse effects MH - Tooth Socket/*drug effects EDAT- 2006/06/17 09:00 MHDA- 2006/09/26 09:00 CRDT- 2006/06/17 09:00 PHST- 2002/08/06 00:00 [received] PHST- 2005/09/16 00:00 [revised] PHST- 2006/01/23 00:00 [accepted] PHST- 2006/06/17 09:00 [pubmed] PHST- 2006/09/26 09:00 [medline] PHST- 2006/06/17 09:00 [entrez] AID - S0901-5027(06)00074-9 [pii] AID - 10.1016/j.ijom.2006.01.015 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2006 Aug;35(8):765-6. doi: 10.1016/j.ijom.2006.01.015. Epub 2006 Jun 14. PMID- 18650545 OWN - NLM STAT- MEDLINE DCOM- 20080918 LR - 20170214 IS - 0022-0345 (Print) IS - 0022-0345 (Linking) VI - 87 IP - 8 DP - 2008 Aug TI - Aspirin use and post-operative bleeding from dental extractions. PG - 740-4 AB - Aspirin is a common, chronically administered preventive treatment for cardiovascular disease, but is often discontinued prior to invasive dental procedures because of concern for bleeding complications. We hypothesized that aspirin does not cause increased bleeding following a single tooth extraction. Thirty-six healthy persons requiring a tooth extraction were randomized to receive 325 mg/day aspirin or placebo for 4 days. Cutaneous bleeding time (BT) and platelet aggregation tests were obtained prior to extraction. The primary outcome measure, oral BT, and secondary bleeding outcomes were evaluated during and following extraction. No significant baseline differences, except for diastolic blood pressure, were found between groups. There were no differences in oral BT, cutaneous BT, secondary outcome measures, or compliance. Whole-blood aggregation results were significantly different between the aspirin and placebo groups. These findings suggest that there is no indication to discontinue aspirin for persons requiring single-tooth extraction. FAU - Brennan, M T AU - Brennan MT AD - Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA. mike.brennan@carolinas.org FAU - Valerin, M A AU - Valerin MA FAU - Noll, J L AU - Noll JL FAU - Napeñas, J J AU - Napeñas JJ FAU - Kent, M L AU - Kent ML FAU - Fox, P C AU - Fox PC FAU - Sasser, H C AU - Sasser HC FAU - Lockhart, P B AU - Lockhart PB LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Platelet Aggregation Inhibitors) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects MH - Aspirin/*adverse effects MH - Bleeding Time MH - Female MH - Hemostasis/drug effects MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/*etiology/prevention & control MH - Platelet Aggregation/drug effects MH - Platelet Aggregation Inhibitors/*adverse effects MH - Postoperative Hemorrhage/*etiology MH - Reference Values MH - Tooth Extraction/*adverse effects MH - Treatment Outcome EDAT- 2008/07/25 09:00 MHDA- 2008/09/19 09:00 CRDT- 2008/07/25 09:00 PHST- 2008/07/25 09:00 [pubmed] PHST- 2008/09/19 09:00 [medline] PHST- 2008/07/25 09:00 [entrez] AID - 87/8/740 [pii] AID - 10.1177/154405910808700814 [doi] PST - ppublish SO - J Dent Res. 2008 Aug;87(8):740-4. doi: 10.1177/154405910808700814. PMID- 6800046 OWN - NLM STAT- MEDLINE DCOM- 19820412 LR - 20131121 IS - 0347-9994 (Print) IS - 0347-9994 (Linking) VI - 5 IP - 5-6 DP - 1981 TI - A comparison of the effect of phenoxymethylpenicillin and azidocillin on postoperative complications after surgical removal of impacted mandibular third molars. PG - 225-34 AB - Postoperative complications after surgical removal of mandibular third molars are still a clinical problem. Sixty patients undergoing operations for removal of an impacted third mandibular molar, were included in a double blind study. Phenoxymethylpenicillin 800 mg, azidocillin 750 mg, or placebo were given to the patients pre-operatively and then twice per day for the following seven days. The concentrations of phenoxymethylpenicillin and azidocillin in serum and alveolar serum were measured and the postoperative courses - pain, trismus, swelling and wound-healing - were recorded. The 40 patients in the antibiotic groups responded significantly better with respect to wound-healing than the 20 patients in the placebo group, and there were no differences between phenoxymethylpenicillin and azidocillin. Antibiotics significantly reduced pain on day 7 postoperatively. There were no differences between antibiotic groups and placebo with respect to trismus and swelling. When the dental alveolar serum concentrations of phenoxymethylpenicillin 3.0 microgram/ml and azidocillin 7.9 microgram/ml were related to their range of inhibitory concentrations for microorganisms isolated from orofacial infections, it was noticed that the two drugs achieved levels sufficient to inhibit most strains. The effect of phenoxymethylpenicillin and azidocillin on postoperative infections can be of value after traumatic oral surgery or after operations on patients especially susceptible to infections. FAU - Bystedt, H AU - Bystedt H FAU - von Konow, L AU - von Konow L FAU - Nord, C E AU - Nord CE LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Sweden TA - Swed Dent J JT - Swedish dental journal JID - 7706129 RN - 0 (Penicillins) RN - Q42T66VG0C (Penicillin G) RN - R8XDP7L3SL (azidocillin) RN - Z61I075U2W (Penicillin V) SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Clinical Trials as Topic MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Microbial Sensitivity Tests MH - Middle Aged MH - Molar, Third/surgery MH - Penicillin G/*analogs & derivatives/blood/*therapeutic use MH - Penicillin V/blood/*therapeutic use MH - Penicillins/*therapeutic use MH - Postoperative Complications/*drug therapy MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery EDAT- 1981/01/01 00:00 MHDA- 1981/01/01 00:01 CRDT- 1981/01/01 00:00 PHST- 1981/01/01 00:00 [pubmed] PHST- 1981/01/01 00:01 [medline] PHST- 1981/01/01 00:00 [entrez] PST - ppublish SO - Swed Dent J. 1981;5(5-6):225-34. PMID- 14759109 OWN - NLM STAT- MEDLINE DCOM- 20040310 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 32 IP - 5 DP - 2003 Oct TI - Tranexamic acid mouthwash--a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions. PG - 504-7 AB - This prospective randomized study analyses the use of a prescribed 4.8% tranexamic acid post-operative mouthwash over 2 days vs 5 days to prevent bleeding in patients taking warfarin who require dental extractions. Eighty-five patients therapeutically anticoagulated with warfarin for various conditions, ranging in age from 21 to 86 years and requiring dental extractions, were randomly divided into two groups. Group A postoperatively received a 4.8% tranexamic acid mouthwash to be used over a 2-day period. Group B received the same mouthwash and instructions postoperatively, to be taken over 5 days. All procedures were performed on an ambulatory basis under local anaesthetic by the same surgeon. Patients were reviewed 1, 3, and 7 days postoperatively to assess bleeding. Eighty-two of the 85 patients encountered no postoperative problems. Two patients in group A and one in group B had minor postoperative bleeds that required minor ambulatory intervention to control. This study shows that a 2-day postoperative course of a 4.8% tranexamic acid mouthwash is as equally effective as a 5-day course in controlling haemostasis post-dental extractions in patient's anticoagulated with warfarin. FAU - Carter, G AU - Carter G AD - Oral and Maxillofacial Surgery Unit, University of Adelaide, Adelaide, South Australia. FAU - Goss, A AU - Goss A LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anticoagulants) RN - 0 (Antifibrinolytic Agents) RN - 0 (Mouthwashes) RN - 5Q7ZVV76EI (Warfarin) RN - 6T84R30KC1 (Tranexamic Acid) SB - D SB - IM MH - Administration, Topical MH - Adult MH - Aged MH - Anticoagulants/adverse effects MH - Antifibrinolytic Agents/*administration & dosage MH - *Dental Care for Chronically Ill MH - Female MH - Humans MH - Male MH - Middle Aged MH - Mouthwashes/*administration & dosage MH - Oral Hemorrhage/etiology/*prevention & control MH - Polypharmacy MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Prospective Studies MH - Single-Blind Method MH - Time Factors MH - Tooth Extraction MH - Tranexamic Acid/*administration & dosage MH - Warfarin/adverse effects EDAT- 2004/02/05 05:00 MHDA- 2004/03/11 05:00 CRDT- 2004/02/05 05:00 PHST- 2004/02/05 05:00 [pubmed] PHST- 2004/03/11 05:00 [medline] PHST- 2004/02/05 05:00 [entrez] PST - ppublish SO - Int J Oral Maxillofac Surg. 2003 Oct;32(5):504-7. PMID- 10323115 OWN - NLM STAT- MEDLINE DCOM- 19990518 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 43 IP - 4 DP - 1996 Fall TI - Analgesic and anti-inflammatory efficacy of tenoxicam and diclofenac sodium after third molar surgery. PG - 103-7 AB - Tenoxicam and diclofenac sodium were compared with each other for analgesic efficacy following removal of third molars under general anesthesia. Thirty-five healthy patients between the ages of 18 and 28 yr were randomly allocated to two groups to participate in this study. Patients in Group A (n = 17) received a single intravenous injection of tenoxicam 40 mg at induction of anesthesia, followed by a 20-mg tablet given in the evening of the day of the operation and thereafter, one 20-mg tablet daily from days 2 to 7. Group B (n = 18) received a single intramuscular injection of diclofenac sodium 75 mg at induction of anesthesia, followed by a 50-mg tablet 4 to 6 hr after the operation and again, between 2100 hr and 2200 hr the same day. Thereafter, a 50-mg tablet was taken 3 times daily for the next 6 days. Pain was measured hourly for the first 4 hr postoperatively, then at 21 hr, and thereafter in the morning and the evenings on days 2 to 7. The highest pain scores were obtained 1 hr postoperatively for both trial groups. At 1 and 2 hr postoperatively, no statistical significant differences in pain scores could be shown for both groups. However, at 3 and 4 hr postoperatively, patients in the tenoxicam group experienced significantly (P < or = 0.05) less pain than those in the diclofenac sodium group. On the evening of the third postoperative day, the tenoxicam group of patients experienced significantly less pain (P < or = 0.05) than those in the diclofenac sodium group. This was again the case on the morning of the fourth postoperative day. On the fifth, sixth, and seventh postoperative days, the average pain scores for patients in the tenoxicam group were statistically significantly lower, both mornings and evenings, than those in the diclofenac sodium group of patients (P = 0.05). FAU - Roelofse, J A AU - Roelofse JA AD - Division of Anesthesiology, University of Stellenbosch, Tygerberg, South Africa. FAU - Van der Bijl, P AU - Van der Bijl P FAU - Joubert, J J AU - Joubert JJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 144O8QL0L1 (Diclofenac) RN - Z1R9N0A399 (tenoxicam) SB - D MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anesthesia, Dental/*methods MH - Anesthesia, General MH - *Anti-Inflammatory Agents, Non-Steroidal MH - Chi-Square Distribution MH - *Diclofenac MH - Humans MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Piroxicam/*analogs & derivatives MH - Statistics, Nonparametric MH - Time Factors MH - *Tooth Extraction PMC - PMC2148775 EDAT- 1996/10/01 00:00 MHDA- 1999/05/14 00:01 CRDT- 1996/10/01 00:00 PHST- 1996/10/01 00:00 [pubmed] PHST- 1999/05/14 00:01 [medline] PHST- 1996/10/01 00:00 [entrez] PST - ppublish SO - Anesth Prog. 1996 Fall;43(4):103-7. PMID- 27159857 OWN - NLM STAT- MEDLINE DCOM- 20170307 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 27 IP - 3 DP - 2016 May TI - Efficacy of Anti-Inflammatory and Analgesic of Superpulsed Low Level Laser Therapy After Impacted Mandibular Third Molars Extractions. PG - 685-90 LID - 10.1097/SCS.0000000000002523 [doi] AB - The purpose of this study was to evaluate anti-inflammatory and analgesic efficacy of superpulsed low level laser therapy (SLLLT) after bilateral extraction of impacted mandibular third molars. Many studies in the literature show the anti-inflammatory and analgesic efficacy of laser therapy after oral surgery.The authors report the preliminary results of 25 patients who underwent bilateral extraction of mandibular eighths included in a single surgery. This is a split-mouth study, a site was randomized chosen to be treated with SLLLT at T0, 24 hours and 48 hours with a GaAs laser diode, whereas the other surgical site was evaluated as control. The suture was removed at 7 days and healing was controlled at 14 days. During the sessions were monitored and recorded the pain, using visual analog scale, and oedema with the visual analog scale and cephalometric measurements of cutaneous points (TR-GO, GO-CA, GO-SP, GO-PO). Each patient received only antibiotic prophylaxis and analgesic therapy as needed.Results indicate that in the treated site SLLLT determines a reduction in pain and swelling statistically significant compared with the control site (P < 0.05). The authors found that the effectiveness of laser therapy is in the first 5 days after surgery, showing a significant reduction of pain and swelling in the treated site than the control site.This study suggests that the SLLLT has a potential in reducing the postoperative discomfort after impacted third molar extractions, due to a reduction in postoperative pain and swelling. Superpulsed low level laser therapy has no side effects and is well tolerated by patients. It also seems to have a role in reducing the intake of drugs. FAU - Pol, Renato AU - Pol R AD - *Oral Surgery Unit, Dentistry Section, Department of Biomedical Sciences and Human Oncology, University of Turin †SIOM Oral Surgery and Implantology Center ‡Department of Surgical Sciences, University of Turin, Turin §Department of Health Sciences "A. Avogadro," University of Eastern Piedmont, Novara, Italy. FAU - Ruggiero, Tiziana AU - Ruggiero T FAU - Gallesio, Giorgia AU - Gallesio G FAU - Riso, Massimo AU - Riso M FAU - Bergamasco, Laura AU - Bergamasco L FAU - Mortellaro, Carmen AU - Mortellaro C FAU - Mozzati, Marco AU - Mozzati M LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - D MH - Adult MH - Analgesia/*methods MH - Edema/therapy MH - Female MH - Humans MH - Inflammation/*therapy MH - Low-Level Light Therapy/*methods MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*therapy MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2016/05/10 06:00 MHDA- 2017/03/08 06:00 CRDT- 2016/05/10 06:00 PHST- 2016/05/10 06:00 [entrez] PHST- 2016/05/10 06:00 [pubmed] PHST- 2017/03/08 06:00 [medline] AID - 00001665-201605000-00031 [pii] AID - 10.1097/SCS.0000000000002523 [doi] PST - ppublish SO - J Craniofac Surg. 2016 May;27(3):685-90. doi: 10.1097/SCS.0000000000002523. PMID- 25369393 OWN - NLM STAT- MEDLINE DCOM- 20160915 LR - 20141105 IS - 0363-6771 (Print) IS - 0363-6771 (Linking) VI - 62 IP - 6 DP - 2014 Nov-Dec TI - The efficacy of 2 different doses of dexamethasone to control postoperative swelling, trismus, and pain after third molar extractions. PG - e1-5 AB - This article addresses the effect of 2 different concentrations (4 and 12 mg) of dexamethasone to control pain, swelling, and trismus after third molar surgery. A clinical study was conducted with 27 male and female patients, all presenting with bilaterally displaced mandibular third molars. The treatment protocol required a surgical removal of each tooth in 2 separate operations. The patients were given a preoperative dose of dexamethasone-4 mg for one surgery, 12 mg for the other. The choice of which side would be operated on first and which dose of dexamethasone would be taken was performed randomly, under double-blind conditions. The trismus was assessed by measuring the interincisal distance. Pain intensity was measured both by the amount of painkillers (acetaminophen 750 mg) taken postsurgery and by the Visual Analogue Pain Scale. Data were collected 1 hour preoperative, then at 24 and 48 hours postoperative. A statistical analysis (student's t, Wilcoxon and Friedman tests) of the results showed no significant differences (α = 0.05) between the analyzed variables for the 2 doses of dexamethasone (4 and 12 mg). FAU - Agostinho, Cicero Newton Lemos Felicio AU - Agostinho CN FAU - da Silva, Vanessa Camila AU - da Silva VC FAU - Maia Filho, Etevaldo Matos AU - Maia Filho EM FAU - Cruz, Maria Luiza AU - Cruz ML FAU - Bastos, Eider Guimaraes AU - Bastos EG LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Gen Dent JT - General dentistry JID - 7610466 RN - 7S5I7G3JQL (Dexamethasone) SB - D MH - Adolescent MH - Adult MH - Dexamethasone/*administration & dosage MH - Dose-Response Relationship, Drug MH - Edema/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Trismus/*prevention & control MH - Young Adult EDAT- 2014/11/05 06:00 MHDA- 2016/09/16 06:00 CRDT- 2014/11/05 06:00 PHST- 2014/11/05 06:00 [entrez] PHST- 2014/11/05 06:00 [pubmed] PHST- 2016/09/16 06:00 [medline] PST - ppublish SO - Gen Dent. 2014 Nov-Dec;62(6):e1-5. PMID- 11213982 OWN - NLM STAT- MEDLINE DCOM- 20010301 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 59 IP - 2 DP - 2001 Feb TI - Thermographic imaging of postoperative inflammation modified by anti-inflammatory pretreatment. PG - 145-8; discussion 149-50 AB - PURPOSE: The aim of this study was to assess the usefulness of thermography in detecting the postoperative inflammatory reaction after third molar removal. PATIENTS AND METHODS: Thermographic images (NovaTherm; Novamedix Ltd, Hampshire, England) of both cheeks were obtained on the first and seventh postoperative days after removal of impacted mandibular third molars under local anesthesia in 30 patients (15 men, 15 women). The unoperated contralateral side served as a control. One of the following pretreatments was given immediately before the operation: diclofenac (Voltaren; Novartis, Espoo, Finland) 150 mg orally (rapid-release 50 mg and prolonged-release 100 mg, n = 15), diclofenac 100 mg orally (prolonged-release) and 50 mg intramuscularly (n = 11), or placebo (n = 4). RESULTS: The postoperative skin surface temperature on the operated side was significantly higher than that on the unoperated side. The thermal difference was 0.9 degrees C +/- 0.1 degrees C on the first postoperative day and declined significantly by the seventh day to 0.3 degrees C +/- 0.1 degrees C (both P < .001). The thermal difference in patients receiving diclofenac preoperatively was significantly smaller (0.8 degrees C +/- 0.1 degrees C at day 1 and 0.2 degrees C +/- 0.1 degrees C at day 7) than in patients receiving placebo (1.6 degrees C +/- 0.1 degrees C at day 1 and 0.8 degrees C +/- 0.3 degrees C at day 7, P < .001). However, with equal doses of diclofenac, the combination of rapid-release and prolonged-release tablets orally was more effective in reducing skin temperature than an orally administered prolonged-release tablet combined with intramuscular injection (P < .001). CONCLUSION: Thermography is a suitable method to measure the inflammatory reaction related to third molar removal. Thermal changes are significant and are decreased by the nonsteroidal anti-inflammatory drug diclofenac. FAU - Ventä, I AU - Ventä I AD - Department of Oral Medicine, University of Helsinki, Finland. Irja.Venta@helsinki.fi FAU - Hyrkäs, T AU - Hyrkäs T FAU - Paakkari, I AU - Paakkari I FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 144O8QL0L1 (Diclofenac) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage MH - Chemoprevention MH - Diclofenac/administration & dosage MH - Female MH - Humans MH - Inflammation/*diagnosis/*prevention & control MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Preoperative Care MH - Skin Temperature MH - *Thermography MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 2001/02/24 12:00 MHDA- 2001/03/07 10:01 CRDT- 2001/02/24 12:00 PHST- 2001/02/24 12:00 [pubmed] PHST- 2001/03/07 10:01 [medline] PHST- 2001/02/24 12:00 [entrez] AID - S0278-2391(01)70161-9 [pii] AID - 10.1053/joms.2001.20483 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2001 Feb;59(2):145-8; discussion 149-50. doi: 10.1053/joms.2001.20483. PMID- 33951173 OWN - NLM STAT- MEDLINE DCOM- 20210510 LR - 20210510 IS - 1053-4628 (Print) IS - 1053-4628 (Linking) VI - 45 IP - 2 DP - 2021 Apr 1 TI - Absorbable Hemostatic Pack Effect After Primary Incisor Extraction: A Pilot Study and Introduction of a Novel Scale to Assess Post-Operative Bleeding. PG - 67-73 LID - 10.17796/1053-4625-45.2.1 [doi] AB - OBJECTIVES: This pilot study compared hemostatic pack (HP) application with no intervention following extraction of maxillary primary incisors in healthy children for effect on bleeding time and influence of patient or tooth variables utilizing a novel scale for assessment of bleeding following extraction. STUDY DESIGN: A novel scale was created to assess bleeding after extraction. This scale was utilized in a randomized, split mouth study of healthy children ages 2-7 years old requiring extraction of at least 2 primary maxillary incisors under general anesthesia. One extraction site was randomly assigned to receive HP and the other had no hemostatic measures. Post-operative bleeding was rated at 2, 10, and 15 minutes post-extraction. Other variables recorded included age, sex, periapical radiolucency, presence of fistula, swelling, discoloration, intraoral stabilization device used, and vital signs at two time intervals. Pre-operative radiographs were reviewed for root resorption and periapical radiolucency. RESULTS AND CONCLUSIONS: Twenty-five patients provided 50 teeth. Hemostatic pack had a significant effect on reducing bleeding at each time point and that effect did not change over time. Age, sex, tooth pain, post-extraction heart rate, blood pressure, discoloration, amount of resorption, and presence of a periapical radiolucency had no significant effect on bleeding. The proposed bleeding scale had good intra-rater reliability and could be useful in future studies, once validated. FAU - Mattox, Shayna L AU - Mattox SL FAU - Hammersmith, Kimberly J AU - Hammersmith KJ FAU - Peng, Jin AU - Peng J FAU - Casamassimo, Paul S AU - Casamassimo PS FAU - Townsend, Janice A AU - Townsend JA LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Clin Pediatr Dent JT - The Journal of clinical pediatric dentistry JID - 9100079 RN - 0 (Hemostatics) SB - D MH - Child MH - Child, Preschool MH - *Hemostatics/therapeutic use MH - Humans MH - Incisor MH - Pilot Projects MH - Reproducibility of Results MH - *Root Resorption MH - Tooth Extraction OTO - NOTNLM OT - bleeding time OT - extractions OT - general anesthesia OT - hemostasis OT - hemostatic pack EDAT- 2021/05/06 06:00 MHDA- 2021/05/11 06:00 CRDT- 2021/05/05 17:51 PHST- 2021/05/05 17:51 [entrez] PHST- 2021/05/06 06:00 [pubmed] PHST- 2021/05/11 06:00 [medline] AID - 464789 [pii] AID - 10.17796/1053-4625-45.2.1 [doi] PST - ppublish SO - J Clin Pediatr Dent. 2021 Apr 1;45(2):67-73. doi: 10.17796/1053-4625-45.2.1. PMID- 20829150 OWN - NLM STAT- MEDLINE DCOM- 20101223 LR - 20100910 IS - 0363-6771 (Print) IS - 0363-6771 (Linking) VI - 58 IP - 5 DP - 2010 Sep-Oct TI - Can flap design influence the incidence of alveolar osteitis following removal of impacted mandibular third molars? PG - e187-9 AB - This study sought to evaluate the influence of flap design (that is, modified triangular flap or buccal envelope flap) on alveolar osteitis (AO) and on healing following the surgical removal of an impacted mandibular third molar. A double-blind split-mouth clinical trial examined 17 patients who were candidates for extraction of a bilaterally impacted mandibular third molar with the same difficulty index; a modified triangular flap was placed on one side and a buccal envelope flap (control) was placed on the other side. AO and healing were assessed at three and seven days after surgery. Data were analyzed with the McNemar and Wilcoxon signed-rank tests. The modified triangular flap decreased the incidence of AO and expedited healing at seven days postsurgery. In addition, statistically significant differences were observed in terms of both AO and postoperative healing. FAU - Haraji, Afshin AU - Haraji A AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Islamic Azad University, Tehran, Iran. FAU - Motamedi, Mohammed Hosein Kalantar AU - Motamedi MH FAU - Rezvani, Fatemeh AU - Rezvani F LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Gen Dent JT - General dentistry JID - 7610466 SB - D MH - Double-Blind Method MH - Dry Socket/*etiology/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Surgical Flaps/*classification MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Wound Healing/physiology MH - Young Adult EDAT- 2010/09/11 06:00 MHDA- 2010/12/25 06:00 CRDT- 2010/09/11 06:00 PHST- 2010/09/11 06:00 [entrez] PHST- 2010/09/11 06:00 [pubmed] PHST- 2010/12/25 06:00 [medline] PST - ppublish SO - Gen Dent. 2010 Sep-Oct;58(5):e187-9. PMID- 1519716 OWN - NLM STAT- MEDLINE DCOM- 19921007 LR - 20201209 IS - 0003-2409 (Print) IS - 0003-2409 (Linking) VI - 47 IP - 8 DP - 1992 Aug TI - A multiple dose comparison of combinations of ibuprofen and codeine and paracetamol, codeine and caffeine after third molar surgery. PG - 672-7 AB - In a randomised, double-blind, double-dummy, multiple dose, crossover study in 30 patients we compared an ibuprofen/codeine combination (400 mg ibuprofen/25.6 mg codeine phosphate) with a paracetamol/codeine/caffeine combination (1 g paracetamol/16 mg codeine phosphate/60 mg caffeine) for pain relief over 6 days after two-stage bilateral lower third molar removal. The ibuprofen combination produced significantly greater analgesia than the paracetamol combination, both on single-dose analysis of the first and second days and on multiple-dose measures for days 1, 2, 3 and 4. The mean incidence of adverse effects over the 6 days was 20% for both combinations. This trial design (crossover with multiple dosing in outpatients) is a sensitive way of testing for analgesia, and is potentially more predictive of adverse effect problems than single-dose studies. It confirms that multiple dosing may show increased efficacy. FAU - McQuay, H J AU - McQuay HJ AD - Oxford Regional Pain Relief Unit, Churchill Hospital. FAU - Carroll, D AU - Carroll D FAU - Guest, P AU - Guest P FAU - Juniper, R P AU - Juniper RP FAU - Moore, R A AU - Moore RA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Anaesthesia JT - Anaesthesia JID - 0370524 RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - 3G6A5W338E (Caffeine) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - IM MH - Acetaminophen/*administration & dosage/adverse effects MH - Administration, Oral MH - Adult MH - Caffeine/*administration & dosage MH - Codeine/*administration & dosage MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/*administration & dosage/adverse effects MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy EDAT- 1992/08/01 00:00 MHDA- 1992/08/01 00:01 CRDT- 1992/08/01 00:00 PHST- 1992/08/01 00:00 [pubmed] PHST- 1992/08/01 00:01 [medline] PHST- 1992/08/01 00:00 [entrez] AID - 10.1111/j.1365-2044.1992.tb02388.x [doi] PST - ppublish SO - Anaesthesia. 1992 Aug;47(8):672-7. doi: 10.1111/j.1365-2044.1992.tb02388.x. PMID- 23957018 OWN - NLM STAT- MEDLINE DCOM- 20140811 LR - 20190608 IS - 1918-1523 (Electronic) IS - 1203-6765 (Print) IS - 1203-6765 (Linking) VI - 18 IP - 6 DP - 2013 Nov-Dec TI - What constitutes a clinically important pain reduction in patients after third molar surgery? PG - 319-22 LID - 15205 [pii] AB - BACKGROUND: For patients with surgical third molar removal, it is unknown what constitutes a clinically important change in patients' visual analogue scale (VAS) reports of pain intensity. OBJECTIVES: To determine what constitutes a clinically important change in pain intensity on a VAS following surgical removal of the third molar. METHODS: The study population consisted of patients participating in three randomized trials. Patients were asked to rate their pain three times per day over a period of seven days on a 100 mm VAS after surgical removal of the third molar. Global Perceived Effect was measured on day 1 and day 7 and was used as the external criterion for assessing clinically important pain reduction. Global Perceived Effect scores of 6 ('much improved') or higher were classified as clinically 'successful', and scores of 5 ('slightly improved') or below were classified as clinically 'unsuccessful'. For each trial, the mean absolute and relative changes in VAS scores were calculated for both 'successful' and 'unsuccessful' treatments. Sensitivity and specificity analyses were performed. RESULTS: The patients who reported 'successful' pain reduction showed a relative pain reduction of ≥69% and an absolute pain reduction >2.5 cm on the VAS, whereas patients who classified their pain reduction as 'unsuccessful' had a relative pain reduction of ≤18.5% and an absolute pain reduction <0.5 cm on the VAS. Furthermore, sensitivity and specificity analyses showed that a cut-off point of ≥50% relative pain reduction exhibited the best balance of sensitivity and specificity. CONCLUSION: Relative pain reduction of ≥50% and an absolute pain reduction of ≥2.5 cm on the VAS were most accurate in predicting a successful pain reduction after a given treatment. FAU - Martin, Wilhelmus J J M AU - Martin WJ FAU - Ashton-James, C E AU - Ashton-James CE FAU - Skorpil, N E AU - Skorpil NE FAU - Heymans, M W AU - Heymans MW FAU - Forouzanfar, T AU - Forouzanfar T LA - eng PT - Journal Article DEP - 20130816 TA - Pain Res Manag JT - Pain research & management JID - 9612504 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Oral Surgical Procedures/*adverse effects MH - Pain/*etiology/prevention & control MH - *Pain Measurement MH - Randomized Controlled Trials as Topic MH - Sensitivity and Specificity MH - Young Adult PMC - PMC3917796 OAB - Publisher: Abstract available from the publisher. OABL- fre EDAT- 2013/08/21 06:00 MHDA- 2014/08/12 06:00 CRDT- 2013/08/20 06:00 PHST- 2013/08/20 06:00 [entrez] PHST- 2013/08/21 06:00 [pubmed] PHST- 2014/08/12 06:00 [medline] AID - 15205 [pii] AID - prm18319 [pii] AID - 10.1155/2013/742468 [doi] PST - ppublish SO - Pain Res Manag. 2013 Nov-Dec;18(6):319-22. doi: 10.1155/2013/742468. Epub 2013 Aug 16. PMID- 23866761 OWN - NLM STAT- MEDLINE DCOM- 20150312 LR - 20181113 IS - 1560-8115 (Print) IS - 2008-2231 (Electronic) IS - 1560-8115 (Linking) VI - 21 IP - 1 DP - 2013 Jul 18 TI - Effectiveness of green tea mouthwash in postoperative pain control following surgical removal of impacted third molars: double blind randomized clinical trial. PG - 59 LID - 10.1186/2008-2231-21-59 [doi] AB - BACKGROUND: Pain following surgical removal of impacted molars has remained an important concern among practitioners. Various protocols have been proposed to reduce postoperative pain. However, each one has special side effects and limitations. As green tea possesses anti-inflammatory and antibacterial properties, the aim of the current study was to evaluate the effectiveness of green tea mouthwash in controlling postoperative pain. MATERIALS AND METHODS: In a study with split-mouth and double blind design, 44 patients in need of bilateral removal of impacted third molars underwent randomized surgical extraction; following one surgery patients rinsed with a green tea mouthwash from the first to seventh postoperative day and after other extraction rinsed with placebo mouthwash in the same duration. Both patients and surgeon were blinded to the type of mouthwash. The predictor variable was type of mouthwash and primary outcome variable was postoperative pain measured by visual analogue scale (VAS) during first week after surgery. In addition, number of analgesics patients used after surgery recorded. To measure the effect of green tea mouthwash, repeated measures test with confidence interval of 95% was performed. RESULTS: Total of 43 patients with mean age of 24 years underwent total of 86 surgeries. VAS value had no statistically difference prior rinsing among groups (P-value > 0.05). However, the mean value of VAS following rinsing with green tea was statistically lower than placebo in postoperative days of 3-7 (P-value < 0.05). In addition, while rinsing with green tea, patients took significantly lower number of analgesics after surgery (P-value < 0.05). No side effects reported. CONCLUSION: Green tea mouthwash could be an appropriate and safe choice to control postoperative pain after third molar surgery. FAU - Eshghpour, Majid AU - Eshghpour M FAU - Mortazavi, Hamed AU - Mortazavi H FAU - Mohammadzadeh Rezaei, Naser AU - Mohammadzadeh Rezaei N FAU - Nejat, AmirHossein AU - Nejat A LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20130718 TA - Daru JT - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences JID - 101125969 RN - 0 (Analgesics) RN - 0 (Mouthwashes) RN - 0 (Plant Extracts) SB - IM MH - Adolescent MH - Adult MH - Analgesics/*therapeutic use MH - Camellia sinensis/*chemistry MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Mouthwashes/*therapeutic use MH - Pain, Postoperative/*drug therapy MH - Plant Extracts/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Young Adult PMC - PMC3720195 EDAT- 2013/07/23 06:00 MHDA- 2015/03/13 06:00 CRDT- 2013/07/23 06:00 PHST- 2013/04/28 00:00 [received] PHST- 2013/07/14 00:00 [accepted] PHST- 2013/07/23 06:00 [entrez] PHST- 2013/07/23 06:00 [pubmed] PHST- 2015/03/13 06:00 [medline] AID - 2008-2231-21-59 [pii] AID - 10.1186/2008-2231-21-59 [doi] PST - epublish SO - Daru. 2013 Jul 18;21(1):59. doi: 10.1186/2008-2231-21-59. PMID- 27420732 OWN - NLM STAT- MEDLINE DCOM- 20170323 LR - 20170323 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 34 IP - 9 DP - 2016 Sep TI - Effectiveness of Single Session of Low-Level Laser Therapy with a 940 nm Wavelength Diode Laser on Pain, Swelling, and Trismus After Impacted Third Molar Surgery. PG - 406-10 LID - 10.1089/pho.2016.4101 [doi] AB - INTRODUCTION: In low-level laser therapy (LLLT), applications are generally performed in repetitive sessions using wavelengths of around 800 nm, at which the depth of penetration of laser is greater. The present study aimed to investigate the effects of LLLT with a 940 nm diode laser, which was performed extraorally on all the primarily and secondarily affected areas immediately after surgery in a single session, on pain, swelling, and trismus that occurred after impacted tooth extraction. MATERIALS AND METHODS: Thirty-five outpatients with similarly impacted lower third molars on both sides were selected. The teeth of patients were removed in two separate operations. Postoperatively, the patients received laser therapy with energy of 4 J/cm(2) on one side and no laser energy was applied to the other side (placebo side). Swelling, trismus, and subjective assessment of pain on a visual analog scale were evaluated and compared between the laser-treated and placebo sides. RESULTS: There was no statistically significant difference in pain, swelling, or trismus between the sides (Mann-Whitney U test p > 0.05). However, according to the clinical outcomes, swelling and trismus were less in the laser-treated side than in the placebo side. CONCLUSIONS: A single-session LLLT that would be applied with a diode laser immediately after impacted tooth extraction might help patients to be less affected by postoperative trismus and swelling. FAU - Eroglu, Cennet Neslihan AU - Eroglu CN AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yuzuncu Yil University , Van, Turkey . FAU - Keskin Tunc, Serap AU - Keskin Tunc S AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yuzuncu Yil University , Van, Turkey . LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160715 PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 SB - IM MH - Adolescent MH - Adult MH - Edema/*prevention & control MH - Female MH - Humans MH - Lasers, Semiconductor MH - Low-Level Light Therapy/*instrumentation MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Single-Blind Method MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Trismus/*prevention & control EDAT- 2016/07/16 06:00 MHDA- 2017/03/24 06:00 CRDT- 2016/07/16 06:00 PHST- 2016/07/16 06:00 [entrez] PHST- 2016/07/16 06:00 [pubmed] PHST- 2017/03/24 06:00 [medline] AID - 10.1089/pho.2016.4101 [doi] PST - ppublish SO - Photomed Laser Surg. 2016 Sep;34(9):406-10. doi: 10.1089/pho.2016.4101. Epub 2016 Jul 15. PMID- 11735135 OWN - NLM STAT- MEDLINE DCOM- 20020423 LR - 20111117 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 39 IP - 6 DP - 2001 Dec TI - Nerve morbidity following wisdom tooth removal under local and general anaesthesia. PG - 419-22 AB - Two hundred and one patients had unilateral removal of the lower third molars under local anaesthesia and a further 234 patients had either bilateral or unilateral removal under general anaesthesia. A total of 634 lower third molars were extracted by four experienced surgeons (two consultants and two senior grade staff). All patients were reviewed independently 1-week postoperatively and any sensory disturbance and its location was recorded. Patients with sensory disturbance were subsequently reviewed at 1 month and again at 6 months if recovery was not complete. This study demonstrated little difference in the adverse event rate per tooth extracted between procedures under local and general anaesthesia. However, within the general anaesthetic group, the few unilateral procedures showed evidence of higher risk, but the number was too small for valid satisfactory analysis. The risk of nerve morbidity was also greater where the duration of the procedure was longer than 15 minutes in unilateral cases. CI - Copyright 2001 The British Association of Oral and Maxillofacial Surgeons. FAU - Hill, C M AU - Hill CM AD - Department of Oral Surgery, Medicine and Pathology, University of Wales, Cardiff CF4 4XY, UK. FAU - Mostafa, P AU - Mostafa P FAU - Thomas, D W AU - Thomas DW FAU - Newcombe, R G AU - Newcombe RG FAU - Walker, R V AU - Walker RV LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Adult MH - Anesthesia, Dental/*methods MH - *Anesthesia, General MH - *Anesthesia, Local MH - Cranial Nerve Injuries/*etiology MH - Female MH - Humans MH - Lingual Nerve Injuries MH - Lip MH - Logistic Models MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Prospective Studies MH - Somatosensory Disorders/*etiology MH - Tooth Extraction/*adverse effects/methods MH - Trigeminal Nerve Injuries EDAT- 2001/12/12 10:00 MHDA- 2002/04/24 10:01 CRDT- 2001/12/12 10:00 PHST- 2001/12/12 10:00 [pubmed] PHST- 2002/04/24 10:01 [medline] PHST- 2001/12/12 10:00 [entrez] AID - S0266-4356(01)90723-5 [pii] AID - 10.1054/bjom.2001.0723 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2001 Dec;39(6):419-22. doi: 10.1054/bjom.2001.0723. PMID- 22843310 OWN - NLM STAT- MEDLINE DCOM- 20131210 LR - 20181113 IS - 1435-604X (Electronic) IS - 0268-8921 (Linking) VI - 28 IP - 3 DP - 2013 May TI - Effect of low-level laser therapy after extraction of impacted lower third molars. PG - 845-9 LID - 10.1007/s10103-012-1174-4 [doi] AB - The aim of this study is to evaluate the effectiveness of the low-level laser therapy (LLLT) in the control of pain, swelling, and trismus associated with surgical removal of impacted lower third molars. Thirty patients were randomized into two treatment groups, each with 15 patients-group test (LLLT) and a group control (no-LLLT)-and were told to avoid any analgesics 12 h before the procedure. In group test, the 980-nm diode-laser (G-Laser 25 Galbiati, Italy) was applied, using a 600-μm handpiece, intraorally (lingual and vestibular) at 1 cm from the involved area and extraoral at the insertion point of the masseter muscle immediately after surgery and at 24 h. The group control received only routine management. Parameters used for LLLT were: continuous mode, at 300 mW (0.3 W) for a total of 180 s (60 s × 3) (0.3 W × 180 s=54 J). Group test showed improvement in the interincisal opening and remarkable reduction of trismus, swelling and intensity of pain on the first and the seventh postoperative days. Although LLLT has been reported to prevent swelling and trismus following the removal of impacted third molars, some of these studies reported a positive laser effect while others did not. All references to the use of laser therapy in the postoperative management of third molar surgery employ different methodologies and, in some, explanations as to selection of their respective radiation parameters are not given. This study has demonstrated that LLLT, with these parameters, is useful for the reduction of postoperative discomfort after third-molar surgery. FAU - Ferrante, Maurizio AU - Ferrante M AD - Dental Materials, Department of Oral Dental Diseases, University of Chieti-Italy, Via Vestini 31, 66013, Chieti, Italy. maurizio.ferrante@gmail.com FAU - Petrini, Morena AU - Petrini M FAU - Trentini, Paolo AU - Trentini P FAU - Perfetti, Giorgio AU - Perfetti G FAU - Spoto, Giuseppe AU - Spoto G LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20120728 PL - England TA - Lasers Med Sci JT - Lasers in medical science JID - 8611515 SB - IM MH - Adolescent MH - Adult MH - Edema/prevention & control MH - Female MH - Humans MH - Lasers, Semiconductor/therapeutic use MH - *Low-Level Light Therapy/methods MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/prevention & control MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Young Adult EDAT- 2012/07/31 06:00 MHDA- 2013/12/16 06:00 CRDT- 2012/07/31 06:00 PHST- 2012/03/20 00:00 [received] PHST- 2012/07/16 00:00 [accepted] PHST- 2012/07/31 06:00 [entrez] PHST- 2012/07/31 06:00 [pubmed] PHST- 2013/12/16 06:00 [medline] AID - 10.1007/s10103-012-1174-4 [doi] PST - ppublish SO - Lasers Med Sci. 2013 May;28(3):845-9. doi: 10.1007/s10103-012-1174-4. Epub 2012 Jul 28. PMID- 12820852 OWN - NLM STAT- MEDLINE DCOM- 20030708 LR - 20161124 IS - 0250-832X (Print) IS - 0250-832X (Linking) VI - 32 IP - 1 DP - 2003 Jan TI - Image quality of two solid-state and three photostimulable phosphor plate digital panoramic systems, and treatment planning of mandibular third molar removal. PG - 39-44 AB - OBJECTIVES: The purpose was to evaluate image quality of two solid-state (charge-coupled device (CCD)) and three photostimulable phosphor (PSP) plate digital panoramic systems, and to assess their utility for treatment planning before mandibular third molar removal. METHODS: 433 patients were randomly allocated to five digital systems: Dimax2 and Orthophos Plus (both CCD systems) and DenOptix, DigiDent and Digora (all PSP systems). Image quality was evaluated in six regions on a 4-point scale by three independent observers. In addition, an oral surgeon evaluated image quality in the mandibular third molar region only as well as the utility of the image for treatment planning before removal of that molar. RESULTS: Images from the DenOptix and DigiDent systems had a significantly lower overall quality than images from the Digora, Dimax2 and Orthophos Plus systems (P < 0.005). The oral surgeon's assessment of image utility resulted in rejection rates of 0% for Orthophos Plus, 2% for Digora, 8% for Dimax2, 12% for DigiDent and 14% for DenOptix images. The rates for the DigiDent and DenOptix images were significantly higher than those for the other systems (P < 0.001), and the rate for Dimax2 was significantly higher than that for Orthophos Plus (P = 0.002). CONCLUSIONS: The quality of DenOptix and DigiDent digital panoramic images was found to be inferior to the quality found in images obtained with the Digora, Dimax2 and Orthophos Plus systems. Images from the Digora and Orthophos Plus systems were regarded to be the most useful for treatment planning before mandibular third molar removal. FAU - Benediktsdottir, I S AU - Benediktsdottir IS AD - Department of Oral Radiology, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark. isb@odont.au.dk FAU - Hintze, H AU - Hintze H FAU - Petersen, J K AU - Petersen JK FAU - Wenzel, A AU - Wenzel A LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - D MH - Adolescent MH - Adult MH - Chi-Square Distribution MH - Female MH - Humans MH - Male MH - Mandible/diagnostic imaging MH - Molar, Third/*diagnostic imaging/surgery MH - Patient Care Planning MH - Radiography, Dental, Digital/*instrumentation/*methods MH - Radiography, Panoramic/instrumentation/*methods MH - Reproducibility of Results MH - Tooth Extraction MH - Tooth, Impacted/diagnostic imaging EDAT- 2003/06/25 05:00 MHDA- 2003/07/09 05:00 CRDT- 2003/06/25 05:00 PHST- 2003/06/25 05:00 [pubmed] PHST- 2003/07/09 05:00 [medline] PHST- 2003/06/25 05:00 [entrez] AID - 10.1259/dmfr/25838744 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 2003 Jan;32(1):39-44. doi: 10.1259/dmfr/25838744. PMID- 22916516 OWN - NLM STAT- MEDLINE DCOM- 20120911 LR - 20131121 IS - 0028-2715 (Print) IS - 0028-2715 (Linking) VI - 51 IP - 182 DP - 2011 Apr-Jun TI - Effect of submucosal injection of dexamethasone on post-operative sequelae of third molar surgery. PG - 72-8 AB - OBJECTIVE: This study was carried out to evaluate the effects of a single pre-operative sub-mucosal injection of dexamethasone after third molar surgery to see the effects on post-operative discomfort. METHODS: This study was a prospective, double-blind, randomized, clinical trial. The subjects were forty patients who underwent surgical removal of the mandibular impacted third molar under local anesthesia and after being randomly assigned to receive either an 8 mg dexamethasone as submucosal injection or a normal saline injection into the lower buccal vestibule adjacent to the third molar. The maximum interincisal distance and facial contours were measured at the baseline and post-surgically on Day 2 and 7. Post-operative pain was evaluated subjectively using a visual analog scale and objectively by counting the number of analgesic tablets used. All subjects were operated upon by the same investigator to minimize the difference from inter-operator variability. RESULTS: There was a significant difference in the measurements of the degree of swelling and trismus between the two groups on the 2nd post-operative day. In contrast, there was no statistically significant difference between the groups on the 7th post-operative day. The test group also used fewer analgesics post-operatively. CONCLUSIONS: Submucosal injection of dexamethasone after third molar surgery is effective in reducing postoperative swelling and trismus. It also delays the onset of post-operative pain. FAU - Deo, S P AU - Deo SP AD - National Medical College and Teaching Hospital, Birgunj, India. drsrjdeo@gmail.com LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Nepal TA - JNMA J Nepal Med Assoc JT - JNMA; journal of the Nepal Medical Association JID - 0045233 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) SB - IM MH - Adult MH - Anti-Inflammatory Agents/*administration & dosage MH - Dexamethasone/*administration & dosage MH - Edema/*prevention & control MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Prospective Studies MH - Young Adult EDAT- 2011/04/01 00:00 MHDA- 2012/09/12 06:00 CRDT- 2012/08/25 06:00 PHST- 2012/08/25 06:00 [entrez] PHST- 2011/04/01 00:00 [pubmed] PHST- 2012/09/12 06:00 [medline] PST - ppublish SO - JNMA J Nepal Med Assoc. 2011 Apr-Jun;51(182):72-8. PMID- 17982558 OWN - NLM STAT- MEDLINE DCOM- 20090210 LR - 20191110 IS - 1806-4760 (Electronic) IS - 0103-6440 (Linking) VI - 18 IP - 2 DP - 2007 TI - Electro-acupuncture efficacy on pain control after mandibular third molar surgery. PG - 158-62 AB - The aim of this study was to evaluate the efficacy of electro-acupuncture (EAC) on postoperative pain control after mandibular third molar surgery. Twenty four young patients (12 male and 12 female) with symmetrically impacted mandibular third molars were selected. Each patient was submitted to two separate surgical procedures under local anesthesia. At one side, extraction was carried out employing both prior (24h) and immediately postoperative application of EAC, while on the contralateral side surgery was carried out without any treatment. EAC was applied on 6 bilateral systemic and 2 auricular points with a WQ10Dl appliance using 40-60Hz frequency for 20 min and individually adjusted intensity. Postoperative pain intensity was rated on a 100 mm visual analog scale (VAS) between 2 and 72 h and recording the amount of analgesics intake after surgery. Statistical analysis was performed using theWilcoxon test. Postoperative pain VAS scores were significantly lower for the EAC group (p<0.05) and analgesic intake decreased (p<0.05) for all evaluated periods (p<0.05). Under the tested conditions EAC therapy is efficient was proved controlling postoperative pain following mandibular third molar surgical removal. FAU - Tavares, Marconi Gonzaga AU - Tavares MG AD - Department of Oral Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, SP, Brazil. FAU - Machado, Ana Paula AU - Machado AP FAU - Motta, Breno Gutierrez AU - Motta BG FAU - Borsatto, Maria Cristina AU - Borsatto MC FAU - Rosa, Adalberto Luiz AU - Rosa AL FAU - Xavier, Samuel Porfírio AU - Xavier SP LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Brazil TA - Braz Dent J JT - Brazilian dental journal JID - 9214652 RN - 0 (Analgesics) SB - D MH - Adolescent MH - Analgesics/therapeutic use MH - Anesthesia, Dental MH - Anesthesia, Local MH - *Electroacupuncture/instrumentation/methods MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Young Adult EDAT- 2007/11/06 09:00 MHDA- 2009/02/12 09:00 CRDT- 2007/11/06 09:00 PHST- 2007/03/06 00:00 [received] PHST- 2007/03/06 00:00 [accepted] PHST- 2007/11/06 09:00 [pubmed] PHST- 2009/02/12 09:00 [medline] PHST- 2007/11/06 09:00 [entrez] AID - S0103-64402007000200014 [pii] AID - 10.1590/s0103-64402007000200014 [doi] PST - ppublish SO - Braz Dent J. 2007;18(2):158-62. doi: 10.1590/s0103-64402007000200014. PMID- 21496998 OWN - NLM STAT- MEDLINE DCOM- 20110927 LR - 20201211 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 8 DP - 2011 Aug TI - Three-dimensional evaluation of postoperative swelling after third molar surgery using 2 different cooling therapy methods: a randomized observer-blind prospective study. PG - 2092-8 LID - 10.1016/j.joms.2010.12.038 [doi] AB - PURPOSE: In most cases, the removal of third molars leads to a significant degree of tissue trauma, resulting in common postoperative symptoms and signs of pain, facial swelling, dysfunction, and limited mouth opening (trismus). The beneficial effects of cold treatment on postoperative swelling, edema, pain, and inflammation, as well as the reduction in bleeding and hematomas, have been described. The aim of the present study was to compare postoperative cooling therapy using cooling compresses with that using the water-circulating cooling face mask by Hilotherm. We recorded the beneficial effects on postoperative facial swelling, pain, trismus, and neurologic complaints. PATIENTS AND METHODS: A total of 30 patients were scheduled to undergo third molar surgery and were divided randomly into 2 groups for treatment with either the Hilotherm or conventional cooling with cooling compresses. Cooling was performed one time for 45 minutes immediately after surgery. Facial swelling was quantified using a 3-dimensional optical scanning technique. The pain and neurologic scores and the degree of mouth opening were observed for each patient. RESULTS: Patients receiving cooling therapy using Hilotherm demonstrated less facial swelling, less pain, a tendency toward fewer neurologic complaints, and were more satisfied than the patients who had received conventional cooling. CONCLUSION: The results of our study have shown that the Hilotherm is more efficient for managing postoperative swelling and pain after the removal of third molars than conventional cooling using compresses. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Rana, Majeed AU - Rana M AD - Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany. rana.majeed@mh-hannover.de FAU - Gellrich, Nils-Claudius AU - Gellrich NC FAU - Ghassemi, Alireza AU - Ghassemi A FAU - Gerressen, Marcus AU - Gerressen M FAU - Riediger, Dieter AU - Riediger D FAU - Modabber, Ali AU - Modabber A LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110415 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Compression Bandages MH - Cryotherapy/instrumentation/*methods MH - Edema/*diagnosis/etiology MH - Equipment Design MH - Face/innervation MH - Female MH - Follow-Up Studies MH - Humans MH - Imaging, Three-Dimensional/instrumentation/*methods MH - Male MH - Masks MH - Molar, Third/*surgery MH - Optical Devices MH - Osteotomy/adverse effects MH - Pain Measurement MH - Pain, Postoperative/etiology MH - Patient Satisfaction MH - Postoperative Complications/*diagnosis MH - Prospective Studies MH - Range of Motion, Articular/physiology MH - Sensation Disorders/etiology MH - Single-Blind Method MH - Time Factors MH - *Tooth Extraction/adverse effects MH - Young Adult EDAT- 2011/04/19 06:00 MHDA- 2011/09/29 06:00 CRDT- 2011/04/19 06:00 PHST- 2010/08/06 00:00 [received] PHST- 2010/12/12 00:00 [revised] PHST- 2010/12/27 00:00 [accepted] PHST- 2011/04/19 06:00 [entrez] PHST- 2011/04/19 06:00 [pubmed] PHST- 2011/09/29 06:00 [medline] AID - S0278-2391(11)00062-0 [pii] AID - 10.1016/j.joms.2010.12.038 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Aug;69(8):2092-8. doi: 10.1016/j.joms.2010.12.038. Epub 2011 Apr 15. PMID- 9602959 OWN - NLM STAT- MEDLINE DCOM- 19980707 LR - 20190826 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 38 IP - 5 DP - 1998 May TI - Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients. PG - 447-54 AB - The purpose of this single-dose, randomized, placebo-controlled, and double-blind study was to evaluate the analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen after third molar surgery. Patients were instructed to take a single dose of either placebo or 50 mg, 100 mg, 200 mg, or 400 mg of ibuprofen when the postoperative pain was moderate to severe. Acetaminophen 500 mg was used as a rescue medication. Pain intensity, pain relief, and any possible adverse events were recorded on self-administered questionnaires hourly for 6 hours after intake of study medication. If rescue medication was taken, the time of intake was registered. A total of 304 patients entered the study, and 258 complied with the protocol. A positive analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen was observed when evaluated by pain intensity difference, sum of pain intensity difference, pain relief, total pain relief, and survival distribution of patients not taking rescue medication. Although significant pain relief was seen after a dose of 50 mg ibuprofen, ibuprofen 400 mg provided maximum pain relief and the longest duration of analgesic effect. Mild transient adverse events were reported by 6.8% of the patients. However, there was no significant difference in frequency between the placebo and 50 mg, 100 mg, 200 mg, and 400 mg ibuprofen dose groups. FAU - Schou, S AU - Schou S AD - Department of Oral, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark. FAU - Nielsen, H AU - Nielsen H FAU - Nattestad, A AU - Nattestad A FAU - Hillerup, S AU - Hillerup S FAU - Ritzau, M AU - Ritzau M FAU - Branebjerg, P E AU - Branebjerg PE FAU - Bugge, C AU - Bugge C FAU - Skoglund, L A AU - Skoglund LA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Adult MH - Analgesia MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain Measurement/drug effects MH - Pain, Postoperative/*drug therapy EDAT- 1998/05/29 00:00 MHDA- 1998/05/29 00:01 CRDT- 1998/05/29 00:00 PHST- 1998/05/29 00:00 [pubmed] PHST- 1998/05/29 00:01 [medline] PHST- 1998/05/29 00:00 [entrez] AID - 10.1002/j.1552-4604.1998.tb04452.x [doi] PST - ppublish SO - J Clin Pharmacol. 1998 May;38(5):447-54. doi: 10.1002/j.1552-4604.1998.tb04452.x. PMID- 17157479 OWN - NLM STAT- MEDLINE DCOM- 20070409 LR - 20151119 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 36 IP - 3 DP - 2007 Mar TI - Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. PG - 226-9 AB - Postoperative oedema is common following removal of impacted lower third molars. Several types of drug therapy (corticosteroids, non-steroidal anti-inflammatory drugs, enzymes) have been tried. The aim of this study was to compare the effectiveness of low-power laser (LPL) and dexamethasone after surgical removal of impacted lower third molars under local anaesthesia (2% lidocaine/epinephrine). MATERIAL AND METHODS: There were 120 healthy patients divided into four groups of 30 each. Group 1 received LPL irradiation immediately after operation (energy output 4 J/cm2 with constant power density of 50 mW, wavelength 637 nm); group 2 also received i.m. injection of 4 mg dexamethasone (Dexason) into the internal pterygoid muscle; group 3 received LPL irradiation supplemented by systemic dexamethasone (Dexason), 4 mg i.m. in the deltoid region, followed by 4 mg of dexamethasone intraorally 6h postoperatively; and the fourth (control) group received only the usual postoperative recommendations (cold packs, soft diet, etc.). RESULTS: LPL irradiation with local use of dexamethasone (group 2) resulted in a statistically significant reduction of postoperative oedema in comparison to the other groups. No adverse effects of the procedure or medication were observed. CONCLUSION: LPL irradiation after lower third molar surgery can be recommended to minimize swelling. The effect is enhanced by simultaneous local intramuscular use of dexamethasone. FAU - Markovic, A AU - Markovic A AD - Clinic of Oral Surgery, Faculty of Dentistry, Dr Subotica 4, 11000 Belgrade, Serbia. valentinam@sbb.co.yu FAU - Todorovic, Lj AU - Todorovic Lj LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article DEP - 20061208 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Administration, Oral MH - Anti-Inflammatory Agents/*administration & dosage MH - Combined Modality Therapy MH - Dexamethasone/*administration & dosage MH - Edema/etiology/*prevention & control MH - Humans MH - Injections, Intramuscular MH - *Low-Level Light Therapy MH - Mandible MH - Molar, Third/*surgery MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 2006/12/13 09:00 MHDA- 2007/04/10 09:00 CRDT- 2006/12/13 09:00 PHST- 2006/01/24 00:00 [received] PHST- 2006/09/14 00:00 [revised] PHST- 2006/10/16 00:00 [accepted] PHST- 2006/12/13 09:00 [pubmed] PHST- 2007/04/10 09:00 [medline] PHST- 2006/12/13 09:00 [entrez] AID - S0901-5027(06)00445-0 [pii] AID - 10.1016/j.ijom.2006.10.006 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2007 Mar;36(3):226-9. doi: 10.1016/j.ijom.2006.10.006. Epub 2006 Dec 8. PMID- 3909471 OWN - NLM STAT- MEDLINE DCOM- 19860128 LR - 20201209 IS - 0347-9994 (Print) IS - 0347-9994 (Linking) VI - 9 IP - 5 DP - 1985 TI - Acetylsalicylic acid compared with acetylsalicylic acid plus codeine as postoperative analgesics after removal of impacted mandibular third molars. PG - 207-12 AB - In a multicenter, double blind clinical trial a combination of acetylsalicylic acid 500 mg + codeine phosphate 30 mg has been compared with acetylsalicylic acid 500 mg as postoperative analgesics in patients with pain after surgical removal of impacted mandibular third molars. Evaluation of the results from 129 patients showed that the combination of acetylsalicylic acid and codeine provided better pain relief and also the number of tablets used was smaller and the time intervals between repeated doses were longer than with acetylsalicylic acid only. Adverse effects were few and similar for both drugs. It may be concluded that the combination of 500 mg acetylsalicylic acid and 30 mg codeine phosphate provides a useful analgesic for more severe pain conditions in oral surgery. FAU - Dahl, E AU - Dahl E FAU - Feldmann, G AU - Feldmann G FAU - Jönsson, E AU - Jönsson E LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Sweden TA - Swed Dent J JT - Swedish dental journal JID - 7706129 RN - 0 (Drug Combinations) RN - R16CO5Y76E (Aspirin) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Adolescent MH - Adult MH - Aspirin/administration & dosage/*therapeutic use MH - Clinical Trials as Topic MH - Codeine/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Humans MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 1985/01/01 00:00 MHDA- 1985/01/01 00:01 CRDT- 1985/01/01 00:00 PHST- 1985/01/01 00:00 [pubmed] PHST- 1985/01/01 00:01 [medline] PHST- 1985/01/01 00:00 [entrez] PST - ppublish SO - Swed Dent J. 1985;9(5):207-12. PMID- 15243609 OWN - NLM STAT- MEDLINE DCOM- 20040823 LR - 20141120 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 197 IP - 1 DP - 2004 Jul 10 TI - A prospective randomised cross-over study of the effect of local haemostasis after third molar surgery on facial swelling: an exploratory trial. PG - 42-4; discussion 32 AB - OBJECTIVE: This study was undertaken in order to evaluate the effects of local haemostasis on the facial swelling induced in patients undergoing surgical removal of impacted mandibular third molar teeth. DESIGN: A prospective randomised cross-over study. SETTING: Department of Oral and Maxillofacial Surgery, Samsun, Turkey, 2002. MATERIALS AND METHODS: Twenty-five healthy patients who were having bilaterally symmetric, impacted third molar extraction were studied. The teeth were removed in two separate operations by two surgeons who had equal academic degrees. The patients were assigned to test and control groups by random selection. One side served as control and on the other local haemostasis was achieved by a haemostatic agent (oxidised regenerated cellulose). This was placed into the socket following gauze packing for 3 minutes (test). The operating time therefore significantly increased in the test group. Data was collected regarding the operating time, mouth opening and facial swelling. RESULTS: There were no statistically significant differences between the test and control groups for the mean values of the facial swelling and mouth opening at day 1 and 3 post-operatively (P > 0.05). Operating time was statistically longer for the test group than the control (P < 0.001). CONCLUSION: This study has shown that establishment of local haemostasis after removal of impacted mandibular third molars is not so effective in preventing facial swelling. FAU - Alkan, A AU - Alkan A AD - Department of Oral and Maxillofacial Surgery, Ondokuz Mayis University, Samsun, Turkey. alpera@omu.edu.tr FAU - Metin, M AU - Metin M FAU - Arici, S AU - Arici S FAU - Sener, I AU - Sener I LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Cellulose, Oxidized) RN - 0 (Hemostatics) SB - D SB - IM MH - Adolescent MH - Adult MH - Cellulose, Oxidized/*therapeutic use MH - Cross-Over Studies MH - Edema/*prevention & control MH - Face MH - Female MH - Hemostatics/*therapeutic use MH - Humans MH - Male MH - Molar, Third/*surgery MH - Prospective Studies MH - Time Factors MH - *Tooth Extraction MH - Tooth Socket MH - Treatment Failure EDAT- 2004/07/10 05:00 MHDA- 2004/08/24 05:00 CRDT- 2004/07/10 05:00 PHST- 2002/12/20 00:00 [received] PHST- 2003/06/03 00:00 [accepted] PHST- 2004/07/10 05:00 [pubmed] PHST- 2004/08/24 05:00 [medline] PHST- 2004/07/10 05:00 [entrez] AID - 4811421 [pii] AID - 10.1038/sj.bdj.4811421 [doi] PST - ppublish SO - Br Dent J. 2004 Jul 10;197(1):42-4; discussion 32. doi: 10.1038/sj.bdj.4811421. PMID- 16998619 OWN - NLM STAT- MEDLINE DCOM- 20061129 LR - 20181113 IS - 1618-1247 (Print) IS - 1618-1247 (Linking) VI - 94 IP - 1 DP - 2006 Sep TI - Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery. PG - 59-63 AB - The objective of this study was to compare the pre-emptive analgesic effect of rofecoxib, a cyclooxygenase (COX)-2 inhibitor, with a more traditional and commonly used analgesic, ibuprofen, for mandibular third molar surgery, utilizing a prospective, randomized, double-blind, placebo-controlled clinical trial. Fifty-five healthy patients who were scheduled to undergo surgical removal of an impacted mandibular third molar as outpatients at one of two government dental clinics in Fiji were enrolled. The patients were divided randomly into three groups to receive 50 mg rofecoxib or 400 mg ibuprofen, or a placebo 1 h prior to surgery. A dose of 1000 mg paracetamol was offered as rescue medication. Participants recorded their pain intensity on a 10-cm visual analogue scale 1 h before and just prior to surgery and every 30 min for 6 h following surgery. There were no significant analgesic differences between rofecoxib and ibuprofen at any time intervals postoperatively. Ibuprofen was significantly better at reducing pain at all time intervals by comparison with the placebo. Rofecoxib provided significantly better pain relief compared with the placebo, except at 60, 180, and 240 min postoperatively. Rescue medication use was significantly lower in the rofecoxib and ibuprofen groups by comparison with the placebo group; however, there was no significant difference between the two therapeutic groups. Rescue medication was used by 50%, 25%, and 94% of patients receiving rofecoxib, ibuprofen, and placebo, respectively. Ibuprofen, a commonly used over-the-counter analgesic, is as effective as rofecoxib for the relief of acute postoperative pain following third molar surgery when used pre-emptively. FAU - Morse, Zac AU - Morse Z AD - The Fiji School of Medicine, School of Oral Health, Private Mail Bag, Suva, Fiji Islands. zacmorse@hotmail.com FAU - Tump, Anna AU - Tump A FAU - Kevelham, Ester AU - Kevelham E LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Japan TA - Odontology JT - Odontology JID - 101134822 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Lactones) RN - 0 (Sulfones) RN - 0QTW8Z7MCR (rofecoxib) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Cyclooxygenase 2 Inhibitors/administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/*administration & dosage MH - Lactones/*administration & dosage MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Premedication MH - Prospective Studies MH - Statistics, Nonparametric MH - Sulfones/*administration & dosage MH - *Tooth Extraction EDAT- 2006/09/26 09:00 MHDA- 2006/12/09 09:00 CRDT- 2006/09/26 09:00 PHST- 2005/11/15 00:00 [received] PHST- 2006/05/12 00:00 [accepted] PHST- 2006/09/26 09:00 [pubmed] PHST- 2006/12/09 09:00 [medline] PHST- 2006/09/26 09:00 [entrez] AID - 10.1007/s10266-006-0062-4 [doi] PST - ppublish SO - Odontology. 2006 Sep;94(1):59-63. doi: 10.1007/s10266-006-0062-4. PMID- 33523087 OWN - NLM STAT- MEDLINE DCOM- 20210219 LR - 20210219 IS - 1852-4834 (Electronic) IS - 0326-4815 (Linking) VI - 33 IP - 3 DP - 2020 Dec 1 TI - A comparative analysis between atraumatic and conventional anesthetic techniques in surgical removal of upper third molars. PG - 216-220 AB - Pain control is essential in dental practice, and can be accomplished through various techniques. This study seeks to compare atraumatic and conventional anesthetic techniques, applied during surgeries to remove upper third molars. The endpoints evaluated were pain indices, patient satisfaction and anesthetic efficacy. A random parallel split-mouth clinical trial was conducted with 14 patients. Group A received atraumatic anesthesia without a needle (Comfort-in®) and group B received conventional anesthesia by blocking the posterior superior alveolar nerve (PSAN) and Greater Palatine Nerve (GPN). A Visual Analogue Scale (VAS) was used to assess pain. A significantly (p<0.001) lower perception of pain was observed among individuals who received the atraumatic technique. In 71% of cases, it was necessary to supplement the anesthesia during the procedure. Even considering the need for additional anesthesia, the Comfort-in® technique was more accepted by patients with regard to pain perception than the conventional manual technique. CI - Sociedad Argentina de Investigación Odontológica. FAU - Donato, Luís Pl AU - Donato LP AD - Centro de Ensino Superior Maceió; Graduação em Odontologia, Alagoas, Brasil. FAU - Maciel, Marcela M AU - Maciel MM AD - Centro de Ensino Superior Maceió; Graduação em Odontologia, Alagoas, Brasil. FAU - Maciel, Luiza M AU - Maciel LM AD - Centro de Ensino Superior Maceió; Graduação em Odontologia, Alagoas, Brasil. FAU - Lopes, Lívia M AU - Lopes LM AD - Universidade Federal de Pernambuco; Programa de Pós-Graduação em Odontologia, Pernambuco, Brasil. FAU - Carvalho, Alessandra de At AU - Carvalho AA AD - Universidade Federal de Pernambuco; Programa de Pós-Graduação em Odontologia, Pernambuco, Brasil. FAU - de Oliveira, Hugo Fl AU - de Oliveira HF AD - Universidade de Pernambuco; Programa de Odontologia, Pernambuco, Brasil. FAU - Rebelo, Hélder L AU - Rebelo HL AD - Universidade Federal de Pernambuco; Programa de Pós-Graduação em Odontologia, Pernambuco, Brasil. LA - eng PT - Journal Article PT - Randomized Controlled Trial TT - Análise comparativa entre a técnica anestésica atraumática e convencional em cirurgia para remoção dos terceiros molares superiores. PL - Argentina TA - Acta Odontol Latinoam JT - Acta odontologica latinoamericana : AOL JID - 8610218 RN - 0 (Anesthetics, Local) SB - D MH - *Anesthesia, Dental MH - Anesthetics, Local MH - Humans MH - Molar, Third/*surgery MH - *Nerve Block MH - Tooth Extraction/*methods OTO - NOTNLM OT - anesthesia, dental OT - pain management OT - patient satisfaction COIS- none EDAT- 2021/02/02 06:00 MHDA- 2021/02/20 06:00 CRDT- 2021/02/01 12:18 PHST- 2020/09/01 00:00 [received] PHST- 2020/11/01 00:00 [accepted] PHST- 2021/02/01 12:18 [entrez] PHST- 2021/02/02 06:00 [pubmed] PHST- 2021/02/20 06:00 [medline] PST - ppublish SO - Acta Odontol Latinoam. 2020 Dec 1;33(3):216-220. PMID- 16457912 OWN - NLM STAT- MEDLINE DCOM- 20070130 LR - 20131121 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 44 IP - 6 DP - 2006 Dec TI - Bupivacaine as pre-emptive analgesia in third molar surgery: Randomised controlled trial. PG - 501-3 AB - We conducted a prospective, randomised study on the use of pre-emptive analgesia in 45 patients who had bilateral impacted third molars removed. Bupivacaine 0.5% with adrenaline 1:200,000 was injected on one side, the other side acting as control. A visual analogue scale was used to measure the extent of postoperative pain. There was a significant reduction (p = 0.05) in postoperative pain on the injected side at 6, 12, and 72 h and an overall reduction in pain up to 7 days. FAU - Nayyar, M Sharif AU - Nayyar MS AD - National Maxillofacial Unit, Registrar Maxillofacial Unit, St James Hospital, Dublin 8, Republic of Ireland. sharifnayyar@hotmail.com FAU - Yates, C AU - Yates C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20060202 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anesthetics, Local) RN - Y8335394RO (Bupivacaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental MH - Anesthetics, Local/*administration & dosage MH - Bupivacaine/*administration & dosage MH - Female MH - Follow-Up Studies MH - Humans MH - Hypesthesia/chemically induced MH - Lingual Nerve/drug effects MH - Lip/innervation MH - Male MH - Mandibular Nerve/drug effects MH - Molar, Third/*surgery MH - Nerve Block MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications MH - Prospective Studies MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2006/02/07 09:00 MHDA- 2007/01/31 09:00 CRDT- 2006/02/07 09:00 PHST- 2004/11/18 00:00 [received] PHST- 2005/09/07 00:00 [accepted] PHST- 2006/02/07 09:00 [pubmed] PHST- 2007/01/31 09:00 [medline] PHST- 2006/02/07 09:00 [entrez] AID - S0266-4356(05)00299-8 [pii] AID - 10.1016/j.bjoms.2005.09.012 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2006 Dec;44(6):501-3. doi: 10.1016/j.bjoms.2005.09.012. Epub 2006 Feb 2. PMID- 22705219 OWN - NLM STAT- MEDLINE DCOM- 20121130 LR - 20161125 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 70 IP - 10 DP - 2012 Oct TI - Inferior alveolar nerve sensory disturbance after impacted mandibular third molar evaluation using cone beam computed tomography and panoramic radiography: a pilot study. PG - 2264-70 LID - S0278-2391(12)00505-8 [pii] LID - 10.1016/j.joms.2012.04.015 [doi] AB - PURPOSE: To measure sensory disturbances of the inferior alveolar nerve (IAN) after removal of impacted mandibular third molars using cone beam computed tomography (CBCT) and dental panoramic radiography (PAN) for preoperative assessment in a randomized controlled trial and to measure the efficacy of the observers' prediction of IAN exposure at surgery based on CBCT compared with PAN. MATERIALS AND METHODS: The sample consisted of 86 impacted third molars (from 79 consecutive patients) in close relation to the IAN as determined by PAN and judged as showing a "moderate" risk of IAN damage. Cases presenting with no close relation between the IAN and roots and extremely risky cases with an obvious interrelation were excluded. Potential neurosensory disturbances of the lip and chin were assessed before surgery and during the postoperative recall by measuring the function of the IAN with the light-touch sensation method. RESULTS: Postoperative sensory disturbances occurred in 1 patient in the CBCT group and 1 patient in the PAN group. The light-touch sensation test showed no significant differences at the lip (P = .10) and chin (P = .17) levels for CBCT- versus PAN-based surgery. Significant differences in making a correct diagnosis of neurovascular bundle exposure at the extraction of impacted teeth were found between the 2 modalities (P = .029). CONCLUSIONS: Within the limits of the present pilot study, CBCT was not superior to PAN in predicting postoperative sensory disturbances but was superior in predicting IAN exposure during third molar removal in cases judged as having "moderate" risk. CI - Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Guerrero, Maria Eugenia AU - Guerrero ME AD - Oral Imaging Center, Department of Oral Health Sciences, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium. reinhilde.jacobs@uzleuven.be FAU - Nackaerts, Olivia AU - Nackaerts O FAU - Beinsberger, Jilke AU - Beinsberger J FAU - Horner, Keith AU - Horner K FAU - Schoenaers, Joseph AU - Schoenaers J FAU - Jacobs, Reinhilde AU - Jacobs R CN - SEDENTEXCT Project Consortium LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120616 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Chin/innervation MH - Cone-Beam Computed Tomography/*methods MH - Follow-Up Studies MH - Forecasting MH - Humans MH - Lip/innervation MH - Mandibular Nerve/*diagnostic imaging/pathology MH - Molar, Third/diagnostic imaging/innervation/*surgery MH - Patient Care Planning MH - Pilot Projects MH - Postoperative Complications MH - Radiography, Dental, Digital/methods MH - Radiography, Panoramic/*methods MH - Risk Assessment MH - Sensory Thresholds/physiology MH - Somatosensory Disorders/*etiology MH - Tooth Extraction/adverse effects MH - Tooth Socket/innervation/surgery MH - Tooth, Impacted/diagnostic imaging/*surgery MH - Touch/physiology MH - Treatment Outcome MH - Trigeminal Nerve Injuries/*etiology EDAT- 2012/06/19 06:00 MHDA- 2012/12/10 06:00 CRDT- 2012/06/19 06:00 PHST- 2011/12/19 00:00 [received] PHST- 2012/04/17 00:00 [revised] PHST- 2012/04/18 00:00 [accepted] PHST- 2012/06/19 06:00 [entrez] PHST- 2012/06/19 06:00 [pubmed] PHST- 2012/12/10 06:00 [medline] AID - S0278-2391(12)00505-8 [pii] AID - 10.1016/j.joms.2012.04.015 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2012 Oct;70(10):2264-70. doi: 10.1016/j.joms.2012.04.015. Epub 2012 Jun 16. PMID- 9497707 OWN - NLM STAT- MEDLINE DCOM- 19980818 LR - 20161124 IS - 0198-7569 (Print) IS - 0198-7569 (Linking) VI - 17 IP - 2 DP - 1997 Apr TI - A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. PG - 124-39 AB - This two-center human clinical trial evaluated recombinant human bone morphogenetic protein-2 delivered in an absorbable collagen sponge (rhBMP-2/ACS) for either alveolar ridge preservation after tooth extraction or augmentation of localized osseous defects. This 24-month study comprised two parts: a 4-month acute safety and bone induction period (Part I) followed by a 20-month, osseointegration, functional restoration, and long-term safety evaluation (Part II). The primary objective of Part I, discussed in this article, was to evaluate the short-term safety and technical feasibility of the rhBMP-2 device implantation. Twelve patients (six preservation and six augmentation) were enrolled in the investigation. Patient safety was monitored by oral examinations, radiographs, and the collection of blood samples to measure serum chemistries, hematology, and potential antibody formation. Technical feasibility was evaluated by collecting information relating to the handling properties of the rhBMP-2/ACS device. The ability of various evaluative tools to measure the bone-inducing activity of the rhBMP-2/ACS device was also assessed. The clinical results suggested that rhBMP-2/ACS was well tolerated locally and systemically, with no serious adverse events. The device was found to be easily handled and adapted to the ridge and extraction socket. Using direct measurements, all sites demonstrated firmness and fullness to palpation at 4 weeks; however, a loss of volume was noted in some treatment areas between 4 and 8 weeks. Augmentation of the alveolar ridge was not observed in the patients as assessed by the evaluation techniques. This trial indicated that the use of rhBMP-2/ACS to preserve alveolar ridge after tooth extraction or augmentation of localized defects is safe and feasible. Bone fill was observed in all alveolar sockets filled with the rhBMP-2 device. FAU - Howell, T H AU - Howell TH AD - Harvard School of Dental Medicine, Cambridge, Massachusetts, USA. FAU - Fiorellini, J AU - Fiorellini J FAU - Jones, A AU - Jones A FAU - Alder, M AU - Alder M FAU - Nummikoski, P AU - Nummikoski P FAU - Lazaro, M AU - Lazaro M FAU - Lilly, L AU - Lilly L FAU - Cochran, D AU - Cochran D LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Multicenter Study PL - United States TA - Int J Periodontics Restorative Dent JT - The International journal of periodontics & restorative dentistry JID - 8200894 RN - 0 (BMP2 protein, human) RN - 0 (Bone Morphogenetic Protein 2) RN - 0 (Bone Morphogenetic Proteins) RN - 0 (Drug Carriers) RN - 0 (Drug Implants) RN - 0 (Recombinant Proteins) RN - 0 (Transforming Growth Factor beta) RN - 0 (recombinant human bone morphogenetic protein-2) RN - 9007-34-5 (Collagen) SB - D MH - Absorption MH - Adult MH - Alveolar Process/diagnostic imaging/surgery MH - Alveolar Ridge Augmentation/*instrumentation/methods MH - Animals MH - Bone Morphogenetic Protein 2 MH - Bone Morphogenetic Proteins/adverse effects/*therapeutic use MH - Collagen/adverse effects/*therapeutic use MH - Drug Carriers MH - Drug Implants MH - Feasibility Studies MH - Humans MH - Prospective Studies MH - Radiography MH - Recombinant Proteins/adverse effects/therapeutic use MH - Tooth Extraction MH - Transforming Growth Factor beta/adverse effects/*therapeutic use EDAT- 1997/04/01 00:00 MHDA- 1998/03/14 00:01 CRDT- 1997/04/01 00:00 PHST- 1997/04/01 00:00 [pubmed] PHST- 1998/03/14 00:01 [medline] PHST- 1997/04/01 00:00 [entrez] PST - ppublish SO - Int J Periodontics Restorative Dent. 1997 Apr;17(2):124-39. PMID- 8419869 OWN - NLM STAT- MEDLINE DCOM- 19930208 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 75 IP - 1 DP - 1993 Jan TI - Tranexamic acid as a mouthwash in anticoagulant-treated patients undergoing oral surgery. An alternative method to discontinuing anticoagulant therapy. PG - 29-31 AB - A double-blind randomized study was carried out to evaluate the clinical hemostatic effect of tranexamic acid mouthwash after dental extraction in 30 patients who received anticoagulant agents. Surgery was performed with a reduction in the level of anticoagulant therapy in the control group and with no change in the level of anticoagulant therapy in the group who received the tranexamic acid. After the extraction the surgical field was irrigated with a 5% solution of tranexamic acid in the group of 15 patients whose anticoagulant treatment had not been discontinued and with a placebo solution in the group of 15 patients for whom the anticoagulant therapy was reduced. Patients were instructed to rinse their mouths with 10 ml of the assigned solution for 2 minutes four times a day for 7 days. There was no significant difference between the two treatment groups in the bleeding incidence after oral surgery. We conclude that the anticoagulant treatment does not need to be withdrawn before oral surgery provided that local antifibrinolytic therapy is instituted. FAU - Borea, G AU - Borea G AD - Department of Dentistry, University of Bologna, Italy. FAU - Montebugnoli, L AU - Montebugnoli L FAU - Capuzzi, P AU - Capuzzi P FAU - Magelli, C AU - Magelli C LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Anticoagulants) RN - 0 (Mouthwashes) RN - 6T84R30KC1 (Tranexamic Acid) SB - D SB - IM MH - Anticoagulants/*therapeutic use MH - Blood Loss, Surgical/*prevention & control MH - *Dental Care for Disabled MH - Double-Blind Method MH - Female MH - Heart Valve Prosthesis MH - Humans MH - Male MH - Middle Aged MH - Mouthwashes/therapeutic use MH - Oral Hemorrhage/*prevention & control MH - Tooth Extraction MH - Tranexamic Acid/*administration & dosage/therapeutic use EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 10.1016/0030-4220(93)90401-o [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1993 Jan;75(1):29-31. doi: 10.1016/0030-4220(93)90401-o. PMID- 18091666 OWN - NLM STAT- MEDLINE DCOM- 20080715 LR - 20080819 IS - 0026-4970 (Print) IS - 0026-4970 (Linking) VI - 56 IP - 10 DP - 2007 Oct TI - Use of resorbable membranes in periodontal defects treatment after extraction of impacted mandibular third molars. PG - 497-508 AB - AIM: The aim of this study was to evaluate the efficacy of guided-tissue regeneration therapy (GTR) in the treatment of periodontal defects on the distal surface of mandibular second molars following surgical extraction of impacted third molars. METHODS: This split-mouth design study included 11 subjects who required extraction of bilateral impacted mandibular third molars and were at high risk for developing second molar periodontal defects after third molar extraction, that is mesioangular impaction and pre-existing periodontal defect (probing depth [PD] = or >5 mm) on the distal aspect of second molars. Within subjects, 1 postextraction site was randomly selected to receive scaling and root planing (SRP) of the distal surface of the second molar and the application of a polyglycolic acid/polylactic acid bioresorbable membrane (test site) and the opposite site served as control and was treated with SRP alone. The change in PD and clinical attachment level (CAL) as well as bone gain were assessed on the distal aspect of second molars over a 12-month period. RESULTS: Although both treatment modalities resulted in improvements in clinical parameters, the application of a bioresorbable membrane was statistical significantly more effective than SRP alone in reducing PD and in promoting CAL gain (P<0.0001). In 10 GTR-treated sites a complete bone fill was achieved, while 10 out of 11 control sites had residual intrabony defect. CONCLUSION: Subjects at high risk for developing second molar periodontal defects after third molar removal may benefit from the GTR-therapy at the time of surgical extraction of mesioangular impacted third molars to enhance periodontal healing. FAU - Aimetti, M AU - Aimetti M AD - Section of Periodontology, Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy. mario.aimetti@unito.it FAU - Romano, F AU - Romano F LA - eng PT - Controlled Clinical Trial PT - Journal Article PL - Italy TA - Minerva Stomatol JT - Minerva stomatologica JID - 0421071 RN - 0 (Biocompatible Materials) RN - 0 (Membranes, Artificial) SB - D SB - IM MH - Adult MH - *Biocompatible Materials MH - Female MH - *Guided Tissue Regeneration, Periodontal/methods MH - Humans MH - Male MH - Membranes, Artificial MH - Molar, Third/*surgery MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2007/12/20 09:00 MHDA- 2008/07/17 09:00 CRDT- 2007/12/20 09:00 PHST- 2007/12/20 09:00 [pubmed] PHST- 2008/07/17 09:00 [medline] PHST- 2007/12/20 09:00 [entrez] PST - ppublish SO - Minerva Stomatol. 2007 Oct;56(10):497-508. PMID- 18280963 OWN - NLM STAT- MEDLINE DCOM- 20080407 LR - 20151119 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 105 IP - 3 DP - 2008 Mar TI - The effect of a separate consultation on anxiety levels before third molar surgery. PG - 303-7 LID - 10.1016/j.tripleo.2007.07.028 [doi] AB - OBJECTIVES: The present study tested the effect of a separate consultation with an oral and maxillofacial surgeon on levels of anxiety before third molar extraction. STUDY DESIGN: Patients were randomly assigned to either the experimental or the control group. Experimental subjects received standard information about third molar extraction in a separate consultation visit before the surgical procedure. Control subjects received the same information just before and at the same visit as the surgical third molar removal. All patients completed several questionnaires covering measures of anxiety and pain. RESULTS: Having a separate consultation was highly appreciated by patients. However, no subsequent differences could be shown on the measures of anxiety. Strong associations between anxiety level and pain felt after the extraction were found. CONCLUSION: The practice of having a separate consultation (and possibly a more intensive one) should be considered by surgeons. FAU - van Wijk, Arjen AU - van Wijk A AD - Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands. a.vwijk@acta.nl FAU - Lindeboom, Jerome AU - Lindeboom J LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 SB - D SB - IM MH - Adult MH - Dental Anxiety/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Patient Satisfaction MH - *Preoperative Care MH - Statistics, Nonparametric MH - Surveys and Questionnaires MH - Tooth Extraction/*psychology EDAT- 2008/02/19 09:00 MHDA- 2008/04/09 09:00 CRDT- 2008/02/19 09:00 PHST- 2007/04/05 00:00 [received] PHST- 2007/07/12 00:00 [accepted] PHST- 2008/02/19 09:00 [pubmed] PHST- 2008/04/09 09:00 [medline] PHST- 2008/02/19 09:00 [entrez] AID - S1079-2104(07)00599-9 [pii] AID - 10.1016/j.tripleo.2007.07.028 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Mar;105(3):303-7. doi: 10.1016/j.tripleo.2007.07.028. PMID- 7042372 OWN - NLM STAT- MEDLINE DCOM- 19820719 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 21 IP - 5 DP - 1982 TI - Post-operative pain and inflammatory reaction reduced by injection of a corticosteroid. A controlled trial in bilateral oral surgery. PG - 391-6 AB - In a controlled crossover study, "identical" surgical procedures, the prophylactic removal of bilateral non-erupted 3rd molar teeth, were performed on two separate occasions in 24 healthy patients. Prior to each procedure, either betamethasone 9 mg (Celeston Chronodose) or placebo was administered intramuscularly, in a randomized fashion. Objective and subjective assessments were recorded for paired comparison of the post-operative course, including swelling, pain, trismus, local temperature, bleeding, wound-healing and preference for treatment. In 23 patients, less swelling occurred when betamethasone was given pre-operatively. The mean reduction on the 3rd and 6th post-operative days was 55% (p less than 0.001) and 69% (p less than 0.001), respectively. Pain assessments (visual analogue scale) were significantly lower after the corticosteroid injection; mean response: 1st evening 17 vs 56 mm, 2nd evening 5 vs 37 mm, and 3rd evening 2 vs 13 mm. No significant correlation between the steroid-induced reduction in swelling and pain could be made. This may indicate that dissociation may exist between pain and other inflammatory events like swelling. No clinically apparent infection or other disturbance of wound-healing was noted after corticosteroid administration. This treatment course was preferred by 23 of the 24 patients. FAU - Skjelbred, P AU - Skjelbred P FAU - Løkken, P AU - Løkken P LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 9842X06Q6M (Betamethasone) SB - IM MH - Adult MH - Betamethasone/*administration & dosage MH - Clinical Trials as Topic MH - Double-Blind Method MH - Female MH - Humans MH - Inflammation/*prevention & control MH - Injections, Intramuscular MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications/*prevention & control EDAT- 1982/01/01 00:00 MHDA- 1982/01/01 00:01 CRDT- 1982/01/01 00:00 PHST- 1982/01/01 00:00 [pubmed] PHST- 1982/01/01 00:01 [medline] PHST- 1982/01/01 00:00 [entrez] AID - 10.1007/BF00542325 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1982;21(5):391-6. doi: 10.1007/BF00542325. PMID- 16878063 OWN - NLM STAT- MEDLINE DCOM- 20061108 LR - 20131121 IS - 1698-6946 (Electronic) IS - 1698-4447 (Linking) VI - 11 IP - 5 DP - 2006 Aug 1 TI - The use of methylprednisolone versus diclofenac in the treatment of inflammation and trismus after surgical removal of lower third molars. PG - E440-5 AB - OBJECTIVE: To compare the efficacy of methylprednisolone (corticoid) versus diclofenac (nonsteroidal anti-inflammatory--NSAID) in the treatment of inflammation and trismus after the surgical removal of lower third molars. STUDY DESIGN: Prospective study on 73 patients for the surgical removal of their lower third molars. These patients were separated in two groups at random: the diclofenac group and the methylprednisolone group. A record card was filled in with preoperative and postoperative epidemiological and clinic data about inflammation and trismus (three facial measures and mouth opening). In order to make a broad study of data, BMDP program was used for statistics. RESULTS: 24 hours after surgery, patients in the diclofenac group showed a more severe inflammation in one of the facial measurements (<0.05). Trismus was very similar in both groups. CONCLUSIONS: There were no differences in trismus depending on the antiinflammatory used. Patients in the corticoid group showed less inflammation but the difference was not as important as to justify their use. FAU - López Carriches, Carmen AU - López Carriches C AD - Universidad Europea. carmen.lopez@uem.es FAU - Martínez González, José Ma AU - Martínez González JM FAU - Donado Rodríguez, Manuel AU - Donado Rodríguez M LA - eng LA - spa PT - Clinical Trial, Phase IV PT - Journal Article PT - Randomized Controlled Trial DEP - 20060801 PL - Spain TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Anti-Inflammatory Agents) RN - 144O8QL0L1 (Diclofenac) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Anti-Inflammatory Agents/*therapeutic use MH - Chi-Square Distribution MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Humans MH - Inflammation/prevention & control MH - Methylprednisolone/*therapeutic use MH - Molar, Third/surgery MH - Mouth Diseases/prevention & control MH - Prospective Studies MH - Statistics, Nonparametric MH - Tooth Extraction/*adverse effects MH - Trismus/etiology/*prevention & control EDAT- 2006/08/01 09:00 MHDA- 2006/11/10 09:00 CRDT- 2006/08/01 09:00 PHST- 2006/08/01 09:00 [pubmed] PHST- 2006/11/10 09:00 [medline] PHST- 2006/08/01 09:00 [entrez] AID - 10489405 [pii] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2006 Aug 1;11(5):E440-5. PMID- 8147520 OWN - NLM STAT- MEDLINE DCOM- 19940502 LR - 20190703 IS - 0003-2409 (Print) IS - 0003-2409 (Linking) VI - 49 IP - 3 DP - 1994 Mar TI - A comparison of patient and anaesthetist controlled midazolam sedation for dental surgery. PG - 241-4 AB - Thirty healthy Hong Kong Chinese patients between the ages of 15 and 31 years with bilaterally impacted lower third molar teeth, scheduled for surgical removal were studied. All the patients presented twice (for the right and left sides) and received, on separate occasions, patient or anaesthetist-controlled midazolam sedation allocated using a randomised, crossover design. Both techniques provided reliable sedation with verbal contact maintained, minimal changes in respiratory and cardiovascular function, good operating conditions and a high degree of patient satisfaction. The majority of patients (67%) thought they could sedate themselves better on a subsequent visit and were confident that they could do this more satisfactorily than the anaesthetist. An almost equal number preferred patient (n = 12) or anaesthetist (n = 13) controlled sedation, with the remainder having no preference. The total dose of midazolam was very similar in the two groups, 5.3 (SD 2.4) mg and 5.0 (SD 1.1) mg for patient and anaesthetist controlled sedation respectively. FAU - Rodrigo, M R AU - Rodrigo MR AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong. FAU - Tong, C K AU - Tong CK LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Anaesthesia JT - Anaesthesia JID - 0370524 RN - 0 (Hypnotics and Sedatives) RN - R60L0SM5BC (Midazolam) SB - AIM SB - IM MH - Adolescent MH - Adult MH - *Anesthesiology MH - Female MH - Humans MH - Hypnotics and Sedatives/*administration & dosage MH - Infusion Pumps MH - Male MH - Midazolam/*administration & dosage MH - Molar, Third/*surgery MH - Patient Satisfaction MH - Self Administration MH - Tooth, Impacted/*surgery EDAT- 1994/03/01 00:00 MHDA- 1994/03/01 00:01 CRDT- 1994/03/01 00:00 PHST- 1994/03/01 00:00 [pubmed] PHST- 1994/03/01 00:01 [medline] PHST- 1994/03/01 00:00 [entrez] AID - 10.1111/j.1365-2044.1994.tb03431.x [doi] PST - ppublish SO - Anaesthesia. 1994 Mar;49(3):241-4. doi: 10.1111/j.1365-2044.1994.tb03431.x. PMID- 22749707 OWN - NLM STAT- MEDLINE DCOM- 20140220 LR - 20130617 IS - 2212-4411 (Electronic) VI - 116 IP - 1 DP - 2013 Jul TI - Clinical study of hemodynamic changes comparing 4% articaine hydrochloride with 1:100,000 and 1:200,000 epinephrine. PG - e14-22 LID - S2212-4403(12)00177-0 [pii] LID - 10.1016/j.oooo.2011.10.043 [doi] AB - OBJECTIVE: To evaluate hemodynamic changes with the use of 4% articaine and 2 different concentrations of epinephrine (1:100,000 and 1:200,000) in the surgical removal of symmetrically positioned lower third molars. STUDY DESIGN: A prospective, randomized, double-blind clinical trial was carried out involving 42 patients each undergoing 2 surgeries on separate occasions under local anesthesia with 4% articaine and either epinephrine 1:100,000 or 1:200,000. The following parameters were assessed at 4 different moments: systolic, diastolic, and mean blood pressure; heart rate; oxygen saturation; rate pressure product (RPP); and pressure rate quotient (PRQ). RESULTS: The concentration of epinephrine did not affect diastolic blood pressure or oxygen saturation during the surgeries. Significant differences between were detected for heart rate, RPP, and PRQ (P < .05). CONCLUSIONS: The epinephrine concentration (1:100,000 or 1:200,000) in a 4% articaine solution influences hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar removal. CI - Copyright © 2013 Elsevier Inc. All rights reserved. FAU - de Morais, Hécio Henrique Araújo AU - de Morais HH AD - Faculdade de Odontologia de Pernambuco, University of Pernambuco, Pernambuco, Brazil. thiago.ctbmf@yahoo.com.br FAU - Holanda Vasconcellos, Ricardo José AU - Holanda Vasconcellos RJ FAU - de Santana Santos, Thiago AU - de Santana Santos T FAU - Rocha, Nelson Studart AU - Rocha NS FAU - da Costa Araújo, Fábio Andrey AU - da Costa Araújo FA FAU - de Carvalho, Ricardo Wathson Feitosa AU - de Carvalho RW LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20120629 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - D3SQ406G9X (Carticaine) RN - S88TT14065 (Oxygen) RN - YKH834O4BH (Epinephrine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/methods MH - Anesthetics, Local/*pharmacology MH - Blood Pressure MH - Carticaine/*pharmacology MH - Double-Blind Method MH - Epinephrine/*pharmacology MH - Female MH - Heart Rate MH - Hemodynamics/*drug effects MH - Humans MH - Male MH - Molar, Third/*surgery MH - Oxygen/blood MH - Prospective Studies MH - *Tooth Extraction MH - Vasoconstrictor Agents/*pharmacology EDAT- 2012/07/04 06:00 MHDA- 2014/02/22 06:00 CRDT- 2012/07/04 06:00 PHST- 2011/08/27 00:00 [received] PHST- 2011/10/20 00:00 [revised] PHST- 2011/10/31 00:00 [accepted] PHST- 2012/07/04 06:00 [entrez] PHST- 2012/07/04 06:00 [pubmed] PHST- 2014/02/22 06:00 [medline] AID - S2212-4403(12)00177-0 [pii] AID - 10.1016/j.oooo.2011.10.043 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jul;116(1):e14-22. doi: 10.1016/j.oooo.2011.10.043. Epub 2012 Jun 29. PMID- 16182911 OWN - NLM STAT- MEDLINE DCOM- 20051025 LR - 20111117 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 63 IP - 10 DP - 2005 Oct TI - Lingual nerve damage after mandibular third molar surgery: a randomized clinical trial. PG - 1443-6 AB - PURPOSE: The objective of this study was to clinically evaluate the frequency, type, and risk factors for lingual nerve damage after mandibular third molar surgery with reference to lingual flap retraction. PATIENTS AND METHODS: A total of fifty-five patients referred for bilateral mandibular third molar removal were included in this study. Each patient was randomly allotted to have the procedure performed on 1 side (experimental group) with lingual flap retraction. On the opposite side (control group), the same procedure was performed without lingual flap retraction. RESULTS: Lingual nerve damage occurred in 9.1% in the experimental group in which lingual flap retraction was performed. In the control group, damage to the lingual nerve was not observed. The difference was statistically significant (P <.001) as measured by the Cochran test. CONCLUSION: Lingual nerve retraction represented a risk factor to temporary lingual nerve damage during mandibular third molar surgery. FAU - Gomes, Ana Cláudia Amorim AU - Gomes AC AD - Department of Oral and Maxillofacial Surgery, University of Pernambuco, Camaragibe, Brazil. FAU - Vasconcelos, Belmiro Cavalcanti do Egito AU - Vasconcelos BC FAU - de Oliveira e Silva, Emanuel Dias AU - de Oliveira e Silva ED FAU - da Silva, Luiz Carlos Ferreira AU - da Silva LC LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM CIN - Evid Based Dent. 2006;7(2):47. PMID: 16858382 CIN - J Oral Maxillofac Surg. 2007 Feb;65(2):364. PMID: 17236957 MH - Adolescent MH - Adult MH - Cranial Nerve Injuries/*etiology MH - Humans MH - *Lingual Nerve Injuries MH - Mandible MH - Molar, Third/*surgery MH - Somatosensory Disorders/etiology MH - Tooth Extraction/*adverse effects/instrumentation/*methods MH - Tooth, Impacted/surgery EDAT- 2005/09/27 09:00 MHDA- 2005/10/26 09:00 CRDT- 2005/09/27 09:00 PHST- 2004/02/24 00:00 [received] PHST- 2005/06/05 00:00 [accepted] PHST- 2005/09/27 09:00 [pubmed] PHST- 2005/10/26 09:00 [medline] PHST- 2005/09/27 09:00 [entrez] AID - S0278-2391(05)01033-5 [pii] AID - 10.1016/j.joms.2005.06.012 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2005 Oct;63(10):1443-6. doi: 10.1016/j.joms.2005.06.012. PMID- 27475691 OWN - NLM STAT- MEDLINE DCOM- 20180416 LR - 20190609 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 21 IP - 5 DP - 2016 Sep 1 TI - Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. PG - e621-5 AB - BACKGROUND: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. MATERIAL AND METHODS: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). RESULTS: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p<0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p<0.05). CONCLUSIONS: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery. FAU - Todorovic, V-S AU - Todorovic VS AD - School of Dental Medicine, University of Belgrade, Serbia, todent@yahoo.com. FAU - Vasovic, M AU - Vasovic M FAU - Andric, M AU - Andric M FAU - Todorovic, L AU - Todorovic L FAU - Kokovic, V AU - Kokovic V LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160901 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Analgesics, Opioid) RN - UF599785JZ (Fentanyl) SB - D SB - IM MH - Analgesics, Opioid/*therapeutic use MH - Double-Blind Method MH - Fentanyl/*therapeutic use MH - Humans MH - Molar, Third/*surgery MH - Pain Management MH - Pain, Postoperative MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Transdermal Patch PMC - PMC5005101 COIS- The authors have declared that no conflict of interest exist. EDAT- 2016/08/01 06:00 MHDA- 2018/04/17 06:00 CRDT- 2016/08/01 06:00 PHST- 2015/11/19 00:00 [received] PHST- 2016/03/19 00:00 [accepted] PHST- 2016/08/01 06:00 [entrez] PHST- 2016/08/01 06:00 [pubmed] PHST- 2018/04/17 06:00 [medline] AID - 21161 [pii] AID - 10.4317/medoral.21161 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2016 Sep 1;21(5):e621-5. doi: 10.4317/medoral.21161. PMID- 1403273 OWN - NLM STAT- MEDLINE DCOM- 19921125 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 50 IP - 11 DP - 1992 Nov TI - Evaluation of dexamethasone for reduction of postsurgical sequelae of third molar removal. PG - 1177-82; discussion 1182-3 AB - Sixty patients with bilaterally symmetrical impacted third molars participated in this double-blind, within-subject study to quantify the effects of 4 mg of dexamethasone on reducing postsurgical sequelae. Each patient's surgery was staged by mouth side and completed in two appointments 5 to 6 weeks apart. A preoperative dose of dexamethasone given intravenously was randomized to mouth side and surgical appointment; sterile water served as a control. Major areas assessed in this study were facial swelling, pain, and trismus. No difference in swelling and daily pain was noted. However, trismus and global pain were significantly affected by the steroid. Patients had a daily postsurgical increase in incisal opening of 4 to 6 mm over the control side during the examination period. Patients evaluated pain by choosing the least painful side. By a greater than 4:1 margin, patients chose the steroid side as the least painful side. No increase in the rate or type of complications was detected between control and steroid sides. FAU - Neupert, E A 3rd AU - Neupert EA 3rd AD - Oral and Maxillofacial Surgery Department, Naval Hospital, Portsmouth, VA. FAU - Lee, J W AU - Lee JW FAU - Philput, C B AU - Philput CB FAU - Gordon, J R AU - Gordon JR LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 7S5I7G3JQL (Dexamethasone) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Dexamethasone/*administration & dosage MH - Edema/drug therapy MH - Humans MH - Injections, Intravenous MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/drug therapy MH - Postoperative Complications/*drug therapy MH - Tooth Extraction/*adverse effects MH - Trismus/drug therapy EDAT- 1992/11/01 00:00 MHDA- 1992/11/01 00:01 CRDT- 1992/11/01 00:00 PHST- 1992/11/01 00:00 [pubmed] PHST- 1992/11/01 00:01 [medline] PHST- 1992/11/01 00:00 [entrez] AID - 0278-2391(92)90149-T [pii] AID - 10.1016/0278-2391(92)90149-t [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1992 Nov;50(11):1177-82; discussion 1182-3. doi: 10.1016/0278-2391(92)90149-t. PMID- 9294499 OWN - NLM STAT- MEDLINE DCOM- 19971002 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 55 IP - 9 DP - 1997 Sep TI - Capnography and ventilatory assessment during ambulatory dentoalveolar surgery. PG - 921-5;discussion 925-6 AB - PURPOSE: The purpose of this study was to determine whether capnography is a more sensitive monitor than auscultation of breath sounds in detecting ventilatory changes consistent with hypoventilation, obstruction, or apnea and in detecting ventilatory changes that can be associated with oxygen desaturation. PATIENTS AND METHODS: Fifty-five patients received intravenous agents and supplemental oxygen to achieve a state of deep sedation or general anesthesia for removal of impacted third molars. The surgeon/anesthetist monitored respiratory status using a pretracheal stethoscope and direct observation. A blinded observer with no access to the patient or anesthetist monitored respiratory status using capnography. A second observer monitored all respiratory parameters to allow for correlation between clinical and electronic monitors. RESULTS: Ventilatory status was continuously represented by capnogaphy. The Pearson correlation coefficient showed a positive correlation between increased end-tidal CO2 (PETCO2) and decreased oxygen saturation that became stronger with greater positive changes in PETCO2. An additive relationship was found between PETCO2 and respiratory rate (RR), with increased PETCO2 and decreased RR contributing to decreased oxygen saturation. CONCLUSION: Patients with nasal ventilatory exchange maintain this exchange throughout the anesthesia so that sampling of nasal PETCO2 is an effective way to monitor ventilatory status. Respiratory depression or obstructive ventilatory changes detected by capnography showed a high sensitivity and low positive predictive value in detecting oxygen desaturation. The current technology does not show a clinically satisfactory correlation between PETCO2 and oxygen saturation. However, a combined increase in PETCO2 and decrease in RR suggested a trend of decreasing oxygen saturation. FAU - Bennett, J AU - Bennett J AD - Department of OMFS, University of Connecticut, School of Dental Medicine, Farmington 06030, USA. FAU - Peterson, T AU - Peterson T FAU - Burleson, J A AU - Burleson JA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolar Process/*surgery MH - *Ambulatory Surgical Procedures MH - Anesthesia, Dental MH - Auscultation/statistics & numerical data MH - *Capnography/statistics & numerical data MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Monitoring, Intraoperative/*methods/statistics & numerical data MH - Prospective Studies MH - Respiratory Sounds/*diagnosis MH - Sensitivity and Specificity MH - Tooth, Impacted/surgery EDAT- 1997/09/19 00:00 MHDA- 1997/09/19 00:01 CRDT- 1997/09/19 00:00 PHST- 1997/09/19 00:00 [pubmed] PHST- 1997/09/19 00:01 [medline] PHST- 1997/09/19 00:00 [entrez] AID - S0278239197001195 [pii] AID - 10.1016/s0278-2391(97)90058-6 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1997 Sep;55(9):921-5;discussion 925-6. doi: 10.1016/s0278-2391(97)90058-6. PMID- 21636189 OWN - NLM STAT- MEDLINE DCOM- 20120925 LR - 20140113 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 50 IP - 3 DP - 2012 Apr TI - The effect of sutureless wound closure on postoperative pain and swelling after impacted mandibular third molar surgery. PG - 256-8 LID - 10.1016/j.bjoms.2011.04.075 [doi] AB - Our aim was to assess the influence of sutureless and multiple-suture closure of wounds on postoperative complications after extraction of bilateral, impacted, mandibular third molars in 30 patients in a split mouth study. After the teeth had been removed, on one side the flap was replaced but with no suture to hold it in place (study side), and on the other side the wound was closed primarily with three sutures (control side). Recorded complications included pain, swelling, bleeding, and formation of periodontal pockets. The results showed that patients had significantly less postoperative pain and swelling when no sutures were used (p=0.005). There were no signs of excessive bleeding or oozing postoperatively on either side. Six months postoperatively there was no significant difference in the depth of the periodontal pocket around the second molar. CI - Copyright © 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Hashemi, Hamid Mahmood AU - Hashemi HM AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. hamid5212@yahoo.com FAU - Beshkar, Majid AU - Beshkar M FAU - Aghajani, Reihaneh AU - Aghajani R LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110601 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 2013 Dec;51(8):e321. PMID: 23351388 MH - Edema/*etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*etiology MH - Periodontal Pocket/etiology MH - *Postoperative Complications MH - Postoperative Hemorrhage/etiology MH - Surgical Flaps MH - Suture Techniques MH - Tooth Extraction/methods MH - Tooth, Impacted/*surgery MH - Wound Closure Techniques MH - Wound Healing/physiology MH - Young Adult EDAT- 2011/06/04 06:00 MHDA- 2012/09/26 06:00 CRDT- 2011/06/04 06:00 PHST- 2011/01/11 00:00 [received] PHST- 2011/04/28 00:00 [accepted] PHST- 2011/06/04 06:00 [entrez] PHST- 2011/06/04 06:00 [pubmed] PHST- 2012/09/26 06:00 [medline] AID - S0266-4356(11)00428-1 [pii] AID - 10.1016/j.bjoms.2011.04.075 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2012 Apr;50(3):256-8. doi: 10.1016/j.bjoms.2011.04.075. Epub 2011 Jun 1. PMID- 21802822 OWN - NLM STAT- MEDLINE DCOM- 20111229 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 11 DP - 2011 Nov TI - Prophylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: a split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg). PG - e333-9 LID - 10.1016/j.joms.2011.03.055 [doi] FAU - Bezerra, Tácio Pinheiro AU - Bezerra TP AD - Department of Oral and Maxillofacial Surgery, Post-Graduation Program in Dentistry of the Federal University of Ceará, Ceará, Brazil. taciopb@uol.com.br FAU - Studart-Soares, Eduardo Costa AU - Studart-Soares EC FAU - Scaparo, Henrique Clasen AU - Scaparo HC FAU - Pita-Neto, Ivo Cavalcante AU - Pita-Neto IC FAU - Batista, Saulo Hilton Botelho AU - Batista SH FAU - Fonteles, Cristiane Sá Roriz AU - Fonteles CS LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110729 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Placebos) RN - 804826J2HU (Amoxicillin) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Amoxicillin/*therapeutic use MH - *Antibiotic Prophylaxis MH - Double-Blind Method MH - Dry Socket/prevention & control MH - Edema/*prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Molar, Third/*surgery MH - Oral Ulcer/prevention & control MH - Osteotomy/methods MH - Pain Measurement MH - Placebos MH - Postoperative Complications/*prevention & control MH - Range of Motion, Articular/physiology MH - Suppuration MH - Surgical Wound Infection/*prevention & control MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Young Adult EDAT- 2011/08/02 06:00 MHDA- 2011/12/30 06:00 CRDT- 2011/08/02 06:00 PHST- 2010/10/28 00:00 [received] PHST- 2011/03/22 00:00 [revised] PHST- 2011/03/28 00:00 [accepted] PHST- 2011/08/02 06:00 [entrez] PHST- 2011/08/02 06:00 [pubmed] PHST- 2011/12/30 06:00 [medline] AID - S0278-2391(11)00594-5 [pii] AID - 10.1016/j.joms.2011.03.055 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Nov;69(11):e333-9. doi: 10.1016/j.joms.2011.03.055. Epub 2011 Jul 29. PMID- 2700702 OWN - NLM STAT- MEDLINE DCOM- 19900813 LR - 20071115 IS - 0012-1029 (Print) IS - 0012-1029 (Linking) VI - 44 IP - 11 DP - 1989 Nov TI - [Antiphlogistic effect of bromelaine following third molar removal]. PG - 830-2 AB - A placebo-controlled double-blind study of 100 patients with impacted and/or dislocated lower wisdom teeth was conducted to examine the tolerance and antiphlogistic efficacy of bromelaine--a mixture of proteolytic enzymes from ananas comosus. Treatment was started 1 day prior to third molar surgery with a daily dose of 3 x 80 mg and was continued for a total of 6 days. On the 1st day following surgery, linear measurement (distance: tragus-pogonion) showed swelling to be 7.5% lower under drug treatment than in the placebo group. Two-dimensional image evaluation increased this difference to 15.9%, which however still failed to attain the significance level of 20%. Between the 3rd and the 7th postoperative day no differences were found between the two groups regarding the extent of soft tissue swelling or the speed of edema resolution. FAU - Hotz, G AU - Hotz G FAU - Frank, T AU - Frank T FAU - Zöller, J AU - Zöller J FAU - Wiebelt, H AU - Wiebelt H LA - ger PT - Clinical Trial PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Zur antiödematösen Wirksamkeit von Bromelain nach operativer Weisheitszahnentfernung. PL - Germany TA - Dtsch Zahnarztl Z JT - Deutsche zahnarztliche Zeitschrift JID - 2984745R RN - 9001-00-7 (Bromelains) SB - D MH - Adolescent MH - Adult MH - Analysis of Variance MH - Bromelains/*therapeutic use MH - Double-Blind Method MH - Edema/*prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Premedication MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1989/11/01 00:00 MHDA- 1989/11/01 00:01 CRDT- 1989/11/01 00:00 PHST- 1989/11/01 00:00 [pubmed] PHST- 1989/11/01 00:01 [medline] PHST- 1989/11/01 00:00 [entrez] PST - ppublish SO - Dtsch Zahnarztl Z. 1989 Nov;44(11):830-2. PMID- 8818259 OWN - NLM STAT- MEDLINE DCOM- 19961205 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 34 IP - 3 DP - 1996 Jun TI - Bilateral block: is it safe and more efficient during removal of third molars? PG - 243-7 AB - OBJECTIVE- to assess the safety, acceptability, and efficacy of removing bilaterally impacted wisdom teeth as a one-stage rather than a two-stage procedure. DESIGN- randomised controlled trial. Setting - district hospital. SUBJECTS- 100 consecutive patients who required removal of bilaterally impacted third molars. INTERVENTIONS- 50 patients were randomised to have the teeth removed in two stages, 3-4 weeks apart, the other 50 to have the teeth removed at one visit. All operations were done under local anaesthetic (2% lignocaine and 1/80 000 adrenaline) and intravenous midazolam 0.07-0.13 mg/kg titrated against sedative effect individually. Main outcome measures - morbidity, time off work, anxiety scores (assessed by visual analogue scale), and patient opinions. RESULTS- 5 patients were withdrawn because they were not given the randomised treatment, and 10 were lost to follow-up, leaving 40 in the two-stage group and 45 in the one-stage group for analysis. Two patients in the one stage group developed SaO2 of less than 90% which was corrected by deep breathing, and another had a temporary parasthesia of the inferior alveolar nerve that resolved within a week. One patient in the two stage group had a haemorrhage after the first stage that required packing of the socket in the emergency department, and this patient refused to have the second tooth removed. The mean number of days taken off work was significantly less in the one stage group (mean 3 days compared with 5 days (P < 0.005), and the anxiety scores did not differ significantly between the two groups. A quarter of the patients in the two-stage group would have preferred a one-stage procedure, but none in the one-stage group would have preferred a two-stage operation. CONCLUSIONS- removal of bilaterally impacted wisdom teeth under local anaesthesia and sedation in one session is safe, cost effective and acceptable to patients. FAU - Holland, I S AU - Holland IS AD - Department of Oral and Facial Surgery, Sunderland District General Hospital, UK. FAU - Stassen, L F AU - Stassen LF LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anesthetics, Local) RN - 0 (Hypnotics and Sedatives) RN - 98PI200987 (Lidocaine) RN - R60L0SM5BC (Midazolam) RN - S88TT14065 (Oxygen) RN - YKH834O4BH (Epinephrine) SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 1997 Feb;35(1):74. PMID: 9043014 CIN - Br J Oral Maxillofac Surg. 1997 Aug;35(4):299. PMID: 9291276 MH - Absenteeism MH - *Anesthesia, Dental/adverse effects MH - Anesthesia, Local MH - Anesthetics, Local/administration & dosage MH - Anxiety/etiology MH - Conscious Sedation MH - Epinephrine MH - Female MH - Follow-Up Studies MH - Humans MH - Hypnotics and Sedatives/administration & dosage MH - Lidocaine/administration & dosage MH - Male MH - Mandibular Nerve/drug effects MH - Midazolam/administration & dosage MH - Molar, Third/*surgery MH - *Nerve Block/adverse effects MH - Oxygen/blood MH - Paresthesia/etiology MH - Patient Satisfaction MH - Postoperative Hemorrhage/etiology MH - Safety MH - *Tooth Extraction/adverse effects/methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 1996/06/01 00:00 MHDA- 1996/06/01 00:01 CRDT- 1996/06/01 00:00 PHST- 1996/06/01 00:00 [pubmed] PHST- 1996/06/01 00:01 [medline] PHST- 1996/06/01 00:00 [entrez] AID - 10.1016/s0266-4356(96)90278-8 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1996 Jun;34(3):243-7. doi: 10.1016/s0266-4356(96)90278-8. PMID- 8530996 OWN - NLM STAT- MEDLINE DCOM- 19960201 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 54 IP - 1 DP - 1996 Jan TI - Oral surgery in anticoagulated patients without reducing the dose of oral anticoagulant: a prospective randomized study. PG - 27-32; discussion 323 AB - PURPOSE: This study assessed the risk associated with several schedules of perioperative treatment with coumadin in anticoagulated patients who underwent oral surgery. PATIENTS AND METHODS: A prospective, randomized study compared bleeding complications with six perioperative schedules in 92 patients chronically treated with acenocoumarol. In three of the perioperative schedules, the dose was reduced before surgery and calcium heparin was added. In the other three, oral anticoagulation was not modified and heparin was not used. The groups also differed regarding the antifibrinolytic agents used and the postoperative measures applied. RESULTS: Those schedules in which the oral anticoagulation was not modified preoperatively and an antifibrinolytic agent was applied locally both during and after surgery were not associated with a significantly higher odds ratio of bleeding complications than those in whom oral anticoagulation was reduced and calcium heparin was added preoperatively. CONCLUSIONS: In orally anticoagulated patients who undergo oral surgery, schedules that maintain the oral anticoagulant regimen and use local tranexamic acid as an antifibrinolytic agent postoperatively for 2 days are safe, simple, and less troublesome. FAU - Souto, J C AU - Souto JC AD - Unitat d'Hemostasia i Trombosi, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. FAU - Oliver, A AU - Oliver A FAU - Zuazu-Jausoro, I AU - Zuazu-Jausoro I FAU - Vives, A AU - Vives A FAU - Fontcuberta, J AU - Fontcuberta J LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anticoagulants) RN - 0 (Antifibrinolytic Agents) RN - 0 (Mouthwashes) RN - 6T84R30KC1 (Tranexamic Acid) RN - 9005-49-6 (Heparin) RN - I6WP63U32H (Acenocoumarol) SB - AIM SB - D SB - IM CIN - J Oral Maxillofac Surg. 1996 May;54(5):657. PMID: 8632257 CIN - Br J Oral Maxillofac Surg. 2002 Jun;40(3):266. PMID: 12054729 MH - Acenocoumarol/administration & dosage MH - Administration, Oral MH - Anticoagulants/*administration & dosage MH - Antifibrinolytic Agents/administration & dosage MH - Chi-Square Distribution MH - Dental Care for Chronically Ill/*methods MH - Female MH - Heart Valve Diseases MH - Heart Valve Prosthesis MH - Heparin/administration & dosage MH - Humans MH - Logistic Models MH - Male MH - Mouthwashes/therapeutic use MH - Odds Ratio MH - Prospective Studies MH - Thromboembolism/*prevention & control MH - *Tooth Extraction MH - Tranexamic Acid/administration & dosage EDAT- 1996/01/01 00:00 MHDA- 1996/01/01 00:01 CRDT- 1996/01/01 00:00 PHST- 1996/01/01 00:00 [pubmed] PHST- 1996/01/01 00:01 [medline] PHST- 1996/01/01 00:00 [entrez] AID - S0278-2391(96)90297-9 [pii] AID - 10.1016/s0278-2391(96)90297-9 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1996 Jan;54(1):27-32; discussion 323. doi: 10.1016/s0278-2391(96)90297-9. PMID- 120339 OWN - NLM STAT- MEDLINE DCOM- 19800627 LR - 20191027 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 8 IP - 6 DP - 1979 Dec TI - Tranexamic acid in alveolar sockets in the prevention of alveolitis sicca dolorosa. PG - 421-9 AB - The effect of trans-4-amino-methyl-cyclohexane acid (AMCA) and a placebo preparation on the development of alveolitis sicca dolorosa (ASD) was investigated in a double-blind designed experiment. The preoperative registrations were age, sex, use of oral contraceptives, menstrual cycle, smoking, degree of impaction and operation time. The study included 120 healthy persons. Each person had bilateral impacted mandibular molars removed surgically at one session. AMCA (160 mg/extraction site) or placebor was applied in each socket after the operation. The postoperative course was evaluated on average 5 days later by the use of 13 different variables describing local and general discomfort. The incidence of ASD was 7.5% in the AMCA side and 5.0% in the placebo side. The result shows that a local inhibition of plasminogen activation by AMCA is insufficient to prevent the development of ASD. The occurrence of ASD and postoperative discomfort was not increased in women operated during the menstrual period. The usage of oral contraceptives is known to be associated with a high frequency of ASD. Women taking oral contraceptives may therefore postpone the operation to the withdrawal period of the pill, to reduce the risk of developing ASD. Postoperative pains and the consumption of analgetics were significantly increased in patients who were habitual smokers. FAU - Gersel-Pedersen, N AU - Gersel-Pedersen N LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Contraceptives, Oral) RN - 0 (Cyclohexanecarboxylic Acids) RN - 0 (Placebos) RN - 0 (Tablets) RN - 6T84R30KC1 (Tranexamic Acid) SB - D SB - IM SB - J MH - Adolescent MH - Adult MH - Age Factors MH - Alveolar Process MH - Contraceptives, Oral/adverse effects MH - Cyclohexanecarboxylic Acids/*therapeutic use MH - Double-Blind Method MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Postoperative Complications MH - Smoking/complications MH - Tablets MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Tranexamic Acid/*therapeutic use OID - PIP: 798864 OID - POP: 00080544 OAB - This double-blind study designed to assess the effect of trans-r-amino-methyl-cyclohexane acid (AMCA) vs. placebo on development of alveolitis sicca dolorosa (ASD) had as preoperative registration requirements age, sex, use of oral contraceptives, menstrual cycle, smoking, and degree of impaction at time of operation. Following operation for impacted molars, AMCA or placebo was applied, and 5 days later the postoperative course was evaluated. Overall, AMCA did not have enough local inhibition of plasminogen activation to prevent development of ASD, since incidence of ASD was 7.5% in the treated side and 5% in the placebo side. Menstrual period did not augment postoperative discomfort. Oral contraceptive use, however, gave a much higher risk of developing ASD, and it is recommended that women withdraw from oral contraception before oral surgery. Smoking increased postoperative pain. OABL- eng OTO - PIP OT - *Age Factors OT - Behavior OT - Contraception OT - Contraceptive Methods--side effects OT - Demographic Factors OT - *Double-blind Studies OT - Family Planning OT - *Menstrual Cycle OT - Menstruation OT - *Oral Contraceptives--side effects OT - Population OT - Population Characteristics OT - Reproduction OT - Research Methodology OT - *Smoking--side effects OT - Studies GN - PIP: TJ: INTERNATIONAL JOURNAL OF ORAL SURGERY. EDAT- 1979/12/01 00:00 MHDA- 1979/12/01 00:01 CRDT- 1979/12/01 00:00 PHST- 1979/12/01 00:00 [pubmed] PHST- 1979/12/01 00:01 [medline] PHST- 1979/12/01 00:00 [entrez] AID - 10.1016/s0300-9785(79)80080-0 [doi] PST - ppublish SO - Int J Oral Surg. 1979 Dec;8(6):421-9. doi: 10.1016/s0300-9785(79)80080-0. PMID- 24171980 OWN - NLM STAT- MEDLINE DCOM- 20141010 LR - 20191027 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 14 IP - 3 DP - 2013 May 1 TI - Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study. PG - 401-4 AB - AIM: To evaluate the relative ability of 4 mg dose of intraoperative dexamethasone, administered submucosally, to reduce the postoperative discomfort after third molar surgery. MATERIALS AND METHODS: A total of 100 patients requiring surgical removal of a single mandibular third molar were included. The experimental group (50) received dexamethasone 4 mg as submucosal injection and control group (50) received no drugs. The maximum interincisal distance and facial contours were measured at baseline and at postsurgery days 2 and 7. The measurement of pain was done using visual analog scale (VAS). RESULTS: None of the patients developed wound infection or any serious postoperative complications. Postoperative edema tended to be less severe on the second postoperative day in the experimental group and the result was statistically significant. There were no significant differences in the reduction of pain and trismus between the two groups studied. CONCLUSION: Submucosal administration of dexamethasone sodium phosphate (4 mg) results in reduction of postoperative edema, comparable with or greater than other routes of administration. Presumably, a higher effective drug concentration at the site of injury without loss due to distribution to other compartments may be achieved, and the submucosal route is convenient for both the surgeon and the patient. CLINICAL SIGNIFICANCE: Submucosal route of administration of dexamethasone (4 mg) is effective in reducing postoperative discomfort after third molar surgeries. FAU - Nair, Rakesh B AU - Nair RB AD - Senior Lecturer, Department of Maxillofacial Surgery, MES Dental College, Perinthalmanna, Malappuram, Kerala, India, e-mail: drrakesh83@yahoo.co.in. FAU - Rahman, N M Mujeeb AU - Rahman NM FAU - Ummar, M AU - Ummar M FAU - Hafiz, K A Abdul AU - Hafiz KA FAU - Issac, Johnson K AU - Issac JK FAU - Sameer, K M AU - Sameer KM LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130501 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Administration, Buccal MH - Administration, Mucosal MH - Anti-Inflammatory Agents/*administration & dosage MH - Dexamethasone/*administration & dosage MH - Edema/prevention & control MH - Follow-Up Studies MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement/methods MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications/prevention & control MH - Premedication MH - Prospective Studies MH - Range of Motion, Articular/physiology MH - Tooth Extraction/*methods MH - Trismus/prevention & control MH - Visual Analog Scale EDAT- 2013/11/01 06:00 MHDA- 2014/10/11 06:00 CRDT- 2013/11/01 06:00 PHST- 2013/11/01 06:00 [entrez] PHST- 2013/11/01 06:00 [pubmed] PHST- 2014/10/11 06:00 [medline] AID - 1526-3711-1077 [pii] AID - 10.5005/jp-journals-10024-1335 [doi] PST - epublish SO - J Contemp Dent Pract. 2013 May 1;14(3):401-4. doi: 10.5005/jp-journals-10024-1335. PMID- 11286448 OWN - NLM STAT- MEDLINE DCOM- 20010712 LR - 20181130 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 39 IP - 2 DP - 2001 Apr TI - Role of antimicrobials in third molar surgery: prospective, double blind,randomized, placebo-controlled clinical study. PG - 134-7 AB - AIM: To test the efficacy of two dosing regimens of antimicrobial prophylaxis during the removal of impacted lower third molars. DESIGN: Double blind, prospective, placebo-controlled trial. SETTING: Teaching hospital, India. SUBJECTS: 151 patients aged 19-36 having impacted lower third molars removed. METHODS: Random allocation into three groups: placebo (n= 34), metronidazole 1g orally, 1 hour preoperatively (n= 44), or metronidazole 400mg orally eight hourly for 5 days postoperatively (n= 47). Patients were recalled on the sixth postoperative day for assessment of pain scores on the second and sixth days, swelling, differences in mouth opening between preoperative and the sixth postoperative day, and the state of the wound. RESULTS: There were no significant differences in the outcome between the three groups (P= 0.09). CONCLUSION: Antimicrobial prophylaxis does not seem to reduce morbidity after removal of lower third molars. CI - Copyright 2001 The British Association of Oral and Maxillofacial Surgeons. FAU - Sekhar, C H AU - Sekhar CH AD - Postgraduate Resident; Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Madras, India FAU - Narayanan, V AU - Narayanan V FAU - Baig, M F AU - Baig MF LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anti-Infective Agents) RN - 140QMO216E (Metronidazole) SB - D SB - IM MH - Adult MH - Analysis of Variance MH - Anti-Infective Agents/administration & dosage MH - Antibiotic Prophylaxis/*statistics & numerical data MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Metronidazole/administration & dosage MH - Molar, Third/*surgery MH - Prospective Studies MH - *Tooth Extraction EDAT- 2001/04/05 10:00 MHDA- 2001/07/19 10:01 CRDT- 2001/04/05 10:00 PHST- 2001/04/05 10:00 [pubmed] PHST- 2001/07/19 10:01 [medline] PHST- 2001/04/05 10:00 [entrez] AID - S0266-4356(00)90557-6 [pii] AID - 10.1054/bjom.2000.0557 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2001 Apr;39(2):134-7. doi: 10.1054/bjom.2000.0557. PMID- 15853098 OWN - NLM STAT- MEDLINE DCOM- 20050519 LR - 20151119 IS - 0361-7734 (Print) IS - 0361-7734 (Linking) VI - 30 IP - 2 DP - 2005 Mar-Apr TI - Response of human pulp capped with a bonding agent after bleeding control with hemostatic agents. PG - 147-55 AB - PURPOSE: This study evaluated the response of human pulps capped with a bonding agent after bleeding control with different hemostatic agents. MATERIAL AND METHODS: Twenty-five Class II cavities were prepared in 25 caries-free human premolars scheduled for extraction due to orthodontic treatment. The pulp exposures were performed on the occlusal floor. The teeth were randomly divided into five groups. Groups 1-4 were capped with an adhesive system after hemostasis with different agents: Group 1--saline solution; 2--ferric sulfate; 3--2.5% NaOCl; 4--Ca(OH)2 solution. In Group 5, after hemostasis with saline solution, the pulp was capped with calcium hydroxide (control group). Then, ScotchBond Multi Purpose Plus was applied and the resin composite Z-100 placed incrementally according to the manufacturers' directions. After 60 days, the teeth were extracted and processed for light microscopic examination (HE) and the groups were categorized in a histological score system. The data were subjected to a non-parametric test (alpha=0.05). RESULTS: Overall, the histological features showed that the pulp response from Groups 1 through 4 was inferior to the response from Group 5, where dentin bridging occurred. In all groups, where the adhesive system was used for capping, the pulp response varied from an acute inflammatory, with varying degrees, to necrosis. No dentin bridge was formed after adhesive capping. FAU - Accorinte, Maria de Lourdes Rodrigues AU - Accorinte Mde L AD - Department of Dental Materials, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil. FAU - Loguercio, Alessandro Dourado AU - Loguercio AD FAU - Reis, Alessandra AU - Reis A FAU - Muench, Antonio AU - Muench A FAU - de Araújo, Vera Cavalcanti AU - de Araújo VC LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oper Dent JT - Operative dentistry JID - 7605679 RN - 0 (Astringents) RN - 0 (Composite Resins) RN - 0 (Dentin-Bonding Agents) RN - 0 (Ferric Compounds) RN - 0 (Hemostatics) RN - 0 (Resin Cements) RN - 0 (Scotchbond Multi-Purpose) RN - 0 (Z100 composite resin) RN - 3HWS7HF5XD (ferric sulfate) RN - 451W47IQ8X (Sodium Chloride) RN - 7631-86-9 (Silicon Dioxide) RN - C6V6S92N3C (Zirconium) RN - DY38VHM5OD (Sodium Hypochlorite) RN - PF5DZW74VN (Calcium Hydroxide) SB - D MH - Adolescent MH - Adult MH - Astringents/therapeutic use MH - Bicuspid MH - Calcium Hydroxide/therapeutic use MH - Composite Resins/chemistry MH - Dental Cavity Preparation/classification MH - Dental Pulp/*drug effects/pathology MH - Dental Pulp Capping/*methods MH - Dental Pulp Necrosis/pathology MH - Dental Restoration, Permanent MH - Dentin, Secondary/drug effects/pathology MH - Dentin-Bonding Agents/*chemistry MH - Ferric Compounds/therapeutic use MH - Hemostatics/*therapeutic use MH - Humans MH - Pulpitis/pathology MH - Resin Cements/chemistry MH - Silicon Dioxide/chemistry MH - Sodium Chloride MH - Sodium Hypochlorite/therapeutic use MH - Wound Healing/drug effects MH - Zirconium/chemistry EDAT- 2005/04/28 09:00 MHDA- 2005/05/20 09:00 CRDT- 2005/04/28 09:00 PHST- 2005/04/28 09:00 [pubmed] PHST- 2005/05/20 09:00 [medline] PHST- 2005/04/28 09:00 [entrez] PST - ppublish SO - Oper Dent. 2005 Mar-Apr;30(2):147-55. PMID- 786680 OWN - NLM STAT- MEDLINE DCOM- 19761201 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 8 IP - 3-4 DP - 1975 Apr 4 TI - Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen. PG - 209-16 AB - It was considered that double-blind crossover studies of therapeutic efficacy after acute injury could well be done in patients who required surgical removal of impacted wisdom teeth from both sides of the lower jaw. In the present trial 24 healthy patients received either placebo or ibuprofen (Brufen: 400 mg three times daily), a non-steroidal anti-inflammatory agent, for 5 days commencing the day before surgery. Treatments were given on the two occasions when impacted wisdom teeth were to be removed from one side or other of the lower jaw. A number of objective and subjective parameters were recorded for paired comparison of the post-operative courses, including swelling, trismus and pain. A mechanical device which allows simple and accurate measurement of cheek swelling is described. On the 1st, 3rd and 5th post-operative days in the ibuprofen group the measured swelling averaged 93, 89 and 82%, respectively, of that in the placebo group; the corresponding alpha-values were 0.35, 0.06 and 0.07. Patients with less swelling after ibuprofen were not always those with a high serum concentration of the drug. Ibuprofen significantly reduced pain on the day of the operation. This may at least partly account for less trismus and the preference of the patients for their post-operative courses with ibuprofen. Examination of various haematological parameters did not reveal any significant difference between the two operations. Subjective scores indicated that neither wound-healing nor bleeding was affected by ibuprofen, nor were any side effects detected. FAU - Lökken, P AU - Lökken P FAU - Olsen, I AU - Olsen I FAU - Bruaset, I AU - Bruaset I FAU - Norman-Pedersen, K AU - Norman-Pedersen K LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Phenylpropionates) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Adolescent MH - Adult MH - Clinical Trials as Topic MH - Drug Evaluation MH - Edema MH - Female MH - Hemostasis/drug effects MH - Humans MH - Ibuprofen/adverse effects/blood/*therapeutic use MH - Inflammation/*drug therapy MH - Male MH - Mandible/surgery MH - *Molar/surgery MH - Pain, Postoperative/drug therapy MH - Phenylpropionates/*therapeutic use MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus EDAT- 1975/04/04 00:00 MHDA- 1975/04/04 00:01 CRDT- 1975/04/04 00:00 PHST- 1975/04/04 00:00 [pubmed] PHST- 1975/04/04 00:01 [medline] PHST- 1975/04/04 00:00 [entrez] AID - 10.1007/BF00567117 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):209-16. doi: 10.1007/BF00567117. PMID- 12686924 OWN - NLM STAT- MEDLINE DCOM- 20030717 LR - 20061115 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 95 IP - 4 DP - 2003 Apr TI - Marginal flap versus paramarginal flap in impacted third molar surgery: a prospective study. PG - 403-8 AB - OBJECTIVE: A clinical prospective study was carried out to compare 2 flap designs-marginal and paramarginal-that are used during impacted third molar surgery. MATERIALS AND METHODS: Twenty-seven healthy patients (ages 17 to 31 years) who underwent surgical removal of 4 impacted third molars, including 54 lower and 54 upper, were included. A marginal flap was used in 1 randomly chosen half of the jaw, and a paramarginal flap was used in the other half. The influence of these flaps on wound healing, periodontal pocket depth of the adjacent second molar, pain, trismus, and swelling was studied. RESULTS: Wound dehiscences developed in 8 paramarginal flap cases, whereas none occurred with the use of a marginal flap. The buccal and distal probing depths of the adjacent second molar were significantly bigger in marginal flaps at 5 and 10 days after surgery. However, the probing depth was similar with the use of both techniques at 3 months. Pain, trismus, and swelling were similar with both techniques. CONCLUSIONS: We found no advantages to the use of a paramarginal flap instead of a traditional marginal flap for removing impacted third molars. FAU - Suarez-Cunqueiro, Maria Mercedes AU - Suarez-Cunqueiro MM AD - Department of Oral and Craniomaxillofacial Surgery, University Hospital Freiburg, Albert-Ludwigs-University, Germany. FAU - Gutwald, Ralf AU - Gutwald R FAU - Reichman, Jan AU - Reichman J FAU - Otero-Cepeda, Xose Luis AU - Otero-Cepeda XL FAU - Schmelzeisen, Rainer AU - Schmelzeisen R LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Chi-Square Distribution MH - Edema/etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Molar/pathology MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology MH - Periodontal Pocket/pathology MH - Postoperative Complications MH - Prospective Studies MH - Surgical Flaps/*classification MH - Surgical Wound Dehiscence/etiology MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus/etiology MH - Wound Healing EDAT- 2003/04/11 05:00 MHDA- 2003/07/18 05:00 CRDT- 2003/04/11 05:00 PHST- 2003/04/11 05:00 [pubmed] PHST- 2003/07/18 05:00 [medline] PHST- 2003/04/11 05:00 [entrez] AID - S1079210402916859 [pii] AID - 10.1067/moe.2003.84 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Apr;95(4):403-8. doi: 10.1067/moe.2003.84. PMID- 26968285 OWN - NLM STAT- MEDLINE DCOM- 20170113 LR - 20170113 IS - 0030-9982 (Print) IS - 0030-9982 (Linking) VI - 66 IP - 3 DP - 2016 Mar TI - Efficacy of immediate postoperative intramasseteric dexamethasone injection on postoperative swelling after mandibular impacted third molar surgery: A preliminary split-mouth study. PG - 320-3 AB - OBJECTIVE: To evaluate the efficacy of immediate intramasseteric injection of dexamethasone on postoperative oedema. METHODS: The prospective study was conducted at the Department of Oral and Maxillofacial Surgery, Ankara University, Ankara, Turkey, in July 2012, and comprised patients aged 15-32 years who presented for the removal of bilateral vertical impacted mandibular third molar teeth.The right and left impacted third molars of each patient were randomly allocated into study and control groups. The impacted teeth in the study group were extracted with surgical bone removal, and 2ml of 8mg/2ml dexamethasone was injected into the ipsilateral masseter muscle immediately after suturing.In the control group, dexamethasone was replaced with 2ml of sterile saline solution. Postoperative facial oedema was measured with a tape scale by calculating the distance between several facial landmarks on postoperative day 2. SPSS 15 was used for data analysis. RESULTS: The mean age of 20 patients was 21.35±4.18 years, and there were 9(45%) patients between 15-20 years of age, while 11(55%) were 21-32 years. IN terms of gender, 9(45%) patients were male and 11(55%) were female. Postoperative oedema was significantly reduced in the study group compared to the control group (p<0.05). CONCLUSIONS: Immediate intramasseteric injection of dexamethasone was effective in reducing postoperative oedema after mandibular impacted third molar surgery. FAU - Dereci, Omur AU - Dereci O AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Eskisehir Osmangazi University, Eskisehir, Turkey. FAU - Tuzuner-Oncul, Aysegul Mine AU - Tuzuner-Oncul AM AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara University, Ankara, Turkey. FAU - Kocer, Gulperi AU - Kocer G AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Suleyman Demirel University, Isparta, Turkey. FAU - Yuce, Esra AU - Yuce E AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Suleyman Demirel University, Isparta, Turkey. FAU - Askar, Mehmet AU - Askar M AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara University, Ankara, Turkey. FAU - Ozturk, Adnan AU - Ozturk A AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara University, Ankara, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Pakistan TA - J Pak Med Assoc JT - JPMA. The Journal of the Pakistan Medical Association JID - 7501162 RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) SB - IM MH - Adolescent MH - Adult MH - Dexamethasone/*therapeutic use MH - Edema/*prevention & control MH - Female MH - Glucocorticoids/*therapeutic use MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible/*surgery MH - *Masseter Muscle MH - Molar, Third/*surgery MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Young Adult OTO - NOTNLM OT - Dexamethasone, Oedema, Third molar, Intramuscular injection. EDAT- 2016/03/13 06:00 MHDA- 2017/01/14 06:00 CRDT- 2016/03/13 06:00 PHST- 2016/03/13 06:00 [entrez] PHST- 2016/03/13 06:00 [pubmed] PHST- 2017/01/14 06:00 [medline] AID - 7664 [pii] PST - ppublish SO - J Pak Med Assoc. 2016 Mar;66(3):320-3. PMID- 8491244 OWN - NLM STAT- MEDLINE DCOM- 19930611 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 44 IP - 3 DP - 1993 TI - Prevention of postoperative swelling and pain by dexamethasone after operative removal of impacted third molar teeth. PG - 275-7 AB - In a placebo-controlled double-blind study, we examined the effect of perioperative oral administration of 6 mg dexamethasone, given once 12 h before and once 12 h after osteotomy of two impacted molar teeth, on postoperative edema, limitation of jaw opening, and intensity of postoperative pain. On the first day after surgery the difference in the increase in cheek swelling was 54.3% (P < 0.001) as measured with a tape, 46% (P < 0.001) measured with a gauge in the first molar area and 29% (P < or = 0.056) by sonographic measurement of the cheek diameter in the molar area. The limitation in the jaw opening was reduced by 17.7% (P < 0.002) after dexamethasone. Pain assessed by visual analog scale was reduced by dexamethasone by 50% (P < 0.01). The amount of analgesics required postoperatively (codeine phosphate) was reduced by 37% (P = 0.02) following dexamethasone administration. Seventy-six percent of our patients preferred perioperative medication of dexamethasone. FAU - Schmelzeisen, R AU - Schmelzeisen R AD - Department of Oral- and Maxillofacial Surgery, Hannover Medical School, Germany. FAU - Frölich, J C AU - Frölich JC LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 7S5I7G3JQL (Dexamethasone) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Dexamethasone/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Edema/prevention & control MH - Face MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 10.1007/BF00271371 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1993;44(3):275-7. doi: 10.1007/BF00271371. PMID- 9180228 OWN - NLM STAT- MEDLINE DCOM- 19970731 LR - 20190920 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 26 IP - 3 DP - 1997 Jun TI - Mandibular third molar surgery with primary closure and tube drain. PG - 187-90 AB - The insertion of a small surgical tube drain with primary wound closure (drain group) was compared to a simple primary wound closure (no drain group) after removal of impacted third molars. Surgery was performed on 23 patients in a randomized cross-over fashion. The operation time was found to be significantly longer and mouth opening significantly wider in the immediate postoperative period in the drain group subjects as compared to the no drain group (P > or = 0.01). There was no significant difference in the severity of pain between the two groups. Facial swelling was found to be significantly less in the drain group subjects (P > or = 0.01). The number of patients with wound breakdown, edema, and bleeding was found to be less in the drain group than in the no drain group. Thus, the postoperative problems, in general, were less in the small surgical drain group as compared to the no drain group. FAU - Rakprasitkul, S AU - Rakprasitkul S AD - Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Pairuchvej, V AU - Pairuchvej V LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Cross-Over Studies MH - Drainage/instrumentation MH - Edema/etiology MH - Face MH - Female MH - Follow-Up Studies MH - Humans MH - Intubation/instrumentation MH - Male MH - Mandible/physiopathology MH - Molar, Third/*surgery MH - Movement MH - Pain, Postoperative/etiology MH - Postoperative Hemorrhage/etiology MH - Surgical Wound Dehiscence/etiology MH - Time Factors MH - Tooth, Impacted/*surgery EDAT- 1997/06/01 00:00 MHDA- 1997/06/01 00:01 CRDT- 1997/06/01 00:00 PHST- 1997/06/01 00:00 [pubmed] PHST- 1997/06/01 00:01 [medline] PHST- 1997/06/01 00:00 [entrez] AID - 10.1016/s0901-5027(97)80817-x [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1997 Jun;26(3):187-90. doi: 10.1016/s0901-5027(97)80817-x. PMID- 1451712 OWN - NLM STAT- MEDLINE DCOM- 19921231 LR - 20201209 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 43 IP - 4 DP - 1992 TI - Analgesic efficacy of an ibuprofen-codeine combination in patients with pain after removal of lower third molars. PG - 347-50 AB - A double-blind, randomised analgesic trial was carried out in 165 patients undergoing surgical removal of one impacted lower wisdom tooth. In a two-dose regimen, the analgesic efficacy of the combination ibuprofen-codeine 200 mg : 30 mg was compared with that of acetylsalicylic acid-codeine 500 mg : 30 mg and codeine 30 mg. Each dose was taken when the patient needed pain relief. The intensity of the pain was measured on a visual analogue scale during the 10-h period after the first dose. The mean pain reduction by Dose 1 in patients on ibuprofen-codeine, acetylsalicylic acid-codeine and codeine was 64%, 45% and 26%, respectively, and the mean duration of effect was 8.3, 6.3 and 5.6 h. According to the pain reduction, duration of effect and pain reduction index after Doses 1 and 1 + 2, there was a significant difference between ibuprofen-codeine and the other two drugs. The maximum pain reduction within 4 hours was 84% with ibuprofen-codeine. This was significantly different from the reduction achieved both with acetylsalicylic acid-codeine (64%) and codeine (35%). Seventeen patients reported adverse events: 5 on ibuprofen-codeine, 4 on acetylsalicylic acid-codeine and 8 on codeine. The most common events were tiredness and vertigo. It is concluded that the combination ibuprofen-codeine 200 mg : 30 mg had greater analgesic efficacy compared to the combination acetylsalicylic acid-codeine 500 mg : 30 or codeine 30 mg in patients with pain after removal of the lower third molars. FAU - Hellman, M AU - Hellman M AD - Department of Oral Surgery, Institute for Postgraduate Dental Education, Jököping, Sweden. FAU - Ahlström, U AU - Ahlström U FAU - Andersson, L AU - Andersson L FAU - Strid, S AU - Strid S LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Drug Combinations) RN - R16CO5Y76E (Aspirin) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Adolescent MH - Adult MH - *Analgesia MH - Aspirin MH - *Codeine MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - *Ibuprofen MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1992/01/01 00:00 MHDA- 1992/01/01 00:01 CRDT- 1992/01/01 00:00 PHST- 1992/01/01 00:00 [pubmed] PHST- 1992/01/01 00:01 [medline] PHST- 1992/01/01 00:00 [entrez] AID - 10.1007/BF02220607 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1992;43(4):347-50. doi: 10.1007/BF02220607. PMID- 18472528 OWN - NLM STAT- MEDLINE DCOM- 20080710 LR - 20131121 IS - 0377-5291 (Print) IS - 0377-5291 (Linking) VI - 29 IP - 1 DP - 2007 Dec TI - Comparison of two commercially available mouth rinses on gingival inflammation, pain and acceptability after third molar surgery. PG - 34-40 AB - A randomized clinical trial was carried out to compare the difference in the effects of using two different mouth rinses on healing after surgical removal of wisdom teeth. One mouth rinse contained chlorhexidine with alcohol whereas the other was chlorhexidine without alcohol. Twenty-one patients without any medical conditions underwent surgical removal of their 3rd molars by the same operator on both the sides. Data were analysed by the non-parametric function test. Significant differences were shown in the pain score and the number of inflammation sites (p > 0.05). There was no significant difference in the acceptability of the two mouth rinses. In this study, nonalcohol chlorhexidine mouth rinse seemed better than an alcohol-containing chlorhexidine mouth rinse in diminishing patients' post-operative pain and wound inflammation. Non-alcohol chlorhexidine mouth rinse had similar properties without the adverse effects of alcohol, such as dryness of the mouth and addiction. Likewise, they were less likely to result in alcohol-induced pain. FAU - Chew, Bertrand AU - Chew B AD - Alexandra Hospital, Singapore. bertrandchew@gmail.com FAU - Cheng, Wu Loo AU - Cheng WL FAU - Tay, Sylvia AU - Tay S FAU - Fei, Yeo Jin AU - Fei YJ LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Singapore TA - Singapore Dent J JT - Singapore dental journal JID - 7513690 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Mouthwashes) RN - 0 (Solvents) RN - 3K9958V90M (Ethanol) RN - MOR84MUD8E (chlorhexidine gluconate) RN - R4KO0DY52L (Chlorhexidine) SB - D MH - Adult MH - Anti-Infective Agents, Local/*therapeutic use MH - Chlorhexidine/*analogs & derivatives/therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Ethanol/*therapeutic use MH - Gingivitis/*prevention & control MH - Humans MH - Molar, Third/*surgery MH - Mouthwashes/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Patient Compliance MH - *Patient Satisfaction MH - Prospective Studies MH - Solvents/*therapeutic use MH - Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2008/05/14 09:00 MHDA- 2008/07/11 09:00 CRDT- 2008/05/14 09:00 PHST- 2008/05/14 09:00 [pubmed] PHST- 2008/07/11 09:00 [medline] PHST- 2008/05/14 09:00 [entrez] PST - ppublish SO - Singapore Dent J. 2007 Dec;29(1):34-40. PMID- 9668994 OWN - NLM STAT- MEDLINE DCOM- 19980924 LR - 20041117 IS - 0301-228X (Print) IS - 0301-228X (Linking) VI - 25 IP - 2 DP - 1998 May TI - The effect of extraction of third molars on late lower incisor crowding: a randomized controlled trial. PG - 117-22 AB - The problem of late mandibular incisor crowding is a well established phenomenon, the cause of which has been the substance of considerable debate over the years. A central issue is the possible role of the third molars though no definitive conclusions have been consistently drawn. This prospective study was designed to investigate the effects of randomly assigned early extraction of third molars on late crowding of the mandibular incisors. One-hundred-and-sixty-four patients entered the study from 1984 following completion of retention after orthodontic treatment. Seventy-seven patients (47%) returned for records up to a mean of 66 months later, and their start and finish study casts were digitized on a reflex microscope to determine Little's index of irregularity, intercanine width and arch length. Forty-four of the patients had been randomized to have third molars removed. There was no evidence of responder bias. Where third molars were extracted the mean increase in lower labial segment irregularity was reduced by 1.1 mm from a mean of 2.1 mm for the group where third molars were retained (P = 0.15, not statistically significant). This difference was also not considered to be clinically significant. The principal conclusion drawn from this randomized prospective study is that the removal of third molars to reduce or prevent late incisor crowding cannot be justified. FAU - Harradine, N W AU - Harradine NW AD - Division of Child Dental Health, University of Bristol Dental School, U.K. FAU - Pearson, M H AU - Pearson MH FAU - Toth, B AU - Toth B LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br J Orthod JT - British journal of orthodontics JID - 0376035 SB - D SB - IM MH - Adolescent MH - Confidence Intervals MH - Cuspid/pathology MH - Dental Arch/pathology MH - Dental Models MH - Female MH - Follow-Up Studies MH - Humans MH - Image Processing, Computer-Assisted MH - Incisor/*pathology MH - Linear Models MH - Male MH - Malocclusion/etiology/pathology/*therapy MH - Mandible MH - Molar, Third/*surgery MH - Prospective Studies MH - Time Factors MH - *Tooth Extraction EDAT- 1998/07/21 00:00 MHDA- 1998/07/21 00:01 CRDT- 1998/07/21 00:00 PHST- 1998/07/21 00:00 [pubmed] PHST- 1998/07/21 00:01 [medline] PHST- 1998/07/21 00:00 [entrez] AID - 10.1093/ortho/25.2.117 [doi] PST - ppublish SO - Br J Orthod. 1998 May;25(2):117-22. doi: 10.1093/ortho/25.2.117. PMID- 2645933 OWN - NLM STAT- MEDLINE DCOM- 19890411 LR - 20190912 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 27 IP - 1 DP - 1989 Feb TI - Do local analgesics injected at the time of third molar removal under general anaesthesia reduce significantly post operative analgesic requirements? A double-blind controlled trial. PG - 27-32 AB - A prospective, controlled, randomised, double-blind trial suggested that: 1. The use of bupivacaine 0.5% plain and prilocaine 3% with felypressin 0.03 i.u./ml. as peroperative local analgesics reduce postoperative pain scores recorded on the first postoperative morning (P less than 0.05). 2. Bupivacaine 0.5% plain reduces postoperative opiate requirements (P less than 0.025). 3. Patients do not find peroperative bilateral inferior alveolar and lingual nerve blocks with buccal infiltrations significantly unpleasant. Thus peri-operative bupivacaine 0.5% is a valuable adjunct to third molar removal under general anaesthesia. FAU - Tuffin, J R AU - Tuffin JR AD - Department of Oral Surgery, Plymouth General Hospital, Devon. FAU - Cunliffe, D R AU - Cunliffe DR FAU - Shaw, S R AU - Shaw SR LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Analgesics) RN - 046O35D44R (Prilocaine) RN - Y8335394RO (Bupivacaine) SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 1989 Oct;27(5):437. PMID: 2804048 MH - Adolescent MH - Adult MH - Analgesics/administration & dosage MH - *Anesthesia, Dental MH - *Anesthesia, General MH - Bupivacaine/*administration & dosage MH - Clinical Trials as Topic MH - Double-Blind Method MH - Female MH - Humans MH - Intraoperative Care MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Prilocaine/*administration & dosage MH - Prospective Studies MH - Random Allocation MH - *Tooth Extraction EDAT- 1989/02/01 00:00 MHDA- 1989/02/01 00:01 CRDT- 1989/02/01 00:00 PHST- 1989/02/01 00:00 [pubmed] PHST- 1989/02/01 00:01 [medline] PHST- 1989/02/01 00:00 [entrez] AID - 0266-4356(89)90123-X [pii] AID - 10.1016/0266-4356(89)90123-x [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1989 Feb;27(1):27-32. doi: 10.1016/0266-4356(89)90123-x. PMID- 12666865 OWN - NLM STAT- MEDLINE DCOM- 20030603 LR - 20060711 IS - 0033-6572 (Print) IS - 0033-6572 (Linking) VI - 34 IP - 2 DP - 2003 Feb TI - Effects of tube drain with primary closure technique on postoperative trismus and swelling after removal of fully impacted mandibular third molars. PG - 143-7 AB - OBJECTIVE: Surgical removal of impacted mandibular third molars with primary wound closure may result in postoperative edema, facial swelling, pain, and restriction of mouth opening. The type of closure may be a cause of these complications. The aim of this study was to compare the effects of placement of a surgical tube drain before primary closure with the effects of primary closure alone after removal of fully impacted mandibular third molars. METHOD AND MATERIALS: The study group included 13 patients aged 15 to 39 years with bilateral fully impacted mandibular third molars. The insertion of a small surgical tube drain before primary closure (drain group) was compared to a simple primary closure procedure (no drain group) after removal of the impacted third molars in a randomized crossover design. The duration of the operation was recorded. Patients were evaluated 1, 2, 3, and 7 days postoperatively for facial swelling and trismus. RESULTS: The facial swelling experienced by the drain group was significantly less than that experienced by the no drain group. The degree of trismus was greater in the no drain group than in the drain group, but the difference was not statistically significant. CONCLUSION: Use of a surgical drain, especially after removal of fully impacted third molars, will reduce postoperative facial swelling. FAU - Sağlam, Ali Alp AU - Sağlam AA AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey. aasaglam@hotmail.com LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Adolescent MH - Adult MH - Drainage/*instrumentation MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Postoperative Care MH - Tooth Extraction/*adverse effects/*instrumentation MH - Tooth, Impacted/surgery MH - Trismus/etiology/prevention & control EDAT- 2003/04/02 05:00 MHDA- 2003/06/05 05:00 CRDT- 2003/04/02 05:00 PHST- 2003/04/02 05:00 [pubmed] PHST- 2003/06/05 05:00 [medline] PHST- 2003/04/02 05:00 [entrez] PST - ppublish SO - Quintessence Int. 2003 Feb;34(2):143-7. PMID- 15790675 OWN - NLM STAT- MEDLINE DCOM- 20050526 LR - 20180126 IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 94 IP - 5 DP - 2005 May TI - Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. PG - 642-8 AB - BACKGROUND: The purpose of this randomized double-blind study was to compare the efficacy and safety of propacetamol 2 g (an i.v. acetaminophen 1 g formulation) administered as a 2-min bolus injection (n=50) or a 15-min infusion (n=50) with oral acetaminophen 1 g (n=50) or placebo (n=25) for analgesia after third molar surgery in patients with moderate to severe pain after impacted third molar removal. METHODS: All patients were evaluated for efficacy during the initial 6 h period after treatment administration (T(0)) and for safety during the entire week after T(0). RESULTS: The onset of analgesia after propacetamol was shorter (3 min for bolus administration, 5 min for 15-min infusion) than after oral acetaminophen (11 min). Active treatments were significantly better for all parameters (pain relief, pain intensity, patient's global evaluation, duration of analgesia) than placebo (P<0.05). Adverse events were more frequent after propacetamol, especially pain at the injection site. Propacetamol bolus resulted in a much higher incidence of local adverse events than the infusion (propacetamol bolus 90% vs propacetamol infusion 52%) with no clinically significant benefits in terms of analgesic efficacy. CONCLUSION: I.V. propacetamol, administered as a 15-min infusion, is a fast-acting analgesic agent. It is more effective in terms of onset of analgesia than a similar dose of oral acetaminophen. FAU - Moller, P L AU - Moller PL AD - Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, DK-800 Aarhus, Denmark. plm@dadlnet.dk FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S FAU - Petersen, C T AU - Petersen CT FAU - Juhl, G I AU - Juhl GI FAU - Dillenschneider, A AU - Dillenschneider A FAU - Skoglund, L A AU - Skoglund LA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20050324 PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) RN - 5CHW4JMR82 (propacetamol) SB - IM CIN - Br J Anaesth. 2011 Oct;107(4):638; author reply 638-9. PMID: 21903646 MH - Acetaminophen/*administration & dosage/adverse effects/*analogs & derivatives MH - Administration, Oral MH - Adult MH - Analgesics, Non-Narcotic/*administration & dosage/adverse effects MH - Double-Blind Method MH - Female MH - Humans MH - Infusions, Intravenous MH - Injections, Intravenous MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement/methods MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2005/03/26 09:00 MHDA- 2005/05/27 09:00 CRDT- 2005/03/26 09:00 PHST- 2005/03/26 09:00 [pubmed] PHST- 2005/05/27 09:00 [medline] PHST- 2005/03/26 09:00 [entrez] AID - S0007-0912(17)35634-9 [pii] AID - 10.1093/bja/aei109 [doi] PST - ppublish SO - Br J Anaesth. 2005 May;94(5):642-8. doi: 10.1093/bja/aei109. Epub 2005 Mar 24. PMID- 33419167 OWN - NLM STAT- MEDLINE DCOM- 20210318 LR - 20210318 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 18 IP - 2 DP - 2021 Jan 6 TI - The Impact of Using Kinesio Tape on Non-Infectious Complications after Impacted Mandibular Third Molar Surgery. LID - 10.3390/ijerph18020399 [doi] LID - 399 AB - Non-infectious complications such as post-extraction pain, trismus, and swelling are extremely common after impacted wisdom tooth removal. The aim of the study was to assess the impact of using kinesio tape on the level of the postoperative swelling of soft tissues, trismus, and pain in patients undergoing the surgical extraction of an impacted mandibular third molar. One hundred patients undergoing the surgical extraction of a lower wisdom tooth were randomly divided into two groups: a study group with kinesio taping (KT) (n = 50) and a control group without kinesio taping (NKT) (n = 50). The surgical procedure was performed according to the same repeatable scheme. Kinesio tape was applied immediately after surgery in the KT group. In both groups, measurements of swelling, trismus, and pain were performed before the surgery and on the third and seventh postprocedural days. Kinesio tape had a significant effect on the decrease in facial swelling on the third day after surgery and a decrease in trismus and pain severity levels on the third and seventh days after surgery. The kinesio tape method is non-invasive, continuously active throughout the entire application period, and requires no additional patient appointments. KT application is an effective method for reducing postoperative edema, pain, and trismus after impacted mandibular wisdom teeth surgery. FAU - Jaroń, Aleksandra AU - Jaroń A AUID- ORCID: 0000-0001-7727-6388 AD - Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72/18, 70-111 Szczecin, Poland. FAU - Preuss, Olga AU - Preuss O AD - Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72/18, 70-111 Szczecin, Poland. FAU - Grzywacz, Elżbieta AU - Grzywacz E AD - Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72/18, 70-111 Szczecin, Poland. FAU - Trybek, Grzegorz AU - Trybek G AUID- ORCID: 0000-0002-3900-4901 AD - Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72/18, 70-111 Szczecin, Poland. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20210106 TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - *Athletic Tape MH - Humans MH - Molar, Third/surgery MH - Pain, Postoperative MH - *Tooth, Impacted/surgery MH - Trismus/etiology PMC - PMC7825547 OTO - NOTNLM OT - *complications OT - *edema OT - *kinesio taping OT - *morbidity OT - *pain OT - *swelling OT - *third molar removal OT - *trismus COIS- The authors declare no conflict of interest. EDAT- 2021/01/10 06:00 MHDA- 2021/03/19 06:00 CRDT- 2021/01/09 01:02 PHST- 2020/11/17 00:00 [received] PHST- 2020/12/17 00:00 [revised] PHST- 2020/12/31 00:00 [accepted] PHST- 2021/01/09 01:02 [entrez] PHST- 2021/01/10 06:00 [pubmed] PHST- 2021/03/19 06:00 [medline] AID - ijerph18020399 [pii] AID - ijerph-18-00399 [pii] AID - 10.3390/ijerph18020399 [doi] PST - epublish SO - Int J Environ Res Public Health. 2021 Jan 6;18(2):399. doi: 10.3390/ijerph18020399. PMID- 26332915 OWN - NLM STAT- MEDLINE DCOM- 20170118 LR - 20170118 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 33 IP - 9 DP - 2015 Sep TI - A Comparative Study of the Effectiveness of Immediate Versus Delayed Photobiomodulation Therapy in Reducing the Severity of Postoperative Inflammatory Complications. PG - 447-51 LID - 10.1089/pho.2015.3923 [doi] AB - OBJECTIVE: The aim of this study was to compare the immediate versus the delayed application of photobiomodulation (PBM) therapy following odontectomy of horizontally impacted mandibular third molars, and assess which application method is more effective at reducing postoperative complications. BACKGROUND DATA: Surgical removal of horizontally impacted mandibular third molars is a common surgical procedure, usually associated with postoperative complications such as pain, swelling, and trismus. Several attempts have been made to minimize these complications. One such method is the use of PBM therapy. METHODS: Eighty patients with horizontally impacted mandibular third molars with no inferior alveolar canal approximation were recruited for this study. They were divided into two groups. The immediate group received PBM therapy immediately after surgery and on the 3rd day postoperatively. Subjects in the delayed group received PBM therapy on the 2nd and 4th days postoperatively. All subjects received 2 min of treatment using a 4 W laser beam, during which 171 J were delivered via a 2.8 cm(2) spot size. RESULTS: Clinical and statistical results showed a significant reduction in pain, trismus, and swelling in the immediate PBM therapy group compared with the delayed PBM therapy group. CONCLUSIONS: Immediate PBM therapy is more effective than delayed PBM therapy in minimizing the complications associated with mandibular third molar removal surgery. FAU - Abdel-Alim, Hala M AU - Abdel-Alim HM AD - 1 Oral and Maxillofacial Surgery, Faculty of Dentistry, King Abdulaziz University , Jeddah, Saudi Arabia . FAU - Abdel-Dayem, Hassan AU - Abdel-Dayem H AD - 2 Oral and Maxillofacial Surgery, Alfarabi Dental and Nursing Colleges , Jeddah, Saudi Arabia . FAU - Mustafa, Zeinab A AU - Mustafa ZA AD - 1 Oral and Maxillofacial Surgery, Faculty of Dentistry, King Abdulaziz University , Jeddah, Saudi Arabia . FAU - Bayoumi, Amr AU - Bayoumi A AD - 1 Oral and Maxillofacial Surgery, Faculty of Dentistry, King Abdulaziz University , Jeddah, Saudi Arabia . FAU - Jan, Ahmed AU - Jan A AD - 1 Oral and Maxillofacial Surgery, Faculty of Dentistry, King Abdulaziz University , Jeddah, Saudi Arabia . FAU - Jadu, Fatima AU - Jadu F AD - 1 Oral and Maxillofacial Surgery, Faculty of Dentistry, King Abdulaziz University , Jeddah, Saudi Arabia . LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 SB - IM MH - Adolescent MH - Adult MH - Edema/etiology/therapy MH - Female MH - Humans MH - *Low-Level Light Therapy MH - Male MH - Molar, Third MH - Postoperative Complications/*therapy MH - Prospective Studies MH - *Tooth Extraction MH - Trismus/therapy MH - Young Adult EDAT- 2015/09/04 06:00 MHDA- 2017/01/19 06:00 CRDT- 2015/09/03 06:00 PHST- 2015/09/03 06:00 [entrez] PHST- 2015/09/04 06:00 [pubmed] PHST- 2017/01/19 06:00 [medline] AID - 10.1089/pho.2015.3923 [doi] PST - ppublish SO - Photomed Laser Surg. 2015 Sep;33(9):447-51. doi: 10.1089/pho.2015.3923. PMID- 28067086 OWN - NLM STAT- MEDLINE DCOM- 20170803 LR - 20170803 IS - 0030-6002 (Print) IS - 0030-6002 (Linking) VI - 158 IP - 1 DP - 2017 Jan TI - [Prospective randomized study regarding the effect of the preoperative antibiotic and chlorhexidine rinse on wound healing after mandibular third molar surgery]. PG - 13-19 LID - 10.1556/650.2017.30645 [doi] AB - INTRODUCTION AND AIM: The study compares the antibiotic prophylaxis combined with postoperative antibiotic therapy to preoperative chlorhexidine rinse combined with postoperative antibiotic therapy in preventing complications after surgical removal of a mandibular third molar. METHOD: 71 healthy patients in four groups were enrolled in the study: I. prophylactic dose of 2000 mg of amoxicillin clavulanate, continued with amoxicillin clavulanate postoperatively; II. prophylactic dose of 600 mg of clindamycin, continued with clindamycin postoperatively; III. prophylactic chlorhexidin rinsing, continued randomized amoxicillin clavulanate or clindamycin postoperatively; IV. control, with clindamycin postoperatively. RESULTS: The pain was smaller in the prophylaxis groups. Alveolitis occurred only in the control group: 2 patients. Wound opening occurred in 22,2 % in group IV., 14,2 % in group II, 10 % in group I., 5 % in group III. CONCLUSION: We consider completing the indicated postoperative antibiotic prescription with antibiotic or antiseptic prophylaxis. Chlorhexidin prophylaxis could have the same positive effect. Orv. Hetil., 2017, 158(1), 13-19. FAU - Kaposvári, István AU - Kaposvári I AD - Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Fogorvos-tudományi Kar Budapest. FAU - Körmöczi, Kinga AU - Körmöczi K AD - Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Fogorvos-tudományi Kar Budapest. FAU - László, Zsuzsa Beáta AU - László ZB AD - Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Fogorvos-tudományi Kar Budapest. FAU - Oberna, Ferenc AU - Oberna F AD - Arc-, Állcsont-, Szájsebészeti és Fül-Orr-Gégészeti Osztály, Bács-Kiskun Megyei Kórház Kecskemét. FAU - Horváth, Ferenc AU - Horváth F AD - Népegészségtani Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest. FAU - Joób-Fancsaly, Árpád AU - Joób-Fancsaly Á AD - Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Fogorvos-tudományi Kar Budapest. LA - hun PT - Journal Article PT - Randomized Controlled Trial TT - A preoperatív antibiotikus és antiszeptikus kezelés hatása a műtéti úton eltávolított alsó bölcsességfogak sebgyógyulására – prospektív randomizált vizsgálat. PL - Hungary TA - Orv Hetil JT - Orvosi hetilap JID - 0376412 RN - 0 (Anti-Bacterial Agents) RN - 3U02EL437C (Clindamycin) RN - 804826J2HU (Amoxicillin) SB - IM MH - Amoxicillin/therapeutic use MH - Anti-Bacterial Agents/*therapeutic use MH - *Antibiotic Prophylaxis MH - Clindamycin/therapeutic use MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Treatment Outcome OTO - NOTNLM OT - alsó bölcsességfog OT - antibiotic prophylaxis OT - antibiotikum-profilaxis OT - chlorhexidine OT - klórhexidin OT - mandibular third molar OT - postoperative complications OT - sebgyógyulás OT - wound healing EDAT- 2017/01/10 06:00 MHDA- 2017/08/05 06:00 CRDT- 2017/01/10 06:00 PHST- 2017/01/10 06:00 [entrez] PHST- 2017/01/10 06:00 [pubmed] PHST- 2017/08/05 06:00 [medline] AID - 10.1556/650.2017.30645 [doi] PST - ppublish SO - Orv Hetil. 2017 Jan;158(1):13-19. doi: 10.1556/650.2017.30645. PMID- 15966878 OWN - NLM STAT- MEDLINE DCOM- 20050914 LR - 20061030 IS - 0303-6979 (Print) IS - 0303-6979 (Linking) VI - 32 IP - 7 DP - 2005 Jul TI - A regimen of systematic periodontal care after removal of impacted mandibular third molars manages periodontal pockets associated with the mandibular second molars. PG - 725-31 AB - AIM: This randomized, single-blinded control trial investigated the local effects of periodontal care on the mandibular second molar delivered during and after impacted third molar surgical extraction. METHOD: Thirty subjects (50% male, 32.1+/-7.8 years) out of 35 enrolled, with a mesio-angular impacted mandibular third molar, having probing pocket depth (PPD) >5 mm at adjacent second molar distal, and crestal radio-lucency between the two teeth, completed the study. Oral hygiene instruction, scaling and caries stabilization were performed before surgery. Controls (n=16) had their third molar extracted followed by standard socket debridement. Test group subjects (n=14) received the same treatment, except that before wound closure the operator was informed of the group allocation and ultrasonic root debridement on the second molar was performed, followed by a three-visit plaque control programme. RESULTS: Six months post-extraction, statistically significantly (p<0.007) better plaque control and shallower probing depths were observed at test second molars' distal (%plaque=21; PPD=3.2+/-1.2 mm) than at control second molars (%plaque=88; PPD=5.2+/-0.7 mm). CONCLUSIONS: The periodontal interventions investigated prevented residual pockets on periodontally involved second molars 6 months after ipsilateral impacted mandibular third molar removal. FAU - Leung, W Keung AU - Leung WK AD - Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. ewkleung@hkucc.hku.hk FAU - Corbet, Esmonde F AU - Corbet EF FAU - Kan, Kwok Wing AU - Kan KW FAU - Lo, Edward C M AU - Lo EC FAU - Liu, Jerry K S AU - Liu JK LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 SB - D SB - IM MH - Adult MH - Alveolar Bone Loss/complications/*therapy MH - Data Interpretation, Statistical MH - Dental Plaque/prevention & control MH - *Dental Scaling MH - Female MH - Humans MH - Male MH - Mandible MH - Molar/pathology MH - Molar, Third/*surgery MH - Periodontal Pocket/*therapy MH - Postoperative Care MH - Sample Size MH - Single-Blind Method MH - Subgingival Curettage MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/complications/surgery MH - Ultrasonic Therapy EDAT- 2005/06/22 09:00 MHDA- 2005/09/15 09:00 CRDT- 2005/06/22 09:00 PHST- 2005/06/22 09:00 [pubmed] PHST- 2005/09/15 09:00 [medline] PHST- 2005/06/22 09:00 [entrez] AID - CPE773 [pii] AID - 10.1111/j.1600-051X.2005.00773.x [doi] PST - ppublish SO - J Clin Periodontol. 2005 Jul;32(7):725-31. doi: 10.1111/j.1600-051X.2005.00773.x. PMID- 21697156 OWN - NLM STAT- MEDLINE DCOM- 20110906 LR - 20181113 IS - 0250-832X (Print) IS - 1476-542X (Electronic) IS - 0250-832X (Linking) VI - 40 IP - 5 DP - 2011 Jul TI - Accuracy of scanography using storage phosphor plate systems and film for assessment of mandibular third molars. PG - 306-9 LID - 10.1259/dmfr/68783877 [doi] AB - OBJECTIVES: The aim of this study was to compare the diagnostic accuracy of two digital photostimulable storage phosphor (PSP) systems and film for assessment of mandibular third molars before surgery. METHODS: 110 patients were referred to have both their mandibular third molars removed. Each patient underwent a radiographic examination with scanography using either Digora (Soredex, Helsinki, Finland) and film or VistaScan (Dürr Dental, Beitigheim-Bissingen, Germany) and film in a randomized paired design. Two observers examined the following variables on the scanograms: bone coverage, angulation of the tooth in the bone, number of roots, root morphology and the relationship to the mandibular canal. In 75 of the pairs (Digora/film pair = 38 and Vista/film pair = 37) both third molars were eventually removed. During and after surgery the same variables were assessed, which served as reference standard for the radiographic assessments. The Wilcoxon signed-rank test tested differences in accuracy (radiographic compared with surgical findings) between Digora/film and between Vista/film. RESULTS: There was no statistically significant difference between the diagnostic accuracy of film and either of the two digital receptors for assessment of mandibular third molars before surgery (P > 0.05), although Digora obtained a higher accuracy than film. CONCLUSIONS: Scanography is a valuable method for examination of mandibular third molars before removal and the PSP digital receptors in this study were equal to film for this purpose. FAU - Matzen, L H AU - Matzen LH AD - Louise Hauge Matzen, Department of Oral Radiology, School of Dentistry, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark. louise.hauge.matzen@odontologi.au.dk FAU - Christensen, J AU - Christensen J FAU - Wenzel, A AU - Wenzel A LA - eng PT - Journal Article PT - Randomized Controlled Trial TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - D MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Mandible MH - Mandibular Nerve/diagnostic imaging MH - Middle Aged MH - Molar, Third/*diagnostic imaging/surgery MH - Radiography, Dental, Digital/*instrumentation/*methods MH - Statistics, Nonparametric MH - Tooth Extraction MH - Tooth Root/*diagnostic imaging MH - X-Ray Film MH - *X-Ray Intensifying Screens MH - Young Adult PMC - PMC3520266 EDAT- 2011/06/24 06:00 MHDA- 2011/09/07 06:00 CRDT- 2011/06/24 06:00 PHST- 2011/06/24 06:00 [entrez] PHST- 2011/06/24 06:00 [pubmed] PHST- 2011/09/07 06:00 [medline] AID - 40/5/306 [pii] AID - D10210 [pii] AID - 10.1259/dmfr/68783877 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 2011 Jul;40(5):306-9. doi: 10.1259/dmfr/68783877. PMID- 10551056 OWN - NLM STAT- MEDLINE DCOM- 19991117 LR - 20181130 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 46 IP - 1 DP - 1999 Winter TI - Use of sevoflurane inhalation sedation for outpatient third molar surgery. PG - 21-9 AB - This study attempted to determine if sevoflurane in oxygen inhaled via a nasal hood as a sole sedative agent would provide an appropriate level of deep sedation for outpatient third molar surgery. Twenty-four patients scheduled for third molar removal were randomly assigned to receive either nasal hood inhalation sevoflurane or an intravenous deep sedation using midazolam and fentanyl followed by a propofol infusion. In addition to measuring patient, surgeon, and dentist anesthesiologist subjective satisfaction with the technique, physiological parameters, amnesia, and psychomotor recovery were also assessed. No statistically significant difference was found between the sevoflurane and midazolam-fentanyl-propofol sedative groups in physiological parameters, degree of amnesia, reported quality of sedation, or patient willingness to again undergo a similar deep sedation. A trend toward earlier recovery in the sevoflurane group was identified. Sevoflurane can be successfully employed as a deep sedative rather than a general anesthetic for extraction of third molars in healthy subjects. FAU - Ganzberg, S AU - Ganzberg S AD - Ohio State University, College of Dentistry, Columbus 43210, USA. ganzberg.1@osu.edu FAU - Weaver, J AU - Weaver J FAU - Beck, F M AU - Beck FM FAU - McCaffrey, G AU - McCaffrey G LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Anesthetics, Combined) RN - 0 (Anesthetics, Inhalation) RN - 0 (Anesthetics, Intravenous) RN - 0 (Hypnotics and Sedatives) RN - 0 (Methyl Ethers) RN - 38LVP0K73A (Sevoflurane) RN - K50XQU1029 (Nitrous Oxide) RN - R60L0SM5BC (Midazolam) RN - UF599785JZ (Fentanyl) RN - YI7VU623SF (Propofol) SB - D MH - Adolescent MH - Adult MH - *Anesthesia, Dental MH - Anesthetics, Combined MH - *Anesthetics, Inhalation MH - Anesthetics, Intravenous MH - Conscious Sedation MH - Female MH - Fentanyl MH - Humans MH - Hypnotics and Sedatives MH - Male MH - *Methyl Ethers MH - Midazolam MH - Molar, Third/*surgery MH - Nitrous Oxide MH - Pilot Projects MH - Propofol MH - Sevoflurane MH - Surveys and Questionnaires MH - *Tooth Extraction PMC - PMC2148884 EDAT- 1999/11/07 00:00 MHDA- 1999/11/07 00:01 CRDT- 1999/11/07 00:00 PHST- 1999/11/07 00:00 [pubmed] PHST- 1999/11/07 00:01 [medline] PHST- 1999/11/07 00:00 [entrez] PST - ppublish SO - Anesth Prog. 1999 Winter;46(1):21-9. PMID- 25961614 OWN - NLM STAT- MEDLINE DCOM- 20170123 LR - 20170123 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 26 IP - 1 DP - 2015 Jan-Feb TI - C-reactive protein estimation: a quantitative analysis for three nonsteroidal anti-inflammatory drugs: a randomized control trial. PG - 43-7 LID - 10.4103/0970-9290.156797 [doi] AB - CONTEXT: C-reactive protein (CRP) estimation for quantitative analysis to assess anti-inflammatory action of nonsteroidal anti-inflammatory drugs (NSAIDs) after surgery in maxillofacial surgery. AIMS: This study was to evaluate the efficacy of CRP as a quantitative analysis for objective assessment of efficacy of three NSAIDs in postoperative inflammation and pain control. SETTINGS AND DESIGN: The parallel study group design of randomization was done. Totally 60 patients were divided into three groups. CRP was evaluated at baseline and postoperatively (immediate and 72 h) after surgical removal of impacted lower third molar. The respective group received the drugs by random coding postoperatively. SUBJECTS AND METHODS: The assessment of pain control and inflammation using NSAIDs postoperatively after surgical removal of impacted lower third molar was qualitatively and quantitatively assessed with CRP levels. The blood sample of the patient was assessed immediate postoperatively and after 72 h. The visual analog scale (VAS) was used for assessment of pain and its correlation with CRP levels. STATISTICAL ANALYSIS: Comparison of difference in levels of CRP levels had P < 0.05 with immediate postoperative and baseline levels. The duration of surgery with association of CRP levels P = 0.425 which was nonsignificant. The pain score was increased with mefenamic acid (P = 0.003), which was significant on VAS. RESULTS: Diclofenac had the best anti-inflammatory action. There was a significant increase in CRP levels in immediate postoperative values and 72 h. CRP test proved to be a useful indicator as a quantitative assessment tool for monitoring postsurgical inflammation and therapeutic effects of various anti-inflammatory drugs. CONCLUSIONS: CRP test is a useful indicator for quantitative assessment for comparative evaluation of NSAIDs. FAU - Salgia, Gaurav AU - Salgia G FAU - Kulkarni, Deepak G AU - Kulkarni DG FAU - Shetty, Lakshmi AU - Shetty L AD - Department of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 144O8QL0L1 (Diclofenac) RN - 367589PJ2C (Mefenamic Acid) RN - 9007-41-4 (C-Reactive Protein) RN - WK2XYI10QM (Ibuprofen) SB - D MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - C-Reactive Protein/*analysis MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Mandible/diagnostic imaging/surgery MH - Mefenamic Acid/*therapeutic use MH - Molar, Third/diagnostic imaging/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Radiography, Panoramic MH - Tooth, Impacted/diagnostic imaging/*surgery MH - Treatment Outcome EDAT- 2015/05/12 06:00 MHDA- 2017/01/24 06:00 CRDT- 2015/05/12 06:00 PHST- 2015/05/12 06:00 [entrez] PHST- 2015/05/12 06:00 [pubmed] PHST- 2017/01/24 06:00 [medline] AID - IndianJDentRes_2015_26_1_43_156797 [pii] AID - 10.4103/0970-9290.156797 [doi] PST - ppublish SO - Indian J Dent Res. 2015 Jan-Feb;26(1):43-7. doi: 10.4103/0970-9290.156797. PMID- 21752507 OWN - NLM STAT- MEDLINE DCOM- 20111229 LR - 20161125 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 11 DP - 2011 Nov TI - Assessment of factors associated with surgical difficulty during removal of impacted lower third molars. PG - 2714-21 LID - 10.1016/j.joms.2011.02.097 [doi] AB - PURPOSE: The aim of the present study was to adjust a multivariate model to explain each of the response variables for the occurrence of surgical difficulty during the removal of impacted lower third molars. PATIENTS AND METHODS: A prospective cohort study was carried out involving patients submitted to at least one surgical removal of an impacted lower third molar. A total of 285 patients fulfilled the eligibility criteria and 473 surgeries were performed. Preoperative variables indicative of surgical difficulty were recorded. All surgical procedures were performed under the same conditions by two surgeons who were unaware of the data collected in the pre-selection phase. Either Pearson's chi-square test or Fisher's exact test was used for the data analysis (P<5.0%). RESULTS: Root number (P((1)) < 0.004*) and morphology (P((1)) < 0.031*), tooth position (P((1)) = 0.001*), periodontal space (P((2)) < 0.004*) and second molar relation (P((1)) = 0.001*) were significant predictors of surgical difficulty, whereas patient age (P((1)) = 0.097), gender (P((1)) = 0.470), body mass index (P((1)) = 0.719), associated pathologies (P((1)) = 0.237), relation with mandibular canal (P((1)) = 0.384) and width of 3rd molar crown (P((1)) = 0.154) were not significant predictors. CONCLUSION: Many factors contribute to surgical difficulty, but considering these factors individually, some are only determinants of either difficulty or complications. Thus, not all significant predictors of surgical difficulty should be considered indicators of complications. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Carvalho, Ricardo Wathson F AU - Carvalho RW AD - Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil. FAU - do Egito Vasconcelos, Belmiro Cavalcanti AU - do Egito Vasconcelos BC LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20110712 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adult MH - Age Factors MH - Body Mass Index MH - Bone Resorption/complications MH - Cohort Studies MH - Dental Caries/complications MH - Female MH - Forecasting MH - Humans MH - Male MH - Mandible/diagnostic imaging/*surgery MH - Molar/pathology MH - Molar, Third/diagnostic imaging/*surgery MH - Osteotomy/methods MH - Pericoronitis/complications MH - Periodontium/pathology MH - Prospective Studies MH - Radiography, Panoramic MH - Risk Factors MH - Sex Factors MH - Time Factors MH - Tooth Apex/diagnostic imaging MH - Tooth Crown/diagnostic imaging/pathology MH - Tooth Extraction/*methods MH - Tooth Root/diagnostic imaging MH - Tooth, Impacted/classification/diagnostic imaging/*surgery MH - Treatment Outcome MH - Young Adult EDAT- 2011/07/15 06:00 MHDA- 2011/12/30 06:00 CRDT- 2011/07/15 06:00 PHST- 2010/08/17 00:00 [received] PHST- 2011/01/30 00:00 [revised] PHST- 2011/02/16 00:00 [accepted] PHST- 2011/07/15 06:00 [entrez] PHST- 2011/07/15 06:00 [pubmed] PHST- 2011/12/30 06:00 [medline] AID - S0278-2391(11)00325-9 [pii] AID - 10.1016/j.joms.2011.02.097 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Nov;69(11):2714-21. doi: 10.1016/j.joms.2011.02.097. Epub 2011 Jul 12. PMID- 15120774 OWN - NLM STAT- MEDLINE DCOM- 20040707 LR - 20141120 IS - 0885-3924 (Print) IS - 0885-3924 (Linking) VI - 27 IP - 5 DP - 2004 May TI - Valdecoxib versus rofecoxib in acute postsurgical pain: results of a randomized controlled trial. PG - 460-70 AB - The analgesic efficacy of the cyclooxygenase-2 specific inhibitors, valdecoxib and rofecoxib, were evaluated in patients following oral surgery. In a randomized, double-blind, controlled trial, patients experiencing moderate or severe pain received single-dose valdecoxib 40 mg (n=99), rofecoxib 50 mg (n=101), or placebo (n=50) within 4 hours after multiple third molar extraction with bone removal. Onset of action was significantly faster with valdecoxib 40 mg (30 minutes) compared with rofecoxib 50 mg (45 minutes), as measured by pain intensity difference and pain relief scores (P 0.05). The alternative flap exhibited higher pain scores at 12h post-surgery (P<0.05). In addition, the alternative flap group exhibited less wound dehiscence, although this was not statistically significant. Moreover, all wound dehiscence in this group occurred on sound bone. In conclusion, these results show that this new flap design is preferable to the routinely used flap for impacted third molar surgery. CI - Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Yolcu, Ü AU - Yolcu Ü AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Inönü University, Malatya, Turkey. Electronic address: drumityolcu@hotmail.com. FAU - Acar, A H AU - Acar AH AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150805 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Postoperative Complications MH - Prospective Studies MH - *Surgical Flaps MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Wound Healing OTO - NOTNLM OT - impacted third molar OT - primary wound healing OT - triangular flap EDAT- 2015/08/10 06:00 MHDA- 2016/09/13 06:00 CRDT- 2015/08/10 06:00 PHST- 2014/12/16 00:00 [received] PHST- 2015/04/18 00:00 [revised] PHST- 2015/07/14 00:00 [accepted] PHST- 2015/08/10 06:00 [entrez] PHST- 2015/08/10 06:00 [pubmed] PHST- 2016/09/13 06:00 [medline] AID - S0901-5027(15)00266-0 [pii] AID - 10.1016/j.ijom.2015.07.007 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2015 Nov;44(11):1390-7. doi: 10.1016/j.ijom.2015.07.007. Epub 2015 Aug 5. PMID- 22751980 OWN - NLM STAT- MEDLINE DCOM- 20121211 LR - 20190709 IS - 1943-4723 (Electronic) IS - 0002-8177 (Linking) VI - 143 IP - 7 DP - 2012 Jul TI - The effects of combined oral anticoagulant-aspirin therapy in patients undergoing tooth extractions: a prospective study. PG - 771-6 AB - BACKGROUND: The authors conducted a study to evaluate the effect of combined oral anticoagulant-aspirin therapy on postoperative bleeding in patients undergoing tooth extractions. METHODS: A total of 213 patients were divided into three groups of 71 participants each. Patients in group A received combined anticoagulant-aspirin (100-milligram prophylactic dose) therapy. Patients in group B received oral anticoagulant therapy. Patients in group C received aspirin therapy (100-mg prophylactic dose). Bleeding was marked as an "event" if it met the following criteria: the bleeding continued beyond 12 hours, patient had to call the surgeon or return to dental practice or emergency department, bleeding resolved with large hematoma or ecchymosis within the oral soft tissues, or required a blood transfusion. RESULTS: Mean international normalized ratio (INR) (standard deviation) was 2.43 (0.61) in group A, and 2.45 (0.60) in group B. Postoperative bleeding occurred in three (4.2 percent) participants in group A, two (2.8 percent) participants in group B and no (0.0 percent) participants in group C. The authors found no statistical significance in postoperative bleeding between these three groups (χ(2) = 2.867, P = .238). All cases of hemorrhage were controlled easily by using local hemostatic measures. CONCLUSION: Tooth extractions can be performed safely while patients continue to receive combined anticoagulant-aspirin therapy. CLINICAL IMPLICATIONS: In patients receiving combined anticoagulant-aspirin therapy, simple tooth extractions can be performed safely without discontinuing either oral anticoagulant or antiplatelet therapy if their INRs are within therapeutic range and appropriate local hemostasis measures are provided. FAU - Bajkin, Branislav V AU - Bajkin BV AD - Department of Oral Surgery, Dental Clinic of Vojvodina, Faculty of Medicine Novi Sad, University of Novi Sad, Hajd uk Veljkova 12, 21000 Novi Sad, Serbia. inb@eunet.rs FAU - Bajkin, Ivana A AU - Bajkin IA FAU - Petrovic, Bojan B AU - Petrovic BB LA - eng PT - Controlled Clinical Trial PT - Journal Article PL - England TA - J Am Dent Assoc JT - Journal of the American Dental Association (1939) JID - 7503060 RN - 0 (Anticoagulants) RN - 0 (Drug Combinations) RN - 0 (Platelet Aggregation Inhibitors) RN - I6WP63U32H (Acenocoumarol) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Acenocoumarol/therapeutic use MH - Adult MH - Aged MH - Aged, 80 and over MH - Analysis of Variance MH - Anticoagulants/*therapeutic use MH - Aspirin/*therapeutic use MH - Chi-Square Distribution MH - *Dental Care for Chronically Ill MH - Drug Combinations MH - Female MH - Hemostatic Techniques MH - Humans MH - International Normalized Ratio MH - Male MH - Middle Aged MH - Oral Hemorrhage/etiology/therapy MH - Platelet Aggregation Inhibitors/*therapeutic use MH - Postoperative Hemorrhage/*etiology/therapy MH - Prospective Studies MH - *Tooth Extraction/adverse effects EDAT- 2012/07/04 06:00 MHDA- 2012/12/12 06:00 CRDT- 2012/07/04 06:00 PHST- 2012/07/04 06:00 [entrez] PHST- 2012/07/04 06:00 [pubmed] PHST- 2012/12/12 06:00 [medline] AID - S0002-8177(14)61123-5 [pii] AID - 10.14219/jada.archive.2012.0266 [doi] PST - ppublish SO - J Am Dent Assoc. 2012 Jul;143(7):771-6. doi: 10.14219/jada.archive.2012.0266. PMID- 8197031 OWN - NLM STAT- MEDLINE DCOM- 19940630 LR - 20201209 IS - 0277-0008 (Print) IS - 0277-0008 (Linking) VI - 14 IP - 2 DP - 1994 Mar-Apr TI - Evaluation of two opioid-acetaminophen combinations and placebo in postoperative oral surgery pain. PG - 139-46 AB - STUDY OBJECTIVE: To determine the relative analgesic potency and adverse effect liability of hydrocodone bitartrate 7.5 mg with acetaminophen 500 mg, codeine phosphate 30 mg with acetaminophen 300 mg, and placebo in the treatment of pain following oral surgery. DESIGN: Randomized, double-blind, single-dose, placebo-controlled, parallel-group study with self-ratings at 30 minutes and then at hourly intervals from hour 1 to hour 6. SETTING: Private, oral surgery practice sites. PATIENTS: Three hundred twenty-four outpatients with moderate or severe pain after the surgical removal of impacted third molars were selected. One was lost to follow-up and 32 did not need an analgesic; 232 patients had valid efficacy data. INTERVENTIONS: Patients were treated with a single oral dose of hydrocodone bitartrate 7.5 mg with acetaminophen 500 mg, codeine phosphate 30 mg with acetaminophen 300 mg, or placebo when they experienced steady, moderate or severe pain that, in their opinion, required an analgesic. Using a self-rating record, subjects rated their pain and its relief for 6 hours after medicating; estimates of peak and total analgesia were derived from these subjective reports. MEASUREMENTS AND MAIN RESULTS: This study was a valid analgesic assay. Both active treatments were significantly superior to placebo for all measures of analgesic efficacy. The hydrocodone-acetaminophen combination was significantly superior to the codeine-acetaminophen combination for total pain relief and the number of evaluations with 50% relief. Both active treatments manifested an analgesic effect within 30 minutes; the effect persisted for 5 hours for the codeine combination and 6 hours for the hydrocodone combination. Adverse effects were transient, consistent with the pharmacologic profiles of opioids, and none required treatment. CONCLUSIONS: A slight advantage in analgesic efficacy was demonstrated in this single-dose study for the hydrocodone-acetaminophen combination. Repeat-dose studies, however, should be conducted to determine the clinical significance of the difference in analgesic effect of these opioid combinations. FAU - Forbes, J A AU - Forbes JA AD - Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland. FAU - Bates, J A AU - Bates JA FAU - Edquist, I A AU - Edquist IA FAU - Burchfield, W H AU - Burchfield WH FAU - Smith, F G AU - Smith FG FAU - Schwartz, M K AU - Schwartz MK FAU - Kit, V AU - Kit V FAU - Hyatt, J AU - Hyatt J FAU - Bell, W E AU - Bell WE FAU - Beaver, W T AU - Beaver WT LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 362O9ITL9D (Acetaminophen) RN - 6YKS4Y3WQ7 (Hydrocodone) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/*therapeutic use MH - Adult MH - Codeine/*therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Hydrocodone/*therapeutic use MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction EDAT- 1994/03/01 00:00 MHDA- 1994/03/01 00:01 CRDT- 1994/03/01 00:00 PHST- 1994/03/01 00:00 [pubmed] PHST- 1994/03/01 00:01 [medline] PHST- 1994/03/01 00:00 [entrez] PST - ppublish SO - Pharmacotherapy. 1994 Mar-Apr;14(2):139-46. PMID- 20879647 OWN - NLM STAT- MEDLINE DCOM- 20101012 LR - 20151119 IS - 1029-4864 (Print) IS - 1029-4864 (Linking) VI - 65 IP - 6 DP - 2010 Jul TI - An alternative surgical flap design for impacted third molars: a comparison of two different surgical techniques. PG - 246, 248-51 AB - INTRODUCTION: A major concern of patients who need surgery for impacted third molars is the occurrence of pain and swelling. The damage done during the incision and retraction of soft tissue to expose the impacted teeth, contribute to the above-mentioned. AIMS AND OBJECTIVES: The study was done to prove a hypothesis that an alternative surgical flap (ASF) is effective in limiting pain and swelling when compared to the standard reverse L-flap (RLF). METHOD: A prospective randomized cross-over study was done, which included 33 healthy patients. Patients with mirror-image impacted mandibular third molars were selected. Evaluation of pain and swelling was done by Visual Analogue Scale (VAS), implemented for the first seven days after surgery. RESULTS: The results indicated on average that patients experience less pain with the ASF, although this was not statistically significant. The patients also indicated that they experienced a significant reduction (p < 0.05) in swelling for days one through three, compared to the RLF. CONCLUSIONS: The hypothesis that the ASF will result in less swelling, has been proven. It is therefore recommended that surgeons use this flap method for removal of impacted third molars to enhance post-operative patient comfort. FAU - Roode, G J AU - Roode GJ AD - Department of Maxillo-Facial- and Oral Surgery, Faculty of Health Sciences, University of Pretoria, P O Box 1266, Pretoria 0001, South Africa. giel.roode@up.ac.za FAU - Bütow, K AU - Bütow K LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - South Africa TA - SADJ JT - SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging JID - 9812497 SB - D MH - Adolescent MH - Adult MH - Cross-Over Studies MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Oral Surgical Procedures/*methods MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Prospective Studies MH - *Surgical Flaps MH - Surveys and Questionnaires MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2010/10/01 06:00 MHDA- 2010/10/13 06:00 CRDT- 2010/10/01 06:00 PHST- 2010/10/01 06:00 [entrez] PHST- 2010/10/01 06:00 [pubmed] PHST- 2010/10/13 06:00 [medline] PST - ppublish SO - SADJ. 2010 Jul;65(6):246, 248-51. PMID- 25638568 OWN - NLM STAT- MEDLINE DCOM- 20160721 LR - 20161125 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 53 IP - 4 DP - 2015 Apr TI - Efficacy of the technique of piezoelectric corticotomy for orthodontic traction of impacted mandibular third molars. PG - 326-31 LID - S0266-4356(15)00003-0 [pii] LID - 10.1016/j.bjoms.2015.01.002 [doi] AB - Our aim was to assess the efficacy of piezoelectric corticotomy for orthodontic traction of mandibular third molars close to the inferior alveolar nerve. Thirty patients with impacted third molars close to the nerve were included in the study, 15 of whom were treated with conventional orthodontic traction and 15 with piezoelectric corticotomy. We recorded duration of treatment including exposure and orthodontic traction, and time to the final extraction. Postoperative complications including trismus, swelling, and pain were also noted. Alveolar bone levels mesial and distal to the second molars were evaluated on cone-beam computed tomographic (CT) images. Student's t test was used to assess the significance of differences between the groups. After orthodontic treatments all impacted third molars were successfully removed from the inferior alveolar nerve without neurological damage. The mean (SD) duration of surgical exposure in the piezoelectric corticotomy group was significantly longer than that in the conventional group (p=0.01). The mean (SD) duration of traction was 4 (2.3) months after piezoelectric corticotomy, much shorter than the 7.5 (1.3) months in the conventional group (p=0.03). There were no significant differences in postoperative complications between the groups. There was a significant increase in the distal alveolar height of second molars after treatment in both groups (p<0.01). We conclude that the use of piezoelectric corticotomy allows more efficient and faster traction of third molars with a close relation between the root and the inferior alveolar nerve, although it took longer than the traditional technique. CI - Copyright © 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Ma, Zhigui AU - Ma Z AD - Department of Oral Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China. FAU - Xu, Guangzhou AU - Xu G AD - Department of Oral Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China. Electronic address: xgzmy@163.com. FAU - Yang, Chi AU - Yang C AD - Department of Oral Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China. Electronic address: yangchi63@hotmail.com. FAU - Xie, Qianyang AU - Xie Q AD - Department of Oral Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China. FAU - Shen, Yuqing AU - Shen Y AD - Department of Oral Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China. FAU - Zhang, Shanyong AU - Zhang S AD - Department of Oral Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150128 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Adult MH - Alveolar Process/diagnostic imaging MH - Cone-Beam Computed Tomography/methods MH - Edema/etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/diagnostic imaging/*surgery MH - Mandibular Nerve/diagnostic imaging MH - Molar/diagnostic imaging MH - Molar, Third/diagnostic imaging/*surgery MH - Orthodontic Extrusion/*methods MH - Osteotomy/*methods MH - Pain, Postoperative/etiology MH - Piezosurgery/*methods MH - Postoperative Complications MH - Radiography, Panoramic/methods MH - Tooth Root/diagnostic imaging MH - Tooth, Impacted/diagnostic imaging/*surgery MH - Treatment Outcome MH - Trismus/etiology MH - Young Adult OTO - NOTNLM OT - Bone formation OT - Cone-beam CT OT - Impacted third molar OT - Orthodontic traction OT - Piezoelectric corticotomy EDAT- 2015/02/02 06:00 MHDA- 2016/07/22 06:00 CRDT- 2015/02/02 06:00 PHST- 2014/05/06 00:00 [received] PHST- 2015/01/02 00:00 [accepted] PHST- 2015/02/02 06:00 [entrez] PHST- 2015/02/02 06:00 [pubmed] PHST- 2016/07/22 06:00 [medline] AID - S0266-4356(15)00003-0 [pii] AID - 10.1016/j.bjoms.2015.01.002 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2015 Apr;53(4):326-31. doi: 10.1016/j.bjoms.2015.01.002. Epub 2015 Jan 28. PMID- 33561426 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 79 IP - 5 DP - 2021 May TI - Anti-Inflammatory Effectiveness of Oral Dexamethasone 4 mg on Mandibular Third Molar Surgeries: A Split-Mouth Randomized Clinical Trial. PG - 981-988 LID - S0278-2391(21)00003-3 [pii] LID - 10.1016/j.joms.2021.01.003 [doi] AB - PURPOSE: This study aimed to evaluate the anti-inflammatory effect of oral dexamethasone 4 mg in a single dose preemptively administered to reduce pain, swelling, and trismus following mandibular third molar surgeries. METHODS: A split-mouth randomized clinical trial was performed including 22 participants undergoing surgical removal of bilateral and symmetrically positioned third molars. A total of 44 teeth were allocated by simple randomization to either the test or nonintervention/control side. Oral dexamethasone 4 mg was administered on the test side an hour before the surgery. All of the participants were unaware of the medication studied, and only 1 surgeon, blinded to the medication intake, performed all of the procedures. Anti-inflammatory effect was evaluated using the clinical parameters of mouth opening, swelling, and rescue analgesic medication intake to control pain. The statistical analysis was blinded to the allocation groups, and a significance value P < .05 was adopted for all the tests. RESULTS: Dexamethasone reduced the mean of rescue analgesic medication intake by 5 times (P = .002). Facial swelling was lower on the test side by 72h postsurgery in comparison with the control side (P = .036). No significant difference in mouth opening was found between the groups. CONCLUSIONS: Preemptive use of oral dexamethasone 4 mg proved to be effective in controlling pain and reducing the need for rescue medication and had a beneficial effect in reducing swelling during a short postoperative period. CI - Copyright © 2021 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Oliveira, Eulália Mendes de AU - Oliveira EM AD - Graduate Student, Graduate Program in Dentistry, Faculty of Pharmacy, Dentistry, and Nursing. Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address: eulaliamoliveira@alu.ufc.br. FAU - Oliveira, Victor Bento AU - Oliveira VB AD - Graduate Student, Graduate Program in Dentistry, Faculty of Pharmacy, Dentistry, and Nursing. Federal University of Ceará, Fortaleza, CE, Brazil. FAU - Araújo, Lana Karine AU - Araújo LK AD - Graduate Student, Graduate Program in Biotechnology, School of Medicine at Sobral, Federal University of Ceará, Sobral, CE, Brazil. FAU - Lopes, Timóteo Sousa AU - Lopes TS AD - Graduate Student, Graduate Program in Health Sciences, School of Medicine at Sobral, Federal University of Ceará, Sobral, CE, Brazil. FAU - Rego, Rodrigo Otavio AU - Rego RO AD - Associate Professor, Department of Dentistry, School of Dentistry at Sobral, Federal University of Ceará, Sobral, CE, Brazil. FAU - Sampieri, Marcelo Bonifácio da Silva AU - Sampieri MBDS AD - Assistant Professor, Department of Dentistry, School of Dentistry at Sobral, Federal University of Ceará, Sobral, CE, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20210112 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents) RN - 7S5I7G3JQL (Dexamethasone) SB - AIM SB - D SB - IM MH - Anti-Inflammatory Agents/therapeutic use MH - Dexamethasone/therapeutic use MH - Edema/drug therapy/prevention & control MH - Humans MH - *Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/drug therapy/prevention & control MH - Tooth Extraction MH - *Tooth, Impacted MH - Trismus/drug therapy/etiology/prevention & control EDAT- 2021/02/10 06:00 MHDA- 2021/05/15 06:00 CRDT- 2021/02/09 20:09 PHST- 2020/09/16 00:00 [received] PHST- 2020/12/17 00:00 [revised] PHST- 2021/01/03 00:00 [accepted] PHST- 2021/02/10 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2021/02/09 20:09 [entrez] AID - S0278-2391(21)00003-3 [pii] AID - 10.1016/j.joms.2021.01.003 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2021 May;79(5):981-988. doi: 10.1016/j.joms.2021.01.003. Epub 2021 Jan 12. PMID- 19375008 OWN - NLM STAT- MEDLINE DCOM- 20090518 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 67 IP - 5 DP - 2009 May TI - Randomized, prospective trial comparing bridging therapy using low-molecular-weight heparin with maintenance of oral anticoagulation during extraction of teeth. PG - 990-5 LID - 10.1016/j.joms.2008.12.027 [doi] AB - PURPOSE: To evaluate postoperative bleeding and thromboembolic complications during dental extractions in anticoagulated patients, using 2 different protocols. PATIENTS AND METHODS: In total, 214 anticoagulated patients in need of simple dental extractions were randomized into 2 groups. Group A consisted of 109 patients on continuous oral anticoagulation therapy (OAT), with a mean international normalized ratio (INR) of 2.45 +/- 0.54. Local hemostasis in these patients was achieved with resorbable collagen sponges, without wound suturing. Group B consisted of 105 patients on bridging therapy with low-molecular-weight heparin (nadroparin-calcium), with a mean INR of 1.26 +/- 0.11 on the day of the procedure. Neither local hemostatic agents nor suturing of the wound was used in these patients. RESULTS: Eight (7.34%) patients in group A and 5 (4.76%) patients in group B manifested postextractional bleeding, without statistical significance (chi(2), Yates' = 0.253, P > .05). All cases of hemorrhage were mild and easily controlled using local hemostatic measures. None of the participants in either group experienced thromboembolic complications. CONCLUSIONS: In patients receiving OAT with an INR 0.0625 microgram.kg-1 min-1). Anesthesia was maintained with Desflurane (group D, n = 31) (end-tidal concentration 4-6%) or Propofol (group P, n = 32) (initial infusion TCI 8 micrograms.ml-1 reduced to 2-3 micrograms.ml-1 after intubation). Corticosteroids, a non-steroidal anti-inflammatory drug (NSAID) (Diclofenac) and a partial mu agonist drug (Tramadol) were administered i.v. during the procedure to prevent early postoperative pain. Recovery time, postoperative pain, recovery of cognition and nausea or vomiting were also evaluated during the first six postoperative hours. Overall mean systolic blood pressures and heart rate were similar in the two groups during surgery. Mean times to extubation and to recall of birth-date and room number were also similar. The quality of awakening was good in the two groups. Most patients complained of moderate pain or had no pain during the first six postoperative hours. The incidence of nausea and vomiting was similar in both groups. No other side effect was observed. These data suggest that the association of Remifentanil, Methylprednisolone, Diclofenac and Tramadol is an useful technique in ambulatory oral surgery in two comparable anesthetic regimens. FAU - Pendeville, P E AU - Pendeville PE AD - Department of Anesthesiology, UCL Medical School, Saint-Luc Hospital, Brussels, Belgium. FAU - Kabongo, F AU - Kabongo F FAU - Veyckemans, F AU - Veyckemans F LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Belgium TA - Acta Anaesthesiol Belg JT - Acta anaesthesiologica Belgica JID - 0421022 RN - 0 (Anesthetics, Combined) RN - 0 (Anesthetics, Inhalation) RN - 0 (Anesthetics, Intravenous) RN - 0 (Piperidines) RN - CRS35BZ94Q (Desflurane) RN - CYS9AKD70P (Isoflurane) RN - P10582JYYK (Remifentanil) RN - X4W7ZR7023 (Methylprednisolone) RN - YI7VU623SF (Propofol) SB - IM MH - Adolescent MH - *Ambulatory Surgical Procedures MH - Anesthesia Recovery Period MH - *Anesthesia, Dental MH - *Anesthetics, Combined MH - *Anesthetics, Inhalation MH - *Anesthetics, Intravenous MH - Desflurane MH - Female MH - Humans MH - *Isoflurane/analogs & derivatives MH - Male MH - Methylprednisolone MH - Molar, Third/surgery MH - Pain, Postoperative/prevention & control MH - *Piperidines MH - *Propofol MH - Prospective Studies MH - Remifentanil MH - *Tooth Extraction MH - Tooth, Impacted EDAT- 2001/09/06 10:00 MHDA- 2002/01/23 10:01 CRDT- 2001/09/06 10:00 PHST- 2001/09/06 10:00 [pubmed] PHST- 2002/01/23 10:01 [medline] PHST- 2001/09/06 10:00 [entrez] PST - ppublish SO - Acta Anaesthesiol Belg. 2001;52(2):181-6. PMID- 21519882 OWN - NLM STAT- MEDLINE DCOM- 20121022 LR - 20181113 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 16 IP - 3 DP - 2012 Jun TI - Necessity of 3D visualization for the removal of lower wisdom teeth: required sample size to prove non-inferiority of panoramic radiography compared to CBCT. PG - 699-706 LID - 10.1007/s00784-011-0553-8 [doi] AB - The availability of cone beam computed tomography (CBCT) and the numbers of CBCT scans rise constantly, increasing the radiation burden to the patient. A growing discussion is noticeable if a CBCT scan prior to the surgical removal of wisdom teeth may be indicated. We aimed to confirm non-inferiority with respect to damage of the inferior alveolar nerve in patients diagnosed by panoramic radiography compared to CBCT in a prospective randomized controlled multicentre trial. Sample size (number of required third molar removals) was calculated for the study and control groups as 183,474 comparing temporary and 649,036 comparing permanent neurosensory disturbances of the inferior alveolar nerve. Modifying parameter values resulted in sample sizes ranging from 39,584 to 245,724 respectively 140,024 to 869,250. To conduct a clinical study to prove a potential benefit from CBCT scans prior to surgical removal of lower wisdom teeth with respect to the most important parameter, i.e., nerval damage, is almost impossible due to the very large sample sizes required. This fact vice versa indicates that CBCT scans should only be performed in high risk wisdom tooth removals. FAU - Roeder, Felix AU - Roeder F AD - Department of Oral Surgery (and Oral Radiology), University Medical Center of the Johannes-Gutenberg-University Mainz, Dental School, Augustusplatz 2, 55131 Mainz, Germany. roederfe@uni-mainz.de FAU - Wachtlin, Daniel AU - Wachtlin D FAU - Schulze, Ralf AU - Schulze R LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20110426 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - D MH - *Cone-Beam Computed Tomography MH - Feasibility Studies MH - Humans MH - *Imaging, Three-Dimensional MH - Mandible/*diagnostic imaging MH - Mandibular Nerve MH - Molar, Third/diagnostic imaging/*surgery MH - Prospective Studies MH - *Radiography, Panoramic MH - Sample Size MH - *Tooth Extraction MH - Trigeminal Nerve Injuries/*prevention & control EDAT- 2011/04/27 06:00 MHDA- 2012/10/23 06:00 CRDT- 2011/04/27 06:00 PHST- 2011/01/23 00:00 [received] PHST- 2011/04/11 00:00 [accepted] PHST- 2011/04/27 06:00 [entrez] PHST- 2011/04/27 06:00 [pubmed] PHST- 2012/10/23 06:00 [medline] AID - 10.1007/s00784-011-0553-8 [doi] PST - ppublish SO - Clin Oral Investig. 2012 Jun;16(3):699-706. doi: 10.1007/s00784-011-0553-8. Epub 2011 Apr 26. PMID- 3928508 OWN - NLM STAT- MEDLINE DCOM- 19851022 LR - 20191030 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 14 IP - 4 DP - 1985 Aug TI - Voltaren as an analgesic after surgical removal of a lower wisdom tooth. PG - 333-8 AB - In a controlled trial, before having a lower wisdom tooth surgically removed, 190 patients were blindly randomized to 2 parallel groups. One group received 100 mg Voltaren (diclofenac-sodium) before surgery and then 50 mg 3 times a day for 5 days; the other group in Sweden widely used fixed combination tablets (acetylsalicylic acid 500 mg, caffeine 50 mg, aprobarbital 20 mg, codeine phosphate 10 mg) in the highest recommended dose, 2 tablets when needed at most 3 times a day. Twice a day the patients recorded pain and swelling on 100 mm visual analogue scales. Patients treated with Voltaren had significantly less pain and swelling (p less than 0.001). Furthermore, they had significantly fewer days away from work (p less than 0.01). The study indicates that visual analogue scales may also be useful in assessment of swelling and that Voltaren in a fixed dosage offers a promising alternative against postoperative pain and swelling. FAU - Henrikson, P A AU - Henrikson PA FAU - Thilander, H AU - Thilander H FAU - Wåhlander, L A AU - Wåhlander LA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Phenylacetates) RN - 144O8QL0L1 (Diclofenac) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Edema/drug therapy/etiology/physiopathology MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy/physiopathology MH - Patient Compliance MH - Phenylacetates/*therapeutic use MH - Random Allocation MH - Tooth Extraction/adverse effects EDAT- 1985/08/01 00:00 MHDA- 1985/08/01 00:01 CRDT- 1985/08/01 00:00 PHST- 1985/08/01 00:00 [pubmed] PHST- 1985/08/01 00:01 [medline] PHST- 1985/08/01 00:00 [entrez] AID - 10.1016/s0300-9785(85)80022-3 [doi] PST - ppublish SO - Int J Oral Surg. 1985 Aug;14(4):333-8. doi: 10.1016/s0300-9785(85)80022-3. PMID- 3457335 OWN - NLM STAT- MEDLINE DCOM- 19860429 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 61 IP - 2 DP - 1986 Feb TI - The effect of methylprednisolone on pain, trismus, and swelling after removal of third molars. PG - 134-8 AB - Thirty-one healthy patients whose third molars needed to be removed were randomly placed into two groups. Before sedation the control group (n = 16) received normal saline solution and the experimental group (n = 15) received 125 mg of methylprednisolone intravenously. Swelling was measured by photographic and face-bow techniques, trismus was determined by measuring maximal interincisal opening, and pain was evaluated by asking the patients to report the number of pain pills they used and assess th severity of their pain daily. The swelling and pain, but not the trismus, that developed after third molar removal were significantly reduced by a single dose of methylprednisolone. FAU - Beirne, O R AU - Beirne OR FAU - Hollander, B AU - Hollander B LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adolescent MH - Adult MH - Edema/physiopathology/*prevention & control MH - Female MH - Humans MH - Male MH - Methylprednisolone/pharmacology/*therapeutic use MH - Molar, Third/*surgery MH - Pain, Postoperative/physiopathology/*prevention & control MH - Random Allocation MH - Time Factors MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/physiopathology/surgery MH - Trismus/physiopathology/*prevention & control EDAT- 1986/02/01 00:00 MHDA- 1986/02/01 00:01 CRDT- 1986/02/01 00:00 PHST- 1986/02/01 00:00 [pubmed] PHST- 1986/02/01 00:01 [medline] PHST- 1986/02/01 00:00 [entrez] AID - 10.1016/0030-4220(86)90173-8 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1986 Feb;61(2):134-8. doi: 10.1016/0030-4220(86)90173-8. PMID- 2941056 OWN - NLM STAT- MEDLINE DCOM- 19860820 LR - 20201209 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 24 IP - 2 DP - 1986 Apr TI - A double-blind placebo-controlled comparison of three ibuprofen/codeine combinations and aspirin. PG - 122-9 AB - In a double-blind, single dose study of analgesic efficacy, 165 patients who were expected to develop moderate to severe pain following the removal of an impacted mandibular third molar tooth were allocated to receive aspirin, placebo, or an increasing dose of a fixed ratio ibuprofen/codeine combination. The degree of pain experienced prior to medication was noted and the patients were asked to record the degree of pain and of pain relief hourly for the following 5 hours. The study produced clear evidence of the superior efficacy of the combinations when compared to placebo and aspirin. In addition, the high dose combination appeared to be superior with respect to pain relief and the need for additional analgesia compared to the low dose treatment. There were few side effects and only one severe reaction was reported by a patient in the high dose group. To avoid side effects it is suggested that the medium-dose combination, ibuprofen 400 mg/codeine 30 mg, is optimal. FAU - Frame, J W AU - Frame JW FAU - Fisher, S E AU - Fisher SE FAU - Pickvance, N J AU - Pickvance NJ FAU - Skene, A M AU - Skene AM LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Drug Combinations) RN - R16CO5Y76E (Aspirin) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Aspirin/*therapeutic use MH - Clinical Trials as Topic MH - Codeine/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Humans MH - Ibuprofen/administration & dosage/*therapeutic use MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Random Allocation MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1986/04/01 00:00 MHDA- 1986/04/01 00:01 CRDT- 1986/04/01 00:00 PHST- 1986/04/01 00:00 [pubmed] PHST- 1986/04/01 00:01 [medline] PHST- 1986/04/01 00:00 [entrez] AID - 10.1016/0266-4356(86)90007-0 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1986 Apr;24(2):122-9. doi: 10.1016/0266-4356(86)90007-0. PMID- 3117914 OWN - NLM STAT- MEDLINE DCOM- 19871203 LR - 20201209 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 16 IP - 4 DP - 1987 Aug TI - Ibuprofen given pre- and post-operatively for the relief of pain. PG - 420-4 AB - 155 patients undergoing surgical removal of lower third molars took part in a parallel group, randomised double-blind study to assess the analgesic effect of single pre-operative doses of ibuprofen (400 mg), codeine phosphate (30 mg), a combination of ibuprofen/codeine (400 mg/30 mg), placebo and post-operative single doses of the same combination or diflunisal (250 mg). Patients receiving the combination or ibuprofen pre-operatively took significantly longer between surgery completion and needing the post-operative study treatment than patients receiving codeine phosphate or placebo. At 1 1/2-2 h after post-operative administration, patients receiving the combination post-operatively reported significantly greater decreases in pain severity than those receiving diflunisal. Patients taking the combination post-operatively experienced significantly better pain relief than patients taking diflunisal at 1 and 2 h, but the reverse was true at 5 h. Side-effects reported were mild with no significant differences between the different treatment groups. FAU - Hill, C M AU - Hill CM AD - Department of Dental Surgery, School of Dentistry, University of Leeds, UK. FAU - Carroll, M J AU - Carroll MJ FAU - Giles, A D AU - Giles AD FAU - Pickvance, N AU - Pickvance N LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Drug Combinations) RN - 7C546U4DEN (Diflunisal) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Clinical Trials as Topic MH - Codeine/*administration & dosage MH - Diflunisal/therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/*administration & dosage MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain, Postoperative/*prevention & control MH - *Premedication MH - Tooth Extraction/*adverse effects EDAT- 1987/08/01 00:00 MHDA- 1987/08/01 00:01 CRDT- 1987/08/01 00:00 PHST- 1987/08/01 00:00 [pubmed] PHST- 1987/08/01 00:01 [medline] PHST- 1987/08/01 00:00 [entrez] AID - 10.1016/s0901-5027(87)80078-4 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1987 Aug;16(4):420-4. doi: 10.1016/s0901-5027(87)80078-4. PMID- 10211012 OWN - NLM STAT- MEDLINE DCOM- 19990427 LR - 20201209 IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 81 IP - 6 DP - 1998 Dec TI - Tenoxicam and paracetamol-codeine combination after oral surgery: a prospective, randomized, double-blind, placebo-controlled study. PG - 875-80 AB - We studied 90 adults undergoing surgical removal of at least both lower third molar teeth as day cases under standardized general anaesthesia. Patients were allocated randomly (with stratification for surgeon) to receive tenoxicam 40 mg, tenoxicam 20 mg or placebo i.v. at induction of anaesthesia and orally (effervescent tablets) with food on each of the subsequent 2 days. Panadeine (paracetamol 500 mg-codeine 8 mg) was given before operation and was available as needed for pain thereafter, to a limit of two tablets every 4 h. Nefopam i.v. was also available. Efficacy variables and adverse reactions were assessed over 6 days. Over the 6-day period, patients who received tenoxicam reported less pain on rest (area under the curve; P < 0.05) and less disturbance in sleep (P < 0.01) even though they used fewer Panadeine tablets (P < 0.05). Differences between tenoxicam 40 mg and 20 mg were not significant. There was no significant difference in nefopam requirements or side effects, and no adverse event attributable to the study medication. FAU - Merry, A F AU - Merry AF AD - St Marks Clinic, Auckland, New Zealand. FAU - Swinburn, P F AU - Swinburn PF FAU - Middleton, N G AU - Middleton NG FAU - Edwards, J L AU - Edwards JL FAU - Calder, M V AU - Calder MV LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase Inhibitors) RN - 13T4O6VMAM (Piroxicam) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) RN - Z1R9N0A399 (tenoxicam) SB - IM MH - Acetaminophen MH - Adolescent MH - Adult MH - Analgesia/*methods MH - Analgesics/therapeutic use MH - *Anti-Inflammatory Agents, Non-Steroidal MH - Codeine/therapeutic use MH - Cyclooxygenase Inhibitors/*therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*analogs & derivatives MH - Prospective Studies MH - *Tooth Extraction EDAT- 1999/04/22 00:00 MHDA- 1999/04/22 00:01 CRDT- 1999/04/22 00:00 PHST- 1999/04/22 00:00 [pubmed] PHST- 1999/04/22 00:01 [medline] PHST- 1999/04/22 00:00 [entrez] AID - S0007-0912(17)39461-8 [pii] AID - 10.1093/bja/81.6.875 [doi] PST - ppublish SO - Br J Anaesth. 1998 Dec;81(6):875-80. doi: 10.1093/bja/81.6.875. PMID- 17683324 OWN - NLM STAT- MEDLINE DCOM- 20071018 LR - 20161020 IS - 0960-7439 (Print) IS - 0960-7439 (Linking) VI - 17 IP - 5 DP - 2007 Sep TI - Assessment of early postoperative pain and haemorrhage in young children undergoing dental extractions under general anaesthesia. PG - 352-7 AB - BACKGROUND: There have been a lot of guidelines issued about dental extractions under general anaesthesia. There is a considerable body of research about the use of local anaesthetic as an adjunct. Some of this research appears to be contradictory about the use of local anaesthetic in addition to general anaesthesia in very young children. This study attempts to clarify the issue. AIM: To determine whether postoperative pain/distress in the early recovery period was different for those children who did or did not have local infiltration anaesthesia for extractions under general anaesthetic, and whether the incidence of clinically significant postoperative bleeding was different for the two groups. DESIGN: Children aged 2-6 years, admitted for extraction of deciduous posterior teeth under general anaesthetic, were randomized to groups that were or were not given local infiltration anaesthesia during the procedure. The children were premedicated with paracetamol and ibuprofen, and had absorbable haemostatic packs inserted during the operation. Staff blinded to treatment allocation made observations in the recovery period of pain and any interventions for bleeding. RESULTS: There was no difference in postoperative pain, as measured using CHEOPS scale between the two groups, but an increase in post operative bleeding in the group who did not have local anaesthetic administered 5/38 compared to 0/38, P = 0.02. CONCLUSIONS: As use of local anaesthetic reduces bleeding without altering pain or distress in young children undergoing posterior deciduous tooth extraction, we should consider using as an adjunct to general anaesthesia. FAU - McWilliams, Penelope A AU - McWilliams PA AD - NHS Dumfries & Galloway, Logan East, Dumfries, UK. p.mcwilliams@nhs.net FAU - Rutherford, John S AU - Rutherford JS LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Int J Paediatr Dent JT - International journal of paediatric dentistry JID - 9107511 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Hemostatics) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - D MH - Acetaminophen/therapeutic use MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthesia Recovery Period MH - *Anesthesia, Dental MH - *Anesthesia, General MH - Anesthesia, Local MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Child MH - Child, Preschool MH - Hemostatics/therapeutic use MH - Humans MH - Ibuprofen/therapeutic use MH - Pain, Postoperative/*etiology MH - Postoperative Hemorrhage/*etiology MH - Preanesthetic Medication MH - Single-Blind Method MH - Stress, Psychological/etiology MH - *Tooth Extraction MH - Tooth, Deciduous/surgery EDAT- 2007/08/09 09:00 MHDA- 2007/10/19 09:00 CRDT- 2007/08/09 09:00 PHST- 2007/08/09 09:00 [pubmed] PHST- 2007/10/19 09:00 [medline] PHST- 2007/08/09 09:00 [entrez] AID - IPD841 [pii] AID - 10.1111/j.1365-263X.2007.00841.x [doi] PST - ppublish SO - Int J Paediatr Dent. 2007 Sep;17(5):352-7. doi: 10.1111/j.1365-263X.2007.00841.x. PMID- 22446069 OWN - NLM STAT- MEDLINE DCOM- 20130527 LR - 20120716 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 41 IP - 8 DP - 2012 Aug TI - Can a single pain rating replace a multiple pain rating in third molar surgery studies? Analysis of 220 patients. PG - 1010-3 LID - 10.1016/j.ijom.2012.02.016 [doi] AB - This study describes the comparison of multiple and single pain ratings in patients after surgical removal of the third molar. Correlation and agreement analysis were performed between the average pain intensity measured three times a day over a period of 7 days and one single pain rating (designated the 'recalled average' pain, as assessed by the patient) after surgical removal of the lower third molar. The study population consisted of patients participating in three randomized trials. The results show that both measurement correlated good to excellent, but there was a large variation in agreement between the ratings. In conclusion, in patients with surgical third molar removal a single pain rating is not an accurate predictor of the average pain measured by a multiple pain-rating test. A single pain rating cannot replace a multiple pain assessment. CI - Copyright © 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Martin, W J J M AU - Martin WJ AD - Department of Oral and Maxillofacial Surgery/Oral Pathology, Vrije Universiteit Medical Center/Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. FAU - Heymans, M W AU - Heymans MW FAU - Skorpil, N E AU - Skorpil NE FAU - Forouzanfar, T AU - Forouzanfar T LA - eng PT - Comparative Study PT - Journal Article DEP - 20120324 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement/*methods/statistics & numerical data MH - Pain, Postoperative/classification MH - Randomized Controlled Trials as Topic MH - Self Report MH - Tooth Extraction MH - Young Adult EDAT- 2012/03/27 06:00 MHDA- 2013/05/29 06:00 CRDT- 2012/03/27 06:00 PHST- 2010/11/23 00:00 [received] PHST- 2011/12/29 00:00 [revised] PHST- 2012/02/20 00:00 [accepted] PHST- 2012/03/27 06:00 [entrez] PHST- 2012/03/27 06:00 [pubmed] PHST- 2013/05/29 06:00 [medline] AID - S0901-5027(12)00084-7 [pii] AID - 10.1016/j.ijom.2012.02.016 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2012 Aug;41(8):1010-3. doi: 10.1016/j.ijom.2012.02.016. Epub 2012 Mar 24. PMID- 267314 OWN - NLM STAT- MEDLINE DCOM- 19770812 LR - 20161020 IS - 0036-7702 (Print) IS - 0036-7702 (Linking) VI - 87 IP - 5 DP - 1977 May TI - [Comparative clinical and histological studies on extraction wounds with and without local application of a salicylic acid preparation (Apernyl)]. PG - 381-94 AB - Selected patients with extraction wounds served to experiment with Apernyl-styli of Bayer. Contralateral alveoli were used as controls. 10 days following operation biopsies were taken from treated and untreated alveoli. Histologically, a morphometric study was made, and clinically healing was judged by the frequency of complications and the initial physiologic pain. The results show that Apernyl does not influence histological healing, positively or negatively. Thus, the results obtained by Nordenram and Band (1970) and Satoh et al. (1973) could be confirmed. Clinically, there were significanlty less p.o. complications in patients with Apernyl prophylaxis; 2 of 51 treated alveoli compared to 8 of 45 untreated ones. Pain was significantly reduced: 17 of the 19 patients complained of pain in the untreated half of the jaw, while only 4 suffered pain on the treated side. This confirms the findings of Neuner and Panzera and Neuner and Schegg (1972 and 1969 resp.). FAU - Kallenberger, A AU - Kallenberger A FAU - Marxer, M AU - Marxer M LA - ger PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - English Abstract PT - Journal Article TT - Vergleichende klinische und histologische Untersuchungen an Extraktionswunden mit und ohne lokale Applikation eines Salicylsäurepräparates (Apernyl). PL - Switzerland TA - SSO Schweiz Monatsschr Zahnheilkd JT - Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie JID - 20520010R RN - 0 (Salicylates) SB - D SB - IM MH - Alveolar Process/pathology MH - Blood Coagulation/drug effects MH - Drug Evaluation MH - Dry Socket/prevention & control MH - Granulation Tissue/drug effects MH - Humans MH - Osteogenesis/drug effects MH - Pain/drug therapy MH - Salicylates/*therapeutic use MH - Tooth Extraction MH - *Wound Healing/drug effects EDAT- 1977/05/01 00:00 MHDA- 1977/05/01 00:01 CRDT- 1977/05/01 00:00 PHST- 1977/05/01 00:00 [pubmed] PHST- 1977/05/01 00:01 [medline] PHST- 1977/05/01 00:00 [entrez] PST - ppublish SO - SSO Schweiz Monatsschr Zahnheilkd. 1977 May;87(5):381-94. PMID- 3556263 OWN - NLM STAT- MEDLINE DCOM- 19870716 LR - 20201209 IS - 0300-0605 (Print) IS - 0300-0605 (Linking) VI - 15 IP - 2 DP - 1987 Mar-Apr TI - Analgesic efficacy and side-effect profile of paracetamol/codeine and paracetamol/dextropropoxyphene after surgical removal of a lower wisdom tooth. PG - 83-8 AB - A double-blind randomized analgesic trial was carried out on 180 patients undergoing surgical removal of an impacted lower wisdom tooth. The patients took their first dose of either 1000 mg paracetamol plus 60 mg codeine or 650 mg paracetamol plus 65 mg dextropropoxyphene when pain appeared after the decline of the local anaesthesia. If needed, another two doses were available during the observation period (less than or equal to 10 h). The analgesic efficacy of paracetamol/codeine was overall superior to paracetamol/dextropropoxyphene in all variables. Sufficient pain relief was obtained in most patients. The pain reduction after the first dose was 64% in the group receiving paracetamol/codeine compared with 53% in the group receiving paracetamol/dextropropoxyphene and the mean durations of effect of the first dose were 6.6 and 5.8 h, respectively. Side-effects appeared in all patient groups but were most frequent in women taking paracetamol/codeine. FAU - Sagne, S AU - Sagne S FAU - Henrikson, P A AU - Henrikson PA FAU - Kahnberg, K E AU - Kahnberg KE FAU - Thilander, H AU - Thilander H FAU - Bertilson, S O AU - Bertilson SO LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Int Med Res JT - The Journal of international medical research JID - 0346411 RN - 0 (Drug Combinations) RN - 0 (acetaminophen, codeine drug combination) RN - 362O9ITL9D (Acetaminophen) RN - 39400-85-6 (acetaminophen, dextropropoxyphene, drug combination) RN - S2F83W92TK (Dextropropoxyphene) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/adverse effects/*therapeutic use MH - Adult MH - Clinical Trials as Topic MH - Codeine/adverse effects/*therapeutic use MH - Dextropropoxyphene/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations/adverse effects/therapeutic use MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/diagnosis/*drug therapy MH - Random Allocation MH - Tooth Extraction/*adverse effects EDAT- 1987/03/01 00:00 MHDA- 1987/03/01 00:01 CRDT- 1987/03/01 00:00 PHST- 1987/03/01 00:00 [pubmed] PHST- 1987/03/01 00:01 [medline] PHST- 1987/03/01 00:00 [entrez] AID - 10.1177/030006058701500204 [doi] PST - ppublish SO - J Int Med Res. 1987 Mar-Apr;15(2):83-8. doi: 10.1177/030006058701500204. PMID- 2119796 OWN - NLM STAT- MEDLINE DCOM- 19901121 LR - 20190912 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 28 IP - 4 DP - 1990 Aug TI - Inhibition of tissue prostaglandin synthesis during third molar surgery: use of preoperative fenbufen. PG - 251-3 AB - Preoperative administration of a non-steroidal anti-inflammatory drug (fenbufen) reduced immediate postoperative pain in a group of 38 patients undergoing removal of mandibular third molars, compared to placebo. However, overall pain experience and morbidity were not significantly improved suggesting that there was no clinical benefit derived from interference with tissue prostaglandin synthesis at the time of surgery. FAU - Smith, A C AU - Smith AC AD - Department of Oral and Maxillofacial Surgery, Nottingham General Hospital. FAU - Brook, I M AU - Brook IM LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase Inhibitors) RN - 0 (Phenylbutyrates) RN - 0 (Placebos) RN - 0 (Prostaglandin Antagonists) RN - 9815R1WR9B (fenbufen) SB - D SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - *Cyclooxygenase Inhibitors MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Phenylbutyrates/*therapeutic use MH - Placebos MH - *Premedication MH - Prostaglandin Antagonists/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1990/08/01 00:00 MHDA- 1990/08/01 00:01 CRDT- 1990/08/01 00:00 PHST- 1990/08/01 00:00 [pubmed] PHST- 1990/08/01 00:01 [medline] PHST- 1990/08/01 00:00 [entrez] AID - 10.1016/0266-4356(90)90061-o [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1990 Aug;28(4):251-3. doi: 10.1016/0266-4356(90)90061-o. PMID- 17188409 OWN - NLM STAT- MEDLINE DCOM- 20080310 LR - 20181201 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 46 IP - 2 DP - 2008 Mar TI - Routine antibiotic prophylaxis is not necessary during operations to remove third molars. PG - 133-5 AB - The purpose of this study was to evaluate the efficacy of antibiotic prophylaxis during removal of impacted third molars. We studied 150 patients with impacted mandibular or maxillary third molars who were divided randomly into three groups. The first was given amoxicillin 2g combined with clavulanic acid, orally daily for 5 days postoperatively; starting at the end of the operation. The second group was given the same drugs but the regimen started 5 days before the operation. The third was given no antibiotics. Pain, infection, swelling, alveolar osteitis, and interincisal mouth opening (mm) were evaluated. There were no significant differences among the groups in the incidence of these complications. We cannot recommend routine oral antibiotic prophylaxis in third molar surgery. FAU - Ataoğlu, Hanife AU - Ataoğlu H AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Selçuk, Konya, Turkiye. hataoglu@selcuk.edu.tr FAU - Oz, Gülsün Yildirim AU - Oz GY FAU - Candirli, Celal AU - Candirli C FAU - Kiziloğlu, Dilek AU - Kiziloğlu D LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20061222 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anti-Bacterial Agents) RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) SB - D SB - IM MH - Adult MH - Amoxicillin-Potassium Clavulanate Combination/administration & dosage MH - Anti-Bacterial Agents/administration & dosage MH - Antibiotic Prophylaxis/*statistics & numerical data MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Unnecessary Procedures EDAT- 2006/12/26 09:00 MHDA- 2008/03/11 09:00 CRDT- 2006/12/26 09:00 PHST- 2006/11/08 00:00 [accepted] PHST- 2006/12/26 09:00 [pubmed] PHST- 2008/03/11 09:00 [medline] PHST- 2006/12/26 09:00 [entrez] AID - S0266-4356(06)00237-3 [pii] AID - 10.1016/j.bjoms.2006.11.005 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2008 Mar;46(2):133-5. doi: 10.1016/j.bjoms.2006.11.005. Epub 2006 Dec 22. PMID- 25622882 OWN - NLM STAT- MEDLINE DCOM- 20150526 LR - 20201209 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 4 DP - 2015 Apr TI - A double-blind randomized study evaluating the effect of intra-alveolar chlorhexidine gel on alveolar osteitis after removal of mandibular third molars. PG - 600-5 LID - S0278-2391(14)01407-4 [pii] LID - 10.1016/j.joms.2014.08.035 [doi] AB - PURPOSE: The main purpose of the present investigation was to determine whether intra-alveolar chlorhexidine (CHX) gel is an effective preventative treatment for alveolar osteitis (AO), as has been strongly suggested by previous investigators. Another goal was to evaluate whether there is a correlation between the use of analgesics during the postoperative week and the development of AO, a correlation that could be a supplement to the commonly used diagnostic criteria for AO. MATERIALS AND METHODS: A double-blinded randomized study was performed to assess whether intra-alveolar administration of CHX decreases AO. To achieve this objective, the extraction and postoperative course of 100 impacted mandibular third molars were studied. Ninety-seven percent of teeth operated on had a diagnosed pathology. The extraction alveoli were treated with CHX or placebo. The intake of analgesics was recorded for 7 days after the operation. RESULTS: Statistically important differences in AO between the control and experimental groups were not found. The intake of analgesics reflected the occurrence of AO with a high degree of importance. CONCLUSION: The present study did not verify that application of CHX gel improves healing after removal of impacted third molars. The patients' postoperative analgesic intake reflected the development of AO. CI - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Freudenthal, Nelly AU - Freudenthal N AD - Eastman Institute Maxillofacial Surgery, Public Dental Service, Stockholm County Council, Stockholm, Sweden. Electronic address: nelly.freudenthal@ftv.sll.se. FAU - Sternudd, Mika AU - Sternudd M AD - Public Dental Service, Gotland County, Visby, Sweden. FAU - Jansson, Leif AU - Jansson L AD - Head, Department of Periodontology, Public Dental Service at Kista and Skanstull, Stockholm County Council, Stockholm; Adjunct Lecturer, Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. FAU - Wannfors, Karin AU - Wannfors K AD - Former Head, Oral and Maxillofacial Clinic, Sodersjukhuset, Stockholm, Sweden. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20140916 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics) RN - 0 (Anti-Infective Agents, Local) RN - 0 (Drug Combinations) RN - 0 (Gels) RN - 0 (Placebos) RN - 0 (acetaminophen, codeine drug combination) RN - 362O9ITL9D (Acetaminophen) RN - R4KO0DY52L (Chlorhexidine) RN - UX6OWY2V7J (Codeine) SB - AIM SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Aged MH - Analgesics/therapeutic use MH - Anatomic Variation MH - Anti-Infective Agents, Local/*therapeutic use MH - Chlorhexidine/*therapeutic use MH - Codeine/therapeutic use MH - Dental Caries/surgery MH - Double-Blind Method MH - Drug Combinations MH - Dry Socket/*prevention & control MH - Female MH - Gels MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/pathology/*surgery MH - Operative Time MH - Pericoronitis/surgery MH - Periodontal Diseases/surgery MH - Placebos MH - Surgical Flaps/surgery MH - *Tooth Extraction MH - Tooth Socket/*drug effects MH - Tooth, Impacted/pathology/surgery MH - Young Adult EDAT- 2015/01/28 06:00 MHDA- 2015/05/27 06:00 CRDT- 2015/01/28 06:00 PHST- 2014/05/15 00:00 [received] PHST- 2014/08/22 00:00 [revised] PHST- 2014/08/27 00:00 [accepted] PHST- 2015/01/28 06:00 [entrez] PHST- 2015/01/28 06:00 [pubmed] PHST- 2015/05/27 06:00 [medline] AID - S0278-2391(14)01407-4 [pii] AID - 10.1016/j.joms.2014.08.035 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Apr;73(4):600-5. doi: 10.1016/j.joms.2014.08.035. Epub 2014 Sep 16. PMID- 15998557 OWN - NLM STAT- MEDLINE DCOM- 20060411 LR - 20111117 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 44 IP - 1 DP - 2006 Feb TI - Re: Renton T, Hankins M, Sproate C, McGurk M. A randomised controlled clinical trial to compare the incidence of injury to the inferior alveolar nerve as a result of coronectomy and removal of mandibular third molars. Br J Oral Maxillofac Surg 2005;43(4):7-12. PG - 75-6; author reply 76-7 FAU - Meek, Marcel F AU - Meek MF FAU - Coert, J Henk AU - Coert JH FAU - de Visscher, Jan G A M AU - de Visscher JG LA - eng PT - Comment PT - Comparative Study PT - Letter DEP - 20050705 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM CON - Br J Oral Maxillofac Surg. 2005 Feb;43(1):7-12. PMID: 15620767 MH - Cranial Nerve Injuries/*etiology MH - Humans MH - Mandible MH - Molar, Third/*surgery MH - Sensation Disorders/etiology MH - Tooth Crown/*surgery MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - *Trigeminal Nerve Injuries EDAT- 2005/07/07 09:00 MHDA- 2006/04/12 09:00 CRDT- 2005/07/07 09:00 PHST- 2005/01/19 00:00 [received] PHST- 2005/03/21 00:00 [accepted] PHST- 2005/07/07 09:00 [pubmed] PHST- 2006/04/12 09:00 [medline] PHST- 2005/07/07 09:00 [entrez] AID - S0266-4356(05)00127-0 [pii] AID - 10.1016/j.bjoms.2005.03.029 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2006 Feb;44(1):75-6; author reply 76-7. doi: 10.1016/j.bjoms.2005.03.029. Epub 2005 Jul 5. PMID- 3422792 OWN - NLM STAT- MEDLINE DCOM- 19880405 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 35 IP - 1 DP - 1988 Jan-Feb TI - Comparison between lidocaine and bupivacaine as local anesthetics with diflunisal for postoperative pain control after lower third molar surgery. PG - 1-4 AB - The effect of lidocaine and bupivacaine on postoperative pain were compared in a double blind crossover study. Diflunisal (500 mg) was used as an analgesic and given before commencement of the surgical procedure.Bilateral impactions of lower third molars were removed on two occasions, four weeks apart, in a sample of 26 Chinese patients. One local anesthetic was used on one occasion and the alternate on the second. Pain intensity was indicated on a visual analogue scale hourly for eight hours, beginning one hour after the start of surgery.Pain at each postoperative hour was lower after bupivacaine and more patients indicated little or no pain after bupivacaine than after lidocaine. This was not reflected in patients' preference: 12 preferring lidocaine, 11 bupivacaine, and 3 indicating no preference, an important reason being a shorter period of numbness with lidocaine.Although diflunisal was given preoperatively, the postoperative course was not complicated by alveolitis in any case.While bupivacaine plus diflunisal resulted in less postoperative pain than lidocaine plus diflunisal, some patients were willing to sustain some pain after oral surgery if sensation was regained sooner. FAU - Rosenquist, J B AU - Rosenquist JB FAU - Rosenquist, K I AU - Rosenquist KI FAU - Lee, P K AU - Lee PK LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Salicylates) RN - 7C546U4DEN (Diflunisal) RN - 98PI200987 (Lidocaine) RN - Y8335394RO (Bupivacaine) SB - D MH - Adult MH - *Anesthesia, Dental MH - *Anesthesia, Local MH - *Bupivacaine MH - *Diflunisal MH - Double-Blind Method MH - Female MH - Humans MH - *Lidocaine MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*prevention & control MH - *Salicylates MH - Tooth Extraction MH - Tooth, Impacted/surgery PMC - PMC2190058 EDAT- 1988/01/01 00:00 MHDA- 1988/01/01 00:01 CRDT- 1988/01/01 00:00 PHST- 1988/01/01 00:00 [pubmed] PHST- 1988/01/01 00:01 [medline] PHST- 1988/01/01 00:00 [entrez] PST - ppublish SO - Anesth Prog. 1988 Jan-Feb;35(1):1-4. PMID- 10982947 OWN - NLM STAT- MEDLINE DCOM- 20001005 LR - 20151123 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 90 IP - 3 DP - 2000 Sep TI - Alveolar osteitis prevention by immediate placement of medicated packing. PG - 282-4 AB - OBJECTIVE: The purpose of this study was to evaluate whether immediate placement of medicated dry socket packing would decrease the incidence of alveolar osteitis (dry socket) with lower third molar extractions. STUDY DESIGN: In 100 patients, 200 lower third molars were extracted. One half of the sockets were packed to the crest of the alveolar ridge with a one-quarter-inch radiograph-detectable filament gauze that contained 9% eugenol, 36% balsam of Peru, and 55% petroleum jelly. The medicated packing was removed 1 week after surgery. None of the patients were taking antibiotics. Patients were instructed to increase their oral hygiene before and after surgery and were to use 0.12% chlorhexidine gluconate 2 days before and 3 days after surgery. RESULTS; Two hundred bilateral lower third molars of varying difficulty were extracted. The overall alveolar osteitis rate was 34 (17%). The immediately packed lower third molar sites had an alveolar osteitis rate of 8 (8%). The sockets that were not packed with medicated packing the day of surgery had an alveolar osteitis rate of 26 (26%). The difference was statistically significant (P =.001). CONCLUSION: The results of this study suggest that placement of medicated dry socket packing immediately after lower third molar extraction decreases the alveolar osteitis rate. FAU - Bloomer, C R AU - Bloomer CR LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Balsams) RN - 3T8H1794QW (Eugenol) RN - 8009-03-8 (Petrolatum) RN - 8P5F881OCY (Peruvian balsam) SB - D SB - IM MH - Adolescent MH - Adult MH - Balsams/administration & dosage MH - Chi-Square Distribution MH - Dry Socket/etiology/*prevention & control MH - Eugenol/administration & dosage MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - *Occlusive Dressings MH - Petrolatum/administration & dosage MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Treatment Outcome EDAT- 2000/09/13 11:00 MHDA- 2000/10/07 11:01 CRDT- 2000/09/13 11:00 PHST- 2000/09/13 11:00 [pubmed] PHST- 2000/10/07 11:01 [medline] PHST- 2000/09/13 11:00 [entrez] AID - S1079-2104(00)94121-0 [pii] AID - 10.1067/moe.2000.108919 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Sep;90(3):282-4. doi: 10.1067/moe.2000.108919. PMID- 8866072 OWN - NLM STAT- MEDLINE DCOM- 19970114 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 34 IP - 4 DP - 1996 Aug TI - The use of an information leaflet for patients undergoing wisdom tooth removal. PG - 331-4 AB - Attempts to inform the patient about surgical procedures have increased for the purposes of ensuring informed consent and improving satisfaction with the service provided. Leaflets are being used as an additional aid in general practice and in hospital units. However, such written information is seldom evaluated. This study was conducted to assess the influence of using an information leaflet for patients attending oral surgery clinics at a local dental hospital. Sixty-six patients were included in the study and invited to complete a questionnaire to assess knowledge of wisdom tooth removal at the time of examination and just prior to surgery. The validity of the knowledge measure had been previously tested. At 1 month follow-up a patient satisfaction questionnaire was completed by the sample. Patients were randomised at the examination appointment into four groups. The first group was provided with the leaflet and prompted to read it by the dentist (WTL + Prompt). The second group was given the leaflet but not prompted (WTL only). The two other groups acted as controls. The third group was provided with a dental health education leaflet with no prompting (Control 1). The fourth and final group was given no additional written material (Control 2) but provided with verbal information and routine warnings in a similar way to all other groups participating in the study. The WTL + Prompt Group showed increased knowledge on retest (P < 0.001). The WTL Group showed a trend to greater knowledge (P < 0.06) however the control groups showed no improvement (P > 0.5). Patient satisfaction, although greatest in the group given a leaflet without prompting, was not simply related to leaflet provision. FAU - O'Neill, P AU - O'Neill P AD - Department of Clinical Dental Sciences, Liverpool Dental School, UK. FAU - Humphris, G M AU - Humphris GM FAU - Field, E A AU - Field EA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Analysis of Variance MH - Communication MH - Dental Service, Hospital MH - Dentist-Patient Relations MH - England MH - Follow-Up Studies MH - Health Education, Dental MH - Humans MH - Informed Consent MH - Molar, Third/*surgery MH - *Pamphlets MH - Patient Education as Topic/*methods MH - Patient Satisfaction MH - Reproducibility of Results MH - Surgery, Oral MH - Surveys and Questionnaires MH - *Tooth Extraction EDAT- 1996/08/01 00:00 MHDA- 1996/08/01 00:01 CRDT- 1996/08/01 00:00 PHST- 1996/08/01 00:00 [pubmed] PHST- 1996/08/01 00:01 [medline] PHST- 1996/08/01 00:00 [entrez] AID - 10.1016/s0266-4356(96)90014-5 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1996 Aug;34(4):331-4. doi: 10.1016/s0266-4356(96)90014-5. PMID- 1545974 OWN - NLM STAT- MEDLINE DCOM- 19920414 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 73 IP - 3 DP - 1992 Mar TI - Evaluation of intra-alveolar chlorhexidine dressings after removal of impacted mandibular third molars. PG - 383-8 AB - Chlorhexidine gluconate (CHX) has been investigated for its possible benefit in the prevention of alveolar osteitis complicating third molar removal. In a double-blind, placebo-controlled clinical study, 70 randomly selected healthy patients were subjected to uncomplicated mandibular third molar removal followed by CHX-gelatin sponge and saline solution-gelatin sponge intra-alveolar dressings. Each patient was followed for 6 days for postoperative discomfort and complications, and scored accordingly. The results demonstrated that patients receiving 0.2% CHX intra-alveolar dressings exhibited a significant reduction in postoperative discomfort and complications when compared with saline solution-treated control sites (p less than 0.005). Further, this phenomenon was not found to be related to patient factors including age, sex, and race, nor did any correlation exist between treated or control sites, and surgical factors including performing surgeon, surgeon's dominant hand, time of surgery, surgical site, and difficulty of the removal. These findings warrant further studies concerning the apparent clinical benefit of postextraction intra-alveolar CHX dressings for the reduction of postoperative alveolar osteitis. FAU - Fotos, P G AU - Fotos PG AD - Department of Oral Pathology, Radiology, and Medicine, University of Iowa College of Dentistry, Iowa City. FAU - Koorbusch, G F AU - Koorbusch GF FAU - Sarasin, D S AU - Sarasin DS FAU - Kist, R J AU - Kist RJ LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - MOR84MUD8E (chlorhexidine gluconate) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adult MH - Chlorhexidine/*analogs & derivatives/therapeutic use MH - Double-Blind Method MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Periodontal Dressings MH - Surgical Wound Infection/*prevention & control MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1992/03/01 00:00 MHDA- 1992/03/01 00:01 CRDT- 1992/03/01 00:00 PHST- 1992/03/01 00:00 [pubmed] PHST- 1992/03/01 00:01 [medline] PHST- 1992/03/01 00:00 [entrez] AID - 10.1016/0030-4220(92)90140-l [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1992 Mar;73(3):383-8. doi: 10.1016/0030-4220(92)90140-l. PMID- 16939026 OWN - NLM STAT- MEDLINE DCOM- 20061018 LR - 20131121 IS - 0894-8275 (Print) IS - 0894-8275 (Linking) VI - 19 IP - 4 DP - 2006 Aug TI - Effect of Er:YAG laser irradiation distance on superficial dentin morphology. PG - 217-21 AB - PURPOSE: To assess in vitro the effect of Er:YAG laser irradiation distance on dentin surface morphology, by SEM. METHODS: 60 sound human third molars were employed to obtain discs (approximately equal to 1mm thick), that were polished to standardize the smear layer. Discs were randomly assigned to six groups (n=10) and sequentially bisected. Five groups (including both disc halves of each sample) received Er:YAG laser irradiation (80mJ/2Hz) for 20s, according to the irradiation distance (11, 12, 14, 16 or 17mm) and one was the control group. In the lased-groups, one disc half was separated for superficial analysis without subsequent acid-etching and the other half received phosphoric acid for 15 seconds. In the control group, one disc half was treated with phosphoric acid and no superficial treatment was done in the other half. Specimens were prepared for SEM. RESULTS: Er:YAG laser-irradiated specimens, regardless of the irradiation distance, showed an irregular and scaly surface, with intense ablation of the intertubular dentin, mainly when the irradiation was performed in the focused mode (12 mm). The smear layer was removed and dentin tubules were opened, however, no tubule enlargement was found, unlike the group that only received acid application. The irradiation with 17 mm resulted in a surface appearance more homogeneous than those presented with other distances closer to the focus. The subsequent acid-etching on the lased surfaces decreased the superficial irregularities with partial exposure and enlargement of dentin tubules, in all the tested irradiation distances. FAU - de Souza-Gabriel, Aline Evangelista AU - de Souza-Gabriel AE AD - Department of Restorative Dentistry, University of São Paulo (USP), Ribeirão Preto School of Dentistry, Av. do Café, S/N, Monte Alegre, CEP: 14040-904 Ribeirão Preto, SP, Brazil. aline.evangelista@gmail.com FAU - Chinelatti, Michelle Alexandra AU - Chinelatti MA FAU - Borsatto, Maria Cristina AU - Borsatto MC FAU - Pecora, Jesus Djalma AU - Pecora JD FAU - Palma-Dibb, Regina Guenka AU - Palma-Dibb RG FAU - Corona, Silmara Aparecida Milori AU - Corona SA LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Dent JT - American journal of dentistry JID - 8806701 RN - 0 (yttrium-aluminum-garnet) RN - 58784XQC3Y (Yttrium) RN - 77B218D3YE (Erbium) RN - CPD4NFA903 (Aluminum) SB - D MH - Acid Etching, Dental/adverse effects MH - Aluminum/therapeutic use MH - Dentin/*radiation effects/ultrastructure MH - Erbium/therapeutic use MH - Humans MH - *Laser Therapy MH - Molar, Third/*radiation effects MH - Surface Properties/radiation effects MH - Yttrium/therapeutic use EDAT- 2006/08/31 09:00 MHDA- 2006/10/19 09:00 CRDT- 2006/08/31 09:00 PHST- 2006/08/31 09:00 [pubmed] PHST- 2006/10/19 09:00 [medline] PHST- 2006/08/31 09:00 [entrez] PST - ppublish SO - Am J Dent. 2006 Aug;19(4):217-21. PMID- 21217614 OWN - NLM STAT- MEDLINE DCOM- 20120105 LR - 20190608 IS - 1698-6946 (Electronic) IS - 1698-4447 (Linking) VI - 16 IP - 6 DP - 2011 Sep 1 TI - Preemptive analgesic effectiveness of oral ketorolac plus local tramadol after impacted mandibular third molar surgery. PG - e776-80 AB - OBJECTIVE: The aim of this study was to compare preemptive analgesia of oral ketorolac plus submucous local placebo with oral ketorolac plus submucous local tramadol after impacted mandibular third molar surgery. STUDY DESIGN: A double-blind, randomized, placebo-controlled clinical trial was conducted. Patients were randomized into two treatment groups (n = 15 per group): group A, oral ketorolac 10 mg, 30 minutes before surgery plus submucous local placebo (1 mL saline solution); group B, oral ketorolac 10 mg, 30 minutes before surgery plus submucous local tramadol (50 mg diluted in 1 mL saline solution). We evaluated the intensity of pain, time for the first analgesic rescue medication, and total analgesic consumption. RESULTS: Pain intensity, number of patients requiring analgesic rescue medication, number of patients in each group not requiring analgesic rescue medication, and total analgesic consumption showed statistical significance. CONCLUSIONS: Preemptive use of oral ketorolac plus submucous local tramadol is an alternative treatment for acute pain after surgical removal of an impacted mandibular third molar. FAU - Isiordia-Espinoza, Mario A AU - Isiordia-Espinoza MA AD - Escuela Superior de Medicina, Instituto Politécnico Nacional, D.F., México. FAU - Pozos-Guillén, Amaury J AU - Pozos-Guillén AJ FAU - Martínez-Rider, Ricardo AU - Martínez-Rider R FAU - Herrera-Abarca, Jorge E AU - Herrera-Abarca JE FAU - Pérez-Urizar, José AU - Pérez-Urizar J LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20110901 PL - Spain TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 39J1LGJ30J (Tramadol) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Administration, Oral MH - Administration, Topical MH - Analgesics, Opioid/*administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Ketorolac/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Tooth, Impacted/*surgery MH - Tramadol/*administration & dosage MH - Young Adult EDAT- 2011/01/11 06:00 MHDA- 2012/01/06 06:00 CRDT- 2011/01/11 06:00 PHST- 2010/02/22 00:00 [received] PHST- 2010/05/22 00:00 [accepted] PHST- 2011/01/11 06:00 [entrez] PHST- 2011/01/11 06:00 [pubmed] PHST- 2012/01/06 06:00 [medline] AID - 16854 [pii] AID - 10.4317/medoral.16854 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2011 Sep 1;16(6):e776-80. doi: 10.4317/medoral.16854. PMID- 24262040 OWN - NLM STAT- MEDLINE DCOM- 20140512 LR - 20131122 IS - 1002-0098 (Print) IS - 1002-0098 (Linking) VI - 48 IP - 7 DP - 2013 Jul TI - [Clinical observation of influence of warfarin on post-operative bleeding after tooth extraction in the elderly]. PG - 385-7 AB - OBJECTIVE: To investigate the feasibility of continuing warfarin when international normalized ratio (INR) was less than 2.5 before tooth extraction in the elderly. METHODS: One hundred elderly outpatients with prolong use of warfarin and maintaining INR < 2.5 before tooth extraction served as observation group, 200 elderly outpatients without taking anticoagulant and antiplatelet medicine served as control group. All the patients underwent a single non-impacted tooth extraction. Postoperative bleeding at different time was observed. RESULTS: There was significant difference in postoperative bleeding at 5, 10, 30 min, 24 h after extraction and there was no significant difference at 48 h between control group and observation group (P < 0.05) and no bleeding was found in either group at 48 h (incidence of bleeding were 0%). CONCLUSIONS: It was feasible to continue warfarin for the elderly maintaining INR < 2.5 undergoing a single non-impacted tooth extraction by monitoring postoperative bleeding and hemostatic treatment measures. FAU - Wang, Wen-ying AU - Wang WY AD - Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China. FAU - Cui, Nian-hui AU - Cui NH FAU - Wang, En-bo AU - Wang EB FAU - Zhang, Wei AU - Zhang W LA - chi PT - Controlled Clinical Trial PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China TA - Zhonghua Kou Qiang Yi Xue Za Zhi JT - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology JID - 8711066 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Anticoagulants/administration & dosage/*adverse effects MH - Female MH - Humans MH - International Normalized Ratio MH - Male MH - Middle Aged MH - Postoperative Hemorrhage/*etiology MH - Tooth Extraction/*adverse effects MH - Warfarin/administration & dosage/*adverse effects EDAT- 2013/11/23 06:00 MHDA- 2014/05/13 06:00 CRDT- 2013/11/23 06:00 PHST- 2013/11/23 06:00 [entrez] PHST- 2013/11/23 06:00 [pubmed] PHST- 2014/05/13 06:00 [medline] PST - ppublish SO - Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jul;48(7):385-7. PMID- 1714761 OWN - NLM STAT- MEDLINE DCOM- 19910926 LR - 20190912 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 29 IP - 3 DP - 1991 Jun TI - A double blind clinical trial to assess the value of aprotinin in third molar surgery. PG - 176-9 AB - The bovine derived polypeptide, aprotinin, inhibits the activation of certain chemical mediators of acute inflammation. These mediators are responsible for causing pain and swelling in traumatised tissue. The properties of aprotinin were assessed in patients requiring surgical removal of third molars, a procedure which often results in considerable postoperative pain and swelling. A double blind clinical trial compared the effects of local infiltration of 1 ml of saline on one side of the mouth and aprotinin (10,000 international units) on the other, in patients requiring extraction of both mandibular third molars. Pain scores were assessed with a visual analogue scale, and swelling was subjectively assessed. The results, when analysed statistically, showed that aprotinin significantly reduced postoperative pain and swelling on the side of the mouth on which it was used, as compared to the control side (0.01% significance). FAU - Brennan, P A AU - Brennan PA AD - Department of Oral and Maxillofacial Surgery, Mount Vernon Hospital, Northwood, Middlesex. FAU - Gardiner, G T AU - Gardiner GT FAU - McHugh, J AU - McHugh J LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 9087-70-1 (Aprotinin) SB - D SB - IM MH - Administration, Oral MH - Administration, Topical MH - Adolescent MH - Adult MH - Aprotinin/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Edema/prevention & control MH - Humans MH - Mandibular Diseases/prevention & control MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1991/06/01 00:00 MHDA- 1991/06/01 00:01 CRDT- 1991/06/01 00:00 PHST- 1991/06/01 00:00 [pubmed] PHST- 1991/06/01 00:01 [medline] PHST- 1991/06/01 00:00 [entrez] AID - 10.1016/0266-4356(91)90033-2 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1991 Jun;29(3):176-9. doi: 10.1016/0266-4356(91)90033-2. PMID- 9879213 OWN - NLM STAT- MEDLINE DCOM- 19990114 LR - 20161124 IS - 0250-832X (Print) IS - 0250-832X (Linking) VI - 27 IP - 5 DP - 1998 Sep TI - Evaluation of a new radiographic technique: diagnostic accuracy for mandibular third molars. PG - 255-63 AB - OBJECTIVE: To compare the accuracy of Scanora with that of traditional panoramic and intra-oral radiography for the assessment of impacted mandibular third molars. METHODS: Two hundred and fifty-four patients referred for removal of impacted or partly erupted third molars were randomly allocated to one of two groups; 133 were examined by the Scanora system and 121 by a panoramic plus a series of three intra-oral radiographs. The radiographs were read by a trained oral radiologist and her diagnoses validated against the surgeons' findings at operation. RESULTS: There was agreement about the state of tooth eruption in 71.4% of Scanora and 74.4% of conventional examinations and about tooth position in 77.2 and 69.7% respectively (P < 0.05). The number of roots was assessed more accurately by Scanora (82.7% agreement) than by conventional (71% agreement) examination (P < 0.05). There was agreement about the root morphology in 70.4% of Scanora and 62.4% of conventional examinations. In 12% of the patients, the roots were in very close contact with the canal determined by the surgeon. In approximately 50% of these cases, the close contact to the canal was found by radiography with no significant differences between the methods. CONCLUSION: The Scanora method was more accurate when validated against the surgeons' findings for the position and number of roots of ectopic mandibular third molars while both methods were equally accurate in demonstrating the relation between the roots and the inferior alveolar nerve. FAU - Wenzel, A AU - Wenzel A AD - Department of Oral Radiology, Royal Dental College, University of Aarhus, Denmark. FAU - Aagaard, E AU - Aagaard E FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - D MH - Adolescent MH - Adult MH - Evaluation Studies as Topic MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*diagnostic imaging/surgery MH - *Radiography, Dental, Digital MH - Radiography, Panoramic MH - Reproducibility of Results MH - Statistics, Nonparametric MH - Tooth, Impacted/*diagnostic imaging/surgery MH - Tooth, Unerupted/diagnostic imaging/surgery EDAT- 1999/01/08 00:00 MHDA- 1999/01/08 00:01 CRDT- 1999/01/08 00:00 PHST- 1999/01/08 00:00 [pubmed] PHST- 1999/01/08 00:01 [medline] PHST- 1999/01/08 00:00 [entrez] AID - 10.1038/sj/dmfr/4600359 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 1998 Sep;27(5):255-63. doi: 10.1038/sj/dmfr/4600359. PMID- 4578853 OWN - NLM STAT- MEDLINE DCOM- 19731005 LR - 20191030 IS - 0007-117X (Print) IS - 0007-117X (Linking) VI - 10 IP - 3 DP - 1973 Mar TI - The effect of Nivemycin on pain and swelling following lower third molar removal. PG - 321-5 FAU - MacGregor, A J AU - MacGregor AJ FAU - Hutchinson, D AU - Hutchinson D LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Surg JT - The British journal of oral surgery JID - 0400651 RN - 0 (Placebos) RN - I16QD7X297 (Neomycin) SB - D SB - IM MH - Clinical Trials as Topic MH - Dry Socket/*drug therapy MH - Humans MH - Molar MH - Neomycin/administration & dosage/*therapeutic use MH - Pain/*drug therapy MH - Placebos MH - *Tooth Extraction EDAT- 1973/03/01 00:00 MHDA- 1973/03/01 00:01 CRDT- 1973/03/01 00:00 PHST- 1973/03/01 00:00 [pubmed] PHST- 1973/03/01 00:01 [medline] PHST- 1973/03/01 00:00 [entrez] AID - 10.1016/s0007-117x(72)80062-3 [doi] PST - ppublish SO - Br J Oral Surg. 1973 Mar;10(3):321-5. doi: 10.1016/s0007-117x(72)80062-3. PMID- 26048100 OWN - NLM STAT- MEDLINE DCOM- 20160803 LR - 20181202 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 53 IP - 8 DP - 2015 Oct TI - Re: Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial. Br J Oral Maxillofac Surg 2015 May;53(5):416-20. PG - 779 LID - S0266-4356(15)00168-0 [pii] LID - 10.1016/j.bjoms.2015.05.005 [doi] FAU - Isik, Kubilay AU - Isik K AD - Assoc. Prof., Necmettin Erbakan University, Faculty of Dentistry, Oral and Maxillofacial Surgery Department. Electronic address: kubilay@kubilay.org. FAU - Esen, Alparslan AU - Esen A AD - Assist. Prof., Necmettin Erbakan University, Faculty of Dentistry, Oral and Maxillofacial Surgery Department. LA - eng PT - Comment PT - Letter DEP - 20150603 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM CON - Br J Oral Maxillofac Surg. 2015 May;53(5):416-20. PMID: 25794779 MH - *Antibiotic Prophylaxis MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Surgical Wound Infection/*prevention & control MH - Tooth, Impacted/*surgery EDAT- 2015/06/07 06:00 MHDA- 2016/08/04 06:00 CRDT- 2015/06/07 06:00 PHST- 2015/04/30 00:00 [received] PHST- 2015/05/07 00:00 [accepted] PHST- 2015/06/07 06:00 [entrez] PHST- 2015/06/07 06:00 [pubmed] PHST- 2016/08/04 06:00 [medline] AID - S0266-4356(15)00168-0 [pii] AID - 10.1016/j.bjoms.2015.05.005 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2015 Oct;53(8):779. doi: 10.1016/j.bjoms.2015.05.005. Epub 2015 Jun 3. PMID- 8229393 OWN - NLM STAT- MEDLINE DCOM- 19931202 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 51 IP - 11 DP - 1993 Nov TI - Prevention of postsurgical bleeding in oral surgery using tranexamic acid without dose modification of oral anticoagulants. PG - 1211-6 AB - The hemostatic effect of tranexamic acid solution (4.8%) used as a mouthwash was compared with a placebo solution in 93 patients on continuous, unchanged, oral anticoagulant treatment undergoing oral surgery. The investigation was a randomized, double-blind, placebo-controlled, multicenter study. Before suturing, the surgically treated region was irrigated with 10 mL of tranexamic acid (46 patients) or placebo (47 patients) solution. The patients then performed mouthwash with 10 mL of the solution for 2 minutes four times daily for 7 days. The treatment groups were comparable regarding age, smoking habits, and surgery. Laboratory variables measuring vitamin K-dependent coagulation factors were within therapeutic ranges (international normalized ratio 4.00 to 2.10). One of the clinics used a different method for these measurements and therefore the levels of coagulation factor X in plasma obtained for the three clinics were compared. No significant difference in the range at which surgery was performed was found between clinics. In the placebo group, 10 patients developed bleeding requiring treatment, while none of the patients treated with tranexamic acid solution had bleeding. This difference was statistically significant (P < .01). The treatment with mouthwash was well tolerated. It was concluded that patients on oral anticoagulants can undergo oral surgery within the therapeutic range without reducing the dosage of anticoagulants, provided that local antifibrinolytic treatment with tranexamic acid solution is instituted. FAU - Ramström, G AU - Ramström G AD - Department of Oral and Jaw Diseases, Karolinska Hospital, Stockholm, Sweden. FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S FAU - Hall, G AU - Hall G FAU - Blombäck, M AU - Blombäck M FAU - Alander, U AU - Alander U LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anticoagulants) RN - 0 (Mouthwashes) RN - 6T84R30KC1 (Tranexamic Acid) SB - AIM SB - D SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Analysis of Variance MH - *Anticoagulants/administration & dosage/adverse effects MH - Cardiovascular Diseases/drug therapy MH - *Dental Care for Chronically Ill MH - Dental Pulp Diseases/surgery MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - Mouthwashes/therapeutic use MH - Oral Hemorrhage/etiology/*prevention & control MH - Postoperative Complications/*prevention & control MH - Surgery, Oral/*methods MH - Tooth Extraction MH - Tranexamic Acid/*therapeutic use EDAT- 1993/11/01 00:00 MHDA- 1993/11/01 00:01 CRDT- 1993/11/01 00:00 PHST- 1993/11/01 00:00 [pubmed] PHST- 1993/11/01 00:01 [medline] PHST- 1993/11/01 00:00 [entrez] AID - S0278239193000230 [pii] AID - 10.1016/s0278-2391(10)80291-5 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1993 Nov;51(11):1211-6. doi: 10.1016/s0278-2391(10)80291-5. PMID- 15660084 OWN - NLM STAT- MEDLINE DCOM- 20050225 LR - 20131121 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 99 IP - 2 DP - 2005 Feb TI - Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. PG - 155-9 AB - OBJECTIVE: The objective of this study was to assess if chlorhexidine (CHX) rinse decreases the occurrence of alveolar osteitis (AO) following third molar removal. STUDY DESIGN: A literature search identified 7 randomized prospective clinical trials reporting incidence of AO following removal of mandibular third molars. Studies were combined into 2 groups and summary relative risks were calculated for each group. One group of studies evaluated rinsing on the day of surgery only and the second group of studies rinsed at least on the day of surgery and several days after surgery. RESULTS: The relative risk for the single rinse group was 1.36 (95% confidence interval [CI] 0.80, 2.33), P>.05, whereas for the multiple rinse group, the relative risk was 1.90 (95% CI 1.46, 2.47), P<.05. CONCLUSION: Rinsing with CHX on the day of surgery and several days after may reduce the incidence of AO. FAU - Caso, Antonio AU - Caso A AD - University of Washington School of Dentistry, Department of Oral and Maxillofacial Surgery, Seattle, WA 98195-7134, USA. FAU - Hung, Li-Kuei AU - Hung LK FAU - Beirne, O Ross AU - Beirne OR LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Mouthwashes) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM CIN - Evid Based Dent. 2005;6(2):36. PMID: 16208386 MH - Anti-Infective Agents, Local/administration & dosage/*therapeutic use MH - Chlorhexidine/administration & dosage/*therapeutic use MH - Confidence Intervals MH - Dry Socket/*prevention & control MH - Humans MH - Mandible/surgery MH - Molar, Third/surgery MH - Mouthwashes/administration & dosage/*therapeutic use MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Tooth Extraction EDAT- 2005/01/22 09:00 MHDA- 2005/02/26 09:00 CRDT- 2005/01/22 09:00 PHST- 2005/01/22 09:00 [pubmed] PHST- 2005/02/26 09:00 [medline] PHST- 2005/01/22 09:00 [entrez] AID - S1079210404003452 [pii] AID - 10.1016/j.tripleo.2004.05.009 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):155-9. doi: 10.1016/j.tripleo.2004.05.009. PMID- 16685298 OWN - NLM STAT- MEDLINE DCOM- 20060612 LR - 20131121 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 7 IP - 2 DP - 2006 May 1 TI - Comparison of two chlorhexidine rinse protocols on the incidence of alveolar osteitis following the surgical removal of impacted third molars. PG - 79-86 AB - PRINCIPLES: Alveolar osteitis (dry socket) is the most common complication following the extraction of permanent teeth. This study was undertaken to compare the effect of two chlorhexidine rinse protocols on the incidence of alveolar osteitis in patients undergoing surgical removal of impacted mandibular third molar teeth. METHODS: A prospective randomized clinical trial was conducted among 99 subjects. Patients were randomly assigned into two groups. Subjects were instructed to rinse twice daily with 15 ml of chlorhexidine rinse 30 seconds for one week before and one week after surgery (group I) or one week after surgery (group II). Postoperatively, all patients were instructed to return in one week or sooner if bothersome pain increased or persisted. Data were collected regarding abnormal healing, presence of necrotic tissue, exposed bone, and absence of clot. RESULTS: The results indicated group I and group II were not statistically significant different in the reduction of alveolar osteitis. CONCLUSIONS: To reduce alveolar osteitis after impacted third molar surgery, it was observed use of postoperative chlorhexidine rinse was adequate. The postoperative use of chlorhexidine is more feasible than both preoperative and postoperative use. FAU - Metin, Murat AU - Metin M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey. mmuratm@yahoo.com FAU - Tek, Mustafa AU - Tek M FAU - Sener, Ismail AU - Sener I LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20060501 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Mouthwashes) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Infective Agents, Local/*administration & dosage MH - Chlorhexidine/*administration & dosage MH - Double-Blind Method MH - Dry Socket/etiology/*prevention & control MH - Feasibility Studies MH - Humans MH - Molar, Third/*surgery MH - Mouthwashes/*administration & dosage MH - Postoperative Care MH - Preoperative Care MH - Prospective Studies MH - Smoking MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 2006/05/11 09:00 MHDA- 2006/06/13 09:00 CRDT- 2006/05/11 09:00 PHST- 2006/05/11 09:00 [pubmed] PHST- 2006/06/13 09:00 [medline] PHST- 2006/05/11 09:00 [entrez] AID - 1526-3711-306 [pii] PST - epublish SO - J Contemp Dent Pract. 2006 May 1;7(2):79-86. PMID- 16876040 OWN - NLM STAT- MEDLINE DCOM- 20060816 LR - 20131121 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 102 IP - 2 DP - 2006 Aug TI - The effect of sodium hypochlorite application on the success of calcium hydroxide pulpotomy in primary teeth. PG - e22-6 AB - OBJECTIVE: The aim of this study was to evaluate the effects of 3% sodium hypochlorite (NaOCl) used as a hemostatic agent on the outcome of calcium hydroxide pulpotomies of primary teeth. STUDY DESIGN: A total of 18 primary molars with advanced caries and root resorption of approximately half the root length were randomly placed into 2 groups. Conventional calcium hydroxide pulpotomies were performed on teeth in both groups; however, a cotton pellet saturated with 3% sodium hypochlorite was applied to teeth in the treatment group for 30 seconds before the pulpotomy to control hemorrhage. After the extraction of the teeth, they were examined histologically. RESULTS: In the histologic evaluation it was found that none of the specimens in the control group showed necrosis and 1 specimen in the treatment group showed partial necrosis. CONCLUSION: It was found that the use of 3% NaOCl as a hemostatic agent had no effect on the outcome of calcium hydroxide pulpotomies with the given concentration and timing of the NaOCl treatment and the given observation period. FAU - Tunç, Emine Sen AU - Tunç ES AD - Department of Pediatric Dentistry, Faculty of Dentistry, University of Ondokuz Mayis, Samsun, Kirikkale, Turkey. FAU - Saroğlu, Işil AU - Saroğlu I FAU - Sari, Saziye AU - Sari S FAU - Günhan, Omer AU - Günhan O LA - eng PT - Controlled Clinical Trial PT - Journal Article DEP - 20060608 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Hemostatics) RN - DY38VHM5OD (Sodium Hypochlorite) RN - PF5DZW74VN (Calcium Hydroxide) SB - D SB - IM MH - Adolescent MH - Calcium Hydroxide MH - Child MH - Hemostatics/*therapeutic use MH - Humans MH - Molar MH - Pulpotomy/*methods MH - Sodium Hypochlorite/*therapeutic use MH - Tooth, Deciduous EDAT- 2006/08/01 09:00 MHDA- 2006/08/17 09:00 CRDT- 2006/08/01 09:00 PHST- 2005/12/06 00:00 [received] PHST- 2005/12/13 00:00 [revised] PHST- 2005/12/13 00:00 [accepted] PHST- 2006/08/01 09:00 [pubmed] PHST- 2006/08/17 09:00 [medline] PHST- 2006/08/01 09:00 [entrez] AID - S1079-2104(05)01125-X [pii] AID - 10.1016/j.tripleo.2005.12.013 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Aug;102(2):e22-6. doi: 10.1016/j.tripleo.2005.12.013. Epub 2006 Jun 8. PMID- 3091717 OWN - NLM STAT- MEDLINE DCOM- 19861003 LR - 20190919 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 15 IP - 4 DP - 1986 Aug TI - A double-blind, randomized study of naproxen and acetylsalicylic acid after surgical removal of impacted lower third molars. PG - 389-94 AB - 100 patients had an impacted lower 3rd molar surgically removed in a double-blind study. Naproxen (500 mg b.i.d.) or acetylsalicylic acid (ASA) (1 g t.i.d.) were administered to the patients. Paracetamol was allowed as escape medication. 49 patients received naproxen and 51 ASA. 4 patients from each group were excluded because they took other analgesics, took too few tablets, were lost to follow-up or had misunderstood the instructions. There was a significantly better over all analgesic effect of naproxen than ASA (p = 0.004). More patients in the naproxen group than in the ASA group (p less than 0.01) would accept treatment with the same drug again. 4 patients, all from the ASA group, complained spontaneously about side effects. FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S FAU - Petersen, J K AU - Petersen JK FAU - Gøtzsche, P C AU - Gøtzsche PC FAU - Christensen, H AU - Christensen H LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 57Y76R9ATQ (Naproxen) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aspirin/*therapeutic use MH - Clinical Trials as Topic MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Naproxen/*therapeutic use MH - Pain, Postoperative/drug therapy MH - Random Allocation MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 1986/08/01 00:00 MHDA- 1986/08/01 00:01 CRDT- 1986/08/01 00:00 PHST- 1986/08/01 00:00 [pubmed] PHST- 1986/08/01 00:01 [medline] PHST- 1986/08/01 00:00 [entrez] AID - 10.1016/s0300-9785(86)80026-6 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1986 Aug;15(4):389-94. doi: 10.1016/s0300-9785(86)80026-6. PMID- 15741037 OWN - NLM STAT- MEDLINE DCOM- 20050510 LR - 20081121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 34 IP - 3 DP - 2005 May TI - A randomized observer blind comparison of bilateral facial ice pack therapy with no ice therapy following third molar surgery. PG - 281-6 AB - This study compares the efficacy of Tecnol bilateral facial ice packs with no cold therapy in reducing pain, swelling and trismus during the first 24 h following third molar surgery. Sixty patients requiring general anaesthesia for removal of bilateral, impacted third molar teeth were included and randomly assigned to one of two treatment groups. One group received Tecnol bilateral facial ice packs following surgery, while a control group received no form of cold therapy. Facial ice packs were applied in the recovery room within 15 min of the end surgery and patients were asked to use the ice packs continuously for the next 24 h. Surgical and anaesthetic techniques as well as pharmacological regimens were standardized. Postoperative pain levels were compared hourly, for 4 h, then on the evening of surgery and the following morning. Facial swelling and trismus were compared preoperatively and 24 h postoperatively. No statistically significant difference was found between the two treatment groups with respect to pain, facial swelling or trismus. FAU - van der Westhuijzen, A J AU - van der Westhuijzen AJ AD - Department of Maxillo-facial and Oral Surgery, Faculty of Dentistry, University of Stellenbosch, South Africa. AJVDW@sun.ac.za FAU - Becker, P J AU - Becker PJ FAU - Morkel, J AU - Morkel J FAU - Roelse, J A AU - Roelse JA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics) RN - 0 (Ice) SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesics MH - Cryotherapy/*methods MH - Edema/prevention & control MH - Humans MH - Ice MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology/*therapy MH - Single-Blind Method MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Treatment Failure MH - Treatment Outcome MH - Trismus/prevention & control EDAT- 2005/03/03 09:00 MHDA- 2005/05/11 09:00 CRDT- 2005/03/03 09:00 PHST- 2004/05/04 00:00 [accepted] PHST- 2005/03/03 09:00 [pubmed] PHST- 2005/05/11 09:00 [medline] PHST- 2005/03/03 09:00 [entrez] AID - S0901502704001560 [pii] AID - 10.1016/j.ijom.2004.05.006 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2005 May;34(3):281-6. doi: 10.1016/j.ijom.2004.05.006. PMID- 6118380 OWN - NLM STAT- MEDLINE DCOM- 19820212 LR - 20201209 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 21 IP - 10 DP - 1981 Oct TI - The visual analog scale in multiple-dose evaluations of analgesics. PG - 424-9 AB - A double-blind, randomized trial was carried out in patients suffering from pain after removal of an impacted lower wisdom tooth. The analgesic effects of a codeine preparation (Staralgin), a dextropropoxyphene preparation (Doleron novum), and paracetamol were compared in a multiple-dose study of 94 patients. The assessments of pain were made hourly on a visual analog scale, and the evaluation was carried out according to a method which takes into account both duration of effect and number of tablets taken. The most pronounced pain reduction and the highest proportion of pain-free patients were reached with the dextropropoxyphene preparation. The reported side effects were few and equally distributed among the treatment groups. The method of evaluation is discussed, and it was noted that the pain score at tablet intake might be of significant importance in comparison of analgesics. FAU - Quiding, H AU - Quiding H FAU - Oksala, E AU - Oksala E FAU - Happonen, R P AU - Happonen RP FAU - Lehtimäki, K AU - Lehtimäki K FAU - Ojala, T AU - Ojala T LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Analgesics) RN - 0 (Analgesics, Opioid) RN - 362O9ITL9D (Acetaminophen) RN - S2F83W92TK (Dextropropoxyphene) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Analgesics/*administration & dosage/therapeutic use MH - Analgesics, Opioid/therapeutic use MH - Clinical Trials as Topic MH - Codeine/therapeutic use MH - Dextropropoxyphene/therapeutic use MH - Double-Blind Method MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Random Allocation MH - Tooth, Impacted/surgery EDAT- 1981/10/01 00:00 MHDA- 1981/10/01 00:01 CRDT- 1981/10/01 00:00 PHST- 1981/10/01 00:00 [pubmed] PHST- 1981/10/01 00:01 [medline] PHST- 1981/10/01 00:00 [entrez] AID - 10.1002/j.1552-4604.1981.tb01744.x [doi] PST - ppublish SO - J Clin Pharmacol. 1981 Oct;21(10):424-9. doi: 10.1002/j.1552-4604.1981.tb01744.x. PMID- 9643595 OWN - NLM STAT- MEDLINE DCOM- 19980807 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 36 IP - 2 DP - 1998 Apr TI - Dental extractions in patients on warfarin: is alteration of anticoagulant regime necessary? PG - 107-11 AB - Various clinical protocols for the management of warfarinised patients needing dental extractions have been suggested. This study was designed to compare two approaches in the management of these patients. A control group of 32 patients had their warfarin treatment stopped for 2-3 days prior to having dental extractions, resulting in a reduction in the average preoperative international normalised ratio (INR) from 2.6 to 1.6. The study group of 33 patients did not have their anticoagulant treatment altered before extractions, and had an average preoperative INR of 2.7. All patients were treated under local analgesia on an outpatient basis, and local measures-consisting of Surgicel pack and sutures-were used in all cases to control postoperative bleeding from extraction sockets. None of the patients had any immediate postoperative bleeding, and only 1 patient from each group had mild delayed haemorrhage, which was easily controlled with local measures. It is proposed that, provided the INR is within the therapeutic range of 2.0 to 4.0 and local measures are used to control postoperative bleeding, there is no justification in altering warfarin treatment prior to dental extractions in these patients, and thereby exposing them to the risk of thromboembolism. FAU - Devani, P AU - Devani P AD - Department of Oral and Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, UK. FAU - Lavery, K M AU - Lavery KM FAU - Howell, C J AU - Howell CJ LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM CIN - Br J Oral Maxillofac Surg. 1998 Dec;36(6):480. PMID: 9881796 CIN - Br J Oral Maxillofac Surg. 1999 Apr;37(2):150. PMID: 10371325 MH - Adult MH - Aged MH - Aged, 80 and over MH - Ambulatory Surgical Procedures/methods MH - Case-Control Studies MH - Clinical Protocols MH - *Dental Care for Chronically Ill MH - Humans MH - International Normalized Ratio MH - Middle Aged MH - Postoperative Hemorrhage/etiology/prevention & control MH - *Tooth Extraction/adverse effects MH - Warfarin/*administration & dosage EDAT- 1998/06/27 00:00 MHDA- 1998/06/27 00:01 CRDT- 1998/06/27 00:00 PHST- 1998/06/27 00:00 [pubmed] PHST- 1998/06/27 00:01 [medline] PHST- 1998/06/27 00:00 [entrez] AID - 10.1016/s0266-4356(98)90177-2 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1998 Apr;36(2):107-11. doi: 10.1016/s0266-4356(98)90177-2. PMID- 16289676 OWN - NLM STAT- MEDLINE DCOM- 20060518 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 35 IP - 4 DP - 2006 Apr TI - Randomized, double-blind study on effectiveness of intra-alveolar chlorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. PG - 348-51 AB - Chlorhexidine (CHX) mouthwash is a good prophylactic agent for postextraction alveolar osteitis (AO), a very common complication. Recently, a bio-adhesive gel to deliver the active substance, CHX, has been introduced. The intra-alveolar positioning of the bio-adhesive gel allows more direct and prolonged action of CHX, which could be useful in the prevention of AO following extraction of impacted third molars. Presented here is a double-blind, randomised and parallel-group study evaluating the efficacy of the bio-adhesive 0.2% CHX gel (n=53) applied once within the alveolus during third molar surgery, compared to placebo gel only (n=50), in reducing the incidence of impacted third-molar postextraction AO. A 63.33% reduction in the occurrence of AO (P=0.019) was observed in the experimental group. In the control group, the occurrence of AO was 30% compared to 11% in the experimental group. Bio-adhesive 0.2% CHX gel, applied only once within the alveolus site at the time of surgery, may reduce the incidence of AO following removal of impacted third molars. FAU - Torres-Lagares, D AU - Torres-Lagares D AD - Department of Oral Surgery, Faculty of Dentistry, University of Seville, Seville, Spain. danieltl@us.es FAU - Gutierrez-Perez, J L AU - Gutierrez-Perez JL FAU - Infante-Cossio, P AU - Infante-Cossio P FAU - Garcia-Calderon, M AU - Garcia-Calderon M FAU - Romero-Ruiz, M M AU - Romero-Ruiz MM FAU - Serrera-Figallo, M A AU - Serrera-Figallo MA LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20051109 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Gels) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Infective Agents, Local/*administration & dosage MH - Chlorhexidine/*administration & dosage MH - Epidemiologic Methods MH - Female MH - Gels MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Osteitis/*prevention & control MH - Tooth Extraction/adverse effects MH - Tooth Socket/*drug effects MH - Tooth, Impacted/surgery EDAT- 2005/11/18 09:00 MHDA- 2006/05/19 09:00 CRDT- 2005/11/18 09:00 PHST- 2005/06/13 00:00 [received] PHST- 2005/07/26 00:00 [revised] PHST- 2005/08/03 00:00 [accepted] PHST- 2005/11/18 09:00 [pubmed] PHST- 2006/05/19 09:00 [medline] PHST- 2005/11/18 09:00 [entrez] AID - S0901-5027(05)00272-9 [pii] AID - 10.1016/j.ijom.2005.08.002 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2006 Apr;35(4):348-51. doi: 10.1016/j.ijom.2005.08.002. Epub 2005 Nov 9. PMID- 22046746 OWN - NLM STAT- MEDLINE DCOM- 20111206 LR - 20161125 IS - 0158-1570 (Print) IS - 0158-1570 (Linking) VI - 20 DP - 2010 Mar TI - Coronectomy as the treatment of choice in wisdom teeth showing radiographic signs of close proximity to inferior dental nerve. PG - 93-4 AB - The aim of the study is to compare the prevalence of post-operative inferior dental nerve (IDN) deficit after coronectomy with total removal of wisdom teeth showing specific radiographic signs of close proximity to IDN. A randomized clinical trial comparing total removal and coronectomy of wisdom tooth was conducted. Analyses of the correlations of IDN deficit and various radiographic signs of wisdom tooth roots showing close proximity to IDN were performed. Two radiographic signs were found to be positive predictors ofintra-operative IDN exposure. Specific radiographic signs or the presence of two or more radiographic signs are positive predictors of post-operative IDN deficit. The study concluded that darkening of the wisdom tooth root and presence of two or more specific signs in radiographs significantly increased the risk of IDN deficit in lower wisdom tooth surgery. Coronectomy can significantly reduce the prevalence of an IDN deficit in patients with lower wisdom teeth showing radiographic signs of close proximity to IDN. It also carries less surgical morbidities when compared with total removal of lower wisdom tooth. FAU - Leung, Yiu Yan AU - Leung YY AD - Faculty of Dentistry, The University of Hong Kong, Hong Kong. FAU - Cheung, Lim Kwong AU - Cheung LK LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Australia TA - Ann R Australas Coll Dent Surg JT - Annals of the Royal Australasian College of Dental Surgeons JID - 8006208 SB - D MH - Dry Socket/etiology MH - Follow-Up Studies MH - Forecasting MH - Humans MH - Mandible/surgery MH - Mandibular Nerve/diagnostic imaging MH - Molar, Third/diagnostic imaging/*surgery MH - Pain, Postoperative/etiology MH - Postoperative Complications/*prevention & control MH - *Radiography, Panoramic MH - Tooth Crown/diagnostic imaging/*surgery MH - *Tooth Extraction/adverse effects MH - Tooth Root/diagnostic imaging MH - *Trigeminal Nerve Injuries EDAT- 2010/03/01 00:00 MHDA- 2011/12/13 00:00 CRDT- 2011/11/04 06:00 PHST- 2011/11/04 06:00 [entrez] PHST- 2010/03/01 00:00 [pubmed] PHST- 2011/12/13 00:00 [medline] PST - ppublish SO - Ann R Australas Coll Dent Surg. 2010 Mar;20:93-4. PMID- 9549917 OWN - NLM STAT- MEDLINE DCOM- 19980423 LR - 20190719 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 184 IP - 4 DP - 1998 Feb 28 TI - A randomised trial of calcium alginate swabs to control blood loss in 3-5-year-old children. PG - 187-90 AB - OBJECTIVE: To compare the effectiveness of calcium alginate swabs and traditional cotton swabs in the control of blood loss after extraction of deciduous teeth from healthy children, aged 3-5 years, under general anaesthetic. DESIGN: Prospective, randomised clinical trial. SETTING: General anaesthetic suite in a dental teaching hospital. SUBJECTS: 101 patients were recruited to the study, comprising 50 randomised to be treated with cotton swabs and 51 with alginate swabs. INTERVENTIONS: Teeth were extracted under general anaesthesia and blood collected for measurement in order to compare blood loss using the two systems. MAIN OUTCOME MEASURES: The number of teeth extracted ranged from 1-14. The total blood loss ranged from 0.53-78.13 ml with a median of 12.9 ml. CONCLUSION: Calcium alginate swabs were not found to produce any clinical or statistical advantage over traditional cotton swabs in this surgical setting. FAU - Henderson, N J AU - Henderson NJ AD - Eastman Dental Institute for Oral Health Care Sciences, London. FAU - Crawford, P J AU - Crawford PJ FAU - Reeves, B C AU - Reeves BC LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Alginates) RN - 0 (Hemostatics) RN - 0 (Hexuronic Acids) RN - 8A5D83Q4RW (Glucuronic Acid) SB - D SB - IM CIN - Br Dent J. 1998 Feb 28;184(4):177. PMID: 9549914 CIN - Br Dent J. 1998 Jun 13;184(11):526. PMID: 9682543 MH - Alginates/*therapeutic use MH - Anesthesia, Dental/methods MH - Anesthesia, General/statistics & numerical data MH - Blood Loss, Surgical/*prevention & control MH - Blood Volume MH - Chi-Square Distribution MH - Child, Preschool MH - *Dental Care for Children MH - Dye Dilution Technique MH - Glucuronic Acid MH - Gossypium/therapeutic use MH - Hemostasis, Surgical/*instrumentation/methods MH - Hemostatics/*therapeutic use MH - Hexuronic Acids MH - Humans MH - Oral Hemorrhage/etiology/*prevention & control MH - Phytotherapy MH - Prospective Studies MH - Regression Analysis MH - Statistics, Nonparametric MH - Surgical Sponges MH - Tooth Extraction/*adverse effects MH - Tooth Root EDAT- 1998/04/29 00:00 MHDA- 1998/04/29 00:01 CRDT- 1998/04/29 00:00 PHST- 1998/04/29 00:00 [pubmed] PHST- 1998/04/29 00:01 [medline] PHST- 1998/04/29 00:00 [entrez] AID - 10.1038/sj.bdj.4809576 [doi] PST - ppublish SO - Br Dent J. 1998 Feb 28;184(4):187-90. doi: 10.1038/sj.bdj.4809576. PMID- 12946679 OWN - NLM STAT- MEDLINE DCOM- 20031204 LR - 20190916 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 41 IP - 4 DP - 2003 Aug TI - Re: Sugar A W et al. Can warfarin be continued during dental extraction? Results of a randomised controlled trial. Br J Oral Maxillofac Surg 2002; 40: 248-252. PG - 280 FAU - Gibbons, A J AU - Gibbons AJ FAU - Sugar, A W AU - Sugar AW LA - eng PT - Comment PT - Letter PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM CON - Br J Oral Maxillofac Surg. 2003 Apr;41(2):132. PMID: 12694713 MH - Anticoagulants/*therapeutic use MH - *Dental Care for Chronically Ill/economics MH - General Practice, Dental MH - Hospitalization/economics MH - Humans MH - International Normalized Ratio MH - Randomized Controlled Trials as Topic MH - *Tooth Extraction/economics MH - Warfarin/*therapeutic use EDAT- 2003/08/30 05:00 MHDA- 2003/12/05 05:00 CRDT- 2003/08/30 05:00 PHST- 2003/08/30 05:00 [pubmed] PHST- 2003/12/05 05:00 [medline] PHST- 2003/08/30 05:00 [entrez] AID - S0266435603001177 [pii] AID - 10.1016/s0266-4356(03)00117-7 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2003 Aug;41(4):280. doi: 10.1016/s0266-4356(03)00117-7. PMID- 3083002 OWN - NLM STAT- MEDLINE DCOM- 19860515 LR - 20190919 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 15 IP - 1 DP - 1986 Feb TI - Postoperative complications after surgical removal of mandibular third molars. Effects of penicillin V and chlorhexidine. PG - 25-9 AB - A random material of 112 patients, was investigated after surgical removal of impacted lower third molars. 2 experimental groups and 1 control group were studied. Prophylactic medication with penicillin V combined with preoperative rinsing using 0.2% chlorhexidine gluconate (Hibitane) was found to reduce postoperative symptoms, when compared with preoperative rinsing alone. In both cases, patients were compared with the control group. FAU - Krekmanov, L AU - Krekmanov L FAU - Nordenram, A AU - Nordenram A LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - R4KO0DY52L (Chlorhexidine) RN - Z61I075U2W (Penicillin V) SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Chlorhexidine/administration & dosage/*therapeutic use MH - Edema/etiology/physiopathology MH - Facial Pain/etiology/physiopathology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Penicillin V/administration & dosage/*therapeutic use MH - Postoperative Complications/prevention & control MH - *Premedication MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/etiology/physiopathology MH - Wound Healing EDAT- 1986/02/01 00:00 MHDA- 1986/02/01 00:01 CRDT- 1986/02/01 00:00 PHST- 1986/02/01 00:00 [pubmed] PHST- 1986/02/01 00:01 [medline] PHST- 1986/02/01 00:00 [entrez] AID - 10.1016/s0300-9785(86)80007-2 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1986 Feb;15(1):25-9. doi: 10.1016/s0300-9785(86)80007-2. PMID- 10759649 OWN - NLM STAT- MEDLINE DCOM- 20000502 LR - 20190831 IS - 0160-564X (Print) IS - 0160-564X (Linking) VI - 24 IP - 3 DP - 2000 Mar TI - Use of N-butyl-2-cyanoacrylate in oral surgery: biological and clinical evaluation. PG - 241-3 AB - N-butyl-2-cyanoacrylate based tissue adhesive, Tisuacryl, was employed as a nonsuture method for closing wounds in oral surgery. One hundred thirty patients were treated with the adhesive and 30 with suture. The surgical procedures were apicectomy, extraction of molars, and mucogingival grafting. The studied product was well tolerated by the tissue and permitted immediate hemostasis and normal healing of incisions. When Tisuacryl was used as dressing material for donor sites and mucosal ulcerations, pain relief was observed. FAU - Pérez, M AU - Pérez M AD - Clínica Estomatológica Docente de Bauta, Provincia Habana; and Centre of Biomaterials of Havana University, Havanna, Cuba. FAU - Fernández, I AU - Fernández I FAU - Márquez, D AU - Márquez D FAU - Bretaña, R M AU - Bretaña RM LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Artif Organs JT - Artificial organs JID - 7802778 RN - 0 (Analgesics) RN - 0 (Hemostatics) RN - 0 (Tissue Adhesives) RN - F8CEP82QNP (Enbucrilate) SB - IM MH - Adult MH - Analgesics/therapeutic use MH - Apicoectomy MH - Biological Dressings MH - Enbucrilate/*therapeutic use MH - Female MH - Follow-Up Studies MH - Gingiva/transplantation MH - Hemostatics/therapeutic use MH - Humans MH - Male MH - Molar/surgery MH - Mouth Mucosa/transplantation MH - *Oral Surgical Procedures MH - Oral Ulcer/drug therapy MH - Pain, Postoperative/drug therapy MH - Prospective Studies MH - Suture Techniques MH - Tissue Adhesives/*therapeutic use MH - Tooth Extraction MH - Wound Healing EDAT- 2000/04/12 09:00 MHDA- 2000/05/08 09:00 CRDT- 2000/04/12 09:00 PHST- 2000/04/12 09:00 [pubmed] PHST- 2000/05/08 09:00 [medline] PHST- 2000/04/12 09:00 [entrez] AID - aor6519 [pii] AID - 10.1046/j.1525-1594.2000.06519.x [doi] PST - ppublish SO - Artif Organs. 2000 Mar;24(3):241-3. doi: 10.1046/j.1525-1594.2000.06519.x. PMID- 8830203 OWN - NLM STAT- MEDLINE DCOM- 19961015 LR - 20201209 IS - 0379-0355 (Print) IS - 0379-0355 (Linking) VI - 17 IP - 5 DP - 1995 Jun TI - Reproducibility of postoperative courses after surgical removal of symmetrically impacted wisdom teeth. PG - 345-56 AB - The acute postoperative courses after bilateral ¿identical¿ surgical removals of symmetrically impacted third molars on two separate occasions were investigated in a study containing two separate trials. Both trials were conducted as open interpatient crossover trials. Codeine phosphate (50 mg), with assumed analgesic effect but with no known clinical antiinflammatory effect, was given 4 times daily for 3 days starting 2 h after surgery in one trial using 20 patients (mean age 22.7 years, 12 females/8 males) and starting 3 h after surgery in the other trial using 20 patients (mean age 23.0 years, 11 females/9 males). Identical surgical procedures were carried out by the same surgeon in the same patient. The study shows the mean postoperative time courses of pain intensity, sum pain intensity, and swelling to be similar after bilateral operations. Pain intensity difference scores as measures of analgesia suggested the influence of carryover effects with respect to the second operation, irrespective of drug starting time. Mouth opening ability was not similar on each occasion after bilateral surgery. It can be concluded that the carryover design in bilateral surgery is valid and useful with respect to testing drug effects on swelling. The bilateral third molar model also offers the ability to test clinically relevant multiple dose regimens in phase 3 trials. It should, however, be recognized that the bilateral third molar model is highly dependent on the skill of the surgeon and may thus be more difficult to complete than parallel group trials. FAU - Björnsson, G A AU - Björnsson GA AD - Department of Oral Surgery and Oral Medicine, University of Oslo, Norway. FAU - Bjørnland, T AU - Bjørnland T FAU - Skoglund, L A AU - Skoglund LA LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Spain TA - Methods Find Exp Clin Pharmacol JT - Methods and findings in experimental and clinical pharmacology JID - 7909595 RN - UX6OWY2V7J (Codeine) SB - IM MH - Adult MH - Clinical Competence/standards MH - Codeine/administration & dosage/*therapeutic use MH - Cross-Over Studies MH - European Continental Ancestry Group MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Postoperative Complications/*drug therapy MH - Reproducibility of Results MH - Tooth Extraction/*standards EDAT- 1995/06/01 00:00 MHDA- 1995/06/01 00:01 CRDT- 1995/06/01 00:00 PHST- 1995/06/01 00:00 [pubmed] PHST- 1995/06/01 00:01 [medline] PHST- 1995/06/01 00:00 [entrez] PST - ppublish SO - Methods Find Exp Clin Pharmacol. 1995 Jun;17(5):345-56. PMID- 1742266 OWN - NLM STAT- MEDLINE DCOM- 19920116 LR - 20190912 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 29 IP - 5 DP - 1991 Oct TI - The effect of pre-operative perioral skin preparation with aqueous povidone-iodine on the incidence of infection after third molar removal. PG - 336-7 AB - A study was carried out to measure the incidence of dry socket and wound infection following third molar removal under endotracheal general anaesthetic. One group of patients received pre-operative preparation of the perioral skin with a 10% solution of povidine-iodine, while the other received no skin preparation. Routine skin preparation imposes a risk of contact dermatitis and necessarily involves expense. In relation to postoperative wound infection, this practise was of no benefit. The results of this study provide evidence that skin preparation with povidine-iodine prior to third molar extractions should be discontinued. FAU - Loukota, R A AU - Loukota RA AD - Department of Oral and Maxillofacial Surgery, St James' University Hospital, Leeds. LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 140QMO216E (Metronidazole) RN - 85H0HZU99M (Povidone-Iodine) SB - D SB - IM MH - Administration, Cutaneous MH - Adult MH - Dry Socket/*etiology MH - Female MH - Humans MH - Incidence MH - Male MH - Metronidazole/therapeutic use MH - Molar, Third/*surgery MH - Povidone-Iodine/administration & dosage/*therapeutic use MH - *Preoperative Care MH - Surgical Wound Infection/*etiology MH - *Tooth Extraction/adverse effects EDAT- 1991/10/01 00:00 MHDA- 1991/10/01 00:01 CRDT- 1991/10/01 00:00 PHST- 1991/10/01 00:00 [pubmed] PHST- 1991/10/01 00:01 [medline] PHST- 1991/10/01 00:00 [entrez] AID - 10.1016/0266-4356(91)90122-l [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1991 Oct;29(5):336-7. doi: 10.1016/0266-4356(91)90122-l. PMID- 2197381 OWN - NLM STAT- MEDLINE DCOM- 19900824 LR - 20201209 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 48 IP - 8 DP - 1990 Aug TI - Double-blind comparison of meclofenamate sodium plus codeine, meclofenamate sodium, codeine, and placebo for relief of pain following surgical removal of third molars. PG - 785-90 AB - A single-dose, randomized, double-blind, parallel-treatment study was performed in 200 outpatients with acute pain caused by the surgical removal of impacted third molars. Meclofenamate 100 mg plus codeine 60 mg, meclofenamate 50 mg plus codeine 30 mg, meclofenamate 100 mg, codeine 60 mg, and placebo treatment groups were compared for sum of pain intensity differences, peak pain intensity difference, sum of pain relief scores, peak pain relief, number of observations at which pain was half relieved, overall evaluation of effectiveness, and time to remedication with a backup analgesic. Meclofenamate 100 mg plus codeine 60 mg was significantly more effective (P less than .005) than codeine 60 mg for all variables except number of observations at which pain was half relieved. Both meclofenamate-codeine combinations and meclofenamate 100 mg alone were significantly more effective (P less than .005) than placebo for all variables. Eleven adverse experiences were reported in 7 patients (3.5%); the most common was somnolence in 1 patient receiving meclofenamate 100 mg plus codeine 60 mg, in 2 treated with meclofenamate 50 mg plus codeine 30 mg, and in 1 treated with codeine 60 mg. FAU - Giglio, J A AU - Giglio JA AD - Department of Oral and Maxillofacial Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0566. FAU - Laskin, D M AU - Laskin DM LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (ortho-Aminobenzoates) RN - 48I5LU4ZWD (Meclofenamic Acid) RN - UX6OWY2V7J (Codeine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Codeine/*administration & dosage MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Linear Models MH - Male MH - Meclofenamic Acid/*administration & dosage MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Randomized Controlled Trials as Topic MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - ortho-Aminobenzoates/*administration & dosage EDAT- 1990/08/01 00:00 MHDA- 1990/08/01 00:01 CRDT- 1990/08/01 00:00 PHST- 1990/08/01 00:00 [pubmed] PHST- 1990/08/01 00:01 [medline] PHST- 1990/08/01 00:00 [entrez] AID - 0278-2391(90)90332-V [pii] AID - 10.1016/0278-2391(90)90332-v [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1990 Aug;48(8):785-90. doi: 10.1016/0278-2391(90)90332-v. PMID- 9574945 OWN - NLM STAT- MEDLINE DCOM- 19980630 LR - 20190909 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 85 IP - 4 DP - 1998 Apr TI - Perioperative use of 0.12% chlorhexidine gluconate for the prevention of alveolar osteitis: efficacy and risk factor analysis. PG - 381-7 AB - OBJECTIVES: The purposes of this study were to evaluate the use of 0.12% chlorhexidine gluconate as a prophylactic therapy for the prevention of alveolar osteitis and to further examine subject-based risk factors associated with alveolar osteitis. STUDY DESIGN: The trial was a randomized, double-blind, placebo-controlled, parallel-group study conducted among 279 subjects, each of whom required oral surgery for the removal of a minimum of one impacted mandibular third molar. Subjects were instructed to rinse twice daily with 15 ml of chlorhexidine or placebo mouthrinse for 30 seconds for 1 week before and 1 week after the surgical extractions. This regimen included a supervised presurgical rinse. Alveolar osteitis diagnosis was based on the subjective finding of increasing postoperative pain at the surgical site that was not relieved with mild analgesics, supported by clinical evidence of one or more of the following: loss of blood clot, necrosis of blood clot, and exposed alveolar bone. RESULTS: In comparison with use of the placebo mouthrinse, prophylactic use of the chlorhexidine mouthrinse resulted in statistically significant (p < 0.05) reductions in the incidence of alveolar osteitis. With chlorhexidine therapy, the subject- and extraction-based incidences of alveolar osteitis in the evaluable subset (271 subjects) were reduced, relative to placebo, by 38% and 44%, respectively. The corresponding odds ratios that describe the increased odds of experiencing alveolar osteitis in the placebo group were 1.87 and 2.05 for subject- and extraction-based analyses, respectively. In comparison with nonuse of oral contraceptives, the use of oral contraceptives in female subjects was related to a statistically significant increase in the incidence of alveolar osteitis (odds ratio = 1.92, p = 0.035). Relative to male subjects, the observed incidence of alveolar osteitis for female subjects not using oral contraceptives was not statistically significant (odds ratio = 1.18, p = 0.64). Smoking did not increase the incidence of alveolar osteitis relative to not smoking (odds ratio = 1.20, p = 0.33). CONCLUSIONS: These data confirm that the prophylactic use of 0.12% chlorhexidine gluconate mouthrinse results in a significant reduction in the incidence of alveolar osteitis after the extraction of impacted mandibular third molars. In addition, oral contraceptive use in females was confirmed to be a risk factor for the development of alveolar osteitis. FAU - Hermesch, C B AU - Hermesch CB AD - Department of General Dentistry, The University of Texas Health Science Center, San Antonio, USA. FAU - Hilton, T J AU - Hilton TJ FAU - Biesbrock, A R AU - Biesbrock AR FAU - Baker, R A AU - Baker RA FAU - Cain-Hamlin, J AU - Cain-Hamlin J FAU - McClanahan, S F AU - McClanahan SF FAU - Gerlach, R W AU - Gerlach RW LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anti-Infective Agents) RN - 0 (Contraceptives, Oral) RN - 0 (Mouthwashes) RN - 0 (Placebos) RN - MOR84MUD8E (chlorhexidine gluconate) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolar Process/pathology MH - Anti-Infective Agents/administration & dosage/*therapeutic use MH - Blood Coagulation MH - Chemoprevention MH - Chlorhexidine/administration & dosage/*analogs & derivatives/therapeutic use MH - Contraceptives, Oral/adverse effects MH - Double-Blind Method MH - Dry Socket/diagnosis/*prevention & control MH - Female MH - Humans MH - Incidence MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/surgery MH - Mouthwashes/*therapeutic use MH - Necrosis MH - Odds Ratio MH - Pain, Postoperative/diagnosis MH - Placebos MH - *Premedication MH - Risk Factors MH - Smoking/adverse effects MH - Tooth, Impacted/surgery EDAT- 1998/05/09 00:00 MHDA- 1998/05/09 00:01 CRDT- 1998/05/09 00:00 PHST- 1998/05/09 00:00 [pubmed] PHST- 1998/05/09 00:01 [medline] PHST- 1998/05/09 00:00 [entrez] AID - S1079-2104(98)90061-0 [pii] AID - 10.1016/s1079-2104(98)90061-0 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Apr;85(4):381-7. doi: 10.1016/s1079-2104(98)90061-0. PMID- 8180524 OWN - NLM STAT- MEDLINE DCOM- 19940615 LR - 20161123 IS - 1055-7601 (Print) IS - 1055-7601 (Linking) VI - 2 IP - 4 DP - 1993 Fall TI - An open comparative study of the analgesic effects of tenoxicam and diclofenac sodium after third molar surgery. PG - 217-22 AB - Tenoxicam and diclofenac sodium were compared as analgesics following the surgical removal of third molars. Twenty-five patients between the ages 17 and 29 years were randomly allocated into two groups. Patients in group A received a single intraoperative intravenous (i.v.) injection of 20 mg of tenoxicam followed by a 20-mg tablet given the evening after the operation; thereafter, one 20-mg tablet was given once daily for the next 6 days. Group B received a single intraoperative intramuscular injection of 75 mg of diclofenac sodium followed by a 50-mg tablet 4 to 6 hours postoperatively and during the evening; thereafter, a 50-mg tablet was taken three times daily for the next 6 days. Pain was postoperatively measured hourly for 4 hours and later in the evening. Pain was also measured in the mornings and evenings for the next 6 days. The highest pain scores were obtained 1 hour postoperatively for both groups. During the first 3 hours following administration, patients in the tenoxicam group experienced significantly more pain than those in the diclofenac group. Preoperatively, both treatments showed identical efficacy after 3 hours. It is therefore suggested that a 40-mg dose of i.v. tenoxicam should be administered at induction of anesthesia to achieve a higher level of analgesia in the immediate postoperative phase. FAU - Roelofse, J A AU - Roelofse JA AD - Division of Anaesthesia, University of Stellenbosch, Tygerberg, South Africa. FAU - van der Bijl, P AU - van der Bijl P FAU - Joubert, J J AU - Joubert JJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Anesth Pain Control Dent JT - Anesthesia & pain control in dentistry JID - 9207842 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 144O8QL0L1 (Diclofenac) RN - Z1R9N0A399 (tenoxicam) SB - D MH - Adolescent MH - Adult MH - *Analgesics MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Chi-Square Distribution MH - *Diclofenac MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Piroxicam/*analogs & derivatives MH - Premedication MH - Time Factors MH - Tooth Extraction EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] PST - ppublish SO - Anesth Pain Control Dent. 1993 Fall;2(4):217-22. PMID- 12694713 OWN - NLM STAT- MEDLINE DCOM- 20030807 LR - 20190916 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 41 IP - 2 DP - 2003 Apr TI - Re: Sugar AW et al. Can warfarin be continued during dental extraction? Results of a randomised controlled trial. Br J Oral Maxillofac Surg 2002; 40: 248-252. PG - 132 FAU - Sen, Pinaki AU - Sen P FAU - Sen, Romi AU - Sen R LA - eng PT - Comment PT - Letter PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM CON - Br J Oral Maxillofac Surg. 2002 Jun;40(3):248-52. PMID: 12054719 CIN - Br J Oral Maxillofac Surg. 2003 Aug;41(4):280. PMID: 12946679 MH - Anticoagulants/administration & dosage/*therapeutic use MH - Dental Service, Hospital MH - Humans MH - International Normalized Ratio MH - Randomized Controlled Trials as Topic MH - Risk Factors MH - *Tooth Extraction MH - Warfarin/administration & dosage/*therapeutic use EDAT- 2003/04/16 05:00 MHDA- 2003/08/09 05:00 CRDT- 2003/04/16 05:00 PHST- 2003/04/16 05:00 [pubmed] PHST- 2003/08/09 05:00 [medline] PHST- 2003/04/16 05:00 [entrez] AID - S0266435602002929 [pii] AID - 10.1016/s0266-4356(02)00292-9 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2003 Apr;41(2):132. doi: 10.1016/s0266-4356(02)00292-9. PMID- 7973552 OWN - NLM STAT- MEDLINE DCOM- 19941207 LR - 20161020 IS - 0256-2855 (Print) IS - 0256-2855 (Linking) VI - 104 IP - 10 DP - 1994 TI - [The surgical removal of the lower wisdom teeth. Is open follow-up care still up-to-date?]. PG - 1202-9 AB - The removal of lower wisdom teeth is one of the most common procedures in oral surgery. Postoperative complications have been reported in over 10% of the cases, of those being 8.5% due to infection. In our Department, the open wound healing method has been used routinely for more than 50 years. In this article we present a retrospective and a prospective study comparing the open and closed wound healing techniques after lower third molar removal. The retrospective study dealt with 908 consecutive cases of the year 1991 in which all postoperative complications were analysed. The prospective controlled randomized study dealt with 300 cases in which the open and the half closed wound treatment was compared. Preoperative data including the papillary bleeding index and the postoperative incidence of infections were analysed. In the open wound healing group, a complication rate of 3%, with less than 1% being infectious, was observed. In the group where a semi-closed procedure was performed, a complication rate of more than 13% with 6% infections was found. It could be demonstrated that poor oral hygiene influences the postoperative infection rate, especially in cases where the semi-closed wound healing was used, whereas open wound healing is less affected by the status of oral hygiene. In both methods approximately three postoperative consultations were necessary. Based on these results, the open wound healing method after surgical removal of lower wisdom teeth is advocated. FAU - Pajarola, G F AU - Pajarola GF AD - Klinik und Poliklinik für Kiefer- und Gesichtschirurgie, Universität Zürich. FAU - Sailer, H F AU - Sailer HF LA - ger PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Operative Entfernung unterer Weisheitszähne. Ist die offene Nachbehandlung noch modern? PL - Switzerland TA - Schweiz Monatsschr Zahnmed JT - Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia JID - 8709597 SB - D SB - IM MH - Adolescent MH - Adult MH - Age Distribution MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - *Postoperative Care/methods/statistics & numerical data MH - Postoperative Complications/epidemiology/therapy MH - Prospective Studies MH - Retrospective Studies MH - Sex Distribution MH - Switzerland/epidemiology MH - *Tooth Extraction MH - Tooth, Impacted/epidemiology/surgery EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] PST - ppublish SO - Schweiz Monatsschr Zahnmed. 1994;104(10):1202-9. PMID- 3472476 OWN - NLM STAT- MEDLINE DCOM- 19870528 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 34 IP - 1 DP - 1987 Jan-Feb TI - Long-acting analgesic or long-acting local anesthetic in controlling immediate postoperative pain after lower third molar surgery. PG - 6-9 AB - In a double-blind crossover study, the effect on postoperative pain of lidocaine plus diflunisal was compared with that of bupivacaine and placebo. Forty-eight patients with bilateral impactions of lower third molars had these removed on two occasions four weeks apart. One pain-control regimen was used on one occasion and the alternate on the second. The pain intensity was indicated on a visual analog scale at 2, 3, 4, 5, and 6 hours postoperatively. The pain values for the first postoperative hours were higher for the lidocaine diflunisal combination, whereas after 5 hours the opposite was true. Significantly more patients preferred the combination of lidocaine and diflunisal. Three patients reported fatigue postoperatively during the day of surgery, which they attributed to the operation and not to the analgesics used. FAU - Rosenquist, J B AU - Rosenquist JB FAU - Nystrom, E AU - Nystrom E LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Salicylates) RN - 7C546U4DEN (Diflunisal) RN - 98PI200987 (Lidocaine) RN - Y8335394RO (Bupivacaine) SB - D MH - Adolescent MH - Adult MH - Bupivacaine/*pharmacology MH - Diflunisal/*pharmacology MH - Double-Blind Method MH - Female MH - Humans MH - Lidocaine/*pharmacology MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*prevention & control MH - Salicylates/*pharmacology MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery PMC - PMC2186224 EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] PST - ppublish SO - Anesth Prog. 1987 Jan-Feb;34(1):6-9. PMID- 2563688 OWN - NLM STAT- MEDLINE DCOM- 19890406 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 36 IP - 1 DP - 1989 TI - The efficacy of benorylate in postoperative dental pain. PG - 35-8 AB - The efficacy of a single pre-operative dose of benorylate (4 g) was determined in a double-blind, randomized, placebo-controlled parallel study in patients undergoing removal of a single impacted lower third molar. Patients treated with benorylate 4 g reported significantly less pain between 3-6 h after dosage than those treated with placebo. Overall pain scores at 6 h were significantly less in the benorylate group than the placebo group. However, overall pain scores at 12 h did not differ significantly between treatment groups. It is concluded from this study that a single dose of benorylate 4 g given immediately prior to the removal of an impacted lower third molar provides limited pain control during the postoperative period. FAU - Moore, U AU - Moore U AD - Department of Oral Surgery, Dental School, Newcastle upon Tyne, UK. FAU - Seymour, R A AU - Seymour RA FAU - Williams, F M AU - Williams FM FAU - Nicholson, E AU - Nicholson E FAU - Rawlins, M D AU - Rawlins MD LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Salicylates) RN - 362O9ITL9D (Acetaminophen) SB - IM MH - Acetaminophen/therapeutic use MH - Adolescent MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Random Allocation MH - Salicylates/*therapeutic use MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1989/01/01 00:00 MHDA- 1989/01/01 00:01 CRDT- 1989/01/01 00:00 PHST- 1989/01/01 00:00 [pubmed] PHST- 1989/01/01 00:01 [medline] PHST- 1989/01/01 00:00 [entrez] AID - 10.1007/BF00561020 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1989;36(1):35-8. doi: 10.1007/BF00561020. PMID- 9422907 OWN - NLM STAT- MEDLINE DCOM- 19980115 LR - 20190515 IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 79 IP - 5 DP - 1997 Nov TI - Pre-emptive analgesia using local anaesthesia: a study in bilaterally symmetrical surgery. PG - 657-9 AB - Two studies were carried out in patients undergoing bilaterally symmetrical lower third molar surgery under general anaesthesia. In the first study observations were carried out in 40 patients, using McGill pain questionnaires and visual analogue scales (VAS), to assess the variation in pain intensity between the two sides in each individual on the morning after surgery. The within-patient variation in pain intensity indicated that a sample size exceeding 30 was required to show a difference of more than 10 mm on the VAS and achieve a power of 90% at the 5% level of significance. The second study was carried out to determine if local anaesthesia administered before rather than after tooth removal rendered any benefit. Each of the 38 patients acted as their own control; one side was allocated randomly to receive the local anaesthetic before operation and the other side after operation. The difference in pain between the pretreated and post-treated sides in each individual was assessed using a McGill pain questionnaire on the morning after surgery in addition to two VAS (one for each operation side) after operation, at 6 h, 1 and 6 days after surgery. There were no significant differences in pain at any time using any of the above methods. FAU - Campbell, W I AU - Campbell WI AD - Department of Anaesthetics, Ulster Hospital, Dundonald. FAU - Kendrick, R W AU - Kendrick RW LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Anesthetics, Local) RN - Y8335394RO (Bupivacaine) SB - IM MH - Adolescent MH - Adult MH - Analgesia/*methods MH - Anesthesia, Dental MH - Anesthesia, General MH - Anesthetics, Local/*therapeutic use MH - Bupivacaine/therapeutic use MH - Double-Blind Method MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - *Tooth Extraction EDAT- 1998/01/10 00:00 MHDA- 1998/01/10 00:01 CRDT- 1998/01/10 00:00 PHST- 1998/01/10 00:00 [pubmed] PHST- 1998/01/10 00:01 [medline] PHST- 1998/01/10 00:00 [entrez] AID - S0007-0912(17)39796-9 [pii] AID - 10.1093/bja/79.5.657 [doi] PST - ppublish SO - Br J Anaesth. 1997 Nov;79(5):657-9. doi: 10.1093/bja/79.5.657. PMID- 2358942 OWN - NLM STAT- MEDLINE DCOM- 19900731 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 48 IP - 7 DP - 1990 Jul TI - A comparison of preoperative and postoperative naproxen sodium for suppression of postoperative pain. PG - 674-8 AB - Using a within-subject, crossover experimental design, this study compared the efficacies of a nonsteroidal anti-inflammatory drug, naproxen sodium, 550 mg, administered either 30 minutes preoperatively or 30 minutes postoperatively to 36 patients undergoing the removal of impacted third molar teeth. Pain intensity was assessed postoperatively for 8 hours. Treatment with naproxen sodium, 550 mg, 30 minutes following completion of surgery was just as effective as presurgical administration in controlling postoperative pain. Administration of naproxen sodium in the immediate postoperative period may be indicated for optimum postoperative analgesia for patients in whom preoperative oral intake is contraindicated. FAU - Sisk, A L AU - Sisk AL AD - Department of Oral and Maxillofacial Surgery, Medical College of Georgia School of Dentistry, Augusta 30912-1270. FAU - Grover, B J AU - Grover BJ LA - eng GR - DE08124-01/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 57Y76R9ATQ (Naproxen) SB - AIM SB - D SB - IM MH - Adolescent MH - Binomial Distribution MH - Chi-Square Distribution MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Naproxen/*administration & dosage MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Postoperative Care MH - Premedication MH - Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1990/07/01 00:00 MHDA- 1990/07/01 00:01 CRDT- 1990/07/01 00:00 PHST- 1990/07/01 00:00 [pubmed] PHST- 1990/07/01 00:01 [medline] PHST- 1990/07/01 00:00 [entrez] AID - 0278-2391(90)90048-7 [pii] AID - 10.1016/0278-2391(90)90048-7 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1990 Jul;48(7):674-8. doi: 10.1016/0278-2391(90)90048-7. PMID- 15346369 OWN - NLM STAT- MEDLINE DCOM- 20041007 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 62 IP - 9 DP - 2004 Sep TI - Simultaneous removal of third molars during sagittal split osteotomies: the case against. PG - 1147-9 FAU - Schwartz, Harry C AU - Schwartz HC AD - Southern California Permanente Medical Group, USA. HCShwartz@scal.kp.org LA - eng PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM CIN - J Oral Maxillofac Surg. 2004 Sep;62(9):1144-6. PMID: 15346368 MH - Humans MH - Intraoperative Complications MH - Mandible/*surgery MH - Mandibular Fractures/etiology MH - Molar, Third/*surgery MH - Osteotomy/*methods MH - Randomized Controlled Trials as Topic MH - Tooth Extraction/methods MH - Tooth, Impacted/*surgery EDAT- 2004/09/04 05:00 MHDA- 2004/10/08 09:00 CRDT- 2004/09/04 05:00 PHST- 2004/09/04 05:00 [pubmed] PHST- 2004/10/08 09:00 [medline] PHST- 2004/09/04 05:00 [entrez] AID - S0278239104006317 [pii] AID - 10.1016/j.joms.2004.04.015 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2004 Sep;62(9):1147-9. doi: 10.1016/j.joms.2004.04.015. PMID- 17482846 OWN - NLM STAT- MEDLINE DCOM- 20070723 LR - 20070619 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 104 IP - 1 DP - 2007 Jul TI - Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different intensity targets. PG - e18-21 AB - OBJECTIVE: To evaluate whether or not it is possible to perform oral surgery in patients on oral anticoagulant therapy (OAT) without stopping treatment. STUDY DESIGN: A prospective randomized open-label study was designed to evaluate the outcome of oral surgery in patients on OAT, operated upon in conditions of reduced international normalized ratio (INR), compared with patients maintained in their usual therapeutic ranges of the prothrombin time INR. The INR target in the group with reduced OAT was 1.8, and the INR target of the group without reduced OAT was 2.5 or more in carriers of artificial valves. RESULTS: One hundred thirty-one patients on OAT were randomized to reduced anticoagulation or to full anticoagulation, and 511 teeth were extracted by the same surgeon. Mild bleeding, but excessive enough to warrant adoption of supplementary local hemostatic measures, was observed in 10 cases (15.1%) in the reduced dosage group and in 6 cases (9.2%) in the unmodified dosage group, which was a nonsignificant difference. There were no thrombotic complications in either group. CONCLUSIONS: This randomized study shows that, using simple measures for local hemostasis, it is not necessary to reduce OAT in patients undergoing routine dental extractions. FAU - Sacco, R AU - Sacco R AD - Istituto Stomatologico Italiano, Milan, Italy. rsacco@tiscalinet.it FAU - Sacco, M AU - Sacco M FAU - Carpenedo, M AU - Carpenedo M FAU - Mannucci, P M AU - Mannucci PM LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20070507 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anticoagulants) SB - D SB - IM MH - Administration, Oral MH - Adult MH - Aged MH - Aged, 80 and over MH - Anticoagulants/*adverse effects MH - Chi-Square Distribution MH - Female MH - Hemostasis, Surgical/methods MH - Humans MH - International Normalized Ratio/*standards MH - Male MH - Middle Aged MH - Oral Surgical Procedures/*adverse effects MH - Postoperative Hemorrhage/*etiology/prevention & control MH - Prospective Studies MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects MH - Treatment Outcome EDAT- 2007/05/08 09:00 MHDA- 2007/07/24 09:00 CRDT- 2007/05/08 09:00 PHST- 2006/05/26 00:00 [received] PHST- 2006/11/28 00:00 [revised] PHST- 2006/11/29 00:00 [accepted] PHST- 2007/05/08 09:00 [pubmed] PHST- 2007/07/24 09:00 [medline] PHST- 2007/05/08 09:00 [entrez] AID - S1079-2104(07)00029-7 [pii] AID - 10.1016/j.tripleo.2006.12.035 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul;104(1):e18-21. doi: 10.1016/j.tripleo.2006.12.035. Epub 2007 May 7. PMID- 1873746 OWN - NLM STAT- MEDLINE DCOM- 19910925 LR - 20071115 IS - 0709-8936 (Print) IS - 0709-8936 (Linking) VI - 57 IP - 7 DP - 1991 Jul TI - The effects of the helium-neon laser on postsurgical discomfort: a pilot study. PG - 584-6 AB - It has been postulated that low-energy lasers (soft lasers) have analgesic capabilities. European investigators who have worked with these lasers have tried to explain this phenomenon as an interference with the mediation of the pain message and/or the stimulation of endorphin production. There does not appear, however, to be much well-controlled research to support these claims. This study has examined the effect of the helium-neon laser on post-surgical discomfort. Fifteen patients who had surgical removal of bilaterally symmetrical mandibular third molars were evaluated. Laser therapy was applied to one side of each patient's mouth with the other side serving as the control. A similar technique of application, without activation of the laser beam, was utilized on the control side. This study has demonstrated that the helium-neon laser (632.8 nanometre (nm) at 10 milliwatt (mW), when applied to the surgical site for three minutes immediately following third molar surgery, reduced postoperative pain on the day of surgery and on the first postoperative day. This finding was statistically significant. FAU - Clokie, C AU - Clokie C AD - Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, McGill University, Montreal. FAU - Bentley, K C AU - Bentley KC FAU - Head, T W AU - Head TW LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Canada TA - J Can Dent Assoc JT - Journal (Canadian Dental Association) JID - 7907605 SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Child MH - Female MH - Humans MH - *Laser Therapy MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Pilot Projects EDAT- 1991/07/01 00:00 MHDA- 1991/07/01 00:01 CRDT- 1991/07/01 00:00 PHST- 1991/07/01 00:00 [pubmed] PHST- 1991/07/01 00:01 [medline] PHST- 1991/07/01 00:00 [entrez] PST - ppublish SO - J Can Dent Assoc. 1991 Jul;57(7):584-6. PMID- 9537731 OWN - NLM STAT- MEDLINE DCOM- 19980519 LR - 20190909 IS - 0001-6357 (Print) IS - 0001-6357 (Linking) VI - 56 IP - 1 DP - 1998 Feb TI - The effect of locally applied gauze drain impregnated with chlortetracycline ointment in mandibular third-molar surgery. PG - 25-9 AB - A prospective randomized crossover, within-patient, controlled study was performed in 26 healthy patients to test the effect of the prophylactic local use of gauze drain impregnated with chlortetracycline (Aureomycin 3%, Lederle) ointment on postoperative alveolitis formation after surgical removal of 52 bilaterally impacted mandibular third molars. The teeth were removed on two separate occasions; on one side drain was inserted in the socket, and on the other side no drain treatment was used for control. The influence on postoperative pain, swelling, and mouth opening ability was investigated. The results indicated a statistically significant reduction (P = 0.02) in the incidence of postoperative inflammatory complications, defined as postoperative alveolitis, from 35% in the no-drain group to 4% in the drain group. No statistically significant difference was found between the two treatment methods with regard to pain and mouth opening reduction. There was a significant difference between the drain and no-drain treatment with regard to swelling on the 1st postoperative day in favor of the no-drain method. It is concluded that insertion of a chlortetracycline-impregnated drain may be an effective method for reducing postoperative alveolitis formation but has no beneficial effect on pain, swelling, and mouth opening reduction after impacted mandibular third-molar surgery. FAU - Akota, I AU - Akota I AD - Department of Oral Surgery and Oral Medicine, Faculty of Odontology, University of Oslo, Norway. FAU - Alvsaker, B AU - Alvsaker B FAU - Bjørnland, T AU - Bjørnland T LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Acta Odontol Scand JT - Acta odontologica Scandinavica JID - 0370344 RN - 0 (Anti-Bacterial Agents) RN - 0 (Ointments) RN - WCK1KIQ23Q (Chlortetracycline) SB - D SB - IM MH - Administration, Topical MH - Adult MH - Anti-Bacterial Agents/administration & dosage/*therapeutic use MH - Chemoprevention MH - Chlortetracycline/administration & dosage/*therapeutic use MH - Cross-Over Studies MH - Drainage/*instrumentation MH - Dry Socket/prevention & control MH - Edema/prevention & control MH - Equipment Design MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - Male MH - Mandible/physiopathology/*surgery MH - Molar, Third/*surgery MH - Mouth Diseases/prevention & control MH - Movement MH - Ointments MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/prevention & control MH - Prospective Studies MH - Surgical Sponges MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/*surgery EDAT- 1998/04/16 00:00 MHDA- 1998/04/16 00:01 CRDT- 1998/04/16 00:00 PHST- 1998/04/16 00:00 [pubmed] PHST- 1998/04/16 00:01 [medline] PHST- 1998/04/16 00:00 [entrez] AID - 10.1080/000163598423027 [doi] PST - ppublish SO - Acta Odontol Scand. 1998 Feb;56(1):25-9. doi: 10.1080/000163598423027. PMID- 2407660 OWN - NLM STAT- MEDLINE DCOM- 19900405 LR - 20201211 IS - 0020-6539 (Print) IS - 0020-6539 (Linking) VI - 40 IP - 1 DP - 1990 Feb TI - A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars. PG - 31-6 AB - The effect of helium-neon (He-Ne) laser on the prevention of pain, swelling and trismus following the removal of an impacted third molar was studied in 100 patients randomly allocated to receive He-Ne laser, ibuprofen or placebo in a prospective double-blind parallel clinical trial. Trismus was significantly reduced in the He-Ne laser and ibuprofen treatment groups. Pain was significantly less in the ibuprofen group with regard to He-Ne laser and placebo groups. Swelling was the same in the three treatment groups. FAU - Carrillo, J S AU - Carrillo JS AD - Departamento de Profilaxis, Odontopediatria y Ortodonica, Facultad de Odontologia, Universidad Complutense, Madrid, Spain. FAU - Calatayud, J AU - Calatayud J FAU - Manso, F J AU - Manso FJ FAU - Barberia, E AU - Barberia E FAU - Martinez, J M AU - Martinez JM FAU - Donado, M AU - Donado M LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Int Dent J JT - International dental journal JID - 0374714 RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Edema/prevention & control MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - *Laser Therapy MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control EDAT- 1990/02/01 00:00 MHDA- 1990/02/01 00:01 CRDT- 1990/02/01 00:00 PHST- 1990/02/01 00:00 [pubmed] PHST- 1990/02/01 00:01 [medline] PHST- 1990/02/01 00:00 [entrez] PST - ppublish SO - Int Dent J. 1990 Feb;40(1):31-6. PMID- 21495857 OWN - NLM STAT- MEDLINE DCOM- 20111101 LR - 20110510 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 29 IP - 5 DP - 2011 May TI - Blue-violet light emitting diode (LED) irradiation immediately controls socket bleeding following tooth extraction: clinical and electron microscopic observations. PG - 333-8 LID - 10.1089/pho.2010.2856 [doi] AB - OBJECTIVE: Bleeding control is a major concern during dental surgery. A novel photocoagulation method using an irradiating blue-violet light emitting diode (LED) was investigated. BACKGROUND: Some dental light-curving units can emit blue-violet wavelengths around 380-515 nm with two peaks (410 nm and 470 nm). These wavelengths can cover the maximum absorption spectra of hemoglobin (430 nm). MATERIALS AND METHODS: Blue-violet LED 380-515 nm, 750 mW/cm(2), 10 sec (7.5 J/cm(2)) was used. Irradiation was performed for 10 sec or an additional 10 sec for 10 cases of tooth extraction at a distance of 1 cm from the socket. Bleeding was stopped by conventional roll pressure in another five cases as a control. Bleeding time for both procedures was measured. A Mann-Whitney U test was used for statistical analysis. In vitro transmission electron microscope (TEM) studies were performed to clarify the mechanism of hemostasis by blue-violet LED irradiation. RESULTS: Irradiation with the blue-violet LED yielded immediate hemostasis of the socket. Five cases showed coagulation within the first 10 sec, and another five cases required an additional 10 sec to fully control the bleeding. In contrast, the conventional method required 2-5 min (median 180 sec) to obtain hemostasis. The difference between the time required to stop the bleeding in the two methods was found to be statistically significant (p = 0.0014). A week later, the LED-irradiated sockets were healed uneventfully with epithelial covering. TEM showed the formation of a thin amorphous layer and an adjacent agglutination of platelets and other cellular elements under the layer at the interface of the irradiated blood. CONCLUSION: Blue-violet LED irradiation of bleeding sockets caused immediate clot formation and hemostasis. This procedure was safe and reliable and showed no adverse effects. FAU - Ishikawa, Isao AU - Ishikawa I AD - Institute of Advanced Biomedical Engineering and Science, Tokyo, Japan . FAU - Okamoto, Tomohiro AU - Okamoto T FAU - Morita, Seigo AU - Morita S FAU - Shiramizu, Fumika AU - Shiramizu F FAU - Fuma, Yoshihiro AU - Fuma Y FAU - Ichinose, Shizuko AU - Ichinose S FAU - Okano, Teruo AU - Okano T FAU - Ando, Tomohiro AU - Ando T LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110415 PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Oral Hemorrhage/etiology/*prevention & control MH - *Phototherapy MH - Postoperative Hemorrhage/etiology/*prevention & control MH - Tooth Extraction/*adverse effects MH - Tooth Socket EDAT- 2011/04/19 06:00 MHDA- 2011/11/02 06:00 CRDT- 2011/04/19 06:00 PHST- 2011/04/19 06:00 [entrez] PHST- 2011/04/19 06:00 [pubmed] PHST- 2011/11/02 06:00 [medline] AID - 10.1089/pho.2010.2856 [doi] PST - ppublish SO - Photomed Laser Surg. 2011 May;29(5):333-8. doi: 10.1089/pho.2010.2856. Epub 2011 Apr 15. PMID- 1745508 OWN - NLM STAT- MEDLINE DCOM- 19920115 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 72 IP - 5 DP - 1991 Nov TI - Evaluation of 0.12% chlorhexidine rinse on the prevention of alveolar osteitis. PG - 524-6 AB - A double-blind study evaluated the ability of 0.12% chlorhexidine rinse to decrease the incidence of localized alveolar osteitis after the removal of mandibular third molar teeth. One hundred sixty extraction sites in 80 patients were evaluated. A statistically significant decrease in the incidence of dry socket was seen in patients using the chlorhexidine rinse with no significant adverse reactions. Thus a 0.12% chlorhexidine rinse is shown to be an effective means of decreasing alveolar osteitis that may follow removal of third molar teeth. FAU - Ragno, J R Jr AU - Ragno JR Jr AD - Dental Clinic, Hinesville, Ga. FAU - Szkutnik, A J AU - Szkutnik AJ LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adult MH - Chlorhexidine/*therapeutic use MH - Double-Blind Method MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Mandibular Diseases/prevention & control MH - Molar, Third/*surgery EDAT- 1991/11/11 19:15 MHDA- 2001/03/28 10:01 CRDT- 1991/11/11 19:15 PHST- 1991/11/11 19:15 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1991/11/11 19:15 [entrez] AID - 10.1016/0030-4220(91)90487-w [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1991 Nov;72(5):524-6. doi: 10.1016/0030-4220(91)90487-w. PMID- 2597658 OWN - NLM STAT- MEDLINE DCOM- 19900202 LR - 20190912 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 27 IP - 6 DP - 1989 Dec TI - The effect of dexamethasone on neurapraxia following third molar surgery. PG - 477-80 AB - A double blind, controlled trial was undertaken to assess the effect of intra-muscular dexamethasone on neurapraxia following the surgical removal of mandibular third molars. No significant difference was found 24 h post-operatively between a control group and a group given dexamethasone. FAU - Von Arx, D P AU - Von Arx DP AD - Department of Oral and Maxillofacial Surgery, Kings College Hospital, London. FAU - Simpson, M T AU - Simpson MT LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Child MH - Dexamethasone/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - *Lingual Nerve MH - Male MH - *Mandibular Nerve MH - Middle Aged MH - Molar, Third/*surgery MH - Neural Conduction MH - Paresthesia/*prevention & control MH - Random Allocation MH - Sensation MH - Tooth Extraction/*adverse effects EDAT- 1989/12/01 00:00 MHDA- 1989/12/01 00:01 CRDT- 1989/12/01 00:00 PHST- 1989/12/01 00:00 [pubmed] PHST- 1989/12/01 00:01 [medline] PHST- 1989/12/01 00:00 [entrez] AID - 10.1016/s0266-4356(89)80005-1 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1989 Dec;27(6):477-80. doi: 10.1016/s0266-4356(89)80005-1. PMID- 17157478 OWN - NLM STAT- MEDLINE DCOM- 20070409 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 36 IP - 2 DP - 2007 Feb TI - A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study. PG - 123-7 AB - Diflunisal and lornoxicam are currently available non-steroidal anti-inflammatory drugs (NSAIDs) that have been shown to be effective to various degrees in pain relief when administered either pre-emptively or postoperatively. The pre-emptive analgesic efficacy of diflunisal 1000 mg was compared with that of lornoxicam 16 mg in 40 ASA I patients undergoing surgical removal of bilateral impacted third molars. The impacted third molar teeth on one side were removed at the first surgical appointment using one of the two drug regimens being assessed and the teeth on the contralateral side were removed at a second appointment using the alternate drug regimen; all operations were performed by the same surgeon. Acetaminophen up to 2000 mg daily was provided as rescue medication. The postoperative rescue analgesic consumption was recorded and pain scores were evaluated with a visual analogue scale at 2, 4, 6, 12 and 24h postoperatively. No statistically significant differences were found between groups with respect to rescue analgesic consumption and postoperative pain scores. Pre-emptive administration of both NSAIDs proved to be effective in the management of pain following the surgical removal of impacted third molar teeth. FAU - Pektas, Z O AU - Pektas ZO AD - Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Baskent University, Ankara, Turkey. opektas@baskent-adn.edu.tr FAU - Sener, M AU - Sener M FAU - Bayram, B AU - Bayram B FAU - Eroglu, T AU - Eroglu T FAU - Bozdogan, N AU - Bozdogan N FAU - Donmez, A AU - Donmez A FAU - Arslan, G AU - Arslan G FAU - Uckan, S AU - Uckan S LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20061208 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Drug Combinations) RN - 13T4O6VMAM (Piroxicam) RN - 7C546U4DEN (Diflunisal) RN - ER09126G7A (lornoxicam) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*therapeutic use MH - Cross-Over Studies MH - Diflunisal/*therapeutic use MH - Drug Combinations MH - Facial Pain/*prevention & control MH - Humans MH - Middle Aged MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Piroxicam/*analogs & derivatives/therapeutic use MH - Preoperative Care MH - Prospective Studies MH - Single-Blind Method MH - Tooth Extraction EDAT- 2006/12/13 09:00 MHDA- 2007/04/10 09:00 CRDT- 2006/12/13 09:00 PHST- 2006/04/04 00:00 [received] PHST- 2006/08/29 00:00 [revised] PHST- 2006/10/17 00:00 [accepted] PHST- 2006/12/13 09:00 [pubmed] PHST- 2007/04/10 09:00 [medline] PHST- 2006/12/13 09:00 [entrez] AID - S0901-5027(06)00446-2 [pii] AID - 10.1016/j.ijom.2006.10.005 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2007 Feb;36(2):123-7. doi: 10.1016/j.ijom.2006.10.005. Epub 2006 Dec 8. PMID- 7026258 OWN - NLM STAT- MEDLINE DCOM- 19811215 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 20 IP - 3 DP - 1981 TI - Pharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain. PG - 215-8 AB - A double-blind, randomised, crossover trial was undertaken to compare the analgesic effects of a single dose of paracetamol (1000 mg i.v.) with placebo in the immediate post-operative period following removal of impacted lower third molars. There was no significant difference in the pain relief between paracetamol and placebo in the first hour following injection. Thereafter, there was significantly less pain (P less than 0.05) after treatment with paracetamol than after placebo. Plasma concentrations of paracetamol were measured and pharmacokinetic variables were determined. Over the four hour period of investigation there was no clear relationship between analgesia and paracetamol concentration in either central or peripheral compartments. FAU - Seymour, R A AU - Seymour RA FAU - Rawlins, M D AU - Rawlins MD LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Analgesics) RN - 362O9ITL9D (Acetaminophen) SB - IM MH - Acetaminophen/*administration & dosage/blood/metabolism MH - *Analgesics MH - Clinical Trials as Topic MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intravenous MH - Kinetics MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction EDAT- 1981/01/01 00:00 MHDA- 1981/01/01 00:01 CRDT- 1981/01/01 00:00 PHST- 1981/01/01 00:00 [pubmed] PHST- 1981/01/01 00:01 [medline] PHST- 1981/01/01 00:00 [entrez] AID - 10.1007/BF00544600 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1981;20(3):215-8. doi: 10.1007/BF00544600. PMID- 9924222 OWN - NLM STAT- MEDLINE DCOM- 19990205 LR - 20190515 IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 81 IP - 4 DP - 1998 Oct TI - Local anaesthetic infiltration for surgical exodontia of third molar teeth: a double-blind study comparing bupivacaine infiltration with i.v. ketorolac. PG - 511-4 AB - We studied 40 patients undergoing surgical removal of at least two third molar teeth under general anaesthesia. Patients were allocated randomly to one of two groups: group B (n = 20) received bupivacaine up to 2 mg kg-1, infiltrated around the inferior alveolar nerves bilaterally, and group K (n = 20) received ketorolac 10 mg i.v. at the start of surgery. There were no significant differences between the two groups in postoperative pain scores measured at 1 h using a visual analogue scale. Group K had a significantly lower incidence of side effects related to intraoral anaesthesia. Swallowing, speech and oral continence were significantly better. Group K scored higher for overall patient satisfaction, measured using a visual analogue scale. We failed to demonstrate any difference in early postoperative recovery (coughing, laryngospasm, stridor or arterial oxygen desaturation) between the groups. We conclude that the use of 0.5% bupivacaine infiltration was no more effective than a single 10-mg injection of ketorolac while giving rise to a higher rate of "minor" airway complications and lower patient acceptability. FAU - Mellor, D J AU - Mellor DJ AD - Leeds General Infirmary. FAU - Mellor, A H AU - Mellor AH FAU - McAteer, E M AU - McAteer EM LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anesthetics, Local) RN - D8K2JPN18B (Tolmetin) RN - Y8335394RO (Bupivacaine) RN - YZI5105V0L (Ketorolac) SB - IM MH - Adult MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthesia, Dental MH - Anesthesia, General MH - Anesthetics, Local/adverse effects/therapeutic use MH - Bupivacaine/adverse effects/*therapeutic use MH - Double-Blind Method MH - Humans MH - Ketorolac MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Patient Satisfaction MH - Tolmetin/*analogs & derivatives/therapeutic use MH - *Tooth Extraction EDAT- 1999/01/30 00:00 MHDA- 1999/01/30 00:01 CRDT- 1999/01/30 00:00 PHST- 1999/01/30 00:00 [pubmed] PHST- 1999/01/30 00:01 [medline] PHST- 1999/01/30 00:00 [entrez] AID - S0007-0912(17)39538-7 [pii] AID - 10.1093/bja/81.4.511 [doi] PST - ppublish SO - Br J Anaesth. 1998 Oct;81(4):511-4. doi: 10.1093/bja/81.4.511. PMID- 9077048 OWN - NLM STAT- MEDLINE DCOM- 19970430 LR - 20201209 IS - 0020-7144 (Print) IS - 0020-7144 (Linking) VI - 45 IP - 2 DP - 1997 Apr TI - Preoperative hypnotic techniques reduce consumption of analgesics after surgical removal of third mandibular molars: a brief communication. PG - 102-8 AB - The effects of hypnosis in connection with surgery have been described in many clinical publications, but few controlled studies have been published. The aim of the present study was to evaluate the effects of preoperative hypnotic techniques used by patients planned for surgical removal of third mandibular molars. The patients were randomly assigned to an experimental (hypnotic techniques) or a control (no hypnotic techniques) group. During the week before the surgery, the experimental group listened to an audiotape containing a hypnotic relaxation induction. Posthypnotic suggestions of healing and recovery were given on the tape together with advice regarding ways to achieve control over stress and pain. The control group received no hypnotic intervention. Only one surgeon who was not aware of patient group assignments performed all the operations. Thirty-six patients in the control group were compared to 33 patients in the experimental group. Anxiety before the operation increased significantly in the control group but remained at baseline level in the experimental group. Postoperative consumption of analgesics was significantly reduced in the experimental group compared to the control group. FAU - Enqvist, B AU - Enqvist B AD - Eastman Dental Centre, Stockholm, Sweden. FAU - Fischer, K AU - Fischer K LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Int J Clin Exp Hypn JT - The International journal of clinical and experimental hypnosis JID - 0376166 RN - 0 (Analgesics) RN - 0 (Drug Combinations) RN - 0 (acetaminophen, codeine drug combination) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/*administration & dosage MH - Adult MH - Analgesics/*administration & dosage MH - Codeine/*administration & dosage MH - Drug Combinations MH - Female MH - Humans MH - *Hypnosis, Dental MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Suggestion MH - *Tooth Extraction/psychology EDAT- 1997/04/01 00:00 MHDA- 1997/04/01 00:01 CRDT- 1997/04/01 00:00 PHST- 1997/04/01 00:00 [pubmed] PHST- 1997/04/01 00:01 [medline] PHST- 1997/04/01 00:00 [entrez] AID - 10.1080/00207149708416112 [doi] PST - ppublish SO - Int J Clin Exp Hypn. 1997 Apr;45(2):102-8. doi: 10.1080/00207149708416112. PMID- 7557767 OWN - NLM STAT- MEDLINE DCOM- 19951109 LR - 20091111 IS - 0071-7916 (Print) IS - 0071-7916 (Linking) VI - 40 DP - 1995 TI - [Results of a comparative prospective randomized study of surgical removal of mandibular wisdom teeth with and without rubber drainage]. PG - 134-6 AB - This investigation compared the results of 2 types of wound closure - primary closure technique with and without Penrose drains (Naturallatex) - after mandibular third Molar removal. In both the test group (n = 27) and control group (n = 25), the molar were removed using a buccal mucoperiosteal flap. The test group received a drain partially submerged into the socket to secure more drainage of woundsecrete. Examination were performed 1 day, 3 days and 7 days after surgery, and swelling, trismus, pain and analgetic consommation were recorded. Analysis of Variance indicated that there was significant difference between the 2 methods. The drain method appears to minimize postoperative edema, trismus, pain and analgetic consommation, and thus contributes to enhanced patient comfort. FAU - Ayad, W AU - Ayad W AD - Klinik für Mund-, Kiefer- und Gesichtschirugie-Plastische Operationen-Knappschaftskrankenhaus Akademisches Lehrkrankenhaus, Universität Bochum, Recklinghausen. FAU - Jöhren, P AU - Jöhren P FAU - Dieckmann, J AU - Dieckmann J LA - ger PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Ergebnisse einer prospektiv randomisierten Studie zur operativen Entfernung unterer Weisheitszähne mit und ohne Gummi-Drainage im Vergleich. PL - Germany TA - Fortschr Kiefer Gesichtschir JT - Fortschritte der Kiefer- und Gesichts-Chirurgie JID - 0066413 SB - D SB - IM MH - Drainage/*instrumentation MH - Humans MH - Mandible/surgery MH - Molar, Third/*surgery MH - Postoperative Complications/etiology MH - Prospective Studies MH - Tooth Extraction/*instrumentation MH - Tooth, Impacted/*surgery EDAT- 1995/01/01 00:00 MHDA- 1995/01/01 00:01 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 1995/01/01 00:01 [medline] PHST- 1995/01/01 00:00 [entrez] PST - ppublish SO - Fortschr Kiefer Gesichtschir. 1995;40:134-6. PMID- 2245092 OWN - NLM STAT- MEDLINE DCOM- 19910108 LR - 20201209 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 169 IP - 8 DP - 1990 Oct 20 TI - A comparison of ibuprofen and ibuprofen-codeine combination in the relief of post-operative oral surgery pain. PG - 245-7 AB - Non-steroidal anti-inflammatory analgesics are commonly prescribed to out-patients who have undergone oral surgical procedures, since they are said to provide excellent pain relief for mild to moderate pain, allied with minimal side-effects. One hundred patients were entered into a randomised clinical trial to compare the efficacy of a simple non-steroidal analgesic with that of a combination analgesic compound following the removal of lower third molars under local anaesthesia. Pain scores were measured for patients post-operatively by means of a verbal rating scale for 3 days and data were analysed using the Mann-Whitney U-test. Results suggest that this combination product offers no advantages (but shows definite disadvantages) when compared to an effective non-steroidal anti-inflammatory product. FAU - Walton, G M AU - Walton GM AD - Department of Oral and Maxillofacial Surgery, Turner Dental School, Manchester. FAU - Rood, J P AU - Rood JP LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Drug Combinations) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM CIN - Br Dent J. 1990 Dec 8-22;169(11):350. PMID: 2275831 MH - Adolescent MH - Adult MH - Aged MH - Codeine/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Drug Interactions MH - Humans MH - Ibuprofen/*therapeutic use MH - Middle Aged MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1990/10/20 00:00 MHDA- 1990/10/20 00:01 CRDT- 1990/10/20 00:00 PHST- 1990/10/20 00:00 [pubmed] PHST- 1990/10/20 00:01 [medline] PHST- 1990/10/20 00:00 [entrez] AID - 10.1038/sj.bdj.4807341 [doi] PST - ppublish SO - Br Dent J. 1990 Oct 20;169(8):245-7. doi: 10.1038/sj.bdj.4807341. PMID- 1453032 OWN - NLM STAT- MEDLINE DCOM- 19921231 LR - 20190918 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 21 IP - 5 DP - 1992 Oct TI - Does metronidazole prevent alveolitis sicca dolorosa? A double-blind, placebo-controlled clinical study. PG - 299-302 AB - The effect of a single preoperative dose of metronidazole in the prevention of alveolitis sicca dolorosa (ASD) after surgical removal of one impacted, non-infected mandibular third molar was investigated. A patient sample of 270 were given either 1000 mg of metronidazole or placebo at least 30 min before surgery. The preoperative recordings included gender, age, tooth to be removed, experience of surgeon, time of test medication, and duration of surgery. No difference was found between the metronidazole and placebo groups in the occurrence of ASD. The duration of surgery and the experience of the operating surgeons had no effect on the occurrence of ASD. The present study failed to demonstrate any preventive effect of a single dose of metronidazole on the development of ASD. FAU - Ritzau, M AU - Ritzau M AD - Department of Oral and Maxillofacial Surgery, Royal Dental College, Arhus, Denmark. FAU - Hillerup, S AU - Hillerup S FAU - Branebjerg, P E AU - Branebjerg PE FAU - Ersbøl, B K AU - Ersbøl BK LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Placebos) RN - 140QMO216E (Metronidazole) SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Metronidazole/administration & dosage/*therapeutic use MH - Molar, Third/surgery MH - Placebos MH - *Premedication MH - Probability MH - Prospective Studies MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery EDAT- 1992/10/01 00:00 MHDA- 1992/10/01 00:01 CRDT- 1992/10/01 00:00 PHST- 1992/10/01 00:00 [pubmed] PHST- 1992/10/01 00:01 [medline] PHST- 1992/10/01 00:00 [entrez] AID - 10.1016/s0901-5027(05)80743-x [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1992 Oct;21(5):299-302. doi: 10.1016/s0901-5027(05)80743-x. PMID- 7624100 OWN - NLM STAT- MEDLINE DCOM- 19950828 LR - 20131121 IS - 0028-7571 (Print) IS - 0028-7571 (Linking) VI - 61 IP - 6 DP - 1995 Jun-Jul TI - Prevention of dry socket with clindamycin. A retrospective study. PG - 30-3 AB - Clindamycin and other agents were compared for efficacy in preventing the entity "dry socket." A total 765 patients were treated with clindamycin, per os, and 408 patients were treated with other antibiotics or were non-treated controls. All patients underwent surgical removal of impacted mandibular third molars. The incidence of dry socket in untreated control and in non-clindamycin antibiotic-treated patients varied from 15 to 31 percent, while in those patients receiving clindamycin, the incidence was 0.65 percent. The results demonstrate a remarkable effectiveness of clindamycin in reducing the incidence of dry socket following surgical removal of impacted mandibular third molar. FAU - Kupfer, S R AU - Kupfer SR AD - Brooklyn VA Medical Center, USA. LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - N Y State Dent J JT - The New York state dental journal JID - 0414634 RN - 0 (Penicillins) RN - 3U02EL437C (Clindamycin) RN - 525-97-3 (penicillin K) RN - BOD072YW0F (Lincomycin) RN - X8XI70B5Z6 (Nitrofurazone) SB - D SB - IM MH - Adult MH - Aged MH - Bacteroides Infections/*prevention & control MH - Clindamycin/pharmacology/*therapeutic use MH - Dry Socket/microbiology/*prevention & control MH - Female MH - Humans MH - Lincomycin/therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Nitrofurazone/therapeutic use MH - Penicillins/therapeutic use MH - Prevotella melaninogenica/drug effects MH - Retrospective Studies MH - *Tooth Extraction EDAT- 1995/06/01 00:00 MHDA- 1995/06/01 00:01 CRDT- 1995/06/01 00:00 PHST- 1995/06/01 00:00 [pubmed] PHST- 1995/06/01 00:01 [medline] PHST- 1995/06/01 00:00 [entrez] PST - ppublish SO - N Y State Dent J. 1995 Jun-Jul;61(6):30-3. PMID- 11726064 OWN - NLM STAT- MEDLINE DCOM- 20020122 LR - 20190719 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 191 IP - 9 DP - 2001 Nov 10 TI - Salivary cortisol determinations and self-rating scales in the assessment of stress in patients undergoing the extraction of wisdom teeth. PG - 513-5 AB - OBJECTIVE: To investigate salivary cortisol levels in patients undergoing third molar removal under local and general anaesthesia. DESIGN: Random sampling of two independent groups. METHODS: Samples of saliva were collected from patients prior to and after surgery for the removal of impacted wisdom teeth. The samples were analysed to assess cortisol levels. Patients were also asked to complete a Hospital Anxiety and Depression questionnaire on the day of surgery. RESULTS: Patients receiving treatment under local anaesthesia showed lower levels of stress response than those having treatment under general anaesthesia on the actual day of surgery did (Fig. 1). No other significant differences were noted. CONCLUSION: Local anaesthesia is the preferred mode of pain control for patients who express no strong preference for type of anaesthetic. FAU - Hill, C M AU - Hill CM AD - University of Wales College of Medicine, Dental School, Cardiff. FAU - Walker, R V AU - Walker RV LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - WI4X0X7BPJ (Hydrocortisone) SB - D SB - IM MH - Adult MH - Anesthesia, Dental MH - Anesthesia, General MH - Anesthesia, Local MH - Anxiety/classification MH - Attitude to Health MH - Depression/classification MH - Follow-Up Studies MH - Humans MH - Hydrocortisone/*analysis MH - Molar, Third/*surgery MH - Saliva/*chemistry MH - *Self-Assessment MH - Statistics as Topic MH - Stress, Physiological/*classification/metabolism MH - Stress, Psychological/*classification/metabolism MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2001/12/01 10:00 MHDA- 2002/01/23 10:01 CRDT- 2001/12/01 10:00 PHST- 2001/12/01 10:00 [pubmed] PHST- 2002/01/23 10:01 [medline] PHST- 2001/12/01 10:00 [entrez] AID - 10.1038/sj.bdj.4801220 [doi] PST - ppublish SO - Br Dent J. 2001 Nov 10;191(9):513-5. doi: 10.1038/sj.bdj.4801220. PMID- 9486442 OWN - NLM STAT- MEDLINE DCOM- 19980320 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 35 IP - 6 DP - 1997 Dec TI - Routine review of patients after extraction of third molars: is it justified? PG - 393-5 AB - A prospective study of 80 patients undergoing the surgical removal of impacted mandibular third molar teeth under general anaesthesia was carried out. Patients were randomly allocated to either of two groups, one of which (n = 42) was reviewed 1-2 weeks postoperatively, and one of which was not (n = 38). Those who were not reviewed were discharged with a letter containing telephone numbers to contact in case of problems. Patients' satisfaction was gauged by means of a questionnaire completed either at the review appointment or by postal survey. Three-quarters of patients who were reviewed (34/42) and three-quarters of those who were not (9/12) preferred the method of follow-up that they experienced, whether reviewed or not. A policy of selective review may be appropriate whereby only patients whose operations were problematic or who had operative or postoperative complications are reviewed. Patients who are not reviewed should be given clear instructions to contact the department if they are concerned about their postoperative condition. FAU - Preshaw, P M AU - Preshaw PM AD - Department of Restorative Dentistry, The Dental School, Newcastle upon Tyne, UK. FAU - Fisher, S E AU - Fisher SE LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Adolescent MH - Adult MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Postoperative Care/*statistics & numerical data MH - Prospective Studies MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1998/03/05 00:00 MHDA- 1998/03/05 00:01 CRDT- 1998/03/05 00:00 PHST- 1998/03/05 00:00 [pubmed] PHST- 1998/03/05 00:01 [medline] PHST- 1998/03/05 00:00 [entrez] AID - 10.1016/s0266-4356(97)90713-0 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1997 Dec;35(6):393-5. doi: 10.1016/s0266-4356(97)90713-0. PMID- 289417 OWN - NLM STAT- MEDLINE DCOM- 19791121 LR - 20191028 IS - 0007-117X (Print) IS - 0007-117X (Linking) VI - 17 IP - 1 DP - 1979 Jul TI - Metronidazole in the prevention of 'dry socket'. PG - 62-70 AB - Prophylactic metronidazole was found to be an effective means of preventing 'dry socket' after routine dental extractions. The oral anaerobic bacterial may be implicated therefore in the development of the disorder. It has been confirmed in this study that 'dry socket' occurs following three per cent of routine dental extractions and almost exclusively in the mandible. The causes of the condition are probably numerous and may even vary from patient to patient, but the control of infection by anerobic organisms may be important in its prevention or early resolution. The prophylactic administration of metronidazole (Flagyl) has been shown to be a simple and effective method of prevention which would suggest the implication of anaerobic organisms in 'dry socket'. The drug appears to be free from side effects when a dosage of 200 mgs eight hourly for three days is given. FAU - Rood, J P AU - Rood JP FAU - Murgatroyd, J AU - Murgatroyd J LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Scotland TA - Br J Oral Surg JT - The British journal of oral surgery JID - 0400651 RN - 0 (Placebos) RN - 140QMO216E (Metronidazole) SB - D SB - IM MH - Adult MH - Age Factors MH - Aged MH - Bacteria/cytology MH - Blood Coagulation MH - Double-Blind Method MH - Drug Evaluation MH - Dry Socket/microbiology/physiopathology/*prevention & control MH - Evaluation Studies as Topic MH - Female MH - Humans MH - Male MH - Metronidazole/*therapeutic use MH - Middle Aged MH - Placebos MH - Tooth Extraction EDAT- 1979/07/01 00:00 MHDA- 1979/07/01 00:01 CRDT- 1979/07/01 00:00 PHST- 1979/07/01 00:00 [pubmed] PHST- 1979/07/01 00:01 [medline] PHST- 1979/07/01 00:00 [entrez] AID - 10.1016/0007-117x(79)90009-x [doi] PST - ppublish SO - Br J Oral Surg. 1979 Jul;17(1):62-70. doi: 10.1016/0007-117x(79)90009-x. PMID- 7568694 OWN - NLM STAT- MEDLINE DCOM- 19951026 LR - 20060711 IS - 0033-6572 (Print) IS - 0033-6572 (Linking) VI - 25 IP - 12 DP - 1994 Dec TI - Effect of incision and flap reflection on postoperative pain after the removal of partially impacted mandibular third molars. PG - 845-9 AB - A clinical trial was carried out to evaluate the influence of incision and reflection of a flap on pain after the removal of partially erupted mandibular third molars. A sequential design for intraindividual comparisons was chosen. The patients underwent bilateral extraction of partially impacted mandibular third molars with a standard incision on one side (control) and without incision (test) on the other side. One week postoperatively, the patients were asked on which side they had experienced more postoperative pain. The preset level of significance (P < .05) was reached after 11 patients were treated. Eight patients had more severe pain on the control side, while three patients did not experience any difference in pain between the two sides. The nonsurgical approach did not increase the chair time and appeared to be an effective way of reducing postoperative discomfort after extraction of partially erupted third molars. FAU - Clauser, C AU - Clauser C FAU - Barone, R AU - Barone R LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 SB - D MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - *Pain, Postoperative/etiology/prevention & control MH - Surgical Flaps/adverse effects/methods MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/*surgery EDAT- 1994/12/01 00:00 MHDA- 1994/12/01 00:01 CRDT- 1994/12/01 00:00 PHST- 1994/12/01 00:00 [pubmed] PHST- 1994/12/01 00:01 [medline] PHST- 1994/12/01 00:00 [entrez] PST - ppublish SO - Quintessence Int. 1994 Dec;25(12):845-9. PMID- 8156566 OWN - NLM STAT- MEDLINE DCOM- 19940513 LR - 20180216 IS - 0008-6568 (Print) IS - 0008-6568 (Linking) VI - 28 IP - 2 DP - 1994 TI - Fluoride profile in mature unerupted enamel following removal of surface organic material. PG - 83-6 AB - The aim of the present study was to determine fluoride profiles in mature unerupted enamel following removal of the surface organic material. Thirty teeth were randomly allocated into three groups. The surface organic material (Nasmyth's membrane) was left intact in group I; it was removed by tooth-brushing in group II, and in group III the surface organic layer was removed along with subsurface organic material by deproteinizing. Each tooth was then sectioned into halves and a standardized biopsy area was created. Initially alkali-soluble fluoride was extracted with 1M KOH followed by acid etch analysis to measure the remaining fluoride. No difference was seen in the alkali-soluble fluoride levels but residual fluoride concentrations were significantly reduced (p < 0.05) after deproteinizing but not after toothbrushing. It would appear that a substantial amount of fluoride (approximately 25%) in mature enamel from unerupted teeth can be removed by a deproteinizing agent, which may suggest an association of this fluoride with subsurface organic material. FAU - Nainar, S M AU - Nainar SM AD - Department of Pediatric Dentistry, School of Dental Medicine, University of Connecticut Health Center, Farmington. FAU - Clarkson, B H AU - Clarkson BH LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Switzerland TA - Caries Res JT - Caries research JID - 0103374 RN - 0 (Dental Enamel Proteins) RN - 0 (Hydroxides) RN - 0 (Potassium Compounds) RN - 8W8T17847W (Urea) RN - Q80VPU408O (Fluorides) RN - WZH3C48M4T (potassium hydroxide) SB - D SB - IM MH - Acid Etching, Dental MH - Amelogenesis MH - Dental Enamel/*chemistry MH - Dental Enamel Proteins/chemistry MH - Fluorides/*analysis MH - Humans MH - Hydroxides MH - Molar, Third/chemistry MH - Potassium Compounds MH - Time Factors MH - Tooth, Unerupted/*chemistry MH - Toothbrushing MH - Urea EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] AID - 10.1159/000261626 [doi] PST - ppublish SO - Caries Res. 1994;28(2):83-6. doi: 10.1159/000261626. PMID- 1761875 OWN - NLM STAT- MEDLINE DCOM- 19920207 LR - 20190918 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 20 IP - 5 DP - 1991 Oct TI - Efficacy of oral midazolam prior to intravenous sedation for the removal of third molars. PG - 264-7 AB - The combination of oral and intravenous sedation has not been well investigated and this study examined the combination's effect on amnesia, anxiety, cardiovascular stability and recovery in a double blind, cross-over, placebo controlled trial. Patients were given 7.5 mg oral midazolam or placebo 1 h prior to intravenous midazolam and surgery. This investigation demonstrated significant anxiolysis, amnesia and patient preference for oral midazolam compared to placebo. There was no significant effect on cardiovascular stability, the intravenous dose of midazolam used or post-operative recovery. Low dose oral midazolam prior to intravenous sedation may be beneficial in very anxious patients, particularly if surgery is delayed. FAU - Luyk, N H AU - Luyk NH AD - Dept. of Oral Medicine and Oral Surgery, School of Dentistry, Dunedin, New Zealand. FAU - Whitley, B D AU - Whitley BD LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Placebos) RN - 0 (Tablets) RN - R60L0SM5BC (Midazolam) SB - D SB - IM CIN - Int J Oral Maxillofac Surg. 1992 Apr;21(2):122. PMID: 1602160 MH - Administration, Oral MH - Adolescent MH - Adult MH - Analysis of Variance MH - *Anesthesia, Intravenous MH - Anxiety/prevention & control MH - Blood Pressure/drug effects MH - *Conscious Sedation MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Memory/drug effects MH - Midazolam/*administration & dosage MH - Molar, Third/*surgery MH - Placebos MH - *Preanesthetic Medication MH - Psychomotor Performance/drug effects MH - Pulse/drug effects MH - Tablets MH - *Tooth Extraction EDAT- 1991/10/01 00:00 MHDA- 1991/10/01 00:01 CRDT- 1991/10/01 00:00 PHST- 1991/10/01 00:00 [pubmed] PHST- 1991/10/01 00:01 [medline] PHST- 1991/10/01 00:00 [entrez] AID - 10.1016/s0901-5027(05)80149-3 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1991 Oct;20(5):264-7. doi: 10.1016/s0901-5027(05)80149-3. PMID- 3112261 OWN - NLM STAT- MEDLINE DCOM- 19870902 LR - 20201209 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 16 IP - 3 DP - 1987 Jun TI - Postoperative pain control for outpatient oral surgery. PG - 319-24 AB - 16 healthy patients requiring removal of bilateral symmetrically-impacted mandibular third molars participated in a double-blind randomised crossover trial to test the effectiveness of postoperative pain control using a long-acting anti-inflammatory agent (diflunisal) in combination with a long-acting local anaesthetic agent (bupivacaine). Results were compared to the more traditional method of using an oral analgesic with shorter duration of action (paracetamol with codeine) with lignocaine as the local anaesthetic. Using a visual analogue pain scale, patients reported that significantly reduced pain was experienced over the first 4 days postoperatively with the diflunisal/bupivacaine treatment and patient preference for this treatment was highly significant. This report represents the first such study of diflunisal used for an extended course in oral surgery with pain assessment over the same period. No significant side-effects or adverse reactions were encountered. FAU - Chapman, P J AU - Chapman PJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Salicylates) RN - 362O9ITL9D (Acetaminophen) RN - 7C546U4DEN (Diflunisal) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Acetaminophen/administration & dosage MH - Administration, Oral MH - Adolescent MH - Adult MH - Clinical Trials as Topic MH - Codeine/administration & dosage MH - Diflunisal/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Random Allocation MH - Salicylates/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 1987/06/01 00:00 MHDA- 1987/06/01 00:01 CRDT- 1987/06/01 00:00 PHST- 1987/06/01 00:00 [pubmed] PHST- 1987/06/01 00:01 [medline] PHST- 1987/06/01 00:00 [entrez] AID - 10.1016/s0901-5027(87)80153-4 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1987 Jun;16(3):319-24. doi: 10.1016/s0901-5027(87)80153-4. PMID- 22976514 OWN - NLM STAT- MEDLINE DCOM- 20121231 LR - 20151119 IS - 0026-4970 (Print) IS - 0026-4970 (Linking) VI - 61 IP - 7-8 DP - 2012 Jul-Aug TI - The effect of low level laser therapy on pain reduction after third molar surgery. PG - 319-22 AB - AIM: The aim of this study was to evaluate the effects of low level laser on the postoperative pain of patients who had to undergo third molar surgery. METHODS: In a randomized clinical setting, 100 patients were assigned to two groups of 50 in each. Every patient underwent surgical removal of one mandibular third molar (with osteotomy). After suturing the flap, the soft laser was applied to every patient. In group I laser radiation was applied by the dental assistant with output power of 100 mW, in continuous mode with sweeping motion, in group II, the laser hand piece was only brought into position without releasing energy, so that no patient knew which group he belonged to. The patient was given a pain evaluation form where they could determine their individual pain level and duration. RESULTS: The statistical tests showed significant difference in pain level between laser and control group (P<0.001) but no significant difference found in pain duration in two groups (P=0.019). CONCLUSION: The result of this study verifies the positive effect of the soft-laser therapy in the postoperative complication after third molar extraction. FAU - Saber, K AU - Saber K AD - Laser Research Center of Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. FAU - Chiniforush, N AU - Chiniforush N FAU - Shahabi, S AU - Shahabi S LA - eng LA - ita PT - Journal Article PT - Randomized Controlled Trial PL - Italy TA - Minerva Stomatol JT - Minerva stomatologica JID - 0421071 SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Double-Blind Method MH - Female MH - Humans MH - *Low-Level Light Therapy MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control/*radiotherapy MH - Tooth Extraction/*methods MH - Young Adult EDAT- 2012/09/15 06:00 MHDA- 2013/01/01 06:00 CRDT- 2012/09/15 06:00 PHST- 2012/09/15 06:00 [entrez] PHST- 2012/09/15 06:00 [pubmed] PHST- 2013/01/01 06:00 [medline] AID - R18123518 [pii] PST - ppublish SO - Minerva Stomatol. 2012 Jul-Aug;61(7-8):319-22. PMID- 8492199 OWN - NLM STAT- MEDLINE DCOM- 19930617 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 51 IP - 6 DP - 1993 Jun TI - A comparison of diclofenac with and without single-dose intravenous steroid to prevent postoperative pain after third molar removal. PG - 634-6 AB - The efficacy of 40 mg of methylprednisolone given intravenously before operation in combination with orally administered rapid-release and sustained-release diclofenac preparations in preventing postoperative pain after third molar removal was studied. The administration of methylprednisolone and diclofenac resulted in greater pain relief than did administration of diclofenac alone. FAU - Hyrkäs, T AU - Hyrkäs T AD - University of Helsinki, Finland. FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P FAU - Oikarinen, V J AU - Oikarinen VJ FAU - Paakkari, I AU - Paakkari I LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Delayed-Action Preparations) RN - 144O8QL0L1 (Diclofenac) RN - X4W7ZR7023 (Methylprednisolone) SB - AIM SB - D SB - IM MH - Administration, Oral MH - Adult MH - Delayed-Action Preparations MH - Diclofenac/*administration & dosage/therapeutic use MH - Drug Therapy, Combination MH - Female MH - Humans MH - Infusions, Intravenous MH - Male MH - Methylprednisolone/*administration & dosage/therapeutic use MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Premedication MH - *Tooth Extraction EDAT- 1993/06/01 00:00 MHDA- 1993/06/01 00:01 CRDT- 1993/06/01 00:00 PHST- 1993/06/01 00:00 [pubmed] PHST- 1993/06/01 00:01 [medline] PHST- 1993/06/01 00:00 [entrez] AID - S0278239193000904 [pii] AID - 10.1016/s0278-2391(10)80261-7 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1993 Jun;51(6):634-6. doi: 10.1016/s0278-2391(10)80261-7. PMID- 8471571 OWN - NLM STAT- MEDLINE DCOM- 19930520 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 31 IP - 2 DP - 1993 Apr TI - Recovery from intravenous sedation with midazolam--the value of flumazenil. PG - 101-3 AB - A total of 40 patients receiving intravenous midazolam for surgical removal of impacted wisdom teeth were randomly assigned to recover either spontaneously or undergo reversal by the benzodiazepine antagonist flumazenil. Whilst initial postoperative recovery to a 'fully awake' state occurred more rapidly in the reversal group, objective psychomotor testing revealed significantly poorer performance postoperatively compared with spontaneously recovering patients; this emphasises the need to retain patients for at least 1 h prior to discharge home. FAU - Thomson, P J AU - Thomson PJ AD - Department of Oral and Maxillofacial Medicine and Surgery, Turner Dental School, University of Manchester. FAU - Coulthard, P AU - Coulthard P FAU - Snowdon, A T AU - Snowdon AT FAU - Mitchell, K AU - Mitchell K LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 40P7XK9392 (Flumazenil) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Adult MH - *Anesthesia Recovery Period MH - Anesthesia, Dental/methods MH - Chi-Square Distribution MH - Conscious Sedation/methods MH - Consciousness/drug effects MH - Flumazenil/*pharmacology/therapeutic use MH - Humans MH - Midazolam/*antagonists & inhibitors MH - Molar, Third/*surgery MH - Postoperative Care/methods MH - Psychomotor Performance/*drug effects MH - Single-Blind Method MH - Time Factors MH - Tooth Extraction EDAT- 1993/04/01 00:00 MHDA- 1993/04/01 00:01 CRDT- 1993/04/01 00:00 PHST- 1993/04/01 00:00 [pubmed] PHST- 1993/04/01 00:01 [medline] PHST- 1993/04/01 00:00 [entrez] AID - 0266-4356(93)90170-2 [pii] AID - 10.1016/0266-4356(93)90170-2 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1993 Apr;31(2):101-3. doi: 10.1016/0266-4356(93)90170-2. PMID- 9549914 OWN - NLM STAT- MEDLINE DCOM- 19980423 LR - 20181201 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 184 IP - 4 DP - 1998 Feb 28 TI - An accurate method for the measurement of blood loss during dental procedures. PG - 177 FAU - Rodd, H AU - Rodd H AD - School of Clinical Dentistry, University of Sheffield. LA - eng PT - Clinical Trial PT - Comment PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Alginates) RN - 0 (Hemostatics) RN - 0 (Hexuronic Acids) RN - 8A5D83Q4RW (Glucuronic Acid) SB - D SB - IM CON - Br Dent J. 1998 Feb 28;184(4):187-90. PMID: 9549917 MH - Alginates/*therapeutic use MH - Anemia, Iron-Deficiency MH - Anesthesia, Dental/methods MH - Anesthesia, General/statistics & numerical data MH - Blood Loss, Surgical/*prevention & control MH - Blood Volume MH - Child, Preschool MH - *Dental Care for Children MH - Dental Care for Chronically Ill MH - Glucuronic Acid MH - Gossypium/therapeutic use MH - Hemostasis, Surgical/*instrumentation/methods MH - Hemostatics/*therapeutic use MH - Hexuronic Acids MH - Humans MH - Oral Hemorrhage/etiology/*prevention & control MH - Phytotherapy MH - Prospective Studies MH - Reproducibility of Results MH - Surgical Sponges MH - Tooth Extraction/*adverse effects EDAT- 1998/04/29 00:00 MHDA- 1998/04/29 00:01 CRDT- 1998/04/29 00:00 PHST- 1998/04/29 00:00 [pubmed] PHST- 1998/04/29 00:01 [medline] PHST- 1998/04/29 00:00 [entrez] AID - 4809573 [pii] AID - 10.1038/sj.bdj.4809573 [doi] PST - ppublish SO - Br Dent J. 1998 Feb 28;184(4):177. doi: 10.1038/sj.bdj.4809573. PMID- 3145948 OWN - NLM STAT- MEDLINE DCOM- 19890302 LR - 20190919 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 17 IP - 6 DP - 1988 Dec TI - The effectiveness of flurazepam as night sedation prior to the removal of third molars. PG - 347-51 AB - Anxiety prior to dental treatment is a well-recognized problem. Although oral sedation has been recommended the night before appointments to reduce this anxiety, there are no well-controlled studies to support this claim. The present double-blind cross-over study investigated the effect of 30 mg of flurazepam taken the night before the removal of impacted third molars. Preoperative anxiety, visuomotor performance and sleep patterns were investigated in 20 adult patients with similarly impacted third molars. While preoperative flurazepam led to a statistically significant improvement in sleep patterns, there was no reduction in pre-operative anxiety on the morning of surgery. In addition, the flurazepam-treated group demonstrated significantly impaired visuo-motor performance 60 min after intravenous sedation compared to this group where intravenous sedation was used only preceded by placebo. Patients had a significant preference for flurazepam over placebo as a night-time sedative. FAU - Luyk, N H AU - Luyk NH AD - Section of Oral and Maxillofacial Surgery, College of Dentistry, Ohio State University, Columbus 43210. FAU - Weaver, J M AU - Weaver JM FAU - Beck, F M AU - Beck FM FAU - Loetscher, C A AU - Loetscher CA FAU - Sacks, J AU - Sacks J LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - IHP475989U (Flurazepam) SB - D SB - IM MH - Adult MH - Anxiety/*drug therapy MH - Double-Blind Method MH - Female MH - Flurazepam/administration & dosage/*therapeutic use MH - Humans MH - Male MH - Molar, Third/*surgery MH - *Premedication MH - Sleep/*drug effects MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1988/12/01 00:00 MHDA- 1988/12/01 00:01 CRDT- 1988/12/01 00:00 PHST- 1988/12/01 00:00 [pubmed] PHST- 1988/12/01 00:01 [medline] PHST- 1988/12/01 00:00 [entrez] AID - 10.1016/s0901-5027(88)80060-2 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1988 Dec;17(6):347-51. doi: 10.1016/s0901-5027(88)80060-2. PMID- 2304739 OWN - NLM STAT- MEDLINE DCOM- 19900320 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 69 IP - 2 DP - 1990 Feb TI - Analgesic and antiinflammatory effects of glucamethacin (a nonsteroidal antiinflammatory analgesic) after the removal of impacted third molars. PG - 157-60 AB - A double-blind study was undertaken to compare the effects of glucamethacin, aspirin, and placebo in the control of pain, trismus, and postoperative swelling of 59 outpatients who underwent the surgical removal of impacted lower third molars. Aspirin (1000 mg three times a day) was superior to placebo in one of the analgesic parameters studied, whereas glucamethacin (140 mg three times a day) was not superior to placebo. Both drugs significantly reduced the occurrence of trismus on the day after surgery, but no differences with placebo were found 48 hours postoperatively. In the study of postoperative swelling, no significant differences were found between the medications and the placebo in the postoperative period. It is concluded that glucamethacin, a nonsteroidal antiinflammatory drug, produces a minimal analgesic effect and does not relieve postoperative swelling in the dental patient undergoing surgical removal of impacted third molars. FAU - Gallardo, F AU - Gallardo F AD - School of Medicine, Department of Pharmacology, University of Chile, Santiago. FAU - Carstens, M AU - Carstens M FAU - Ayarza, M AU - Ayarza M LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - N1EXE5EHAN (glucametacin) RN - R16CO5Y76E (Aspirin) RN - XXE1CET956 (Indomethacin) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Aspirin/therapeutic use MH - Chi-Square Distribution MH - Double-Blind Method MH - Edema/drug therapy MH - Female MH - Humans MH - Indomethacin/*analogs & derivatives/therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth, Impacted/*surgery MH - Trismus/drug therapy EDAT- 1990/02/01 00:00 MHDA- 1990/02/01 00:01 CRDT- 1990/02/01 00:00 PHST- 1990/02/01 00:00 [pubmed] PHST- 1990/02/01 00:01 [medline] PHST- 1990/02/01 00:00 [entrez] AID - 10.1016/0030-4220(90)90317-l [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1990 Feb;69(2):157-60. doi: 10.1016/0030-4220(90)90317-l. PMID- 11696916 OWN - NLM STAT- MEDLINE DCOM- 20020103 LR - 20151119 IS - 0103-6440 (Print) IS - 0103-6440 (Linking) VI - 12 IP - 3 DP - 2001 TI - Assessment of anti-inflammatory effect of 830nm laser light using C-reactive protein levels. PG - 187-90 AB - The anti-inflammatory effect of non-surgical lasers has been proposed previously, however it was not scientifically proven. One method to assess levels of inflammation is the measurement of C-reactive protein (CRP), which is increased with the course of inflammation. The aim of this study was to assess the effect of 830 nm laser irradiation after the removal of impacted third molars using the CRP as the marker of inflammation. Twelve patients were irradiated with 4.8 J of laser light per session 24 and 48 h after surgery. A control group (N = 12) was treated with a sham laser. Blood samples were taken prior to, and 48 and 72 h after surgery. CRP values were more symmetric and better distributed for the irradiated group (0.320 mg/dl) than for the control (0.862.mg/dl) 48 h after surgery, however there was no statistically significant difference. After 72 h, both groups had statistically similar CRP levels (0.272 and 0.608 mg/dl), because of the normal tendency of decreasing CRP levels. FAU - Freitas, A C AU - Freitas AC AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, PUC-RS, Porto Alegre, RS, Brazil. FAU - Pinheiro, A L AU - Pinheiro AL FAU - Miranda, P AU - Miranda P FAU - Thiers, F A AU - Thiers FA FAU - Vieira, A L AU - Vieira AL LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Brazil TA - Braz Dent J JT - Brazilian dental journal JID - 9214652 RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - D MH - Adolescent MH - Adult MH - Biomarkers/blood MH - C-Reactive Protein/*analysis MH - Humans MH - Inflammation/blood/*prevention & control MH - *Low-Level Light Therapy MH - Molar, Third/surgery MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects EDAT- 2001/11/08 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/11/08 10:00 PHST- 2001/11/08 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/11/08 10:00 [entrez] PST - ppublish SO - Braz Dent J. 2001;12(3):187-90. PMID- 8409569 OWN - NLM STAT- MEDLINE DCOM- 19931112 LR - 20190920 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 22 IP - 4 DP - 1993 Aug TI - The effect of soft-laser application on postoperative pain and swelling. A double-blind, crossover study. PG - 242-5 AB - The effect of soft-laser application on postoperative pain and swelling was evaluated in a double-blind, crossover study. Twenty-five healthy adults with bilateral identically impacted lower third molars were selected for this study. The teeth were removed in two separate operations. Laser treatment was tested in comparison with placebo laser, with a 40-mW, 830-nm Biophoton laser (Roenvig Dental, Denmark). All surgical procedures and measurements were done by the same surgeon. The following features were statistically analyzed: swelling, trismus, and subjective registration of pain on a visual analog scale. No statistically significant differences were observed in comparison of the experimental side with the placebo side. It may be concluded that soft-laser treatment has no beneficial effect on swelling, trismus, and pain after third molar surgery. FAU - Røynesdal, A K AU - Røynesdal AK AD - Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Norway. FAU - Björnland, T AU - Björnland T FAU - Barkvoll, P AU - Barkvoll P FAU - Haanaes, H R AU - Haanaes HR LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Adolescent MH - Adult MH - Double-Blind Method MH - Edema/radiotherapy MH - Female MH - Humans MH - *Laser Therapy MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*radiotherapy MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Trismus/radiotherapy EDAT- 1993/08/01 00:00 MHDA- 1993/08/01 00:01 CRDT- 1993/08/01 00:00 PHST- 1993/08/01 00:00 [pubmed] PHST- 1993/08/01 00:01 [medline] PHST- 1993/08/01 00:00 [entrez] AID - 10.1016/s0901-5027(05)80646-0 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1993 Aug;22(4):242-5. doi: 10.1016/s0901-5027(05)80646-0. PMID- 3112263 OWN - NLM STAT- MEDLINE DCOM- 19870902 LR - 20190919 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 16 IP - 3 DP - 1987 Jun TI - Oral midazolam sedation in third molar surgery. PG - 333-7 AB - A double-blind randomised study was designed to assess the value of oral midazolam in patients undergoing minor oral surgery. 30 young healthy Hong Kong Chinese with bilateral symmetrical impaction of lower third molars to be surgically removed in 2 visits, were included in the study. Randomly selected, a powdered midazolam tablet or placebo was given on the 1st visit and the alternative on the 2nd visit. 45 min were given for the drug to act. Surgical removal of the teeth was carried out by a single operator, randomly, one side being done at one visit. The majority who had midazolam were relaxed during the operation. Nearly 75% had partial to complete amnesia. Midazolam sedation lasted about 45 min, produced good operating conditions and stable vital signs with adequate verbal response. The main adverse effects were drowsiness and dizziness on the same day. The majority had never heard of oral sedation being available to supplement local anaesthesia. The majority preferred midazolam to placebo and preferred to have local anaesthesia supplemented with oral sedation for minor oral surgery in the future. FAU - Rodrigo, M R AU - Rodrigo MR FAU - Cheung, L K AU - Cheung LK LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - *Anesthesia, Dental MH - Dizziness/chemically induced MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Midazolam/*administration & dosage/adverse effects MH - Molar, Third/*surgery MH - *Preanesthetic Medication MH - Random Allocation MH - Sleep Stages MH - Tooth, Impacted/*surgery EDAT- 1987/06/01 00:00 MHDA- 1987/06/01 00:01 CRDT- 1987/06/01 00:00 PHST- 1987/06/01 00:00 [pubmed] PHST- 1987/06/01 00:01 [medline] PHST- 1987/06/01 00:00 [entrez] AID - 10.1016/s0901-5027(87)80155-8 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1987 Jun;16(3):333-7. doi: 10.1016/s0901-5027(87)80155-8. PMID- 6756936 OWN - NLM STAT- MEDLINE DCOM- 19830214 LR - 20201209 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 23 IP - 4 DP - 1982 Oct TI - Paracetamol plus supplementary doses of codeine. An analgesic study of repeated doses. PG - 315-9 AB - A double-blind, multicentre analgesic trial was carried out in patients suffering from pain after removal of an impacted lower wisdom tooth. 266 patients were evaluated after random allocation to treatment with paracetamol 500 mg, paracetamol 500 mg plus codeine 20 mg, paracetamol 500 mg plus codeine 30 mg, or paracetamol 500 mg plus codeine 40 mg. On the day of surgery the patients assessed their own pain intensity hourly on a visual analogue scale. The analysis of the results was carried out according to the method which considered repeated dose intake. A statiscally significant dose-response relationship was obtained between the supplementary doses of codeine and analgesic efficacy. In the comparison of side effects, their frequency increased with increasing amounts of codeine. In clinical practice codeine 30 mg appeared to be the optimal supplement for paracetamol 500 mg. FAU - Quiding, H AU - Quiding H FAU - Persson, G AU - Persson G FAU - Ahlström, U AU - Ahlström U FAU - Bångens, S AU - Bångens S FAU - Hellem, S AU - Hellem S FAU - Johansson, G AU - Johansson G FAU - Jönsson, E AU - Jönsson E FAU - Nordh, P G AU - Nordh PG LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/*administration & dosage/adverse effects/therapeutic use MH - Clinical Trials as Topic MH - Codeine/*administration & dosage/adverse effects/therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Combinations MH - Humans MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1982/10/01 00:00 MHDA- 1982/10/01 00:01 CRDT- 1982/10/01 00:00 PHST- 1982/10/01 00:00 [pubmed] PHST- 1982/10/01 00:01 [medline] PHST- 1982/10/01 00:00 [entrez] AID - 10.1007/BF00613612 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1982 Oct;23(4):315-9. doi: 10.1007/BF00613612. PMID- 2709216 OWN - NLM STAT- MEDLINE DCOM- 19890601 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 47 IP - 5 DP - 1989 May TI - Comparison of preoperative and postoperative diflunisal for suppression of postoperative pain. PG - 464-8 AB - Despite the demonstrated therapeutic advantage of preoperatively administered nonsteroidal anti-inflammatory agents (NSAIAs) in suppressing postoperative pain, clinicians are reluctant to administer these drugs orally before surgical procedures performed using sedation or general anesthesia. Using a within-subject, crossover experimental design, this study compared the analgesic efficacies of an NSAIA, diflunisal 1,000 mg, administered either 30 minutes preoperatively or 30 minutes postoperatively to 20 patients undergoing the removal of impacted third molars. Pain intensity was assessed preoperatively and postoperatively for eight hours using category-rating and visual analog scales. Treatment with diflunisal 30 minutes after completion of surgery proved to be just as effective in suppressing postsurgical pain as presurgical administration. Administration of an NSAID in the immediate postoperative period may be indicated for optimum postoperative analgesia for patients in whom preoperative oral intake is contraindicated. FAU - Sisk, A L AU - Sisk AL AD - Medical College of Georgia, School of Dentistry, Department of Oral and Maxillofacial Surgery, Augusta 30912. FAU - Mosley, R O AU - Mosley RO FAU - Martin, R P AU - Martin RP LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Salicylates) RN - 7C546U4DEN (Diflunisal) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Diflunisal/*administration & dosage MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/drug therapy/*prevention & control MH - Postoperative Period MH - *Preanesthetic Medication MH - Random Allocation MH - Salicylates/*administration & dosage MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1989/05/01 00:00 MHDA- 1989/05/01 00:01 CRDT- 1989/05/01 00:00 PHST- 1989/05/01 00:00 [pubmed] PHST- 1989/05/01 00:01 [medline] PHST- 1989/05/01 00:00 [entrez] AID - 0278-2391(89)90278-4 [pii] AID - 10.1016/0278-2391(89)90278-4 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1989 May;47(5):464-8. doi: 10.1016/0278-2391(89)90278-4. PMID- 10687910 OWN - NLM STAT- MEDLINE DCOM- 20000225 LR - 20131121 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 37 IP - 6 DP - 1999 Dec TI - Comparison of two techniques of patient-controlled sedation with midazolam. PG - 472-6 AB - OBJECTIVE: To compare patient-controlled sedation with 1-mg increments of midazolam at 1-min intervals with 0.1-mg increments of midazolam without a lock-out interval. DESIGN: Randomized cross over study. SUBJECTS: 32 patients aged 17-35 years having third molars removed. RESULTS: Doses of midazolam obtained, degree of sedation and operating conditions were similar in the two groups. The demands far exceeded the increments actually received by patients obtaining 0.1-mg increments. Some were extremely sedated with both techniques. CONCLUSIONS: In this age group, there were no significant advantages or disadvantages of one technique over the other. Patients obtained the degree of sedation they required to undergo the operation by pressing the button independently of the dose or incremental interval. So-called 'true' patient-controlled sedation is a misnomer. The cut-off interval proved to be an extremely important safety feature. FAU - Rodrigo, M R AU - Rodrigo MR AD - Faculty of Dentistry, University of Hong Kong, Hong Kong, PR China. FAU - Fung, S C AU - Fung SC LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Hypnotics and Sedatives) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Adolescent MH - Adult MH - *Analgesia, Patient-Controlled MH - Anesthesia, Dental/*methods MH - Conscious Sedation/methods MH - Cross-Over Studies MH - Female MH - Humans MH - Hypnotics and Sedatives/*administration & dosage MH - Male MH - Midazolam/*administration & dosage MH - Molar, Third/*surgery MH - Patient Satisfaction MH - Tooth Extraction EDAT- 2000/02/25 09:00 MHDA- 2000/03/04 09:00 CRDT- 2000/02/25 09:00 PHST- 2000/02/25 09:00 [pubmed] PHST- 2000/03/04 09:00 [medline] PHST- 2000/02/25 09:00 [entrez] AID - S0266-4356(99)90118-3 [pii] AID - 10.1054/bjom.1999.0118 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1999 Dec;37(6):472-6. doi: 10.1054/bjom.1999.0118. PMID- 3110315 OWN - NLM STAT- MEDLINE DCOM- 19870727 LR - 20190919 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 16 IP - 2 DP - 1987 Apr TI - Tinidazole or pivampicillin in third molar surgery. PG - 171-4 AB - There is an increasing body of evidence implicating oral anaerobic bacteria in the aetiology of post-surgical dentoalveolar infections. This information has lead to several studies demonstrating the usefulness of specific anaerobicidal drugs in the prevention and treatment of dento-alveolar infection. One such study utilised a single 2 g preoperative oral dose of tinidazole which was found to be significantly better than placebo in preventing infective sequelae after removal of impacted mandibular third molars. The present study was designed to compare a high-dose short-term broad spectrum penicillin, (pivampicillin), with the previously described regimen, using tinidazole in order to discern the existence or otherwise of any practical difference between an anaerobicidal and a broad spectrum antibiotic when local infection was considered. FAU - Mitchell, D A AU - Mitchell DA FAU - Morris, T A AU - Morris TA LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Nitroimidazoles) RN - 0 (Placebos) RN - 033KF7V46H (Tinidazole) RN - 0HLM346LL7 (Pivampicillin) RN - 7C782967RD (Ampicillin) SB - D SB - IM MH - Adolescent MH - Adult MH - Ampicillin/*analogs & derivatives MH - Humans MH - Molar, Third/*surgery MH - Nitroimidazoles/*therapeutic use MH - Pivampicillin/*therapeutic use MH - Placebos MH - *Premedication MH - Surgical Wound Infection/prevention & control MH - Tinidazole/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1987/04/01 00:00 MHDA- 1987/04/01 00:01 CRDT- 1987/04/01 00:00 PHST- 1987/04/01 00:00 [pubmed] PHST- 1987/04/01 00:01 [medline] PHST- 1987/04/01 00:00 [entrez] AID - 10.1016/s0901-5027(87)80126-1 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1987 Apr;16(2):171-4. doi: 10.1016/s0901-5027(87)80126-1. PMID- 11862898 OWN - NLM STAT- MEDLINE DCOM- 20020327 LR - 20111117 IS - 0035-1768 (Print) IS - 0035-1768 (Linking) VI - 102 IP - 6 DP - 2001 Nov TI - [Should the lingual nerve be protected during germectomy? A prospective study apropos of 300 procedures]. PG - 299-303 AB - PURPOSE: Lingual nerve damage is one of the main complications of mandibular third molar removal. In literature, the series published are heterogeneous so we have decided to study the importance of the lingual protection only during germectomies (wisdom teeth without root formation). METHODS: We conducted a randomized prospective study in 300 germectomies, operated by the same skilled surgeon. These 300 third molar removals have been divided in two groups, one with lingual nerve protection and one without. RESULTS: Lingual nerve injuries following germectomies, with or without lingual protection was 0%. CONCLUSION: In germectomies, one can avoid lingual protection. FAU - Thiery, G AU - Thiery G AD - Service de Stomatologie-Chirurgie Maxillo-Faciale, Pr J.L. Blanc, CHU Timone, 13385 Marseille. FAU - Chossegros, C AU - Chossegros C FAU - Paris, J AU - Paris J FAU - Guyot, L AU - Guyot L FAU - Cheynet, F AU - Cheynet F FAU - Blanc, J L AU - Blanc JL LA - fre PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Faut-il protéger le nerf lingual au cours des germectomies? Etude prospective à propos de 300 interventions. PL - France TA - Rev Stomatol Chir Maxillofac JT - Revue de stomatologie et de chirurgie maxillo-faciale JID - 0201010 SB - D SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - Follow-Up Studies MH - Humans MH - Intraoperative Complications/prevention & control MH - Lingual Nerve/*pathology MH - Lingual Nerve Injuries MH - Male MH - Mandible/surgery MH - Molar, Third/surgery MH - Postoperative Complications/prevention & control MH - Prospective Studies MH - Sensation/physiology MH - Time Factors MH - Tooth Extraction/*adverse effects/instrumentation MH - Tooth Germ/*surgery MH - Touch/physiology EDAT- 2002/02/28 10:00 MHDA- 2002/03/28 10:01 CRDT- 2002/02/28 10:00 PHST- 2002/02/28 10:00 [pubmed] PHST- 2002/03/28 10:01 [medline] PHST- 2002/02/28 10:00 [entrez] PST - ppublish SO - Rev Stomatol Chir Maxillofac. 2001 Nov;102(6):299-303. PMID- 9738364 OWN - NLM STAT- MEDLINE DCOM- 19980923 LR - 20131121 IS - 0026-4970 (Print) IS - 0026-4970 (Linking) VI - 47 IP - 6 DP - 1998 Jun TI - [Management of postoperative pain in stomatology with ibuprofen L-arginine and naproxen]. PG - 287-92 AB - BACKGROUND: The aim of this prospective, randomized study is to compare the efficacy and safety of ibuprofen L-arginine and naproxen in the treatment of postoperative dental pain. METHODS: Seventy patients undergoing removal of impacted third molars were randomly allocated to receive 4 hours after surgery a single oral dose of either ibuprofen L-arginine 400 mg or naproxen 550 mg. Ten patients dropped out from the study because they took the study drug before the allowed time. Using a self-rating record, patients rated their pain and its relief for 1 hour after the drug administration. Remedication, if needed, and mean time of remedication were also recorded. RESULTS: A statistically significant reduction in pain scores with respect to the baseline values was recorded 5 minutes and 15 minutes after the drug administration in the ibuprofen L-arginine and in the naproxen-treated group, respectively. The summed pain intensity difference (SPID) over 60 minutes resulted significantly higher in the ibuprofen L-arginine than in the naproxen-treated group. A complete abolition of pain 60 minutes after medication was obtained in 12/28 patients (42.9%) in the ibuprofen L-arginine and in 5/32 patients (15.6%) in the naproxen-treated group, respectively (p = 0.04). Number of patients requiring remedication, mean time of remedication and drug related adverse effects did not significantly differ in the two treatment group. CONCLUSIONS: Global evaluation of the drugs by the patients showed ibuprofen more effective drug than naproxen. FAU - Polati, E AU - Polati E AD - Centro di Terapia del Dolore, Ospedale Policlinico di Verona, Università degli Studi, Verona. FAU - Finco, G AU - Finco G FAU - Salgarelli, A AU - Salgarelli A FAU - De Santis, D AU - De Santis D FAU - Gilli, E AU - Gilli E FAU - Barzoi, G AU - Barzoi G FAU - Gottin, L AU - Gottin L FAU - Ischia, S AU - Ischia S LA - ita PT - Clinical Trial PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Trattamento del dolore postoperatorio in odontostomatologia con ibuprofene L-arginina e naprossene. PL - Italy TA - Minerva Stomatol JT - Minerva stomatologica JID - 0421071 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 57Y76R9ATQ (Naproxen) RN - 94ZLA3W45F (Arginine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Arginine/*therapeutic use MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Informed Consent MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Naproxen/*therapeutic use MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction EDAT- 1998/09/17 00:00 MHDA- 1998/09/17 00:01 CRDT- 1998/09/17 00:00 PHST- 1998/09/17 00:00 [pubmed] PHST- 1998/09/17 00:01 [medline] PHST- 1998/09/17 00:00 [entrez] PST - ppublish SO - Minerva Stomatol. 1998 Jun;47(6):287-92. PMID- 2275651 OWN - NLM STAT- MEDLINE DCOM- 19910225 LR - 20190828 IS - 0045-0421 (Print) IS - 0045-0421 (Linking) VI - 35 IP - 4 DP - 1990 Aug TI - Does midazolam sedation in oral surgery affect the potency or duration of diflunisal analgesia? PG - 333-7 AB - A randomized cross-over study was carried out to determine whether midazolam in doses used for conscious sedation had any effect on the potency or duration of diflunisal, a non-narcotic analgesic used for postoperative pain in oral surgery. Thirty-two Hong Kong Chinese patients of either sex, aged between 16 and 28 years, were given either midazolam to supplement local anaesthesia or local anaesthesia alone at one visit and the alternative at the other visit, for surgical removal of bilateral symmetrically impacted third molars. Surgery was carried out on one side only at each visit. Diflunisal was given for postoperative pain relief. Midazolam had no effect on the potency or duration of action of diflunisal. Independent of the method, more patients had better pain relief following the second procedure than following the first, probably due to a degree of adaptation to the pain, at the second visit. FAU - Rodrigo, M R AU - Rodrigo MR AD - Department of Oral Surgery and Oral Medicine, University of Hong Kong. FAU - Rosenquist, J B AU - Rosenquist JB LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Australia TA - Aust Dent J JT - Australian dental journal JID - 0370612 RN - 7C546U4DEN (Diflunisal) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Local MH - *Conscious Sedation MH - Diflunisal/administration & dosage/*therapeutic use MH - Drug Interactions MH - Female MH - Humans MH - Male MH - Midazolam/*therapeutic use MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Time Factors MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery EDAT- 1990/08/01 00:00 MHDA- 1990/08/01 00:01 CRDT- 1990/08/01 00:00 PHST- 1990/08/01 00:00 [pubmed] PHST- 1990/08/01 00:01 [medline] PHST- 1990/08/01 00:00 [entrez] AID - 10.1111/j.1834-7819.1990.tb00781.x [doi] PST - ppublish SO - Aust Dent J. 1990 Aug;35(4):333-7. doi: 10.1111/j.1834-7819.1990.tb00781.x. PMID- 2702158 OWN - NLM STAT- MEDLINE DCOM- 19901121 LR - 20061115 IS - 0012-1029 (Print) IS - 0012-1029 (Linking) VI - 44 IP - 4 DP - 1989 Apr TI - [Insertion of collagen matrix into open bony defects]. PG - 240-3 AB - The use of collagen as a bone substitute was examined in a clinical study involving 70 patients. In a standardized operation impacted mandibular third molars were removed simultaneously. Collagen fleece was implanted in one osseous defect while the other defect was packed with iodoform gauze. Postoperative pain, swelling and complications were analyzed. There were significant differences between the two methods. The use of collagen fleece to obturate bony defects following surgical removal of impacked molars appeared to be of no advantage. On the contrary, there was a considerably higher rate of postoperative bleeding and complications. This could probably be related to the poor stability of the implanted material. FAU - Dehen, M AU - Dehen M FAU - Niederdellmann, H AU - Niederdellmann H FAU - Lachner, J AU - Lachner J LA - ger PT - Clinical Trial PT - Controlled Clinical Trial PT - English Abstract PT - Journal Article TT - Zur Einlagerung von Kollagenvlies in offene Knochendefekte. PL - Germany TA - Dtsch Zahnarztl Z JT - Deutsche zahnarztliche Zeitschrift JID - 2984745R RN - 9007-34-5 (Collagen) SB - D MH - Adult MH - Collagen/*adverse effects MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1989/04/01 00:00 MHDA- 1989/04/01 00:01 CRDT- 1989/04/01 00:00 PHST- 1989/04/01 00:00 [pubmed] PHST- 1989/04/01 00:01 [medline] PHST- 1989/04/01 00:00 [entrez] PST - ppublish SO - Dtsch Zahnarztl Z. 1989 Apr;44(4):240-3. PMID- 9327292 OWN - NLM STAT- MEDLINE DCOM- 19971113 LR - 20190920 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 26 IP - 5 DP - 1997 Oct TI - Stereophotogrammetric assessment of the effect of tenoxicam on facial swelling subsequent to third molar surgery. PG - 380-2 AB - The present study was undertaken in order to evaluate the effects of tenoxicam (Tilcotil), 20 mg daily, versus placebo on the inflammatory response induced in patients undergoing surgical removal of bilateral lower third molar teeth, using stereophotogrammetry to assess the degree of swelling. The results indicated that tenoxicam (20 mg/day) was no more effective than a nonactive placebo in modifying swelling in the first two postoperative days. FAU - Uçok, C AU - Uçok C AD - Department of Oral and Maxillofacial Surgery, Dental Faculty, Ankara University, Turkey. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 13T4O6VMAM (Piroxicam) RN - Z1R9N0A399 (tenoxicam) SB - D SB - IM MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Edema/pathology/*prevention & control MH - Evaluation Studies as Topic MH - *Face MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Photogrammetry MH - Piroxicam/administration & dosage/*analogs & derivatives/therapeutic use MH - Placebos MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1997/11/05 00:00 MHDA- 1997/11/05 00:01 CRDT- 1997/11/05 00:00 PHST- 1997/11/05 00:00 [pubmed] PHST- 1997/11/05 00:01 [medline] PHST- 1997/11/05 00:00 [entrez] AID - 10.1016/s0901-5027(97)80802-8 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1997 Oct;26(5):380-2. doi: 10.1016/s0901-5027(97)80802-8. PMID- 6832203 OWN - NLM STAT- MEDLINE DCOM- 19830527 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 24 IP - 1 DP - 1983 TI - Effect of preoperative paracetamol on pain after oral surgery. PG - 63-5 AB - A double-blind, randomized cross-over trial was carried out in 50 patients undergoing surgical removal of bilaterally impacted lower wisdom teeth. Surgery in each patient was performed twice and paracetamol 1000 mg was administered once preoperatively and once postoperatively. The time interval to additional analgesic intake and the pain intensity up to and at that time were assessed. There was no difference between the 2 treatments. It was concluded that preoperative paracetamol does not offer any clinical advantage in patients who undergo surgical removal of impacted lower wisdom teeth. FAU - Gustafsson, I AU - Gustafsson I FAU - Nyström, E AU - Nyström E FAU - Quiding, H AU - Quiding H LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 362O9ITL9D (Acetaminophen) SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Postoperative Care MH - Preoperative Care MH - Random Allocation EDAT- 1983/01/01 00:00 MHDA- 1983/01/01 00:01 CRDT- 1983/01/01 00:00 PHST- 1983/01/01 00:00 [pubmed] PHST- 1983/01/01 00:01 [medline] PHST- 1983/01/01 00:00 [entrez] AID - 10.1007/BF00613928 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1983;24(1):63-5. doi: 10.1007/BF00613928. PMID- 3859943 OWN - NLM STAT- MEDLINE DCOM- 19850821 LR - 20131121 IS - 0347-9994 (Print) IS - 0347-9994 (Linking) VI - 9 IP - 2 DP - 1985 TI - Effect of methylprednisolone on complications after removal of impacted mandibular third molars. PG - 65-9 AB - Bilateral impacted mandibular third molars were surgically removed in 20 healthy patients. The effects of methylprednisolone on postoperative healing was investigated in a double-blind, cross-over study. Some decrease in postoperative discomfort (swelling and trismus) was noted in the methylprednisolone group. No statistically significant difference was noted, however in comparison with a placebo group. FAU - Bystedt, H AU - Bystedt H FAU - Nordenram, A AU - Nordenram A LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Sweden TA - Swed Dent J JT - Swedish dental journal JID - 7706129 RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mandible MH - Methylprednisolone/pharmacology/*therapeutic use MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Random Allocation MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Wound Healing/drug effects EDAT- 1985/01/01 00:00 MHDA- 1985/01/01 00:01 CRDT- 1985/01/01 00:00 PHST- 1985/01/01 00:00 [pubmed] PHST- 1985/01/01 00:01 [medline] PHST- 1985/01/01 00:00 [entrez] PST - ppublish SO - Swed Dent J. 1985;9(2):65-9. PMID- 11830951 OWN - NLM STAT- MEDLINE DCOM- 20020708 LR - 20151119 IS - 0028-2200 (Print) IS - 0028-2200 (Linking) VI - 101 IP - 3 DP - 1994 Mar TI - [Treatment with soft laser. The effect on complaints after the removal of wisdom teeth in the mandible]. PG - 100-3 AB - In a placebo controlled double-blind randomized study the effect of low level laser therapy on postoperative complaints after removal of lower third molars was examined. Several parameters were investigated in two groups of patients; in one group low level laser was applied during and following third molar removal, in the other no active additional laser treatment was given. The results of this study show that therapeutic low level laser treatment could not statistically reduce the postoperative pain, swelling, trismus and function impairment after extraction of lower third molars. FAU - Braams, J W AU - Braams JW AD - Kliniek voor Mondziekten, Kaakchirurgie en Bijzondere Tandheelkunde, Academisch Ziekenhuis Groningen. FAU - Stegenga, B AU - Stegenga B FAU - Raghoebar, G M AU - Raghoebar GM FAU - Roodenburg, J L AU - Roodenburg JL FAU - van der Weele, L T AU - van der Weele LT LA - dut PT - Clinical Trial PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Behandeling met softlaser. Invloed op klachten na de verwijdering van verstandskiezen in de onderkaak. PL - Netherlands TA - Ned Tijdschr Tandheelkd JT - Nederlands tijdschrift voor tandheelkunde JID - 0400771 SB - D MH - Adolescent MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - *Low-Level Light Therapy MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Trismus/prevention & control EDAT- 1994/03/01 00:00 MHDA- 2002/07/09 10:01 CRDT- 1994/03/01 00:00 PHST- 1994/03/01 00:00 [pubmed] PHST- 2002/07/09 10:01 [medline] PHST- 1994/03/01 00:00 [entrez] PST - ppublish SO - Ned Tijdschr Tandheelkd. 1994 Mar;101(3):100-3. PMID- 356041 OWN - NLM STAT- MEDLINE DCOM- 19781018 LR - 20080221 VI - 74 IP - 1-2 DP - 1978 Feb-Apr TI - Comparison of the effectiveness of Astra 2167 and Dolorin in the relief of pain after removal of impacted mandibular third molar. PG - 18-22 FAU - Oikarinen, V J AU - Oikarinen VJ FAU - Leikomaa, T M AU - Leikomaa TM FAU - Lindqvist, K AU - Lindqvist K FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P FAU - Gustafsson, B AU - Gustafsson B LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Finland TA - Proc Finn Dent Soc JT - Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia JID - 0366632 RN - 0 (Analgesics) SB - D SB - IM MH - Adult MH - Analgesics/*therapeutic use MH - Clinical Trials as Topic MH - Female MH - Humans MH - Male MH - Mandible MH - Molar/surgery MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1978/02/01 00:00 MHDA- 1978/02/01 00:01 CRDT- 1978/02/01 00:00 PHST- 1978/02/01 00:00 [pubmed] PHST- 1978/02/01 00:01 [medline] PHST- 1978/02/01 00:00 [entrez] PST - ppublish SO - Proc Finn Dent Soc. 1978 Feb-Apr;74(1-2):18-22. PMID- 3882104 OWN - NLM STAT- MEDLINE DCOM- 19850327 LR - 20190718 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 158 IP - 1 DP - 1985 Jan 5 TI - A comparison of the analgesic effects of meptazinol and pentazocine following removal of impacted third molars. PG - 19-21 FAU - Griffiths, M J AU - Griffiths MJ FAU - Thomas, T A AU - Thomas TA LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Azepines) RN - 18Y7S5JKZD (Meptazinol) RN - RP4A60D26L (Pentazocine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental MH - *Azepines MH - Clinical Trials as Topic MH - Double-Blind Method MH - Humans MH - *Meptazinol MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/drug therapy MH - *Pentazocine MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1985/01/05 00:00 MHDA- 1985/01/05 00:01 CRDT- 1985/01/05 00:00 PHST- 1985/01/05 00:00 [pubmed] PHST- 1985/01/05 00:01 [medline] PHST- 1985/01/05 00:00 [entrez] AID - 10.1038/sj.bdj.4805525 [doi] PST - ppublish SO - Br Dent J. 1985 Jan 5;158(1):19-21. doi: 10.1038/sj.bdj.4805525. PMID- 3125269 OWN - NLM STAT- MEDLINE DCOM- 19880328 LR - 20190919 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 16 IP - 6 DP - 1987 Dec TI - Analgesic efficacy and tolerability of diflunisal in oral surgery. PG - 700-5 AB - A double-blind, completely randomized study was carried out on 169 patients to compare the analgesic efficacy and tolerability of diflunisal with that of Veralgin after surgical removal of impacted third molars. One group received 1000 mg diflunisal (Donobid, MSD) 2 h preoperatively and then 500 mg twice daily for 2.5 days, and the other group Veralgin (aminophenazon. 286 mg, barbital. 114 mg, aethylmorph. hydrochlorid. 20 mg, Orion), a fixed combination widely used in Finland, 1 tablet twice daily beginning 2 h prior to operation. Visual analogue scales were used to estimate pain. Diflunisal was found to be superior in relieving pain in the early postoperative period, the associated frequency of adverse clinical experiences was lower and the final evaluation of analgesic efficacy by both the patients and the investigators, was in its favour. The study confirms that postoperative pain after third molar surgery can be controlled well without the use of mainly centrally acting combination analgesics. FAU - Kinnunen, J AU - Kinnunen J AD - Department of Oral and Maxillofacial Surgery, University of Oulu, Finland. FAU - Pernu, H AU - Pernu H LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Barbiturates) RN - 0 (Drug Combinations) RN - 0 (Morphine Derivatives) RN - 0 (Salicylates) RN - 01704YP3MO (Aminopyrine) RN - 122114-16-3 (Veralgin) RN - 5WZ53ENE2P (Barbital) RN - 7C546U4DEN (Diflunisal) RN - RWO67D87EU (Ethylmorphine) SB - D SB - IM MH - Adult MH - Aminopyrine/administration & dosage/*therapeutic use MH - Barbital/administration & dosage/*therapeutic use MH - Barbiturates/*therapeutic use MH - Clinical Trials as Topic MH - Diflunisal/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Administration Schedule MH - Drug Combinations/administration & dosage/therapeutic use MH - Ethylmorphine/administration & dosage/*therapeutic use MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Morphine Derivatives/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Random Allocation MH - Salicylates/*therapeutic use MH - Tooth Extraction/*adverse effects EDAT- 1987/12/01 00:00 MHDA- 1987/12/01 00:01 CRDT- 1987/12/01 00:00 PHST- 1987/12/01 00:00 [pubmed] PHST- 1987/12/01 00:01 [medline] PHST- 1987/12/01 00:00 [entrez] AID - 10.1016/s0901-5027(87)80056-5 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1987 Dec;16(6):700-5. doi: 10.1016/s0901-5027(87)80056-5. PMID- 2135254 OWN - NLM STAT- MEDLINE DCOM- 19920528 LR - 20131121 IS - 0343-3137 (Print) IS - 0343-3137 (Linking) VI - 14 IP - 6 DP - 1990 Nov-Dec TI - [Combined analgetic drug treatment with ibuprofen after 3rd molar osteotomy]. PG - 442-6 AB - In a placebo-controlled double-blind study using 3 x 400 mg ibuprofen during the surgical removal of impacted and dislocated third molars, a pain reduction of 64% (p = 0.05) as against the placebo control group could be demonstrated on the day of surgery and the first postoperative day. In view of the published results of a double-blind study on the reduction of cheek swelling using dexamethasone, the perioperative combination of 3 x 600 mg ibuprofen with 2 x 6 mg dexamethasone seems to be helpful in reliably preventing pain and swelling after dental surgery. FAU - Schmelzeisen, R AU - Schmelzeisen R AD - Klinik und Poliklinik für Mund-, und Gesichtschirurgie, Medizinische Hochschule Hannover. FAU - Buchweitz, I K AU - Buchweitz IK FAU - Fricke, A AU - Fricke A FAU - Frölich, J AU - Frölich J LA - ger PT - Clinical Trial PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Medikamentöse analgetische Kombinationsbehandlung nach Weisheitszahnosteotomien mit Ibuprofen. PL - Germany TA - Dtsch Z Mund Kiefer Gesichtschir JT - Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie JID - 8700280 RN - 7S5I7G3JQL (Dexamethasone) RN - WK2XYI10QM (Ibuprofen) SB - D MH - Adolescent MH - Adult MH - Dexamethasone/therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Tooth, Impacted/*surgery EDAT- 1990/11/01 00:00 MHDA- 1990/11/01 00:01 CRDT- 1990/11/01 00:00 PHST- 1990/11/01 00:00 [pubmed] PHST- 1990/11/01 00:01 [medline] PHST- 1990/11/01 00:00 [entrez] PST - ppublish SO - Dtsch Z Mund Kiefer Gesichtschir. 1990 Nov-Dec;14(6):442-6. PMID- 2257796 OWN - NLM STAT- MEDLINE DCOM- 19910131 LR - 20131121 IS - 0012-1029 (Print) IS - 0012-1029 (Linking) VI - 45 IP - 1 DP - 1990 Jan TI - [The efficacy of paracetamol (Tylenol) and acetyl salicylic acid (Aspirin) in treating postoperative pain]. PG - 23-6 AB - In a randomized, double-center, double-blind, parallel group study the analgesic effect of a single dose of paracetamol (1000 mg) and acetyl salicylic acid (1000 mg) was compared with placebo in patients with moderate to severe postoperative pain following the surgical removal of a wisdom tooth. The most important finding was the statistically significantly shorter period until the onset of the action of paracetamol as against acetyl salicylic acid. FAU - Lehnert, S AU - Lehnert S AD - Poliklinik für Chirurgische Zahn-, Mund- und Kieferheilkunde der Universität Bonn. FAU - Reuther, J AU - Reuther J FAU - Wahl, G AU - Wahl G FAU - Barthel, K AU - Barthel K LA - ger PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial TT - Wirksamkeit von Paracetamol (Tylenol) und Acetylsalizylsäure (Aspirin) bei postoperativen Schmerzen. PL - Germany TA - Dtsch Zahnarztl Z JT - Deutsche zahnarztliche Zeitschrift JID - 2984745R RN - 362O9ITL9D (Acetaminophen) RN - R16CO5Y76E (Aspirin) SB - D MH - Acetaminophen/pharmacology/*therapeutic use MH - Adolescent MH - Adult MH - Aged MH - Aspirin/pharmacology/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] PST - ppublish SO - Dtsch Zahnarztl Z. 1990 Jan;45(1):23-6. PMID- 1732485 OWN - NLM STAT- MEDLINE DCOM- 19920227 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 50 IP - 2 DP - 1992 Feb TI - Postoperative pain prevention by a single-dose formulation of diclofenac producing a steady plasma concentration. PG - 124-7 AB - The preoperative single-dose oral administration of a combination of rapid- and slow-release diclofenac (Voltaren, Ciba-Geigy, Basel, Switzerland) preparation in a placebo-controlled trial proved to be more effective in postoperative pain prevention following third molar removal than the combination of intramuscular diclofenac and an oral depot formula. FAU - Hyrkäs, T AU - Hyrkäs T AD - Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland. FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P FAU - Oikarinen, V J AU - Oikarinen VJ FAU - Hampf, G AU - Hampf G LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Delayed-Action Preparations) RN - 0 (Placebos) RN - 144O8QL0L1 (Diclofenac) SB - AIM SB - D SB - IM MH - Adult MH - Delayed-Action Preparations MH - Diclofenac/administration & dosage/adverse effects/*therapeutic use MH - Eating MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible/physiology MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - *Premedication MH - Tooth Extraction/adverse effects EDAT- 1992/02/01 00:00 MHDA- 1992/02/01 00:01 CRDT- 1992/02/01 00:00 PHST- 1992/02/01 00:00 [pubmed] PHST- 1992/02/01 00:01 [medline] PHST- 1992/02/01 00:00 [entrez] AID - 0278-2391(92)90356-5 [pii] AID - 10.1016/0278-2391(92)90356-5 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1992 Feb;50(2):124-7. doi: 10.1016/0278-2391(92)90356-5. PMID- 8286287 OWN - NLM STAT- MEDLINE DCOM- 19940222 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 31 IP - 6 DP - 1993 Dec TI - Preoperative intravenous diclofenac for postoperative pain prevention in outpatients. PG - 351-4 AB - Fifty patients undergoing a standard removal of an impacted lower third molar were given a single dose of 75 mg sodium diclofenac or saline (placebo) intravenously before operation, on a double-blind basis. Pain was measured postoperatively by means of a visual analogue scale hourly for the first 8 h and during the first and second days after operation. Administration of diclofenac resulted in greater pain relief than administration of placebo for the first 3 h after surgery, whereafter the treatments did not differ. The results suggest that intravenous preoperative diclofenac may be useful in some clinical situations but generally it probably offers little benefit over the corresponding oral treatment. FAU - Hyrkäs, T AU - Hyrkäs T AD - Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland. FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P FAU - Oikarinen, V J AU - Oikarinen VJ FAU - Paakkari, I AU - Paakkari I LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 144O8QL0L1 (Diclofenac) SB - D SB - IM MH - Adult MH - Ambulatory Surgical Procedures MH - Analysis of Variance MH - Diclofenac/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Infusions, Intravenous MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Preanesthetic Medication MH - Time Factors MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery EDAT- 1993/12/01 00:00 MHDA- 1993/12/01 00:01 CRDT- 1993/12/01 00:00 PHST- 1993/12/01 00:00 [pubmed] PHST- 1993/12/01 00:01 [medline] PHST- 1993/12/01 00:00 [entrez] AID - 10.1016/0266-4356(93)90189-4 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1993 Dec;31(6):351-4. doi: 10.1016/0266-4356(93)90189-4. PMID- 3296542 OWN - NLM STAT- MEDLINE DCOM- 19870721 LR - 20041117 IS - 0044-1651 (Print) IS - 0044-1651 (Linking) VI - 38 IP - 1 DP - 1987 Jan 9 TI - [Prevention of swelling with alph-intern: double blind study following surgical removal of the 3d molars]. PG - 14-7 FAU - Keller, U AU - Keller U LA - ger PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Schwellungsprophylaxe mit alph-intern: Doppelblindstudie nach operativer Weisheitszahnentfernung. PL - Germany TA - Zahnarztl Prax JT - Zahnarztliche Praxis JID - 0413626 RN - 0 (Anti-Inflammatory Agents) RN - EC 3.4.- (Peptide Hydrolases) SB - D MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*therapeutic use MH - Double-Blind Method MH - Edema/*prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Peptide Hydrolases/*therapeutic use MH - Tooth Extraction/*adverse effects EDAT- 1987/01/09 00:00 MHDA- 1987/01/09 00:01 CRDT- 1987/01/09 00:00 PHST- 1987/01/09 00:00 [pubmed] PHST- 1987/01/09 00:01 [medline] PHST- 1987/01/09 00:00 [entrez] PST - ppublish SO - Zahnarztl Prax. 1987 Jan 9;38(1):14-7. PMID- 12596735 OWN - NLM STAT- MEDLINE DCOM- 20030618 LR - 20131121 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 194 IP - 2 DP - 2003 Jan 25 TI - Evidence for continuing warfarin during dental extractions. PG - 65 FAU - Gibbons, A J AU - Gibbons AJ FAU - Sugar, A W AU - Sugar AW LA - eng PT - Comment PT - Letter PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - D SB - IM CON - Br Dent J. 1983 Nov 5;155(9):308-10. PMID: 6605757 MH - Anticoagulants/adverse effects/*therapeutic use MH - Humans MH - International Normalized Ratio MH - Oral Hemorrhage/prevention & control MH - Postoperative Hemorrhage/prevention & control MH - Randomized Controlled Trials as Topic/statistics & numerical data MH - *Tooth Extraction MH - Warfarin/adverse effects/*therapeutic use EDAT- 2003/02/25 04:00 MHDA- 2003/06/19 05:00 CRDT- 2003/02/25 04:00 PHST- 2003/02/25 04:00 [pubmed] PHST- 2003/06/19 05:00 [medline] PHST- 2003/02/25 04:00 [entrez] PST - ppublish SO - Br Dent J. 2003 Jan 25;194(2):65. PMID- 385518 OWN - NLM STAT- MEDLINE DCOM- 19791218 LR - 20071115 IS - 0340-0026 (Print) IS - 0340-0026 (Linking) VI - 17 IP - 7 DP - 1979 Jul TI - Evaluation of antihemorrhagic activity of V. F. PG - 324-6 AB - In the prophylaxis of surgical interventions performed in the Dental Clinic for dental avulsions under general anesthesia, the V. F. (peptides deriving from the enzymatic degradation of bovine Factor VIII) has been shown to be particularly active in the reduction of the quantity of blood lost per tooth, corresponding to a reduction in blood loss of an average of 40% to 45%. The "double blind" experiment confirmed a significant hemostatic capacity of the preparation. V. F. in extremely small doses (1 mg/day) divided into two daily, oral administrations, isn't toxic, isn't habit forming and doesn't provoke immunological reactions. On the basis of its positive characteristics (diminution of blood lost without alteration of the parameters of coagulation or platelet aggregation), V. F. seems to be the preparation of choice for the treatment of hemorrhagic diathesis not accompanied by coagulation defect, and also as a preventive measure in minor surgical interventions where small vessels are involved and hemostasis cannot be achieved surgically. FAU - Marcucci, M AU - Marcucci M FAU - Aliboni, E AU - Aliboni E FAU - Previtera, A AU - Previtera A FAU - Martini, A AU - Martini A LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Germany TA - Int J Clin Pharmacol Biopharm JT - International journal of clinical pharmacology and biopharmacy JID - 7505527 RN - 0 (Peptides) RN - 9001-27-8 (Factor VIII) SB - IM MH - Clinical Trials as Topic MH - Double-Blind Method MH - Factor VIII/*therapeutic use MH - Female MH - Humans MH - Male MH - Oral Hemorrhage/*drug therapy/prevention & control MH - Peptides/*therapeutic use MH - *Tooth Extraction EDAT- 1979/07/01 00:00 MHDA- 1979/07/01 00:01 CRDT- 1979/07/01 00:00 PHST- 1979/07/01 00:00 [pubmed] PHST- 1979/07/01 00:01 [medline] PHST- 1979/07/01 00:00 [entrez] PST - ppublish SO - Int J Clin Pharmacol Biopharm. 1979 Jul;17(7):324-6. PMID- 1820675 OWN - NLM STAT- MEDLINE DCOM- 19920806 LR - 20161123 IS - 0011-8516 (Print) IS - 0011-8516 (Linking) VI - 46 IP - 12 DP - 1991 Dec TI - [Evaluation of Tenoxicam for control of postoperative pain and swelling following surgical removal of impacted molars]. PG - 575-8 AB - This study reports on the efficacy of a single preoperative administration of Tenoxicam (20 mg intramuscular) after removal of two or more impacted molars. The recording of postoperative pain and swelling on a categorical and linear scale showed that there were no significant differences between the experimental and control groups. However, a significant reduction in pain was noted on the first postoperative day. We concluded that a single dose of Tenoxicam administered one hour preoperatively did have a significant analgesic effect, even though there was no significant reduction in postoperative swelling. Patients who did not have the injection had a 5.37 greater change of having more postoperative pain than those who were injected with Tenoxicam. FAU - van Jaarsveld, C AU - van Jaarsveld C AD - Departement Farmakologie, Universiteit van Pretoria. FAU - Groeneveld, H T AU - Groeneveld HT LA - afr PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Evaluering van Tenoxicam ten opsigte van die postoperatiewe pynverligting en swelling na die chirurgiese verwydering van geimpakteerde molare. PL - South Africa TA - J Dent Assoc S Afr JT - The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika JID - 7505600 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - Z1R9N0A399 (tenoxicam) SB - D MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Piroxicam/*analogs & derivatives/therapeutic use MH - Tooth, Impacted/*surgery EDAT- 1991/12/01 00:00 MHDA- 1991/12/01 00:01 CRDT- 1991/12/01 00:00 PHST- 1991/12/01 00:00 [pubmed] PHST- 1991/12/01 00:01 [medline] PHST- 1991/12/01 00:00 [entrez] PST - ppublish SO - J Dent Assoc S Afr. 1991 Dec;46(12):575-8. PMID- 309931 OWN - NLM STAT- MEDLINE DCOM- 19790226 LR - 20131121 IS - 0022-3255 (Print) IS - 0022-3255 (Linking) VI - 36 IP - 12 DP - 1978 Dec TI - Clinical effects of aspirin and acetaminophen on hemostasis after exodontics. PG - 944-7 AB - The effects of aspirin and acetaminophen on postextraction hemostasis were evaluated in a double-blind study in a group of 43 patients; 20 received aspirin and 23 received acetaminophen. No significant difference was found in the observed postsurgical alveolus bleeding times or the patients' reported length of postoperative bleeding. However, Ivy bleeding times taken after the ingestion of 80 grains of medication showed an elevation in 75% of the aspirin users and in 60% of the acetaminophen group; the mean change in bleeding times was 2.75 times greater in the aspirin group. FAU - Pawlak, D F AU - Pawlak DF FAU - Itkin, A B AU - Itkin AB FAU - Lapeyrolerie, F M AU - Lapeyrolerie FM FAU - Zweig, B AU - Zweig B LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Surg JT - Journal of oral surgery (American Dental Association : 1965) JID - 8302454 RN - 362O9ITL9D (Acetaminophen) RN - R16CO5Y76E (Aspirin) SB - AIM SB - D SB - IM MH - Acetaminophen/*pharmacology MH - Aspirin/*pharmacology MH - Blood Coagulation/drug effects MH - Blood Coagulation Tests MH - Blood Platelets/drug effects MH - Double-Blind Method MH - Hemostasis/*drug effects MH - Humans MH - Male MH - Oral Hemorrhage/physiopathology MH - *Tooth Extraction EDAT- 1978/12/01 00:00 MHDA- 1978/12/01 00:01 CRDT- 1978/12/01 00:00 PHST- 1978/12/01 00:00 [pubmed] PHST- 1978/12/01 00:01 [medline] PHST- 1978/12/01 00:00 [entrez] PST - ppublish SO - J Oral Surg. 1978 Dec;36(12):944-7. PMID- 4505409 OWN - NLM STAT- MEDLINE DCOM- 19720921 LR - 20131121 IS - 0007-117X (Print) IS - 0007-117X (Linking) VI - 9 IP - 3 DP - 1972 Mar TI - Penicillin--the duration of its activity in blood clots. PG - 222-7 FAU - Juniper, R P AU - Juniper RP LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Scotland TA - Br J Oral Surg JT - The British journal of oral surgery JID - 0400651 RN - 17R794ESYN (Penicillin G Procaine) RN - Q42T66VG0C (Penicillin G) SB - D SB - IM MH - *Blood Coagulation MH - Humans MH - Injections, Intramuscular MH - Penicillin G/analysis/*blood MH - Penicillin G Procaine/analysis/*blood MH - Premedication MH - Saliva/analysis MH - Surgical Wound Infection/prevention & control MH - *Tooth Extraction EDAT- 1972/03/01 00:00 MHDA- 1972/03/01 00:01 CRDT- 1972/03/01 00:00 PHST- 1972/03/01 00:00 [pubmed] PHST- 1972/03/01 00:01 [medline] PHST- 1972/03/01 00:00 [entrez] PST - ppublish SO - Br J Oral Surg. 1972 Mar;9(3):222-7. PMID- 24042066 OWN - NLM STAT- MEDLINE DCOM- 20141104 LR - 20140204 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 43 IP - 3 DP - 2014 Mar TI - Analgesic efficacy of lysine clonixinate plus tramadol versus tramadol in multiple doses following impacted third molar surgery. PG - 348-54 LID - S0901-5027(13)01070-9 [pii] LID - 10.1016/j.ijom.2013.08.003 [doi] AB - This study compared the analgesic and anti-inflammatory efficacy, trismus control, and tolerability of the combination of lysine clonixinate and tramadol (LCT) versus tramadol (T) alone after surgical removal of impacted mandibular third molars. This study was a double-blind, randomized clinical trial, including two study groups of 20 patients each, who exhibited acute pain subsequent to surgical extraction of two mandibular third molars. Pain intensity was quantified over a 96-h period using a visual analogue scale and a 5-point verbal rating scale. Secondary indicators of analgesic and anti-inflammatory efficacy, trismus control, and tolerability were determined. Patients administered LCT exhibited better therapeutic effects that those administered T. Fifty percent of patients in the LCT group rated this therapy as 'excellent analgesia' compared with only 10% in the T group. The onset of the analgesic effect of LCT was significantly faster, without any therapeutic failures. There were no significant differences between the groups with regard to anti-inflammatory effect or trismus. The results of this study suggest that the postsurgical analgesic efficacy of LCT in combination (LC 125 mg + T 25 mg) is superior to that obtained with T alone, administered at the standard dose of 50 mg, for up to 96 h after the extraction of both impacted mandibular third molars. CI - Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved. FAU - Perez-Urizar, J AU - Perez-Urizar J AD - Department of Pharmacology, Faculty of Chemistry, Universidad Autónoma de San Luis Potosí, Mexico. FAU - Martínez-Rider, R AU - Martínez-Rider R AD - Department of Oral and Maxillofacial Surgery, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, Mexico. FAU - Torres-Roque, I AU - Torres-Roque I AD - Dixpertia Investigación Biofarmacéutica y Farmacológica SC, San Luis Potosí, Mexico. FAU - Garrocho-Rangel, A AU - Garrocho-Rangel A AD - Institutional Program in Engineering and Materials Sciences, Universidad Autónoma de San Luis Potosí, Mexico. FAU - Pozos-Guillen, A AU - Pozos-Guillen A AD - Basic Sciences Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, Mexico. Electronic address: apozos@uaslp.mx. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20130914 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics) RN - 0 (Analgesics, Opioid) RN - 06PW4M190R (lysine clonixinate) RN - 39J1LGJ30J (Tramadol) RN - K3Z4F929H6 (Lysine) RN - V7DXN0M42R (Clonixin) SB - D SB - IM MH - Adult MH - Analgesics/*therapeutic use MH - Analgesics, Opioid/*therapeutic use MH - Clonixin/*analogs & derivatives/therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Lysine/*analogs & derivatives/therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain Management MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth, Impacted/*surgery MH - Tramadol/*therapeutic use MH - Treatment Outcome MH - Trismus/prevention & control OTO - NOTNLM OT - Balanced analgesia OT - Lysine clonixinate OT - Third molar surgery OT - Tramadol EDAT- 2013/09/18 06:00 MHDA- 2014/11/05 06:00 CRDT- 2013/09/18 06:00 PHST- 2012/12/20 00:00 [received] PHST- 2013/07/20 00:00 [revised] PHST- 2013/08/09 00:00 [accepted] PHST- 2013/09/18 06:00 [entrez] PHST- 2013/09/18 06:00 [pubmed] PHST- 2014/11/05 06:00 [medline] AID - S0901-5027(13)01070-9 [pii] AID - 10.1016/j.ijom.2013.08.003 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2014 Mar;43(3):348-54. doi: 10.1016/j.ijom.2013.08.003. Epub 2013 Sep 14. PMID- 1886022 OWN - NLM STAT- MEDLINE DCOM- 19911007 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 49 IP - 9 DP - 1991 Sep TI - The effect of a chlorhexidine rinse on the incidence of alveolar osteitis following the surgical removal of impacted mandibular third molars. PG - 932-7 AB - A prospective randomized double-blind placebo-controlled study was conducted with 139 patients (278 bilaterally impacted mandibular third molars) to determine the effect of a perioperative 0.12% chlorhexidine gluconate rinse on the incidence of alveolar osteitis following surgical removal of impacted mandibular third molars. A statistically significant 60% reduction in the incidence of alveolar osteitis was obtained in the chlorhexidine group compared with the placebo group. In most subgroups analyzed, chlorhexidine was associated with at least a 50% reduction in alveolar osteitis compared with control groups. FAU - Larsen, P E AU - Larsen PE AD - Department of Oral and Maxillofacial Surgery, College of Dentistry, Ohio State University, Columbus 43210. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - R4KO0DY52L (Chlorhexidine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Chlorhexidine/*therapeutic use MH - Double-Blind Method MH - Dry Socket/epidemiology/*prevention & control MH - Female MH - Humans MH - Incidence MH - Male MH - Molar, Third MH - Prospective Studies MH - Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1991/09/01 00:00 MHDA- 1991/09/01 00:01 CRDT- 1991/09/01 00:00 PHST- 1991/09/01 00:00 [pubmed] PHST- 1991/09/01 00:01 [medline] PHST- 1991/09/01 00:00 [entrez] AID - 0278-2391(91)90055-Q [pii] AID - 10.1016/0278-2391(91)90055-q [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1991 Sep;49(9):932-7. doi: 10.1016/0278-2391(91)90055-q. PMID- 16094585 OWN - NLM STAT- MEDLINE DCOM- 20050901 LR - 20141120 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 63 IP - 8 DP - 2005 Aug TI - The analgesic efficacy of intravenous versus oral tramadol for preventing postoperative pain after third molar surgery. PG - 1162-8 AB - PURPOSE: The aim of this study was to compare the analgesic efficacy of single-dose preoperative intravenous versus oral tramadol for preventing pain after third molar surgery. PATIENTS AND METHODS: Seventy-two patients undergoing elective third molar surgery were randomized to receive either intravenous (n = 36) or oral (n = 36) tramadol 50 mg. The intravenous group received an oral placebo capsule followed by intravenous tramadol 50 mg preoperatively. The oral tramadol group received a 50-mg oral tramadol capsule followed by intravenous placebo saline preoperatively. In both groups, a standard intravenous sedation technique was administered and the impacted third molars were removed under local anesthesia. The difference in postoperative pain was assessed by 4 primary end points: hourly pain intensity as measured by a 100-mm visual analog scale for 8 hours, time to rescue analgesic, postoperative acetaminophen consumption, and a 5-point global assessment scale (0 = poor, 1 = fair, 2 = good, 3 = very good, and 4 = excellent). RESULTS: Throughout the 8-hour investigation period, patients reported significantly lower pain intensity scores in the intravenous versus oral group (15.9 +/- 9.6 mm versus 36.9 +/- 17.2 mm, P = .03). Patients also reported significantly longer time to rescue analgesic (7.0 hours versus 3.5 hours, P = .00001), lesser postoperative acetaminophen consumption (1,823 +/- 1,266 mg versus 3,558 +/- 1,418 mg, P = .000006), and better global assessment (2.6 +/- 0.9 versus 1.1 +/- 0.8, P = .01) for the intravenous versus oral group. CONCLUSIONS: We conclude that preoperative intravenous tramadol is superior to oral tramadol for preventing postoperative pain following third molar surgery. However, it should be noted that there is a difference in the bioavailability between the 2 formulations of up to 30%, which may explain the findings. FAU - Ong, Cliff K S AU - Ong CK AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore. cliffong@pacific.nat.sg FAU - Lirk, Phillip AU - Lirk P FAU - Tan, Juliana M H AU - Tan JM FAU - Sow, Belle W Y AU - Sow BW LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - 39J1LGJ30J (Tramadol) SB - AIM SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Administration, Oral MH - Adult MH - Analgesics, Non-Narcotic/therapeutic use MH - Analgesics, Opioid/*administration & dosage MH - Anesthesia, Dental MH - Anesthesia, Local MH - Conscious Sedation MH - Elective Surgical Procedures MH - Female MH - Follow-Up Studies MH - Humans MH - Injections, Intravenous MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Premedication MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Tramadol/*administration & dosage EDAT- 2005/08/12 09:00 MHDA- 2005/09/02 09:00 CRDT- 2005/08/12 09:00 PHST- 2005/08/12 09:00 [pubmed] PHST- 2005/09/02 09:00 [medline] PHST- 2005/08/12 09:00 [entrez] AID - S0278239105004763 [pii] AID - 10.1016/j.joms.2005.04.028 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2005 Aug;63(8):1162-8. doi: 10.1016/j.joms.2005.04.028. PMID- 9569797 OWN - NLM STAT- MEDLINE DCOM- 19980601 LR - 20131121 IS - 1018-5992 (Print) IS - 1018-5992 (Linking) VI - 2 IP - 4 DP - 1997 Sep TI - Clinical effects of diflunisal and paracetamol in impacted mandibular third molar surgery. PG - 673-81 AB - A double-blind, randomized, cross-over study to compare diflunisal and paracetamol for postoperative pain, swelling and trismus relief following impacted mandibular third molar surgery was designed. 25 patients received one of the drugs at one visit and the alternative at the other visit. First doses were given two hours preoperatively and continued twice daily for five days. The study was carried out to determine the effect of preoperatively used diflunisal on postoperative pain after surgical removal of the third molars as compared to paracetamol used in a similar manner. The degree of impaction, pain, swelling and mouth opening were assessed by standardized methods and possible adverse effects were also recorded separately. Statistical analysis was carried out by "Student's t test". (p < 0.01 statistically significant). FAU - Sençift, K AU - Sençift K AD - Hacettepe University, Faculty of Dentistry, Department of Oral Surgery, Ankara, Türkiye. FAU - Kir, S AU - Kir S FAU - Tuncer, M AU - Tuncer M LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Turkey TA - J Marmara Univ Dent Fac JT - Journal of Marmara University Dental Faculty JID - 9114162 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - 7C546U4DEN (Diflunisal) SB - D MH - Acetaminophen/adverse effects/*therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Cross-Over Studies MH - Diflunisal/adverse effects/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Preoperative Care MH - Tooth, Impacted/*surgery EDAT- 1998/05/07 00:00 MHDA- 1998/05/07 00:01 CRDT- 1998/05/07 00:00 PHST- 1998/05/07 00:00 [pubmed] PHST- 1998/05/07 00:01 [medline] PHST- 1998/05/07 00:00 [entrez] PST - ppublish SO - J Marmara Univ Dent Fac. 1997 Sep;2(4):673-81. PMID- 28666096 OWN - NLM STAT- MEDLINE DCOM- 20171109 LR - 20171109 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 75 IP - 11 DP - 2017 Nov TI - A Comparative Study on the Efficacy of Submucosal Injection of Dexamethasone Versus Methylprednisolone in Reducing Postoperative Sequelae After Third Molar Surgery. PG - 2278-2286 LID - S0278-2391(17)30610-9 [pii] LID - 10.1016/j.joms.2017.05.033 [doi] AB - PURPOSE: To compare the efficacy of preoperative submucosal injection of 4 mg of dexamethasone versus 40 mg of methylprednisolone in reducing postoperative sequelae after surgical removal of impacted mandibular third molars. PATIENTS AND METHODS: This prospective, randomized, double-blind study included 65 patients who required surgical removal of impacted mandibular third molars with Class II or position B impaction (Pell and Gregory classification). Patients were randomly assigned to 1 of 3 groups: dexamethasone, methylprednisolone, or placebo (control). Surgery was performed with patients under local anesthesia. Baseline measurements were obtained preoperatively, and subsequent assessments were made on postoperative day 1, 2, 5, and 7 to measure postoperative facial swelling by use of 2 linear measurements: interincisal mouth opening width and visual analog scale score for pain. The amount of analgesics consumed was recorded. Wound healing also was assessed on postoperative day 7. Descriptive and multivariate statistics were computed, and significance was set at P < .05. RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, χ(2) test) during the early postoperative days. CONCLUSIONS: The study findings suggest that a single preoperative dose of dexamethasone versus methylprednisolone was equally effective in reducing postoperative swelling and trismus. Pain control by these corticosteroids, however, was variable. CI - Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Lim, Daniel AU - Lim D AD - Lecturer, Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: daniel_khlim@hotmail.com. FAU - Ngeow, Wei Cheong AU - Ngeow WC AD - Professor, Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20170608 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) RN - X4W7ZR7023 (Methylprednisolone) SB - AIM SB - D SB - IM CIN - J Oral Maxillofac Surg. 2018 Jun;76(6):1141. PMID: 29596794 CIN - J Oral Maxillofac Surg. 2018 Jun;76(6):1141-1142. PMID: 29596795 MH - Adult MH - Anti-Inflammatory Agents/*administration & dosage MH - Dexamethasone/*administration & dosage MH - Double-Blind Method MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections MH - Male MH - Methylprednisolone/*administration & dosage MH - Molar, Third/*surgery MH - Mouth Mucosa MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult EDAT- 2017/07/01 06:00 MHDA- 2017/11/10 06:00 CRDT- 2017/07/01 06:00 PHST- 2016/12/29 00:00 [received] PHST- 2017/05/31 00:00 [revised] PHST- 2017/05/31 00:00 [accepted] PHST- 2017/07/01 06:00 [pubmed] PHST- 2017/11/10 06:00 [medline] PHST- 2017/07/01 06:00 [entrez] AID - S0278-2391(17)30610-9 [pii] AID - 10.1016/j.joms.2017.05.033 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2017 Nov;75(11):2278-2286. doi: 10.1016/j.joms.2017.05.033. Epub 2017 Jun 8. PMID- 8405018 OWN - NLM STAT- MEDLINE DCOM- 19931027 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 44 IP - 6 DP - 1993 TI - The analgesic efficacy of diclofenac dispersible and ibuprofen in postoperative pain after dental extraction. PG - 587-8 AB - We have compared single oral doses of drinkable diclofenac dispersible (50 mg) with ibuprofen (400 mg) and placebo in a randomized, double-blind, parallel-group trial in 127 adults complaining of at least moderately severe pain after removal of an impacted third molar. Within 40 min both diclofenac and ibuprofen produced significant pain relief that persisted for 6 h. There were no differences between diclofenac and ibuprofen in analgesic efficacy. FAU - Ahlström, U AU - Ahlström U AD - Department of Oral Surgery, Institute of Postgraduate Dental Education, Jönköping, Sweden. FAU - Bakshi, R AU - Bakshi R FAU - Nilsson, P AU - Nilsson P FAU - Wåhlander, L AU - Wåhlander L LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 144O8QL0L1 (Diclofenac) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Analgesia MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Molar, Third MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 10.1007/BF02440865 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1993;44(6):587-8. doi: 10.1007/BF02440865. PMID- 16003612 OWN - NLM STAT- MEDLINE DCOM- 20050726 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 63 IP - 7 DP - 2005 Jul TI - Is there a role for reconstructive techniques to prevent periodontal defects after third molar surgery? PG - 891-6 AB - PURPOSE: Among patients at high risk for second molar (M2) periodontal defects after third molar (M3) removal, does active treatment at the time of extraction, when compared with no treatment, alter the risk of postextraction M2 periodontal defects? MATERIALS AND METHODS: We used a prospective cohort study design and a sample composed of subjects at high risk for developing M2 periodontal defects after M3 extraction, that is, age > or = 26 years, pre-existing periodontal defects (attachment level [AL] > or = 3 mm), and mesioangular or horizontal M3 impaction. The predictor variable was treatment status of the M3 extraction site. The M3 extraction sites were reconstructed with demineralized bone powder (DBP), bioresorbable guided tissue regeneration (GTR) therapy, or no treatment. The outcome variable was ALs measured at the M2 distobuccal line angle preoperatively and 26 weeks after extraction. Appropriate univariate, bivariate, and multivariate statistics were computed, and statistical significance was set at a value P < .05. RESULTS: The cohort was composed of 12 subjects contributing 18 high-risk M3s. Twenty-six weeks after M3 removal, the ALs for GTR-treated (3.0 +/- 1.2 mm), DBP-treated (1.4 +/- 0.5 mm), and control (3.8 +/- 0.9) M3 sites were statistically significantly different ( P = .002). Tukey post-hoc comparisons revealed a statistically significant difference between control and DBP ALs ( P = .001) and GTR-treated and DBP-treated ALs ( P = .037). There was no statistically significant difference in ALs between control and GTR-treated M3s ( P = .35). CONCLUSIONS: The results of this study suggest that subjects at high risk for developing M2 periodontal defects after M3 removal may benefit from the use of DBP placed at the time of M3 extraction to enhance periodontal healing. FAU - Dodson, Thomas B AU - Dodson TB AD - Department of Oral and Maxillofacial Surgery, Massatusetts General Hospital, Boston, MA 02114, USA. tbdodson@partners.org LA - eng GR - K24-DE00448/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adult MH - Alveolar Bone Loss/etiology/*prevention & control MH - Bone Matrix/transplantation MH - Bone Transplantation/*methods MH - Female MH - Guided Tissue Regeneration, Periodontal/*methods MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Multivariate Analysis MH - *Oral Surgical Procedures MH - Periodontal Attachment Loss/prevention & control MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth Socket/surgery MH - Treatment Outcome EDAT- 2005/07/09 09:00 MHDA- 2005/07/27 09:00 CRDT- 2005/07/09 09:00 PHST- 2005/07/09 09:00 [pubmed] PHST- 2005/07/27 09:00 [medline] PHST- 2005/07/09 09:00 [entrez] AID - S0278239105003228 [pii] AID - 10.1016/j.joms.2005.03.003 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2005 Jul;63(7):891-6. doi: 10.1016/j.joms.2005.03.003. PMID- 9395803 OWN - NLM STAT- MEDLINE DCOM- 19980130 LR - 20200825 IS - 0304-4602 (Print) IS - 0304-4602 (Linking) VI - 26 IP - 4 DP - 1997 Jul TI - Preoperative versus postoperative pethidine for extraction of impacted third molars. PG - 426-9 AB - We have studied the pre-emptive analgesic effects of pethidine by comparing its analgesic effects given before or immediately after operation in a randomized, double-blind study of 40 patients undergoing removal of bilateral impacted third molars under general anaesthesia. Group 1 patients received pethidine 50 mg as a 1 ml injection 1 to 2 hours before operation and normal saline 1 ml intramuscularly immediately after surgery. Group 2 patients received normal saline 1 ml intramuscularly before operation and pethidine 50 mg as a 1 ml injection immediately after surgery. Outcome measures included perception of pain on a visual analogue scale (VAS), the number of patients who required postoperative pethidine, time to first postoperative pethidine injection and total dose of pethidine given. Four patients in group 1 compared to 8 in group 2 required postoperative pethidine but this was not statistically significant. The VAS scores, time to first postoperative pethidine injection and total dose of pethidine also did not differ significantly between the 2 groups. We concluded that preoperative administration of pethidine intramuscularly did not confer additional analgesic effects compared with a similar dose given after surgery. FAU - Chew, S T AU - Chew ST AD - Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore. FAU - Low, T C AU - Low TC LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Singapore TA - Ann Acad Med Singap JT - Annals of the Academy of Medicine, Singapore JID - 7503289 RN - 0 (Analgesics, Opioid) RN - 9E338QE28F (Meperidine) SB - IM MH - Adult MH - Analgesics, Opioid/*administration & dosage MH - Chi-Square Distribution MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Meperidine/*administration & dosage MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Postoperative Care MH - Preoperative Care MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 1997/07/01 00:00 MHDA- 1997/12/13 00:01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/12/13 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] PST - ppublish SO - Ann Acad Med Singap. 1997 Jul;26(4):426-9. PMID- 8629744 OWN - NLM STAT- MEDLINE DCOM- 19960627 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 41 IP - 1 DP - 1994 TI - Effective postoperative pain prevention through administration of bupivacaine and diclofenac. PG - 6-10 AB - The efficacies of bupivacaine and lidocaine together with a preoperatively administered single-dose oral combination of normal- and sustained-release preparations of diclofenac in preventing postoperative pain after third molar removal were compared in a double-blind crossover study. Bilaterally impacted lower third molars were removed in two sessions. Each patient was given one type of local anesthetic on one session and the other in the second. Pain was recorded using a visual analog scale. When the diclofenac combination (150 mg) was given before the operation, postoperative analgesia was better with bupivacaine plus diclofenac than with lidocaine plus diclofenac. Twenty-five out of 40 patients preferred bupivacaine to lidocaine for local anesthesia. It is possible to achieve effective postoperative pain prevention by combining bupivacaine and preoperative normal- and sustained-release preparations of diclofenac. FAU - Hyrkäs, T AU - Hyrkäs T AD - Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland. FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P FAU - Oikarinen, V J AU - Oikarinen VJ FAU - Paakkari, I AU - Paakkari I LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Delayed-Action Preparations) RN - 0 (Drug Combinations) RN - 144O8QL0L1 (Diclofenac) RN - 98PI200987 (Lidocaine) RN - Y8335394RO (Bupivacaine) SB - D MH - Adult MH - Analysis of Variance MH - Anesthesia, Dental/*methods MH - Anesthesia, Local/*methods MH - Anesthetics, Local/*administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Bupivacaine/*administration & dosage MH - Chi-Square Distribution MH - Cross-Over Studies MH - Delayed-Action Preparations MH - Diclofenac/*administration & dosage MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Lidocaine/administration & dosage MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Patient Satisfaction MH - Preanesthetic Medication MH - Tooth Extraction MH - Tooth, Impacted/surgery PMC - PMC2148714 EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] PST - ppublish SO - Anesth Prog. 1994;41(1):6-10. PMID- 8308619 OWN - NLM STAT- MEDLINE DCOM- 19940316 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 52 IP - 3 DP - 1994 Mar TI - The anxiolytic effects of intravenous sedation using midazolam alone or in multiple drug techniques. PG - 219-24; discussion 225 AB - This study examines four drug combinations (midazolam, midazolam-midazolam, fentanyl-midazolam, and fentanyl-midazolam-methohexital) in a placebo-controlled double-blind clinical trial of intravenous sedation. It tests the hypothesis that there is no difference between the anxiolytic effect of the four combinations when compared with a saline placebo. Subjects were 207 mildly anxious young adults having their third molars removed. Cognitive measures of anxiety increased from preoperative levels in the placebo and both midazolam groups (P < .05). The anxiety response remained the same in the fentanyl-midazolam and fentanyl-midazolam-methohexital groups (P > .05). The level of successful anxiolysis ranged from 24% in the placebo group to 74% in the barbiturate group. Using the log likelihood method, comparisons suggest that the drug groups (from midazolam alone to the methohexital combination) have increasingly positive anxiolytic effects even when controlling for the effects of dental fear and intraoperative pain. The fentanyl-midazolam group is 8.1 and the methohexital group is 9.0 times more likely to have had a favorable outcome than the placebo group. Additional analyses of behavioral measures of anxiety yielded parallel results. Global evaluations after surgery were related to the success of anxiolysis for subjects in the active drug conditions (P < .05). FAU - Milgrom, P AU - Milgrom P AD - Department of Dental Public Health Sciences, University of Washington, Seattle 98195. FAU - Weinstein, P AU - Weinstein P FAU - Fiset, L AU - Fiset L FAU - Beirne, O R AU - Beirne OR LA - eng GR - N01-DE-72569/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Drug Combinations) RN - E5B8ND5IPE (Methohexital) RN - R60L0SM5BC (Midazolam) RN - UF599785JZ (Fentanyl) SB - AIM SB - D SB - IM MH - Adult MH - Anesthesia, Dental/*methods MH - Chi-Square Distribution MH - Conscious Sedation/*methods MH - Dental Anxiety/*drug therapy MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Fentanyl/administration & dosage MH - Humans MH - Infusions, Intravenous MH - Logistic Models MH - Male MH - Manifest Anxiety Scale MH - Methohexital/administration & dosage MH - Midazolam/*administration & dosage MH - Molar, Third/surgery MH - Tooth Extraction EDAT- 1994/03/01 00:00 MHDA- 1994/03/01 00:01 CRDT- 1994/03/01 00:00 PHST- 1994/03/01 00:00 [pubmed] PHST- 1994/03/01 00:01 [medline] PHST- 1994/03/01 00:00 [entrez] AID - 0278-2391(94)90285-2 [pii] AID - 10.1016/0278-2391(94)90285-2 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1994 Mar;52(3):219-24; discussion 225. doi: 10.1016/0278-2391(94)90285-2. PMID- 17052637 OWN - NLM STAT- MEDLINE DCOM- 20061031 LR - 20131121 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 102 IP - 5 DP - 2006 Nov TI - The effects of tramadol added to articaine on anesthesia duration. PG - 614-7 AB - OBJECTIVE: In this study the effect of tramadol added to articaine on the duration of anesthetic effect in a mandibular blockade was evaluated. STUDY DESIGN: A double-blind, randomized, placebo-controlled clinical trial with patients experiencing pain after removal of an impacted mandibular third molar was conducted. Patients were randomly allocated into 2 groups: group C (n = 24), control (C), articaine 4%, 1:100:000 epinephrine, 1.5 cartridges (2.7 mL) and saline (1 mL) into surgical site; group T, articaine 4%, 1:100:000 epinephrine, 1.5 cartridges (2.7 mL) and tramadol (T) 50 mg (1 mL) into the surgical site. The difficulty of the removal procedure, duration of the operation, and sensory blockade were also evaluated. RESULTS: The duration of the anesthetic effect elicited by articaine in group T (246.0; 140-287) was significantly longer than that in group C (124.5; 79-154 min). CONCLUSION: Tramadol can be used as an adjunctive drug in the management of pain since it improves the quality of transoperative anesthesia. FAU - Pozos, Amaury J AU - Pozos AJ AD - Department of Surgery, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Mexico. apozos@uaslp.mx FAU - Martinez, Ricardo AU - Martinez R FAU - Aguirre, Patricia AU - Aguirre P FAU - Perez, Jose AU - Perez J LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20060727 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Analgesics, Opioid) RN - 0 (Anesthetics, Local) RN - 0 (Drug Combinations) RN - 39J1LGJ30J (Tramadol) RN - D3SQ406G9X (Carticaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesics, Opioid/*administration & dosage MH - Anesthesia, Dental/*methods MH - Anesthetics, Local/*administration & dosage MH - Carticaine/*administration & dosage MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Nerve Block/*methods MH - Statistics, Nonparametric MH - Time Factors MH - Tooth Extraction MH - Tooth, Impacted/surgery MH - Tramadol/*administration & dosage EDAT- 2006/10/21 09:00 MHDA- 2006/11/01 09:00 CRDT- 2006/10/21 09:00 PHST- 2005/09/13 00:00 [received] PHST- 2005/12/27 00:00 [revised] PHST- 2006/01/19 00:00 [accepted] PHST- 2006/10/21 09:00 [pubmed] PHST- 2006/11/01 09:00 [medline] PHST- 2006/10/21 09:00 [entrez] AID - S1079-2104(06)00028-X [pii] AID - 10.1016/j.tripleo.2006.01.017 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Nov;102(5):614-7. doi: 10.1016/j.tripleo.2006.01.017. Epub 2006 Jul 27. PMID- 15225946 OWN - NLM STAT- MEDLINE DCOM- 20040920 LR - 20201208 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 42 IP - 4 DP - 2004 Aug TI - A double-blind randomised controlled clinical trial of the effect of preoperative ibuprofen, diclofenac, paracetamol with codeine and placebo tablets for relief of postoperative pain after removal of impacted third molars. PG - 299-306 AB - We conducted a randomised double-blind placebo-controlled single-centre study to compare the effect of preoperative ibuprofen 600 mg, diclofenac 100 mg, paracetamol 1 g with codeine 60 mg or placebo (Vitamin C 50 mg) tablets for relief of postoperative pain in 119 patients who had day case operations under general anaesthesia for removal of impacted third molars. Patients were given the tablets 1 h before operation. Pain was assessed using visual analogue scales and verbal rating scales preoperatively at 15 and 30 min and 1 and 3 h postoperatively. After they had gone home, patients were contacted by telephone at 6 and 24 h postoperatively to find out whether they had any adverse effects from the analgesics. There was no significant difference in the extent of postoperative pain among the four groups, but the placebo group had significantly shorter times before their first request for postoperative analgesics (median 17 min, range 14-90) than the diclofenac group (median 32, range 15-150). Preoperative analgesics at the stated doses are effective in providing immediate postoperative pain control after operations on third molars. There were, however, some side-effects including nausea, vomiting, headaches, and gastrointestinal discomfort, but there were no significant differences among the active analgesic groups with respect to adverse events either shortly after operation or at 6 or 24 h. FAU - Joshi, Ameeta AU - Joshi A AD - Department of Oral and Maxillofacial Sciences, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, UK. ameeta.joshi@man.ac.uk FAU - Parara, Eleni AU - Parara E FAU - Macfarlane, Tatiana V AU - Macfarlane TV LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Analgesics) RN - 144O8QL0L1 (Diclofenac) RN - 362O9ITL9D (Acetaminophen) RN - PQ6CK8PD0R (Ascorbic Acid) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Acetaminophen/*therapeutic use MH - Adolescent MH - Adult MH - Aged MH - Analgesics/*therapeutic use MH - Ascorbic Acid/therapeutic use MH - Codeine/*therapeutic use MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Epidemiologic Methods MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Premedication MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Treatment Outcome EDAT- 2004/07/01 05:00 MHDA- 2004/09/21 05:00 CRDT- 2004/07/01 05:00 PHST- 2004/02/14 00:00 [accepted] PHST- 2004/07/01 05:00 [pubmed] PHST- 2004/09/21 05:00 [medline] PHST- 2004/07/01 05:00 [entrez] AID - S0266435604000397 [pii] AID - 10.1016/j.bjoms.2004.02.004 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2004 Aug;42(4):299-306. doi: 10.1016/j.bjoms.2004.02.004. PMID- 9787543 OWN - NLM STAT- MEDLINE DCOM- 19981106 LR - 20190709 IS - 0002-8177 (Print) IS - 0002-8177 (Linking) VI - 129 IP - 10 DP - 1998 Oct TI - Bacteremia and intraoral suture removal: can an antimicrobial rinse help? PG - 1455-61 AB - Recent studies have shown that bacteremia can result from the removal of intraoral sutures. The authors found that preprocedural use of an antimicrobial oral rinse (0.12 percent chlorhexidine) did not significantly reduce the incidence of bacteremia when compared with no rinse at all. Similarly, a significant relationship between bleeding and bacteremia was not apparent. Most of the positive cultures yielded low colony counts. The results support the rationale for the American Heart Association's 1997 recommendations for use of antibiotic prophylaxis to prevent bacteremia, as well as the importance of good oral hygiene in prevention efforts. FAU - Brown, A R AU - Brown AR AD - Department of Oral and Maxillofacial Surgery, University of Missouri-Kansas City, School of Dentistry 64108, USA. FAU - Papasian, C J AU - Papasian CJ FAU - Shultz, P AU - Shultz P FAU - Theisen, F C AU - Theisen FC FAU - Shultz, R E AU - Shultz RE LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Am Dent Assoc JT - Journal of the American Dental Association (1939) JID - 7503060 RN - 0 (Mouthwashes) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Adolescent MH - Adult MH - Antibiotic Prophylaxis/statistics & numerical data MH - Bacteremia/blood/etiology/*prevention & control MH - Chlorhexidine/*therapeutic use MH - Colony Count, Microbial MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Mouthwashes/*therapeutic use MH - Oral Hemorrhage/microbiology MH - Oral Hygiene/adverse effects MH - Single-Blind Method MH - Suture Techniques/*adverse effects MH - Tooth Extraction/*adverse effects EDAT- 1998/10/27 00:00 MHDA- 1998/10/27 00:01 CRDT- 1998/10/27 00:00 PHST- 1998/10/27 00:00 [pubmed] PHST- 1998/10/27 00:01 [medline] PHST- 1998/10/27 00:00 [entrez] AID - S0002-8177(15)60084-8 [pii] AID - 10.14219/jada.archive.1998.0081 [doi] PST - ppublish SO - J Am Dent Assoc. 1998 Oct;129(10):1455-61. doi: 10.14219/jada.archive.1998.0081. PMID- 23391033 OWN - NLM STAT- MEDLINE DCOM- 20150916 LR - 20131114 IS - 1559-2863 (Electronic) IS - 0361-7734 (Linking) VI - 38 IP - 6 DP - 2013 Nov-Dec TI - Fracture resistance of teeth restored with all-ceramic inlays and onlays: an in vitro study. PG - 626-34 LID - 10.2341/12-211-L [doi] AB - Fracture resistance of inlays and onlays may be influenced by the quantity of the dental structure removed and the restorative materials used. The purpose of this in vitro study was to evaluate the effects of two different cavity preparation designs and all-ceramic restorative materials on the fracture resistance of the tooth-restoration complex. Fifty mandibular third molar teeth were randomly divided into the following five groups: group 1: intact teeth (control); group 2: inlay preparations, lithium-disilicate glass-ceramic (IPS e.max Press, Ivoclar Vivadent AG, Schaan, Liechtenstein); group 3: inlay preparations, zirconia ceramic (ICE Zirkon, Zirkonzahn SRL, Gais, Italy); group 4: onlay preparations, lithium-disilicate glass-ceramic (IPS e.max Press); and group 5: onlay preparations, zirconia ceramic (ICE Zirkon). The inlay and onlay restorations were adhesively cemented with dual polymerizing resin cement (Variolink II, Ivoclar Vivadent AG). After thermal cycling (5° to 55°C × 5000 cycles), specimens were subjected to a compressive load until fracture at a crosshead speed of 0.5 mm/min. Statistical analyses were performed using one-way analysis of variance and Tukey HSD tests. The fracture strength values were significantly higher in the inlay group (2646.7 ± 360.4) restored with lithium-disilicate glass-ceramic than those of the onlay group (1673.6 ± 677) restored with lithium-disilicate glass-ceramic. The fracture strength values of teeth restored with inlays using zirconia ceramic (2849 ± 328) and onlays with zirconia ceramic (2796.3 ± 337.3) were similar to those of the intact teeth (2905.3 ± 398.8). In the IPS e.max Press groups, as the preparation amount was increased (from inlay to onlay preparation), the fracture resistance was decreased. In the ICE Zirkon ceramic groups, the preparation type did not affect the fracture resistance results. FAU - Saridag, S AU - Saridag S FAU - Sevimay, M AU - Sevimay M FAU - Pekkan, G AU - Pekkan G LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20130207 PL - United States TA - Oper Dent JT - Operative dentistry JID - 7605679 RN - 12001-21-7 (Dental Porcelain) SB - D MH - Dental Porcelain/*therapeutic use MH - Dental Stress Analysis MH - Humans MH - In Vitro Techniques MH - Inlays/*methods MH - Molar, Third MH - Tooth Fractures/*prevention & control EDAT- 2013/02/09 06:00 MHDA- 2015/09/17 06:00 CRDT- 2013/02/09 06:00 PHST- 2013/02/09 06:00 [entrez] PHST- 2013/02/09 06:00 [pubmed] PHST- 2015/09/17 06:00 [medline] AID - 10.2341/12-211-L [doi] PST - ppublish SO - Oper Dent. 2013 Nov-Dec;38(6):626-34. doi: 10.2341/12-211-L. Epub 2013 Feb 7. PMID- 7562165 OWN - NLM STAT- MEDLINE DCOM- 19951102 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 53 IP - 10 DP - 1995 Oct TI - Evaluation of topical viscous 2% lidocaine jelly as an adjunct during the management of alveolar osteitis. PG - 1140-4 AB - PURPOSE: This study evaluated the efficacy of topical viscous 2% lidocaine jelly for the alleviation of pain experienced during the instrumentation of mandibular third molar extraction sites diagnosed with alveolar osteitis and for pain relief during the postinstrumentation period. PATIENTS AND METHODS: Thirty adult patients with a diagnosis of alveolar osteitis in a mandibular third molar extraction site were included in this prospective, double-blind study. Each patient had their sutures removed, the socket irrigated, and 2% lidocaine jelly placed on the tip and side of the tongue to blind the patient against the test substances. The subjects were then randomly distributed into two groups. Group 1 had a nonactive jelly base placed into the socket 2 minutes prior to the placement of a standard obtundant dressing. Group 2 had viscous 2% lidocaine jelly placed into the socket in the same manner. Patients subjectively quantified their pain intensity pretreatment, during instrumentation, immediately postmanipulation, at 5-minute intervals to 30 minutes, and at 45 and 60 minutes. They also subjectively quantified their pain relief at each of the time intervals following instrumentation. RESULTS: There was no statistical difference between the pretreatment pain experienced by both groups. The use of 2% lidocaine jelly had a measurable (P = .056), but not statistically significant, effect on pain due to instrumentation. At every time interval thereafter, the use of 2% lidocaine jelly elicited a statistically significant (P < .05) decrease in pain perception, and a statistically significant increase in pain relief when compared with the inactive jelly. CONCLUSION: Topical viscous 2% lidocaine jelly is a useful adjunct during the treatment of alveolar osteitis, especially in the early (< or = 60 minutes) postinstrumentation period. FAU - Betts, N J AU - Betts NJ AD - Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia 19104-6003. FAU - Makowski, G AU - Makowski G FAU - Shen, Y H AU - Shen YH FAU - Hersh, E V AU - Hersh EV LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics) RN - 0 (Anesthetics, Local) RN - 0 (Ointments) RN - 0 (Placebos) RN - 98PI200987 (Lidocaine) SB - AIM SB - D SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Analgesics/*administration & dosage MH - Anesthetics, Local/*administration & dosage MH - Bandages MH - Double-Blind Method MH - Dry Socket/*therapy MH - Humans MH - Lidocaine/*administration & dosage MH - Middle Aged MH - Molar, Third/surgery MH - Ointments MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Placebos MH - Prospective Studies MH - Sex Factors MH - Therapeutic Irrigation MH - Time Factors MH - Tooth Extraction/adverse effects MH - Viscosity EDAT- 1995/10/01 00:00 MHDA- 1995/10/01 00:01 CRDT- 1995/10/01 00:00 PHST- 1995/10/01 00:00 [pubmed] PHST- 1995/10/01 00:01 [medline] PHST- 1995/10/01 00:00 [entrez] AID - S0278239195000103 [pii] AID - 10.1016/0278-2391(95)90619-3 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1995 Oct;53(10):1140-4. doi: 10.1016/0278-2391(95)90619-3. PMID- 12017904 OWN - NLM STAT- MEDLINE DCOM- 20020805 LR - 20131121 IS - 0028-8047 (Print) IS - 0028-8047 (Linking) VI - 98 IP - 431 DP - 2002 Mar TI - Effectiveness of tramadol as an analgesic in oral surgery. PG - 9-11 AB - In a randomised, double-blind, cross-over trial, 15 healthy, young patients undergoing surgical removal of bilateral, impacted, third-molar teeth received the analgesic tramadol 50 mg, as a single dose, either 2 hours prior or immediately before the surgical procedure. There were no differences in the post-operative pain levels or degree of trismus between the two methods of administration of tramadol (P > 0.05), suggesting absence of any pre-emptive analgesic effect for the drug in the dose studied. The prevalence of unwanted side effects such as nausea (37 percent) was high within the first 24 hours. FAU - Kumara, Rohana AU - Kumara R AD - Department of Stomatology, School of Dentistry, PO Box 647, Dunedin. FAU - Zacharias, Mathew AU - Zacharias M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - New Zealand TA - N Z Dent J JT - The New Zealand dental journal JID - 0401065 RN - 0 (Analgesics, Opioid) RN - 39J1LGJ30J (Tramadol) SB - D SB - IM MH - Adult MH - Analgesics, Opioid/*administration & dosage/adverse effects MH - Analysis of Variance MH - Chi-Square Distribution MH - Cross-Over Studies MH - Double-Blind Method MH - Drug Administration Schedule MH - Facial Pain/prevention & control MH - Humans MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Postoperative Nausea and Vomiting/etiology MH - Preoperative Care MH - *Tooth Extraction MH - Tramadol/*administration & dosage/adverse effects EDAT- 2002/05/23 10:00 MHDA- 2002/08/06 10:01 CRDT- 2002/05/23 10:00 PHST- 2002/05/23 10:00 [pubmed] PHST- 2002/08/06 10:01 [medline] PHST- 2002/05/23 10:00 [entrez] PST - ppublish SO - N Z Dent J. 2002 Mar;98(431):9-11. PMID- 29959306 OWN - NLM STAT- MEDLINE DCOM- 20190107 LR - 20190107 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 19 IP - 6 DP - 2018 Jun 1 TI - Comparative Study of the Efficacy of 4% Articaine vs 2% Lidocaine in Surgical Removal of Bilaterally Impacted Mandibular Third Molars. PG - 743-748 AB - AIM: The aim of this study was to evaluate the safety and efficacy of 4% articaine with epinephrine (1:200,000) vs 2% lidocaine with epinephrine (1:200,000) during surgical removal of impacted mandibular third molars. MATERIALS AND METHODS: The present study was undertaken in 20 patients belonging to American Society of Anesthesiologists (ASA) class I, of the age group between 18 and 30 years with bilaterally impacted mandibular third molars. Each patient underwent similar surgical procedure. In the first appointment, the patient was randomly selected to receive either 4% articaine or 2% lidocaine (both with epinephrine 1:200,000). Intraoperative and postoperative evaluation was done for both the anesthetic solutions. Following parameters were evaluated: total volume of anesthetic solution used during the surgery, onset of action of the anesthetic agent, duration of anesthesia, duration of postoperative analgesia, incidence, type and severity of adverse reactions, any need to reanesthetize the surgical zone and quality of anesthesia provided by the local anesthetic. Subjective pain evaluation was done with the aid of 100 mm length visual analog scale (VAS) both intraoperatively and postoperatively. RESULTS: In the present study, 4% articaine was found to have a significantly shorter onset of action than 2% lidocaine. Duration of anesthesia and postoperative analgesia of 4% articaine with epinephrine 1:200,000 was found to be significantly (1.44 and 1.28 times respectively) longer than 2% lidocaine with epinephrine 1:200,000. But no significant difference was found in other parameters. CONCLUSION: 4% articaine in comparison with 2% lidocaine (both with epinephrine 1:200,000) provided a shorter onset of action and longer duration of anesthesia. CLINICAL SIGNIFICANCE: No significant difference was recorded in the anesthetic efficacy between the two solutions. FAU - Mittal, Jyoti AU - Mittal J AD - Department of Oral and Maxillofacial Surgery, Shaheed Kartar Singh Sarabha Dental College & Hospital, Ludhiana, Punjab India, Phone: +918437120001, e-mail: jyotisingla07@yahoo.com. FAU - Kaur, Gurpreet AU - Kaur G AD - Department of Dental, Mohandai Oswal Hospital, Ludhiana Punjab, India. FAU - Mann, Harmunish S AU - Mann HS AD - Department of Maxillofacial Surgery, Apex Dental Hospital Ludhiana, Punjab, India. FAU - Narang, Samisha AU - Narang S AD - Department of Pediatric Dentistry, Shaheed Kartar Singh Sarabha Dental College & Hospital, Ludhiana, Punjab, India. FAU - Kamra, Mohit AU - Kamra M AD - Department of Prosthodontics, Bhojia Dental College, Baddi Himachal Pradesh, India. FAU - Kapoor, Shekhar AU - Kapoor S AD - Department of Oral Medicine and Radiology, Christian Dental College, Ludhiana, Punjab, India. FAU - Sindhi, Madhu AU - Sindhi M AD - Department of Oral and Maxillofacial Surgery, Rayat-Bahra Dental College & Hospital, Mohali, Punjab, India. FAU - Kataria, Ramneet AU - Kataria R AD - Department of Oral and Maxillofacial Surgery, Rayat-Bahra Dental College & Hospital, Mohali, Punjab, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20180601 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) RN - D3SQ406G9X (Carticaine) SB - D SB - IM MH - Anesthesia, Dental/*methods MH - *Anesthetics, Local/administration & dosage MH - *Carticaine/administration & dosage MH - Humans MH - *Lidocaine/administration & dosage MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - *Tooth Extraction/methods MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - Articaine OT - Impacted mandibular third molar OT - Inferior alveolar nerve block OT - Lidocaine Mandibular nerve block. EDAT- 2018/07/01 06:00 MHDA- 2019/01/08 06:00 CRDT- 2018/07/01 06:00 PHST- 2018/07/01 06:00 [entrez] PHST- 2018/07/01 06:00 [pubmed] PHST- 2019/01/08 06:00 [medline] AID - 1526-3711-2097 [pii] PST - epublish SO - J Contemp Dent Pract. 2018 Jun 1;19(6):743-748. PMID- 11166979 OWN - NLM STAT- MEDLINE DCOM- 20010531 LR - 20190818 IS - 0304-3959 (Print) IS - 0304-3959 (Linking) VI - 90 IP - 1-2 DP - 2001 Feb 1 TI - Double-blind parallel comparison of multiple doses of ketorolac, ketoprofen and placebo administered orally to patients with postoperative dental pain. PG - 135-41 AB - Ketorolac 10 and 20 mg, ketoprofen 50 mg and placebo were compared in a multiple-dose, double-blind, randomized analgesic study that included 150 patients with pain after impacted third molar removal. Patients evaluated their study medication over a 48 h period. Bivariate and multivariate analysis revealed statistically significant differences between the different medications studied, evaluated by the consumption of rescue medication (50.4-80.4% of the placebo group required rescue versus 17.0-47.6% of the ketoprofen, 5.7-31.9% of the ketorolac 10 mg and 1.8-22.5% of the ketorolac 20 mg groups), the pain relief experienced by the patient (P<0.05), and the overall efficacy of the medication (P<0.05). The efficacy of ketorolac 10 mg did not differ from that of ketorolac 20 mg, and both were more efficacious than ketoprofen 50 mg, which in turn was more efficacious than the placebo. One-third of the placebo group did not require rescue medication. The factors with the greatest influence on the use of rescue medication were the analgesic taken by the patient and the presence or not of postoperative inflammation. FAU - Olmedo, M V AU - Olmedo MV AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Campus de Cartuja, University of Granada, E-18071, Granada, Spain. FAU - Gálvez, R AU - Gálvez R FAU - Vallecillo, M AU - Vallecillo M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 90Y4QC304K (Ketoprofen) RN - YZI5105V0L (Ketorolac) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Chi-Square Distribution MH - Double-Blind Method MH - Female MH - Humans MH - Ketoprofen/*administration & dosage MH - Ketorolac/*administration & dosage MH - Linear Models MH - Logistic Models MH - Male MH - Molar, Third/*surgery MH - Multivariate Analysis MH - Pain Measurement/*drug effects MH - Pain, Postoperative/*drug therapy MH - Placebo Effect MH - Placebos EDAT- 2001/02/13 11:00 MHDA- 2001/06/02 10:01 CRDT- 2001/02/13 11:00 PHST- 2001/02/13 11:00 [pubmed] PHST- 2001/06/02 10:01 [medline] PHST- 2001/02/13 11:00 [entrez] AID - S0304-3959(00)00396-1 [pii] AID - 10.1016/s0304-3959(00)00396-1 [doi] PST - ppublish SO - Pain. 2001 Feb 1;90(1-2):135-41. doi: 10.1016/s0304-3959(00)00396-1. PMID- 22446438 OWN - NLM STAT- MEDLINE DCOM- 20120813 LR - 20181201 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 23 IP - 2 DP - 2012 Mar TI - Effect of partially selective cyclooxygenase-2 inhibitor in the removal of third molars. PG - e108-12 LID - 10.1097/SCS.0b013e318231e1d5 [doi] AB - A randomized, double-blind clinical trial was carried out involving 25 patients scheduled for the removal of symmetrically positioned lower third molars in separate procedures. Either 100 mg of nimesulide or 7.5 mg of meloxicam was administered 1 hour before surgery and every 12 hours after surgery for 2 days. Evaluations were carried out in the preoperative period as well as on the second and seventh days after surgery. Objective and subjective parameters were recorded for comparison purposes. The patients having received nimesulide had less of a need for additional pain medication in the first 48 hours and had lower pain scale values (P < 0.05). There was less trismus in the meloxicam group (P > 0.05). Postoperative swelling was lower in the nimesulide group (P < 0.05). All measurements on the second day were lower in the nimesulide group (P < 0.001), and only one of these parameters was lower on the seventh day in the nimesulide group, distance from the lower edge of the tragus to the lip commissure on the operated side (P = 0.009, P < 0.001) compared with another group. Nimesulide proved effective in controlling pain and swelling after surgical removal of the lower third molars, with few adverse effects. Meloxicam proved effective in diminishing trismus. FAU - Avelar, Rafael Linard AU - Avelar RL AD - Department of Oral and Maxillofacial Surgery, Universidade de Pernambuco, Recife, Brazil. rafael.ctbmf@yahoo.com.br FAU - Primo, Bruno Tochetto AU - Primo BT FAU - Vogt, Beatriz Farias AU - Vogt BF FAU - de Oliveira e Silva, Emanuel Dias AU - de Oliveira e Silva ED FAU - Antunes, Azoubel Antonio AU - Antunes AA FAU - Magalhães, Maria Thereza Carvalho AU - Magalhães MT FAU - Rocha, Auremir AU - Rocha A LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Sulfonamides) RN - 0 (Thiazines) RN - 0 (Thiazoles) RN - V4TKW1454M (nimesulide) RN - VG2QF83CGL (Meloxicam) SB - D MH - Adolescent MH - Adult MH - Aged MH - Cyclooxygenase 2 Inhibitors/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Meloxicam MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Prospective Studies MH - Sulfonamides/*therapeutic use MH - Thiazines/*therapeutic use MH - Thiazoles/*therapeutic use MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control EDAT- 2012/03/27 06:00 MHDA- 2012/08/14 06:00 CRDT- 2012/03/27 06:00 PHST- 2012/03/27 06:00 [entrez] PHST- 2012/03/27 06:00 [pubmed] PHST- 2012/08/14 06:00 [medline] AID - 00001665-201203000-00089 [pii] AID - 10.1097/SCS.0b013e318231e1d5 [doi] PST - ppublish SO - J Craniofac Surg. 2012 Mar;23(2):e108-12. doi: 10.1097/SCS.0b013e318231e1d5. PMID- 28610818 OWN - NLM STAT- MEDLINE DCOM- 20180731 LR - 20181202 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 46 IP - 12 DP - 2017 Dec TI - Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study. PG - 1615-1625 LID - S0901-5027(17)31468-6 [pii] LID - 10.1016/j.ijom.2017.05.007 [doi] AB - This study aimed to evaluate whether pre-emptive analgesia modifies the tissue expression of tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), and whether there is an association with postoperative surgical outcomes. A triple-blind, randomized, placebo-controlled study of patients undergoing mandibular third molar removal was performed. Volunteers were allocated randomly to receive etoricoxib 120 mg, ibuprofen 400 mg, or placebo 1h before surgery. Twenty-four surgical sites per group were required (95% confidence level and 80% statistical power). Pain scores differed significantly between groups (P<0.001). Etoricoxib and ibuprofen reduced pain scores compared to placebo (P<0.05). Pain scores peaked at 4h postoperative in the experimental groups, but at 2h postoperative in the placebo group (P<0.05). A significant reduction in TNF-α concentration from time 0' to time 30' was seen for ibuprofen (P=0.001) and etoricoxib (P=0.016). The ibuprofen group showed a significant reduction in IL-1β levels from time 0' to time 30' (P=0.038). In conclusion, TNF-α and IL-1β levels and the inflammatory events in third molar surgery were inversely associated with the degree of cyclooxygenase 2 selectivity of the non-steroidal anti-inflammatory drugs used pre-emptively. Patients given pre-emptive analgesia showed significant reductions in the clinical parameters pain, trismus, and oedema when compared to the placebo group. CI - Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Albuquerque, A F M AU - Albuquerque AFM AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil; Division of Oral Surgery, School of Dentistry, Fortaleza University (UNIFOR), Ceará, Fortaleza, Brazil. FAU - Fonteles, C S R AU - Fonteles CSR AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil. FAU - do Val, D R AU - do Val DR AD - Renorbio Post-graduate Program, Federal University of Pernambuco, Recife, Pernambuco, Brazil. FAU - Chaves, H V AU - Chaves HV AD - Post-graduate Program in Health Science, Medical School, Federal University of Ceará, Sobral, Ceará, Brazil. FAU - Bezerra, M M AU - Bezerra MM AD - Post-graduate Program in Health Science, Medical School, Federal University of Ceará, Sobral, Ceará, Brazil. FAU - Pereira, K M A AU - Pereira KMA AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil. FAU - de Barros Silva, P G AU - de Barros Silva PG AD - Division of Oral Surgery, School of Dentistry, Fortaleza University (UNIFOR), Ceará, Fortaleza, Brazil. FAU - de Lima, B B AU - de Lima BB AD - Division of Oral Surgery, Walter Cantídio University Hospital, Ceará, Fortaleza, Brazil. FAU - Soares, E C S AU - Soares ECS AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil. FAU - Ribeiro, T R AU - Ribeiro TR AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil. FAU - Costa, F W G AU - Costa FWG AD - Post-graduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Ceará, Fortaleza, Brazil. Electronic address: fwildson@yahoo.com.br. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170610 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Interleukin-1beta) RN - 0 (Placebos) RN - 0 (Pyridines) RN - 0 (Sulfones) RN - 0 (Tumor Necrosis Factor-alpha) RN - WK2XYI10QM (Ibuprofen) RN - WRX4NFY03R (Etoricoxib) SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesia/*methods MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Cross-Over Studies MH - Cyclooxygenase 2 Inhibitors/*therapeutic use MH - Etoricoxib MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Interleukin-1beta/*metabolism MH - Male MH - Molar, Third/*surgery MH - Pain Management/*methods MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Pyridines/*therapeutic use MH - Sulfones/*therapeutic use MH - *Tooth Extraction MH - Treatment Outcome MH - Tumor Necrosis Factor-alpha/*metabolism OTO - NOTNLM OT - IL-1β OT - TNF-α OT - inflammatory events OT - non-steroidal anti-inflammatory drugs OT - third molar EDAT- 2017/06/15 06:00 MHDA- 2018/08/01 06:00 CRDT- 2017/06/15 06:00 PHST- 2016/11/28 00:00 [received] PHST- 2017/03/08 00:00 [revised] PHST- 2017/05/10 00:00 [accepted] PHST- 2017/06/15 06:00 [pubmed] PHST- 2018/08/01 06:00 [medline] PHST- 2017/06/15 06:00 [entrez] AID - S0901-5027(17)31468-6 [pii] AID - 10.1016/j.ijom.2017.05.007 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2017 Dec;46(12):1615-1625. doi: 10.1016/j.ijom.2017.05.007. Epub 2017 Jun 10. PMID- 21514710 OWN - NLM STAT- MEDLINE DCOM- 20111017 LR - 20151119 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 9 DP - 2011 Sep TI - Submucosal dexamethasone injection improves quality of life measures after third molar surgery: a comparative study. PG - 2289-97 LID - 10.1016/j.joms.2011.01.037 [doi] AB - PURPOSE: The purpose of the present study was to compare the effect of submucosal versus intramuscular administration of dexamethasone sodium phosphate on patients' quality of life after surgical removal of impacted lower third molars. PATIENTS AND METHODS: A randomized, non-blind, clinical trial was planned. The sample was composed of patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar with Class II or III and position B or C, according to the Pell and Gregory classification. The patients were randomly distributed into 1 of 3 groups: submucosal dexamethasone, intramuscular dexamethasone, and a control group that received no steroid. A modified translated questionnaire was used to assess the patients' perception regarding different quality of life dimensions. In addition, the objective measurements of facial pain, swelling, and trismus were performed on days 1, 3, and 7 postoperatively. RESULTS: A total of 33 subjects requiring surgical removal of a single impacted mandibular third molar under local anesthesia were included in the present study. Both dexamethasone groups showed a significant reduction in swelling and pain compared with the control group at all intervals (P < .05). Submucosal dexamethasone provided significant improvement in trismus compared with the control group on day 1 postoperatively (P = .026). Both dexamethasone groups showed a highly significant difference in the effect on quality of life and the duration of effect in all subscale scores (P < .01) except for the "speech" and "appearance" subscales. The effect was comparable between the 2 treated groups in all parameters. The effect of the 2 routes of dexamethasone was also comparable for all parameters. CONCLUSIONS: Submucosal injection of dexamethasone 4 mg is an effective therapeutic strategy for improving the quality of life after surgical removal of impacted lower third molars with a comparable effect on postoperative sequelae to intramuscular injection. It offers a simple, safe, painless, noninvasive, and cost effective therapeutic option for moderate and severe cases. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Majid, Omer Waleed AU - Majid OW AD - Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul, Mosul, Nineveh, Iraq. omerw_majid@yahoo.co.uk LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110422 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Glucocorticoids) RN - 7S5I7G3JQL (Dexamethasone) SB - AIM SB - D SB - IM MH - Adult MH - Analysis of Variance MH - Chi-Square Distribution MH - Dexamethasone/*administration & dosage MH - Edema/drug therapy MH - Facial Pain/drug therapy MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections/methods MH - Injections, Intramuscular MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Mouth Mucosa MH - Pain Measurement MH - Pain, Postoperative/drug therapy MH - Prospective Studies MH - *Quality of Life MH - Statistics, Nonparametric MH - Surveys and Questionnaires MH - Tooth Extraction/adverse effects/*psychology MH - Tooth, Impacted/surgery MH - Trismus/drug therapy MH - Young Adult EDAT- 2011/04/26 06:00 MHDA- 2011/10/18 06:00 CRDT- 2011/04/26 06:00 PHST- 2010/06/15 00:00 [received] PHST- 2011/01/08 00:00 [revised] PHST- 2011/01/28 00:00 [accepted] PHST- 2011/04/26 06:00 [entrez] PHST- 2011/04/26 06:00 [pubmed] PHST- 2011/10/18 06:00 [medline] AID - S0278-2391(11)00164-9 [pii] AID - 10.1016/j.joms.2011.01.037 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Sep;69(9):2289-97. doi: 10.1016/j.joms.2011.01.037. Epub 2011 Apr 22. PMID- 28325960 OWN - NLM STAT- MEDLINE DCOM- 20180223 LR - 20201209 IS - 1918-1523 (Electronic) IS - 1203-6765 (Print) IS - 1203-6765 (Linking) VI - 2017 DP - 2017 TI - Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial. PG - 9246352 LID - 10.1155/2017/9246352 [doi] LID - 9246352 AB - Objectives. The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods. The study cohort consisted of 32 Caucasian outpatients, giving a total of 64 bilateral symmetrical impacted mandibles. Patients were randomized in two experimental groups to receive a preoperative oral dose of paracetamol-codeine (analgesic group) or a placebo (placebo group) at the first and second surgeries. Study participants were asked to record pain intensity scores during the operation and the next 2 days, the time of the first request for rescue analgesic, and the total number of postoperative-supplement paracetamol-codeine tablets. Results. The pain intensity score on the first day was significantly lower in the analgesic group than in the placebo group (p < 0.001). The time to using rescue therapy was significantly longer in the analgesic group than in the placebo group (p = 0.004). The number of paracetamol-codeine tablets used postoperatively did not differ between the analgesic and placebo groups (p = 0.104). Conclusions. Preoperative paracetamol-codeine is effective in providing immediate postoperative pain control after third molar surgery and in delaying the initial onset of pain. This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03049878. FAU - Cristalli, Maria Paola AU - Cristalli MP AUID- ORCID: 0000-0001-7583-7030 AD - Department of Biotechnologies and Medical Surgical Sciences, Sapienza University of Rome, Rome, Italy. FAU - La Monaca, Gerardo AU - La Monaca G AD - Department of Sense Organs, Sapienza University of Rome, Rome, Italy. FAU - De Angelis, Chiara AU - De Angelis C AD - Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy. FAU - Pranno, Nicola AU - Pranno N AUID- ORCID: 0000-0003-4095-0900 AD - Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy. FAU - Annibali, Susanna AU - Annibali S AUID- ORCID: 0000-0002-6631-7444 AD - Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy. LA - eng SI - ClinicalTrials.gov/NCT03049878 PT - Journal Article PT - Randomized Controlled Trial DEP - 20170223 TA - Pain Res Manag JT - Pain research & management JID - 9612504 RN - 0 (Analgesics) RN - 0 (Drug Combinations) RN - 0 (acetaminophen, codeine drug combination) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/*administration & dosage MH - Adult MH - Analgesics/*administration & dosage MH - Codeine/*administration & dosage MH - Cohort Studies MH - Double-Blind Method MH - Drug Administration Routes MH - Drug Combinations MH - Female MH - Humans MH - Male MH - Mandibular Osteotomy/*adverse effects MH - Molar, Third/*surgery MH - Nerve Block/methods MH - Pain Measurement MH - Pain, Postoperative/*etiology/*prevention & control MH - Young Adult PMC - PMC5343255 COIS- The authors declare that there is no conflict of interests regarding the publication of this paper. EDAT- 2017/03/23 06:00 MHDA- 2018/02/24 06:00 CRDT- 2017/03/23 06:00 PHST- 2016/11/29 00:00 [received] PHST- 2017/01/11 00:00 [revised] PHST- 2017/01/17 00:00 [accepted] PHST- 2017/03/23 06:00 [entrez] PHST- 2017/03/23 06:00 [pubmed] PHST- 2018/02/24 06:00 [medline] AID - 10.1155/2017/9246352 [doi] PST - ppublish SO - Pain Res Manag. 2017;2017:9246352. doi: 10.1155/2017/9246352. Epub 2017 Feb 23. PMID- 17408924 OWN - NLM STAT- MEDLINE DCOM- 20070719 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 36 IP - 5 DP - 2007 May TI - Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery. PG - 417-22 AB - The goal of this study was to evaluate the efficacy of single- and multi-dose (5-day) clindamycin therapy for the prevention of inflammatory complications in patients undergoing lower third molar surgical extraction with bone removal. Patients who qualified for the prospective, randomized, double-masked, placebo-controlled trial were randomly divided into three groups: (1) single dose of oral clindamycin administered preoperatively (single-dose group); (2) clindamycin administered preoperatively with continued therapy for 5 days (5-day group); and (3) a placebo group. The following parameters were evaluated on the first, second and seventh days postsurgery: trismus, facial swelling, body temperature, lymphadenopathy, alveolar osteitis and subjective pain sensations. There were 86 patients (31 in the single-dose group, 28 in the 5-day group and 27 in the placebo group) enrolled in the study. There were no statistically significant differences in postoperative inflammatory complications in patients during the first and second days postsurgery. A statistically significant variation in body temperature was reported on the seventh day. Analysis of the postoperative analgesic intake did not show statistically significant differences between examined groups. Clindamycin applied in a single preoperative dose of 600 mg with or without subsequent 5-day therapy does not demonstrate efficacy in prophylaxis for postoperative inflammatory complications after third molar surgery. FAU - Kaczmarzyk, T AU - Kaczmarzyk T AD - Department of Oral Surgery, The Medical College of the Jagiellonian University, ul. Montelupich 4, 31-155 Krakow, Poland. tomkaczm@cm-uj.krakow.pl FAU - Wichlinski, J AU - Wichlinski J FAU - Stypulkowska, J AU - Stypulkowska J FAU - Zaleska, M AU - Zaleska M FAU - Panas, M AU - Panas M FAU - Woron, J AU - Woron J LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20070403 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics) RN - 0 (Anti-Bacterial Agents) RN - 0 (Placebos) RN - 3U02EL437C (Clindamycin) SB - D SB - IM MH - Adult MH - Analgesics/therapeutic use MH - Anti-Bacterial Agents/*administration & dosage MH - Antibiotic Prophylaxis MH - Body Temperature/drug effects MH - Clindamycin/*administration & dosage MH - Double-Blind Method MH - Dry Socket/prevention & control MH - Edema/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Lymphadenitis/prevention & control MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Placebos MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - Surgical Wound Infection/*prevention & control MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Trismus/prevention & control EDAT- 2007/04/06 09:00 MHDA- 2007/07/20 09:00 CRDT- 2007/04/06 09:00 PHST- 2006/09/08 00:00 [received] PHST- 2006/11/22 00:00 [revised] PHST- 2006/12/11 00:00 [accepted] PHST- 2007/04/06 09:00 [pubmed] PHST- 2007/07/20 09:00 [medline] PHST- 2007/04/06 09:00 [entrez] AID - S0901-5027(06)00507-8 [pii] AID - 10.1016/j.ijom.2006.12.003 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2007 May;36(5):417-22. doi: 10.1016/j.ijom.2006.12.003. Epub 2007 Apr 3. PMID- 19531419 OWN - NLM STAT- MEDLINE DCOM- 20090706 LR - 20181201 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 67 IP - 7 DP - 2009 Jul TI - Evaluation of antibiotic prophylaxis in reducing postoperative infection after mandibular third molar extraction in young patients. PG - 1467-72 LID - 10.1016/j.joms.2008.12.066 [doi] AB - PURPOSE: This study evaluated the influence of antibiotic prophylaxis on postoperative complications after inferior third molar removal in young patients. PATIENTS AND METHODS: We extracted 59 mandibular third molars from 59 patients with a mean age of 15 years (range, 12-19 years). The patients were included in the study when radiographs at the time of surgery showed that only the crown of the tooth germ was formed. Patients were randomized into 2 groups, the test group and the control group. The test group received 2-g amoxicillin tablets 1 hour before surgery, and the control group received no antibiotic therapy. The test group included 32 patients, 20 of whom were female and 12 were male; the mean age was 15 years. The control group included 27 patients, 12 of whom were female and 15 were male; the mean age was 15 years. Postoperative complications such as pain, swelling, wound infection, and fever were recorded by use of a questionnaire completed by the patient for the week after the extraction. Suture removal and questionnaire evaluation were performed by a surgeon who did not know the preoperative regimen. RESULTS: The mean operating time was 34 minutes in the control group and 31 minutes in the test group. This difference was not significant. In the test group there was a statistically significant reduction of postoperative pain in the 7 days after the extraction, and the patients had a consistent minor consumption of analgesics. Swelling was always present in the control and test groups in the postoperative week, but in the test group it was a minor sequela and was absent in 2 patients. Wound infection was a sequela reported in 4 patients in the control group and in 1 patient in the test group; this difference was statistically significant (P < .01). Fever was present in 2 patients in the control group and in 1 patient in the test group; this difference was not statistically significant. CONCLUSIONS: A statistically significant difference was found between patients receiving preoperative amoxicillin and the control group in the incidence of postoperative pain, fever, and wound infection. Another important finding was the statistically minor consumption of analgesics in the test group in the postoperative week. FAU - Monaco, Giuseppe AU - Monaco G AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Bologna, Bologna, Italy. studioarno@libero.it FAU - Tavernese, Loredana AU - Tavernese L FAU - Agostini, Renato AU - Agostini R FAU - Marchetti, Claudio AU - Marchetti C LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Bacterial Agents) RN - 804826J2HU (Amoxicillin) SB - AIM SB - D SB - IM MH - Adolescent MH - Amoxicillin/therapeutic use MH - Anti-Bacterial Agents/therapeutic use MH - Antibiotic Prophylaxis/*statistics & numerical data MH - Child MH - Endocarditis, Bacterial/*prevention & control MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Prospective Studies MH - Surgical Wound Infection/etiology/*prevention & control MH - Surveys and Questionnaires MH - *Tooth Extraction/adverse effects MH - Young Adult EDAT- 2009/06/18 09:00 MHDA- 2009/07/07 09:00 CRDT- 2009/06/18 09:00 PHST- 2008/07/24 00:00 [received] PHST- 2008/10/13 00:00 [revised] PHST- 2008/12/19 00:00 [accepted] PHST- 2009/06/18 09:00 [entrez] PHST- 2009/06/18 09:00 [pubmed] PHST- 2009/07/07 09:00 [medline] AID - S0278-2391(09)00279-1 [pii] AID - 10.1016/j.joms.2008.12.066 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2009 Jul;67(7):1467-72. doi: 10.1016/j.joms.2008.12.066. PMID- 8645662 OWN - NLM STAT- MEDLINE DCOM- 19960725 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 34 IP - 1 DP - 1996 Feb TI - Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain. PG - 110-4 AB - The object of the study was to assess the comparative efficacy of three single doses (200, 400, 600 mg) of soluble ibuprofen and ibuprofen tablets after third molar surgery in 148 patients and aged 18-40 years. Outcome was measured by overall assessment of pain (AUC360) assessed from serial visual analogue scales, the number of patients taking additional analgesic and by overall assessment of medication evaluated on a five-point categorical scale. Over the 6-hour investigation period all the ibuprofen treatments with the exception of ibuprofen tablets 200 mg resulted in significantly less pain (p < 0.05) than placebo treatment. A large number of patients required additional analgesia during the investigation period, but the time to taking it was significantly earlier in the placebo group. No significant dose response (p > 0.05) was observed for either ibuprofen preparations assessed by the outcome variable of overall pain experience (AUC360) or time to additional analgesia. There was no significant difference in pain scores or time to taking additional analgesics between the respective doses of soluble and tablet formulations of ibuprofen. Both soluble and tablet formulations of ibuprofen provide effective pain control in the early postoperative period after removal of impacted third molars. There is little analgesic advantage in increasing the dose to 600 mg and only minimal benefit from using a soluble formulation of the drug. FAU - Seymour, R A AU - Seymour RA AD - Dental School, Newcastle upon Tyne. FAU - Ward-Booth, P AU - Ward-Booth P FAU - Kelly, P J AU - Kelly PJ LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Solutions) RN - 0 (Tablets) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Chi-Square Distribution MH - Dose-Response Relationship, Drug MH - Facial Pain/drug therapy MH - Female MH - Humans MH - Ibuprofen/*administration & dosage MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Patient Satisfaction MH - Solutions MH - Statistics, Nonparametric MH - Tablets MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery EDAT- 1996/02/01 00:00 MHDA- 1996/02/01 00:01 CRDT- 1996/02/01 00:00 PHST- 1996/02/01 00:00 [pubmed] PHST- 1996/02/01 00:01 [medline] PHST- 1996/02/01 00:00 [entrez] AID - S0266-4356(96)90147-3 [pii] AID - 10.1016/s0266-4356(96)90147-3 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1996 Feb;34(1):110-4. doi: 10.1016/s0266-4356(96)90147-3. PMID- 11759868 OWN - NLM STAT- MEDLINE DCOM- 20020208 LR - 20171116 IS - 0022-3492 (Print) IS - 0022-3492 (Linking) VI - 72 IP - 11 DP - 2001 Nov TI - Immediate implantation in fresh extraction sockets. A controlled clinical and histological study in man. PG - 1560-71 AB - BACKGROUND: Early implantation may preserve the alveolar anatomy, and the placement of a fixture in a fresh extraction socket helps to maintain the bony crest. Although a number of clinical studies exist, no histological reports show the outcome of implantation in fresh extraction sockets without the use of membranes in humans compared to implants placed in mature bone. METHODS: Forty-eight healthy patients, receiving at least 4 fixtures in each of 2 symmetrical quadrants, underwent placement of 1 experimental fixture placed in a fresh extraction socket (TI) and 1 contralateral fixture in mature bone (CI). TI were placed after atraumatical tooth extraction, with a surgical site at the apex of the socket and a tight contact between the fixture and the socket's walls, but without the use of filling materials or membranes. The flap was coronally repositioned to obtain primary wound closure. Immediately after surgical intervention, a standardized periapical radiograph was taken. Second-stage surgery was done after 6 months. Six months after the second surgery, a second standardized periapical radiograph was taken and clinical parameters (bleeding and plaque index) recorded. Marginal bone loss (MBL) from the time of implant placement to the time of fixture removal was calculated by comparing periapical radiographs. TI and CI were then removed by a hollow drill to obtain histological specimens. Non-demineralized sections were stained by acid fuchsin and toluidine blue, and by von Kossa to evaluate the degree of bone mineralization. The percentage of direct implant-bone contact (DBC) was calculated by a computerized microscopic digitizer. RESULTS: No significant differences in the clinical and radiographic parameters were observed between the 2 experimental categories. There was no statistically significant difference between TI and CI for DBC either in the maxilla or in the mandible. No connective or fibrous tissues were present around TI or CI. Bone resorption was not present in any of the histological sections. CONCLUSIONS: The present study shows that when a screw-type dental implant is placed without the use of barrier membranes or other regenerative materials into a fresh extraction socket with a bone-to-implant gap of 2 mm or less, the clinical outcome and degree of osteointegration does not differ from implants placed in healed, mature bone. FAU - Paolantonio, M AU - Paolantonio M AD - Department of Periodontology, University G. D'Annunzio Chieti, School of Dentistry, Italy. FAU - Dolci, M AU - Dolci M FAU - Scarano, A AU - Scarano A FAU - d'Archivio, D AU - d'Archivio D FAU - di Placido, G AU - di Placido G FAU - Tumini, V AU - Tumini V FAU - Piattelli, A AU - Piattelli A LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 RN - 0 (Benzenesulfonates) RN - 0 (Coloring Agents) RN - 0 (Dental Implants) RN - 15XUH0X66N (Tolonium Chloride) RN - 8RA6L21QTM (acid fuchsin) RN - D1JT611TNE (Titanium) SB - D SB - IM MH - Adult MH - Aged MH - Alveolar Bone Loss/classification MH - Benzenesulfonates MH - Calcification, Physiologic MH - Coloring Agents MH - Dental Implantation, Endosseous/*methods MH - Dental Implants MH - Dental Plaque Index MH - Dental Prosthesis Design MH - Female MH - Follow-Up Studies MH - Humans MH - Image Processing, Computer-Assisted MH - Male MH - Middle Aged MH - Osseointegration MH - Osteoblasts/pathology MH - Osteocytes/pathology MH - Periapical Tissue/diagnostic imaging MH - Periodontal Index MH - Radiography MH - Statistics as Topic MH - Statistics, Nonparametric MH - Surgical Flaps MH - Titanium MH - Tolonium Chloride MH - *Tooth Extraction MH - Tooth Socket/diagnostic imaging/pathology/*surgery MH - Treatment Outcome EDAT- 2002/01/05 10:00 MHDA- 2002/02/09 10:01 CRDT- 2002/01/05 10:00 PHST- 2002/01/05 10:00 [pubmed] PHST- 2002/02/09 10:01 [medline] PHST- 2002/01/05 10:00 [entrez] AID - 10.1902/jop.2001.72.11.1560 [doi] PST - ppublish SO - J Periodontol. 2001 Nov;72(11):1560-71. doi: 10.1902/jop.2001.72.11.1560. PMID- 17112703 OWN - NLM STAT- MEDLINE DCOM- 20070313 LR - 20181201 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 36 IP - 1 DP - 2007 Jan TI - Analgesic and anti-inflammatory dose-response relationship of 7.5 and 15 mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study. PG - 26-31 AB - Fifty patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Meloxicam 7.5 or 15 mg was once daily administered in a double-blind, randomized and crossover manner after the surgery for 4 days. Objective and subjective parameters were recorded for comparison of postoperative courses. Patients treated with 7.5mg meloxicam who underwent osteotomy reported higher pain scores at 1.5, 3, 4, 10, 12 and 16 h (P<0.05) and ingested a greater amount of rescue analgesic medication (P<0.05) than those who did not require osteotomy. A higher percentage of patients who underwent osteotomy medicated with 7.5mg meloxicam needed rescue medication as compared to those who did not require osteotomy (P<0.05). There was a similar mouth opening at suture removal compared with preoperative values for both doses (P>0.05). There were no significant differences concerning swelling observed on the 2nd or 7th postoperative days in comparison with baseline (P>0.05) between the two doses. Pain, trismus and swelling after lower third molar removal not requiring osteotomy can be successfully controlled by a dose regimen of 7.5mg meloxicam once daily. For more aggressive extractions 15 mg meloxicam is advisable. FAU - Calvo, A M AU - Calvo AM AD - Bauru School of Dentistry, University of São Paulo, Bauru/SP, Brazil. FAU - Sakai, V T AU - Sakai VT FAU - Giglio, F P M AU - Giglio FP FAU - Modena, K C S AU - Modena KC FAU - Colombini, B L AU - Colombini BL FAU - Benetello, V AU - Benetello V FAU - Sakamoto, F C AU - Sakamoto FC FAU - Freire, T M S AU - Freire TM FAU - Dionísio, T J AU - Dionísio TJ FAU - Lauris, J R P AU - Lauris JR FAU - Trindade, A S Jr AU - Trindade AS Jr FAU - Faria, F A C AU - Faria FA FAU - Santos, C F AU - Santos CF LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20061116 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Thiazines) RN - 0 (Thiazoles) RN - VG2QF83CGL (Meloxicam) SB - D SB - IM MH - Administration, Oral MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Cross-Over Studies MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Meloxicam MH - Molar, Third/*surgery MH - Osteotomy MH - Pain, Postoperative/*prevention & control MH - Range of Motion, Articular MH - Statistics, Nonparametric MH - Thiazines/*administration & dosage MH - Thiazoles/*administration & dosage MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Trismus/prevention & control EDAT- 2006/11/23 09:00 MHDA- 2007/03/14 09:00 CRDT- 2006/11/23 09:00 PHST- 2006/04/18 00:00 [received] PHST- 2006/08/29 00:00 [revised] PHST- 2006/09/14 00:00 [accepted] PHST- 2006/11/23 09:00 [pubmed] PHST- 2007/03/14 09:00 [medline] PHST- 2006/11/23 09:00 [entrez] AID - S0901-5027(06)00377-8 [pii] AID - 10.1016/j.ijom.2006.09.006 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2007 Jan;36(1):26-31. doi: 10.1016/j.ijom.2006.09.006. Epub 2006 Nov 16. PMID- 32913166 OWN - NLM STAT- MEDLINE DCOM- 20201106 LR - 20201106 IS - 1119-3077 (Print) VI - 23 IP - 9 DP - 2020 Sep TI - The effect of kinesio taping with the web strip technique on pain, edema, and trismus after impacted mandibular third molar surgery. PG - 1260-1265 LID - 10.4103/njcp.njcp_23_20 [doi] AB - BACKGOUND: There are many methods used to alleviate edema, trismus, and pain after impacted third molar (3M) removal, one of which is Kinesio Taping (KT). AIMS: This study aimed to evaluate the effectiveness of Kinesio Taping with Web Strip technique on postoperative morbidity after impacted mandibular 3M extraction. METHODS: The study employed a split-mouth and controlled randomized clinical trial design. A total of 60 patients were scheduled for surgical extractions of bilateral lower 3Ms. They were randomly divided into two groups, and KT was applied to one group while the others was determined as a control group without KT application. Tape was applied directly after surgery and maintained for postoperative (post-op) 7 days. Pain intensity was recorded subjectively using a Visual Analogue Scale (VAS). Pain and analgesic usage were recorded on the post-op 1(st), 2(nd), 3(rd), and 7(th) days. Trismus was evaluated before the surgery and on the post-op 2(nd) and 7(th) days. Facial edema was analyzed on the post-op 2(nd) and 7(th) days by VAS and by measuring the lengths of three lines using a flexible plastic tape measure. RESULTS: VAS pain scores were statistically lower in the KT group on the post-op 1(st), 3(rd) and 7(th) days. Total analgesic usage was also significantly lower in the KT group. On the post-op 2(nd) day, measurement of the lengths of three lines showed a statistically less edema in the KT group. Similar results were obtained from the measurement of edema using VAS. Maximum mouth opening was statistically higher in the KT group on the post-op 2(nd) and 7(th) day. CONCLUSION: KT with the web strip technique should be considered more economic and less traumatic than other approaches, as it is free from systemic side effects and is a simple method to carry out to decrease morbidity. FAU - Yurttutan, M E AU - Yurttutan ME AD - Ankara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara, Turkey. FAU - Sancak, K T AU - Sancak KT AD - Ankara Yildirim Beyazit University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 SB - IM MH - Adolescent MH - Adult MH - Athletic Tape/*statistics & numerical data MH - Edema/epidemiology/etiology/rehabilitation MH - Female MH - Humans MH - Male MH - Mandible/*surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Morbidity MH - Oral Surgical Procedures/*adverse effects/methods MH - Pain Measurement MH - Pain, Postoperative/epidemiology/*rehabilitation MH - Postoperative Complications/prevention & control/rehabilitation MH - Postoperative Period MH - Treatment Outcome MH - Trismus/epidemiology/etiology/*rehabilitation MH - Visual Analog Scale MH - Young Adult OTO - NOTNLM OT - Edema OT - impacted third molar OT - kinesiologic tape OT - morbidity OT - pain COIS- None EDAT- 2020/09/12 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/09/11 05:39 PHST- 2020/09/11 05:39 [entrez] PHST- 2020/09/12 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] AID - NigerJClinPract_2020_23_9_1260_294678 [pii] AID - 10.4103/njcp.njcp_23_20 [doi] PST - ppublish SO - Niger J Clin Pract. 2020 Sep;23(9):1260-1265. doi: 10.4103/njcp.njcp_23_20. PMID- 23657486 OWN - NLM STAT- MEDLINE DCOM- 20140117 LR - 20130801 IS - 1807-3107 (Electronic) IS - 1806-8324 (Linking) VI - 27 IP - 3 DP - 2013 May-Jun TI - Comparative analysis of preemptive analgesic effect of dexamethasone and diclofenac following third molar surgery. PG - 266-71 LID - S1806-83242013005001058 [pii] LID - 10.1590/S1806-83242013005000012 [doi] AB - The objective of the study was to compare the analgesic effectiveness of dexamethasone and diclofenac sodium administered preemptively after surgical removal of third molars. Forty-four ASA (American Society of Anesthesiologists) I patients (19 men, 35 women; 16-28 years old) randomly and double-blindly received diclofenac sodium (50 mg) or dexamethasone (8 mg) or placebo 1 h before surgery. Intensity of pain, measured with a visual analog scale (VAS), was the variable studied at different postoperative times (1 h, 2 h, 3 h, 6 h, 8 h, 12 h, 48 h, 4 d and 7 d). The total amount of rescue medication (TARM) ingested (paracetamol) was another variable of the study. The Kruskal-Wallis statistical test was used. A p value of < .05 was adopted to reject the null hypothesis. The dexamethasone group showed lower pain intensity (p < .05) than the diclofenac sodium and placebo groups (p < .05). No difference in TARM was observed among the groups (p < .05). Preemptively administered, dexamethasone was effective in controlling postoperative pain. FAU - Simone, José Leonardo AU - Simone JL AD - Department of Stomatology, Discipline of Integrated Clinical Dentistry, School of Dentistry, Univ de São Paulo, São Paulo, SP, Brazil. jlsimone@usp.br FAU - Jorge, Waldyr Antonio AU - Jorge WA FAU - Horliana, Anna Carolina Ratto Tempestini AU - Horliana AC FAU - Canaval, Talita Girio AU - Canaval TG FAU - Tortamano, Isabel Peixoto AU - Tortamano IP LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130419 PL - Brazil TA - Braz Oral Res JT - Brazilian oral research JID - 101307187 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 144O8QL0L1 (Diclofenac) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage MH - Dexamethasone/*administration & dosage MH - Diclofenac/*administration & dosage MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Statistics, Nonparametric MH - Time Factors MH - Treatment Outcome MH - Young Adult EDAT- 2013/05/10 06:00 MHDA- 2014/01/18 06:00 CRDT- 2013/05/10 06:00 PHST- 2012/09/14 00:00 [received] PHST- 2013/02/04 00:00 [accepted] PHST- 2013/05/10 06:00 [entrez] PHST- 2013/05/10 06:00 [pubmed] PHST- 2014/01/18 06:00 [medline] AID - S1806-83242013005001058 [pii] AID - 10.1590/S1806-83242013005000012 [doi] PST - ppublish SO - Braz Oral Res. 2013 May-Jun;27(3):266-71. doi: 10.1590/S1806-83242013005000012. Epub 2013 Apr 19. PMID- 22421389 OWN - NLM STAT- MEDLINE DCOM- 20121126 LR - 20120611 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 50 IP - 4 DP - 2012 Jun TI - Intraoral external oblique ridge compared with transbuccal lateral cortical plate fixation for the treatment of fractures of the mandibular angle: prospective randomised trial. PG - 344-9 LID - 10.1016/j.bjoms.2011.06.010 [doi] AB - Since the initial description by Michelet et al. and research by Champy et al. the placement of a single, four-hole, monocortical, osteosynthesis plate has been considered an acceptable method of fixation for a fracture of the mandibular angle. We investigated the null hypothesis that there is no difference in the incidence of postoperative removal of an infected plate between miniplates placed on the mandibular external oblique ridge and those placed on the buccal surface of the mandible through a transbuccal approach to treat a fracture of the angle of the mandible. Patients were randomised to having their angle fractures treated with a ridge plate placed intraorally or transbucally. Other variables were investigated including the effect of smoking, drinking alcohol, oral hygiene, and the method of holding the reduction on removal of the plate, occlusal outcome, and degree of preoperative anatomical displacement and postoperative reduction. We also studied the operating time required for the two techniques, the effect of the presence and consequent removal of a wisdom tooth in the line of the fracture, and the effect of delay in taking the patient to theatre for subsequent removal of the plate for infection. Of the 261 angle fractures 34 (13%) plates were removed because of infection, and 6 of these (18%) required a further period of fixation, such as intermaxillary fixation, to treat non-union. The transbuccal plate had a significantly lower postoperative infection rate (6/124, 5%) than the ridge plate (28/137, 20%) (p=0.001). Smoking adversely affected the healing of angle fractures (p=0.000). Displacement of fractures is related to the infection rate (p=0.003), and there are no significant relations between delay in going to theatre or the presence and potential removal of a wisdom tooth in the line of the fracture and infection rate. There was a highly significant difference between the rate of removal of plates placed intraorally on the external oblique ridge, and plates placed transbucally (p=0.000). Transbuccal plates were far less likely to need removal for infection than ridge plates, odds ratio 5.05. CI - Copyright © 2012. Published by Elsevier Ltd. FAU - Laverick, S AU - Laverick S AD - Maxillofacial Unit, Ninewells Hospital, Dundee, United Kingdom. slaverick@nhs.net FAU - Siddappa, P AU - Siddappa P FAU - Wong, H AU - Wong H FAU - Patel, P AU - Patel P FAU - Jones, D C AU - Jones DC LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20120314 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 SB - D SB - IM MH - Alcohol Drinking/adverse effects MH - Bone Plates/*adverse effects MH - Chi-Square Distribution MH - Fracture Fixation, Internal/adverse effects/*instrumentation/*methods MH - Humans MH - Mandibular Fractures/*surgery MH - Molar, Third/surgery MH - Operative Time MH - Prospective Studies MH - Smoking/adverse effects MH - Statistics, Nonparametric MH - Surgical Wound Infection/*etiology MH - Time-to-Treatment MH - Tooth Extraction EDAT- 2012/03/17 06:00 MHDA- 2012/12/10 06:00 CRDT- 2012/03/17 06:00 PHST- 2010/07/08 00:00 [received] PHST- 2011/06/16 00:00 [accepted] PHST- 2012/03/17 06:00 [entrez] PHST- 2012/03/17 06:00 [pubmed] PHST- 2012/12/10 06:00 [medline] AID - S0266-4356(11)00571-7 [pii] AID - 10.1016/j.bjoms.2011.06.010 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2012 Jun;50(4):344-9. doi: 10.1016/j.bjoms.2011.06.010. Epub 2012 Mar 14. PMID- 24652539 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20191210 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 19 IP - 1 DP - 2015 Mar TI - Validation of data on the use of twin mix in minor oral surgery: comparative evaluation of efficacy of twin mix versus 2 % lignocaine with 1:200000 epinephrine based on power analysis and an UV spectrometry study for chemical stability of the mixture. PG - 37-41 LID - 10.1007/s10006-014-0446-5 [doi] AB - INTRODUCTION: There is convincing evidence supporting the addition of dexamethasone to lignocaine and its administration as an intra-space injection to achieve benefit of a single dose steroid after third molar surgery. This study was undertaken to validate the existing data on the use of twin mix in minor oral surgery based on power analysis, statistical sample size estimation and an ultraviolet (UV) spectrometry study for chemical stability of the mixture. MATERIAL AND METHODS: A prospective, randomized, double-blind trial was designed to validate the pilot study on the efficacy of twin mix and 2 % lignocaine with 1:200,000 epinephrine in the surgical removal of impacted mandibular third molars. Clinical parameters of anaesthetic latency, anaesthetic duration, efficacy of twin mix as an anaesthetic and post-operative patient discomfort were assessed. The stability of active ingredients in the solution was assessed using a double beam UV-visible spectrophotometery. RESULTS: The results of the study showed better post-operative outcome with administration of dexamethasone and lignocaine as an intra-space injection in decreasing the post-operative patient discomfort. The anaesthetic efficacy of the twin-mix admixture was found statistically similar to the control solution of 2 % lignocaine with 1:200,000 epinephrine. The λmax recorded for dexamethasone and local anaesthetic individually was obtained with the twin-mix solution, which indicated no change in the active pharmacological compounds. DISCUSSION: Clinical anaesthetic efficacy of twin mix is comparable to 2 % lignocaine with 1:200,000 epinephrine when administered in the pterygomandibular space with the additional advantage of a single prick co-administration of dexamethasone with local anaesthetic, lesser sting of the local anaesthetic injection, shorter anaesthetic latency, prolonged duration of the soft tissue anaesthesia and decrease in post-operative discomfort after the oral surgical procedure. FAU - Bhargava, Darpan AU - Bhargava D AD - Department of Oral and Maxillofacial Surgery, Peoples College of Dental Sciences, Peoples University, Bhanpur, Bhopal, M.P, India, emaildarpan@gmail.com. FAU - Deshpande, Ashwini AU - Deshpande A FAU - Khare, Piush AU - Khare P FAU - Pandey, Sharad P AU - Pandey SP FAU - Thakur, Niharika AU - Thakur N LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Validation Study DEP - 20140321 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Anesthetics, Combined) RN - 7S5I7G3JQL (Dexamethasone) RN - 98PI200987 (Lidocaine) RN - YKH834O4BH (Epinephrine) SB - D SB - IM MH - Adult MH - *Anesthesia, Dental MH - Anesthetics, Combined/*chemistry MH - Dexamethasone/*chemistry MH - Double-Blind Method MH - Epinephrine/*chemistry MH - Female MH - Humans MH - Injections MH - Lidocaine/*chemistry MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/diagnosis MH - Pilot Projects MH - Prospective Studies MH - *Spectrophotometry, Ultraviolet MH - *Tooth Extraction MH - Young Adult EDAT- 2014/03/22 06:00 MHDA- 2016/12/15 06:00 CRDT- 2014/03/22 06:00 PHST- 2013/12/31 00:00 [received] PHST- 2014/03/10 00:00 [accepted] PHST- 2014/03/22 06:00 [entrez] PHST- 2014/03/22 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - 10.1007/s10006-014-0446-5 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2015 Mar;19(1):37-41. doi: 10.1007/s10006-014-0446-5. Epub 2014 Mar 21. PMID- 23866782 OWN - NLM STAT- MEDLINE DCOM- 20131105 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 71 IP - 9 DP - 2013 Sep TI - Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: a single-blind randomized clinical trial. PG - 1484-9 LID - S0278-2391(13)00490-4 [pii] LID - 10.1016/j.joms.2013.05.004 [doi] AB - PURPOSE: To measure the association between the menstrual cycle and the frequency of alveolar osteitis (AO). MATERIALS AND METHODS: In a study with a single-blind design, patients with bilateral impacted third molar teeth underwent randomized surgical extraction: one tooth during the menstrual period and one during the middle of the cycle. The postoperative examiner was unaware of the menstrual cycle status of the patients. The predictor variable was the timing of the menstrual cycle and was grouped as mid-cycle and menstrual period. The outcome variable was AO, which was measured (without knowledge of the menstrual cycle timing) at 2 to 7 days postoperatively. Other study variables included oral contraceptive (OC) use, smoking status, irrigation used during surgery, extraction difficulty, surgeon experience, number of local anesthetic cartridges used, and patient age. Appropriate bi- and multivariate statistics were computed, and the level of statistical significance was set at P < .05. RESULTS: A total of 145 female patients, with a mean age of 24 years, underwent 290 third molar extractions. The overall frequency of AO was 23.45%. The frequency of AO was significantly greater in the middle of the cycle than during the menstrual period inboth the OC users and nonusers (P < .05). Although OC users revealed a significantly greater frequency of AO compared with nonusers (P < .05), no statistically significant differences were found between the 2 groups during the menstrual period (P > .05). CONCLUSIONS: According to the results of the present study, the menstrual cycle could be a determinant risk factor in the frequency of AO. We recommend that elective procedures be performed during the menstrual period in both OC users and nonusers to eliminate the effect of cycle-related hormonal changes on the development of AO. CI - Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Eshghpour, Majid AU - Eshghpour M AD - Dental Research Center, Oral and Maxillofacial Department, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Rezaei, Naser Mohammadzadeh AU - Rezaei NM FAU - Nejat, AmirHossein AU - Nejat A LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130715 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Local) RN - 0 (Contraceptives, Oral) RN - 98PI200987 (Lidocaine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Anesthetics, Local/administration & dosage MH - Clinical Competence MH - Contraceptives, Oral/therapeutic use MH - Dry Socket/*etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Intraoperative Care MH - Lidocaine/administration & dosage MH - Mandible/surgery MH - Menstrual Cycle/*physiology MH - Menstruation/physiology MH - Molar, Third/*surgery MH - Ovulation/physiology MH - Risk Factors MH - Single-Blind Method MH - Therapeutic Irrigation MH - Tooth Extraction/classification MH - Tooth, Impacted/classification/*surgery MH - Young Adult EDAT- 2013/07/23 06:00 MHDA- 2013/11/06 06:00 CRDT- 2013/07/23 06:00 PHST- 2012/12/02 00:00 [received] PHST- 2013/05/01 00:00 [revised] PHST- 2013/05/05 00:00 [accepted] PHST- 2013/07/23 06:00 [entrez] PHST- 2013/07/23 06:00 [pubmed] PHST- 2013/11/06 06:00 [medline] AID - S0278-2391(13)00490-4 [pii] AID - 10.1016/j.joms.2013.05.004 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2013 Sep;71(9):1484-9. doi: 10.1016/j.joms.2013.05.004. Epub 2013 Jul 15. PMID- 15556325 OWN - NLM STAT- MEDLINE DCOM- 20050201 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 33 IP - 8 DP - 2004 Dec TI - Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. PG - 771-6 AB - There is uncertainty regarding the role of preemptive analgesia in preventing postoperative pain. Most previous studies were of parallel design completed under general anesthesia with many confounding inter-patient's variables. The present study evaluated the efficacy of preemptive ketorolac in a crossover design in patients undergoing bilateral mandibular third molar surgery. This was a double blind, randomized, placebo-controlled study where 34 patients had each of their identical impacted mandibular third molars removed under local anesthesia on two occasions. Each patients acted as their own control; one side was pretreated with intravenous ketorolac 30 mg before surgery followed by placebo injection after surgery, and for the other side, the patient was given placebo injection before surgery and post-treated with intravenous ketorolac 30 mg after surgery. The difference in postoperative pain between pretreated and post-treated side in each patient was assessed by four primary end-points: pain intensity as measured by a 100-mm visual analogue scale hourly for 12 h, time to rescue analgesic, postoperative analgesic consumption, and patient's global assessment. Throughout the 12-h investigation period, patients reported significantly lower pain intensity scores in the ketorolac pretreated sides when compared with the post-treated sides (P = 0.003). Patients also reported a significantly longer time to rescue analgesic (8.9 h versus 6.9 h, P = 0.005), lesser postoperative analgesic consumption (P = 0.007) and better global assessment for the ketorolac pretreated sides (P = 0.01). Pretreatment with intravenous ketorolac has a preemptive effect for postoperative third molar surgery and extended the analgesia by approximately 2 h. FAU - Ong, K S AU - Ong KS AD - Department of Oral and Maxillofacial Surgery, National University of Singapore, 238877 Singapore, Republic of Singapore. cliffong@pacific.net.sg FAU - Seymour, R A AU - Seymour RA FAU - Chen, F G AU - Chen FG FAU - Ho, V C L AU - Ho VC LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - 4EVE5946BQ (Ketorolac Tromethamine) SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intravenous MH - Ketorolac Tromethamine/administration & dosage/*therapeutic use MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Patient Satisfaction MH - Placebos MH - *Premedication MH - Time Factors MH - *Tooth Extraction EDAT- 2004/11/24 09:00 MHDA- 2005/02/03 09:00 CRDT- 2004/11/24 09:00 PHST- 2004/01/08 00:00 [accepted] PHST- 2004/11/24 09:00 [pubmed] PHST- 2005/02/03 09:00 [medline] PHST- 2004/11/24 09:00 [entrez] AID - S0901-5027(04)00054-2 [pii] AID - 10.1016/j.ijom.2004.01.020 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2004 Dec;33(8):771-6. doi: 10.1016/j.ijom.2004.01.020. PMID- 24332324 OWN - NLM STAT- MEDLINE DCOM- 20140821 LR - 20131216 IS - 2212-4411 (Electronic) VI - 117 IP - 1 DP - 2014 Jan TI - Efficacy of preemptive lornoxicam on postoperative analgesia after surgical removal of mandibular third molars. PG - 27-31 LID - S2212-4403(13)00468-9 [pii] LID - 10.1016/j.oooo.2013.08.027 [doi] AB - OBJECTIVE: Pain is the most encountered complication following third molar surgery. Although nonsteroidal anti-inflammatory drugs are often used for pain control, the effect of preemptive lornoxicam has not been detailed. We compare the analgesic efficacy of preemptive lornoxicam versus postoperative lornoxicam. STUDY DESIGN: Forty-three participants aged 18 to 33 years who had bilateral, symmetrical third molars were included in this double-blind, randomized, placebo-controlled study. All participants took part in each of the 2 groups for a 1-month interval (crossover design). Group Pre received lornoxicam 8 mg intravenously 25 minutes before surgery and 2 mL serum saline postoperatively. Group Post was given the opposite protocol. Pain was evaluated by visual analog scale in the first 12 hours. RESULTS: We observed statistically significant differences in the reduction of the pain level in group Pre (P < .05). These participants felt less pain in the first 5 postoperative hours and needed fewer analgesics in the first 12 postoperative hours. CONCLUSIONS: Preemptive lornoxicam is effective for postoperative pain control. CI - Copyright © 2014 Elsevier Inc. All rights reserved. FAU - Zor, Zeynep Fatma AU - Zor ZF AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. Electronic address: fatmazor@gazi.edu.tr. FAU - Isik, Berrin AU - Isik B AD - Associate Professor, Anesthesiology and Reanimation Specialist, Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey. FAU - Cetiner, Sedat AU - Cetiner S AD - Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - ER09126G7A (lornoxicam) SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesia/*methods MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Cross-Over Studies MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/drug therapy/*prevention & control MH - Piroxicam/administration & dosage/*analogs & derivatives MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 2013/12/18 06:00 MHDA- 2014/08/22 06:00 CRDT- 2013/12/17 06:00 PHST- 2013/01/01 00:00 [received] PHST- 2013/08/20 00:00 [revised] PHST- 2013/08/28 00:00 [accepted] PHST- 2013/12/17 06:00 [entrez] PHST- 2013/12/18 06:00 [pubmed] PHST- 2014/08/22 06:00 [medline] AID - S2212-4403(13)00468-9 [pii] AID - 10.1016/j.oooo.2013.08.027 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jan;117(1):27-31. doi: 10.1016/j.oooo.2013.08.027. PMID- 15287311 OWN - NLM STAT- MEDLINE DCOM- 20040902 LR - 20131121 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 33 IP - 3 DP - 2004 Apr TI - Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery. PG - 274-8 AB - The objective of this study was to compare the analgesic efficacy of a single-dose of preoperative intravenous tramadol versus ketorolac in preventing pain after third molar surgery. Sixty-four patients undergoing elective third molar surgery were randomly assigned into one of the two groups (32 in each group): Group I received tramadol 50 mg, and Group 2 received ketorolac 30 mg intravenously preoperatively before the surgery. After injection of the study drugs, a standard intravenous sedation technique was administered and the impacted third molars were removed under local anaesthetic. The difference in postoperative pain was assessed by four primary end-points: pain intensity as measured by a 100-mm visual analogue scale hourly for 12 h, median time to rescue analgesic, postoperative acetaminophen consumption, and patient's global assessment. Throughout the 12-h investigation period, patients reported significantly lower pain intensity scores in the ketorolac versus tramadol group (P = 0.05, Mann-Whitney U-test). Patients also reported significantly longer median time to rescue analgesic (9.0 h versus 7.0 h, P = 0.007, log rank test), lesser postoperative acetaminophen consumption (P = 0.02, Mann-Whitney U-test) and better global assessment (P = 0.01, chi2 test) for the ketorolac versus tramadol group. Preoperative intravenous ketorolac 30 mg is more effective than tramadol 50 mg in the prevention of postoperative dental pain. FAU - Ong, K S AU - Ong KS AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore. cliffong@pacific.net.sg FAU - Tan, J M L AU - Tan JM LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - 39J1LGJ30J (Tramadol) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/therapeutic use MH - Analgesics, Opioid/*therapeutic use MH - Anesthetics, Local/administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Chi-Square Distribution MH - Conscious Sedation MH - Female MH - Humans MH - Injections, Intravenous MH - Ketorolac/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - *Premedication MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Tramadol/*therapeutic use EDAT- 2004/08/04 05:00 MHDA- 2004/09/03 05:00 CRDT- 2004/08/04 05:00 PHST- 2004/08/04 05:00 [pubmed] PHST- 2004/09/03 05:00 [medline] PHST- 2004/08/04 05:00 [entrez] AID - S0901-5027(03)90515-7 [pii] AID - 10.1006/ijom.2003.0515 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2004 Apr;33(3):274-8. doi: 10.1006/ijom.2003.0515. PMID- 22432232 OWN - NLM STAT- MEDLINE DCOM- 20120515 LR - 20150917 IS - 0040-4284 (Print) IS - 0040-4284 (Linking) VI - 129 IP - 1 DP - 2012 Jan TI - Straws do not cause dry sockets when third molars are extracted. PG - 25-32 AB - PURPOSE: To provide evidence in contrast to a widely held belief that the dry socket, ie Alveolar Osteitis (AO), is primarily a biological process and not a mechanical disruption or removal of the clot due to suction from utilizing a straw in the postoperative period. PATIENTS AND METHODS: Sixty randomly selected patients had all 4 third molars extracted. One half of the patients were given straws to use with all meals for 2 days after surgery. RESULTS: Two-hundred-twenty teeth were extracted. No dry socket occurred in the maxilla, 17 occurred in the mandible; 8 or 15% who had used a straw and 9 or 15% who did not. CONCLUSION: There is no evidence that there is an increased incidence of dry sockets when using a straw in the first 2 days after third molars have been extracted. FAU - Bloomer, Charles R AU - Bloomer CR AD - oralsurg@oralsurg.net LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Tex Dent J JT - Texas dental journal JID - 2984821R RN - 0 (Analgesics) RN - 0 (Anti-Infective Agents, Local) RN - 0 (Mouthwashes) RN - MOR84MUD8E (chlorhexidine gluconate) RN - R4KO0DY52L (Chlorhexidine) SB - D RPI - J Mich Dent Assoc. 2012 Jul;94(7):46-51. PMID: 22970505 MH - Adolescent MH - Adult MH - Analgesics/therapeutic use MH - Anti-Infective Agents, Local/therapeutic use MH - Chlorhexidine/analogs & derivatives/therapeutic use MH - *Cooking and Eating Utensils MH - *Drinking MH - Dry Socket/*etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/pathology MH - Maxilla/pathology MH - Molar, Third/*surgery MH - Mouthwashes/therapeutic use MH - Pain, Postoperative/drug therapy MH - Smoking MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Young Adult EDAT- 2012/03/22 06:00 MHDA- 2012/05/16 06:00 CRDT- 2012/03/22 06:00 PHST- 2012/03/22 06:00 [entrez] PHST- 2012/03/22 06:00 [pubmed] PHST- 2012/05/16 06:00 [medline] PST - ppublish SO - Tex Dent J. 2012 Jan;129(1):25-32. PMID- 10847536 OWN - NLM STAT- MEDLINE DCOM- 20000928 LR - 20190831 IS - 0303-6979 (Print) IS - 0303-6979 (Linking) VI - 27 IP - 5 DP - 2000 May TI - Healing following GTR treatment of bone defects distal to mandibular 2nd molars after surgical removal of impacted 3rd molars. PG - 325-32 AB - AIM: The purpose of this study was to study the healing, following guided tissue regeneration (GTR) treatment, of bone defects distal to mandibular 2nd molars (M2s) after surgical removal of impacted mesioangularly or horizontally inclined third molars (M3s) in patients > or = 25 years. METHOD: 20 patients with bilateral soft tissue impacted M3s were included in the split-mouth study. The 2 sites to be treated in each patient were randomised before the 1st operation as to which would undergo the test procedure and which would be the control site. After surgical removal of M3 at test sites, a resorbable polylactic acid (PLA) barrier was attached to M2 to cover the post-surgical bone defect. The flap was then replaced and sutured to cover the barrier. Control sites underwent the same procedure, as did the test sites, with the exception that no barrier was placed. The clinical examinations performed were oral hygiene pre- and 12 months postoperatively and probing pocket depth 12 months postoperatively. The alveolar bone level (ABL) at the distal surface of the M2, as determined from radiographs taken at suture removal and 12 months postsurgery, was chosen to be the primary response variable. RESULTS: Most bone defects showed healing up to 10%-20% of the tooth length at both test and control sites. 2 test and 2 control sites showed no improvement in the bone level. The mean values of bone healing registered in mm from the cemento-enamel junction (CEJ) were 2.6 +/- 2.19 SD and 3.0 +/- 2.20 SD for test and control sites, respectively. Different factors affecting the healing result are discussed. FAU - Karapataki, S AU - Karapataki S AD - Department of Periodontology, The Institute for Postgraduate Dental Education, Jönköping, Sweden. FAU - Hugoson, A AU - Hugoson A FAU - Kugelberg, C F AU - Kugelberg CF LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 RN - 0 (Biocompatible Materials) RN - 0 (Citrates) RN - 0 (Guidor) RN - 0 (Membranes, Artificial) RN - 0 (Polyesters) SB - D SB - IM MH - Absorbable Implants MH - Adult MH - Alveolar Bone Loss/diagnostic imaging/etiology/*surgery MH - Biocompatible Materials MH - *Bone Regeneration MH - Citrates MH - Female MH - Guided Tissue Regeneration, Periodontal/*methods MH - Humans MH - Male MH - Mandible MH - *Membranes, Artificial MH - Molar, Third/surgery MH - Polyesters MH - Radiography MH - Root Resorption/etiology MH - Tooth Extraction/adverse effects MH - Treatment Outcome MH - Wound Healing EDAT- 2000/06/10 09:00 MHDA- 2000/09/30 11:01 CRDT- 2000/06/10 09:00 PHST- 2000/06/10 09:00 [pubmed] PHST- 2000/09/30 11:01 [medline] PHST- 2000/06/10 09:00 [entrez] AID - 10.1034/j.1600-051x.2000.027005325.x [doi] PST - ppublish SO - J Clin Periodontol. 2000 May;27(5):325-32. doi: 10.1034/j.1600-051x.2000.027005325.x. PMID- 2234874 OWN - NLM STAT- MEDLINE DCOM- 19901218 LR - 20201209 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 70 IP - 5 DP - 1990 Nov TI - A study of the comparative efficacy of four common analgesics in the control of postsurgical dental pain. PG - 559-63 AB - Four common oral analgesics were tested in a single-blind trial to determine their relative efficacy in the management of postsurgical pain in 103 patients who had their impacted third molars surgically removed under general anesthesia. The analgesics tested were acetylsalicylic acid (26 patients), ibuprofen (26 patients), a paracetamol/codeine/caffeine combination (Solpadeine) (25 patients), and dihydrocodeine (26 patients). The paracetamol/codeine/caffeine combination, ibuprofen, and acetylsalicylic acid preparations produced equally effective analgesia. Dihydrocodeine was found to be a poor analgesic in this pain model. There were no adverse reactions to any of the preparations. FAU - Habib, S AU - Habib S AD - Bristol Dental Hospital and School, England. FAU - Matthews, R W AU - Matthews RW FAU - Scully, C AU - Scully C FAU - Levers, B G AU - Levers BG FAU - Shepherd, J P AU - Shepherd JP LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Analgesics) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - 3G6A5W338E (Caffeine) RN - 82400-20-2 (solpadeine) RN - N9I9HDB855 (dihydrocodeine) RN - R16CO5Y76E (Aspirin) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Analgesics/*therapeutic use MH - Analysis of Variance MH - Aspirin/therapeutic use MH - Caffeine/therapeutic use MH - Codeine/analogs & derivatives/therapeutic use MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/therapeutic use MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Random Allocation MH - Single-Blind Method MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1990/11/01 00:00 MHDA- 1990/11/01 00:01 CRDT- 1990/11/01 00:00 PHST- 1990/11/01 00:00 [pubmed] PHST- 1990/11/01 00:01 [medline] PHST- 1990/11/01 00:00 [entrez] AID - 10.1016/0030-4220(90)90396-a [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1990 Nov;70(5):559-63. doi: 10.1016/0030-4220(90)90396-a. PMID- 11049005 OWN - NLM STAT- MEDLINE DCOM- 20010531 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 56 IP - 6-7 DP - 2000 Sep TI - An investigation into the efficacy of intravenous diclofenac in post-operative dental pain. PG - 447-52 AB - OBJECTIVE: To evaluate the efficacy of single doses of intravenous diclofenac sodium (25, 50 and 75 mg) in patients with post-operative pain after third-molar surgery in a randomised, placebo-controlled study. METHODS: Two hundred and sixty-nine patients (168 females) who required the removal of their impacted third molars participated in the study, which had received prior ethical approval. Surgery was completed under general anaesthesia and, during the early post-operative period, patients received either a single intravenous dose of diclofenac (25, 50 or 75 mg) or matched placebo in random, double-blind order. Pain intensity was assessed on 10-cm visual analogue scales at fixed time points throughout a 4-h investigation period. Other efficacy variables obtained included time until rescue medication and overall assessment at 4, 6, 12 and 24 h after dosing. RESULTS: Throughout the 4-h investigation period, patients treated with diclofenac reported significantly less pain than those treated with placebo (P < 0.001). No differences were observed among the three doses of diclofenac (P = 0.22). Similar results were observed at 6, 12 and 24 h after dosing. Significant differences were also noted between the placebo group and all the diclofenac treatment groups with respect to time until rescue medication (P < 0.001) and the proportion of patients taking such medication. CONCLUSION: Single doses of i.v. diclofenac (25, 50 and 75 mg) provide significant pain relief after third-molar surgery. The efficacy of this preparation does not appear to be dose related. FAU - Seymour, R A AU - Seymour RA AD - Department of Restorative Dentistry, Dental School, Newcastle upon Tyne, UK. r.a.seymour@newcastle.ac.uk FAU - Moore, U AU - Moore U FAU - Hawkesford, J AU - Hawkesford J FAU - Coulthard, P AU - Coulthard P FAU - Jackson-Leech, D AU - Jackson-Leech D FAU - Thomas, D AU - Thomas D FAU - Hill, M AU - Hill M FAU - Combs, M L AU - Combs ML FAU - Renton, T AU - Renton T FAU - McGurk, M AU - McGurk M LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 144O8QL0L1 (Diclofenac) SB - IM MH - Adult MH - Anesthesia MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - *Molar, Third MH - Pain Measurement/drug effects MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction EDAT- 2000/10/26 11:00 MHDA- 2001/06/02 10:01 CRDT- 2000/10/26 11:00 PHST- 2000/10/26 11:00 [pubmed] PHST- 2001/06/02 10:01 [medline] PHST- 2000/10/26 11:00 [entrez] AID - 10.1007/s002280000177 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 2000 Sep;56(6-7):447-52. doi: 10.1007/s002280000177. PMID- 22209180 OWN - NLM STAT- MEDLINE DCOM- 20120720 LR - 20131121 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 41 IP - 2 DP - 2012 Feb TI - Comparative study of the effect of dexamethasone injection and consumption in lower third molar surgery. PG - 244-7 LID - 10.1016/j.ijom.2011.12.011 [doi] AB - The aim of this study was to compare the effect of intramuscular (IM) injection and consumption of 8 mg dexamethasone in patients after lower third molar (LTM) surgery. 20 healthy Thai patients, average age 20 years, with bilateral LTM removal were recruited for this study, a double blinded, paired sample clinical trial. The washout period was 1 month after the first operation. Clinical assessment of facial swelling, pain and maximum mouth opening were measured before and after operation for 7 days. No significant difference was found in facial swelling between IM injection and consumption of 8 mg dexamethasone after LTM surgery (paired t test P>0.05). The visual analogue scale scores for pain assessment showed no significant difference between IM injection and consumption of dexamethasone (paired t test P>0.05). The results conclude that IM injection or consumption of dexamethasone after LTM surgery can be used to control facial swelling, pain and trismus. CI - Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Boonsiriseth, K AU - Boonsiriseth K AD - Mahidol University, Thailand. FAU - Klongnoi, B AU - Klongnoi B FAU - Sirintawat, N AU - Sirintawat N FAU - Saengsirinavin, C AU - Saengsirinavin C FAU - Wongsirichat, N AU - Wongsirichat N LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article DEP - 20111228 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 0 (Placebos) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Anti-Inflammatory Agents/*administration & dosage MH - Dexamethasone/*administration & dosage MH - Double-Blind Method MH - Edema/prevention & control MH - Facial Pain/prevention & control MH - Female MH - Follow-Up Studies MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible/*surgery MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/prevention & control MH - Placebos MH - Postoperative Complications/prevention & control MH - Range of Motion, Articular/physiology MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Young Adult EDAT- 2012/01/03 06:00 MHDA- 2012/07/21 06:00 CRDT- 2012/01/03 06:00 PHST- 2011/05/05 00:00 [received] PHST- 2011/09/19 00:00 [revised] PHST- 2011/12/01 00:00 [accepted] PHST- 2012/01/03 06:00 [entrez] PHST- 2012/01/03 06:00 [pubmed] PHST- 2012/07/21 06:00 [medline] AID - S0901-5027(11)01567-0 [pii] AID - 10.1016/j.ijom.2011.12.011 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2012 Feb;41(2):244-7. doi: 10.1016/j.ijom.2011.12.011. Epub 2011 Dec 28. PMID- 7799116 OWN - NLM STAT- MEDLINE DCOM- 19950126 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 53 IP - 1 DP - 1995 Jan TI - Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars. PG - 2-7; discussion 7-8 AB - PURPOSE: To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling. METHODS: The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study. RESULTS: After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% (P < .001) compared with the placebo group; measurement with a tape measure showed a 58% (P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo. CONCLUSION: The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action. FAU - Schultze-Mosgau, S AU - Schultze-Mosgau S AD - Institute of Clinical Pharmacology of Hannover Medical School, Germany. FAU - Schmelzeisen, R AU - Schmelzeisen R FAU - Frölich, J C AU - Frölich JC FAU - Schmele, H AU - Schmele H LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Drug Combinations) RN - 0 (Placebos) RN - WK2XYI10QM (Ibuprofen) RN - X4W7ZR7023 (Methylprednisolone) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - *Cheek/diagnostic imaging MH - Double-Blind Method MH - Drug Combinations MH - Edema/diagnostic imaging/*prevention & control MH - Female MH - Humans MH - Ibuprofen/administration & dosage/*therapeutic use MH - Male MH - Methylprednisolone/administration & dosage/*therapeutic use MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Ultrasonography EDAT- 1995/01/01 00:00 MHDA- 1995/01/01 00:01 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 1995/01/01 00:01 [medline] PHST- 1995/01/01 00:00 [entrez] AID - 0278-2391(95)90486-7 [pii] AID - 10.1016/0278-2391(95)90486-7 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1995 Jan;53(1):2-7; discussion 7-8. doi: 10.1016/0278-2391(95)90486-7. PMID- 19304046 OWN - NLM STAT- MEDLINE DCOM- 20090421 LR - 20090323 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 67 IP - 4 DP - 2009 Apr TI - Mastication and late mandibular fracture after surgery of impacted third molars associated with no gross pathology. PG - 856-61 LID - 10.1016/j.joms.2008.09.007 [doi] AB - PURPOSE: This study was undertaken with the null hypothesis that in patients, fully denate or with 1 or 2 teeth missing and older than 25 years, mastication does not affect late mandibular fracture after surgical removal of impacted third molars (M3s) associated with no gross pathology. MATERIALS AND METHODS: Five hundred sixty patients, fully dentate or with 1 or 2 teeth missing and older than 25 years who had no gross pathology associated with their impacted lower M3s, were recruited in this study. They were operated on under local anesthesia using a standard technique and randomly assigned into 2 groups for nonroutine (NR group) and routine (R group) postoperative instructions. In the NR group, patients were postoperatively educated in the possibility of mandibular fracture and were given an emphasis on the necessity of limiting mastication to a soft diet for 4 weeks. In the R group, patients were given no such education or emphasis. Patients were followed up for 2 months, and data concerning patients' age and gender; tooth position, angulation, and depth; date and site of surgery; and occurrence of late mandibular fracture were recorded and statistically analyzed. A value of P less than .05 was considered statistically significant. RESULTS: In no patient group was there a late mandibular fracture recorded. All patients completed the follow-up period, and most of the R group patients had normal eating habits 10 to 14 days after surgery. In no patient group was there a statistically significant difference in relation to gender (P = .735), site of surgery (P = .552), class horizontal space available (P = .427), class highest portion of the M3 crown (P = .424), angulations of the teeth (P = .925), and severity of impaction (P = .445). CONCLUSIONS: In patients, fully dentate or with 1 or 2 teeth missing and older than 25 years who have no jawbone atrophy and no systemic problems that may impair bone strength, mastication seems not to affect late mandibular fracture after surgical removal of impacted M3s associated with no gross pathology. The remote possible risk of the late fracture shown in our patients indicates the need for no special precautions. FAU - Al-Belasy, Fouad A AU - Al-Belasy FA AD - Professor of Oral and Maxillofacial Surgery, Dean, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. albelasy@netscape.net FAU - Tozoglu, Sinan AU - Tozoglu S FAU - Ertas, Umit AU - Ertas U LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adult MH - Bruxism/complications MH - Diet MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandibular Fractures/*etiology MH - Mastication/*physiology MH - Middle Aged MH - Molar, Third/*surgery MH - Patient Education as Topic MH - *Postoperative Complications MH - Radiography, Panoramic MH - Sex Factors MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/classification/*surgery EDAT- 2009/03/24 09:00 MHDA- 2009/04/22 09:00 CRDT- 2009/03/24 09:00 PHST- 2008/03/05 00:00 [received] PHST- 2008/08/14 00:00 [revised] PHST- 2008/09/05 00:00 [accepted] PHST- 2009/03/24 09:00 [entrez] PHST- 2009/03/24 09:00 [pubmed] PHST- 2009/04/22 09:00 [medline] AID - S0278-2391(08)01477-8 [pii] AID - 10.1016/j.joms.2008.09.007 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2009 Apr;67(4):856-61. doi: 10.1016/j.joms.2008.09.007. PMID- 28850471 OWN - NLM STAT- MEDLINE DCOM- 20180730 LR - 20181202 IS - 1877-8879 (Electronic) IS - 1877-8860 (Linking) VI - 11 DP - 2016 Apr TI - Peripheral morphine reduces acute pain in inflamed tissue after third molar extraction: A double-blind, randomized, active-controlled clinical trial. PG - 59-64 LID - S1877-8860(15)00133-0 [pii] LID - 10.1016/j.sjpain.2015.11.013 [doi] AB - BACKGROUND: The clinical use of peripheral analgesic effects of opioids has been investigated in numerous controlled clinical trials. The majorities of these have tested the local, intra-articular administration of morphine in knee surgery and have demonstrated marginal postoperative analgesia. OBJECTIVE: We examined direct morphine infiltration of the surgical site in a clinical model of tooth pain under two different conditions. Eighty-eight patients undergoing surgical tooth removal entered into the two prospective, parallel, randomized, double-blind studies. METHODS: Patients undergoing surgical tooth removal received a standard local anaesthetic solution (articaine plus epinephrine) before surgery. Patients were assigned to an injection of peripheral 2mg morphine either into non-inflamed (Trial I) or inflamed (Trial II) submucous tissue before the surgery. Patients who received an intramuscular morphine in the upper arm were concomitantly given 1ml isotonic saline (NaCl) as a submucous injection. Patients who received a submucous injection of morphine peripherally were concomitantly given an intramuscular injection (IM) of 1ml of NaCl in the upper arm. Postoperative pain intensity was assessed by the numeric rating scale every 30min for the first 2h and then every hour for the next 8h after surgery. In addition, patients recorded the occurrence of side effects and the supplemental consumption of ibuprophen and codeine+paracetamol combination tablets. RESULTS: Of the eighty-eight original participants, nine patients (4 patients in Trial I and 5 patients in Trial II) were withdrawn for protocol noncompliance and loss at follow-up. Thirty-one patients in trial I and forty-eight patients in trial II were analyzed. Patients receiving 2mg morphine into non-inflamed tissue did not show any further reduction in pain scores and pain medication consumption compared to IM morphine group (Trial I). In patients receiving 2mg morphine into inflamed tissue, pain scores at rest were reduced to a similar extent in both groups at all measurement times up to 10h in the follow-up (Trial II). At the same time, in the area under the curves pain scores on swallowing between 2 and 6h in the peripheral morphine group (5.2±5.6) were significantly lower than in the IM morphine group (9.3±7.3, p=0.03), demonstrating the marginal analgesic efficacy of additional morphine. Sedation scores were significantly higher in the peripheral morphine group only 1h after surgery in Trial I (p=0.008). The time to first analgesic intake was similar between groups. No serious side effects were reported. CONCLUSIONS: Our results showed in patients undergoing surgical tooth removal that injection of 2mg of morphine into inflamed tissue results in significantly lower pain scores on swallowing in the early postoperative state while administration into non-inflamed tissue is not effective. IMPLICATIONS: Our studies indicate that the peripheral administration of opioids, at the doses and conditions set out for these two studies, produces significant analgesia by a pharmacologically specific mechanism that is active in chronically, but not acutely, inflamed tissue. Thus, consistent with preclinical experimental studies, the requirement of an inflammatory process for the occurrence of the peripheral opioid effects is also found in the clinical setting. CI - Copyright © 2015 Scandinavian Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. FAU - Akural, Ethem AU - Akural E AD - Pain Clinic, Helsinki University Central Hospital, Helsinki, Finland. Electronic address: ethem.akural@fimnet.fi. FAU - Järvimäki, Voitto AU - Järvimäki V AD - Department of Anaesthesiology, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland. FAU - Alaniska, Keijo AU - Alaniska K AD - Department of Oral and Maxillofacial Diseases, Oulu University Hospital, Finland; Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland. FAU - Oikarinen, Kyösti AU - Oikarinen K AD - Department of Oral and Maxillofacial Diseases, Oulu University Hospital, Finland; Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland. FAU - Alahuhta, Seppo AU - Alahuhta S AD - Department of Anaesthesiology, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20151231 PL - Germany TA - Scand J Pain JT - Scandinavian journal of pain JID - 101520867 RN - 0 (Analgesics, Opioid) RN - 76I7G6D29C (Morphine) SB - IM CIN - Scand J Pain. 2016 Apr;11:132-134. PMID: 28850453 MH - Acute Pain MH - Analgesics, Opioid/*therapeutic use MH - Double-Blind Method MH - Humans MH - Molar, Third MH - Morphine/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Prospective Studies MH - Tooth Extraction/*adverse effects OTO - NOTNLM OT - *Morphine OT - *Peripheral opioids OT - *Third molar surgery EDAT- 2016/04/01 00:00 MHDA- 2018/07/31 06:00 CRDT- 2017/08/30 06:00 PHST- 2015/08/09 00:00 [received] PHST- 2015/11/21 00:00 [revised] PHST- 2015/11/27 00:00 [accepted] PHST- 2017/08/30 06:00 [entrez] PHST- 2016/04/01 00:00 [pubmed] PHST- 2018/07/31 06:00 [medline] AID - S1877-8860(15)00133-0 [pii] AID - 10.1016/j.sjpain.2015.11.013 [doi] PST - ppublish SO - Scand J Pain. 2016 Apr;11:59-64. doi: 10.1016/j.sjpain.2015.11.013. Epub 2015 Dec 31. PMID- 31323184 OWN - NLM STAT- MEDLINE DCOM- 20200810 LR - 20200810 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 77 IP - 12 DP - 2019 Dec TI - Photobiomodulation Alleviates Postoperative Discomfort After Mandibular Third Molar Surgery. PG - 2412-2421 LID - S0278-2391(19)30639-1 [pii] LID - 10.1016/j.joms.2019.06.009 [doi] AB - PURPOSE: Surgical removal of mandibular third molars is associated with some degree of postoperative pain, trismus, and facial swelling. The purpose of the study was to evaluate the effect of photobiomodulation in reducing these postoperative side effects after surgical removal of mandibular third molars. MATERIALS AND METHODS: This randomized, double-blinded, split-mouth pilot study was carried out in the Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India, among patients with impacted mandibular third molars. In each patient, 1 side was treated by photobiomodulation and the other side received placebo. Photobiomodulation was performed by intraoral and extraoral application of an 830-nm and 30-mW laser at different time points. Pain, trismus, and facial swelling were evaluated at all time points. The number of analgesics taken also was recorded. The data were analyzed using descriptive, bivariate and multivariate statistics. RESULTS: The study was conducted in 25 patients (56% male patients) with a mean age of 22.16 ± 4.60 years. There were 50 sites divided equally into both groups. The sites treated with photobiomodulation showed a significant reduction in pain and swelling (P < .05) compared with the sites in the placebo group. Moreover, an increase in mouth opening was noted after photobiomodulation compared with that in the placebo group, but this was not statistically significant (P > .05). CONCLUSIONS: The results of this study suggest that photobiomodulation is effective in reducing pain and swelling after mandibular third molar surgery. Hence, it can be used as an alternative and effective modality after surgical removal of mandibular third molars, thereby improving the quality of life of the patients. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Singh, Virendra AU - Singh V AD - Senior Professor and Head of Department, Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India. Electronic address: drvirendrasingh1@gmail.com. FAU - Garg, Ashish AU - Garg A AD - Resident, Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India. FAU - Bhagol, Amrish AU - Bhagol A AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India. FAU - Savarna, S AU - Savarna S AD - Physiotherapist, Department of Physiotherapy, Post Graduate Institute of Medical Sciences, Rohtak, India. FAU - Agarwal, Santosh Kumar AU - Agarwal SK AD - Fellow in Craniomaxillofacial Trauma, Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190624 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Edema MH - Female MH - Humans MH - India MH - Male MH - Mandible MH - *Molar, Third MH - *Pain, Postoperative/therapy MH - *Phototherapy MH - Pilot Projects MH - Quality of Life MH - *Tooth Extraction MH - *Tooth, Impacted/surgery MH - Trismus MH - Young Adult EDAT- 2019/07/20 06:00 MHDA- 2020/08/11 06:00 CRDT- 2019/07/20 06:00 PHST- 2018/11/13 00:00 [received] PHST- 2019/06/17 00:00 [revised] PHST- 2019/06/17 00:00 [accepted] PHST- 2019/07/20 06:00 [pubmed] PHST- 2020/08/11 06:00 [medline] PHST- 2019/07/20 06:00 [entrez] AID - S0278-2391(19)30639-1 [pii] AID - 10.1016/j.joms.2019.06.009 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2019 Dec;77(12):2412-2421. doi: 10.1016/j.joms.2019.06.009. Epub 2019 Jun 24. PMID- 17448840 OWN - NLM STAT- MEDLINE DCOM- 20070524 LR - 20191210 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 65 IP - 5 DP - 2007 May TI - Assessing postoperative discomfort after third molar surgery: a prospective study. PG - 901-17 AB - PURPOSE: The purpose of this study was to identify the risk factors for severe discomfort after mandibular third molar surgery and to assess the validity of the Postoperative Symptom Severity (PoSSe) scale. PATIENTS AND METHODS: In a 2-year prospective study, a total of 255 unilateral impacted mandibular third molar teeth were surgically removed under local anesthesia by 3 surgeons. Standardized surgical and analgesic protocols were followed. At the review appointment, 1 week after surgery, all patients returned a completed follow-up questionnaire (PoSSe scale) and were evaluated clinically for postoperative pain (number of painkillers taken) and trismus (differences in mouth opening). Sixteen predictive variables were evaluated using stepwise logistic regression analysis to identify the risk factors associated with severe discomfort. RESULTS: Severe postoperative discomfort was predicted by these independent variables: gender, tobacco use, ramus relationship/space available, and antibiotic prophylaxis. Oral contraceptive use and operation time were not identified as risk factors. The patients' perceptions of the severity of symptoms (PoSSe scale score) was strongly correlated with clinical assessment of trismus (r = 0.54) and pain (r = 0.42). CONCLUSION: The PoSSe scale resulted in a valid and responsive measure of the severity of symptoms after surgical extraction of lower third molars and reflected the clinical severity of the postoperative discomfort. From a patient's perspective, operative factors had little bearing on the quality of life after removal of mandibular third molars. FAU - Grossi, Giovanni Battista AU - Grossi GB AD - Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy. Giovavanni.Grossi@unimi.it FAU - Maiorana, Carlo AU - Maiorana C FAU - Garramone, Rocco Alberto AU - Garramone RA FAU - Borgonovo, Andrea AU - Borgonovo A FAU - Creminelli, Luca AU - Creminelli L FAU - Santoro, Franco AU - Santoro F LA - eng PT - Evaluation Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Aged MH - Amoxicillin-Potassium Clavulanate Combination/*therapeutic use MH - Antibiotic Prophylaxis/*methods MH - Female MH - Humans MH - Logistic Models MH - Male MH - Mandibular Condyle/anatomy & histology MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/*etiology/prevention & control/psychology MH - Prospective Studies MH - Quality of Life/psychology MH - Reproducibility of Results MH - Risk Factors MH - Severity of Illness Index MH - Sex Factors MH - Single-Blind Method MH - Smoking/adverse effects MH - Surveys and Questionnaires MH - Tooth Extraction/*adverse effects/psychology MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Trismus/etiology/psychology EDAT- 2007/04/24 09:00 MHDA- 2007/05/26 09:00 CRDT- 2007/04/24 09:00 PHST- 2005/07/19 00:00 [received] PHST- 2005/12/09 00:00 [revised] PHST- 2005/12/27 00:00 [accepted] PHST- 2007/04/24 09:00 [pubmed] PHST- 2007/05/26 09:00 [medline] PHST- 2007/04/24 09:00 [entrez] AID - S0278-2391(06)01225-0 [pii] AID - 10.1016/j.joms.2005.12.046 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2007 May;65(5):901-17. doi: 10.1016/j.joms.2005.12.046. PMID- 30782886 OWN - NLM STAT- MEDLINE DCOM- 20200225 LR - 20200309 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 9 IP - 2 DP - 2019 Feb 19 TI - Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). PG - e023715 LID - 10.1136/bmjopen-2018-023715 [doi] LID - e023715 AB - OBJECTIVES: To compare efficacy/safety of oral tramadol 75 mg/dexketoprofen 25 mg (TRAM/DKP) and TRAM 75 mg/paracetamol 650 mg (TRAM/paracetamol) in moderate to severe pain following surgical removal of impacted lower third molar. DESIGN: Multicentre, randomised, double-blind, placebo-controlled, phase IIIb study. PARTICIPANTS: Healthy adult patients scheduled for surgical extraction of at least one fully/partially impacted lower third molar requiring bone manipulation. 654 patients were randomised and 653 were eligible for analysis. INTERVENTIONS: Surgery was performed under local anaesthetic. No sedation was permitted. Patients rated pain intensity (PI) using an 11-Numerical Rating Scale (NRS) (0 no pain; 10 worst pain). Participants experiencing moderate/severe pain (≥4) within 4 hours of surgery were randomised (2:2:1 ratio) to a single oral dose of TRAM/DKP 75/25 mg, TRAM/paracetamol 75/650 mg or placebo. MAIN OUTCOME MEASURES: Efficacy was based patients' electronic diaries. Analgesia and pain were recorded as follows: pain relief (PAR) on a 5-point Verbal Rating Scale (0='no relief', 1='a little (perceptible) relief', 2='some (meaningful) relief', 3='lot of relief', 4='complete relief') at the predefined postdose time points t15 min, t30 min, t1 hour, t1.5 hour, t2 hour, t4 hour, t6 hour and t8 hour and PI on the 11-point NRS at t0 and at the same predefined postdose time points. Onset of analgesia documented using double stopwatch method over a 2-hour period. Primary endpoint was total pain relief over 6 hours (TOTPAR6). Rescue medication was available during the treatment period. RESULTS: TRAM/DKP was superior to TRAM/paracetamol and placebo at the primary endpoint TOTPAR6 (p<0.0001). Mean (SD) TOTPAR6 in the TRAM/DKP group was 13 (6.97), while those in the active control and placebo groups were 9.2 (7.65) and 1.9 (3.89), respectively. Superiority of TRAM/DKP over active comparator and placebo was observed at all secondary endpoints. Incidence of adverse events was comparable between active groups. CONCLUSIONS: TRAM/DKP (75/25 mg) is effective and superior to TRAM/paracetamol (75/650 mg) in relieving moderate to severe acute pain following surgical removal of impacted lower third molar, with a faster onset of action, greater and durable analgesia, together with a favourable safety profile. TRIAL REGISTRATION NUMBER: EudraCT 2015-004152-22 and NCT02777970. CI - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Gay-Escoda, Cosme AU - Gay-Escoda C AD - Department of Oral and Maxillofacial Surgery, Bellvitge Biomedical Research Institute (IDIBELL), School of Dentistry, Hospital Duran i Reynals, Barcelona, Spain. FAU - Hanna, Magdi AU - Hanna M AD - Analgesics & Pain Research (APR) Ltd, Beckenham, UK. FAU - Montero, Antonio AU - Montero A AD - Department of Anaesthesiology Pain Treatment and Critical Care, University Hospital Arnau de Vilanova, Lleida, Spain. FAU - Dietrich, Thomas AU - Dietrich T AD - Department of Oral Surgery, School of Dentistry, University of Birmingham and Birmingham Dental Hospital, Birmingham Community NHS Foundation Trust, Birmingham, UK. FAU - Milleri, Stefano AU - Milleri S AD - University Hospital G.B. Rossi, Verona, Italy. AD - Centro Ricerche Cliniche di Verona S.r.l, Verona, Italy. FAU - Giergiel, Ewa AU - Giergiel E AD - Ars-Dent Spokka Partnerska Fitonowicz Giergiel, Białystok, Poland. FAU - Zoltán, Tóth Bagi AU - Zoltán TB AD - 7MH Dr. Radó György Központi Honvédkórház, Budapest, Hungary. FAU - Varrassi, Giustino AU - Varrassi G AD - University of L'Aquila, L'Aquila, Italy. LA - eng SI - ClinicalTrials.gov/NCT02777970 SI - EudraCT/EudraCT 2015-004152-22 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20190219 TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Analgesics, Non-Narcotic) RN - 023C2WHX2V (Tromethamine) RN - 362O9ITL9D (Acetaminophen) RN - 39J1LGJ30J (Tramadol) RN - 90Y4QC304K (Ketoprofen) RN - N674F7L21E (dexketoprofen trometamol) SB - IM EIN - BMJ Open. 2019 Jun 14;9(6):e023715corr1. PMID: 31201197 MH - Acetaminophen/*administration & dosage MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/*administration & dosage MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Ketoprofen/administration & dosage/*analogs & derivatives MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain Management MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*adverse effects MH - Tramadol/*administration & dosage MH - Tromethamine/*administration & dosage MH - Young Adult PMC - PMC6377526 OTO - NOTNLM OT - *clinical trials OT - *oral medicine OT - *pain management OT - *primary care OT - *public health COIS- Competing interests: MH reports personal fees as a consultant for educational symposia by Menarini Group. CG-E reports personal fees from Menarini Group, outside the submitted work. TD reports grants from Menarini Group, during the conduct of the study; grants and personal fees from Institut Biochimique SA, outside the submitted work. AM, SM, EG, TBZ and GV declare no conflict of interest. We attest that we have obtained appropriate permissions and paid any required fees for use of copyright protected materials. EDAT- 2019/02/21 06:00 MHDA- 2020/02/26 06:00 CRDT- 2019/02/21 06:00 PHST- 2019/02/21 06:00 [entrez] PHST- 2019/02/21 06:00 [pubmed] PHST- 2020/02/26 06:00 [medline] AID - bmjopen-2018-023715 [pii] AID - 10.1136/bmjopen-2018-023715 [doi] PST - epublish SO - BMJ Open. 2019 Feb 19;9(2):e023715. doi: 10.1136/bmjopen-2018-023715. PMID- 8492200 OWN - NLM STAT- MEDLINE DCOM- 19930617 LR - 20201209 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 51 IP - 6 DP - 1993 Jun TI - The effect of an ibuprofen-codeine combination for the treatment of patients with pain after removal of lower third molars. PG - 637-40 AB - A double-blind randomized crossover analgesic trial was carried out on 70 patients undergoing surgical removal of one lower third molar at each visit. The analgesic efficacy of a two-dose regimen of the combination ibuprofen-codeine, 400 to 60 mg, was compared with ibuprofen, 400 mg. Each of the two doses was taken when the patient needed pain relief and the pain intensity was measured on a visual analog scale during the 10-hour period after the first medication. Because of carryover effects between periods 1 and 2, the analysis was carried out only for period 1 according to a parallel group design. Of the 60 patients who were evaluated for analgesic effect, the mean pain reduction of dose 1 was 63% for the 29 patients given ibuprofen-codeine and 50% for the 31 patients given ibuprofen; the mean duration of effect was 7.5 and 6.3 hours, respectively. The difference in pain reduction index (pain reduction X duration of effect) between the two treatments was significant in favor of the combination, whereas the separate variables of pain reduction and duration of effect were not significantly different. The mean pain reduction was 67% after doses 1 and 2 for patients on ibuprofen-codeine and 52% for those on ibuprofen; the mean duration of effect was 9.4 and 9.2 hours, respectively. For doses 1 and 2, the difference in pain reduction index per dose between the two treatments was significant but not the difference for the separate variables, pain reduction, and duration of effect.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Petersen, J K AU - Petersen JK AD - Department of Oral and Maxillofacial Surgery, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark. FAU - Hansson, F AU - Hansson F FAU - Strid, S AU - Strid S LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Drug Combinations) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Codeine/*administration & dosage/adverse effects/therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/*administration & dosage/adverse effects/therapeutic use MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Time Factors MH - *Tooth Extraction EDAT- 1993/06/01 00:00 MHDA- 1993/06/01 00:01 CRDT- 1993/06/01 00:00 PHST- 1993/06/01 00:00 [pubmed] PHST- 1993/06/01 00:01 [medline] PHST- 1993/06/01 00:00 [entrez] AID - S0278239193000916 [pii] AID - 10.1016/s0278-2391(10)80262-9 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1993 Jun;51(6):637-40. doi: 10.1016/s0278-2391(10)80262-9. PMID- 8941780 OWN - NLM STAT- MEDLINE DCOM- 19961216 LR - 20131121 IS - 1355-7610 (Print) IS - 1355-7610 (Linking) VI - 1 IP - 1 DP - 1994 Sep TI - A study to compare ibuprofen effervescent granules with ibuprofen tablets in the treatment of acute dental pain. PG - 5-8 AB - PURPOSE OF STUDY: To compare both the speed of onset and efficacy of the analgesia produced by the effervescent granule formulation with that produced by the conventional-release tablet formulation of ibuprofen in patients suffering acute dental pain and to record the incidence and severity of any adverse events. POPULATION STUDIED: Dental out-patients of either sex and over 16 years of age requiring surgical removal of unilateral or bilateral lower third molar teeth under general anaesthesia as day cases. METHODS: A total of 50 patients received the effervescent granules formulation of ibuprofen 600 mg (Brufen Granules) as study treatment and 50 received the 600 mg tablet formulation in this investigator-blind, parallel-group multiple-dose study. Surgery was performed under general anaesthesia by one or two dental surgeons. Patients received either one sachet of ibuprofen granules or one tablet of ibuprofen at six-hourly intervals for up to 24 hours once post-operative pain became moderate to severe. FINDINGS: Both treatments were shown to be efficacious in treating post-operative dental pain. The granules were found to give significantly better pain relief in the first 30 minutes following the first dose. This may be owing to a more rapid absorption from the granules formulation in these patients and/or a local action of ibuprofen in solution in the mouth. CONCLUSION: The effervescent soluble form of ibuprofen (Brufen Granules) is preferable to the conventional tablet form in managing the immediate dental pain experienced post-operatively by most patients because of its faster onset of action. FAU - Sharma, N K AU - Sharma NK AD - Pinderfields General Hospital, Wakefield. FAU - Kindelan, J D AU - Kindelan JD FAU - Hutchinson, D AU - Hutchinson D FAU - Lancaster, L AU - Lancaster L LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Prim Dent Care JT - Primary dental care : journal of the Faculty of General Dental Practitioners (UK) JID - 9617339 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Dosage Forms) RN - 0 (Tablets) RN - WK2XYI10QM (Ibuprofen) SB - D MH - Acute Disease MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Chi-Square Distribution MH - Dosage Forms MH - Facial Pain/*drug therapy/etiology MH - Female MH - Humans MH - Ibuprofen/*administration & dosage/adverse effects MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Patient Satisfaction MH - Single-Blind Method MH - Tablets MH - Time Factors MH - Tooth Extraction/adverse effects EDAT- 1994/09/01 00:00 MHDA- 1994/09/01 00:01 CRDT- 1994/09/01 00:00 PHST- 1994/09/01 00:00 [pubmed] PHST- 1994/09/01 00:01 [medline] PHST- 1994/09/01 00:00 [entrez] PST - ppublish SO - Prim Dent Care. 1994 Sep;1(1):5-8. PMID- 8664090 OWN - NLM STAT- MEDLINE DCOM- 19960805 LR - 20201209 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 180 IP - 9 DP - 1996 May 11 TI - A double-blind placebo-controlled study to assess the efficacy of a compound analgesic to prevent postoperative pain following oral surgery. PG - 335-8 AB - It has been suggested that small doses of opioid drugs given prior to surgery can reduce postoperative pain. This study was designed to compare the effectiveness of a paracetamol/codeine combination and paracetamol alone in preventing the pain following surgical removal of impacted third molar teeth under general anaesthesia. Analysis of the results showed no statistical differences between treatment groups when compared with placebo. We suggest that the opioids may not be the best drugs available to prevent the moderate to severe pain present following some oral surgery procedures. FAU - Sandhu, S AU - Sandhu S AD - Department of Oral and Maxillofacial Surgery, Turner Dental School, Manchester. FAU - Rood, J P AU - Rood JP LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Drug Combinations) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/*therapeutic use MH - Analgesics, Opioid/administration & dosage/*therapeutic use MH - Anesthesia, General MH - Codeine/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Premedication MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery EDAT- 1996/05/11 00:00 MHDA- 1996/05/11 00:01 CRDT- 1996/05/11 00:00 PHST- 1996/05/11 00:00 [pubmed] PHST- 1996/05/11 00:01 [medline] PHST- 1996/05/11 00:00 [entrez] AID - 10.1038/sj.bdj.4809081 [doi] PST - ppublish SO - Br Dent J. 1996 May 11;180(9):335-8. doi: 10.1038/sj.bdj.4809081. PMID- 27755433 OWN - NLM STAT- MEDLINE DCOM- 20180125 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 28 IP - 2 DP - 2017 Mar TI - Effect of Oral Administration of Bromelain on Postoperative Discomfort After Third Molar Surgery. PG - e191-e197 LID - 10.1097/SCS.0000000000003154 [doi] AB - INTRODUCTION: The purpose of this prospective randomized controlled clinical trial was to evaluate the effect of oral administration of bromelain on discomfort after mandibular third molar surgery. MATERIALS AND METHODS: Eighty-four consecutive patients requiring surgical removal of a single mandibular impacted third molar under local anesthesia were randomly assigned to receiving no drug (control group, Group A), postoperative 40 mg bromelain every 6 hours for 6 days (Group B), preoperative 4 mg dexamethasone sodium phosphate as a submucosal injection (Group C), and preoperative 4 mg dexamethasone sodium phosphate as a submucosal injection plus postoperative 40 mg bromelain every 6 hours for 6 days (Group D). Standardized surgical and analgesic protocols were adopted. Maximum interincisal distance and facial contours were measured at baseline and on postoperative days 2 and 7. Pain was measured objectively by counting the number of analgesic tablets required. Patient perception of the severity of symptoms was assessed with a follow-up questionnaire (PoSSe scale). RESULTS: On postoperative day 2, there was a statistically significant reduction in facial edema in both Groups C and D compared with the control group, but no statistically significant differences were observed between Group B and the control group. At evaluation on postoperative day 7, Group D showed a statistically significant reduction in postoperative swelling compared with the control group. The combined use of bromelain and dexamethasone (Group D) induced a statistically significant reduction in the total number of analgesic tablets taken after surgery compared with the control group. The treatment groups had a limited, nonsignificant effect on trismus when compared with the control group. CONCLUSIONS: Bromelain used singly showed moderate anti-inflammatory efficacy, reducing postoperative swelling, albeit not to any significant extent compared with no drug administration. The combined use of bromelain and dexamethasone sodium phosphate yielded the best results in terms of control of postoperative discomfort. FAU - Ghensi, Paolo AU - Ghensi P AD - *Centre for Integrative Biology, University of Trento, Trento †Department of Biomedical and Neuromotorial Science, University of Bologna, Bologna ‡Department of Oral Surgery, Milan, Italy §Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, Gothenborg, Sweden ||Department of Biomedical Sciences, University of Padova, Padova ¶Department of Implantology, University of Milan, IRCSS Cà Granda, Milan, Italy. FAU - Cucchi, Alessandro AU - Cucchi A FAU - Creminelli, Luca AU - Creminelli L FAU - Tomasi, Cristiano AU - Tomasi C FAU - Zavan, Barbara AU - Zavan B FAU - Maiorana, Carlo AU - Maiorana C LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 2BP70L44PR (dexamethasone 21-phosphate) RN - 7S5I7G3JQL (Dexamethasone) RN - 9001-00-7 (Bromelains) SB - D MH - Administration, Oral MH - Adult MH - Analgesics/therapeutic use MH - Anti-Inflammatory Agents/administration & dosage/*therapeutic use MH - Bromelains/administration & dosage/*therapeutic use MH - Dexamethasone/analogs & derivatives/therapeutic use MH - Drug Therapy, Combination MH - Edema/drug therapy MH - Female MH - Glucocorticoids/therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Postoperative Period MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2016/10/19 06:00 MHDA- 2018/01/26 06:00 CRDT- 2016/10/19 06:00 PHST- 2016/10/19 06:00 [pubmed] PHST- 2018/01/26 06:00 [medline] PHST- 2016/10/19 06:00 [entrez] AID - 10.1097/SCS.0000000000003154 [doi] PST - ppublish SO - J Craniofac Surg. 2017 Mar;28(2):e191-e197. doi: 10.1097/SCS.0000000000003154. PMID- 318741 OWN - NLM STAT- MEDLINE DCOM- 19770226 LR - 20191210 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 43 IP - 1 DP - 1977 Jan TI - The prophylactic use of propylic ester of p-hydrobenzoic acid on alveolitis sicca dolorosa. A preliminary report. PG - 32-7 AB - A double-blind experiment was performed to test the possible prophylactic effect of the antifibrinolytically active propylic ester of p-hydroxybenzoic acid (PEPH) on alveolitis sicca dolorosa (dry socket). Tablets containing PEPH or placebo were inserted at random selection into the alveoli of forty-five consecutive patients, each of whom had had an impacted mandibular third molar removed. The prophylactic effect of PEPH in this study was found to be highly significant as compared to that of placebo, and no patients in the experimental group developed alveolitis sicca dolorosa. FAU - Ritzau, M AU - Ritzau M FAU - Swangsilpa, K AU - Swangsilpa K LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Parabens) RN - 0 (Placebos) RN - Z8IX2SC1OH (propylparaben) SB - D SB - IM MH - Adolescent MH - Adult MH - Clinical Trials as Topic MH - Dry Socket/*prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar/surgery MH - Parabens/*therapeutic use MH - Placebos MH - Tooth, Impacted/surgery EDAT- 1977/01/01 00:00 MHDA- 1977/01/01 00:01 CRDT- 1977/01/01 00:00 PHST- 1977/01/01 00:00 [pubmed] PHST- 1977/01/01 00:01 [medline] PHST- 1977/01/01 00:00 [entrez] AID - 10.1016/0030-4220(77)90346-2 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1977 Jan;43(1):32-7. doi: 10.1016/0030-4220(77)90346-2. PMID- 21144709 OWN - NLM STAT- MEDLINE DCOM- 20110628 LR - 20131121 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 40 IP - 3 DP - 2011 Mar TI - Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction. PG - 292-7 LID - 10.1016/j.ijom.2010.10.026 [doi] AB - In this study, 53 patients received piroxicam, administered orally or sublingually, after undergoing removal of symmetrically positioned lower third molars, during two separate appointments. This study used a randomized, blind, cross-over protocol. Objective and subjective parameters were recorded for comparison of postoperative results for 7 days after surgery. Patients treated with oral or sublingual piroxicam reported low postoperative pain scores. The patients who received piroxicam orally took a similar average amount of analgesic rescue medication compared with patients who received piroxicam sublingually (p>0.05). Patients exhibited similar values for mouth opening measured just before surgery and immediately following suture removal 7 days later (p>0.05), and showed no significant differences between routes of piroxicam administration for swelling control during the second or seventh postoperative days (p>0.05). In summary, pain, trismus and swelling after lower third molar extraction, independent of surgical difficulty, could be controlled by piroxicam 20mg administered orally or sublingually and no significant differences were observed between the route of delivery used in this study. CI - Copyright © 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Trindade, P A K AU - Trindade PA AD - Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil. FAU - Giglio, F P M AU - Giglio FP FAU - Colombini-Ishikiriama, B L AU - Colombini-Ishikiriama BL FAU - Calvo, A M AU - Calvo AM FAU - Modena, K C S AU - Modena KC FAU - Ribeiro, D A AU - Ribeiro DA FAU - Dionísio, T J AU - Dionísio TJ FAU - Brozoski, D T AU - Brozoski DT FAU - Lauris, J R P AU - Lauris JR FAU - Faria, F A C AU - Faria FA FAU - Santos, C F AU - Santos CF LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20101208 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 362O9ITL9D (Acetaminophen) SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Administration, Oral MH - Administration, Sublingual MH - Analgesics, Non-Narcotic/therapeutic use MH - Anti-Inflammatory Agents/administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Cross-Over Studies MH - Edema/drug therapy MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Osteotomy MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*administration & dosage MH - Postoperative Complications/drug therapy MH - Range of Motion, Articular/physiology MH - Single-Blind Method MH - Time Factors MH - *Tooth Extraction MH - Treatment Outcome MH - Trismus/drug therapy MH - Young Adult EDAT- 2010/12/15 06:00 MHDA- 2011/06/29 06:00 CRDT- 2010/12/15 06:00 PHST- 2010/05/26 00:00 [received] PHST- 2010/09/29 00:00 [revised] PHST- 2010/10/29 00:00 [accepted] PHST- 2010/12/15 06:00 [entrez] PHST- 2010/12/15 06:00 [pubmed] PHST- 2011/06/29 06:00 [medline] AID - S0901-5027(10)00474-1 [pii] AID - 10.1016/j.ijom.2010.10.026 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2011 Mar;40(3):292-7. doi: 10.1016/j.ijom.2010.10.026. Epub 2010 Dec 8. PMID- 811573 OWN - NLM STAT- MEDLINE DCOM- 19760301 LR - 20191028 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 4 IP - 5 DP - 1975 Oct TI - The effect of sulfonamides on pain and swelling following removal of ectopic third molars. PG - 184-90 AB - A double-blind, placebo-controlled trial was carried out to study the value of cones containing sulfanilamide and sulfathiazole in the healing of third molar sockets. On the seventh postoperative day, 94 patients were examined regarding pain, swelling and the overall effect of the operation. Trials were run to compare sulfa cones directly with a placebo: in addition, the placebo and sulfa drugs were each compared with the effects of no medication. Pairs were made of the left and right mandibular third molars in the same patient and the results assessed by sequential analysis. It was found that although sulfa cones were better than the placebo, they themselves were no better or worse than leaving the socket alone. FAU - MacGregor, A J AU - MacGregor AJ FAU - Hutchinson, D AU - Hutchinson D LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Placebos) RN - 0 (Sulfanilamides) RN - 0 (Sulfathiazoles) SB - D SB - IM MH - Clinical Trials as Topic MH - Dry Socket MH - Edema/*drug therapy MH - Humans MH - Mandible MH - Molar/*surgery MH - Pain/*drug therapy MH - Placebos MH - Postoperative Complications/*drug therapy MH - Sulfanilamides/*therapeutic use MH - Sulfathiazoles/*therapeutic use MH - Tooth Eruption, Ectopic/*surgery MH - Tooth Extraction EDAT- 1975/10/01 00:00 MHDA- 1975/10/01 00:01 CRDT- 1975/10/01 00:00 PHST- 1975/10/01 00:00 [pubmed] PHST- 1975/10/01 00:01 [medline] PHST- 1975/10/01 00:00 [entrez] AID - 10.1016/s0300-9785(75)80024-x [doi] PST - ppublish SO - Int J Oral Surg. 1975 Oct;4(5):184-90. doi: 10.1016/s0300-9785(75)80024-x. PMID- 16274480 OWN - NLM STAT- MEDLINE DCOM- 20090921 LR - 20181113 IS - 1746-160X (Print) IS - 1746-160X (Electronic) IS - 1746-160X (Linking) VI - 1 DP - 2005 Nov 7 TI - Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery. PG - 11 AB - BACKGROUND: The apparent interactions between the mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDS) and steroids suggest that co-therapy may provide beneficial inflammatory and pain relief in the absence of side effects. The aim of the study was to compare the effect of co-administered dexamethasone and diclofenac potassium (diclofenac K) with diclofenac K alone on the postoperative pain, swelling and trismus after surgical removal of third molars. PATIENTS AND METHODS: A prospective randomized double-blind study was conducted at the Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Nigeria. A total of 100 patients were randomly allocated to two treatment groups of dexamethasone (prophylactic 8 mg and postoperative 4 mg IV) and diclofenac K (50 mg Oral before and after surgery), and diclofenac K alone (as with first group). The overall analgesic efficacy of the drug combinations was assessed postoperatively by determination of pain intensity using a category rating scale. Facial swelling was measured using a tape measure placed from tragus to gonion to tragus, while interincisal mouth-opening of patients was measured using a vernier calibrated caliper pre-operatively and post-operatively. RESULTS: Co-administration of dexamethasone and diclofenac K was significantly superior to diclofenac alone for the relief of pain (P < 0.05), and facial swelling up to post-operative 48 hour (P < 0.05). However, there was no significant difference for trismus relief between the two medication protocols (P > 0.05). CONCLUSION: This study illustrates enhanced effects of co-administered dexamethasone and diclofenac K on short-term post-operative pain and swelling, compared to diclofenac potassium alone in third molar surgery. FAU - Bamgbose, Babatunde Olamide AU - Bamgbose BO AD - Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, P,M,B 12003, Lagos, Nigeria. tuntop@yahoo.com FAU - Akinwande, Jelili Adisa AU - Akinwande JA FAU - Adeyemo, Wasiu Lanre AU - Adeyemo WL FAU - Ladeinde, Akinola Ladipo AU - Ladeinde AL FAU - Arotiba, Godwin Toyin AU - Arotiba GT FAU - Ogunlewe, Mobolanle Olugbemiga AU - Ogunlewe MO LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20051107 TA - Head Face Med JT - Head & face medicine JID - 101245792 RN - 0 (Anti-Inflammatory Agents) RN - 144O8QL0L1 (Diclofenac) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adult MH - Anti-Inflammatory Agents/administration & dosage MH - Dexamethasone/*administration & dosage MH - Diclofenac/*administration & dosage MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Inflammation/*drug therapy/etiology MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy/etiology MH - Prospective Studies MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Trismus/*drug therapy/etiology MH - Young Adult PMC - PMC1291385 EDAT- 2005/11/09 09:00 MHDA- 2005/11/09 09:01 CRDT- 2005/11/09 09:00 PHST- 2005/06/17 00:00 [received] PHST- 2005/11/07 00:00 [accepted] PHST- 2005/11/09 09:00 [pubmed] PHST- 2005/11/09 09:01 [medline] PHST- 2005/11/09 09:00 [entrez] AID - 1746-160X-1-11 [pii] AID - 10.1186/1746-160X-1-11 [doi] PST - epublish SO - Head Face Med. 2005 Nov 7;1:11. doi: 10.1186/1746-160X-1-11. PMID- 15278855 OWN - NLM STAT- MEDLINE DCOM- 20040902 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 62 IP - 8 DP - 2004 Aug TI - Psychologic functioning and needs of indigent patients with facial injury: a prospective controlled study. PG - 925-32 AB - PURPOSE: This study sought to examine 1) temporal changes in psychologic functioning over 12 months and 2) baseline differences in mental health and social service needs between orofacial injury patients and sociodemographically comparable controls undergoing elective oral surgery. MATERIALS AND METHODS: Prospective, case-control study of patients treated at a public hospital in Los Angeles, CA. A total of 336 subjects with mandible fractures and 119 subjects undergoing elective removal of their third molars participated in structured, repeated follow-up assessments (10 days, 6 months, and 12 months after their surgical procedures). Multiple imputation was used to manage incomplete data, and propensity score analysis was used to correct for covariate imbalances between the injury and the control cohort. A series of ANOVAs, chi(2) analyses, and odds ratios was conducted. RESULTS: The injury patients continue to experience significant psychologic distress for up to 12 months following the traumatic event. Orofacial injury patients also tend to report more lifetime and current mental health and social service needs than the sociodemographically similar elective-surgery cohort. CONCLUSION: The management of facial injuries in disadvantaged individuals should integrate case management that addresses psychosocial sequelae and service needs of patients. FAU - Lento, Jennifer AU - Lento J AD - Department of Psychology, University of San Diego, San Diego, CA 92110, USA. jlento@sandiego.edu FAU - Glynn, Shirley AU - Glynn S FAU - Shetty, Vivek AU - Shetty V FAU - Asarnow, Joan AU - Asarnow J FAU - Wang, Jianming AU - Wang J FAU - Belin, Thomas R AU - Belin TR LA - eng GR - P05 DE-10598/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adult MH - Analysis of Variance MH - Case Management MH - Case-Control Studies MH - Chi-Square Distribution MH - Cohort Studies MH - Elective Surgical Procedures/psychology MH - Female MH - Follow-Up Studies MH - Health Services Needs and Demand MH - Humans MH - Los Angeles MH - Male MH - Mandibular Fractures/*psychology/surgery MH - Mental Health MH - Molar, Third/surgery MH - Poverty/*psychology MH - Prospective Studies MH - Social Work MH - Stress, Psychological/psychology MH - Tooth Extraction/psychology EDAT- 2004/07/28 05:00 MHDA- 2004/09/03 05:00 CRDT- 2004/07/28 05:00 PHST- 2004/07/28 05:00 [pubmed] PHST- 2004/09/03 05:00 [medline] PHST- 2004/07/28 05:00 [entrez] AID - S0278239104003933 [pii] AID - 10.1016/j.joms.2004.02.009 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2004 Aug;62(8):925-32. doi: 10.1016/j.joms.2004.02.009. PMID- 15033894 OWN - NLM STAT- MEDLINE DCOM- 20040527 LR - 20180126 IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 92 IP - 5 DP - 2004 May TI - Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry. PG - 675-80 AB - BACKGROUND: Rofecoxib, a selective cyclooxygenase-2 inhibitor, and dexketoprofen trometamol, a single isomer non-steroidal anti-inflammatory drug (NSAID), are available for the treatment of acute pain. Both are claimed to have fewer adverse effects than traditional NSAIDs. We have compared them in a clinical setting. METHODS: We performed a double-blind randomized controlled trial involving 120 patients undergoing surgical removal of a single mandibular third molar at the Edinburgh Dental Institute. Those who developed moderate pain within 4 h of the procedure were allocated to one of three groups: rofecoxib 50 mg (Group RO, n=37); dexketoprofen trometamol 25 mg (Group DE, n=42); or placebo (Group PL, n=41). Participants monitored pain intensity and pain relief for 24 h using visual analogue scales (VAS) and verbal rating scales (VRS). The summed, time-weighted pain relief score to 8 h derived from the VRS (TOTPAR 8) was used as the primary outcome variable. RESULTS: No significant difference was demonstrated between Groups RO and DE using TOTPAR 8 as the primary outcome variable. Both drugs were significantly different compared with placebo. Rescue analgesia during the trial period was required by only 15 out of 37 subjects in Group RO, but 35 out of 42 subjects in Group DE. The median times to use of rescue medication were 150 (Group PL), 398 (Group DE) and 1440 min (Group RO). Both drugs were well tolerated and adverse events reported were mild to moderate in severity. CONCLUSIONS: Rofecoxib and dexketoprofen trometamol are effective treatments for acute pain using a dental pain model and are well tolerated. Rofecoxib has a longer duration of action as a single dose and gave adequate analgesia for over half of that study group; patients in the dexketoprofen trometamol group needed more rescue analgesia. FAU - Jackson, I D AU - Jackson ID AD - Edinburgh Dental Institute, Lauriston Building, Lauriston Place, Edinburgh EH3 9YW, UK. iainandjulia@waitrose.com FAU - Heidemann, B H AU - Heidemann BH FAU - Wilson, J AU - Wilson J FAU - Power, I AU - Power I FAU - Brown, R D AU - Brown RD LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20040319 PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Cyclooxygenase Inhibitors) RN - 0 (Isoenzymes) RN - 0 (Lactones) RN - 0 (Membrane Proteins) RN - 0 (Sulfones) RN - 023C2WHX2V (Tromethamine) RN - 0QTW8Z7MCR (rofecoxib) RN - 90Y4QC304K (Ketoprofen) RN - EC 1.14.99.1 (Cyclooxygenase 2) RN - EC 1.14.99.1 (PTGS2 protein, human) RN - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases) RN - N674F7L21E (dexketoprofen trometamol) SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Cyclooxygenase 2 MH - Cyclooxygenase 2 Inhibitors MH - Cyclooxygenase Inhibitors/therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Isoenzymes/antagonists & inhibitors MH - Ketoprofen/*analogs & derivatives/*therapeutic use MH - Lactones/*therapeutic use MH - Male MH - Membrane Proteins MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Prostaglandin-Endoperoxide Synthases MH - Sulfones MH - *Tooth Extraction MH - Tromethamine/*analogs & derivatives/*therapeutic use EDAT- 2004/03/23 05:00 MHDA- 2004/05/28 05:00 CRDT- 2004/03/23 05:00 PHST- 2004/03/23 05:00 [pubmed] PHST- 2004/05/28 05:00 [medline] PHST- 2004/03/23 05:00 [entrez] AID - S0007-0912(17)36068-3 [pii] AID - 10.1093/bja/aeh131 [doi] PST - ppublish SO - Br J Anaesth. 2004 May;92(5):675-80. doi: 10.1093/bja/aeh131. Epub 2004 Mar 19. PMID- 408287 OWN - NLM STAT- MEDLINE DCOM- 19771020 LR - 20191028 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 6 IP - 3 DP - 1977 Jun TI - Bilateral surgical removal of impacted mandibular third molar teeth as a model for drug evaluation: a test with oxyphenbutazone (Tanderil). PG - 177-89 AB - Twenty-four healthy patients undergoing two separate operations for removal of an impacted third molar from one or the other side of the mandible, were included in a double-blind crossover study. On the two occasions either oxyphenbutazone (Tanderil) or placebo was given for 5 days, commencing on the day before surgery. Plasma analyses confirmed drug intake. A number of objective and subjective assessments were recorded for a paired comparison of the postoperative course, including swelling, trismus, local temperature and pain. On the 1st, 3rd and 5th postoperative days after the oxyphenbutazone-operation, the measured swelling averaged 86, 85 and 83%, respectively, of that after the placebo-operation; the corresponding P-values were less than or equal to 0.11, 0.03 and 0.06. Oxyphenbutazone did not significantly reduce the local hyperpyrexia. It exerted, however, an excellent pain relief, which may have contributed to less trismus and patient preference for the course with this drug. The results obtained with this model in humans showed considerable discrepancies with the analgesic and anti-inflammatory effects ascribed to oxyphenbutazone from results in animal models. Side effects were mild and infrequent, and no unfavorable effects on bleeding or wound healing were noted. Routine use of oxyphenbutazone in oral surgery, however, is not recommended. FAU - Album, B AU - Album B FAU - Olsen, I AU - Olsen I FAU - Lokken, P AU - Lokken P LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - H806S4B3NS (Oxyphenbutazone) SB - D SB - IM MH - Adult MH - Clinical Trials as Topic MH - Drug Evaluation MH - Female MH - Humans MH - Male MH - Molar/*surgery MH - Oxyphenbutazone/*therapeutic use MH - Postoperative Complications/prevention & control MH - Tooth, Impacted/*surgery EDAT- 1977/06/01 00:00 MHDA- 1977/06/01 00:01 CRDT- 1977/06/01 00:00 PHST- 1977/06/01 00:00 [pubmed] PHST- 1977/06/01 00:01 [medline] PHST- 1977/06/01 00:00 [entrez] AID - 10.1016/s0300-9785(77)80051-3 [doi] PST - ppublish SO - Int J Oral Surg. 1977 Jun;6(3):177-89. doi: 10.1016/s0300-9785(77)80051-3. PMID- 17175820 OWN - NLM STAT- MEDLINE DCOM- 20070110 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 53 IP - 3 DP - 2006 Fall TI - Attenuation of C-reactive protein increases after exodontia by tramadol and ibuprofen. PG - 78-82 AB - The anti-inflammatory effects of ibuprofen and tramadol were investigated by measuring C-reactive protein concentrations after removal of an impacted lower third molar. Forty-five American Society of Anesthesiologists Class I patients were randomly categorized into 3 equal groups according to postoperative analgesic medication. The first group received tramadol (100 mg every 8 hours), the second group received ibuprofen (400 mg every 8 hours), and the last group received half doses of both drugs in combination (50 mg tramadol every 8 hours and 200 mg ibuprofen every 8 hours). C-reactive protein was measured before surgery to exclude the presence of any preexisting inflammatory condition that might interfere with the study. C-reactive protein was also determined immediately after surgery and 72 hours postoperatively. At 72 hours, C-reactive protein had increased over postsurgery baseline by 123% in the tramadol group (P < .001), 84% in the ibuprofen group (P < .001), and only 37% in the combined analgesic group (P = .078). These results suggest that tramadol may produce supra-additive anti-inflammatory effects with ibuprofen after third-molar extractions. FAU - El-Sharrawy, Eman A AU - El-Sharrawy EA AD - Department of Oral and Maxillofacial Surgery, Tanta University, Cairo, Egypt. elsharrawy@hotmail.com FAU - El-Hakim, Ibrahim E AU - El-Hakim IE FAU - Sameeh, Elham AU - Sameeh E LA - eng PT - Journal Article PT - Randomized Controlled Trial TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Drug Combinations) RN - 39J1LGJ30J (Tramadol) RN - 9007-41-4 (C-Reactive Protein) RN - WK2XYI10QM (Ibuprofen) SB - D MH - Adult MH - Analgesics, Opioid/*pharmacology/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology/therapeutic use MH - C-Reactive Protein/*analysis/metabolism MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/*pharmacology/therapeutic use MH - Inflammation/metabolism/*prevention & control MH - Male MH - Mandible MH - Molar, Third/surgery MH - Pain, Postoperative/prevention & control MH - Statistics, Nonparametric MH - Tooth Extraction MH - Tramadol/*pharmacology/therapeutic use PMC - PMC1693661 EDAT- 2006/12/21 09:00 MHDA- 2007/01/11 09:00 CRDT- 2006/12/21 09:00 PHST- 2006/12/21 09:00 [pubmed] PHST- 2007/01/11 09:00 [medline] PHST- 2006/12/21 09:00 [entrez] AID - 10.2344/0003-3006(2006)53[78:AOCPIA]2.0.CO;2 [doi] PST - ppublish SO - Anesth Prog. 2006 Fall;53(3):78-82. doi: 10.2344/0003-3006(2006)53[78:AOCPIA]2.0.CO;2. PMID- 7004845 OWN - NLM STAT- MEDLINE DCOM- 19810324 LR - 20131121 IS - 0012-1029 (Print) IS - 0012-1029 (Linking) VI - 35 IP - 5 DP - 1980 May TI - [Antiphlogistic and analgesic effect of diclofenac sodium after maxillofacial interventions in a double-blind trial]. PG - 559-63 AB - Diclofenac sodium (Voltaren) was tested over a period of six months in a double-blind experiment for its antiphlogistic and analgesic effect. A retained or impacted lower third molar was removed from each of the 138 patients studied. The postoperative course was evaluated in terms of the criteria of pain, trismus, swelling, and side effects; and the results were recorded. The swelling was objectified by photographic documentation and planimetric measurements. Our studies indicated that diclofenac sodium can also be recommended for the medicamentous prophylaxis of swelling and pain resulting from dental procedures. FAU - Mayer, M AU - Mayer M FAU - Weiss, P AU - Weiss P LA - ger PT - Clinical Trial PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial TT - Uber die antiphlogistische und analgetische Wirkung von Diclofenac-Na nach kieferchirurgischen Eingriffen im Doppelblindversuch. PL - Germany TA - Dtsch Zahnarztl Z JT - Deutsche zahnarztliche Zeitschrift JID - 2984745R RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Phenylacetates) RN - 0 (Placebos) RN - 144O8QL0L1 (Diclofenac) SB - D SB - IM MH - Adolescent MH - Adult MH - *Anti-Inflammatory Agents, Non-Steroidal MH - Clinical Trials as Topic MH - Diclofenac/*therapeutic use MH - Double-Blind Method MH - Humans MH - Molar MH - Phenylacetates/*therapeutic use MH - Placebos MH - *Postoperative Care MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1980/05/01 00:00 MHDA- 1980/05/01 00:01 CRDT- 1980/05/01 00:00 PHST- 1980/05/01 00:00 [pubmed] PHST- 1980/05/01 00:01 [medline] PHST- 1980/05/01 00:00 [entrez] PST - ppublish SO - Dtsch Zahnarztl Z. 1980 May;35(5):559-63. PMID- 22680300 OWN - NLM STAT- MEDLINE DCOM- 20131111 LR - 20130425 IS - 1943-3670 (Electronic) IS - 0022-3492 (Linking) VI - 84 IP - 5 DP - 2013 May TI - Histologic comparison of healing following tooth extraction with ridge preservation using two different xenograft protocols. PG - 585-94 LID - 10.1902/jop.2012.120219 [doi] AB - BACKGROUND: The objectives of this study are to compare differences in histologic and clinical healing following tooth extraction and ridge preservation using two different xenograft treatment protocols. METHODS: Forty-four patients with a non-molar tooth that required extraction and planned implant placement were randomly allocated into two ridge preservation protocol groups. Protocol 1 used a xenograft material consisting of 90% anorganic bovine bone in combination with 10% porcine collagen fibers combined with a resorbable bilayer membrane composed of non-cross-linked porcine types I and III collagen. Protocol 2 used a xenograft sponge composed of 70% cross-linked type I bovine collagen coated with a layer of non-sintered hydroxyapatite mineral on its surface combined with a resorbable membrane composed of type I porcine collagen cross-linked by natural ribose glycation. Following 21 weeks of healing, clinical measurements were repeated, and a core biopsy was obtained and prepared for histologic evaluation of percentages of vital bone, residual graft, and connective tissue/other (CT/other). RESULTS: Similar percentages of CT/other were detected between protocols, with no significant difference between groups (P = 0.763). A significantly greater percentage of vital bone was detected in specimens in protocol 2 (P <0.001). Protocol 1 presented with a mean of 32.83% ± 14.72% vital bone, 13.44% ± 11.57% residual graft material, and 53.73% ± 6.76% CT/other. Protocol 2 presented with a mean of 47.03% ± 9.09% vital bone, no detectable residual graft material, and 52.97% ± 9.09% CT/other. Clinically, no significant differences in dimensional changes were evident between ridge preservation protocols. CONCLUSION: To the best of our knowledge, this study represents the first randomized controlled trial to evaluate clinical and histologic differences seen when using these two xenograft protocols for ridge preservation. FAU - Cook, Deana Clare AU - Cook DC AD - Department of Periodontics, University of Texas Health Science Center, San Antonio, TX., USA. FAU - Mealey, Brian L AU - Mealey BL LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120609 PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 RN - 0 (Membranes, Artificial) SB - D SB - IM MH - Absorbable Implants MH - Adult MH - Aged MH - Alveolar Bone Loss/etiology/pathology/*prevention & control MH - Alveolar Ridge Augmentation/*methods MH - Animals MH - *Bone Regeneration MH - Bone Transplantation/*methods MH - Cattle MH - Dental Implantation, Endosseous MH - Female MH - Guided Tissue Regeneration, Periodontal/*methods MH - Humans MH - Male MH - Membranes, Artificial MH - Middle Aged MH - Statistics, Nonparametric MH - Swine MH - *Tooth Extraction/adverse effects MH - Tooth Socket/surgery MH - Transplantation, Heterologous/*methods MH - Wound Healing/*physiology MH - Young Adult EDAT- 2012/06/12 06:00 MHDA- 2013/11/12 06:00 CRDT- 2012/06/12 06:00 PHST- 2012/06/12 06:00 [entrez] PHST- 2012/06/12 06:00 [pubmed] PHST- 2013/11/12 06:00 [medline] AID - 10.1902/jop.2012.120219 [doi] PST - ppublish SO - J Periodontol. 2013 May;84(5):585-94. doi: 10.1902/jop.2012.120219. Epub 2012 Jun 9. PMID- 21272053 OWN - NLM STAT- MEDLINE DCOM- 20110914 LR - 20181113 IS - 1365-2125 (Electronic) IS - 0306-5251 (Print) IS - 0306-5251 (Linking) VI - 71 IP - 6 DP - 2011 Jun TI - Modelling of pain intensity and informative dropout in a dental pain model after naproxcinod, naproxen and placebo administration. PG - 899-906 LID - 10.1111/j.1365-2125.2011.03924.x [doi] AB - WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: • Modelling has been used to describe the pain relief and dropout for a few non-steroidal anti-inflammatory drugs. WHAT THIS STUDY ADDS: • This study shows the relationship between dose, plasma concentration, pain intensity and dropout for naproxen and naproxcinod. It also extends previous models by using a visual analogue scale for pain intensity instead of modelling pain relief on a categorical scale, and shows the value of including informative dropout in the simulations for visual predictive checks. AIMS: To describe pain intensity (PI) measured on a visual analogue scale (VAS) and dropout due to request for rescue medication after administration of naproxcinod, naproxen or placebo in 242 patients after wisdom tooth removal. METHODS Non-linear mixed effects modelling was used to describe the plasma concentrations of naproxen, either formed from naproxcinod or from naproxen itself, and their relationship to PI and dropout. Goodness of fit was assessed by simultaneous simulations of PI and dropout. RESULTS: Baseline PI for the typical patient was 52.7 mm. The PI was influenced by placebo effects, using an exponential model, and by naproxen concentrations using a sigmoid E(max) model. Typical maximal placebo effect was a decrease in PI by 20.2%, with an onset rate constant of 0.237 h(-1). EC(50) was 0.135 µmol l(-1). A Weibull time-to-event model was used for the dropout, where the hazard was dependent on the predicted PI and by the PI at baseline. Since the dropout was not at random, it was necessary to include the simulated dropout in visual predictive checks (VPC) of PI. CONCLUSIONS: This model describes the relationship between drug effects, PI and the likelihood of dropout after naproxcinod, naproxen and placebo administration. The model provides an opportunity to describe the effects of other doses or formulations, after dental extraction. VPC created by simultaneous simulations of PI and dropout provides a good way of assessing the goodness of fit when there is informative dropout. CI - © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society. FAU - Björnsson, Marcus A AU - Björnsson MA AD - Clinical Pharmacology & DMPK, AstraZeneca R&D Södertälje, Uppsala, Sweden. marcus.bjornsson@astrazeneca.com FAU - Simonsson, Ulrika S H AU - Simonsson US LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (naproxen-n-butyl nitrate) RN - 57Y76R9ATQ (Naproxen) SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Dose-Response Relationship, Drug MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Naproxen/*analogs & derivatives/*therapeutic use MH - Pain Measurement/methods MH - Pain, Postoperative/*prevention & control MH - *Tooth Extraction MH - Young Adult PMC - PMC3099376 EDAT- 2011/01/29 06:00 MHDA- 2011/09/15 06:00 CRDT- 2011/01/29 06:00 PHST- 2011/01/29 06:00 [entrez] PHST- 2011/01/29 06:00 [pubmed] PHST- 2011/09/15 06:00 [medline] AID - 10.1111/j.1365-2125.2011.03924.x [doi] PST - ppublish SO - Br J Clin Pharmacol. 2011 Jun;71(6):899-906. doi: 10.1111/j.1365-2125.2011.03924.x. PMID- 17229548 OWN - NLM STAT- MEDLINE DCOM- 20070426 LR - 20080530 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 36 IP - 4 DP - 2007 Apr TI - Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg). PG - 321-7 AB - The most common complications after surgical extraction of the third mandibular molar are trismus, oedema or swelling, local pain, dysphagia and infection. The aim of this comparative, double-blind, randomized clinical trial was to evaluate the efficacy of two sustained release amoxicillin/clavulanate regimens in the reduction of infection after third molar extractive surgery. A total of 225 patients were randomized into three equal groups: placebo, prophylaxis with single pre-surgical dose of two tablets amoxicillin/clavulanate 1000/62.5 mg, and pre-emptive post-surgery therapy with two tablets amoxicillin/clavulanate 1000/62.5 mg BID for 5 days. A higher rate of infection (P=0.006) was found among patients receiving placebo (16%) than those receiving single-dose prophylaxis (5.3%) or 5-day pre-emptive therapy (2.7%). A relationship between both the duration (13.8% for long versus 7.4% for medium versus 1.6% for short) and difficulty (12.7% with ostectomy versus 3.5% without ostectomy; P=0.011) of surgical procedure and incidence of subsequent infection was also observed. Both prophylactic and therapeutic regimens versus placebo achieved greater reduction of pain after surgery on day 3 (P=0.001). Logistic regression analysis revealed a risk of infection of 24%, 9% and 4% for ostectomy with placebo, prophylaxis and pre-emptive treatment, respectively, whereas it was 7%, 2% and 1% if ostectomy was not performed. Pre-emptive therapy with the oral sustained release amoxicillin/clavulanate formulation reduced the rate of subsequent infection in patients undergoing ostectomy. Prophylaxis was beneficial in simpler procedures and may be indicated in cases where ostectomy is not performed. FAU - Lacasa, J M AU - Lacasa JM AD - Service of Internal Medicine, Hospital Mútua de Terrassa, University of Barcelona, Barcelona, Spain. FAU - Jiménez, J A AU - Jiménez JA FAU - Ferrás, V AU - Ferrás V FAU - Bossom, M AU - Bossom M FAU - Sóla-Morales, O AU - Sóla-Morales O FAU - García-Rey, C AU - García-Rey C FAU - Aguilar, L AU - Aguilar L FAU - Garau, J AU - Garau J LA - eng PT - Clinical Trial, Phase III PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20070116 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Bacterial Agents) RN - 0 (Delayed-Action Preparations) RN - 0 (Placebos) RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) SB - D SB - IM CIN - Int J Oral Maxillofac Surg. 2008 Feb;37(2):199-200. PMID: 17913462 MH - Adult MH - Aged MH - Amoxicillin-Potassium Clavulanate Combination/*administration & dosage MH - Anti-Bacterial Agents/*administration & dosage MH - *Antibiotic Prophylaxis MH - Case-Control Studies MH - Deglutition Disorders/prevention & control MH - Delayed-Action Preparations MH - Double-Blind Method MH - Edema/prevention & control MH - Female MH - Fever/prevention & control MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Osteotomy MH - Pain, Postoperative/prevention & control MH - Placebos MH - Postoperative Complications/*prevention & control MH - Risk Factors MH - Surgical Wound Infection/prevention & control MH - *Tooth Extraction MH - Treatment Outcome MH - Trismus/prevention & control EDAT- 2007/01/19 09:00 MHDA- 2007/04/27 09:00 CRDT- 2007/01/19 09:00 PHST- 2005/12/05 00:00 [received] PHST- 2006/11/10 00:00 [revised] PHST- 2006/11/19 00:00 [accepted] PHST- 2007/01/19 09:00 [pubmed] PHST- 2007/04/27 09:00 [medline] PHST- 2007/01/19 09:00 [entrez] AID - S0901-5027(06)00499-1 [pii] AID - 10.1016/j.ijom.2006.11.007 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2007 Apr;36(4):321-7. doi: 10.1016/j.ijom.2006.11.007. Epub 2007 Jan 16. PMID- 20030426 OWN - NLM STAT- MEDLINE DCOM- 20100427 LR - 20181113 IS - 1179-1950 (Electronic) IS - 0012-6667 (Linking) VI - 70 IP - 1 DP - 2010 TI - Icatibant. PG - 73-81 LID - 10.2165/11204500-000000000-00000 [doi] AB - Icatibant is a selective antagonist of the bradykinin type 2 receptor. In the randomized, double-blind, multicentre, FAST-1 trial, the difference in the median time to the onset of symptom relief (primary endpoint) did not reach statistical significance between a single dose of subcutaneous icatibant 30 mg and placebo in adults with moderate to very severe acute abdominal or cutaneous episodes of hereditary angioedema. However, icatibant was effective with regard to several other endpoints, providing significantly greater reductions from baseline in symptom severity scores 4 and 12 hours after administration, and eliciting significantly shorter times to both first symptom improvement and overall patient improvement than placebo. In the similarly designed, active comparator-controlled, FAST-2 trial, a single dose of subcutaneous icatibant 30 mg was associated with a significantly shorter median time to onset of symptom relief (primary endpoint) than oral tranexamic acid in adults with acute abdominal or cutaneous episodes of hereditary angioedema, and was also more effective than tranexamic acid in terms of most other endpoints. Across both FAST-1 and -2, the efficacy of subcutaneous icatibant 30 mg in the treatment of laryngeal episodes of hereditary angioedema was generally consistent with that seen for abdominal and cutaneous episodes, with a median time to first symptom improvement of 0.6-1.0 hours. Subcutaneous icatibant was generally well tolerated in adult patients with hereditary angioedema in the FAST trials, with the most common adverse events being injection-site reactions that were generally of mild severity, transient in nature and resolved spontaneously without treatment. FAU - Deeks, Emma D AU - Deeks ED AD - Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz LA - eng PT - Journal Article PL - New Zealand TA - Drugs JT - Drugs JID - 7600076 RN - 0 (Bradykinin B2 Receptor Antagonists) RN - 0 (Bronchodilator Agents) RN - 0 (Calcium Channel Blockers) RN - 0 (Serotonin Receptor Agonists) RN - 7PG89G35Q7 (icatibant) RN - S8TIM42R2W (Bradykinin) SB - IM MH - Adult MH - Angioedemas, Hereditary/*drug therapy MH - Bradykinin/*analogs & derivatives/therapeutic use MH - *Bradykinin B2 Receptor Antagonists MH - Bronchodilator Agents/administration & dosage MH - Calcium Channel Blockers/*administration & dosage MH - Chemistry, Pharmaceutical MH - Clinical Trials as Topic MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Administration Schedule MH - Drug Therapy, Combination MH - Humans MH - Infusions, Intravenous MH - Injections, Intravenous MH - Meta-Analysis as Topic MH - *Pain Measurement MH - Pain, Postoperative/drug therapy MH - Serotonin Receptor Agonists/*administration & dosage MH - Tooth Extraction MH - Treatment Outcome EDAT- 2009/12/25 06:00 MHDA- 2010/04/28 06:00 CRDT- 2009/12/25 06:00 PHST- 2009/12/25 06:00 [entrez] PHST- 2009/12/25 06:00 [pubmed] PHST- 2010/04/28 06:00 [medline] AID - 5 [pii] AID - 10.2165/11204500-000000000-00000 [doi] PST - ppublish SO - Drugs. 2010;70(1):73-81. doi: 10.2165/11204500-000000000-00000. PMID- 3473193 OWN - NLM STAT- MEDLINE DCOM- 19870708 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 45 IP - 6 DP - 1987 Jun TI - A double-blind comparison of nalbuphine and meperidine hydrochloride as intravenous analgesics in combination with diazepam for oral surgery outpatients. PG - 473-6 AB - This study compared the analgesic efficacy, sedative, and amnesic properties, and side effects of nalbuphine versus meperidine as intravenous premedicants in combination with intravenous diazepam for the treatment of outpatients undergoing the removal of impacted third molars with alveolar nerve block anesthesia. Forty patients were evaluated in this double-blind crossover study. Nalbuphine was shown to have analgesic, sedative, and amnesic properties similar to meperidine. Nalbuphine, when compared to meperidine, produced significantly lower intraoperative systolic and diastolic blood pressures. Because of this cardiovascular stability, nalbuphine should be considered over meperidine for use in the cardiovascularly compromised patient undergoing oral surgery. FAU - Scott, R F AU - Scott RF LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Drug Combinations) RN - 0 (Morphinans) RN - 9E338QE28F (Meperidine) RN - L2T84IQI2K (Nalbuphine) RN - Q3JTX2Q7TU (Diazepam) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental MH - Blood Pressure/drug effects MH - Diazepam/*administration & dosage MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Injections, Intravenous MH - Male MH - Mandibular Nerve MH - Meperidine/*administration & dosage/adverse effects MH - Molar, Third/surgery MH - Morphinans/*administration & dosage MH - Nalbuphine/*administration & dosage/adverse effects MH - Nerve Block MH - *Preanesthetic Medication MH - Tooth, Impacted/surgery EDAT- 1987/06/01 00:00 MHDA- 1987/06/01 00:01 CRDT- 1987/06/01 00:00 PHST- 1987/06/01 00:00 [pubmed] PHST- 1987/06/01 00:01 [medline] PHST- 1987/06/01 00:00 [entrez] AID - S0278239187000934 [pii] AID - 10.1016/s0278-2391(87)80004-6 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1987 Jun;45(6):473-6. doi: 10.1016/s0278-2391(87)80004-6. PMID- 15907359 OWN - NLM STAT- MEDLINE DCOM- 20060314 LR - 20131121 IS - 0300-5712 (Print) IS - 0300-5712 (Linking) VI - 34 IP - 1 DP - 2006 Jan TI - Comparison of interfacial characteristics of adhesive bonding to superficial versus deep dentine using SEM and staining techniques. PG - 26-34 AB - OBJECTIVES: A primary reason for premature failure of Class II composite restorations is recurrent decay at the gingival margin. The integrity of the gingival margin depends on the bond formed with dentine. Using scanning electron microscopy (SEM) and histomorphologic technique, the purpose of this study was to characterise the adhesive/dentine (a/d) bond in dentine sections from the dentinoenamel junction (DEJ) and the cementoenamel junction (CEJ) with commercial adhesives of varying hydrophobic/hydrophilic composition. MATERIALS AND METHODS: The occlusal 1/3 of the crown was removed from 20 human third molars, this exposed the surface used for the DEJ sections. The teeth were sectioned occluso-gingivally into equal halves: one-half representing the DEJ; the remaining half was sectioned 4mm deep to the exposed surface (CEJ). Each half was treated with the same adhesive. The teeth were randomly selected for treatment with Single Bond (SB, 3M) or Dentastic UNO (UNO, Pulpdent) using wet bonding technique as per manufacturers' instructions. Thin (3-5mum) sections of native a/d interfaces were cut and stained with Goldner's trichrome for light microscopic (LM) examination. Companion slabs were polished and acid-bleach treated, then analysed with SEM. RESULTS: DEJ sections: SB/dentine specimens had approximately 4mum exposed protein at the interface, UNO infiltrated the depth of the demineralised dentine and encapsulated exposed protein. CEJ sections: SB/dentine specimens had highly variable interface structure with localized exposed protein, UNO/dentine exhibited 3-5mum exposed protein at the interface. The quality of the interface was exaggerated and the above differences were not revealed based on SEM characterisation. CONCLUSIONS: As a result of adhesive phase separation, SB does not form structurally integrated a/d bonds at the DEJ or CEJ. The increased hydrophilic composition of UNO contributes to the formation of an integrated a/d bond at the DEJ, but structural differences and increased moisture leads to unprotected protein at the a/d interface in the CEJ sections. The inability of the SEM technique to reveal the complexity of the interface could be related to the modifications of the a/d interface caused by polishing and acid-bleach treatment. FAU - Wang, Yong AU - Wang Y AD - Department of Oral Biology, School of Dentistry, University of Missouri-Kansas City 650 E. 25th St., Kansas City, MO 64108, USA. wangyo@umkc.edu FAU - Spencer, Paulette AU - Spencer P FAU - Hager, Christy AU - Hager C FAU - Bohaty, Brenda AU - Bohaty B LA - eng GR - DE 015281/DE/NIDCR NIH HHS/United States GR - DE/HD00468/DE/NIDCR NIH HHS/United States GR - DE014392/DE/NIDCR NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PL - England TA - J Dent JT - Journal of dentistry JID - 0354422 RN - 0 (Adhesives) RN - 0 (Dentastic) RN - 0 (Dentin-Bonding Agents) RN - 0 (Methacrylates) RN - 0 (single bond) RN - 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate) SB - D SB - IM MH - Adhesives/chemistry MH - Bisphenol A-Glycidyl Methacrylate/chemistry MH - Dental Bonding/*methods MH - Dentin/*ultrastructure MH - Dentin-Bonding Agents/*chemistry MH - Humans MH - Methacrylates/chemistry MH - Microscopy, Electron, Scanning MH - Molar, Third/ultrastructure MH - Tooth Cervix/*ultrastructure EDAT- 2005/05/24 09:00 MHDA- 2006/03/15 09:00 CRDT- 2005/05/24 09:00 PHST- 2004/08/06 00:00 [received] PHST- 2005/02/28 00:00 [revised] PHST- 2005/03/02 00:00 [accepted] PHST- 2005/05/24 09:00 [pubmed] PHST- 2006/03/15 09:00 [medline] PHST- 2005/05/24 09:00 [entrez] AID - S0300-5712(05)00072-2 [pii] AID - 10.1016/j.jdent.2005.03.004 [doi] PST - ppublish SO - J Dent. 2006 Jan;34(1):26-34. doi: 10.1016/j.jdent.2005.03.004. PMID- 11799734 OWN - NLM STAT- MEDLINE DCOM- 20020208 LR - 20131121 IS - 0250-4693 (Print) IS - 0250-4693 (Linking) VI - 42 IP - 1 DP - 2000 Jan-Apr TI - Alterations in monitored vital constants induced by various local anesthetics in combination with different vasoconstrictors in the surgical removal of lower third molars. PG - 1-10 AB - The purpose of this study was to observe the hemodynamic changes during surgical extraction of lower third molars induced by three local anesthetics solutions associated with different vasoconstrictors. A double-blind observational and longitudinal study was made of 45 healthy adult volunteers subjected to surgical removal of an impacted lower third molar under local anesthesia. Three groups were established (n = 15) according to the anesthetic solution and associated vasoconstrictor administered (4% articaine + epinephrine 1:200,000; 3% mepivacaine without vasoconstrictor; and 3% prilocaine + felypressin 1:1,850,000). Heart rate, systolic and diastolic pressure, and oxygen saturation were recorded at different times before, during and at the end of surgery, along with the type and amount of anesthetic solution administered. The study variables were found to be more stable with articaine + epinephrine 1:200,000, although the three studied solutions caused no significant hemodynamic changes with respect to the basal values when administered in healthy patients subjected to surgical removal of a lower third molar. FAU - Carrera, I AU - Carrera I AD - Faculty of Dentistry, University of Barcelona, Barcelona, Spain. FAU - Mestre, R AU - Mestre R FAU - Berini, L AU - Berini L FAU - Gay-Escoda, C AU - Gay-Escoda C LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Belgium TA - Bull Group Int Rech Sci Stomatol Odontol JT - Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie JID - 7801698 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - 046O35D44R (Prilocaine) RN - 56-59-7 (Felypressin) RN - B6E06QE59J (Mepivacaine) RN - D3SQ406G9X (Carticaine) RN - S88TT14065 (Oxygen) RN - YKH834O4BH (Epinephrine) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental MH - Anesthetics, Local/*administration & dosage MH - Blood Pressure/*drug effects MH - Carticaine/administration & dosage MH - Double-Blind Method MH - Epinephrine/administration & dosage MH - Felypressin/administration & dosage MH - Female MH - Follow-Up Studies MH - Heart Rate/*drug effects MH - Humans MH - Longitudinal Studies MH - Male MH - Mandible MH - Mepivacaine/administration & dosage MH - Middle Aged MH - Molar, Third/*surgery MH - Multivariate Analysis MH - Oximetry MH - Oxygen/*blood MH - Oxygen Consumption/drug effects MH - Prilocaine/administration & dosage MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Vasoconstrictor Agents/*administration & dosage EDAT- 2002/01/22 10:00 MHDA- 2002/02/09 10:01 CRDT- 2002/01/22 10:00 PHST- 2002/01/22 10:00 [pubmed] PHST- 2002/02/09 10:01 [medline] PHST- 2002/01/22 10:00 [entrez] PST - ppublish SO - Bull Group Int Rech Sci Stomatol Odontol. 2000 Jan-Apr;42(1):1-10. PMID- 25925999 OWN - NLM STAT- MEDLINE DCOM- 20170111 LR - 20181113 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 19 IP - 4 DP - 2015 Dec TI - Safety of adjunct pre-emptive intravenous tramadol with midazolam sedation for third molar surgery. PG - 353-9 LID - 10.1007/s10006-015-0502-9 [doi] AB - PURPOSE: The purpose of this study was to evaluate patient safety, in terms of adverse events, alterations in blood pressure or oxygen saturation (SpO2) in two routine sedation procedures, with and without intravenous analgesia. METHODS: Patients referred for surgical removal of mandibular third molars were treated in a randomized, controlled, single-blinded procedure. Eighty-seven men and women, aged 18 to 44 years, were allotted to either of two treatment groups, midazolam + tramadol (M + T) and midazolam + saline (M + S) or to a control group (C), given no sedation. RESULTS: Tramadol at 1 mg/kg body weight resulted in a higher frequency of oxygen desaturation (SpO2 < 90 %) than a placebo (p = 0.002) but had no effect on mean SpO2 at the end point or at the end of surgery. In both the test groups, there was a significant decrease in diastolic blood pressure (p < 0.001) from baseline to the end of surgery. CONCLUSION: The results confirm that pre-emptive intravenous tramadol, administered at 1 mg/kg body weight as an adjunct to midazolam sedation for third molar surgery, offers a safe method. But, it should be noted that our previous study shows that it is not a particularly effective analgesic. Further testing is therefore warranted, using other doses or other drugs, to find a better intravenous protocol for postoperative analgesia, with maximum effect and minimal risk, in outpatient oral and maxillofacial surgery procedures. FAU - Eriksson, Lars B AU - Eriksson LB AD - Department of Oral and Maxillofacial Surgery, County Hospital, Falu Lasarett, 791 82, Falun, Sweden. lars.b.eriksson@ltdalarna.se. FAU - Tegelberg, Åke AU - Tegelberg Å AD - Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö University, 205 06, Malmö, Sweden. AD - Centre for Clinical research Uppsala University, County Hospital, 721 89, Västerås, Sweden. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150430 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 0 (Hypnotics and Sedatives) RN - 39J1LGJ30J (Tramadol) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Administration, Intravenous MH - Adult MH - Female MH - Humans MH - Hypnotics and Sedatives/administration & dosage/adverse effects/pharmacology MH - Male MH - Midazolam/*pharmacology MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology MH - *Patient Safety MH - Tooth Extraction/adverse effects/*methods MH - Tooth, Impacted/*surgery MH - Tramadol/*administration & dosage/adverse effects/*pharmacology MH - Young Adult OTO - NOTNLM OT - Adverse effects OT - Analgesics OT - Blood pressure OT - Opioid OT - Pain OT - Patient safety EDAT- 2015/05/01 06:00 MHDA- 2017/01/12 06:00 CRDT- 2015/05/01 06:00 PHST- 2014/12/07 00:00 [received] PHST- 2015/04/20 00:00 [accepted] PHST- 2015/05/01 06:00 [entrez] PHST- 2015/05/01 06:00 [pubmed] PHST- 2017/01/12 06:00 [medline] AID - 10.1007/s10006-015-0502-9 [pii] AID - 10.1007/s10006-015-0502-9 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2015 Dec;19(4):353-9. doi: 10.1007/s10006-015-0502-9. Epub 2015 Apr 30. PMID- 17954317 OWN - NLM STAT- MEDLINE DCOM- 20071206 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 65 IP - 11 DP - 2007 Nov TI - Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study. PG - 2218-26 AB - PURPOSE: The purpose of this study was to evaluate the effect of submucosal administration of dexamethasone sodium phosphate on discomfort after mandibular third molar surgery. PATIENTS AND METHODS: Sixty-one consecutive patients requiring surgical removal of a single mandibular impacted third molar under local anesthesia were randomly placed into 3 groups. After the onset of local anesthesia, the experimental groups received dexamethasone at 2 different doses (4 or 8 mg) as submucosal injection, and the control group received no drug. Standardized surgical and analgesic protocols were followed. Maximum interincisal distance and facial contours were measured at baseline and at postsurgery days 2 and 7. Pain was objectively measured by counting the number of analgesic tablets required. The patients' perception of the severity of symptoms was assessed with a follow-up questionnaire (PoSSe scale). RESULTS: On the second postoperative day, facial edema showed a statistically significant reduction in both dexamethasone 4-mg and dexamethasone 8-mg groups compared with the control group, but no statistically significant differences were observed between the 2 dosage regimens of dexamethasone. By contrast, there was no statistically significant difference between all groups when postoperative swelling was evaluated at day 7 (P > .50). The treatment group had a limited and nonsignificant effect on pain and trismus when compared with the control group at the 2 times of evaluation. CONCLUSIONS: Parenteral use of dexamethasone 4 mg, given as an intraoral injection at the time of surgery, is effective in the prevention of postoperative edema. Increasing the dose to 8 mg provides no further benefit. FAU - Grossi, Giovanni Battista AU - Grossi GB AD - Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy. gb.grossi@icp.mi.it FAU - Maiorana, Carlo AU - Maiorana C FAU - Garramone, Rocco Alberto AU - Garramone RA FAU - Borgonovo, Andrea AU - Borgonovo A FAU - Beretta, Mario AU - Beretta M FAU - Farronato, Davide AU - Farronato D FAU - Santoro, Franco AU - Santoro F LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 362O9ITL9D (Acetaminophen) RN - 7S5I7G3JQL (Dexamethasone) SB - AIM SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthesia, Local MH - Anti-Inflammatory Agents/*administration & dosage MH - Dexamethasone/*administration & dosage MH - Edema/prevention & control MH - Face MH - Female MH - Follow-Up Studies MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Mouth Mucosa MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Postoperative Complications/*prevention & control MH - Prospective Studies MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Trismus/prevention & control EDAT- 2007/10/24 09:00 MHDA- 2007/12/07 09:00 CRDT- 2007/10/24 09:00 PHST- 2006/07/06 00:00 [received] PHST- 2006/10/12 00:00 [revised] PHST- 2006/11/19 00:00 [accepted] PHST- 2007/10/24 09:00 [pubmed] PHST- 2007/12/07 09:00 [medline] PHST- 2007/10/24 09:00 [entrez] AID - S0278-2391(06)02205-1 [pii] AID - 10.1016/j.joms.2006.11.036 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2007 Nov;65(11):2218-26. doi: 10.1016/j.joms.2006.11.036. PMID- 31604060 OWN - NLM STAT- MEDLINE DCOM- 20200917 LR - 20200917 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 78 IP - 2 DP - 2020 Feb TI - Is Low-Level Laser Therapy Effective for Pain Control After the Surgical Removal of Unerupted Third Molars? A Randomized Trial. PG - 184-189 LID - S0278-2391(19)31074-2 [pii] LID - 10.1016/j.joms.2019.08.029 [doi] AB - PURPOSE: One of the main challenges after extraction of unerupted third molars is pain control, and one of the treatments for pain control is low-level laser therapy (LLLT). Thus, this study aimed to assess the effectiveness of LLLT for pain control after extraction of lower third molars. MATERIALS AND METHODS: This randomized, double-blind, split-mouth study included patients who required bilateral extraction of unerupted lower third molars. Patients received LLLT on 1 side (laser group) but not on the opposite side (control group). On the experimental side, each patient received a laser application at 5 intraoral points for 30 seconds per point. This procedure was simulated on the control side. The pain control response was assessed with a modified pain visual analog scale at the following times: immediately after surgery (T0), after laser application (T1), 24 hours after surgery (T2), 48 hours after surgery (T3), and 72 hours after surgery (T4). RESULTS: Thirty-two patients, 56.25% of whom were women, underwent extraction; the average age was 22.2 years. At the times analyzed, the laser group presented better results than the control group. As for the times, there were differences in pain scores between T0 (8.03 ± 14.87) and T3 (2.66 ± 4.23), as well as T4 (3.36 ± 7.83), in the laser group and differences between T0 (19.76 ± 26.66) and T3 (7.11 ± 10.76), as well as T4 (6.26 ± 13.14), in the control group. CONCLUSION: LLLT was effective in reducing pain after surgical removal of unerupted third molars. At T3 and T4, pain reduction in relation to T0 was noted in both groups. CI - Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Santos, Pâmela Letícia AU - Santos PL AD - Assistant Professor, Department of Health Sciences, Implantology Post Graduation Course, Dental School, University of Araraquara, Araraquara, Brazil. Electronic address: pamelalsantos@hotmail.com. FAU - Marotto, Ana Paula AU - Marotto AP AD - Surgeon-Dentist, Department of Health Sciences, University of Araraquara (UNIARA), Araraquara, São Paulo, Brazil. FAU - Zatta da Silva, Thaiz AU - Zatta da Silva T AD - Department of Health Sciences, University of Araraquara (UNIARA), Araraquara, São Paulo, Brazil. FAU - Bottura, Mariele Pecorali AU - Bottura MP AD - Surgeon-Dentist, Department of Health Sciences, University of Araraquara (UNIARA), Araraquara, São Paulo, Brazil. FAU - Valencise, Mayra AU - Valencise M AD - Surgeon-Dentist, Department of Health Sciences, University of Araraquara (UNIARA), Araraquara, São Paulo, Brazil. FAU - Marques, Daniela Oliveira AU - Marques DO AD - Department of Health Sciences, University of Araraquara (UNIARA), Araraquara, São Paulo, Brazil. FAU - Queiroz, Thallita Pereira AU - Queiroz TP AD - Assistant Professor, Department of Health Sciences, Implantology Post Graduation Course, Dental School, University of Araraquara, Araraquara, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190914 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - *Low-Level Light Therapy MH - *Molar, Third MH - Pain MH - Pain Management MH - Pain, Postoperative MH - Tooth Extraction MH - Young Adult EDAT- 2019/10/12 06:00 MHDA- 2020/09/18 06:00 CRDT- 2019/10/12 06:00 PHST- 2019/05/20 00:00 [received] PHST- 2019/08/27 00:00 [revised] PHST- 2019/08/28 00:00 [accepted] PHST- 2019/10/12 06:00 [pubmed] PHST- 2020/09/18 06:00 [medline] PHST- 2019/10/12 06:00 [entrez] AID - S0278-2391(19)31074-2 [pii] AID - 10.1016/j.joms.2019.08.029 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2020 Feb;78(2):184-189. doi: 10.1016/j.joms.2019.08.029. Epub 2019 Sep 14. PMID- 20206429 OWN - NLM STAT- MEDLINE DCOM- 20100504 LR - 20181201 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 68 IP - 5 DP - 2010 May TI - Analgesic and anti-inflammatory effects of oxaprozin and naproxen sodium after removal of impacted lower third molars: a randomized, double-blind, placebo-controlled crossover study. PG - 1018-24 LID - 10.1016/j.joms.2009.09.094 [doi] AB - PURPOSE: In this study, oxaprozin, a long-acting nonsteroidal anti-inflammatory drug, and naproxen sodium were compared in terms of their effects on edema, pain, and trismus after surgery for impacted mandibular third molars. MATERIALS AND METHODS: Thirty healthy patients with bilaterally impacted mandibular third molars were included in this randomized, cross-over, double-blind, placebo-controlled study. Patients were assigned randomly to 1 of 3 surgery groups and received postoperatively 1,200 mg oxaprozin, 550 mg naproxen sodium, or a placebo. Postoperative edema was measured with ultrasonography performed before and after surgery. Trismus was measured by comparison of preoperative and postoperative maximum interincisal mouth opening measurements by caliper. Pain was assessed by a visual analog scale (VAS) and by recording the number of rescue analgesic pills taken. RESULTS: After removal of impacted third molars, the patients administered oxaprozin and naproxen showed superior results over those given placebo in terms of pain parameters (P < .05), but these treatments had no statistically significant effect on facial swelling. Comparing the oxaprozin and naproxen groups, there were no differences in the mouth opening measurements, but naproxen showed a statistically superior effect over the placebo (P < .05). Although not statistically significant, oxaprozin showed a more pronounced effect in reducing trismus than did the placebo (P = .07). CONCLUSIONS: Administration of either oxaprozin or naproxen sodium during the postoperative period is effective and has similar effects in reducing pain but questionable benefit for the management of trismus. However, neither agent has clinical benefit in terms of reducing edema. CI - Crown Copyright 2010. Published by Elsevier Inc. All rights reserved. FAU - Kara, Isa M AU - Kara IM AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey. phismer@yahoo.com FAU - Polat, Serkan AU - Polat S FAU - Inci, M Fatih AU - Inci MF FAU - Gümüş, Cesur AU - Gümüş C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20100305 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 0 (Propionates) RN - 57Y76R9ATQ (Naproxen) RN - MHJ80W9LRB (Oxaprozin) SB - AIM SB - D SB - IM EIN - J Oral Maxillofac Surg. 2010 Aug;68(8):2036 EIN - J Oral Maxillofac Surg. 2011 Dec;69(12):3051. Ince, Fatih [corrected to Inci, M Fatih] MH - Adolescent MH - Anti-Inflammatory Agents/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Edema/prevention & control MH - Face MH - Female MH - Humans MH - Male MH - Mandible/physiopathology MH - Molar, Third/*surgery MH - Naproxen/*therapeutic use MH - Oxaprozin MH - Pain, Postoperative/prevention & control MH - Placebos MH - Propionates/*therapeutic use MH - Prospective Studies MH - Range of Motion, Articular/physiology MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control MH - Young Adult EDAT- 2010/03/09 06:00 MHDA- 2010/05/05 06:00 CRDT- 2010/03/09 06:00 PHST- 2009/05/11 00:00 [received] PHST- 2009/08/27 00:00 [revised] PHST- 2009/09/23 00:00 [accepted] PHST- 2010/03/09 06:00 [entrez] PHST- 2010/03/09 06:00 [pubmed] PHST- 2010/05/05 06:00 [medline] AID - S0278-2391(09)01836-9 [pii] AID - 10.1016/j.joms.2009.09.094 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2010 May;68(5):1018-24. doi: 10.1016/j.joms.2009.09.094. Epub 2010 Mar 5. PMID- 20970963 OWN - NLM STAT- MEDLINE DCOM- 20110621 LR - 20171116 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 40 IP - 2 DP - 2011 Feb TI - Povidone-iodine: an anti-oedematous agent? PG - 173-6 LID - 10.1016/j.ijom.2010.09.012 [doi] AB - Polyvinylpyrrolidone-iodine (PVP-I) is a well-known antiseptic, widely used in various preparations and concentrations in all surgical fields. It is also used as an irrigant for open wounds and in some centres for irrigating sockets after tooth extraction. One of the authors (GA) incidentally discovered an anti-oedematous effect of PVP-I after using it in low concentration as an irrigant/coolant during the surgical removal of lower third molars. A prospective randomized clinical trial was subsequently performed on 50 patients (25 control, 25 treatment group) undergoing removal of impacted lower third molars. In the treatment group a 0.5% PVP-I solution at a concentration of 0.5mg/ml (we call it as "Arakeri's iodine solution") resulted in a significant reduction in postoperative swelling compared with the control group (P<0.01). This effect of PVP-I was suspected due to its inhibitory effect on leukotriene B4 and leukocyte extravasation (chemotaxis). Further evaluation of the effects of PVP-I as an irrigant in oral and maxillofacial surgery is needed. CI - Copyright © 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Arakeri, Gururaj AU - Arakeri G AD - Peter Brennan's Indian Academy of Craniofacial Research, Shahapur, Karnataka, India. gururaj.arakeri@gmail.com FAU - Brennan, Peter A AU - Brennan PA LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20101030 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Infective Agents, Local) RN - 1HGW4DR56D (Leukotriene B4) RN - 85H0HZU99M (Povidone-Iodine) SB - D SB - IM MH - Adult MH - Anti-Infective Agents, Local/pharmacology/*therapeutic use MH - Chemotaxis, Leukocyte/drug effects MH - Edema/*drug therapy/etiology MH - Female MH - Humans MH - Leukotriene B4/antagonists & inhibitors MH - Male MH - Mandible MH - Molar, Third/surgery MH - Povidone-Iodine/pharmacology/*therapeutic use MH - Prospective Studies MH - Single-Blind Method MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Young Adult EDAT- 2010/10/26 06:00 MHDA- 2011/06/22 06:00 CRDT- 2010/10/26 06:00 PHST- 2009/10/22 00:00 [received] PHST- 2010/05/18 00:00 [revised] PHST- 2010/09/13 00:00 [accepted] PHST- 2010/10/26 06:00 [entrez] PHST- 2010/10/26 06:00 [pubmed] PHST- 2011/06/22 06:00 [medline] AID - S0901-5027(10)00405-4 [pii] AID - 10.1016/j.ijom.2010.09.012 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2011 Feb;40(2):173-6. doi: 10.1016/j.ijom.2010.09.012. Epub 2010 Oct 30. PMID- 22918011 OWN - NLM STAT- MEDLINE DCOM- 20130318 LR - 20191027 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 13 IP - 3 DP - 2012 May 1 TI - Analgesic efficacy of tramadol and butorphanol in mandibular third molar surgery: a comparative study. PG - 364-70 AB - BACKGROUND: Butorphanol tartrate, a mixed synthetic agonistantagonist opioid analgesic has been used for management of postoperative pain in minor and major surgical procedures.(14,20) Tramadol hydrochloride is a centrally acting opioid which is effectively used in postoperative pain in various minor and major surgeries. MATERIALS AND METHODS: Twenty subjects selected randomly received butorphanol tartrate 1 mg intramuscular and 20 subjects received tramadol hydrochloride 50 mg intramuscular after the removal of mandibular third molars. Time of injection, amount of anesthetic injected, duration of surgery, adverse effects were recorded.(21) RESULTS: The mean amount of LA administered in butorphanol group was 2.6450 ml and in tramadol group was 2.640 ml respectively, the mean duration for surgery was 56.75 and 53.5 minutes for butorphanol and tramadol groups respectively which was statistically not significant. Pain assessment was done with VAS which showed mean of 19.2 and 15.5 mm (p = 0.001) which was significant for butorphanol and tramadol respectively after 12 hours. The mean time for rescue medication requirement was 5.9 hours (for tramadol) and 8.4 hours (for butorphanol). Effective analgesic activity was seen by butorphanol 1 mg intramuscular then tramadol 50 mg. CONCLUSION: Butorphanol 1 mg was more effective than tramadol 50 mg in respect to postoperative analgesia. FAU - Hassan, Syed Sirajul AU - Hassan SS AD - Assistant Professor, Department of Oral and Maxillofacial Surgery Farooqia Dental College, Mysore, Karnataka, India. siraj827@hotmail.com FAU - Ahmed, Anees AU - Ahmed A FAU - Rai, Manjunath AU - Rai M FAU - Kalappa, T M AU - Kalappa TM LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20120501 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 RN - 0 (Analgesics, Opioid) RN - 39J1LGJ30J (Tramadol) RN - QV897JC36D (Butorphanol) SB - D SB - IM MH - Analgesics, Opioid/*administration & dosage MH - Butorphanol/*administration & dosage MH - Chi-Square Distribution MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Operative Time MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Sex Distribution MH - Statistics, Nonparametric MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Tramadol/*administration & dosage MH - Young Adult EDAT- 2012/08/25 06:00 MHDA- 2013/03/19 06:00 CRDT- 2012/08/25 06:00 PHST- 2012/08/25 06:00 [entrez] PHST- 2012/08/25 06:00 [pubmed] PHST- 2013/03/19 06:00 [medline] AID - 1526-3711-886 [pii] AID - 10.5005/jp-journals-10024-1152 [doi] PST - epublish SO - J Contemp Dent Pract. 2012 May 1;13(3):364-70. doi: 10.5005/jp-journals-10024-1152. PMID- 16930785 OWN - NLM STAT- MEDLINE DCOM- 20070702 LR - 20181201 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 45 IP - 3 DP - 2007 Apr TI - A comparison of midazolam and midazolam with remifentanil for patient-controlled sedation during operations on third molars. PG - 212-6 AB - Our aim was to compare patients' satisfaction and cooperation, and clinical efficacy, of midazolam alone, and midazolam and remifentanil for patient-controlled sedation during removal of third molars. Forty patients, American Society of Anesthesiologists grades I and II, admitted for extraction of impacted mandibular third molars were included in this randomised, prospective study. They were given an intravenous bolus of midazolam 0.03 mg/kg and then allowed to use patient-controlled sedation. In the midazolam group, 2 ml of 0.5 mg/ml midazolam was given automatically. In the midazolam-remifentanil group, 2 ml of 0.5 mg/ml midazolam and 12.5 microg/ml remifentanil were given in the same manner. The lockout period was 5 min. Vital signs and oxygen saturation were recorded. Patients' and surgeons' satisfaction, and the patients' degree of amnesia about the local anaesthetic, drilling, removal of the tooth, and pain during extraction were also assessed. There were no significant differences between systolic and diastolic blood pressures during sedation, but heart rate after 30 min in the combined group was significantly lower than in the midazolam group (p<0.05). Surgeons described the midazolam group as excellent in 9 and good in 11. In the combined group, satisfaction was excellent in 11, good in 7, and satisfactory or unacceptable in 1 of each. Immediately postoperatively, 19 patients in each group ranked their satisfaction as excellent and 1 as good. Twenty-four hours later it was unchanged in the midazolam group, while 15 patients in the other group thought it was excellent, 3 good, and 2 poor. Patient-controlled analgesia with midazolam or midazolam and remifentanil is safe and reliable during extraction of third molars. FAU - Garip, Hasan AU - Garip H AD - Department of OMFS, Marmara University, Turkey. hasangarip04@yahoo.com FAU - Gürkan, Yavuz AU - Gürkan Y FAU - Toker, Kamil AU - Toker K FAU - Göker, Kamil AU - Göker K LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20060823 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Hypnotics and Sedatives) RN - 0 (Piperidines) RN - P10582JYYK (Remifentanil) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Local MH - Blood Pressure/drug effects MH - Conscious Sedation/*methods MH - Cooperative Behavior MH - Female MH - Heart Rate/drug effects MH - Humans MH - Hypnotics and Sedatives/*administration & dosage MH - Male MH - Mandible/surgery MH - Mental Recall/drug effects MH - Midazolam/*administration & dosage MH - Molar, Third/*surgery MH - Pain/prevention & control MH - Patient Satisfaction MH - Piperidines/*administration & dosage MH - Prospective Studies MH - Remifentanil MH - *Self Administration MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Treatment Outcome EDAT- 2006/08/26 09:00 MHDA- 2007/07/03 09:00 CRDT- 2006/08/26 09:00 PHST- 2006/06/08 00:00 [accepted] PHST- 2006/08/26 09:00 [pubmed] PHST- 2007/07/03 09:00 [medline] PHST- 2006/08/26 09:00 [entrez] AID - S0266-4356(06)00104-5 [pii] AID - 10.1016/j.bjoms.2006.06.002 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2007 Apr;45(3):212-6. doi: 10.1016/j.bjoms.2006.06.002. Epub 2006 Aug 23. PMID- 9882082 OWN - NLM STAT- MEDLINE DCOM- 19990415 LR - 20180612 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 38 IP - S1 DP - 1998 Dec TI - Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain. PG - 46S-54S AB - The efficacy and tolerability of single doses of dexketoprofen trometamol 12.5 mg, 25 mg, and 50 mg and ketoprofen 50 mg were compared in this double-blind, randomized, placebo-controlled study of 210 patients with moderate to severe pain after removal of one mandibular impacted third molar tooth. Pain intensity and pain relief were monitored for 6 h after administration of medication using visual analogue and verbal rating scales. All four active treatments were significantly more effective than placebo (P < 0.001). Dexketoprofen 25 mg and 50 mg produced an analgesic effect within 30 min of administration and their effect persisted for 6 h. Ketoprofen 50 mg produced a level of analgesia similar to those of the higher doses of dexketoprofen trometamol, but it had a slower onset. The 12.5-mg dose of dexketoprofen trometamol was significantly superior to placebo but produced a lower level and shorter duration of analgesia compared to the other active treatments. There were no significant differences between 25 and 50 mg of dexketoprofen trometamol in any measure of analgesic efficacy. No serious adverse events were observed and there were no significant differences in the incidence of adverse events among treatment groups. These results demonstrate that dexketoprofen trometamol 25 mg is at least as effective as the racemic ketoprofen 50 mg in the treatment of postsurgical dental pain. The more rapid onset of action compared to ketoprofen suggests that dexketoprofen trometamol is more appropriate for treatment of acute pain. FAU - McGurk, M AU - McGurk M AD - Department of Oral and Maxillofacial Surgery, Guy's Hospital, London, UK. FAU - Robinson, P AU - Robinson P FAU - Rajayogeswaran, V AU - Rajayogeswaran V FAU - De Luca, M AU - De Luca M FAU - Casini, A AU - Casini A FAU - Artigas, R AU - Artigas R FAU - Muñoz, G AU - Muñoz G FAU - Mauleón, D AU - Mauleón D LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 023C2WHX2V (Tromethamine) RN - 90Y4QC304K (Ketoprofen) RN - N674F7L21E (dexketoprofen trometamol) SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Ketoprofen/adverse effects/*analogs & derivatives/pharmacology/*therapeutic use/toxicity MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Treatment Outcome MH - Tromethamine/*analogs & derivatives/pharmacology/toxicity EDAT- 1999/01/09 00:00 MHDA- 1999/01/09 00:01 CRDT- 1999/01/09 00:00 PHST- 1999/01/09 00:00 [pubmed] PHST- 1999/01/09 00:01 [medline] PHST- 1999/01/09 00:00 [entrez] PST - ppublish SO - J Clin Pharmacol. 1998 Dec;38(S1):46S-54S. PMID- 16140544 OWN - NLM STAT- MEDLINE DCOM- 20051222 LR - 20150831 IS - 1043-6618 (Print) IS - 1043-6618 (Linking) VI - 52 IP - 6 DP - 2005 Dec TI - Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. PG - 485-90 AB - Combined treatments with non-steroidal anti-inflammatory drugs and antibiotics may offer significant benefits in the prevention of pain and infections associated with oral surgery. In this study, piroxicam and azithromycin were administered to patients undergoing dental extraction to examine the efficacy of piroxicam in the prevention of post-operative pain and inflammatory complications, either in the absence or in the presence of a concomitant antibiotic treatment. Thirty patients were randomly assigned to three groups and treated for 3 days, before impacted lower third molar removal, as follows: (1) sublingual piroxicam-FDDF (fast dissolving dosage formulation) 20 mg/day; (2) oral azithromycin 500 mg/day; (3) piroxicam-FDDF 20 mg/day plus azithromycin 500 mg/day. Oral acetaminophen (500 mg tablets) was allowed as rescue analgesic medication. Pain intensity was evaluated on a 100-mm visual-analogue scale after dental extraction (day 1), and at days 2, 3, 7 after surgery. Edema and trismus were estimated at days 2 and 7. At days 1 and 2, pain intensity was significantly lower in patients treated with piroxicam-FDDF, either alone (p < 0.05) or in combination with azithromycin (p < 0.05), than in patients administered with azithromycin alone. A higher acetaminophen consumption was also recorded in the latter group (p < 0.01). Pain intensity values did not differ among treatment groups at days 3 and 7. At day 2, the facial edema was significantly less intense in patients exposed to piroxicam-FDDF alone, as compared to patients treated with azithromycin, either alone (p < 0.05) or in combination with piroxicam-FDDF (p < 0.05). No significant differences were detected when comparing groups for trismus at days 2 and 7. The present results indicate that, when given alone in the pre-operative period, piroxicam-FDDF effectively counteracts post-surgical pain and inflammatory reactions in oral tissues. Upon combined treatment with piroxicam-FDDF and azithromycin, the macrolide antibiotic may reduce the influence of piroxicam on post-operative inflammation, without affecting its beneficial effect on surgical pain. FAU - Graziani, F AU - Graziani F AD - Section of Oral Surgery, Department of Neurosciences, University of Pisa, Italy. FAU - Corsi, L AU - Corsi L FAU - Fornai, M AU - Fornai M FAU - Antonioli, L AU - Antonioli L FAU - Tonelli, M AU - Tonelli M FAU - Cei, S AU - Cei S FAU - Colucci, R AU - Colucci R FAU - Blandizzi, C AU - Blandizzi C FAU - Gabriele, M AU - Gabriele M FAU - Del Tacca, M AU - Del Tacca M LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20050902 PL - Netherlands TA - Pharmacol Res JT - Pharmacological research JID - 8907422 RN - 0 (Anti-Bacterial Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 83905-01-5 (Azithromycin) SB - IM MH - Adolescent MH - Adult MH - Anti-Bacterial Agents/*administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Azithromycin/*administration & dosage MH - Drug Therapy, Combination MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*administration & dosage MH - Postoperative Complications/*prevention & control MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control EDAT- 2005/09/06 09:00 MHDA- 2005/12/24 09:00 CRDT- 2005/09/06 09:00 PHST- 2005/06/08 00:00 [received] PHST- 2005/07/27 00:00 [revised] PHST- 2005/07/29 00:00 [accepted] PHST- 2005/09/06 09:00 [pubmed] PHST- 2005/12/24 09:00 [medline] PHST- 2005/09/06 09:00 [entrez] AID - S1043-6618(05)00150-7 [pii] AID - 10.1016/j.phrs.2005.07.009 [doi] PST - ppublish SO - Pharmacol Res. 2005 Dec;52(6):485-90. doi: 10.1016/j.phrs.2005.07.009. Epub 2005 Sep 2. PMID- 16243240 OWN - NLM STAT- MEDLINE DCOM- 20060222 LR - 20121115 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 100 IP - 5 DP - 2005 Nov TI - The effects on postoperative oral surgery pain by varying NSAID administration times: comparison on effect of preemptive analgesia. PG - 559-63 AB - OBJECTIVE: Many studies on the efficacy of preemptive analgesia have been processed in different ways. But the value of preemptive analgesia is still controversial. The goal of this study was to compare analgesic effects of a nonsteroidal anti-inflammatory drug (NSAID) for oral surgical pain according to 3 different administration times. STUDY DESIGN: Using a randomized, parallel-group, single-center, and active-controlled test design, this study was conducted with 80 healthy patients undergoing a surgical removal of an impacted mandibular third molar requiring bone removal. The oral NSAID was first administered 1 hour preoperatively, or 1 hour postoperatively, or no scheduled administration pre- or postsurgery. Whenever patients felt at least moderate pain (score > or =5 on a 10-point scale) after surgery, they were instructed to take the same drug. Pain intensities and times to the first and second onsets of postoperative pain from the end of surgery were assessed for 24 hours. RESULTS: Of the 80 enrolled subjects in this study, 25 patients were assigned to the preemptive group, 26 to the posttreatment group, and 29 to the no-treatment group. The demographic distribution and duration of surgery in the 3 groups were statistically similar. The mean time to first onset of postoperative pain was significantly prolonged in the posttreatment group (277.2 minutes, P < .05) compared to the preemptive group (158.4 minutes) and the no-treatment group (196.5 minutes). The mean time to second onset of postoperative pain was not significantly different among the 3 groups. No significant statistical difference was found among the mean pain intensities at the first and second onsets of postoperative pain in the 3 groups. CONCLUSIONS: In this small selected group of subjects and limited study design, the analgesic effects of NSAID administered preoperatively were no longer effective for postoperative pain. The results in this population imply that scheduled postoperative analgesics before pain development are adequate for postoperative analgesia without preoperative administration. FAU - Jung, Young-Soo AU - Jung YS AD - Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea. FAU - Kim, Moon-Key AU - Kim MK FAU - Um, Yoo Jung AU - Um YJ FAU - Park, Hyung-Sik AU - Park HS FAU - Lee, Eui-Wung AU - Lee EW FAU - Kang, Jeong-Wan AU - Kang JW LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Benzofurans) RN - 0 (Pyridines) RN - JFK78S0U9S (talniflumate) SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents/*administration & dosage MH - Benzofurans/*administration & dosage MH - Chi-Square Distribution MH - Double-Blind Method MH - Facial Pain/drug therapy MH - Female MH - Humans MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy/etiology MH - Postoperative Care MH - Preoperative Care MH - Pyridines/*administration & dosage MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 2005/10/26 09:00 MHDA- 2006/02/24 09:00 CRDT- 2005/10/26 09:00 PHST- 2004/07/27 00:00 [received] PHST- 2005/02/11 00:00 [revised] PHST- 2005/02/24 00:00 [accepted] PHST- 2005/10/26 09:00 [pubmed] PHST- 2006/02/24 09:00 [medline] PHST- 2005/10/26 09:00 [entrez] AID - S1079-2104(05)00173-3 [pii] AID - 10.1016/j.tripleo.2005.02.065 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Nov;100(5):559-63. doi: 10.1016/j.tripleo.2005.02.065. PMID- 26615509 OWN - NLM STAT- MEDLINE DCOM- 20161104 LR - 20190609 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 21 IP - 1 DP - 2016 Jan 1 TI - Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery. PG - e127-34 AB - BACKGROUND: Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction. MATERIAL AND METHODS: A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus. RESULTS: The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed. CONCLUSIONS: Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions. FAU - Orozco-Solís, Mariana AU - Orozco-Solís M AD - Facultad de Odontología, Universidad Autónoma de Baja California, Calle Zotoluca y Chinampas s/n, Fraccionamiento Calafia, C.P. 21040; Mexicali, México, isiordia81@yahoo.com.mx. FAU - García-Ávalos, Yazmín AU - García-Ávalos Y FAU - Pichardo-Ramírez, Celeste AU - Pichardo-Ramírez C FAU - Tobías-Azúa, Francisco AU - Tobías-Azúa F FAU - Zapata-Morales, Juan-Ramón AU - Zapata-Morales JR FAU - Aragon-Martínez, Othoniel-Hugo AU - Aragon-Martínez OH FAU - Isiordia-Espinoza, Mario-Alberto AU - Isiordia-Espinoza MA LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20160101 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Thiazines) RN - 0 (Thiazoles) RN - 144O8QL0L1 (Diclofenac) RN - VG2QF83CGL (Meloxicam) SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Diclofenac/*administration & dosage MH - Double-Blind Method MH - Edema/etiology/*prevention & control MH - Female MH - Humans MH - Male MH - Meloxicam MH - Molar, Third/*surgery MH - Pain, Postoperative/etiology/*prevention & control MH - Thiazines/*administration & dosage MH - Thiazoles/*administration & dosage MH - *Tooth Extraction/adverse effects MH - Trismus/etiology/*prevention & control MH - Young Adult PMC - PMC4765749 COIS- Conflict of interest statement: The authors have declared that no conflict of interest exist. EDAT- 2015/11/30 06:00 MHDA- 2016/11/05 06:00 CRDT- 2015/11/30 06:00 PHST- 2015/07/04 00:00 [received] PHST- 2015/08/04 00:00 [accepted] PHST- 2015/11/30 06:00 [entrez] PHST- 2015/11/30 06:00 [pubmed] PHST- 2016/11/05 06:00 [medline] AID - 20925 [pii] AID - 10.4317/medoral.20925 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2016 Jan 1;21(1):e127-34. doi: 10.4317/medoral.20925. PMID- 15105203 OWN - NLM STAT- MEDLINE DCOM- 20040519 LR - 20190704 IS - 0003-2999 (Print) IS - 0003-2999 (Linking) VI - 98 IP - 5 DP - 2004 May TI - Sedation with midazolam leads to reduced pain after dental surgery. PG - 1289-93, table of contents AB - Our principal objective in this study was to evaluate the potential pain reducing effect of i.v. midazolam in patients undergoing oral surgery. One-hundred-twenty-five patients with impacted mandibular third molars requiring removal under local anesthetic were randomized into 2 groups. The first group (n = 64) was administered i.v. midazolam by titration until a clinical end-point of conscious sedation followed by local anesthetic before surgery; the second group (n = 61) was the control and was administered only local anesthetic before surgery. The surgery was performed in a standardized manner in both groups by the same surgeon. Outcome measures were four primary end-points: pain intensity as assessed by a 100-mm visual analogue scale and a 4-point categorized scale hourly for 8 h, time to first analgesic, total analgesic (ibuprofen) consumption over the first 48 h, and a 5-point categorical patient global assessment scale (0 = poor, 1 = fair, 2 = good, 3 = very good, and 4 = excellent). Throughout the 8-h investigation period, patients in the midazolam group reported significantly lower pain intensity scores than those in the control group (19.0 +/- 13.2 mm versus 28.1 +/- 12.8 mm, P < 0.05). The patients in the midazolam group also reported significantly longer time to first analgesic (165.5 +/- 56.5 min versus 202.2 +/- 79.0 min, P < 0.05), less analgesic consumption (1275 +/- 364 mg versus 1688 +/- 407 mg, P < 0.001) and better patient global assessment (3.34 +/- 0.8 versus 2.4 +/- 0.9, P < 0.001). We conclude that systemically administered midazolam is effective in reducing postoperative pain after third molar surgery. IMPLICATIONS: In this observer blinded study, we found that i.v. midazolam treatment (0.09 mg/kg) has a pain-reducing effect after third molar surgery, thus improving postoperative pain management. FAU - Ong, Cliff K S AU - Ong CK AD - Department of Oral & Maxillofacial Surgery, National University of Singapore. cliffong@pacific.net.sg FAU - Seymour, Robin A AU - Seymour RA FAU - Tan, Juliana M-H AU - Tan JM LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Anesth Analg JT - Anesthesia and analgesia JID - 1310650 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Hypnotics and Sedatives) RN - R60L0SM5BC (Midazolam) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - IM MH - Adult MH - Analgesics/administration & dosage/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/therapeutic use MH - Endpoint Determination MH - Female MH - Humans MH - *Hypnotics and Sedatives MH - Ibuprofen/administration & dosage/therapeutic use MH - Male MH - *Midazolam MH - Molar, Third/surgery MH - *Oral Surgical Procedures MH - Pain Measurement MH - Pain, Postoperative/drug therapy/*prevention & control MH - *Preanesthetic Medication MH - Single-Blind Method EDAT- 2004/04/24 05:00 MHDA- 2004/05/20 05:00 CRDT- 2004/04/24 05:00 PHST- 2004/04/24 05:00 [pubmed] PHST- 2004/05/20 05:00 [medline] PHST- 2004/04/24 05:00 [entrez] AID - 10.1213/01.ane.0000111107.18755.cc [doi] PST - ppublish SO - Anesth Analg. 2004 May;98(5):1289-93, table of contents. doi: 10.1213/01.ane.0000111107.18755.cc. PMID- 14558587 OWN - NLM STAT- MEDLINE DCOM- 20040416 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 50 IP - 3 DP - 2003 TI - An evaluation of analgesic efficacy and clinical acceptability of intravenous tramadol as an adjunct to propofol sedation for third molar surgery. PG - 121-8 AB - This article details a double-blind, randomized, placebo-controlled pilot study evaluating the analgesic efficacy and clinical acceptability of intravenous tramadol in patients undergoing surgical removal of an impacted third molar tooth under local anesthesia and intravenous sedation with propofol. Forty-five ASA status 1 dental outpatients were randomly allocated to 2 groups of 22 (group A) and 23 (group B) patients each (n = 45). Group A (T/P) received intravenous tramadol 1.5 mg/kg injected over 2 minutes, followed by a bolus dose of intravenous propofol 0.4 mg/ kg. Maintenance consisted of a continuous infusion of propofol 3 mg/kg/h, with an additional bolus dose of 0.4 mg/kg intravenously 2-3 minutes prior to the infiltration of the local anesthetic solution. Group B (P/P) patients received no tramadol but instead a saline placebo solution and an identical amount of propofol. Overall, in this study, postoperative pain was much better controlled in the group receiving tramadol 1.5 mg/kg intravenously despite there being no significant difference in the dose of propofol administered in both groups. Intravenous tramadol, when given with propofol, did not affect the cardiovascular, respiratory, and sedative effects of propofol. Following tramadol, despite being an opioid, no nausea and vomiting were reported in the early postoperative period, indicating the value of using tramadol with propofol. Thus, this pilot study demonstrated the potential use of intravenous tramadol with propofol in day-case dento-alveolar surgery. FAU - Shipton, E A AU - Shipton EA AD - Department of Anesthesiology, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand. FAU - Roelofse, J A AU - Roelofse JA FAU - Blignaut, R J AU - Blignaut RJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Analgesics, Opioid) RN - 0 (Anesthetics, Intravenous) RN - 0 (Placebos) RN - 39J1LGJ30J (Tramadol) RN - YI7VU623SF (Propofol) SB - D MH - Adult MH - Ambulatory Surgical Procedures MH - Analgesics, Opioid/administration & dosage/*therapeutic use MH - Anesthetics, Intravenous/*administration & dosage MH - *Conscious Sedation MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intravenous MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Pilot Projects MH - Placebos MH - Postoperative Nausea and Vomiting/prevention & control MH - Propofol/*administration & dosage MH - Tooth Extraction MH - Tooth, Impacted/surgery MH - Tramadol/administration & dosage/*therapeutic use MH - Treatment Outcome PMC - PMC2007436 EDAT- 2003/10/16 05:00 MHDA- 2004/04/17 05:00 CRDT- 2003/10/16 05:00 PHST- 2003/10/16 05:00 [pubmed] PHST- 2004/04/17 05:00 [medline] PHST- 2003/10/16 05:00 [entrez] PST - ppublish SO - Anesth Prog. 2003;50(3):121-8. PMID- 19168326 OWN - NLM STAT- MEDLINE DCOM- 20090827 LR - 20151119 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 38 IP - 4 DP - 2009 Apr TI - A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. PG - 350-5 LID - 10.1016/j.ijom.2008.12.013 [doi] AB - Assessment of postoperative sequelae following the removal of an impacted third molar has been used in clinical pharmacology to evaluate the relative efficacy of various analgesic, anti-inflammatory drugs. This study included 150 patients with impacted lower third molars. They were randomly sorted to receive ibuprofen, paracetamol, betamethasone, serratiopeptidase or placebo. Evaluation of efficacy was made using tape measurement (for swelling), visual analogue scale (for pain evaluation), mouth opening ability and oral temperature. The effect of treatment on hematological parameters, bleeding, wound healing and requirement for rescue medication was also studied. Peak pain scores were observed approximately 5-6 hours after the operation. Betamethasone showed significant analgesic activity from day 1. Ibuprofen and betamethasone were significantly more effective than placebo in reducing swelling. Trismus was least with betamethasone. A significant rise in temperature on the operated side occurred only on day 1 in all the groups. Serratiopeptidase did not showed significant analgesic and anti-inflammatory action. Mild-to-moderate adverse effects were reported. FAU - Chopra, D AU - Chopra D AD - Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India. drdeeptichopra@yahoo.co.in FAU - Rehan, H S AU - Rehan HS FAU - Mehra, P AU - Mehra P FAU - Kakkar, A K AU - Kakkar AK LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20090124 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - 9842X06Q6M (Betamethasone) RN - EC 3.4.- (Peptide Hydrolases) RN - NL053ABE4J (serratiopeptidase) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/*therapeutic use MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Betamethasone/therapeutic use MH - Double-Blind Method MH - Edema/drug therapy/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Ibuprofen/therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain, Postoperative/drug therapy/*prevention & control MH - Peptide Hydrolases/therapeutic use MH - Sex Factors MH - Statistics, Nonparametric MH - Tooth Extraction/*adverse effects/methods MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Young Adult EDAT- 2009/01/27 09:00 MHDA- 2009/08/28 09:00 CRDT- 2009/01/27 09:00 PHST- 2007/12/12 00:00 [received] PHST- 2008/06/09 00:00 [revised] PHST- 2008/12/16 00:00 [accepted] PHST- 2009/01/27 09:00 [entrez] PHST- 2009/01/27 09:00 [pubmed] PHST- 2009/08/28 09:00 [medline] AID - S0901-5027(08)00461-X [pii] AID - 10.1016/j.ijom.2008.12.013 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2009 Apr;38(4):350-5. doi: 10.1016/j.ijom.2008.12.013. Epub 2009 Jan 24. PMID- 12374912 OWN - NLM STAT- MEDLINE DCOM- 20030109 LR - 20190910 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 94 IP - 4 DP - 2002 Oct TI - Grafting mandibular third molar extraction sites: a comparison of bioactive glass to a nongrafted site. PG - 413-9 AB - OBJECTIVE: The purpose of this study was to evaluate the effectiveness of bioactive glass used as a graft material for regeneration of bone after the removal of impacted third molars. The healing distal to the second molars was followed, with documentation of the level of radiographic osseous fill and measurement of the changes in clinical attachment levels. METHODS: Fourteen (5 male and 9 female) patients completed the study at 1 year. After surgical removal of bilateral impacted third molars, one site was grafted with bioactive glass particles (BioGran, Orthovita, Malvern, Penn). The patients were followed up at 1 and 2 weeks after surgery for signs or symptoms of infection or any other complications that may have been related to the surgical procedures. At 3, 6, and 12 months, the clinical attachment levels distal to the second molars were assessed. At 6 and 12 months, radiographs were obtained to assess the amount of osseous fill distal to the second molars. RESULTS: A split-mouth design was used to test the efficacy of the grafting materials. Clinical attachment levels in the grafted sites were significantly higher than in the nongrafted sites. There was not a significant increase in bone formation when comparing the 2 sides at 1 year. CONCLUSION: This study suggests that treatment of third molar extraction sites with bioactive glass does significantly alter the clinical attachment level but not the level of osseous fill distal to the second molars after 1 year. FAU - Throndson, Roger R AU - Throndson RR AD - Department of Surgery, University of Texas Medical Branch Galveston, TX 77555-0531, USA. rrthrond@utmb.edu FAU - Sexton, S Barrett AU - Sexton SB LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Biocompatible Materials) RN - 0 (Biogran) RN - 0 (Bone Substitutes) SB - D SB - IM MH - Adult MH - Alveolar Process/pathology MH - Analysis of Variance MH - Biocompatible Materials/*therapeutic use MH - Bone Regeneration/physiology MH - Bone Substitutes/*therapeutic use MH - Female MH - Follow-Up Studies MH - Gingiva/pathology MH - *Glass MH - Humans MH - Male MH - Mandible/diagnostic imaging/physiopathology/*surgery MH - Molar/pathology MH - Molar, Third/*surgery MH - Periodontal Ligament/pathology MH - Radiography MH - Surgical Flaps MH - Tooth Cervix/pathology MH - *Tooth Extraction MH - Tooth Socket/diagnostic imaging/physiopathology/*surgery MH - Tooth, Impacted/*surgery EDAT- 2002/10/11 04:00 MHDA- 2003/01/10 04:00 CRDT- 2002/10/11 04:00 PHST- 2002/10/11 04:00 [pubmed] PHST- 2003/01/10 04:00 [medline] PHST- 2002/10/11 04:00 [entrez] AID - S1079210402002780 [pii] AID - 10.1067/moe.2002.127582 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Oct;94(4):413-9. doi: 10.1067/moe.2002.127582. PMID- 15452808 OWN - NLM STAT- MEDLINE DCOM- 20041130 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 62 IP - 10 DP - 2004 Oct TI - Management of mandibular third molar extraction sites to prevent periodontal defects. PG - 1213-24 AB - PURPOSE: Persistent periodontal defects on the distal aspect of the mandibular second molar (M2) is a reported complication of mandibular third molar (M3) extraction. The purpose of this study was to measure the efficacy of demineralized bone powder (DBP) or guided-tissue regeneration therapy (GTR therapy) in preventing periodontal defects on the distal aspect of the M2 following M3 extraction. MATERIALS AND METHODS: We implemented a single-blind, randomized, controlled clinical trial composed of a sample of subjects > or = 26 years of age who required extraction of bilateral M3s. The primary predictor variable was treatment group. Each subject was randomly assigned to receive either DBP or GTR therapy. Within subjects, 1 M3 site was randomly selected to be the experimental site and the opposite M3 served as a control and was permitted to heal without intervention. The primary outcome variable was the change in attachment levels (AL) and probing depths (PD) on the disto-buccal aspect of M2 between T 0 (immediate preoperatively) and T 4 (26 weeks postoperatively). Appropriate sample size estimates, descriptive, bivariate, and multivariate statistics were computed. RESULTS: Twelve subjects in the DBP group and 12 subjects in the GTR-therapy group completed the study. For both treatment and control sites, between T 0 and T 4, there were statistically significant improvements in AL (> or = 2.2 mm; P <.001) and PD (> or = 2.6 mm; P <.001). Within-subjects comparisons showed no significant differences in AL or PD between treatment and control M3 sites ( P > or =.3) at T 0 or T 4. CONCLUSION: The results of this study suggest that attachment levels and probing depths improve after M3 removal. In this sample, DBP or GTR therapy did not offer predictable benefit over no treatment. FAU - Dodson, Thomas B AU - Dodson TB AD - Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, 55 Fruit Street, Warren 1201, Boston, MA 02114, USA. tbdodson@partners.org LA - eng GR - K24 DE 00448/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Bone Substitutes) SB - AIM SB - D SB - IM MH - Absorbable Implants MH - Adult MH - Alveolar Bone Loss/etiology/prevention & control/therapy MH - Alveolar Process/*surgery MH - Bone Substitutes/therapeutic use MH - Female MH - Guided Tissue Regeneration MH - Humans MH - Male MH - Mandible MH - Molar/physiopathology MH - Molar, Third/*surgery MH - Periodontal Attachment Loss/etiology/prevention & control/therapy MH - Periodontal Diseases/etiology/*prevention & control/therapy MH - Periodontal Index MH - Postoperative Complications/etiology/*prevention & control/therapy MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Wound Healing EDAT- 2004/09/29 05:00 MHDA- 2004/12/16 09:00 CRDT- 2004/09/29 05:00 PHST- 2004/09/29 05:00 [pubmed] PHST- 2004/12/16 09:00 [medline] PHST- 2004/09/29 05:00 [entrez] AID - S0278239104008559 [pii] AID - 10.1016/j.joms.2004.06.035 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2004 Oct;62(10):1213-24. doi: 10.1016/j.joms.2004.06.035. PMID- 18272344 OWN - NLM STAT- MEDLINE DCOM- 20080731 LR - 20151119 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 37 IP - 3 DP - 2008 Mar TI - Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. PG - 264-8 LID - 10.1016/j.ijom.2007.11.011 [doi] AB - The aim of this study was to investigate the ability of serrapeptase to reduce postoperative swelling, pain and trismus after third molar surgery. Twenty-four healthy individuals with symmetrically impacted mandibular third molars underwent surgical removal in a prospective, intra-individual, randomized, double-blind, cross-over study. Teeth were removed in 2 sessions by the same surgeon. At each session, one third molar was removed under local anaesthesia via a buccal osteotomy. All patients received a combination of either serrapeptase 5mg or placebo tablets and 1000 mg paracetamol tablets at either the 1st or 2nd operation in accordance with the randomization plan. Cheek thickness, pain and interincisal distance were measured preoperatively, and on the 1st, 2nd, 3rd and 7th postoperative days. Cheek thickness and maximum interincisal distance were measured using calipers. Pain intensity was assessed clinically using a numeric scale. There was a significant reduction in the extent of cheek swelling and pain intensity in the serrapeptase group at the 2nd, 3rd and 7th postoperative days (P<0.05), but no significant difference in mean maximal interincisal distance was found between the 2 groups (P>0.05). FAU - Al-Khateeb, T H AU - Al-Khateeb TH AD - Division of Oral & Maxillofacial Surgery, Faculty of Dentistry, Jordan University of Science and Technology and King Abdulla University Hospital, Irbid, Jordan. taiseerhhk@yahoo.com FAU - Nusair, Y AU - Nusair Y LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20080212 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - EC 3.4.- (Peptide Hydrolases) RN - NL053ABE4J (serratiopeptidase) SB - D SB - IM MH - Acetaminophen/administration & dosage/therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Edema/*prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Osteotomy MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Peptide Hydrolases/administration & dosage/*therapeutic use MH - Placebos MH - *Postoperative Complications MH - Prospective Studies MH - Serratia MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Trismus/*prevention & control EDAT- 2008/02/15 09:00 MHDA- 2008/08/01 09:00 CRDT- 2008/02/15 09:00 PHST- 2007/05/05 00:00 [received] PHST- 2007/06/30 00:00 [revised] PHST- 2007/11/26 00:00 [accepted] PHST- 2008/02/15 09:00 [pubmed] PHST- 2008/08/01 09:00 [medline] PHST- 2008/02/15 09:00 [entrez] AID - S0901-5027(07)01067-3 [pii] AID - 10.1016/j.ijom.2007.11.011 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2008 Mar;37(3):264-8. doi: 10.1016/j.ijom.2007.11.011. Epub 2008 Feb 12. PMID- 3862020 OWN - NLM STAT- MEDLINE DCOM- 19851024 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 60 IP - 2 DP - 1985 Aug TI - Evaluation of methylprednisolone and flurbiprofen for inhibition of the postoperative inflammatory response. PG - 137-45 AB - The ideal anti-inflammatory agent for use in third molar surgery should control pain, reduce swelling and trismus, and have no unwanted side effects. This investigation evaluated and compared the efficacy of corticosteroids, nonsteroidal anti-inflammatory agents, and placebo for reduction of the acute postoperative inflammatory response and its undesirable sequelae in patients undergoing the surgical removal of impacted third molars. Corticosteroids appeared to have maximal effect in controlling edema but had minimal analgesic effects. Nonsteroidal anti-inflammatory agents appear to be effective analgesics. A combination of these agents may be necessary to control the sequelae of oral surgical procedures most effectively. FAU - Sisk, A L AU - Sisk AL FAU - Bonnington, G J AU - Bonnington GJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Placebos) RN - 0 (Propionates) RN - 5GRO578KLP (Flurbiprofen) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adolescent MH - Adult MH - Edema/etiology/prevention & control MH - Female MH - Flurbiprofen/*therapeutic use MH - Gingival Diseases/etiology/prevention & control MH - Humans MH - Male MH - Methylprednisolone/*therapeutic use MH - Molar, Third MH - Pain, Postoperative/prevention & control MH - Placebos MH - Propionates/*therapeutic use MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 1985/08/01 00:00 MHDA- 1985/08/01 00:01 CRDT- 1985/08/01 00:00 PHST- 1985/08/01 00:00 [pubmed] PHST- 1985/08/01 00:01 [medline] PHST- 1985/08/01 00:00 [entrez] AID - 10.1016/0030-4220(85)90281-6 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1985 Aug;60(2):137-45. doi: 10.1016/0030-4220(85)90281-6. PMID- 16188428 OWN - NLM STAT- MEDLINE DCOM- 20060504 LR - 20161124 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 35 IP - 3 DP - 2006 Mar TI - Perioperative dexamethasone reduces post-surgical sequelae of wisdom tooth removal. A split-mouth randomized double-masked clinical trial. PG - 241-6 AB - The effect of endo-alveolar and sub-mucosal administration of dexamethasone sodium phosphate to prevent inflammatory sequelae after surgical removal of lower third molars was studied. Forty-three patients underwent bilateral extractions of lower third molars and were randomly assigned to receive either dexamethasone 4 mg (group A) or 10 mg (group B) as endo-alveolar powder or 10 mg as sub-mucosal injection (group C) unilaterally. The controlateral site served as control and did not receive any steroid administration. Facial edema, trismus and pain perception were evaluated at the 2nd and 7th postoperative day. A multivariate analysis revealed that treatment and ostectomy time were both significantly positively associated with the degree of postoperative trismus and edema. Other baseline classification variables (e.g., molar classification) were also predictive of the degree of change in all clinical parameters. Test sites treated (any steroid application) showed greater reductions in all clinical parameters recorded compared to control. No statistically significant differences were observed between the three test groups. Both sub-mucosal and endo-alveolar administration of dexamethasone are effective in reducing postoperative sequelae of surgical removal of lower wisdom teeth. FAU - Graziani, F AU - Graziani F AD - Department of Neurosciences, Section of Oral Surgery, University of Pisa, Via Roma 67, 56100 Pisa, Italy. f.graziani@med.unipi.it FAU - D'Aiuto, F AU - D'Aiuto F FAU - Arduino, P G AU - Arduino PG FAU - Tonelli, M AU - Tonelli M FAU - Gabriele, M AU - Gabriele M LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20050926 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Powders) RN - 2BP70L44PR (dexamethasone 21-phosphate) RN - 7S5I7G3JQL (Dexamethasone) SB - D SB - IM MH - Adult MH - Anti-Inflammatory Agents/administration & dosage/*therapeutic use MH - Dexamethasone/administration & dosage/*analogs & derivatives/therapeutic use MH - Double-Blind Method MH - Edema/prevention & control MH - Face MH - Female MH - Follow-Up Studies MH - Humans MH - Injections MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Osteotomy/adverse effects MH - Pain Threshold/drug effects MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Powders MH - *Premedication MH - *Tooth Extraction/adverse effects MH - Trismus/prevention & control EDAT- 2005/09/29 09:00 MHDA- 2006/05/05 09:00 CRDT- 2005/09/29 09:00 PHST- 2004/11/01 00:00 [received] PHST- 2005/07/14 00:00 [accepted] PHST- 2005/09/29 09:00 [pubmed] PHST- 2006/05/05 09:00 [medline] PHST- 2005/09/29 09:00 [entrez] AID - S0901-5027(05)00245-6 [pii] AID - 10.1016/j.ijom.2005.07.010 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2006 Mar;35(3):241-6. doi: 10.1016/j.ijom.2005.07.010. Epub 2005 Sep 26. PMID- 30321520 OWN - NLM STAT- MEDLINE DCOM- 20200108 LR - 20200108 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 77 IP - 2 DP - 2019 Feb TI - Does Pre-Emptive Administration of Intravenous Ibuprofen (Caldolor) or Intravenous Acetaminophen (Ofirmev) Reduce Postoperative Pain and Subsequent Narcotic Consumption After Third Molar Surgery? PG - 262-270 LID - S0278-2391(18)31080-2 [pii] LID - 10.1016/j.joms.2018.09.010 [doi] AB - PURPOSE: Pre-emptive analgesia is known to reduce postoperative pain after third molar removal. The purpose of this study was to compare postoperative pain in patients receiving either preoperative intravenous (IV) ibuprofen or preoperative IV acetaminophen for third molar surgery. PATIENTS AND METHODS: This study was a randomized, single-blinded clinical study conducted in patients undergoing surgical extraction of 2 or more impacted third molars under deep sedation. This study compared 2 interventions: 800 mg of IV ibuprofen (Caldolor; Cumberland Pharmaceuticals, Nashville, TN) and 1,000 mg of IV acetaminophen (Ofirmev; Mallinckrodt Pharmaceuticals, Staines-upon-Thames, United Kingdom). The primary outcome variable was postoperative pain measured on a visual analog scale at different time points. The secondary outcome variable was the amount of postoperative analgesic (narcotic and over-the-counter) medication taken in both groups. The Mann-Whitney U test was used to compare groups in terms of outcomes, the χ(2) test was used to assess associations between nominal variables, and Spearman correlations were used to assess associations between continuous variables. Significance was set at P < .05. RESULTS: The study sample consisted of 58 patients (39 female and 19 male patients). A total of 41 patients (IV ibuprofen, n = 19; IV acetaminophen, n = 22) completed the study. Equal distributions of age, gender, and number of impacted teeth were noted between the groups. At 4 hours postoperatively, the pain level in the ibuprofen group was significantly lower than that in the acetaminophen group (P = .004). This trend continued at 24 hours (P = .019) and 48 hours (P = .017). The average amount of narcotic medication taken in the ibuprofen group (2.68 ± 2.26 doses) was lower than that in the acetaminophen group (7.32 ± 6.68 doses), and the result was statistically significant (P = .005). CONCLUSIONS: Pre-emptive analgesia with IV ibuprofen is more effective than IV acetaminophen in reducing postoperative pain and opioid use for third molar surgery. CI - Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Viswanath, Archana AU - Viswanath A AD - Assistant Professor and Director of Clinical Research, Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, MA. Electronic address: Archana.Viswanath@tufts.edu. FAU - Oreadi, Daniel AU - Oreadi D AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, MA. FAU - Finkelman, Matthew AU - Finkelman M AD - Associate Professor, Division of Biostatistics and Experimental Design, Tufts University School of Dental Medicine, Boston, MA. FAU - Klein, Gustavo AU - Klein G AD - Private Practice, Bauru, Brazil. FAU - Papageorge, Maria AU - Papageorge M AD - Professor and Chair, Department of Oral and Maxillofacial Surgery, Tufts University School of Dental Medicine, Boston, MA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180920 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Narcotics) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - D SB - IM MH - Acetaminophen/*therapeutic use MH - Administration, Intravenous MH - *Analgesics, Non-Narcotic MH - Analgesics, Opioid MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Molar, Third MH - Narcotics/*therapeutic use MH - Pain, Postoperative/*prevention & control EDAT- 2018/10/16 06:00 MHDA- 2020/01/09 06:00 CRDT- 2018/10/16 06:00 PHST- 2017/07/28 00:00 [received] PHST- 2018/09/10 00:00 [revised] PHST- 2018/09/10 00:00 [accepted] PHST- 2018/10/16 06:00 [pubmed] PHST- 2020/01/09 06:00 [medline] PHST- 2018/10/16 06:00 [entrez] AID - S0278-2391(18)31080-2 [pii] AID - 10.1016/j.joms.2018.09.010 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2019 Feb;77(2):262-270. doi: 10.1016/j.joms.2018.09.010. Epub 2018 Sep 20. PMID- 28161136 OWN - NLM STAT- MEDLINE DCOM- 20180319 LR - 20201209 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 46 IP - 5 DP - 2017 May TI - Efficacy of oral diclofenac with or without codeine for pain control after invasive bilateral third molar extractions. PG - 621-627 LID - S0901-5027(17)30025-5 [pii] LID - 10.1016/j.ijom.2017.01.008 [doi] AB - Postoperative pain and inflammation after oral surgery is mostly managed using non-steroidal anti-inflammatory drugs (NSAIDs). However, opioids combined with NSAIDs may improve pain management in patients, especially after traumatic oral surgery. Few studies have compared NSAIDs with and without opioid use after oral and maxillofacial surgery. This randomized, double-blind, cross-over study compared the clinical efficacy of either diclofenac (50mg) and codeine (50mg) or diclofenac alone (50mg) for the management of postoperative pain after invasive third molar surgery. Volunteers (n=46) who were scheduled to undergo the removal of symmetrically positioned lower third molars in two separate appointments were included. They reported significantly less postoperative pain at various time points within 24h after surgery and also consumed significantly less rescue medication (paracetamol (acetaminophen)) throughout the study when they took diclofenac combined with codeine than when they took only diclofenac. In conclusion, oral diclofenac with codeine was more effective for managing postoperative pain than diclofenac without codeine. It was expected that patients taking two pain medications after surgery would generally have less pain than when taking only one of the two medications. The prospective cross-over design of the present work makes this study distinct from many others. CI - Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Zupelari-Goncalves, P AU - Zupelari-Goncalves P AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Weckwerth, G M AU - Weckwerth GM AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Calvo, A M AU - Calvo AM AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Simoneti, L F AU - Simoneti LF AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Dionisio, T J AU - Dionisio TJ AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Brozoski, D T AU - Brozoski DT AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Torres, E A AU - Torres EA AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Lauris, J R P AU - Lauris JRP AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Faria, F A C AU - Faria FAC AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Santos, C F AU - Santos CF AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. Electronic address: cfsantos@fob.usp.br. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170201 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 144O8QL0L1 (Diclofenac) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Administration, Oral MH - Analgesics, Opioid/administration & dosage/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Codeine/administration & dosage/*therapeutic use MH - Cross-Over Studies MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Management MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - NSAIDs OT - codeine OT - diclofenac OT - opioids OT - oral surgery OT - pain OT - third molar EDAT- 2017/02/06 06:00 MHDA- 2018/03/20 06:00 CRDT- 2017/02/06 06:00 PHST- 2016/02/02 00:00 [received] PHST- 2016/12/12 00:00 [revised] PHST- 2017/01/09 00:00 [accepted] PHST- 2017/02/06 06:00 [pubmed] PHST- 2018/03/20 06:00 [medline] PHST- 2017/02/06 06:00 [entrez] AID - S0901-5027(17)30025-5 [pii] AID - 10.1016/j.ijom.2017.01.008 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2017 May;46(5):621-627. doi: 10.1016/j.ijom.2017.01.008. Epub 2017 Feb 1. PMID- 9882083 OWN - NLM STAT- MEDLINE DCOM- 19990415 LR - 20180612 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 38 IP - S1 DP - 1998 Dec TI - Clinical comparison of dexketoprofen trometamol and dipyrone in postoperative dental pain. PG - 55S-64S AB - A total of 125 outpatients with moderate to severe pain after surgical removal of one impacted third molar were randomly assigned to receive dexketoprofen trometamol 12.5 or 25 mg or dipyrone 575 mg. For first-dose assessments, patients rated their pain intensity and its relief at regular intervals. From 60 min post dose to the end of the 6-h observation period, both doses of dexketoprofen trometamol had higher pain relief scores than dipyrone: Between 3 and 6 h the differences were statistically significant. In addition, peak measures (PIDmax and PARmax) were statistically superior after both doses of dexketoprofen trometamol compared to dipyrone. The overall efficacy assessed at the end of the first-dose phase was rated as good or excellent by 90%, 83.3%, and 70% of patients receiving dexketoprofen trometamol 25 mg, dexketoprofen trometamol 12.5 mg, and dipyrone, respectively. The number of patients who required remedication during the 6-h period was significantly lower in both dexketoprofen groups. Repeated-dose data were also obtained. No significant differences were found in the efficacy after repeated doses, the number of doses taken, or the mean time elapsed between doses. The overall efficacy at the end of the repeated-dose phase was rated as good or excellent by 84.2%, 66.7%, and 70% of patients receiving dexketoprofen trometamol 25 mg, dexketoprofen trometamol 12.5 mg, and dipyrone, respectively. The frequency of adverse events was similar for all treatments and no serious adverse events were reported during the study. FAU - Bagán, J V AU - Bagán JV AD - Hospital General, Valencia, Spain. FAU - López Arranz, J S AU - López Arranz JS FAU - Valencia, E AU - Valencia E FAU - Santamaría, J AU - Santamaría J FAU - Eguidazu, I AU - Eguidazu I FAU - Horas, M AU - Horas M FAU - Forns, M AU - Forns M FAU - Zapata, A AU - Zapata A FAU - Artigas, R AU - Artigas R FAU - Mauleón, D AU - Mauleón D LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 023C2WHX2V (Tromethamine) RN - 6429L0L52Y (Dipyrone) RN - 90Y4QC304K (Ketoprofen) RN - N674F7L21E (dexketoprofen trometamol) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Dipyrone/adverse effects/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Ketoprofen/*analogs & derivatives/pharmacology/toxicity MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction MH - Tromethamine/*analogs & derivatives/pharmacology/toxicity EDAT- 1999/01/09 00:00 MHDA- 1999/01/09 00:01 CRDT- 1999/01/09 00:00 PHST- 1999/01/09 00:00 [pubmed] PHST- 1999/01/09 00:01 [medline] PHST- 1999/01/09 00:00 [entrez] PST - ppublish SO - J Clin Pharmacol. 1998 Dec;38(S1):55S-64S. PMID- 30088558 OWN - NLM STAT- MEDLINE DCOM- 20190207 LR - 20190215 IS - 1678-4170 (Electronic) IS - 0066-782X (Print) IS - 0066-782X (Linking) VI - 111 IP - 3 DP - 2018 Sep TI - Evaluation of the Bleeding Intensity of Patients Anticoagulated with Warfarin or Dabigatran Undergoing Dental Procedures. PG - 394-399 LID - 10.5935/abc.20180137 [doi] AB - BACKGROUND: Thrombotic disorders remain one of the leading causes of death in the Western world. Dabigatran appeared as an alternative to warfarin for anticoagulation in the treatment of atrial fibrillation (AF). The risk associated with bleeding due to its use has been documented in several randomized clinical trials, but no large study has examined in detail the risk of bleeding during dental extraction and other dental procedures involving bleeding. OBJECTIVE: To compare the intensity of bleeding in individuals taking dabigatran or vitamin K antagonist (warfarin) and undergoing dental procedures. METHODS: Prospective, single-center, controlled study with one single observer. Patients diagnosed with nonvalvular AF, on warfarin or dabigatran, cared for at a cardiology referral center, and requiring single or multiple dental extractions, were evaluated up to seven days post-extraction. The following outcomes were assessed: bleeding time between the beginning and the end of suture and complete hemostasis; bleeding before the procedure, after 24 hours, 48 hours, 7 days, during and after suture removal (late); p<0.05 was defined as of statistical relevance. RESULTS: We evaluated 37 individuals, 25 in the warfarin group and 12 in the dabigatran group. Age, sex, weight, height, blood pressure, color, schooling, family income and comorbidities were similar between the two groups. Regarding bleeding after 24 hours of the procedure, no one in the dabigatran group had bleeding, whereas 32% in the warfarin group had documented bleeding (p = 0.028). The other variables analyzed did not differ between the groups. CONCLUSIONS: This study suggests that, regarding dental extraction, there is no statistically significant difference in the intensity of bleeding of patients taking dabigatran as compared to those taking warfarin. Bleeding 24 hours after the procedure was less frequent among patients on dabigatran. FAU - Andrade, Marcus Vinicius Santos AU - Andrade MVS AD - Escola Bahiana de Medicina e Saúde Pública, Salvador, BA - Brazil. AD - Hospital Santa Izabel da Santa Casa de Misericórdia da Bahia, Salvador, BA - Brazil. AD - Centro de Referência em Doenças Cardiovasculares - Dr. Adriano Pondé, Salvador, BA - Brazil. FAU - Andrade, Luciana Azevedo Prata AU - Andrade LAP AD - Hospital Santa Izabel da Santa Casa de Misericórdia da Bahia, Salvador, BA - Brazil. AD - Centro de Referência em Doenças Cardiovasculares - Dr. Adriano Pondé, Salvador, BA - Brazil. FAU - Bispo, Alan Freitas AU - Bispo AF AD - Centro de Referência em Doenças Cardiovasculares - Dr. Adriano Pondé, Salvador, BA - Brazil. FAU - Freitas, Luana de Alencar AU - Freitas LA AD - Centro de Referência em Doenças Cardiovasculares - Dr. Adriano Pondé, Salvador, BA - Brazil. FAU - Andrade, Milena Quadros Sampaio AU - Andrade MQS AD - Escola Bahiana de Medicina e Saúde Pública, Salvador, BA - Brazil. FAU - Feitosa, Gilson Soares AU - Feitosa GS AD - Escola Bahiana de Medicina e Saúde Pública, Salvador, BA - Brazil. AD - Hospital Santa Izabel da Santa Casa de Misericórdia da Bahia, Salvador, BA - Brazil. FAU - Feitosa-Filho, Gilson Soares AU - Feitosa-Filho GS AD - Escola Bahiana de Medicina e Saúde Pública, Salvador, BA - Brazil. AD - Hospital Santa Izabel da Santa Casa de Misericórdia da Bahia, Salvador, BA - Brazil. LA - eng LA - por PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20180806 TA - Arq Bras Cardiol JT - Arquivos brasileiros de cardiologia JID - 0421031 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) RN - I0VM4M70GC (Dabigatran) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Anticoagulants/*adverse effects MH - Bleeding Time MH - *Blood Loss, Surgical MH - Dabigatran/*adverse effects MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Reference Values MH - Risk Factors MH - Statistics, Nonparametric MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Warfarin/*adverse effects PMC - PMC6173350 COIS- Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. EDAT- 2018/08/09 06:00 MHDA- 2019/02/08 06:00 CRDT- 2018/08/09 06:00 PHST- 2018/01/22 00:00 [received] PHST- 2018/04/25 00:00 [accepted] PHST- 2018/08/09 06:00 [pubmed] PHST- 2019/02/08 06:00 [medline] PHST- 2018/08/09 06:00 [entrez] AID - S0066-782X2018005010104 [pii] AID - 10.5935/abc.20180137 [doi] PST - ppublish SO - Arq Bras Cardiol. 2018 Sep;111(3):394-399. doi: 10.5935/abc.20180137. Epub 2018 Aug 6. PMID- 19888483 OWN - NLM STAT- MEDLINE DCOM- 20100126 LR - 20181201 IS - 1064-6655 (Print) IS - 1064-6655 (Linking) VI - 23 IP - 4 DP - 2009 Fall TI - Postoperative pain relief after surgical removal of impacted third molars: a single-blind, randomized, controlled study to compare levobupivacaine and mepivacaine. PG - 325-9 AB - AIM: To compare the efficacy of 0.75% levobupivacaine with that of 3% mepivacaine for pain control after surgical removal of impacted mandibular third molars. METHODS: Forty-two subjects (23 females and 19 males, mean age 23.5 +/- 4) underwent surgical removal of third molars in two separate sessions. Within each patient, levobupivacaine was used to anesthetize one extraction side and for the other side, mepivacaine. Onset of anesthesia, duration of surgery, lip numbness, timing of pain appearance and analgesic consumption were evaluated. RESULTS: There were no significant differences in onset of anesthesia, duration of surgical procedure, and lower lip numbness between the two groups (P > .05). Timing of pain appearance and of first drug consumption was significantly lower in the mepivacaine group (P < .05). Patients with levobupivacaine anesthesia had significantly lower visual analog (VAS) pain scores at 1 and 2 hours postoperatively than those with mepivacaine anesthesia. CONCLUSION: Levobupivacaine is a valid alternative to traditional local anesthetics for surgical removal of lower third molars. It presents better pain relief when compared to mepivacaine in the immediate postoperative period as evidenced by lower VAS scores. FAU - Crincoli, Vito AU - Crincoli V AD - Department of Dentistry and Surgery, University of Bari, Italy. v.crincoli@doc.uniba.it FAU - Di Bisceglie, Maria Beatrice AU - Di Bisceglie MB FAU - Massaro, Maria AU - Massaro M FAU - Giuliani, Rocco AU - Giuliani R FAU - Favia, Gianfranco AU - Favia G FAU - Brienza, Nicola AU - Brienza N LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Orofac Pain JT - Journal of orofacial pain JID - 9418507 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - A5H73K9U3W (Levobupivacaine) RN - B6E06QE59J (Mepivacaine) RN - WK2XYI10QM (Ibuprofen) RN - Y8335394RO (Bupivacaine) SB - D MH - Adult MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthetics, Local/*administration & dosage MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Bupivacaine/administration & dosage/analogs & derivatives MH - Female MH - Humans MH - Ibuprofen/therapeutic use MH - Levobupivacaine MH - Lip/drug effects MH - Male MH - Mandibular Nerve/drug effects MH - Mepivacaine/*administration & dosage MH - Molar, Third/*surgery MH - Nerve Block MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Single-Blind Method MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult EDAT- 2009/11/06 06:00 MHDA- 2010/01/27 06:00 CRDT- 2009/11/06 06:00 PHST- 2009/11/06 06:00 [entrez] PHST- 2009/11/06 06:00 [pubmed] PHST- 2010/01/27 06:00 [medline] PST - ppublish SO - J Orofac Pain. 2009 Fall;23(4):325-9. PMID- 23826643 OWN - NLM STAT- MEDLINE DCOM- 20150109 LR - 20161125 IS - 1943-3670 (Electronic) IS - 0022-3492 (Linking) VI - 85 IP - 4 DP - 2014 Apr TI - Buccal bone formation after flapless extraction: a randomized, controlled clinical trial comparing recombinant human bone morphogenetic protein 2/absorbable collagen carrier and collagen sponge alone. PG - 525-35 LID - 10.1902/jop.2013.130207 [doi] AB - BACKGROUND: Flapless extraction of teeth allows for undisturbed preservation of the nearby periosteum and a source of osteoprogenitor cells. Recombinant human bone morphogenetic protein 2 (rhBMP-2) has been used for different bone augmentation purposes with great osteoinductive capacity. The aim of this study is to compare the bone regenerative ability of rhBMP-2 on an absorbable collagen sponge (ACS) carrier to a collagen sponge (CS) alone in extraction sites with ≥50% buccal dehiscence. METHODS: Thirty-nine patients requiring extraction of a hopeless tooth with ≥50% buccal dehiscence were enrolled. After flapless extraction and randomization, either rhBMP-2/ACS carrier or CS alone was placed in the extraction site. After extraction, a baseline cone beam computed tomography (CBCT) scan was obtained of the site, and a similar scan was obtained 5 months postoperatively. Medical imaging and viewing software were used to compare the baseline and 5-month postoperative images of the study site and assess ridge width measurements, vertical height changes, and buccal plate regeneration. RESULTS: Radiographically, CBCT analysis showed that with ≥50% of buccal bone destruction, rhBMP-2/ACS was able to regenerate a portion of the lost buccal plate, maintain theoretical ridge dimensions, and allow for implant placement 5 months after extraction. The test group performed significantly (P <0.05) better in regard to clinical buccal plate regeneration (4.75 versus 1.85 mm), clinical ridge width at 5 months (6.0 versus 4.62 mm), and radiographic ridge width at 3 mm from the alveolar crest (6.17 versus 4.48 mm) after molar exclusion. There was also significantly (P <0.05) less remaining buccal dehiscence, both clinically (6.81 versus 10.0 mm) and radiographically (3.42 versus 5.16 mm), at 5 months in the test group. Significantly (P <0.05) more implants were placed in the test group without the need for additional augmentation. The mean loss in vertical ridge height (lingual/palatal) was less in the test sites but was not significantly (P = 0.514) different between the test and control groups (0.39 versus 0.64 mm). CONCLUSIONS: rhBMP-2/ACS compared to CS alone used in flapless extraction sites with a buccal dehiscence is able to regenerate lost buccal plate, maintain theoretical ridge dimensions, and allow for implant placement 5 months later. FAU - Coomes, Angela M AU - Coomes AM AD - Department of Periodontics, University of Texas Health Science Center at San Antonio Dental School, San Antonio, TX. FAU - Mealey, Brian L AU - Mealey BL FAU - Huynh-Ba, Guy AU - Huynh-Ba G FAU - Barboza-Arguello, Concepcion AU - Barboza-Arguello C FAU - Moore, William S AU - Moore WS FAU - Cochran, David L AU - Cochran DL LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130704 PL - United States TA - J Periodontol JT - Journal of periodontology JID - 8000345 RN - 0 (Bone Morphogenetic Protein 2) RN - 0 (Dental Implants) RN - 0 (Drug Carriers) RN - 0 (Recombinant Proteins) RN - 0 (Transforming Growth Factor beta) RN - 0 (recombinant human bone morphogenetic protein-2) RN - 9007-34-5 (Collagen) SB - D SB - IM MH - *Absorbable Implants MH - Adult MH - Aged MH - Alveolar Bone Loss/diagnostic imaging/surgery MH - Alveolar Process/diagnostic imaging/drug effects MH - Alveolar Ridge Augmentation/methods MH - Bone Morphogenetic Protein 2/*therapeutic use MH - Bone Regeneration/drug effects MH - Cephalometry/methods MH - *Collagen MH - Cone-Beam Computed Tomography/methods MH - Dental Implants MH - Drug Carriers MH - Female MH - Follow-Up Studies MH - Humans MH - Imaging, Three-Dimensional/methods MH - Male MH - Middle Aged MH - Osteogenesis/*drug effects MH - Recombinant Proteins/therapeutic use MH - *Tooth Extraction MH - Tooth Socket/diagnostic imaging/*drug effects/surgery MH - Transforming Growth Factor beta/*therapeutic use MH - Young Adult EDAT- 2013/07/06 06:00 MHDA- 2015/01/13 06:00 CRDT- 2013/07/06 06:00 PHST- 2013/07/06 06:00 [entrez] PHST- 2013/07/06 06:00 [pubmed] PHST- 2015/01/13 06:00 [medline] AID - 10.1902/jop.2013.130207 [doi] PST - ppublish SO - J Periodontol. 2014 Apr;85(4):525-35. doi: 10.1902/jop.2013.130207. Epub 2013 Jul 4. PMID- 23143710 OWN - NLM STAT- MEDLINE DCOM- 20150406 LR - 20210108 IS - 1865-1569 (Electronic) IS - 1865-1550 (Linking) VI - 17 IP - 4 DP - 2013 Dec TI - A prospective randomized double-blind study to assess the latency and efficacy of twin-mix and 2% lignocaine with 1:200,000 epinephrine in surgical removal of impacted mandibular third molars: a pilot study. PG - 275-80 LID - 10.1007/s10006-012-0372-3 [doi] AB - INTRODUCTION: A prospective randomized double-blind study was conducted to assess the latency and duration of pterygomandibular nerve block with a mixture of 1.8 ml 2% lignocaine with 1:200,000 epinephrine and 1 ml of 4 mg dexamethasone and its impact on postoperative sequelae of surgical extraction of impacted mandibular third molars. MATERIAL AND METHODS: The study was conducted as a prospective randomized double-blind clinical trial on 20 patients with bilateral impaction of mandibular third molars. A total of 40 interventions were included for the study, 20 with 2% lignocaine with 1:200,000 epinephrine (study group C, control) and 20 with the twin-mix (study group T, twin-mix), with a gap of 1 month between two interventions in a single patient. After injection of the anesthetic solution, the time to anesthetic effect, duration of anesthesia, and the need to re-anesthetize the surgical site were recorded. A 10-point visual analog scale (VAS) was used to assess the overall pain intensity while injecting the study drug, during surgery, and in the postoperative period. pH of the test anesthetic solutions was also determined using a pH meter. RESULTS: Twin-mix was found to be more basic than 2% lignocaine with 1:200,000 epinephrine. Mean VAS value for the pain/sting on local anesthetic injection/block was less in study group T. Time of onset of the local anesthetic was significantly less for the study group T, 51 ± 17.5 s when compared with patients in study group C (P less than 0.0001). The duration of soft tissue anesthesia was longer for all the patients in the study group T. On comparative evaluation between study group C and study group T, patients in the control group had more sever swelling and reduction in mouth opening in the postoperative period. DISCUSSION: The addition of dexamethasone to lignocaine and its administration as an intra-space injection significantly shortens the latency and prolongs the duration of the soft tissue anesthesia, with improved quality of life in the postoperative period after surgical extraction of mandibular third molars. FAU - Bhargava, Darpan AU - Bhargava D AD - Department of Oral and Maxillofacial Surgery, Peoples College of Dental Sciences, Peoples University, Bhanpur, Bhopal, (M.P), India, emaildarpan@gmail.com. FAU - Sreekumar, K AU - Sreekumar K FAU - Rastogi, Shobhit AU - Rastogi S FAU - Deshpande, Ashwini AU - Deshpande A FAU - Chakravorty, Nupur AU - Chakravorty N LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20121110 PL - Germany TA - Oral Maxillofac Surg JT - Oral and maxillofacial surgery JID - 101319632 RN - 7S5I7G3JQL (Dexamethasone) RN - 98PI200987 (Lidocaine) RN - YKH834O4BH (Epinephrine) SB - D SB - IM MH - Adult MH - Aged MH - Anesthesia, Dental/*methods MH - Antibiotic Prophylaxis MH - *Dexamethasone MH - Double-Blind Method MH - *Epinephrine MH - Female MH - Humans MH - *Lidocaine MH - Middle Aged MH - Molar, Third/*surgery MH - Nerve Block/*methods MH - Pain Measurement MH - Pain, Postoperative/diagnosis/*prevention & control MH - Pilot Projects MH - Prospective Studies MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2012/11/13 06:00 MHDA- 2015/04/07 06:00 CRDT- 2012/11/13 06:00 PHST- 2012/09/04 00:00 [received] PHST- 2012/10/29 00:00 [accepted] PHST- 2012/11/13 06:00 [entrez] PHST- 2012/11/13 06:00 [pubmed] PHST- 2015/04/07 06:00 [medline] AID - 10.1007/s10006-012-0372-3 [doi] PST - ppublish SO - Oral Maxillofac Surg. 2013 Dec;17(4):275-80. doi: 10.1007/s10006-012-0372-3. Epub 2012 Nov 10. PMID- 15218558 OWN - NLM STAT- MEDLINE DCOM- 20040722 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 62 IP - 7 DP - 2004 Jul TI - Analgesic safety and efficacy of diclofenac sodium softgels on postoperative third molar extraction pain. PG - 806-15 AB - PURPOSE: The purpose of this single-blind, placebo-controlled, 3-arm parallel, randomized study was to compare the analgesic efficacy and tolerability of a single dose of 100 mg diclofenac potassium (Cataflam; Novartis, Stein, Switzerland), 100 mg diclofenac sodium softgel, and placebo in patients experiencing moderate to severe postoperative pain after third molar extraction. PATIENTS AND METHODS: Seventy-five patients (67% female with a mean age of 23, age range 18 to 34.5 years) participated in the study following removal of at least 1 impacted mandibular third molar. Patients received a single dose of study medication when their postoperative pain reached a moderate or severe intensity. Analgesic efficacy measures included the time to meaningful pain relief measured using a stopwatch and time to rescue medication. Pain relief (PR) and Pain intensity (PI) ratings were recorded at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 8, and 24 hours postdosing. Summary analgesic measures, including Summed Pain Relief Score (TOTPAR) and Summed Pain Intensity Differences (SPID), were calculated from the 0.25- to 6-hour responses. The time between pain relief and rescue and a global evaluation for the effectiveness of the study medications were recorded at the end of the study. Seven scheduled blood samples were collected from each patient for determining plasma concentrations of diclofenac anion. RESULTS: Both diclofenac sodium softgel and Cataflam were significantly more effective than placebo (P <.0001) for all summary analgesic measures. The average overall pain relief was substantially better from diclofenac sodium softgel than from Cataflam, but the difference was not statistically significant (P =.14). In patients taking diclofenac sodium softgel, 50% of the patients experienced a time to onset of analgesic activity within 18 minutes and the median analgesic duration was 5 hours (302 minutes). Fifty percent of the patients taking Cataflam had a time to onset of action within 38 minutes, and the median duration of analgesia was 4.5 hours (272 minutes). At the time of rescue drug administration or 6 hours, whichever was earlier, 72% of the patients given diclofenac sodium softgel rated the medication as a very good or excellent pain reliever, whereas only 45% of the patients taking Cataflam gave these ratings. No serious adverse events were observed in this study. The mean concentrations of diclofenac from the diclofenac sodium softgel formulation were significantly different from the Cataflam formulation. The mean C(max) for the softgel was almost twice that of Cataflam and C(max) was reached an hour earlier, on average. CONCLUSIONS: More diclofenac anion was absorbed at a quicker rate using the formulation diclofenac sodium softgel 100 mg than Cataflam. The softgel provided a very rapid onset of analgesic activity, a prolonged analgesic duration, and an acceptable side-effect profile in the postoperative third molar surgery pain model. In an acute pain situation, the rapid absorption of nonsteroidal anti-inflammatory drugs from a formulation like the Softgel may positively affect the time of onset and duration of inflammatory pain compared with other commercially available nonsteroidal anti-inflammatory drug formulations. FAU - Zuniga, John R AU - Zuniga JR AD - Department of Oral and Maxillofacial Surgery, UNC School of Dentistry, Chapel Hill, NC 27599-7450, USA. john_zuniga@dentistry.unc.edu FAU - Phillips, Ceib L AU - Phillips CL FAU - Shugars, Daniel AU - Shugars D FAU - Lyon, James A AU - Lyon JA FAU - Peroutka, Stephen J AU - Peroutka SJ FAU - Swarbrick, James AU - Swarbrick J FAU - Bon, Charles AU - Bon C LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Capsules) RN - 0 (Placebos) RN - 144O8QL0L1 (Diclofenac) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/blood/*therapeutic use MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/blood/*therapeutic use MH - Capsules MH - Diclofenac/blood/*therapeutic use MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Patient Satisfaction MH - Placebos MH - Single-Blind Method MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2004/06/26 05:00 MHDA- 2004/07/23 05:00 CRDT- 2004/06/26 05:00 PHST- 2004/06/26 05:00 [pubmed] PHST- 2004/07/23 05:00 [medline] PHST- 2004/06/26 05:00 [entrez] AID - S0278239104002897 [pii] AID - 10.1016/j.joms.2003.12.019 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2004 Jul;62(7):806-15. doi: 10.1016/j.joms.2003.12.019. PMID- 20218866 OWN - NLM STAT- MEDLINE DCOM- 20100420 LR - 20161125 IS - 0160-6972 (Print) IS - 0160-6972 (Linking) VI - 36 IP - 1 DP - 2010 TI - Platelet rich plasma to facilitate wound healing following tooth extraction. PG - 11-23 LID - 10.1563/AAID-JOI-09-00063 [doi] AB - Following tooth removal bone formation normally takes 16 weeks and may result in less than adequate volume for the necessary reconstruction. Platelet rich plasma (PRP) has been promoted as an effective method for improving bone formation. Its use is often expensive, time consuming, or not clinically convenient for the patient and/or clinician. This study examines a simple method for obtaining a "Buffy Coat"-PRP (BC-PRP) and its effect on bone healing following the removal of bilateral mandibular 3rd molars. Subtraction digital radiography and CT scan analysis were used to track changes in radiographic density at PRP treated sites in comparison to ipsilateral non-PRP treated sites. PRP treated sites demonstrated early and significant increased radiographic density over baseline measurements following tooth removal. The greatest benefit of PRP is during the initial 2-week postoperative healing time period (P < .001). During weeks 3 though 12, BC-PRP treatment resulted in significant (P < .0001) increases in bone density compared to control, but there was no significant interaction between time and treatment (P > .05). For the entire time period (0-25 weeks) PRP treatment was significant (P < .0001) and time was significant (P < .0001) but there was no significant interaction (P > .05) between the effect of PRP treatment and time. It required 6 weeks for control extraction sites to reach comparable bone density that PRP treated sites achieved at week 1. Postoperative pain, bleeding, and numbness were not significantly affected by BC-PRP application. Results suggest that this simple technique may be of value to clinicians performing oral surgery by facilitating bone regeneration following tooth extraction. FAU - Rutkowski, James L AU - Rutkowski JL AD - Duquesne University, USA. james.rutkowski@verizon.net FAU - Johnson, David A AU - Johnson DA FAU - Radio, Nicholas M AU - Radio NM FAU - Fennell, James W AU - Fennell JW LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Implantol JT - The Journal of oral implantology JID - 7801086 SB - D MH - Adult MH - Alveolar Bone Loss/etiology/*prevention & control MH - Analysis of Variance MH - Bone Density MH - *Bone Regeneration MH - Humans MH - Mandible/diagnostic imaging MH - Molar, Third/surgery MH - *Platelet-Rich Plasma MH - Prospective Studies MH - Radiography, Dental, Digital MH - Tomography, X-Ray Computed MH - *Tooth Extraction/adverse effects MH - Tooth Socket/*physiology/surgery MH - Wound Healing MH - Young Adult EDAT- 2010/03/12 06:00 MHDA- 2010/04/21 06:00 CRDT- 2010/03/12 06:00 PHST- 2010/03/12 06:00 [entrez] PHST- 2010/03/12 06:00 [pubmed] PHST- 2010/04/21 06:00 [medline] AID - 10.1563/AAID-JOI-09-00063 [doi] PST - ppublish SO - J Oral Implantol. 2010;36(1):11-23. doi: 10.1563/AAID-JOI-09-00063. PMID- 25872465 OWN - NLM STAT- MEDLINE DCOM- 20150804 LR - 20150518 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 6 DP - 2015 Jun TI - Does laterally rotated flap design influence the short-term periodontal status of second molars and postoperative discomfort after partially impacted third molar surgery? PG - 1031-41 LID - S0278-2391(15)00059-2 [pii] LID - 10.1016/j.joms.2015.01.005 [doi] AB - PURPOSE: To assess the influence of the surgical removal of partially impacted third molars (3Ms) and compare the effects of a 3-cornered laterally rotated flap (LRF) with primary closure (flap 1) and an envelope flap with secondary closure (flap 2) on the short-term periodontal status of the adjacent second molars (2Ms). We also assessed the postoperative complications after removal of the partially impacted 3M. MATERIALS AND METHODS: A split mouth, randomized clinical study was designed. The study sample included patients with bilateral partially impacted 3Ms. The primary predictor variable was the type of flap design (flaps 1 and 2). The primary outcome variable was periodontal status (gingival recession [GR], probing depth [PD], plaque index [PI], and gingival index) of the 2Ms measured preoperatively and 90 days postoperatively. The secondary outcome variables were postoperative complications, including pain, facial swelling, alveolitis, and local wound infection. The other variables included gender, position of the 3Ms, and surgical difficulty. We performed descriptive, comparative, correlation, and multivariate analyses. RESULTS: The sample included 28 patients aged 18 to 28 years. The GR, PD, and PI values with the flap 2 design were greater than those with the flap 1 design (P < .05). Facial swelling with the flap 1 design was significantly greater than with the flap 2 design on the second postoperative day (P < .05). The pain levels with the flap 1 design were significantly greater than those with the flap 2 design on the first and second postoperative days (P < .05). According to the multivariate regression analyses, flap design was closely related to the periodontal status of the 2Ms and postoperative discomfort. CONCLUSION: The results of the present clinical study have shown that the flap design in partially impacted 3M surgery considerably influences the early periodontal health of the 2Ms and postoperative discomfort. However, although the 3-cornered LRF design might cause more pain and swelling, it could be the method of choice for partially impacted 3M surgery because of the early periodontal healing. CI - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Korkmaz, Yavuz Tolga AU - Korkmaz YT AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. Electronic address: ytkorkmaz@hotmail.com. FAU - Mollaoglu, Nur AU - Mollaoglu N AD - Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. FAU - Ozmeriç, Nurdan AU - Ozmeriç N AD - Professor, Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150120 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Dental Plaque Index MH - Dry Socket/etiology MH - Edema/etiology MH - Female MH - Follow-Up Studies MH - Gingival Recession/etiology MH - Humans MH - Male MH - Molar/*pathology MH - Molar, Third/*surgery MH - Osteotomy/methods MH - Pain, Postoperative/*etiology MH - *Periodontal Index MH - Periodontal Pocket/etiology MH - Periodontium/pathology/*surgery MH - Postoperative Complications MH - Surgical Flaps/classification/*surgery MH - Surgical Wound Infection/etiology MH - Tooth Crown/surgery MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult EDAT- 2015/04/16 06:00 MHDA- 2015/08/05 06:00 CRDT- 2015/04/16 06:00 PHST- 2014/09/30 00:00 [received] PHST- 2015/01/02 00:00 [revised] PHST- 2015/01/04 00:00 [accepted] PHST- 2015/04/16 06:00 [entrez] PHST- 2015/04/16 06:00 [pubmed] PHST- 2015/08/05 06:00 [medline] AID - S0278-2391(15)00059-2 [pii] AID - 10.1016/j.joms.2015.01.005 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Jun;73(6):1031-41. doi: 10.1016/j.joms.2015.01.005. Epub 2015 Jan 20. PMID- 9708687 OWN - NLM STAT- MEDLINE DCOM- 19981013 LR - 20201209 IS - 0909-8836 (Print) IS - 0909-8836 (Linking) VI - 106 IP - 4 DP - 1998 Aug TI - Variation in surgical trauma and baseline pain intensity: effects on assay sensitivity of an analgesic trial. PG - 844-52 AB - The aims of this study were to test the hypotheses that the type of 3rd molar removal determines baseline pain and that baseline pain influences analgesic assay sensitivity. Three groups of patients were studied: (i) 100 patients that had one fully erupted maxillary 3rd molar extracted; (ii) 95 patients that had one lower impacted 3rd molar surgically removed; and (iii) 98 patients that had two ipsilateral impacted 3rd molars surgically removed. In a randomized, double-blind fashion, the patients received (every third hour, three times) either: (i) paracetamol 1g; (ii) paracetamol 1g plus codeine 60 mg; or (iii) placebo. Baseline pain intensity (100 mm Visual Analogue Scale) was significantly lower after extraction (8 mm (2-20)) (=median (25th -75th percentile) than after surgical removal of one 3rd molar (35 mm (15-57)), which was significantly lower than pain intensity after surgical removal of two 3rd molars (49 mm (24-82)). Analgesic effects of the active test drugs were superior to placebo. Paracetamol with and without codeine could be distinguished in patients after surgical removal of one 3rd molar. In conclusion, baseline pain was related to the degree of surgical trauma, but large inter-individual variation in baseline pain intensity reduced the ability to distinguish between paracetamol with and without codeine. FAU - Breivik, E K AU - Breivik EK AD - Department of Oral Surgery and Oral Medicine, University of Oslo, Norway. ekristin@odont.uio.no FAU - Björnsson, G A AU - Björnsson GA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Eur J Oral Sci JT - European journal of oral sciences JID - 9504563 RN - 0 (Analgesics) RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Acetaminophen/administration & dosage/therapeutic use MH - Adolescent MH - Adult MH - Analgesics/administration & dosage/*therapeutic use MH - Analgesics, Non-Narcotic/administration & dosage/therapeutic use MH - Analgesics, Opioid/administration & dosage/therapeutic use MH - Codeine/administration & dosage/therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Mandible/surgery MH - Maxilla/surgery MH - Molar, Third/surgery MH - *Pain Measurement MH - Pain, Postoperative/drug therapy/*physiopathology MH - Placebos MH - Sensitivity and Specificity MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery EDAT- 1998/08/26 00:00 MHDA- 1998/08/26 00:01 CRDT- 1998/08/26 00:00 PHST- 1998/08/26 00:00 [pubmed] PHST- 1998/08/26 00:01 [medline] PHST- 1998/08/26 00:00 [entrez] AID - 10.1046/j.0909-8836.1998.eos106403.x [doi] PST - ppublish SO - Eur J Oral Sci. 1998 Aug;106(4):844-52. doi: 10.1046/j.0909-8836.1998.eos106403.x. PMID- 12680890 OWN - NLM STAT- MEDLINE DCOM- 20031110 LR - 20190513 IS - 0306-5251 (Print) IS - 1365-2125 (Electronic) IS - 0306-5251 (Linking) VI - 55 IP - 4 DP - 2003 Apr TI - A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery. PG - 405-12 AB - AIMS: To evaluate the effect of a 3-day regimen of ibuprofen 600 mg x 4 on acute postoperative swelling and pain and other inflammatory events after third molar surgery compared with a traditional regimen of paracetamol 1000 mg x 4. METHODS: A controlled, randomized, double-blind, cross-over study where 36 patients (26 females, 10 males) with mean age 23 (range 19-27) years acted as their own controls. All patients were subjected to surgical removal of bilateral third molars. After one operation the patients received tablets of ibuprofen 600 mg x 4 for 3 days. After the other operation they received an identical regimen of paracetamol 1000 mg tablets. Swelling was objectively measured (mm) with a standardized face bow and the patients scored their pain intensity (PI) on a 100-mm visual analogue scale. RESULTS: There was no statistically significant difference between paracetamol and ibuprofen treatment with respect to effect on acute postoperative swelling. Swelling after paracetamol on the third postoperative day was 1.8% less than that after ibuprofen. Mean (95% CI) difference between treatments was -0.3 (-4.7, 4.1) mm. On the sixth postoperative day swelling after ibuprofen was 2.3% less than that after paracetamol. Mean (95% CI) between treatments was 0.2 (-2.4, 2.8) mm. There was no statistically significant difference in pain intensity between the paracetamol and the ibuprofen regimen on the day of surgery. The mean (95% CI) difference between the treatments for summed pain intensity on the day of surgery (SUMPI 3.5-11) was 3.31 (-47.7, 54.3) mm. Two patients developed fibrinolysis of the blood clot (dry socket) after receiving ibuprofen while none did this after paracetamol treatment. There was no noticeable difference between treatments with respect to appearance of haematomas/ecchymoses or adverse effects which all were classified as mild to moderate. CONCLUSIONS: A 3-day regimen of ibuprofen 600 mg x 4 daily does not offer any clinical advantages compared with a traditional paracetamol regimen 1000 mg x 4 daily with respect to alleviation of acute postoperative swelling and pain after third molar surgery. FAU - Bjørnsson, G A AU - Bjørnsson GA AD - Section of Dental Pharmacology and Pharmacotherapy, University of Oslo, N-0316 Oslo, Norway. FAU - Haanaes, H R AU - Haanaes HR FAU - Skoglund, L A AU - Skoglund LA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Acetaminophen/*therapeutic use MH - Analgesics, Non-Narcotic/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Cross-Over Studies MH - Double-Blind Method MH - Edema/prevention & control MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - *Molar, Third MH - Pain, Postoperative/*prevention & control MH - Time Factors MH - Tooth Extraction MH - Tooth, Impacted/*surgery PMC - PMC1884233 EDAT- 2003/04/19 05:00 MHDA- 2003/11/11 05:00 CRDT- 2003/04/19 05:00 PHST- 2003/04/19 05:00 [pubmed] PHST- 2003/11/11 05:00 [medline] PHST- 2003/04/19 05:00 [entrez] AID - 1779 [pii] AID - 10.1046/j.1365-2125.2003.01779.x [doi] PST - ppublish SO - Br J Clin Pharmacol. 2003 Apr;55(4):405-12. doi: 10.1046/j.1365-2125.2003.01779.x. PMID- 16264388 OWN - NLM STAT- MEDLINE DCOM- 20060124 LR - 20131121 IS - 1698-6946 (Electronic) IS - 1698-4447 (Linking) VI - 10 IP - 5 DP - 2005 Nov-Dec TI - Analgesic efficacy of diclofenac versus methylprednisolone in the control of postoperative pain after surgical removal of lower third molars. PG - 432-9 AB - OBJECTIVE: To compare the analgesic efficacy of methylprednisolone (corticoid) versus diclofenac (nonsteroidal antiinflammatory-NSAID-) after surgical removal of lower third molars. STUDY DESIGN: Prospective study on 73 patients for the surgical removal of their lower third molars. These patients were separated in two groups at random: a diclofenac group and a methylprednisolone group. A record card was filled in with preoperative and postoperative epidemiological and clinic data. The pain level assessment was made on a semiquantitative and an analogical visual scales and in relation to the amount of rescue analgesics consumed. Pain levels were measured at 1, 8, 24, 48 and 72 hours. In order to make a broad study of data, BMDP program was used for statistics. RESULTS: In the pain described by patients in the analogical visual scale there were no differences between groups as a whole. There were no differences in the amount of rescue analgesics consumed. CONCLUSIONS: There is less pain in the corticoid group but not as to justify its routine use. FAU - López-Carriches, Carmen AU - López-Carriches C AD - Universidad Europea de Madrid. carmen.lopez@uem.es FAU - Martínez-González, José Maria AU - Martínez-González JM FAU - Donado-Rodríguez, Manuel AU - Donado-Rodríguez M LA - eng LA - spa PT - Journal Article PT - Randomized Controlled Trial PL - Spain TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Glucocorticoids) RN - 144O8QL0L1 (Diclofenac) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/*administration & dosage MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Chi-Square Distribution MH - Diclofenac/*administration & dosage MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Male MH - Mandible MH - Methylprednisolone/*administration & dosage MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/etiology/*prevention & control MH - Prospective Studies MH - Statistics, Nonparametric MH - *Tooth Extraction/adverse effects EDAT- 2005/11/03 09:00 MHDA- 2006/01/25 09:00 CRDT- 2005/11/03 09:00 PHST- 2005/11/03 09:00 [pubmed] PHST- 2006/01/25 09:00 [medline] PHST- 2005/11/03 09:00 [entrez] AID - 10489181 [pii] PST - ppublish SO - Med Oral Patol Oral Cir Bucal. 2005 Nov-Dec;10(5):432-9. PMID- 17113442 OWN - NLM STAT- MEDLINE DCOM- 20070130 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 64 IP - 12 DP - 2006 Dec TI - The effect of a single dose prednisolone with and without diclofenac on pain, trismus, and swelling after removal of mandibular third molars. PG - 1761-6 AB - PURPOSE: The purpose of this study was to evaluate the effect of a single intramuscular dose of prednisolone and the prednisolone-diclofenac combination on postoperative pain, trismus, and edema after the removal of third molars. PATIENTS AND METHODS: Forty-five patients who were to undergo surgical removal of lower third molars were studied. Patients were divided into 3 groups. In the first group, each patient was given 25 mg prednisolone intramuscularly immediately after surgery. In the second group, each patient was given 25 mg prednisolone and diclofenac intramuscularly immediately after surgery, and in the third group, each patient was given sterile saline solution as control group. Postoperative pain was evaluated by visual analogue scale on the day of surgery. Facial swelling and trismus were evaluated on postoperative days 2 and 7. ANOVA was used to analyze these data. RESULTS: Statistical analysis of the data indicated the prednisolone-diclofenac combination suppressed pain intensity in comparison with control (P < .05) at the 6-hour observation. Both the prednisolone and prednisolone-diclofenac combinations suppressed pain at the seventh postoperative hour in comparison with the control (P < .05). The prednisolone-diclofenac combination group also had a smaller loss of opening at postoperative days 2 and 7 in comparison with both the prednisolone and control groups (P < .05). Postoperative swelling was less in both the prednisolone and prednisolone-diclofenac combination groups, as compared with the control group (P < .05) at postoperative day 2. The prednisolone-diclofenac combination group also had a smaller swelling at postoperative day 7 in comparison with both the prednisolone and control groups (P < .05). CONCLUSION: It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures and should be used when extensive postoperative swelling of soft tissue is anticipated. FAU - Buyukkurt, M Cemil AU - Buyukkurt MC AD - Department of Oral and Maxillofacial Surgery, Ataturk University, Erzurum, Turkey. mcbuyukkurt@yahoo.com FAU - Gungormus, Metin AU - Gungormus M FAU - Kaya, Omer AU - Kaya O LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Drug Combinations) RN - 144O8QL0L1 (Diclofenac) RN - 9PHQ9Y1OLM (Prednisolone) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents/administration & dosage/*therapeutic use MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Edema/drug therapy/etiology MH - Female MH - Humans MH - Injections, Intramuscular MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy/etiology MH - Prednisolone/administration & dosage/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Trismus/drug therapy/etiology EDAT- 2006/11/23 09:00 MHDA- 2007/01/31 09:00 CRDT- 2006/11/23 09:00 PHST- 2005/03/24 00:00 [received] PHST- 2005/07/21 00:00 [revised] PHST- 2005/11/15 00:00 [accepted] PHST- 2006/11/23 09:00 [pubmed] PHST- 2007/01/31 09:00 [medline] PHST- 2006/11/23 09:00 [entrez] AID - S0278-2391(06)01401-7 [pii] AID - 10.1016/j.joms.2005.11.107 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2006 Dec;64(12):1761-6. doi: 10.1016/j.joms.2005.11.107. PMID- 818040 OWN - NLM STAT- MEDLINE DCOM- 19760802 LR - 20191028 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 5 IP - 2 DP - 1976 Apr TI - Clinical and hematological investigation of Rheumapax in surgical removal of impacted wisdom teeth from the mandible. PG - 66-70 AB - The clinical effect of Rheumapax and placebo on postoperative complications after surgical removal of the impacted mandibular third molar has been evaluated in a controlled clinical trial. The investigation included 66 patients in two treatment groups, 32 patients being given Rheumapax and 34 placebo. Hematological tests performed before and 10 days after the operation revealed no adverse reactions. There was a significant reduction of postoperative pain and trismus with Rheumapax in addition to a favorable, through nonsignificant, effect on swelling. FAU - Bystedt, H AU - Bystedt H LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - H806S4B3NS (Oxyphenbutazone) SB - D SB - IM MH - Adult MH - Chemical Phenomena MH - Chemistry MH - Clinical Trials as Topic MH - Dose-Response Relationship, Drug MH - Drug Evaluation MH - Female MH - Humans MH - Male MH - Mandible MH - Molar/*surgery MH - Oxyphenbutazone/administration & dosage/blood/*therapeutic use MH - Pain, Postoperative/*drug therapy MH - Postoperative Complications/*drug therapy MH - Time Factors MH - Tooth, Impacted/*surgery EDAT- 1976/04/01 00:00 MHDA- 1976/04/01 00:01 CRDT- 1976/04/01 00:00 PHST- 1976/04/01 00:00 [pubmed] PHST- 1976/04/01 00:01 [medline] PHST- 1976/04/01 00:00 [entrez] AID - 10.1016/s0300-9785(76)80050-6 [doi] PST - ppublish SO - Int J Oral Surg. 1976 Apr;5(2):66-70. doi: 10.1016/s0300-9785(76)80050-6. PMID- 356244 OWN - NLM STAT- MEDLINE DCOM- 19781025 LR - 20191028 IS - 0301-3847 (Print) IS - 0301-3847 (Linking) IP - 22 DP - 1978 TI - A clinical trial of the analgesic properties of Voltaren (diclofenac sodium). PG - 42-5 AB - In a double-blind comparison with placebo in 60 patients suffering from post-operative pain following the surgical removal of a third molar in the lower jaw, statistical analyses showed that Voltaren (diclofenac sodium) in a single dose of 50 mg had a significantly greater analgesic effect than placebo. The technique to be used for studies with analgesic drugs is briefly discussed. FAU - Hultin, M AU - Hultin M FAU - Olander, K J AU - Olander KJ LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Norway TA - Scand J Rheumatol Suppl JT - Scandinavian journal of rheumatology. Supplement JID - 0400360 RN - 0 (Phenylacetates) RN - 0 (Placebos) RN - 144O8QL0L1 (Diclofenac) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Clinical Trials as Topic MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Drug Evaluation MH - Female MH - Humans MH - Male MH - Middle Aged MH - Pain, Postoperative/*drug therapy MH - Phenylacetates/*therapeutic use MH - Placebos MH - Tooth, Impacted/*surgery EDAT- 1978/01/01 00:00 MHDA- 1978/01/01 00:01 CRDT- 1978/01/01 00:00 PHST- 1978/01/01 00:00 [pubmed] PHST- 1978/01/01 00:01 [medline] PHST- 1978/01/01 00:00 [entrez] AID - 10.3109/03009747809097215 [doi] PST - ppublish SO - Scand J Rheumatol Suppl. 1978;(22):42-5. doi: 10.3109/03009747809097215. PMID- 11887131 OWN - NLM STAT- MEDLINE DCOM- 20020327 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 60 IP - 3 DP - 2002 Mar TI - Remifentanil for use during conscious sedation in outpatient oral surgery. PG - 244-50; discussion 250-1 AB - PURPOSE: Remifentanil is a new, short-acting opioid that is similar pharmacodynamically to currently available opioids but differs in its pharmacokinetics. In the present study, we compared the use of remifentanil with the use of meperidine during intravenous conscious sedation for third molar surgery. PATIENTS AND METHODS: Forty patients who were scheduled for the removal of impacted third molars were randomly assigned to undergo 1 of 2 intravenous conscious sedation techniques. For both groups, 50:50 nitrous oxide oxygen were administered via nasal hood, and midazolam was titrated to Verril's sign. Twenty patients each then received either remifentanil 0.05 microgram/kg/min or meperidine 50 mg. Both patients and surgeons were blinded to the narcotic that was used. Blood pressure, heart rate, and oxygen saturation were determined before sedation and every 5 minutes during surgery. Recovery was measured using serial Trieger tests every 5 minutes after surgery. Patient and surgeon satisfaction of the quality of sedation was measured with a visual analog scale. RESULTS: Peak heart rate (91 beats/min for remifentanil vs 107 beats/min for meperidine, P <.01) and peak systolic blood pressure (131 mm Hg for remifentanil vs. 142 mm Hg for meperidine, P <.05) were significantly lower for the remifentanil group. Although there was a trend toward increased surgeon satisfaction with remifentanil (86 of 100 with remifentanil vs. 73 of 100 with meperidine), it was not found to be statistically significant. Likewise, other physiologic parameters were not found to be statistically significant. CONCLUSIONS: The lower peak heart rate and systolic blood pressure levels indicate that remifentanil may allow for less fluctuation in cardiovascular parameters. This could prove beneficial in patients with cardiovascular compromise. CI - Copyright 2002 American Association of Oral and Maxillofacial Surgeons FAU - Ganzberg, Steven AU - Ganzberg S AD - Department of Oral and Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, OH 43218-2357, USA. FAU - Pape, Richard A AU - Pape RA FAU - Beck, F Michael AU - Beck FM LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Opioid) RN - 0 (Anesthetics, Intravenous) RN - 0 (Piperidines) RN - 9E338QE28F (Meperidine) RN - P10582JYYK (Remifentanil) RN - R60L0SM5BC (Midazolam) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Ambulatory Surgical Procedures MH - Analgesics, Opioid/*administration & dosage MH - Anesthesia, Dental/*methods MH - Anesthetics, Intravenous/*administration & dosage MH - Blood Pressure/drug effects MH - Chi-Square Distribution MH - Conscious Sedation/*methods MH - Double-Blind Method MH - Female MH - Heart Rate/drug effects MH - Humans MH - Male MH - Meperidine/administration & dosage MH - Midazolam/administration & dosage MH - Molar, Third/surgery MH - Patient Satisfaction MH - Piperidines/*administration & dosage MH - Remifentanil MH - Statistics, Nonparametric MH - Surveys and Questionnaires MH - *Tooth Extraction EDAT- 2002/03/12 10:00 MHDA- 2002/03/28 10:01 CRDT- 2002/03/12 10:00 PHST- 2002/03/12 10:00 [pubmed] PHST- 2002/03/28 10:01 [medline] PHST- 2002/03/12 10:00 [entrez] AID - S0278239102334025 [pii] AID - 10.1053/joms.2002.30565 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2002 Mar;60(3):244-50; discussion 250-1. doi: 10.1053/joms.2002.30565. PMID- 23147329 OWN - NLM STAT- MEDLINE DCOM- 20140109 LR - 20121127 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 23 IP - 6 DP - 2012 Nov TI - Hemodynamic changes comparing lidocaine HCl with epinephrine and articaine HCl with epinephrine. PG - 1703-8 LID - 10.1097/SCS.0b013e31826bec3b [doi] AB - BACKGROUND: The aim of the present study was to analyze hemodynamic changes after the administration of either 2% lidocaine with epinephrine 1:100,000 (L100) or 4% articaine with epinephrine 1:200,000 (A200) in the surgical removal of symmetrically positioned lower third molars. METHODS: A prospective, randomized, double-blind, clinical trial was carried out involving 43 patients. Each patient underwent 2 surgeries on different occasions-one under local anesthesia with L100 and the other with A200. The following parameters were assessed at 4 different times: systolic, diastolic, and mean blood pressure; heart rate; oxygen saturation; rate pressure product (RPP); and pressure rate quotient (PRQ). RESULTS: No hypertensive peak was observed in systolic, diastolic, and mean blood pressure at any evaluation time. Moreover, the type of anesthetic solution did not affect diastolic blood pressure, oxygen saturation or PRQ during the surgeries. Statistically significant differences between groups were detected with regard to heart rate and RPP (P < 0.05). CONCLUSIONS: The epinephrine concentration (1:100,000 or 1:200,000) and local anesthetic solutions used (2% lidocaine or 4% articaine) influenced hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar removal. FAU - de Morais, Hécio Henrique Araújo AU - de Morais HH AD - Oral and Maxillofacial Surgery, Pernambuco School of Dentistry (FOP/UPE), Camaragibe, Pernambuco, Brazil. heciomorais@hotmail.com FAU - de Santana Santos, Thiago AU - de Santana Santos T FAU - Araújo, Fábio Andrey da Costa AU - Araújo FA FAU - Vajgel, André AU - Vajgel A FAU - de Holanda Vasconcellos, Ricardo José AU - de Holanda Vasconcellos RJ LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - 98PI200987 (Lidocaine) RN - D3SQ406G9X (Carticaine) RN - YKH834O4BH (Epinephrine) SB - D MH - Adolescent MH - Adult MH - Anesthetics, Local/administration & dosage/*pharmacology MH - Carticaine/administration & dosage/*pharmacology MH - Double-Blind Method MH - Epinephrine/administration & dosage/*pharmacology MH - Female MH - Hemodynamics/*drug effects MH - Humans MH - Lidocaine/administration & dosage/*pharmacology MH - Male MH - Molar, Third/*surgery MH - Prospective Studies MH - Tooth, Impacted/*surgery MH - Vasoconstrictor Agents/administration & dosage/*pharmacology EDAT- 2012/11/14 06:00 MHDA- 2014/01/10 06:00 CRDT- 2012/11/14 06:00 PHST- 2012/11/14 06:00 [entrez] PHST- 2012/11/14 06:00 [pubmed] PHST- 2014/01/10 06:00 [medline] AID - 10.1097/SCS.0b013e31826bec3b [doi] PST - ppublish SO - J Craniofac Surg. 2012 Nov;23(6):1703-8. doi: 10.1097/SCS.0b013e31826bec3b. PMID- 24040947 OWN - NLM STAT- MEDLINE DCOM- 20131203 LR - 20130917 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 71 IP - 10 DP - 2013 Oct TI - Infiltration anesthesia for extraction of the mandibular molars. PG - 1658.e1-5 LID - S0278-2391(13)00808-2 [pii] LID - 10.1016/j.joms.2013.06.203 [doi] AB - PURPOSE: Profound anesthesia for mandibular molars by buccal infiltration has been tried in recent years, with promising results. This prospective, randomized, single-blinded, crossover study investigated the clinical anesthetic efficacy obtained with 1:100,000 epinephrine plus 4% articaine (A100) 1.8 versus 3.6 mL as mandibular first molar buccal infiltration during removal of impacted lower third molars. MATERIALS AND METHODS: Thirty adult patients underwent removal of symmetrically positioned impacted lower third molars in 2 separate appointments. The patients randomly received mandibular buccal first molar infiltration of A100 1.8 or 3.6 mL during surgery. For assessment of anesthetic efficacy, any pain during surgery was rated using the visual analog scale. Also, the onset, duration, and total amount of anesthetic used were recorded. RESULTS: Compared with the 1.8-mL volume of A100, the 3.6-mL volume showed a statistically higher success rate (93% vs 56%). CONCLUSIONS: Infiltration in the buccal vestibule opposite the mandibular first molar by A100 3.6 mL may be a good option for extraction of mandibular third molars, with supplemental lingual anesthesia. CI - Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - El-Kholey, Khalid E AU - El-Kholey KE AD - Lecturer, Oral Surgery, Ain-Shames University Hospitals; Assistant Professor, Oral Surgery, Dentistry Program, Ibn-Sina College for Medical Studies, Jeddah, Saudi Arabia. Electronic address: Alkoley@hotmail.com. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - D3SQ406G9X (Carticaine) RN - YKH834O4BH (Epinephrine) SB - AIM SB - D SB - IM MH - Adult MH - Anesthesia, Dental/*methods MH - Anesthesia, Local/*methods MH - Anesthetics, Local/*administration & dosage MH - Carticaine/administration & dosage MH - Cross-Over Studies MH - Epinephrine/administration & dosage MH - Humans MH - Lip/drug effects/innervation MH - Mandible/surgery MH - Molar/drug effects/innervation MH - Molar, Third/*surgery MH - Mouth Mucosa/drug effects MH - Pain Measurement MH - Prospective Studies MH - Single-Blind Method MH - Time Factors MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Vasoconstrictor Agents/administration & dosage MH - Young Adult EDAT- 2013/09/18 06:00 MHDA- 2013/12/16 06:00 CRDT- 2013/09/18 06:00 PHST- 2013/01/31 00:00 [received] PHST- 2013/05/22 00:00 [revised] PHST- 2013/06/12 00:00 [accepted] PHST- 2013/09/18 06:00 [entrez] PHST- 2013/09/18 06:00 [pubmed] PHST- 2013/12/16 06:00 [medline] AID - S0278-2391(13)00808-2 [pii] AID - 10.1016/j.joms.2013.06.203 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2013 Oct;71(10):1658.e1-5. doi: 10.1016/j.joms.2013.06.203. PMID- 31157556 OWN - NLM STAT- MEDLINE DCOM- 20200803 LR - 20200803 IS - 1876-2891 (Electronic) IS - 1876-2883 (Linking) VI - 10 IP - 6 DP - 2019 Jul 10 TI - Effects of Lactobacillus reuteri-containing lozenges on healing after surgical removal of mandibular third molars: a randomised controlled trial. PG - 653-659 LID - 10.3920/BM2018.0168 [doi] AB - We investigated the effect of probiotic supplements on oral wound healing, swelling, pain and discomfort after surgical removal of mandibular third molars. A second aim was to evaluate if the intervention could influence the concentrations of oxytocin in saliva. Sixty-four consecutive volunteers (18-34 years) were enrolled to a double-blind randomised placebo-controlled trial with two parallel arms. Following surgery, the patients were asked to take three lozenges per day containing two strains of Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo for two weeks. The clinical healing and extra-oral swelling were scored two weeks post-operatively. Samples of wound exudate were cultivated for the presence of Staphylococcus aureus and β-haemolytic streptococci. Salivary oxytocin concentrations were analysed from pre- and post-surgery samples using ELISA technique. Compliance and the subjective perception of swelling, pain and discomfort were reported daily through visual analogue scales in a logbook. All patients except three completed the protocol and the postoperative course was uneventful in most cases. Minor extra-oral swellings were noted in five patients, but none required antibiotic treatment. At the 2-week follow-up, there were no significant differences in clinical wound healing index, extra-oral swelling, bacterial growth or salivary oxytocin levels between the groups. The self-reported data unveiled, however, a significantly reduced sense of swelling, in particular during the second week after surgery in the probiotic test group (P<0.05). Likewise, significantly fewer nights with disturbed sleep and fewer days with sick-leave from work were reported among the participants in the test group (P<0.05). No differences were found in the post-operative use of analgesics. In conclusion, we found no significant influence of probiotic supplements on objective wound healing after surgical extraction of impacted mandibular third molars. However, since the patients' perceived significant post-operative ameliorations, further studies are needed to explore the patient's value of the intervention. FAU - Wälivaara, D-Å AU - Wälivaara DÅ AD - Maxillofacial Unit, Halland Hospital, 30185 Halmstad, Sweden. FAU - Sjögren, I AU - Sjögren I AD - Department of Clinical Microbiology, Halland Hospital, 30185 Halmstad, Sweden. FAU - Gerasimcik, N AU - Gerasimcik N AD - Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, P.O. Box 4064, 141 04 Huddinge, Sweden. FAU - Yucel-Lindberg, T AU - Yucel-Lindberg T AD - Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, P.O. Box 4064, 141 04 Huddinge, Sweden. FAU - Twetman, S AU - Twetman S AD - Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark. FAU - Abrahamsson, P AU - Abrahamsson P AD - Maxillofacial Unit, Halland Hospital, 30185 Halmstad, Sweden. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190603 PL - Netherlands TA - Benef Microbes JT - Beneficial microbes JID - 101507616 RN - 0 (Tablets) RN - 50-56-6 (Oxytocin) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Dietary Supplements/microbiology MH - Double-Blind Method MH - Female MH - Humans MH - Lactobacillus reuteri/*physiology MH - Male MH - Molar, Third/*surgery MH - Mouth/microbiology/*pathology MH - Oxytocin/analysis MH - Pain/prevention & control MH - Probiotics/*administration & dosage MH - Saliva/chemistry/microbiology MH - Streptococcus/isolation & purification MH - Streptococcus mutans/isolation & purification MH - Tablets/administration & dosage MH - *Wound Healing MH - Young Adult OTO - NOTNLM OT - oral wound OT - oxytocin OT - probiotics OT - streptococci EDAT- 2019/06/04 06:00 MHDA- 2020/08/04 06:00 CRDT- 2019/06/04 06:00 PHST- 2019/06/04 06:00 [pubmed] PHST- 2020/08/04 06:00 [medline] PHST- 2019/06/04 06:00 [entrez] AID - 10.3920/BM2018.0168 [doi] PST - ppublish SO - Benef Microbes. 2019 Jul 10;10(6):653-659. doi: 10.3920/BM2018.0168. Epub 2019 Jun 3. PMID- 8064454 OWN - NLM STAT- MEDLINE DCOM- 19940922 LR - 20201209 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 52 IP - 9 DP - 1994 Sep TI - Analgesic efficacy of flurbiprofen in comparison with acetaminophen, acetaminophen plus codeine, and placebo after impacted third molar removal. PG - 919-24; discussion 25-6 AB - PURPOSE: The analgesic efficacy of 50 and 100 mg flurbiprofen was compared with acetaminophen 650 mg, acetaminophen 650 mg plus codeine 60 mg, and placebo. PATIENTS AND METHODS: Subjects undergoing the surgical removal of impacted third molars were randomly administered one of the five treatments after the onset of moderate to severe postoperative pain. Pain intensity, pain relief, and side effects were evaluated for 6 hours after drug administration. RESULTS: Both doses of flurbiprofen resulted in significant analgesia in comparison with placebo, acetaminophen, and acetaminophen plus codeine as measured by pain intensity difference, pain relief, and global evaluation. The greatest incidence of side effects occurred in the group receiving acetaminophen plus codeine, and the fewest side effects were reported by subjects administered flurbiprofen. CONCLUSION: The results of this study indicate that flurbiprofen is more effective and causes fewer effects than acetaminophen and codeine when used for post-operative dental pain, in ambulatory patients. FAU - Dionne, R A AU - Dionne RA AD - Clinical Pharmacology Unit, National Institute of Dental Research, Bethesda, MD. FAU - Snyder, J AU - Snyder J FAU - Hargreaves, K M AU - Hargreaves KM LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Drug Combinations) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - 5GRO578KLP (Flurbiprofen) RN - UX6OWY2V7J (Codeine) SB - AIM SB - D SB - IM MH - Acetaminophen/administration & dosage/adverse effects/*therapeutic use MH - Administration, Oral MH - Adult MH - Codeine/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Flurbiprofen/administration & dosage/adverse effects/*therapeutic use MH - Follow-Up Studies MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Placebos MH - Sleep Stages/drug effects MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery EDAT- 1994/09/01 00:00 MHDA- 1994/09/01 00:01 CRDT- 1994/09/01 00:00 PHST- 1994/09/01 00:00 [pubmed] PHST- 1994/09/01 00:01 [medline] PHST- 1994/09/01 00:00 [entrez] AID - S0278239194001175 [pii] AID - 10.1016/s0278-2391(10)80068-0 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1994 Sep;52(9):919-24; discussion 25-6. doi: 10.1016/s0278-2391(10)80068-0. PMID- 22801130 OWN - NLM STAT- MEDLINE DCOM- 20130107 LR - 20131121 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 23 IP - 4 DP - 2012 Jul TI - Hemodynamic changes comparing 2% lidocaine and 4% articaine with epinephrine 1: 100,000 in lower third molar surgery. PG - 1204-11 LID - 10.1097/SCS.0b013e31824f66a0 [doi] AB - BACKGROUND: An increase in blood pressure during dental treatment has been investigated with regard to potential medical risks since previous studies suggest that dental procedures may cause stress to the patient and, consequently, the cardiovascular system. The aim of the present study was to analyze hemodynamic changes following the administration of either 2% lidocaine (L100) or 4% articaine (A100) (both with epinephrine 1:100,000) in the surgical removal of symmetrically positioned lower third molars. METHODS: A prospective, randomized, double-blind, clinical trial was carried out involving 47 patients. Each patient underwent 1 surgery at each of 2 appointments--one under local anesthesia with L100 and the other with A100. The following parameters were assessed at 4 different times: systolic, diastolic, and mean blood pressure; heart rate; oxygen saturation; rate pressure product; and pressure rate quotient. RESULTS: No hypertensive peak was observed in systolic, diastolic, and mean blood pressure at any evaluation time. Moreover, the type of anesthetic solution did not affect diastolic blood pressure, heart rate, or oxygen saturation during the surgeries. The pressure rate quotient was the only parameter to exhibit statistically significant differences between groups at different evaluation times (P < 0.05). CONCLUSIONS: The hemodynamic parameters evaluated in third molar surgery with 2% lidocaine and 4% articaine (both with epinephrine 1:100,000) did not show significant differences. FAU - de Morais, Hécio Henrique Araújo AU - de Morais HH AD - Oral and Maxillofacial Surgery, Pernambuco School of Dentistry, Universidade de Pernambuco-Faculdade de Odontologia de Pernambuco, Camaragibe, Pernambuco, Brazil. heciomorais@hotmail.com FAU - de Santana Santos, Thiago AU - de Santana Santos T FAU - da Costa Araújo, Fábio Andrey AU - da Costa Araújo FA FAU - de Freitas Xavier, Ruth Lopes AU - de Freitas Xavier RL FAU - Vajgel, André AU - Vajgel A FAU - de Holanda Vasconcellos, Ricardo José AU - de Holanda Vasconcellos RJ LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - 98PI200987 (Lidocaine) RN - D3SQ406G9X (Carticaine) RN - YKH834O4BH (Epinephrine) SB - D MH - Adolescent MH - Adult MH - Anesthetics, Local/administration & dosage/*pharmacology MH - Carticaine/administration & dosage/*pharmacology MH - Double-Blind Method MH - Epinephrine/administration & dosage/*pharmacology MH - Female MH - Hemodynamics/*drug effects MH - Humans MH - Lidocaine/administration & dosage/*pharmacology MH - Male MH - Molar, Third/*surgery MH - Prospective Studies MH - *Tooth Extraction MH - Treatment Outcome MH - Vasoconstrictor Agents/administration & dosage/*pharmacology EDAT- 2012/07/18 06:00 MHDA- 2013/01/08 06:00 CRDT- 2012/07/18 06:00 PHST- 2012/07/18 06:00 [entrez] PHST- 2012/07/18 06:00 [pubmed] PHST- 2013/01/08 06:00 [medline] AID - 00001665-201207000-00071 [pii] AID - 10.1097/SCS.0b013e31824f66a0 [doi] PST - ppublish SO - J Craniofac Surg. 2012 Jul;23(4):1204-11. doi: 10.1097/SCS.0b013e31824f66a0. PMID- 23866780 OWN - NLM STAT- MEDLINE DCOM- 20131105 LR - 20131121 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 71 IP - 9 DP - 2013 Sep TI - Efficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo to reduce postoperative pain and swelling after surgical removal of mandibular third molars: a randomized, double-blinded, crossover clinical trial. PG - 1490-9 LID - S0278-2391(13)00487-4 [pii] LID - 10.1016/j.joms.2013.05.001 [doi] AB - PURPOSE: To compare 4 treatment combinations to reduce postoperative pain and swelling after surgical removal of mandibular third molars. PATIENTS AND METHODS: Patients scheduled for bilateral mandibular third molar removal were randomized to 1 of 4 treatment groups in a double-blinded crossover design: 1) first operation: lidocaine and placebo, second operation: bupivacaine and methylprednisolone; 2) first operation: bupivacaine and methylprednisolone, second operation: lidocaine and placebo; 3) first operation: lidocaine and methylprednisolone, second operation: bupivacaine and placebo; 4) first operation: bupivacaine and placebo, second operation: lidocaine and methylprednisolone. Patient-reported pain and swelling were recorded using visual analog scales 2, 4, 6, 8, and 12 hours after surgery and daily during the first postoperative week. The treatment effects were estimated as contrasts between the average differences within the treatment groups and assessed by stratified t tests. RESULTS: A total of 126 patients (57 women and 69 men; mean age, 25.0 years) were included in the analysis. No significant interactions between local analgesia and methylprednisolone were observed. The administration of bupivacaine resulted in less postoperative pain up to 12 hours after surgery (P < .004) and more postoperative swelling 4 to 12 hours after surgery (P < .001) compared with lidocaine. The administration of methylprednisolone resulted in less postoperative pain 4 to 12 hours and 2 days after surgery (P < .05) and less postoperative swelling 6 and 12 hours and 1 to 3 days after surgery (P < .04) compared with placebo. CONCLUSIONS: Bupivacaine combined with methylprednisolone reduced the postoperative pain and swelling compared with the use of lidocaine and placebo, lidocaine and methylprednisolone, or bupivacaine and placebo. CI - Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Christensen, Jennifer AU - Christensen J AD - Sections for Oral and Maxillofacial Surgery and Oral Pathology and Oral Radiology, Department of Dentistry, Health, Aarhus University, Aarhus, Denmark.. jennifer.heather.christensen@odontologi.au.dk FAU - Matzen, Louise Hauge AU - Matzen LH FAU - Vaeth, Michael AU - Vaeth M FAU - Wenzel, Ann AU - Wenzel A FAU - Schou, Søren AU - Schou S LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130715 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics) RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Glucocorticoids) RN - 0 (Placebos) RN - 98PI200987 (Lidocaine) RN - X4W7ZR7023 (Methylprednisolone) RN - Y8335394RO (Bupivacaine) SB - AIM SB - D SB - IM MH - Adult MH - Analgesics/therapeutic use MH - Anesthetics, Local/*administration & dosage MH - Anti-Inflammatory Agents/*therapeutic use MH - Bupivacaine/*administration & dosage MH - Cross-Over Studies MH - Double-Blind Method MH - Edema/*prevention & control MH - Female MH - Follow-Up Studies MH - Glucocorticoids/*therapeutic use MH - Humans MH - Lidocaine/*administration & dosage MH - Male MH - Mandible/surgery MH - Methylprednisolone/*therapeutic use MH - Molar, Third/*surgery MH - Operative Time MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Postoperative Complications/*prevention & control MH - Premedication MH - Surgical Flaps MH - Tooth Extraction/methods MH - Tooth, Impacted/surgery MH - Treatment Outcome EDAT- 2013/07/23 06:00 MHDA- 2013/11/06 06:00 CRDT- 2013/07/23 06:00 PHST- 2012/02/27 00:00 [received] PHST- 2013/05/03 00:00 [revised] PHST- 2013/05/05 00:00 [accepted] PHST- 2013/07/23 06:00 [entrez] PHST- 2013/07/23 06:00 [pubmed] PHST- 2013/11/06 06:00 [medline] AID - S0278-2391(13)00487-4 [pii] AID - 10.1016/j.joms.2013.05.001 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2013 Sep;71(9):1490-9. doi: 10.1016/j.joms.2013.05.001. Epub 2013 Jul 15. PMID- 8471588 OWN - NLM STAT- MEDLINE DCOM- 19930520 LR - 20201209 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 31 IP - 2 DP - 1993 Apr TI - A multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery. PG - 95-100 AB - The objectives were to compare the relative merits of ibuprofen 400 mg and dihydrocodeine 30 mg or 60 mg taken up to four times daily for up to 6 days in the treatment of pain after third molar removal. A randomised, double-blind, multiple dose, crossover study was undertaken in 68 patients undergoing two-stage bilateral lower third molar removal. The results showed that ibuprofen produced significantly greater analgesia than either of the dihydrocodeine treatments on the day of surgery. Ibuprofen and dihydrocodeine 60 mg produced significantly greater analgesia than dihydrocodeine 30 mg on the day after surgery, and on days 4 and 5 ibuprofen was again significantly superior to dihydrocodeine 60 mg. Roughly half the patients taking dihydrocodeine stopped the study on the day after surgery, because of adverse effects and/or inadequate relief, compared with 6 out of 44 taking ibuprofen. Dihydrocodeine 60 mg produced four times the number of patients affected by adverse effects compared with ibuprofen, and dihydrocodeine 30 mg three times as many. The principal adverse effects were nausea, vomiting and drowsiness. In conclusion, ibuprofen produced better analgesia than dihydrocodeine with significantly fewer adverse effects and is therefore a better choice for pain relief after oral surgery. FAU - McQuay, H J AU - McQuay HJ AD - Oxford Regional Pain Relief Unit, Churchill Hospital. FAU - Carroll, D AU - Carroll D FAU - Guest, P G AU - Guest PG FAU - Robson, S AU - Robson S FAU - Wiffen, P J AU - Wiffen PJ FAU - Juniper, R P AU - Juniper RP LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Analgesics) RN - N9I9HDB855 (dihydrocodeine) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Administration, Oral MH - Adult MH - Analgesics/administration & dosage/adverse effects/therapeutic use MH - Analysis of Variance MH - Chi-Square Distribution MH - Codeine/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use MH - Dizziness/chemically induced/etiology MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/administration & dosage/adverse effects/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Nausea/chemically induced/etiology MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Patient Compliance MH - Tooth Extraction MH - Vomiting/chemically induced/etiology EDAT- 1993/04/01 00:00 MHDA- 1993/04/01 00:01 CRDT- 1993/04/01 00:00 PHST- 1993/04/01 00:00 [pubmed] PHST- 1993/04/01 00:01 [medline] PHST- 1993/04/01 00:00 [entrez] AID - 0266-4356(93)90169-W [pii] AID - 10.1016/0266-4356(93)90169-w [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1993 Apr;31(2):95-100. doi: 10.1016/0266-4356(93)90169-w. PMID- 29072245 OWN - NLM STAT- MEDLINE DCOM- 20180528 LR - 20181202 IS - 1119-3077 (Print) VI - 20 IP - 9 DP - 2017 Sep TI - Impact of oral antibiotics on health-related quality of life after mandibular third molar surgery: An observational study. PG - 1189-1194 LID - 10.4103/1119-3077.183235 [doi] AB - AIM: To compare the impact of antibiotics on health-related quality of life (QoL) outcomes following third molar surgery. MATERIALS AND METHODS: The study population consisted of 135 subjects that required surgical extraction of mandibular third molar under local anesthesia and met the inclusion criteria. The subjects were randomized into three study groups of 45 subjects each: Group A - extended amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England), 1 gram pre-operatively and then 625 mg BD for 5 days Group B - prophylactic amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England) 1 gram pre-operatively only, and Group C - prophylactic levofloxacin 1 gram pre-operatively only. Patients were assessed pre- and post-operatively on days 1, 3, 5, 7, and 14 using the United Kingdom oral health-related QoL (OHRQoL) questionnaire. RESULTS: This study showed that surgical removal of impacted teeth exerted a negative influence on patient's QoL across various physical, social, and psychological aspects of life. Comparing the three groups, Group A showed a slightly better QoL score; although, there was no statistically significant difference among them. Studies have shown better clinical recovery following administration of antibiotics after third molar surgery. CONCLUSION: There was a significant deterioration in OHRQoL in the immediate postoperative period, particularly postoperative days 1 and 3 following third molar surgery. QoL was also observed to be slightly better in Group A than Groups B and C, although this was not statistically significant. FAU - Braimah, R O AU - Braimah RO AD - Department of Dental and Maxillofacial Surgery, Usmanu Danfodio University Teaching Hospital, Sokoto, Nigeria. FAU - Ndukwe, K C AU - Ndukwe KC AD - Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria. FAU - Owotade, J F AU - Owotade JF AD - Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria. FAU - Aregbesola, S B AU - Aregbesola SB AD - Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria. LA - eng PT - Journal Article PT - Observational Study PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 RN - 0 (Anti-Bacterial Agents) RN - 0 (beta-Lactamase Inhibitors) RN - 23521W1S24 (Clavulanic Acid) RN - 6GNT3Y5LMF (Levofloxacin) RN - 804826J2HU (Amoxicillin) SB - IM MH - Adult MH - Amoxicillin/administration & dosage/pharmacology MH - Anti-Bacterial Agents/*administration & dosage/pharmacology MH - *Antibiotic Prophylaxis/psychology MH - Clavulanic Acid/administration & dosage/pharmacology MH - Female MH - Humans MH - Levofloxacin/administration & dosage/pharmacology MH - Male MH - Molar, Third/*surgery MH - Oral Health MH - Postoperative Care MH - Preoperative Care MH - *Quality of Life MH - Surgical Wound Infection/*prevention & control MH - Surveys and Questionnaires MH - Tooth Extraction/*adverse effects/psychology MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult MH - beta-Lactamase Inhibitors/administration & dosage/pharmacology EDAT- 2017/10/27 06:00 MHDA- 2018/05/29 06:00 CRDT- 2017/10/27 06:00 PHST- 2017/10/27 06:00 [entrez] PHST- 2017/10/27 06:00 [pubmed] PHST- 2018/05/29 06:00 [medline] AID - NigerJClinPract_2017_20_9_1189_183235 [pii] AID - 10.4103/1119-3077.183235 [doi] PST - ppublish SO - Niger J Clin Pract. 2017 Sep;20(9):1189-1194. doi: 10.4103/1119-3077.183235. PMID- 19020153 OWN - NLM STAT- MEDLINE DCOM- 20081230 LR - 20131121 IS - 1526-7598 (Electronic) IS - 0003-2999 (Linking) VI - 107 IP - 6 DP - 2008 Dec TI - The analgesic efficacy and safety of a novel intranasal morphine formulation (morphine plus chitosan), immediate release oral morphine, intravenous morphine, and placebo in a postsurgical dental pain model. PG - 2018-24 LID - 10.1213/ane.0b013e318187b952 [doi] AB - BACKGROUND: Opioids are standard treatment for postoperative pain. In this study, we compared the safety and efficacy of intranasal (i.n.) morphine to i.v. and oral morphine and placebo. METHODS: Two-hundred-twenty-five patients with moderate-to-severe pain after third molar extraction were randomized to receive a single dose of i.n. morphine 7.5 mg or 15 mg, i.v. morphine 7.5 mg, oral morphine 60 mg or placebo. Pain intensity was assessed using visual analog and categorical scales, and pain relief using a categorical scale. Outcomes included total pain relief, pain intensity difference, summed pain intensity difference, time to analgesic onset, time to requesting rescue medication, and patients' global evaluation of their treatment. Safety assessments included adverse event recording and nasal examinations. RESULTS: Across the various efficacy outcomes, both i.n. morphine doses were statistically similar to the positive comparators (i.v. and oral morphine), and all four morphine treatments were statistically superior to placebo. Overall, i.n. morphine 15 mg presented an efficacy profile similar to i.v. morphine 7.5 mg; both treatments demonstrated rapid onset of efficacy, generally persistent throughout the 6-h assessment period. The lower dose of i.n. morphine, 7.5 mg, was statistically similar to the other active treatments at 2 h and 6 h and similar to placebo at 4 h. Study medications were generally well tolerated, with no withdrawals due to adverse events or other safety concerns, and no serious adverse events reported. The most frequently reported adverse events were typical systemic opioid effects. CONCLUSIONS: I.n. morphine offers a noninvasive alternative to i.v. morphine for postoperative analgesia. FAU - Christensen, Kyle S AU - Christensen KS AD - Jean Brown Associates, Salt Lake City, Utah, USA. FAU - Cohen, Amy E AU - Cohen AE FAU - Mermelstein, Fred H AU - Mermelstein FH FAU - Hamilton, Douglas A AU - Hamilton DA FAU - McNicol, Ewan AU - McNicol E FAU - Babul, Najib AU - Babul N FAU - Carr, Daniel B AU - Carr DB LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Anesth Analg JT - Anesthesia and analgesia JID - 1310650 RN - 0 (Analgesics, Opioid) RN - 76I7G6D29C (Morphine) RN - 9012-76-4 (Chitosan) SB - AIM SB - IM MH - Administration, Intranasal MH - Administration, Oral MH - Adolescent MH - Adult MH - Analgesics, Opioid/*administration & dosage MH - Chitosan/administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intravenous MH - Male MH - Morphine/*administration & dosage/adverse effects MH - Pain, Postoperative/*drug therapy MH - Toothache/*drug therapy EDAT- 2008/11/21 09:00 MHDA- 2008/12/31 09:00 CRDT- 2008/11/21 09:00 PHST- 2008/11/21 09:00 [pubmed] PHST- 2008/12/31 09:00 [medline] PHST- 2008/11/21 09:00 [entrez] AID - 107/6/2018 [pii] AID - 10.1213/ane.0b013e318187b952 [doi] PST - ppublish SO - Anesth Analg. 2008 Dec;107(6):2018-24. doi: 10.1213/ane.0b013e318187b952. PMID- 23763558 OWN - NLM STAT- MEDLINE DCOM- 20130827 LR - 20181113 IS - 0003-3006 (Print) IS - 0003-3006 (Linking) VI - 60 IP - 2 DP - 2013 Summer TI - Comparison of buccal infiltration of 4% articaine with 1 : 100,000 and 1 : 200,000 epinephrine for extraction of maxillary third molars with pericoronitis: a pilot study. PG - 42-5 LID - 10.2344/0003-3006-60.2.42 [doi] AB - We compared the buccal infiltration of 4% articaine with 1 : 100,000 or 1 : 200,000 epinephrine without a palatal injection for the extraction of impacted maxillary third molars with chronic pericoronitis. This prospective, double-blind, controlled clinical trial involved 30 patients between the ages of 15 and 46 years who desired extraction of a partially impacted upper third molar with pericoronitis. Group 1 (15 patients) received 4% articaine with 1 : 100,000 epinephrine and group 2 (15 patients) received 4% articaine with 1 : 200,000 epinephrine by buccal infiltration. None of the patients in group 1 reported pain, but 3 patients in group 2 reported pain, which indicated a need for a supplementary palatal injection. The palatal injections were all successful in eliminating the pain. Two additional patients in group 2 experienced pain when the suture needle penetrated their palatal mucosa. Based on these results, 4% articaine with 1 : 100,000 epinephrine was found to be more effective for the removal of upper third molars in the presence of pericoronitis than 4% articaine hydrochloride with 1 : 200,000 epinephrine when only a buccal infiltration was used. FAU - Lima, José Lacet Jr AU - Lima JL Jr AD - Residency Program of Oral Maxillofacial Surgery, Dental Association of Paraíba; Surgeon, Department of Oral Maxillofacial Surgery, State Emergency and Trauma Hospital, João Pessoa, PB, Brazil. FAU - Dias-Ribeiro, Eduardo AU - Dias-Ribeiro E FAU - Ferreira-Rocha, Julierme AU - Ferreira-Rocha J FAU - Soares, Ramon AU - Soares R FAU - Costa, Fábio Wildson Gurgel AU - Costa FW FAU - Fan, Song AU - Fan S FAU - Sant'ana, Eduardo AU - Sant'ana E LA - eng PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article TA - Anesth Prog JT - Anesthesia progress JID - 0043533 RN - 0 (Anesthetics, Local) RN - 0 (Vasoconstrictor Agents) RN - D3SQ406G9X (Carticaine) RN - YKH834O4BH (Epinephrine) SB - D MH - Administration, Buccal MH - Adolescent MH - Adult MH - Anesthetics, Local/*administration & dosage MH - Carticaine/*administration & dosage MH - Double-Blind Method MH - Epinephrine/*administration & dosage MH - Humans MH - Intraoperative Complications MH - Maxilla/surgery MH - Middle Aged MH - Molar, Third/*surgery MH - Needles/adverse effects MH - Pain/etiology MH - Palate/drug effects MH - Pericoronitis/complications/*surgery MH - Pilot Projects MH - Prospective Studies MH - Suture Techniques/instrumentation MH - Tooth Extraction/*methods MH - Tooth, Impacted/complications/surgery MH - Vasoconstrictor Agents/*administration & dosage MH - Young Adult PMC - PMC3683879 EDAT- 2013/06/15 06:00 MHDA- 2013/08/28 06:00 CRDT- 2013/06/15 06:00 PHST- 2013/06/15 06:00 [entrez] PHST- 2013/06/15 06:00 [pubmed] PHST- 2013/08/28 06:00 [medline] AID - 10.2344/0003-3006-60.2.42 [doi] PST - ppublish SO - Anesth Prog. 2013 Summer;60(2):42-5. doi: 10.2344/0003-3006-60.2.42. PMID- 16243241 OWN - NLM STAT- MEDLINE DCOM- 20060222 LR - 20131121 IS - 1528-395X (Electronic) IS - 1079-2104 (Linking) VI - 100 IP - 5 DP - 2005 Nov TI - Midazolam in the reduction of surgical stress: a randomized clinical trial. PG - 564-70 AB - OBJECTIVE: The objective of this study was to assess the role of midazolam in reducing surgical stress as measured using subjective and objective variables. STUDY DESIGN: The study was a double-blind randomized controlled trial. Thirty-eight male patients undergoing surgical removal of third molars under general anesthesia were recruited for this study, each patient was given premedication (midazolam or placebo) and subjective variables (HAD scale) were obtained and objective variables (salivary cortisol samples and vital signs) were collected pre-, peri-, and postoperatively. The salivary samples were analyzed by direct immunofluorimetric assay using the "DELFIA" system. RESULTS: There were no significant differences in anxiety between the treatment group and the control group before the administration of the premedication. Following the administration of premedication, the majority of the control group showed high cortisol levels on the day of surgery, compared with relatively low cortisol levels in the majority of the treatment group. A few patients in the control group gave a placebo effect (sedative effect) and a number of the treatment group were unresponsive to the drug. There was a slight drop in the blood pressure and respiration rate with a slight increase in the heart rate in the treatment group; however these results were not statistically significant. The HAD scores were not statistically different between the 2 groups. CONCLUSION: Midazolam has proved to be very successful in reducing anxiety and stress pre-, peri-, and postoperatively with no significant effect on the vital signs of a healthy patient. Salivary cortisol technique is an easy, noninvasive method to assess anxiety and stress level in patients undergoing surgery. FAU - Jerjes, Waseem AU - Jerjes W AD - Department of Oral and Maxillofacial Surgery, Eastman Dental Institute for Oral Healthcare Sciences, London, UK. waseem_wk1@yahoo.co.uk FAU - Jerjes, Walid K AU - Jerjes WK FAU - Swinson, Brian AU - Swinson B FAU - Kumar, Samintharaj AU - Kumar S FAU - Leeson, Rachel AU - Leeson R FAU - Wood, Peter J AU - Wood PJ FAU - Kattan, Meir AU - Kattan M FAU - Hopper, Colin AU - Hopper C LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Anti-Anxiety Agents) RN - 0 (Hypnotics and Sedatives) RN - R60L0SM5BC (Midazolam) RN - WI4X0X7BPJ (Hydrocortisone) SB - D SB - IM MH - Adult MH - Anti-Anxiety Agents/*therapeutic use MH - Dental Anxiety/diagnosis/etiology/*prevention & control MH - Double-Blind Method MH - Fluorescent Antibody Technique, Indirect MH - Humans MH - Hydrocortisone/analysis MH - Hypnotics and Sedatives/*therapeutic use MH - Male MH - Midazolam/*therapeutic use MH - Molar, Third/surgery MH - *Preanesthetic Medication MH - Saliva/chemistry MH - Statistics, Nonparametric MH - Stress, Psychological/diagnosis/etiology/*prevention & control MH - Tooth Extraction/adverse effects EDAT- 2005/10/26 09:00 MHDA- 2006/02/24 09:00 CRDT- 2005/10/26 09:00 PHST- 2004/11/22 00:00 [received] PHST- 2005/01/12 00:00 [revised] PHST- 2005/02/24 00:00 [accepted] PHST- 2005/10/26 09:00 [pubmed] PHST- 2006/02/24 09:00 [medline] PHST- 2005/10/26 09:00 [entrez] AID - S1079-2104(05)00264-7 [pii] AID - 10.1016/j.tripleo.2005.02.087 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Nov;100(5):564-70. doi: 10.1016/j.tripleo.2005.02.087. PMID- 8880847 OWN - NLM STAT- MEDLINE DCOM- 19970306 LR - 20190818 IS - 0304-3959 (Print) IS - 0304-3959 (Linking) VI - 66 IP - 2-3 DP - 1996 Aug TI - Ibuprofen compared with ibuprofen plus caffeine after third molar surgery. PG - 247-51 AB - OBJECTIVES: To compare the relative merits of single doses of ibuprofen and ibuprofen plus caffeine in the treatment of pain after third molar removal. DESIGN: Randomised, double-blind, placebo-controlled, single-dose parallel-group comparison of placebo, ibuprofen 200 and 400 mg with ibuprofen 200 mg plus 50, 100 or 200 mg of caffeine. SUBJECTS: 161 patients undergoing lower third molar removal. RESULTS: All active treatments produced significant analgesia and mood elevation compared with placebo. There was no significant difference in the effects of 200 and 400 mg of ibuprofen. Adding caffeine to 200 mg ibuprofen produced significantly more analgesic effect at 45 and 60 min than ibuprofen 200 mg alone. Ten patients reported 11 adverse effects, none in the highest caffeine dose group. CONCLUSIONS: Caffeine increased the analgesic effect of ibuprofen 200 mg, through an earlier onset of analgesic effect. This was achieved in this single dose context without problematic adverse effects. FAU - McQuay, H J AU - McQuay HJ AD - Oral Surgery Department, John Radcliffe Hospital, Oxford, UK. FAU - Angell, K AU - Angell K FAU - Carroll, D AU - Carroll D FAU - Moore, R A AU - Moore RA FAU - Juniper, R P AU - Juniper RP LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Central Nervous System Stimulants) RN - 0 (Drug Combinations) RN - 3G6A5W338E (Caffeine) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Caffeine/adverse effects/*therapeutic use MH - Central Nervous System Stimulants/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/adverse effects/*therapeutic use MH - Male MH - *Molar, Third MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction EDAT- 1996/08/01 00:00 MHDA- 1996/08/01 00:01 CRDT- 1996/08/01 00:00 PHST- 1996/08/01 00:00 [pubmed] PHST- 1996/08/01 00:01 [medline] PHST- 1996/08/01 00:00 [entrez] AID - 0304-3959(96)03043-6 [pii] AID - 10.1016/0304-3959(96)03043-6 [doi] PST - ppublish SO - Pain. 1996 Aug;66(2-3):247-51. doi: 10.1016/0304-3959(96)03043-6. PMID- 23352081 OWN - NLM STAT- MEDLINE DCOM- 20131105 LR - 20161125 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 41 IP - 4 DP - 2013 Jun TI - Evaluation of the effects of the use of platelet-rich plasma (PRP) on alveolar bone repair following extraction of impacted third molars: prospective study. PG - e70-5 LID - S1010-5182(12)00242-9 [pii] LID - 10.1016/j.jcms.2012.11.003 [doi] AB - Platelet-rich plasma (PRP) is rich in growth factors, target-specific polypeptides that play a role in cell proliferation and differentiation and can thus encourage wound repair. This study sought to assess the effects of PRP on new bone formation in a sample of 25 patients with clinical indications for extraction of all four impacted third molars with similar orientation, depth, and root morphology. Immediately after extraction, sockets on one side received PRP, whereas those on the other side (control) did not. Patients underwent 6 months of clinical and radiographic follow-up. Periapical radiographs were scanned and bone repair was assessed by image histogram analysis. The radiographic densities of the extraction sockets were compared to the densities of the distal surfaces of the adjacent teeth, with the difference between both serving to distinguish the PRP and control sides. Results showed that healing of PRP-treated sockets was significantly different from that of control sockets at 1-, 3-, and 6-month follow-up, in mandibular and maxillary sockets alike. The results of this sample suggest that PRP provides a safe and effective means of speeding alveolar bone repair. CI - Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Antonello, Guilherme de Marco AU - Antonello Gde M AD - Faculdade de Odontologia, Universidade Federal de Pelotas, Rua Gomes Carneiro, 1, Centro, CEP 96010-610, Pelotas, RS, Brazil. gantonello@hotmail.com FAU - Torres do Couto, Ricardo AU - Torres do Couto R FAU - Giongo, Caroline Comis AU - Giongo CC FAU - Corrêa, Marcos Britto AU - Corrêa MB FAU - Chagas Júnior, Otacílio Luiz AU - Chagas Júnior OL FAU - Lemes, Carmen Helena Jacques AU - Lemes CH LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20130124 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 RN - EC 3.4.21.5 (Thrombin) SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolar Process/diagnostic imaging/*pathology MH - Bone Density/physiology MH - Female MH - Follow-Up Studies MH - Humans MH - Image Processing, Computer-Assisted/methods MH - Male MH - Mandible/diagnostic imaging/pathology MH - Maxilla/diagnostic imaging/pathology MH - Molar, Third/*surgery MH - Osteogenesis/*physiology MH - Platelet Count MH - Platelet-Rich Plasma/*physiology MH - Prospective Studies MH - Radiography, Bitewing/methods MH - Radiography, Dental, Digital/methods MH - Thrombin/therapeutic use MH - *Tooth Extraction MH - Tooth Socket/diagnostic imaging/pathology MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2013/01/29 06:00 MHDA- 2013/11/06 06:00 CRDT- 2013/01/29 06:00 PHST- 2012/02/02 00:00 [received] PHST- 2012/11/05 00:00 [revised] PHST- 2012/11/05 00:00 [accepted] PHST- 2013/01/29 06:00 [entrez] PHST- 2013/01/29 06:00 [pubmed] PHST- 2013/11/06 06:00 [medline] AID - S1010-5182(12)00242-9 [pii] AID - 10.1016/j.jcms.2012.11.003 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2013 Jun;41(4):e70-5. doi: 10.1016/j.jcms.2012.11.003. Epub 2013 Jan 24. PMID- 7838460 OWN - NLM STAT- MEDLINE DCOM- 19950302 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 78 IP - 5 DP - 1994 Nov TI - Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery. PG - 557-66 AB - OBJECTIVE: This study compares the effectiveness of tiaprofenic acid with diclophenac sodium over a 7-day period with respect to pain, facial swelling, and trismus. STUDY DESIGN: Sixty patients who required general anesthesia for removal of bilateral impacted third molar teeth were included. Intraoperatively, they received intramuscular injections of either tiaprofenic acid or diclophenac sodium followed respectively by tiaprofenic acid tablets for 5 days and placebo for an additional 2 days or diclophenac sodium tablets for the full 7 days. Surgical and anesthetic techniques were standardized. Pain levels were compared hourly for 4 hours postoperatively and thereafter twice daily for 7 days. Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively. RESULTS: No statistically significant difference was found between the two treatment groups with respect to pain or facial swelling. Only with respect to recovery in mouth-opening ability (trismus) from day 2 to day 7 did diclophenac sodium reveal a statistically significant advantage (p = 0.0452). FAU - van der Westhuijzen, A J AU - van der Westhuijzen AJ AD - Department of Maxillofacial and Oral Surgery, Faculty of Dentistry, University of Stellenbosch, South Africa. FAU - Roelofse, J A AU - Roelofse JA FAU - Grotepass, F W AU - Grotepass FW FAU - Becker, P J AU - Becker PJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Propionates) RN - 144O8QL0L1 (Diclofenac) RN - 1LS1T6R34C (tiaprofenic acid) SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Aged MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Edema/drug therapy/prevention & control MH - Female MH - Humans MH - Inflammation/drug therapy/prevention & control MH - Injections, Intramuscular MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/drug therapy/prevention & control MH - Propionates/administration & dosage/*therapeutic use MH - Statistics, Nonparametric MH - Time Factors MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Trismus/drug therapy/prevention & control EDAT- 1994/11/01 00:00 MHDA- 1994/11/01 00:01 CRDT- 1994/11/01 00:00 PHST- 1994/11/01 00:00 [pubmed] PHST- 1994/11/01 00:01 [medline] PHST- 1994/11/01 00:00 [entrez] AID - 10.1016/0030-4220(94)90165-1 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1994 Nov;78(5):557-66. doi: 10.1016/0030-4220(94)90165-1. PMID- 23059927 OWN - NLM STAT- MEDLINE DCOM- 20130708 LR - 20181202 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 13 IP - 3 DP - 2012 TI - Should acetylsalicylic acid (ASA) therapy for prevention of thromboembolic events be stopped prior to surgical extractions? PG - 89-90 LID - 10.1038/sj.ebd.6400881 [doi] AB - DESIGN: Randomised controlled trial. INTERVENTION: Patients with coronary artery disease who were receiving 100 mg/day of ASA for the prevention of thromboembolic events, and requiring at least one molar tooth extracted were randomised to either having their ASA therapy suspended for seven days before tooth extraction and restarted the day following the surgical procedure or not having their ASA therapy suspended at any point before or after the procedure. A single dentist who was unaware of the patients' ASA therapy status performed all the extractions. OUTCOME MEASURE: Outcomes were a platelet aggregation test carried out on the day of the operation and the amount of bleeding measured during the intra-operative period. RESULTS: Bleeding was controlled with local haemostatic methods and there were no reported episodes of haemorrhaging during the intra- and post-operative periods. The mean (±SD) volume of bleeding was 12.10 ±9.37 mL for patients who underwent ASA therapy suspension and 16.38±13.54 mL for those patients whose treatments were unaltered (P= .151). The platelet reactivity index values exhibited statistically significant differences between the two investigated groups (P= .004). The platelet reactivity index values for the group with ASA therapy suspended was 242.58 ± 71.26 compared with 192.09 ± 60.54 in the group that continued with ASA. CONCLUSIONS: There was no difference in the amount of bleeding that occurred during tooth extraction between patients who continued ASA therapy and patients who suspended their ASA therapy. The platelet reactivity test demonstrated a reduction in platelet aggregation in the ASA therapy group, but this was without clinical consequence. FAU - Dodson, Tom AU - Dodson T AD - Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA, USA. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Platelet Aggregation Inhibitors) RN - R16CO5Y76E (Aspirin) SB - D SB - IM CON - J Oral Maxillofac Surg. 2011 Dec;69(12):2949-55. PMID: 21802823 MH - Aspirin/*administration & dosage MH - *Blood Loss, Surgical MH - Coronary Disease/*drug therapy MH - Female MH - Humans MH - Male MH - Platelet Aggregation Inhibitors/*administration & dosage MH - *Tooth Extraction EDAT- 2012/10/13 06:00 MHDA- 2013/07/09 06:00 CRDT- 2012/10/13 06:00 PHST- 2012/10/13 06:00 [entrez] PHST- 2012/10/13 06:00 [pubmed] PHST- 2013/07/09 06:00 [medline] AID - 6400881 [pii] AID - 10.1038/sj.ebd.6400881 [doi] PST - ppublish SO - Evid Based Dent. 2012;13(3):89-90. doi: 10.1038/sj.ebd.6400881. PMID- 355965 OWN - NLM STAT- MEDLINE DCOM- 19781027 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 45 IP - 6 DP - 1978 Jun TI - Evaluation of preoperative ibuprofen for postoperative pain after removal of third molars. PG - 851-6 AB - An evaluation of the analgesic effects of preoperatively administered ibuprofen on prospective pain after the surgical removal of impacted third molar was undertaken in 100 patients in a double-blind parallel treatment trial. The pretreatment with ibuprofen delayed the mean time of onset of postoperative pain more than 100 minutes, as compared to pretreatment with placebo. The severity of pain initially experienced postoperatively was less in the pretreated group. There was no detectable interaction between the pretreatment and the analgesics administered postoperatively. The results of this study suggest that it is possible to delay the onset and lessen the severity of postoperative pain by preoperative administration of a nonsteroidal, antiinflammatory analgesic, such as ibuprofen. FAU - Dionne, R A AU - Dionne RA FAU - Cooper, S A AU - Cooper SA LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Placebos) RN - R16CO5Y76E (Aspirin) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adolescent MH - Adult MH - Aspirin/therapeutic use MH - Clinical Trials as Topic MH - Double-Blind Method MH - Drug Evaluation MH - Drug Interactions MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Middle Aged MH - Molar/*surgery MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Preoperative Care MH - Surgical Procedures, Operative MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1978/06/01 00:00 MHDA- 1978/06/01 00:01 CRDT- 1978/06/01 00:00 PHST- 1978/06/01 00:00 [pubmed] PHST- 1978/06/01 00:01 [medline] PHST- 1978/06/01 00:00 [entrez] AID - 10.1016/s0030-4220(78)80004-8 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1978 Jun;45(6):851-6. doi: 10.1016/s0030-4220(78)80004-8. PMID- 21256649 OWN - NLM STAT- MEDLINE DCOM- 20110726 LR - 20151119 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 5 DP - 2011 May TI - Nicotine nasal spray as an adjuvant analgesic for third molar surgery. PG - 1316-9 LID - 10.1016/j.joms.2010.07.025 [doi] AB - PURPOSE: To determine the efficacy of preoperatively administered nicotine nasal spray (3 mg) for analgesia after third molar (TM) surgery. MATERIALS AND METHODS: A single-center, prospective, randomized, double-blind, crossover trial was conducted. The study population consisted of 20 nonsmoking patients referred to the Department of Oral and Maxillofacial Surgery of Columbia University College of Dental Medicine for extraction of all 4 TMs. Each patient received nicotine nasal spray or placebo spray before TM surgery. At a subsequent visit the contralateral TMs were removed with prior administration of the alternate treatment. For an hour postoperatively, subjects reported information on pain and nausea, and hemodynamic variables were recorded at 15-minute intervals. Telephone follow-up was recorded for 5 days postoperatively, where patients reported information on pain, nausea, and use of hydrocodone/acetaminophen as rescue analgesia. RESULTS: Nicotine treatment was associated with a highly significant decrease in pain reported during the 5 days after TM surgery. There was no difference in the amount of hydrocodone/acetaminophen used or amount of nausea reported. There was a small but significant increase in heart rate after nicotine treatment compared with placebo during the first hour after surgery. There was no difference in blood pressure between groups. CONCLUSION: Pain is well controlled by hydrocodone/acetaminophen in most patients after TM surgery. However, there is significant variability in pain reported. Nicotinic agonists represent a new class of analgesic that can be considered for patients who are expected to have significant opioid-resistant pain after TM surgery. Caution should be used with patients in whom a small increase in heart rate would be deleterious. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Yagoubian, Benjamin AU - Yagoubian B AD - Department of Oral and Maxillofacial Surgery, College of Dental Medicine, Columbia University, New York, NY 10032, USA. Yagoubian@me.com FAU - Akkara, Joseph AU - Akkara J FAU - Afzali, Payam AU - Afzali P FAU - Alfi, David M AU - Alfi DM FAU - Olson, Luke AU - Olson L FAU - Conell-Price, Jessamyn AU - Conell-Price J FAU - Yeh, Janet AU - Yeh J FAU - Eisig, Sidney B AU - Eisig SB FAU - Flood, Pamela AU - Flood P LA - eng GR - R21 AT004708/AT/NCCIH NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural DEP - 20110121 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics) RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Ganglionic Stimulants) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - 6M3C89ZY6R (Nicotine) RN - 6YKS4Y3WQ7 (Hydrocodone) SB - AIM SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Administration, Intranasal MH - Adolescent MH - Adult MH - Analgesics/administration & dosage/*therapeutic use MH - Analgesics, Non-Narcotic/therapeutic use MH - Analgesics, Opioid/therapeutic use MH - Blood Pressure/drug effects MH - Cross-Over Studies MH - Double-Blind Method MH - Female MH - Follow-Up Studies MH - Ganglionic Stimulants/*therapeutic use MH - Heart Rate/drug effects MH - Humans MH - Hydrocodone/therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Nicotine/administration & dosage/*therapeutic use MH - Pain, Postoperative/prevention & control MH - Placebos MH - Postoperative Nausea and Vomiting/prevention & control MH - *Premedication MH - Prospective Studies MH - Treatment Outcome MH - Young Adult EDAT- 2011/01/25 06:00 MHDA- 2011/07/27 06:00 CRDT- 2011/01/25 06:00 PHST- 2010/03/01 00:00 [received] PHST- 2010/06/16 00:00 [revised] PHST- 2010/07/03 00:00 [accepted] PHST- 2011/01/25 06:00 [entrez] PHST- 2011/01/25 06:00 [pubmed] PHST- 2011/07/27 06:00 [medline] AID - S0278-2391(10)01056-6 [pii] AID - 10.1016/j.joms.2010.07.025 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 May;69(5):1316-9. doi: 10.1016/j.joms.2010.07.025. Epub 2011 Jan 21. PMID- 21778014 OWN - NLM STAT- MEDLINE DCOM- 20120227 LR - 20161125 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 70 IP - 1 DP - 2012 Jan TI - Comparative radiographic evaluation of alveolar bone healing associated with autologous platelet-rich plasma after impacted mandibular third molar surgery. PG - 19-24 LID - 10.1016/j.joms.2011.03.028 [doi] AB - PURPOSE: This study radiographically evaluated the performance of autologous platelet-rich plasma (PRP) applied in tooth sockets. PATIENTS AND METHODS: Thirty extractions of bilateral impacted mandibular third molars were performed in 15 volunteers (7 men, 8 women; 18 to 22 years old). After extraction of right and left mandibular third molars, the socket at 1 side received the autologous PRP (PRP group) and the other was filled with blood clot (control group). Millimeter periapical radiographs were obtained 7 days, 1 month, and 2, 3, and 6 months postoperatively. Radiographic bone density was quantified 3 times by the same examiner at different moments using HLImage 97 software, and data were statistically analyzed by Statgraf 7.0 software (analysis of variance and Tukey test). RESULTS: In general, there was significantly faster bone formation in sockets treated with PRP (P < .01). Significant bone formation was observed in the first month (P < .01), second month (P < .05), and third month (P < .01) for the PRP group. No statistical differences were observed on the seventh day and sixth month of investigation, yet there were higher means of radiographic bone density in sockets treated with PRP. In the control group, men exhibited significant bone repair compared with women (P < .05). CONCLUSION: Autologous PRP was found to accelerate alveolar bone regeneration, and men presented better repair after tooth extraction. CI - Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Célio-Mariano, Ronaldo AU - Célio-Mariano R AD - Department of Clinic and Surgery, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil. mariano.int@efoa.br FAU - de Melo, Willian Morais AU - de Melo WM FAU - Carneiro-Avelino, Cássia AU - Carneiro-Avelino C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20110720 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adolescent MH - Alveolar Process/*diagnostic imaging/physiopathology MH - Blood Coagulation/physiology MH - Bone Density/physiology MH - Bone Regeneration/physiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/diagnostic imaging/*surgery MH - Molar, Third/*surgery MH - Osteogenesis/physiology MH - Platelet-Rich Plasma/*physiology MH - Radiography, Bitewing MH - Sex Factors MH - Surgical Flaps MH - Suture Techniques MH - Tooth Socket/physiopathology/surgery MH - Tooth, Impacted/*surgery MH - Transplantation, Autologous MH - Wound Healing/physiology MH - Young Adult EDAT- 2011/07/23 06:00 MHDA- 2012/03/01 06:00 CRDT- 2011/07/23 06:00 PHST- 2005/12/13 00:00 [received] PHST- 2011/03/28 00:00 [revised] PHST- 2011/03/28 00:00 [accepted] PHST- 2011/07/23 06:00 [entrez] PHST- 2011/07/23 06:00 [pubmed] PHST- 2012/03/01 06:00 [medline] AID - S0278-2391(11)00567-2 [pii] AID - 10.1016/j.joms.2011.03.028 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2012 Jan;70(1):19-24. doi: 10.1016/j.joms.2011.03.028. Epub 2011 Jul 20. PMID- 17656294 OWN - NLM STAT- MEDLINE DCOM- 20070907 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 65 IP - 8 DP - 2007 Aug TI - Tramadol administered in a combination of routes for reducing pain after removal of an impacted mandibular third molar. PG - 1633-9 FAU - Pozos, Amaury J AU - Pozos AJ AD - Department of Oral and Maxillofacial Surgery, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. apozos@uaslp.mx FAU - Martínez, Ricardo AU - Martínez R FAU - Aguirre, Patricia AU - Aguirre P FAU - Pérez, José AU - Pérez J LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Opioid) RN - 39J1LGJ30J (Tramadol) SB - AIM SB - D SB - IM MH - Adult MH - Analgesics, Opioid/*administration & dosage/blood/pharmacokinetics MH - Anesthesia, Local MH - Area Under Curve MH - Double-Blind Method MH - Drug Administration Schedule MH - Female MH - Humans MH - Injections, Intralesional MH - Injections, Intramuscular MH - Male MH - Mandible/surgery MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy/prevention & control MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/*surgery MH - Tramadol/*administration & dosage/blood/pharmacokinetics EDAT- 2007/07/28 09:00 MHDA- 2007/09/08 09:00 CRDT- 2007/07/28 09:00 PHST- 2005/09/12 00:00 [received] PHST- 2005/11/26 00:00 [revised] PHST- 2006/06/09 00:00 [accepted] PHST- 2007/07/28 09:00 [pubmed] PHST- 2007/09/08 09:00 [medline] PHST- 2007/07/28 09:00 [entrez] AID - S0278-2391(06)01200-6 [pii] AID - 10.1016/j.joms.2006.06.267 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2007 Aug;65(8):1633-9. doi: 10.1016/j.joms.2006.06.267. PMID- 22677735 OWN - NLM STAT- MEDLINE DCOM- 20130429 LR - 20131121 IS - 2212-4411 (Electronic) VI - 113 IP - 2 DP - 2012 Feb TI - Improved sedation for dental extraction by using video eyewear in conjunction with nitrous oxide: a randomized, controlled, cross-over clinical trial. PG - 188-92 LID - 10.1016/j.tripleo.2011.02.001 [doi] AB - OBJECTIVE: The purpose of this study was to investigate the effect of a portable video eyewear entertainment system used in conjunction with nitrous oxide/oxygen sedation during the removal of impacted lower third molars. STUDY DESIGN: Thirty-eight patients had their bilateral third molars removed under local anesthesia and nitrous oxide/oxygen inhalation sedation in 2 visits. On one side, video eyewear was used (group NE). On the other side, the tooth was removed without the use of video eyewear (group N). Vital signs were monitored. Overall behavior and the outcome of treatment were assessed. RESULTS: All 38 patients completed the study. The mean scores on behavior rating in group NE were significantly higher than those in group N (P < .05). The majority of patients (92.1%) preferred nitrous oxide with video eyewear. CONCLUSIONS: The use of video eyewear appeared to augment the effectiveness of nitrous oxide sedation in dental extraction patients. CI - Copyright © 2012 Elsevier Inc. All rights reserved. FAU - Zhang, Guoliang AU - Zhang G AD - Department of Anesthesia, School of Stomatology, Fourth Military Medical University, Xi'an, China. FAU - Hou, Rui AU - Hou R FAU - Zhou, Hongzhi AU - Zhou H FAU - Kong, Liang AU - Kong L FAU - Ding, Yuxiang AU - Ding Y FAU - Qin, Ruifeng AU - Qin R FAU - Hu, Kaijin AU - Hu K FAU - Xu, Jie AU - Xu J FAU - He, Jie AU - He J LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20110420 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - 0 (Anesthetics, Inhalation) RN - 0 (Hypnotics and Sedatives) RN - K50XQU1029 (Nitrous Oxide) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/*instrumentation/methods/psychology MH - Anesthetics, Inhalation/therapeutic use MH - Attention MH - Combined Modality Therapy MH - Cross-Over Studies MH - *Eyeglasses MH - Female MH - Humans MH - Hypnotics and Sedatives/*therapeutic use MH - Male MH - Molar, Third MH - Nitrous Oxide/*therapeutic use MH - Photic Stimulation/methods MH - Relaxation Therapy/psychology MH - Tooth Extraction/*methods/psychology MH - Treatment Outcome MH - *Video Recording MH - Young Adult EDAT- 2012/06/09 06:00 MHDA- 2013/04/30 06:00 CRDT- 2012/06/09 06:00 PHST- 2010/11/23 00:00 [received] PHST- 2011/01/28 00:00 [revised] PHST- 2011/02/01 00:00 [accepted] PHST- 2012/06/09 06:00 [entrez] PHST- 2012/06/09 06:00 [pubmed] PHST- 2013/04/30 06:00 [medline] AID - S1079-2104(11)00071-0 [pii] AID - 10.1016/j.tripleo.2011.02.001 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Feb;113(2):188-92. doi: 10.1016/j.tripleo.2011.02.001. Epub 2011 Apr 20. PMID- 10319823 OWN - NLM STAT- MEDLINE DCOM- 19990524 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 57 IP - 5 DP - 1999 May TI - Bupivacaine versus lidocaine for third molar surgery: a double-blind, randomized, crossover study. PG - 510-4; discussion 515 AB - PURPOSE: The aim of this study was to compare the clinical use of bupivacaine to lidocaine in third molar surgery. PATIENTS AND METHODS: Twenty-three subjects underwent surgical removal of their third molars in two separate procedures. Bupivacaine was used for the third molars on one side, whereas lidocaine was used on the other side. Pain experience, analgesic consumption, cardiovascular response, blood concentrations, and systemic toxicity were evaluated. RESULTS: Bupivacaine significantly reduced the postoperative pain experience only at the 8-hour period (P < .05). No difference in analgesic requirements or cardiovascular responses was observed with the two local anesthetics. The mean blood concentrations of both agents were considerably lower than their respective toxic threshold concentrations. CONCLUSION: The results of this study do not show a difference in a variety of parameters, other than postoperative pain experience, when bupivacaine and lidocaine are compared in a standardized oral surgery procedure. FAU - Bouloux, G F AU - Bouloux GF AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Sydney, Australia. gboulou@emory.edu FAU - Punnia-Moorthy, A AU - Punnia-Moorthy A LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics) RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) RN - Y8335394RO (Bupivacaine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesics/therapeutic use MH - Anesthesia, Dental MH - Anesthetics, Local/*administration & dosage/adverse effects/blood MH - Blood Pressure/drug effects MH - Bupivacaine/*administration & dosage/adverse effects/blood MH - Cross-Over Studies MH - Double-Blind Method MH - Elective Surgical Procedures MH - Female MH - Heart Rate/drug effects MH - Humans MH - Lidocaine/*administration & dosage/adverse effects/blood MH - Male MH - Molar, Third/*surgery MH - Nerve Block MH - Pain, Postoperative/drug therapy/prevention & control MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1999/05/13 00:00 MHDA- 1999/05/13 00:01 CRDT- 1999/05/13 00:00 PHST- 1999/05/13 00:00 [pubmed] PHST- 1999/05/13 00:01 [medline] PHST- 1999/05/13 00:00 [entrez] AID - S0278-2391(99)90063-0 [pii] AID - 10.1016/s0278-2391(99)90063-0 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1999 May;57(5):510-4; discussion 515. doi: 10.1016/s0278-2391(99)90063-0. PMID- 12598885 OWN - NLM STAT- MEDLINE DCOM- 20030527 LR - 20131121 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 194 IP - 3 DP - 2003 Feb 8 TI - An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery. PG - 153-7; discussion 149 AB - OBJECTIVE: To compare the efficacy of soluble aspirin 900 mg and paracetamol 1,000 mg in patients with postoperative pain after third molar surgery. DESIGN: A randomised, placebo controlled, double-blind study. SETTING: Day stay units of Oral and Maxillofacial Surgery at Cardiff Dental Hospital and Hexham General Hospital, Northumberland. SUBJECTS AND METHODS: One hundred and sixty-seven (104 female) patients who required the removal of their impacted third molars under general anaesthesia. INTERVENTION: In the early postoperative period, patients were medicated with either a single dose of soluble aspirin 900 mg, solid paracetamol 1,000 mg or placebo. MAIN OUTCOME MEASURES: Pain intensity was measured on 100 mm visual analogue scales at 0, 5, 10, 15, 20, 30, 45, 60, 90, 120 and 240 minutes after dosing. Other efficacy variables evaluated included time to rescue medication and an overall assessment of the study medication efficacy by the patient on completion of the study. RESULTS: One hundred and sixty-seven patients consented to take part in the study, but only 153 were medicated. Of the 14 patients not treated, 10 failed to develop sufficient pain to enter the study, two withdrew consent, one had an adverse reaction to the general anaesthetic and one was a protocol violator. Over the four hour investigation period, patients treated with soluble aspirin reported significantly less pain when compared with those treated with paracetamol (mean difference in AUC(0-240) = -2001, 95% CI -3893 to -109, p=0.038) and placebo (mean difference in AUC(0-240) = -3470, 95% CI -5719 to -1221, p=0.003). Similarly, at 20 and 30 minutes after dosing, patients in the soluble aspirin group were reporting significantly less pain than those in the paracetamol treatment group (mean difference in pain intensity: at 20 minutes -7.9, 95% CI -15.3 to -0.6, p=0.035; at 30 minutes -10.6, 95% CI -18.6 to -2.6, p=0.010). There were no significant differences between treatment groups with respect to the number of patients requiring rescue medication, however the time to dosing was significantly longer for those taking soluble aspirin when compared with placebo (hazard ratio 2.34, 95% CI 1.41 to 3.88, p<0.001). CONCLUSION: The findings from this study showed that soluble aspirin 900 mg provides significant and more rapid analgesia than paracetamol 1,000 mg in the early postoperative period after third molar surgery. FAU - Seymour, R A AU - Seymour RA AD - Department of Restorative Dentistry, Dental School, University of Newcastle, Newcastle upon Tyne, England. R. A. Seymour@ncl.ac.uk FAU - Hawkesford, J E AU - Hawkesford JE FAU - Sykes, J AU - Sykes J FAU - Stillings, M AU - Stillings M FAU - Hill, C M AU - Hill CM LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/*therapeutic use MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Area Under Curve MH - Aspirin/administration & dosage/*therapeutic use MH - Confidence Intervals MH - Double-Blind Method MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Molar, Third/*surgery MH - Odds Ratio MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Placebos MH - Solubility MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome EDAT- 2003/02/25 04:00 MHDA- 2003/05/28 05:00 CRDT- 2003/02/25 04:00 PHST- 2002/03/08 00:00 [received] PHST- 2002/09/06 00:00 [accepted] PHST- 2003/02/25 04:00 [pubmed] PHST- 2003/05/28 05:00 [medline] PHST- 2003/02/25 04:00 [entrez] AID - 4809898 [pii] AID - 10.1038/sj.bdj.4809898 [doi] PST - ppublish SO - Br Dent J. 2003 Feb 8;194(3):153-7; discussion 149. doi: 10.1038/sj.bdj.4809898. PMID- 23920075 OWN - NLM STAT- MEDLINE DCOM- 20140220 LR - 20151119 IS - 1488-2159 (Electronic) IS - 0709-8936 (Linking) VI - 79 DP - 2013 TI - Implications of Dabigatran, a direct thrombin inhibitor, for oral surgery practice. PG - d74 AB - Direct thrombin inhibitors, specifically orally administered dabigatran etexilate, are emerging as alternatives to warfarin for anticoagulation in the management of atrial fibrillation and venous thromboembolism. The risk associated with bleeding events while taking dabigatran has been documented in multiple randomized controlled trials, but to date, no studies have focused on the risk of bleeding after dental extraction. Extraction of teeth is one of the most common surgical procedures and may cause significant bleeding, so a thorough understanding of the pharmacology of anticoagulant medications is required to prevent complications. With the increasing use of direct thrombin inhibitors, the safe management of patients taking these anticoagulants must be delineated. This review compares dabigatran and warfarin, especially in terms of their effects on dental and oral surgery practice, and examines best management of these patients in light of the existing literature. FAU - Davis, Clayton AU - Davis C AD - Department of Oral and Maxillofacial Surgery, Capital Health & Dalhousie University, QEII Health Science Centre, VG site, Halifax, Nova Scotia, Canada. cmd@dal.ca FAU - Robertson, Chad AU - Robertson C FAU - Shivakumar, Sudeep AU - Shivakumar S FAU - Lee, Min AU - Lee M LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - Canada TA - J Can Dent Assoc JT - Journal (Canadian Dental Association) JID - 7907605 RN - 0 (Antithrombins) RN - 0 (Benzimidazoles) RN - 0 (Pyridines) RN - 11P2JDE17B (beta-Alanine) RN - 5Q7ZVV76EI (Warfarin) RN - I0VM4M70GC (Dabigatran) SB - D SB - IM MH - Administration, Oral MH - Antithrombins/administration & dosage/adverse effects/*pharmacology/therapeutic use MH - Benzimidazoles/administration & dosage/adverse effects/*pharmacology/therapeutic use MH - Dabigatran MH - Drug Interactions MH - Humans MH - International Normalized Ratio MH - Postoperative Hemorrhage/etiology MH - Pyridines/administration & dosage/adverse effects/pharmacology/therapeutic use MH - *Surgery, Oral MH - *Tooth Extraction MH - Warfarin/pharmacology/therapeutic use MH - beta-Alanine/administration & dosage/adverse effects/*analogs & derivatives/pharmacology/therapeutic use EDAT- 2013/08/08 06:00 MHDA- 2014/02/22 06:00 CRDT- 2013/08/08 06:00 PHST- 2013/08/08 06:00 [entrez] PHST- 2013/08/08 06:00 [pubmed] PHST- 2014/02/22 06:00 [medline] PST - ppublish SO - J Can Dent Assoc. 2013;79:d74. PMID- 2417648 OWN - NLM STAT- MEDLINE DCOM- 19860324 LR - 20190828 IS - 0263-7103 (Print) IS - 0263-7103 (Linking) VI - 25 IP - 1 DP - 1986 Feb TI - Anti-inflammatory effects of ultrasound therapy: evidence for a major placebo effect. PG - 77-81 AB - The value of therapeutic ultrasound (US) for reducing inflammation was tested in a double-blind controlled study in 150 patients following surgical removal of impacted lower third molars. Facial swelling, trismus, pain and serum C-reactive protein (CRP) were significantly reduced in the US-treated groups and in a placebo group ('mock' US) compared with an untreated control group. The majority of the anti-inflammatory activity was attributable to the placebo effect, and the highest intensity of US (1.5 W.cm-2) was consistently less beneficial than the lower intensities (0.1 and 0.5 W.cm-2) and the mock US. FAU - Hashish, I AU - Hashish I FAU - Harvey, W AU - Harvey W FAU - Harris, M AU - Harris M LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - England TA - Br J Rheumatol JT - British journal of rheumatology JID - 8302415 RN - 0 (Placebos) RN - 7S5I7G3JQL (Dexamethasone) SB - AIM SB - IM MH - Adolescent MH - Adult MH - Dexamethasone/therapeutic use MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third MH - Palliative Care MH - Placebos/*therapeutic use MH - Postoperative Complications MH - Sex Factors MH - Stomatitis/drug therapy/etiology/*therapy MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery MH - Trismus/drug therapy/therapy MH - Ultrasonic Therapy/*standards EDAT- 1986/02/01 00:00 MHDA- 1986/02/01 00:01 CRDT- 1986/02/01 00:00 PHST- 1986/02/01 00:00 [pubmed] PHST- 1986/02/01 00:01 [medline] PHST- 1986/02/01 00:00 [entrez] AID - 10.1093/rheumatology/25.1.77 [doi] PST - ppublish SO - Br J Rheumatol. 1986 Feb;25(1):77-81. doi: 10.1093/rheumatology/25.1.77. PMID- 24560173 OWN - NLM STAT- MEDLINE DCOM- 20140605 LR - 20140418 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 72 IP - 5 DP - 2014 May TI - Use of lincomycin-impregnated demineralized freeze-dried bone allograft in the periodontal defect after third molar surgery. PG - 850-7 LID - S0278-2391(13)01442-0 [pii] LID - 10.1016/j.joms.2013.11.028 [doi] AB - PURPOSE: The aim of the present study was to evaluate the periodontal regenerative capacity of demineralized freeze-dried bone allograft (DFDBA) alone or used with local lincomycin. MATERIALS AND METHODS: In the present single-blind, randomized, controlled clinical trial, 20 subjects 26 years old or older, requiring extraction of bilateral third molars (M3s), were included. Each subject was randomly assigned to receive either DFDBA or DFDBA plus lincomycin therapy. Within the subjects, 1 M3 site was randomly selected to be the experimental site and the contralateral served as the control and was permitted to heal without intervention. The primary variables were changes in the probing depth (PD), clinical alveolar bone levels (ABLs), and radiographic alveolar bone density (ABD) on the distal aspect of second molar between baseline (immediately postoperatively) and 26 weeks postoperatively (T26). Appropriate sample sizes and descriptive, bivariate, and multivariate statistics were computed. RESULTS: For both treatment and control sites, between T0 and T26, statistically significant improvements were seen in the ABLs and ABD (P < .05). Within-subject comparisons showed no significant differences in PD, ABL, or ABD between the treatment and control M3 sites at T0 or T26 (P > .05). Also, no significant differences were found in the PD, ABL, or ABD between the 2 treatment M3 sites at T26 (P > .05). CONCLUSIONS: The results of the present study have revealed that the PD, ABL, and ABD improved after M3 removal in subjects 26 years old or older, irrespective of the treatment or control group. Reconstructive procedures (e.g., DFDBA with or without lincomycin therapy) did not offer predictable benefits compared with a no-treatment protocol in patients younger than 30 years old. CI - Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Tabrizi, Reza AU - Tabrizi R AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Shiraz University of Medical Science School of Dentistry, Shiraz, Iran. FAU - Khorshidi, Hooman AU - Khorshidi H AD - Assistant Professor, Department of Periodontology, Shiraz University of Medical Science School of Dentistry, Shiraz, Iran. FAU - Shahidi, Shoaleh AU - Shahidi S AD - Associate Professor, Biomaterial Research Center, Department of Oral and Maxillofacial Radiology, Shiraz University of Medical Science School of Dentistry, Shiraz, Iran. FAU - Gholami, Mehdi AU - Gholami M AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, North Khorasan University of Medical Science School of Dentistry, Bojnurd, Iran. Electronic address: gholami42143@yahoo.com. FAU - Kalbasi, Saman AU - Kalbasi S AD - Senior Resident, Department of Oral and Maxillofacial Surgery, Hamadan University of Medical Science School of Dentistry, Hamadan, Iran. FAU - Khayati, Adell AU - Khayati A AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Kordestan University of Medical Science, School of Dentistry, Sanandaj, Iran. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20131211 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Bacterial Agents) RN - BOD072YW0F (Lincomycin) SB - AIM SB - D SB - IM MH - Adult MH - Allografts/*transplantation MH - Alveolar Process/pathology MH - Anti-Bacterial Agents/*administration & dosage MH - Bone Demineralization Technique MH - Bone Density/physiology MH - Bone Transplantation/*methods MH - Cohort Studies MH - Female MH - Follow-Up Studies MH - Freeze Drying MH - Humans MH - Lincomycin/*administration & dosage MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Periodontal Pocket/classification MH - Reconstructive Surgical Procedures/*methods MH - Single-Blind Method MH - Tooth Extraction/*methods MH - Tooth Socket/*surgery MH - Tooth, Impacted/surgery MH - Wound Healing/physiology EDAT- 2014/02/25 06:00 MHDA- 2014/06/06 06:00 CRDT- 2014/02/25 06:00 PHST- 2013/05/31 00:00 [received] PHST- 2013/11/08 00:00 [revised] PHST- 2013/11/27 00:00 [accepted] PHST- 2014/02/25 06:00 [entrez] PHST- 2014/02/25 06:00 [pubmed] PHST- 2014/06/06 06:00 [medline] AID - S0278-2391(13)01442-0 [pii] AID - 10.1016/j.joms.2013.11.028 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2014 May;72(5):850-7. doi: 10.1016/j.joms.2013.11.028. Epub 2013 Dec 11. PMID- 15476903 OWN - NLM STAT- MEDLINE DCOM- 20041029 LR - 20190922 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 26 IP - 8 DP - 2004 Aug TI - Dose-ranging analgesic study of Prosorb diclofenac potassium in postsurgical dental pain. PG - 1215-27 AB - BACKGROUND: ProSorb diclofenac potassium (K) is a novel, liquid-filled rapid-dispersion formulation of the nonsteroidal anti-inflammatory drug diclofenac, placed into soft gelatin capsules. Its time to maximal plasma drug concentration has been shown to be approximately half, and its maximal plasma drug concentration nearly twice, that of immediate-release diclofenac K tablets. OBJECTIVE: This study compared the analgesic dose-response relationship and tolerability of 3 doses of ProSorb diclofenac K and placebo in the treatment of pain after dental impaction surgery. METHODS: This randomized, double-blind, double-dummy, placebo-controlled parallel-group study was conducted at 6 centers across the United States. Patients aged 18 to 65 years with moderate or severe pain after the removal of > or =1 impacted mandibular third molar were randomly assigned to receive a single dose of ProSorb diclofenac K 25, 50, or 100 mg or placebo. Pain intensity and relief were assessed up to 6 hours after dosing. Rescue treatment was allowed after 1 hour. Efficacy end points included the summed pain intensity difference over 3 and 6 hours (SPID3 and 6); total pain relief at 3 and 6 hours (TOTPAR3 and 6); median times to onset of perceptible and meaningful relief (analgesic onset) and rescue medication use (analgesic duration); and cumulative percentage of patients using rescue medication. Tolerability was assessed using vital sign measurements and spontaneous reporting of adverse events. RESULTS: A total of 265 patients (154 women, 111 men; mean age, 23.3 years) were enrolled. All 3 ProSorb diclofenac K groups showed higher SPID6 and TOTPAR6 scores and longer median times to rescue medication use than the placebo group (all, P < 0.001). For these end points, a dose-response relationship was evident between the 100-mg dose and the 25- and 50-mg doses (P < or = 0.05); the 25- and 50-mg doses were similar. In the diclofenac groups, median onset times for first perceptible (< or =22.5 min) and meaningful (< or =53.0 min) relief were significantly more rapid than placebo (P < or = 0.01). Proportions of patients requiring rescue analgesic were < or =50.8% with diclofenac compared with 79.4% with placebo. Proportions of patients assigning a global evaluation of good or better was > or =68% with diclofenac compared with 21% for placebo. Tolerability was similar across all treatment groups. CONCLUSION: In this study of patients treated for pain following dental impaction surgery, single doses of ProSorb diclofenac K 25, 50, and 100 mg were more efficacious than placebo with respect to reduction of pain. All 3 doses provided a rapid analgesic onset and were well tolerated. FAU - Hersh, Elliot V AU - Hersh EV AD - Department of Oral Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104-6030, USA. evhersh@pobox.upenn.edu FAU - Levin, Lawrence M AU - Levin LM FAU - Adamson, Dennis AU - Adamson D FAU - Christensen, Steven AU - Christensen S FAU - Kiersch, Theodore A AU - Kiersch TA FAU - Noveck, Robert AU - Noveck R FAU - Watson, Gene 2nd AU - Watson G 2nd FAU - Lyon, James A AU - Lyon JA LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Analgesics) RN - 0 (Cyclooxygenase Inhibitors) RN - 144O8QL0L1 (Diclofenac) SB - IM MH - Adolescent MH - Adult MH - Analgesics/administration & dosage/*therapeutic use MH - Cyclooxygenase Inhibitors/administration & dosage/*therapeutic use MH - Diclofenac/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/pathology/*prevention & control MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - United States EDAT- 2004/10/13 09:00 MHDA- 2004/10/30 09:00 CRDT- 2004/10/13 09:00 PHST- 2004/05/27 00:00 [accepted] PHST- 2004/10/13 09:00 [pubmed] PHST- 2004/10/30 09:00 [medline] PHST- 2004/10/13 09:00 [entrez] AID - S0149-2918(04)80033-X [pii] AID - 10.1016/s0149-2918(04)80033-x [doi] PST - ppublish SO - Clin Ther. 2004 Aug;26(8):1215-27. doi: 10.1016/s0149-2918(04)80033-x. PMID- 361026 OWN - NLM STAT- MEDLINE DCOM- 19781220 LR - 20190827 IS - 0045-0421 (Print) IS - 0045-0421 (Linking) VI - 23 IP - 2 DP - 1978 Apr TI - A clinical evaluation of benzydamine hydrochloride. PG - 164-6 AB - A double-blind clinical trial of the effects of the use of benzydamine hydrochloride for patients undergoing the surgical removal of impacted lower third molar teeth showed no significant effects on swelling and trismus between control and experimental groups, although a significant reduction in the post-operative consumption of analgesics was noted. FAU - Hunter, K M AU - Hunter KM LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Australia TA - Aust Dent J JT - Australian dental journal JID - 0370612 RN - 0 (Analgesics) RN - 0 (Pyrazoles) RN - 4O21U048EF (Benzydamine) SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesics/administration & dosage MH - Benzydamine/*therapeutic use MH - Clinical Trials as Topic MH - Double-Blind Method MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Pain, Postoperative/prevention & control MH - Postoperative Complications/*prevention & control MH - Pyrazoles/*therapeutic use MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control EDAT- 1978/04/01 00:00 MHDA- 1978/04/01 00:01 CRDT- 1978/04/01 00:00 PHST- 1978/04/01 00:00 [pubmed] PHST- 1978/04/01 00:01 [medline] PHST- 1978/04/01 00:00 [entrez] AID - 10.1111/j.1834-7819.1978.tb02905.x [doi] PST - ppublish SO - Aust Dent J. 1978 Apr;23(2):164-6. doi: 10.1111/j.1834-7819.1978.tb02905.x. PMID- 24589242 OWN - NLM STAT- MEDLINE DCOM- 20140711 LR - 20140516 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 72 IP - 6 DP - 2014 Jun TI - Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial. PG - 1043-8 LID - S0278-2391(14)00093-7 [pii] LID - 10.1016/j.joms.2013.12.035 [doi] AB - PURPOSE: The purpose of the present study was to compare the effect of oral bromelain (4 × 250 mg) versus oral diclofenac sodium (4 × 25 mg) on pain, swelling, trismus, and quality of life (QOL) after surgical removal of impacted lower third molars. PATIENTS AND METHODS: A randomized, double-blind, placebo-controlled study was planned. The sample included patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar. The patients were randomly distributed into 1 of 3 groups: bromelain, diclofenac, and placebo. Treatment started 1 day before surgery and continued for 4 days. The predictor variable was the type of the drug given to the patients. The outcome variables were pain, swelling, and trismus, which were measured at 1, 3, and 7 days postoperatively. The other study variables included QOL measures to assess the patients' perception regarding the effect of surgery on their well-being and daily activities. A validated questionnaire was used to measure QOL. The data were analyzed using analysis of variance, multiple measures analysis of variance, or Pearson's χ(2) test, as appropriate. P < .05 was considered significant. RESULTS: A total of 45 subjects requiring surgical removal of a single impacted mandibular third molar under local anesthesia were included in the present study. The bromelain and diclofenac groups both showed a significant reduction in pain compared with the placebo group at all intervals (P < .05). Diclofenac also resulted in a significant reduction of swelling at 3 and 7 days, and bromelain resulted in an insignificant reduction. A nonsignificant reduction in trismus occurred in both treatment groups compared with the placebo group. Both treatment groups also showed a significant difference in the effect on QOL in most subscales and total scores (P < .05). The effect was comparable between the 2 treatment groups for all parameters and at all intervals. CONCLUSIONS: The results of our study have shown that oral bromelain is an effective therapy to improve the QOL after surgical removal of impacted lower third molars, with an effect on the postoperative sequelae comparable to that of preemptive diclofenac sodium. CI - Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Majid, Omer Waleed AU - Majid OW AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Mosul College of Dentistry, Mosul, Iraq. Electronic address: omerw_majid@yahoo.co.uk. FAU - Al-Mashhadani, Bashar Adil AU - Al-Mashhadani BA AD - Postgraduate Student, Master's Degree, Department of Oral and Maxillofacial Surgery, University of Mosul College of Dentistry, Mosul, Iraq. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20140116 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 144O8QL0L1 (Diclofenac) RN - 9001-00-7 (Bromelains) SB - AIM SB - D SB - IM MH - Activities of Daily Living MH - Administration, Oral MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/administration & dosage/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Attitude to Health MH - Bromelains/administration & dosage/*therapeutic use MH - Diclofenac/administration & dosage/therapeutic use MH - Double-Blind Method MH - Edema/*prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Postoperative Complications/prevention & control MH - *Premedication MH - Prospective Studies MH - *Quality of Life MH - *Tooth Extraction/adverse effects/psychology MH - Tooth, Impacted/prevention & control/surgery MH - Treatment Outcome MH - Trismus/prevention & control MH - Young Adult EDAT- 2014/03/05 06:00 MHDA- 2014/07/12 06:00 CRDT- 2014/03/05 06:00 PHST- 2013/10/24 00:00 [received] PHST- 2013/12/29 00:00 [revised] PHST- 2013/12/30 00:00 [accepted] PHST- 2014/03/05 06:00 [entrez] PHST- 2014/03/05 06:00 [pubmed] PHST- 2014/07/12 06:00 [medline] AID - S0278-2391(14)00093-7 [pii] AID - 10.1016/j.joms.2013.12.035 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2014 Jun;72(6):1043-8. doi: 10.1016/j.joms.2013.12.035. Epub 2014 Jan 16. PMID- 23649050 OWN - NLM STAT- MEDLINE DCOM- 20140424 LR - 20151119 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 23 IP - 6 DP - 2012 Nov-Dec TI - Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery. PG - 709-13 LID - 10.4103/0970-9290.111243 [doi] AB - INTRODUCTION: Surgical extraction of lower 3 rd molar is the most frequent intervention in oral surgery. This procedure is often associated with significant post operative swelling that may have both biological and social implications. Various studies have been done using different anti inflammatory drugs to study their impact on inflammation. MATERIAL AND METHODS: This study was conducted on 110 patients who had undergone surgical removal of mandibular third molar. The subjects were divided into two groups by double blind method. In addition to post operative swelling and pain , trismus was evaluated using two different groups of drugs. RESULTS: One group was administered 1 mg of dexamethazone every 8 hours for 3 days post operatively. The other group was administered 10 mg of serratiopaptidase every 8 hours for 3 days post operatively. Swelling, pain and trismus were assessed on the 1 st , 3 rd , 5 th and 7 th post operative days. The results of the studies were statistically analysed. CONCLUSION: The results showed dexamethazone was more effective in reduction of swelling and pain in comparison with serratiopaptidase. Both dexamethazone and serratiopaptidase had the same effect on trismus. FAU - Murugesan, K AU - Murugesan K AD - Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College and Hospital, Alapakkam Main Road, Maduravoyal, Chennai, Tamil Nadu, India. FAU - Sreekumar, K AU - Sreekumar K FAU - Sabapathy, B AU - Sabapathy B LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 7S5I7G3JQL (Dexamethasone) RN - EC 3.4.- (Peptide Hydrolases) RN - NL053ABE4J (serratiopeptidase) SB - D MH - Anti-Inflammatory Agents/administration & dosage/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Cheek/pathology MH - Dexamethasone/administration & dosage/*therapeutic use MH - Double-Blind Method MH - Edema/classification/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Inflammation MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/classification/prevention & control MH - Peptide Hydrolases/administration & dosage/*therapeutic use MH - Postoperative Complications/*prevention & control MH - Range of Motion, Articular/drug effects MH - Serratia MH - Tooth Socket/surgery MH - Tooth, Impacted/*surgery MH - Trismus/*prevention & control EDAT- 2013/05/08 06:00 MHDA- 2014/04/25 06:00 CRDT- 2013/05/08 06:00 PHST- 2013/05/08 06:00 [entrez] PHST- 2013/05/08 06:00 [pubmed] PHST- 2014/04/25 06:00 [medline] AID - IndianJDentRes_2012_23_6_709_111243 [pii] AID - 10.4103/0970-9290.111243 [doi] PST - ppublish SO - Indian J Dent Res. 2012 Nov-Dec;23(6):709-13. doi: 10.4103/0970-9290.111243. PMID- 23200183 OWN - NLM STAT- MEDLINE DCOM- 20130517 LR - 20131121 IS - 1879-114X (Electronic) IS - 0149-2918 (Linking) VI - 34 IP - 12 DP - 2012 Dec TI - A randomized, double-blind, placebo-controlled study of acetaminophen 1000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. PG - 2247-2258.e3 LID - S0149-2918(12)00618-2 [pii] LID - 10.1016/j.clinthera.2012.11.003 [doi] AB - BACKGROUND: Although acetaminophen is one of the oldest and most widely used of all analgesic drugs, the incremental benefit of the 1000-mg dose compared with the 650-mg dose has been questioned. OBJECTIVE: The aim of this study was to assess the relative efficacy of acetaminophen 1000 mg versus acetaminophen 650 mg over a 6-hour period in patients experiencing at least moderate postsurgical dental pain. METHODS: This single-center, randomized, double-blind, placebo-controlled, single-dose study enrolled patients aged 16 to 50 years who experienced at least moderate pain after surgical removal of impacted third molars. Each patient received either acetaminophen 1000 mg (n = 239), acetaminophen 650 mg (n = 241), or placebo (n = 60) when they had at least moderate pain and a score ≥50 on the 100-mm Visual Analog Scale (VAS) postsurgically. Pain intensity and pain relief were measured over 6 hours (VAS 0-100 mm). RESULTS: All 540 patients (52% female; age range, 16-30 years; 95% white) were included in the efficacy analysis. For the primary efficacy endpoint (weighted sum of the pain intensity difference from baseline [PID] and pain relief [PAR] scores over 6 hours [SPRID6]), acetaminophen 1000 mg demonstrated a 24% improvement compared with acetaminophen 650 mg (529.4 vs 427.3; P = 0.001). In addition, acetaminophen 650 mg was significantly superior compared with placebo (P < 0.001). The weighted sum of PID over 6 hours (SPID6), the weighted total pain relief over 6 hours (TOTPAR6), and the percentage of patients with >50% of the maximum possible TOTPAR6 score were significantly greater for patients treated with acetaminophen 1000 mg compared with those receiving acetaminophen 650 mg (P ≤ 0.006) or placebo (P < 0.001) and for patients treated with acetaminophen 650 mg compared with placebo (P < 0.001). Time to rescue, rescue rates through 4 and 6 hours, and patient global assessment demonstrated similar findings. Patients treated with acetaminophen 1000 mg or 650 mg had a significantly different distribution in times to confirmed perceptible and meaningful pain relief compared with those receiving placebo (P < 0.001). Adverse events were reported by 18.5% of patients, with no clinically important difference between active treatment groups and placebo. CONCLUSIONS: Acetaminophen 1000 mg provided clinically meaningful and statistically significantly greater efficacy in treating postsurgical dental pain compared with acetaminophen 650 mg and placebo. The outcomes of this study are limited to the single-dose design of this study. ClinicalTrials.gov identifier: NCT01115673. CI - Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved. FAU - Qi, Daniel S AU - Qi DS AD - McNeil Consumer Healthcare, Fort Washington, Pennsylvania, USA. FAU - May, Lisa G AU - May LG FAU - Zimmerman, Brenda AU - Zimmerman B FAU - Peng, Penny AU - Peng P FAU - Atillasoy, Evren AU - Atillasoy E FAU - Brown, Jean D AU - Brown JD FAU - Cooper, Stephen A AU - Cooper SA LA - eng SI - ClinicalTrials.gov/NCT01115673 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20121128 PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/*therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Young Adult EDAT- 2012/12/04 06:00 MHDA- 2013/05/18 06:00 CRDT- 2012/12/04 06:00 PHST- 2012/06/29 00:00 [received] PHST- 2012/11/01 00:00 [revised] PHST- 2012/11/02 00:00 [accepted] PHST- 2012/12/04 06:00 [entrez] PHST- 2012/12/04 06:00 [pubmed] PHST- 2013/05/18 06:00 [medline] AID - S0149-2918(12)00618-2 [pii] AID - 10.1016/j.clinthera.2012.11.003 [doi] PST - ppublish SO - Clin Ther. 2012 Dec;34(12):2247-2258.e3. doi: 10.1016/j.clinthera.2012.11.003. Epub 2012 Nov 28. PMID- 21373203 OWN - NLM STAT- MEDLINE DCOM- 20110901 LR - 20181201 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 6 IP - 2 DP - 2011 Feb 23 TI - Beyond patient reported pain: perfusion magnetic resonance imaging demonstrates reproducible cerebral representation of ongoing post-surgical pain. PG - e17096 LID - 10.1371/journal.pone.0017096 [doi] LID - e17096 AB - Development of treatments for acute and chronic pain conditions remains a challenge, with an unmet need for improved sensitivity and reproducibility in measuring pain in patients. Here we used pulsed-continuous arterial spin-labelling [pCASL], a relatively novel perfusion magnetic-resonance imaging technique, in conjunction with a commonly-used post-surgical model, to measure changes in regional cerebral blood flow [rCBF] associated with the experience of being in ongoing pain. We demonstrate repeatable, reproducible assessment of ongoing pain that is independent of patient self-report. In a cross-over trial design, 16 participants requiring bilateral removal of lower-jaw third molars underwent pain-free pre-surgical pCASL scans. Following extraction of either left or right tooth, repeat scans were acquired during post-operative ongoing pain. When pain-free following surgical recovery, the pre/post-surgical scanning procedure was repeated for the remaining tooth. Voxelwise statistical comparison of pre and post-surgical scans was performed to reveal rCBF changes representing ongoing pain. In addition, rCBF values in predefined pain and control brain regions were obtained. rCBF increases (5-10%) representing post-surgical ongoing pain were identified bilaterally in a network including primary and secondary somatosensory, insula and cingulate cortices, thalamus, amygdala, hippocampus, midbrain and brainstem (including trigeminal ganglion and principal-sensory nucleus), but not in a control region in visual cortex. rCBF changes were reproducible, with no rCBF differences identified across scans within-session or between post-surgical pain sessions. This is the first report of the cerebral representation of ongoing post-surgical pain without the need for exogenous tracers. Regions of rCBF increases are plausibly associated with pain and the technique is reproducible, providing an attractive proposition for testing interventions for on-going pain that do not rely solely on patient self-report. Our findings have the potential to improve our understanding of the cerebral representation of persistent painful conditions, leading to improved identification of specific patient sub-types and implementation of mechanism-based treatments. FAU - Howard, Matthew A AU - Howard MA AD - Department of Neuroimaging, Institute of Psychiatry, Kings College London, London, United Kingdom. Matthew.Howard@kcl.ac.uk FAU - Krause, Kristina AU - Krause K FAU - Khawaja, Nadine AU - Khawaja N FAU - Massat, Nathalie AU - Massat N FAU - Zelaya, Fernando AU - Zelaya F FAU - Schumann, Gunter AU - Schumann G FAU - Huggins, John P AU - Huggins JP FAU - Vennart, William AU - Vennart W FAU - Williams, Steven C R AU - Williams SC FAU - Renton, Tara F AU - Renton TF LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20110223 TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Brain Mapping/methods MH - Cerebrovascular Circulation/physiology MH - Cross-Over Studies MH - Humans MH - *Magnetic Resonance Angiography/methods MH - Male MH - Molar, Third/surgery MH - Oral Surgical Procedures/adverse effects/rehabilitation MH - Orthognathic Surgical Procedures MH - Pain Measurement/*methods/*trends MH - Pain, Postoperative/*diagnosis/physiopathology MH - Postoperative Care/methods/trends MH - Postoperative Period MH - Self Concept MH - *Self Report MH - Young Adult PMC - PMC3044150 COIS- Competing Interests: Dr. Howard, Professors Schumann, Renton and Williams are all named principal investigators on a grant to do this work funded by Pfizer Global Research and Development. The salaries of Dr. Howard and Ms. Krause are funded by Pfizer. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. EDAT- 2011/03/05 06:00 MHDA- 2011/09/02 06:00 CRDT- 2011/03/05 06:00 PHST- 2010/08/26 00:00 [received] PHST- 2011/01/20 00:00 [accepted] PHST- 2011/03/05 06:00 [entrez] PHST- 2011/03/05 06:00 [pubmed] PHST- 2011/09/02 06:00 [medline] AID - PONE-D-10-01283 [pii] AID - 10.1371/journal.pone.0017096 [doi] PST - epublish SO - PLoS One. 2011 Feb 23;6(2):e17096. doi: 10.1371/journal.pone.0017096. PMID- 2395047 OWN - NLM STAT- MEDLINE DCOM- 19901005 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 48 IP - 9 DP - 1990 Sep TI - Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. PG - 945-52 AB - Pain, swelling, loss of function, and hyperthermia are acute postoperative sequelae of inflammation due to tissue injury during surgical procedures. Pharmacologic strategies for minimizing the clinical manifestations of surgical trauma are often directed toward blocking the formation or inhibiting the effects of the biochemical mediators of acute inflammation. This study compared two nonsteroidal anti-inflammatory drugs (NSAIDs), flurbiprofen and ibuprofen, with a prototype glucocorticoid, methylprednisolone, in two replicate placebo-controlled studies for suppression of inflammation due to the surgical removal of impacted third molars. The results indicate that NSAIDs produce greater initial analgesia than do steroids, whereas steroids result in greater suppression of swelling and less loss of function. Examination of the pooled data from the two studies indicates that NSAID pretreatment results in a modest suppression of swelling in comparison with placebo. These data suggest that the acute analgesic effects of NSAIDs in the oral surgery model are due to suppression of a nociceptive process, presumably prostaglandin formation, rather than a generalized anti-inflammatory effect. FAU - Troullos, E S AU - Troullos ES AD - Clinical Pharmacology Unit, National Institute of Dental Research, National Institute of Health, Bethesda, MD 20892. FAU - Hargreaves, K M AU - Hargreaves KM FAU - Butler, D P AU - Butler DP FAU - Dionne, R A AU - Dionne RA LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 5GRO578KLP (Flurbiprofen) RN - WK2XYI10QM (Ibuprofen) RN - X4W7ZR7023 (Methylprednisolone) SB - AIM SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Evaluation Studies as Topic MH - Female MH - Fever/drug therapy/prevention & control MH - Flurbiprofen/*administration & dosage/therapeutic use MH - Humans MH - Ibuprofen/*administration & dosage/therapeutic use MH - Inflammation/*drug therapy/prevention & control MH - Male MH - Methylprednisolone/*administration & dosage/therapeutic use MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy/prevention & control MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Trismus/*drug therapy/prevention & control MH - Vertical Dimension EDAT- 1990/09/01 00:00 MHDA- 1990/09/01 00:01 CRDT- 1990/09/01 00:00 PHST- 1990/09/01 00:00 [pubmed] PHST- 1990/09/01 00:01 [medline] PHST- 1990/09/01 00:00 [entrez] AID - 0278-2391(90)90007-O [pii] AID - 10.1016/0278-2391(90)90007-o [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1990 Sep;48(9):945-52. doi: 10.1016/0278-2391(90)90007-o. PMID- 26202994 OWN - NLM STAT- MEDLINE DCOM- 20151110 LR - 20150821 IS - 1544-0591 (Electronic) IS - 0022-0345 (Linking) VI - 94 IP - 9 Suppl DP - 2015 Sep TI - Efficacy and Safety of 2% and 4% Articaine for Lower Third Molar Surgery. PG - 166S-73S LID - 10.1177/0022034515596313 [doi] AB - This double-blind crossover randomized clinical trial compared the efficacy of 2 concentrations of articaine, 2% (A2) and 4% (A4), with 1:200,000 epinephrine, for lower third molar removal. During 2 separate appointments with either A2 or A4, both similarly positioned lower third molars in 46 volunteers were extracted. The following were evaluated: onset and duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative analgesia, and mouth opening and wound healing during the 7th postoperative day, along with the incidence, type, and severity of adverse reactions. Nearly identical volumes of both anesthetic solutions were used for each appointment: 3.4 ± 0.9 mL ≈ 68 mg of articaine (A2) and 3.3 ± 0.8 mL ≈ 132 mg of articaine (A4). Statistical analysis indicated no differences in onset or duration of anesthetic action on soft tissues or duration of postoperative analgesia evoked by A2 and A4 anesthetic solutions (P > 0.05). The surgeon's rating of intraoperative bleeding was considered minimal throughout all surgery with both anesthetic solutions. While transient changes in blood pressure, heart rate, and oxygen saturation were observed, these factors were clinically insignificant and were uninfluenced by articaine concentration (P > 0.05). No systemic or local adverse reactions were observed in the preoperative and postoperative periods due to A2 or A4, but 1 case of bilateral paresthesia was observed. There were no significant differences between preoperative and postoperative (7th day) values of mouth opening and wound healing whether volunteers received A2 or A4 (P > 0.05). In conclusion, both A2 and A4, administered in equal volumes, were effective and safe during lower third molar surgery, and no significant differences were found between their efficacy and safety (ClinicalTrials.gov NCT02457325). CI - © International & American Associations for Dental Research. FAU - Senes, A M AU - Senes AM AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Calvo, A M AU - Calvo AM AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Colombini-Ishikiriama, B L AU - Colombini-Ishikiriama BL AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Gonçalves, P Z AU - Gonçalves PZ AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Dionísio, T J AU - Dionísio TJ AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Sant'ana, E AU - Sant'ana E AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Brozoski, D T AU - Brozoski DT AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Lauris, J R P AU - Lauris JR AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Faria, F A C AU - Faria FA AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. FAU - Santos, C F AU - Santos CF AD - Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil cfsantos@fob.usp.br. LA - eng SI - ClinicalTrials.gov/NCT02457325 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150722 PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 RN - 0 (Anesthetics, Local) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - D3SQ406G9X (Carticaine) RN - S88TT14065 (Oxygen) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/methods MH - Anesthetics, Local/*administration & dosage/adverse effects MH - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use MH - Blood Loss, Surgical MH - Blood Pressure/physiology MH - Carticaine/*administration & dosage/adverse effects MH - Cross-Over Studies MH - Double-Blind Method MH - Female MH - Follow-Up Studies MH - Heart Rate/physiology MH - Humans MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Nerve Block/methods MH - Oxygen/blood MH - Pain, Postoperative/prevention & control MH - Piroxicam/therapeutic use MH - Safety MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Wound Healing/physiology MH - Young Adult OTO - NOTNLM OT - epinephrine OT - hemodynamics OT - inferior alveolar nerve block OT - local anesthesia OT - pain OT - trismus EDAT- 2015/07/24 06:00 MHDA- 2015/11/11 06:00 CRDT- 2015/07/24 06:00 PHST- 2015/07/24 06:00 [entrez] PHST- 2015/07/24 06:00 [pubmed] PHST- 2015/11/11 06:00 [medline] AID - 0022034515596313 [pii] AID - 10.1177/0022034515596313 [doi] PST - ppublish SO - J Dent Res. 2015 Sep;94(9 Suppl):166S-73S. doi: 10.1177/0022034515596313. Epub 2015 Jul 22. PMID- 16802646 OWN - NLM STAT- MEDLINE DCOM- 20060811 LR - 20131121 IS - 0361-7734 (Print) IS - 0361-7734 (Linking) VI - 31 IP - 3 DP - 2006 May-Jun TI - The effectiveness of alumina powder on carious dentin removal. PG - 371-6 AB - This study determined the size of aluminum oxide particles used in an air abrasion system that is able to remove carious dentin tissue with maximum preservation of sound structure. Thirty extracted and carious-free third molars were used in this study. The dentin sample was obtained by sectioning the middle of the crown longitudinal to the long axis of the tooth in a mesio-distal direction. One half of the crown corresponded to the sound dentin group (SD), while the other half was used to develop artificial caries, constituting the carious dentin group (CD). The specimens were air abraded for 15 seconds. The SD and CD groups were each randomly divided into three subgroups (N=10) according to the particle diameter employed (27, 50 and 125 microm). The prepared cavity was perpendicularly cut in half, and the profiles of all hemi-fragments were observed using SEM microscopy. The cavity measurements were made using a modified cephalometric analysis. The 27, 50 and 125 microm aluminum oxide particles did not present selectivity in the removal of carious dentin. However, when using the air abrasive technique for carious dentin treatment, the use of 27 and 50 microm aluminum oxide particles is recommended, due to their capacity to remove less sound tissue than the 125 microm particles. FAU - Motisuki, Cristiane AU - Motisuki C AD - Department of Pediatric Dentistry, Araraquara Dental School, State University of São Paulo, Araraquara, São Paulo, Brazil. cmotisuki@yahoo.com.br FAU - Lima, L M AU - Lima LM FAU - Bronzi, E S AU - Bronzi ES FAU - Spolidorio, D M P AU - Spolidorio DM FAU - Santos-Pinto, L AU - Santos-Pinto L LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oper Dent JT - Operative dentistry JID - 7605679 RN - 0 (Dental Materials) RN - LMI26O6933 (Aluminum Oxide) SB - D MH - Air Abrasion, Dental/*methods MH - Aluminum Oxide/chemistry/*therapeutic use MH - Dental Caries/microbiology/pathology/*therapy MH - Dental Cavity Preparation/methods MH - Dental Materials/chemistry/*therapeutic use MH - Dentin/*ultrastructure MH - Humans MH - Lactobacillus acidophilus/physiology MH - Materials Testing MH - Microscopy, Electron, Scanning MH - Molar, Third MH - Odontometry MH - Particle Size MH - Streptococcus mutans/physiology EDAT- 2006/06/29 09:00 MHDA- 2006/08/12 09:00 CRDT- 2006/06/29 09:00 PHST- 2006/06/29 09:00 [pubmed] PHST- 2006/08/12 09:00 [medline] PHST- 2006/06/29 09:00 [entrez] AID - 10.2341/05-48 [doi] PST - ppublish SO - Oper Dent. 2006 May-Jun;31(3):371-6. doi: 10.2341/05-48. PMID- 24385748 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140103 LR - 20181113 IS - 1300-7777 (Print) IS - 1308-5263 (Electronic) IS - 1300-7777 (Linking) VI - 30 IP - 1 DP - 2013 Mar TI - The Effectiveness of a New Hemostatic Agent (Ankaferd Blood Stopper) for the Control of Bleeding following Tooth Extraction in Hemophilia: A Controlled Clinical Trial. PG - 19-24 LID - 10.4274/tjh.2012.0036 [doi] AB - OBJECTIVE: To assess the hemostatic efficacy of a new local hemostatic agent, Ankaferd Blood Stopper (ABS), for the control of bleeding following tooth extraction in hemophiliacs. MATERIALS AND METHODS: Simple tooth extractions were performed in 27 hemophilia A patients. In the treatment group (n=17) local hemostasis was achieved via application of ABS to the extraction sockets, whereas in the control group (n=10) local hemostasis was achieved via direct packing with gauze. RESULTS: In all, 57 (21 primary and 36 permanent) teeth extractions were performed in 27 hemophilia A patients. There were no significant differences in age or factor VIII level distribution between the 2 groups (p>0.05). The most significant clinical difference between the groups was associated with the use of ABS; those in the treatment group had significantly shorter duration of bleeding (p=0.002). CONCLUSION: This is the first study to evaluate the efficacy of ABS for the control of bleeding following tooth extraction in hemophiliacs. ABS can be considered an alternative local hemostatic agent for reducing clotting factor concentrates in hemophilia patients. CONFLICT OF INTEREST: None declared. FAU - Kazancıoğlu, Hakkı Oğuz AU - Kazancıoğlu HO AD - Bezmialem Vakıf University, School of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey. FAU - Cakır, Onur AU - Cakır O AD - İstanbul University, School of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey. FAU - Ak, Gülsüm AU - Ak G AD - İstanbul University, School of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey. FAU - Zülfikar, Bülent AU - Zülfikar B AD - İstanbul University, Cerrahpaşa School of Medicine, Department of Pediatric Hematology and Oncology, İstanbul, Turkey. LA - eng PT - Journal Article DEP - 20130305 TA - Turk J Haematol JT - Turkish journal of haematology : official journal of Turkish Society of Haematology JID - 9606065 PMC - PMC3781667 OTO - NOTNLM OT - Ankaferd Blood Stopper OT - Hemophilia OT - Hemostasis OT - Oral surgery EDAT- 2014/01/05 06:00 MHDA- 2014/01/05 06:01 CRDT- 2014/01/04 06:00 PHST- 2012/03/13 00:00 [received] PHST- 2012/05/10 00:00 [accepted] PHST- 2014/01/04 06:00 [entrez] PHST- 2014/01/05 06:00 [pubmed] PHST- 2014/01/05 06:01 [medline] AID - 292 [pii] AID - 10.4274/tjh.2012.0036 [doi] PST - ppublish SO - Turk J Haematol. 2013 Mar;30(1):19-24. doi: 10.4274/tjh.2012.0036. Epub 2013 Mar 5. PMID- 20005673 OWN - NLM STAT- MEDLINE DCOM- 20100518 LR - 20181201 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 39 IP - 1 DP - 2010 Jan TI - Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. PG - 36-41 LID - 10.1016/j.ijom.2009.11.009 [doi] AB - The main purpose of this study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration (Cmax) was 82+/-15 microg/l. On isolated human infraorbital artery, ropivacaine (10(-4)M) induced endothelium-independent contraction. This study suggests that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not successful postoperative pain control for the surgical removal of upper third molars. CI - Copyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Brkovic, B M B AU - Brkovic BM AD - Clinic of Oral Surgery, Faculty of Dentistry, University of Belgrade, Belgrade, Serbia. FAU - Zlatkovic, M AU - Zlatkovic M FAU - Jovanovic, D AU - Jovanovic D FAU - Stojic, D AU - Stojic D LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20091214 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 0 (Amides) RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anesthetics, Local) RN - 7IO5LYA57N (Ropivacaine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adult MH - Amides/*administration & dosage/blood MH - Analgesics, Non-Narcotic/therapeutic use MH - Anesthesia, Dental MH - Anesthetics, Local/*administration & dosage/blood MH - Arteries/drug effects MH - Blood Pressure/drug effects MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Endothelium, Vascular/drug effects MH - Female MH - Heart Rate/drug effects MH - Humans MH - Ibuprofen/therapeutic use MH - Injections MH - Male MH - Maxilla/*surgery MH - Molar, Third/*surgery MH - Orbit/blood supply/drug effects MH - Pain Measurement MH - Pain, Postoperative/drug therapy MH - Regional Blood Flow/drug effects MH - Ropivacaine MH - Time Factors MH - Tooth Extraction/*methods MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Vasoconstriction/drug effects MH - Young Adult EDAT- 2009/12/17 06:00 MHDA- 2010/05/19 06:00 CRDT- 2009/12/17 06:00 PHST- 2008/10/21 00:00 [received] PHST- 2009/07/19 00:00 [revised] PHST- 2009/11/17 00:00 [accepted] PHST- 2009/12/17 06:00 [entrez] PHST- 2009/12/17 06:00 [pubmed] PHST- 2010/05/19 06:00 [medline] AID - S0901-5027(09)01174-6 [pii] AID - 10.1016/j.ijom.2009.11.009 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2010 Jan;39(1):36-41. doi: 10.1016/j.ijom.2009.11.009. Epub 2009 Dec 14. PMID- 15583533 OWN - NLM STAT- MEDLINE DCOM- 20050201 LR - 20190911 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 98 IP - 6 DP - 2004 Dec TI - A prospective randomized crossover study of the preemptive analgesic effect of nitrous oxide in oral surgery. PG - 637-42 AB - OBJECTIVE: Preliminary animal data has shown that nitrous oxide has a preemptive analgesic effect on postoperative pain. Whether a similar effect occurs in humans is not established. In this prospective randomized crossover study, we investigated the effect of preincisional versus postincisional nitrous oxide on postoperative oral surgical pain.Study design The trial was a crossover study where 36 patients had each of their symmetrical impacted mandibular third molars randomly scheduled for removal in 2 sessions. Each of the 36 patients acted as his or her own control; one side of the jaw was allocated randomly to receive nitrous oxide preoperatively (pretreated side) and the other side postoperatively (posttreated side). The pretreated side received 50% nitrous oxide preoperatively for 20 minutes and 100% oxygen postoperatively for 20 minutes as placebo. The posttreated side received 100% oxygen preoperatively for 20 minutes and 50% nitrous oxide postoperatively for 20 minutes. The difference in postoperative pain between the pretreated and posttreated sides was assessed by 4 primary end-points: pain intensity as measured by a 100-mm visual analog scale (VAS) hourly for 8 hours, time to first analgesic, total analgesic consumption during the first 48 hours, and a 5-point categorical patient global assessment scale (0=poor, 1=fair, 2=good, 3=very good, and 4=excellent). RESULTS: The VAS scores did not differ between the 2 sides at any time (P=.50): neither did the time to first analgesic (P=.8), amount of total analgesic consumption (P=.77), and patient's global assessment differ (P=.63). CONCLUSION: Our results do not support the preliminary animal data that nitrous oxide has a preemptive analgesic effect for postoperative pain. 50% nitrous oxide administered preoperatively for 20 minutes has no preemptive analgesic effect on postextraction pain. FAU - Ong, K S AU - Ong KS AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore. FAU - Seymour, R A AU - Seymour RA FAU - Tan, J M L AU - Tan JM LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Analgesics) RN - 0 (Anesthetics, Inhalation) RN - 0 (Anesthetics, Local) RN - 0 (Placebos) RN - 98PI200987 (Lidocaine) RN - K50XQU1029 (Nitrous Oxide) SB - D SB - IM MH - Adolescent MH - Adult MH - Analgesics/*therapeutic use MH - Anesthesia, Dental MH - Anesthetics, Inhalation/*therapeutic use MH - Anesthetics, Local/administration & dosage MH - Area Under Curve MH - Cross-Over Studies MH - Female MH - Humans MH - Lidocaine/administration & dosage MH - Male MH - Mandible/surgery MH - Molar, Third/surgery MH - Nitrous Oxide/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Patient Satisfaction MH - Placebos MH - *Premedication MH - Prospective Studies MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2004/12/08 09:00 MHDA- 2005/02/03 09:00 CRDT- 2004/12/08 09:00 PHST- 2004/12/08 09:00 [pubmed] PHST- 2005/02/03 09:00 [medline] PHST- 2004/12/08 09:00 [entrez] AID - S1079210404001878 [pii] AID - 10.1016/j.tripleo.2004.02.078 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):637-42. doi: 10.1016/j.tripleo.2004.02.078. PMID- 9331228 OWN - NLM STAT- MEDLINE DCOM- 19971030 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 55 IP - 10 DP - 1997 Oct TI - Amnestic and anxiolytic effects of alprazolam in oral surgery patients. PG - 1061-70 AB - PURPOSE: This study was designed to identify a dose of alprazolam that would reduce anxiety associated with oral surgery without causing accompanying memory impairment. PATIENTS AND METHODS: Thirty-six subjects in experiment 1 and 48 subjects in experiment 2 were pretested on a computerized memory battery to establish baseline performance. Subjects were then randomly assigned to receive placebo, 0.25 mg, or 0.75 mg oral alprazolam (experiment 1) or placebo, 0.25 mg, 0.50 mg, or 0.75 mg oral alprazolam (experiment 2). Forty-five minutes after the double-blind administration of alprazolam, subjects were given a second memory battery. The memory batteries tested story recall and recognition and word recall and recognition. Subjects in experiment 2 subsequently underwent oral surgery for the removal of one to four molars. The subjects completed anxiety questionnaires both before and after surgery. RESULTS: The 0.75-mg and 0.50-mg doses, but not the 0.25-mg dose, impaired word recall. The 0.75-mg dose also impaired story recall and recognition. The proportion of subjects reporting moderate to high anxiety during oral surgery decreased with increasing doses of alprazolam. Multiple regression indicated that the 0.75-mg alprazolam dose significantly decreased anxiety during oral surgery. The 0.25-mg and 0.50-mg doses also tended to reduce anxiety, but beta values for these doses did not reach significance. CONCLUSIONS: These findings indicate that alprazolam produces memory impairment at the dosages necessary to produce clinically significant anxiolysis during oral surgery. FAU - Coldwell, S E AU - Coldwell SE AD - University of Washington, Seattle 98195-7475, USA. FAU - Milgrom, P AU - Milgrom P FAU - Getz, T AU - Getz T FAU - Ramsay, D S AU - Ramsay DS LA - eng GR - DE00379/DE/NIDCR NIH HHS/United States GR - DE07132/DE/NIDCR NIH HHS/United States GR - DE10735/DE/NIDCR NIH HHS/United States GR - etc. PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Anxiety Agents) RN - 0 (Placebos) RN - YU55MQ3IZY (Alprazolam) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Alprazolam/administration & dosage/*therapeutic use MH - Analysis of Variance MH - Anti-Anxiety Agents/administration & dosage/*therapeutic use MH - Anxiety/prevention & control MH - Dental Anxiety/prevention & control MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Memory/*drug effects MH - Memory Disorders/chemically induced/prevention & control MH - Mental Recall/drug effects MH - Middle Aged MH - Molar/surgery MH - Molar, Third/surgery MH - Pain Measurement MH - Placebos MH - Regression Analysis MH - *Tooth Extraction EDAT- 1997/10/23 00:00 MHDA- 1997/10/23 00:01 CRDT- 1997/10/23 00:00 PHST- 1997/10/23 00:00 [pubmed] PHST- 1997/10/23 00:01 [medline] PHST- 1997/10/23 00:00 [entrez] AID - S0278-2391(97)90280-9 [pii] AID - 10.1016/s0278-2391(97)90280-9 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1997 Oct;55(10):1061-70. doi: 10.1016/s0278-2391(97)90280-9. PMID- 2020613 OWN - NLM STAT- MEDLINE DCOM- 19910530 LR - 20131121 IS - 0277-0008 (Print) IS - 0277-0008 (Linking) VI - 11 IP - 1 DP - 1991 TI - Evaluation of bromfenac, aspirin, and ibuprofen in postoperative oral surgery pain. PG - 64-70 AB - Two hundred forty-one outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive a single oral dose of bromfenac 5, 10, or 25 mg, aspirin 650 mg, ibuprofen 400 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief for 8 hours after medicating. Estimates of summed pain intensity difference, peak pain intensity difference, total relief, peak relief, and hours of 50% relief were derived from these subjective reports. All active treatments were significantly superior to placebo, and the slope of the dose-response curve for bromfenac was significant. Bromfenac 5 mg and aspirin 650 mg were equianalgesic; bromfenac 25 mg was slightly more efficacious than ibuprofen 400 mg. Bromfenac 25 mg and ibuprofen 400 mg were significantly superior to the other active treatments. Adverse effects were transient and consistent with the pharmacologic profiles of the medications evaluated. FAU - Forbes, J A AU - Forbes JA AD - Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Edquist, I A AU - Edquist IA FAU - Smith, F G AU - Smith FG FAU - Schwartz, M K AU - Schwartz MK FAU - Beaver, W T AU - Beaver WT LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 0 (Analgesics) RN - 0 (Benzophenones) RN - 0 (Bromobenzenes) RN - 864P0921DW (bromfenac) RN - R16CO5Y76E (Aspirin) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Analgesics/administration & dosage/*therapeutic use MH - Aspirin/administration & dosage/*therapeutic use MH - Benzophenones/administration & dosage/*therapeutic use MH - Bromobenzenes/administration & dosage/*therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Evaluation MH - Female MH - Humans MH - Ibuprofen/administration & dosage/*therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - *Pain Measurement MH - Pain, Postoperative/*drug therapy/surgery MH - Tooth, Impacted/surgery EDAT- 1991/01/01 00:00 MHDA- 1991/01/01 00:01 CRDT- 1991/01/01 00:00 PHST- 1991/01/01 00:00 [pubmed] PHST- 1991/01/01 00:01 [medline] PHST- 1991/01/01 00:00 [entrez] PST - ppublish SO - Pharmacotherapy. 1991;11(1):64-70. PMID- 7665721 OWN - NLM STAT- MEDLINE DCOM- 19951012 LR - 20190825 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 35 IP - 6 DP - 1995 Jun TI - A randomized, double-blind, placebo-controlled, dose-response study of the analgesic effect of lornoxicam after surgical removal of mandibular third molars. PG - 606-14 AB - The aim of the present study was to investigate the dose-effect relationship of single doses of 4 to 32 mg of lornoxicam (LNX), a new nonsteroidal antiinflammatory drug belonging to the oxicam group, compared with placebo and 10 mg ketorolac (KET) in the treatment of pain after oral surgery. Also, it was the aim of the study to evaluate the relationship between adverse events and different doses of LNX. After the surgical removal of a mandibular third molar, test medication was taken when the patients experienced at least moderate pain. After medication, pain relief, pain intensity, and any discomfort from the medication were noted in a questionnaire. Paracetamol was used as rescue medication. A total of 278 patients completed the study according to the protocol. The primary efficacy parameter was total pain relief after 6 hours, and all active treatments showed significantly better effect than placebo, with LNX 16 and 32 mg being significantly superior to LNX 4 mg. All other efficacy parameters showed the same dose-effect relationship. A total of 37 adverse events were reported evenly distributed in the 6 treatment groups; only 3 of these were considered severe, and all disappeared without treatment. In conclusion, the study showed a dose-effect relationship of LNX without a rise in adverse events. The effect of 10 mg KET seemed to be at the level of 8 to 16 mg LNX. FAU - Nørholt, S E AU - Nørholt SE AD - Department of Oral and Maxillofacial Surgery, Aarhus University, Denmark. FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S FAU - Bugge, C AU - Bugge C FAU - Branebjerg, P E AU - Branebjerg PE FAU - Ersbøll, B K AU - Ersbøll BK FAU - Bastian, H L AU - Bastian HL LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - D8K2JPN18B (Tolmetin) RN - ER09126G7A (lornoxicam) RN - YZI5105V0L (Ketorolac) SB - IM MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/*pharmacology/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology/therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Humans MH - Ketorolac MH - Mandible MH - Molar, Third/*surgery MH - Pain, Postoperative/drug therapy MH - Piroxicam/administration & dosage/*analogs & derivatives/pharmacology/therapeutic use MH - Tolmetin/administration & dosage/analogs & derivatives/pharmacology/therapeutic use MH - *Tooth Extraction EDAT- 1995/06/01 00:00 MHDA- 1995/06/01 00:01 CRDT- 1995/06/01 00:00 PHST- 1995/06/01 00:00 [pubmed] PHST- 1995/06/01 00:01 [medline] PHST- 1995/06/01 00:00 [entrez] AID - 10.1002/j.1552-4604.1995.tb05018.x [doi] PST - ppublish SO - J Clin Pharmacol. 1995 Jun;35(6):606-14. doi: 10.1002/j.1552-4604.1995.tb05018.x. PMID- 4217315 OWN - NLM STAT- MEDLINE DCOM- 19750509 LR - 20191030 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 3 IP - 6 DP - 1974 TI - Use of propylic ester of p-hydroxy-benzoic acid after removal of impacted mandibular third molars. PG - 394-9 FAU - Vedtofte, P AU - Vedtofte P FAU - Ritzau, M AU - Ritzau M FAU - Donatsky, O AU - Donatsky O LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Esters) RN - 0 (Hydroxybenzoates) RN - 0 (Placebos) SB - D SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Aged MH - Child MH - Clinical Trials as Topic MH - Dry Socket/*prevention & control MH - Esters MH - Female MH - Humans MH - Hydroxybenzoates/*therapeutic use MH - Male MH - Middle Aged MH - Molar/*surgery MH - Pericoronitis/complications MH - Placebos MH - Sex Factors MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1974/01/01 00:00 MHDA- 1974/01/01 00:01 CRDT- 1974/01/01 00:00 PHST- 1974/01/01 00:00 [pubmed] PHST- 1974/01/01 00:01 [medline] PHST- 1974/01/01 00:00 [entrez] AID - 10.1016/s0300-9785(74)80004-9 [doi] PST - ppublish SO - Int J Oral Surg. 1974;3(6):394-9. doi: 10.1016/s0300-9785(74)80004-9. PMID- 8364942 OWN - NLM STAT- MEDLINE DCOM- 19931004 LR - 20131121 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 15 IP - 3 DP - 1993 May-Jun TI - Pain relief after dental impaction surgery using ketorolac, hydrocodone plus acetaminophen, or placebo. PG - 500-9 AB - In a double-blind, placebo-controlled study, 207 patients with moderate pain after surgical removal of impacted third molars were randomly assigned to receive a single oral dose of 10 mg of ketorolac tromethamine, 10 mg of hydrocodone plus 1000 mg of acetaminophen, or placebo. Analgesic effect as assessed by summed pain intensity difference at 3 and 6 hours was significantly (P < or = 0.01) greater after ketorolac than after hydrocodone/acetaminophen. Total pain relief at 3 and 6 hours was significantly (P < 0.026) greater after ketorolac than after hydrocodone/acetaminophen or placebo. Patients taking hydrocodone/acetaminophen remedicated significantly (P = 0.027) sooner than those taking ketorolac. In this single-dose study, adverse events were reported more frequently by patients taking hydrocodone/acetaminophen than with ketorolac or placebo. It is concluded that, in this pain model, 10 mg of ketorolac affords better pain relief with fewer side effects than hydrocodone/acetaminophen. FAU - Fricke, J AU - Fricke J AD - Pharmaco-LSR, Austin, Texas. FAU - Halladay, S C AU - Halladay SC FAU - Bynum, L AU - Bynum L FAU - Francisco, C A AU - Francisco CA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Drug Combinations) RN - 023C2WHX2V (Tromethamine) RN - 362O9ITL9D (Acetaminophen) RN - 4EVE5946BQ (Ketorolac Tromethamine) RN - 6YKS4Y3WQ7 (Hydrocodone) RN - D8K2JPN18B (Tolmetin) SB - IM MH - Acetaminophen/adverse effects/*therapeutic use MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Hydrocodone/adverse effects/*therapeutic use MH - Ketorolac Tromethamine MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tolmetin/adverse effects/*analogs & derivatives/therapeutic use MH - Tooth, Impacted/*surgery MH - Tromethamine/adverse effects/*analogs & derivatives/therapeutic use EDAT- 1993/05/01 00:00 MHDA- 1993/05/01 00:01 CRDT- 1993/05/01 00:00 PHST- 1993/05/01 00:00 [pubmed] PHST- 1993/05/01 00:01 [medline] PHST- 1993/05/01 00:00 [entrez] PST - ppublish SO - Clin Ther. 1993 May-Jun;15(3):500-9. PMID- 11117655 OWN - NLM STAT- MEDLINE DCOM- 20010208 LR - 20190921 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 22 IP - 11 DP - 2000 Nov TI - Ibuprofen liquigel for oral surgery pain. PG - 1306-18 AB - BACKGROUND: Ibuprofen liquigel is a solubilized potassium ibuprofen 200-mg gelatin capsule formulation that was approved for over-the-counter use in 1995. OBJECTIVE: This study compared the analgesic efficacy and tolerability of ibuprofen liquigel 200 mg, ibuprofen liquigel 400 mg, acetaminophen caplets 1000 mg, and placebo in patients experiencing moderate or severe pain after surgical removal of impacted third molars. METHODS: This randomized, double-blind, parallel-group, 6-hour study was conducted in 210 patients experiencing moderate or severe postoperative pain. Ratings of pain intensity and pain relief were recorded every 15 minutes for the first hour, at 90 and 120 minutes, and then hourly through hour 6. The onsets of first perceptible relief and meaningful relief were recorded using 2 stopwatches. An analysis of variance model was employed to test for significant differences (P < or = 0.05) between treatment groups with respect to pain relief, pain intensity difference, total pain relief (TOTPAR), and summed pain intensity difference (SPID). Stopwatch measures were analyzed using the Cox proportional hazards model. Drug tolerability was assessed by monitoring the occurrence of adverse events. RESULTS: During the first 2 hours of the study (TOTPAR 2 and SPID 2), all active treatments were significantly more efficacious than placebo (P < 0.001), with ibuprofen liquigel 200 and 400 mg significantly more efficacious than acetaminophen 1000 mg (P < 0.05 and P < 0.01, respectively). For the entire duration of the study (TOTPAR 6 and SPID 6), only the 2 doses of ibuprofen liquigel were significantly more efficacious than placebo (P < 0.001). Ibuprofen liquigel 200 and 400 mg were also significantly more efficacious than acetaminophen 1000 mg on the summary measures TOTPAR 6 and SPID 6 (P < 0.01 and P < 0.001, respectively). Analysis of the stopwatch data revealed that all active treatments displayed significantly more rapid onsets to confirmed first perceptible relief (P < 0.001 to < 0.05) and meaningful relief (P < 0.001 to < 0.01) than did placebo, with ibuprofen liquigel 400 mg displaying a significantly more rapid onset to meaningful relief than acetaminophen 1000 mg (P < 0.05) and a significantly more rapid onset to confirmed first perceptible relief than acetaminophen 1000 mg (P < 0.001) and ibuprofen liquigel 200 mg (P < 0.01). All adverse events were considered mild or moderate, with an overall incidence of 11.5% in the ibuprofen liquigel 200-mg group, 6.8% in the ibuprofen liquigel 400-mg group, 19.0% in the acetaminophen 1000-mg group, and 25.9% in the placebo group. CONCLUSIONS: Ibuprofen liquigel provided greater peak and overall analgesic effects and a more rapid onset to analgesia than did acetaminophen 1000 mg. FAU - Hersh, E V AU - Hersh EV AD - University of Pennsylvania School of Dental Medicine, Philadelphia 19104-6003, USA. FAU - Levin, L M AU - Levin LM FAU - Cooper, S A AU - Cooper SA FAU - Doyle, G AU - Doyle G FAU - Waksman, J AU - Waksman J FAU - Wedell, D AU - Wedell D FAU - Hong, D AU - Hong D FAU - Secreto, S A AU - Secreto SA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Gels) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Acetaminophen/pharmacokinetics/*therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/*therapeutic use MH - Chemistry, Pharmaceutical MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Gels MH - Humans MH - Ibuprofen/pharmacokinetics/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Pain, Postoperative/*drug therapy/etiology MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 2000/12/16 11:00 MHDA- 2001/03/03 10:01 CRDT- 2000/12/16 11:00 PHST- 2000/12/16 11:00 [pubmed] PHST- 2001/03/03 10:01 [medline] PHST- 2000/12/16 11:00 [entrez] AID - S0149-2918(00)83027-1 [pii] AID - 10.1016/s0149-2918(00)83027-1 [doi] PST - ppublish SO - Clin Ther. 2000 Nov;22(11):1306-18. doi: 10.1016/s0149-2918(00)83027-1. PMID- 12966473 OWN - NLM STAT- MEDLINE DCOM- 20031007 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 61 IP - 9 DP - 2003 Sep TI - Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. PG - 997-1003 AB - PURPOSE: The therapeutic effects of glucocorticoids are generally attributed to suppression of multiple signaling pathways involved in the inflammatory response leading to decreased levels of inflammatory mediators at the site of injury. This study evaluated the in vivo relationship between levels of prostanoids at the site of tissue injury and analgesia after dexamethasone administration in a clinical model of tissue injury. METHODS: Subjects were administered dexamethasone 4 mg or placebo 12 hours and 1 hour before the removal of 2 mandibular third molars. A microdialysis probe was implanted at each surgical site for measurement of immunoreactive prostaglandin E2 (PGE(2)) or immunoreactive thromboxane B(2) (TxB(2)), and pain was measured concurrently. Subjects received either ketorolac 30 mg intravenously or placebo at pain onset. RESULTS: PGE(2) was detectable in the first postoperative sample, decreased over the next hour and then increased coincident with the onset of postoperative pain. Administration of dexamethasone suppressed PGE(2) levels in samples collected at pain onset in comparison to placebo and significantly suppressed TxB(2) at the surgical site but without any effect on pain report. Subsequent administration of ketorolac significantly reduced pain while decreasing both PGE(2) and TxB(2) levels at the surgical site. CONCLUSION: The lack of an analgesic effect for dexamethasone while reducing both PGE(2) and TxB(2) at the site of injury in comparison to ketorolac analgesia accompanied by greater reductions in levels of these prostanoids suggests that glucocorticoids at this dose do not suppress PGE(2) release sufficiently to attenuate peripheral sensitization of nociceptors after tissue injury. FAU - Dionne, Raymond A AU - Dionne RA AD - Pain and Naurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research/NIH, 10 Center Drive, Bethesda, MD 20892-2292, USA. rdionne@dir.nidcr.noh.gov FAU - Gordon, Sharon M AU - Gordon SM FAU - Rowan, Janet AU - Rowan J FAU - Kent, Allison AU - Kent A FAU - Brahim, Jaime S AU - Brahim JS LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 54397-85-2 (Thromboxane B2) RN - 7S5I7G3JQL (Dexamethasone) RN - K7Q1JQR04M (Dinoprostone) RN - YZI5105V0L (Ketorolac) SB - AIM SB - D SB - IM MH - Adult MH - Analgesia MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Dexamethasone/*administration & dosage MH - Dinoprostone/*antagonists & inhibitors MH - Double-Blind Method MH - Female MH - Humans MH - Ketorolac/*administration & dosage MH - Male MH - Mandible MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Postoperative Care MH - Preoperative Care MH - Prospective Studies MH - Thromboxane B2/*antagonists & inhibitors MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 2003/09/11 05:00 MHDA- 2003/10/08 05:00 CRDT- 2003/09/11 05:00 PHST- 2003/09/11 05:00 [pubmed] PHST- 2003/10/08 05:00 [medline] PHST- 2003/09/11 05:00 [entrez] AID - S0278239103003100 [pii] AID - 10.1016/s0278-2391(03)00310-0 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2003 Sep;61(9):997-1003. doi: 10.1016/s0278-2391(03)00310-0. PMID- 26845098 OWN - NLM STAT- MEDLINE DCOM- 20161101 LR - 20181202 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 27 IP - 2 DP - 2016 Mar TI - Does Vitamin D3 Have an Impact on Clinical and Biochemical Parameters Related to Third Molar Surgery. PG - 469-76 LID - 10.1097/SCS.0000000000002389 [doi] AB - The purpose of this study was to evaluate the clinical effect on the biochemical inflammatory markers of a single oral high dose of cholecalciferol in vitamin D-deficient patients undergoing the surgical removal of lower third molars.A randomized, split-mouth, single-blind study was conducted on 25 vitamin D-deficient patients ranging between 18 and 40 years of age requiring lower third molars extraction and referred at the Oral Surgery Unit of the School of Dentistry of the University of Messina.All patients, with vitamin D3 blood levels ≦30 ng/mL, underwent bilateral surgical removal. The first extraction (control group) being conducted with the administration of a placebo, the second one (test group) being conducted with the preliminary administration of 300,000 IU of cholecalciferol 4 days before the procedure.At each surgery, clinical indexes, such as pain, edema and any functional limitation have been recorded. Clinical and biochemical parameters were registered 4 days before, immediately after, 3 and 7 days after the surgical procedure. The data obtained were processed using paired t-test. The clinical outcome parameters showed a slight to moderate improvement between the control and the vitamin-D treatment group, with statistical significance being obtained regarding the edema at defined time points. Interleukin-1-beta, interleukin-6, and tumor necrosis factor-alpha values were significantly lower (P < 0.01) for the test group after the surgery. The increase of vitamin D serum levels showed an impact on the outcome of the third molar surgery, eliciting a reduced inflammatory response and leading to a more favorable clinical course. FAU - Oteri, Giacomo AU - Oteri G AD - *Department of Experimental Medical-Surgical Sciences and Dentistry †Department of Odontostomatology, School of Dentistry ‡Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. FAU - Cicciù, Marco AU - Cicciù M FAU - Peditto, Matteo AU - Peditto M FAU - Catalano, Antonino AU - Catalano A FAU - Loddo, Saverio AU - Loddo S FAU - Pisano, Michele AU - Pisano M FAU - Lasco, Antonino AU - Lasco A LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (IL6 protein, human) RN - 0 (Inflammation Mediators) RN - 0 (Interleukin-1) RN - 0 (Interleukin-6) RN - 0 (Placebos) RN - 0 (Tumor Necrosis Factor-alpha) RN - 0 (Vitamins) RN - 1C6V77QF41 (Cholecalciferol) SB - D MH - Administration, Oral MH - Adolescent MH - Adult MH - Cholecalciferol/deficiency/immunology/*therapeutic use MH - Edema/prevention & control MH - Female MH - Follow-Up Studies MH - Humans MH - Inflammation Mediators/*immunology MH - Interleukin-1/analysis MH - Interleukin-6/analysis MH - Male MH - Mandible/surgery MH - Molar, Third/*surgery MH - Pain, Postoperative/prevention & control MH - Placebos MH - Single-Blind Method MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Trismus/prevention & control MH - Tumor Necrosis Factor-alpha/drug effects MH - Vitamin D Deficiency/blood/*drug therapy MH - Vitamins/immunology/*therapeutic use MH - Young Adult EDAT- 2016/02/05 06:00 MHDA- 2016/11/02 06:00 CRDT- 2016/02/05 06:00 PHST- 2016/02/05 06:00 [entrez] PHST- 2016/02/05 06:00 [pubmed] PHST- 2016/11/02 06:00 [medline] AID - 10.1097/SCS.0000000000002389 [doi] PST - ppublish SO - J Craniofac Surg. 2016 Mar;27(2):469-76. doi: 10.1097/SCS.0000000000002389. PMID- 16981050 OWN - NLM STAT- MEDLINE DCOM- 20070503 LR - 20190606 IS - 0100-879X (Print) IS - 0100-879X (Linking) VI - 39 IP - 9 DP - 2006 Sep TI - Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery. PG - 1241-7 AB - Third molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxicam, 1 mg dexamethasone, 35 mg orphenadrine citrate, and 2.5 mg cyanocobalamin (Rheumazin) when compared with 20 mg piroxicam alone (Feldene) in mandibular third molar surgery. Eighty patients scheduled for removal of the third molar were included in this randomized and double-blind study. They received (vo) Rheumazin or Feldene 30 min after tooth extraction and once daily for 4 consecutive days. Pain was determined by a visual analogue scale and by the need for escape analgesia (paracetamol). Facial swelling was evaluated with a measuring tape and adverse effects and patient satisfaction were recorded. There was no statistically significant difference in facial swelling between Rheumazin and Feldene (control group). Both drugs were equally effective in the control of pain, with Rheumazin displaying less adverse effects than Feldene. Therefore, Rheumazin appears to provide a better risk/benefit ratio in the mandibular molar surgery. Since the side effects resulting from nonsteroidal anti-inflammatory drug administration are a severe limitation to the routine use of these drugs in clinical practice, our results suggest that Rheumazin can be a good choice for third molar removal treatment. FAU - Barroso, A B AU - Barroso AB AD - Unidade de Farmacologia Clínica, Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil. FAU - Lima, V AU - Lima V FAU - Guzzo, G C AU - Guzzo GC FAU - Moraes, R A AU - Moraes RA FAU - Vasconcellos, M C AU - Vasconcellos MC FAU - Bezerra, M M AU - Bezerra MM FAU - Viana, F A L AU - Viana FA FAU - Bezerra, R C R AU - Bezerra RC FAU - Santana, G S M AU - Santana GS FAU - Frota-Bezerra, F A AU - Frota-Bezerra FA FAU - Moraes, M O AU - Moraes MO FAU - Moraes, M E A AU - Moraes ME LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Brazil TA - Braz J Med Biol Res JT - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas JID - 8112917 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Muscle Relaxants, Central) RN - 12001-76-2 (Vitamin B Complex) RN - 13T4O6VMAM (Piroxicam) RN - 7S5I7G3JQL (Dexamethasone) RN - AL805O9OG9 (Orphenadrine) RN - P6YC3EG204 (Vitamin B 12) SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents/*administration & dosage/adverse effects MH - Dexamethasone/administration & dosage/adverse effects MH - Double-Blind Method MH - Drug Therapy, Combination MH - Edema/prevention & control MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/*surgery MH - Muscle Relaxants, Central/*administration & dosage/adverse effects MH - Orphenadrine/administration & dosage/adverse effects MH - Pain Measurement MH - Pain, Postoperative/drug therapy MH - Piroxicam/administration & dosage/adverse effects MH - Prospective Studies MH - Severity of Illness Index MH - *Tooth Extraction MH - Vitamin B 12/administration & dosage/adverse effects MH - Vitamin B Complex/*administration & dosage/adverse effects EDAT- 2006/09/19 09:00 MHDA- 2007/05/04 09:00 CRDT- 2006/09/19 09:00 PHST- 2005/11/29 00:00 [received] PHST- 2006/07/17 00:00 [accepted] PHST- 2006/09/19 09:00 [pubmed] PHST- 2007/05/04 09:00 [medline] PHST- 2006/09/19 09:00 [entrez] AID - S0100-879X2006000900012 [pii] AID - 10.1590/s0100-879x2006000900012 [doi] PST - ppublish SO - Braz J Med Biol Res. 2006 Sep;39(9):1241-7. doi: 10.1590/s0100-879x2006000900012. PMID- 20007794 OWN - NLM STAT- MEDLINE DCOM- 20100114 LR - 20181113 IS - 1471-6771 (Electronic) IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 104 IP - 1 DP - 2010 Jan TI - Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. PG - 80-8 LID - 10.1093/bja/aep338 [doi] AB - BACKGROUND: Acetaminophen is often used with a non-steriodal anti-inflammatory drug for acute pain. Hitherto, these drugs have had to be given separately, typically at different time intervals. Maxigesic tablets combine acetaminophen and ibuprofen in clinically appropriate doses to simplify administration and dosage regimen. We compared this combination with each of the constituent drugs for the relief of pain after extraction of third molar teeth. METHODS: Adults (more than 16 yr) having one or more wisdom teeth removed under general or local anaesthesia were instructed to take two tablets before operation, then two tablets every 6 h for up to 48 h of: (i) a combination of acetaminophen 500 mg and ibuprofen 150 mg per tablet (Maxigesic); (ii) acetaminophen 500 mg per tablet alone; or (iii) ibuprofen 150 mg per tablet alone. The primary outcome measure was the area under the curve (AUC) of the 100 mm visual analogue scale pain measurements taken for up to 48 h after surgery, divided by time, at rest and on activity. Pharmacokinetic data were collected in a subset of patients. RESULTS: The mean (sem) time-corrected AUC on rest and activity, respectively, were: combination group 22.3 (3.2) and 28.4 (3.4); acetaminophen group 33.0 (3.1) and 40.4 (3.3); and ibuprofen group 34.8 (3.2) and 40.2 (3.4); P<0.01 for each of the four comparisons of combination vs constituent drug. There was no pharmacokinetic interaction between acetaminophen and ibuprofen administered together. CONCLUSIONS: Maxigesic tablets provide superior pain relief after oral surgery to acetaminophen or ibuprofen alone. FAU - Merry, A F AU - Merry AF AD - Department of Anaesthesiology, University of Auckland, Private Bag 92019, Auckland, New Zealand. a.merry@auckland.ac.nz FAU - Gibbs, R D AU - Gibbs RD FAU - Edwards, J AU - Edwards J FAU - Ting, G S AU - Ting GS FAU - Frampton, C AU - Frampton C FAU - Davies, E AU - Davies E FAU - Anderson, B J AU - Anderson BJ LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - IM CIN - Br J Anaesth. 2010 May;104(5):657-9. PMID: 20400613 MH - Acetaminophen/adverse effects/blood/*therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/adverse effects/blood/*therapeutic use MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/adverse effects/blood/*therapeutic use MH - Male MH - Molar, Third/surgery MH - Pain Measurement/methods MH - Pain, Postoperative/blood/etiology/*prevention & control MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Young Adult PMC - PMC2791549 EDAT- 2009/12/17 06:00 MHDA- 2010/01/15 06:00 CRDT- 2009/12/17 06:00 PHST- 2009/12/17 06:00 [entrez] PHST- 2009/12/17 06:00 [pubmed] PHST- 2010/01/15 06:00 [medline] AID - S0007-0912(17)33711-X [pii] AID - aep338 [pii] AID - 10.1093/bja/aep338 [doi] PST - ppublish SO - Br J Anaesth. 2010 Jan;104(1):80-8. doi: 10.1093/bja/aep338. PMID- 21884146 OWN - NLM STAT- MEDLINE DCOM- 20120126 LR - 20131121 IS - 1834-7819 (Electronic) IS - 0045-0421 (Linking) VI - 56 IP - 3 DP - 2011 Sep TI - Inhaled methoxyflurane (Penthrox) sedation for third molar extraction: a comparison to nitrous oxide sedation. PG - 296-301 LID - 10.1111/j.1834-7819.2011.01350.x [doi] AB - BACKGROUND: The aim of this study was to evaluate the use of inhaled methoxyflurane (Penthrox) in the reduction of dental anxiety in patients undergoing mandibular third molar removal in a specialist surgical suite and compare it to the conventional nitrous oxide sedation. METHODS: A prospective randomized, non-blinded crossover design study of 20 patients receiving two types of sedation for their third molar extraction who participated in 40 treatment sessions. At first appointment, a patient was randomly assigned to receive either nitrous oxide sedation or intermittent Penthrox inhaler sedation, with the alternate regimen administered during the second appointment. Peri-procedural vital signs (heart rate and blood pressure) were recorded and any deviations from 20% from the baseline values, as well as any drop in oxygen saturation below 92% were documented. The Ramsay Sedation Scale (RSS) score was recorded every five minutes. Patient cooperation during the procedure, patients' general opinion about the sedation technique, surgeon satisfaction and the occurrence of side effects were all recorded. After the second procedure, the patient was also asked if he or she had any preference of one sedation technique over the other. RESULTS: Levels of sedation were comparable in nitrous oxide and Penthrox sedation sessions. However, at 15 minutes of sedation it was significantly lighter (p < 0.05) in Penthrox. No patient in both regimens reached a RSS deeper than a score of 4. Parameters measured for assessment of sedation (patient cooperation, surgeon satisfaction and patient general opinion about sedation technique) were all similarly comparable for both nitrous oxide and Penthrox. In both sedation sessions, the odour of the inhalational agent was accepted by the patients; half of the patients (10 patients) who received methoxyflurane thought its odour was pleasant. Patients preferred methoxyflurane (Penthrox) inhalation over nitrous oxide sedation (Fisher's Exact test, p < 0.05). Adverse events were minimal. No patient was either deeply sedated or agitated. Blood pressure was within ± 20% from the baseline values. No patient had oxygen saturation less than 92%. Dizziness was the most frequently encountered side effect in both regimens (four patients each). Two patients had bradycardia (HR < 60 beats/minute) when nitrous oxide was used in comparison to one patient with Penthrox sedation. Paraesthesia of fingers and heaviness of the chest was encountered only with nitrous oxide sedation (four patients). Mild self-limited shivering occurred in one patient with Penthrox sedation. CONCLUSIONS: The Penthrox Inhaler can produce a comparable sedation to that of nitrous oxide for the surgical extraction of third molars under local anaesthesia. CI - © 2011 Australian Dental Association. FAU - Abdullah, W A AU - Abdullah WA AD - Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. drwaleedsurgery@yahoo.com FAU - Sheta, S A AU - Sheta SA FAU - Nooh, N S AU - Nooh NS LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Australia TA - Aust Dent J JT - Australian dental journal JID - 0370612 RN - 0 (Anesthetics, Inhalation) RN - 30905R8O7B (Methoxyflurane) RN - K50XQU1029 (Nitrous Oxide) RN - S88TT14065 (Oxygen) SB - D SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/methods MH - Anesthetics, Inhalation/*administration & dosage/adverse effects MH - Blood Pressure/physiology MH - Bradycardia/chemically induced MH - Conscious Sedation/*methods MH - Cooperative Behavior MH - Cross-Over Studies MH - Dental Anxiety/prevention & control MH - Dizziness/chemically induced MH - Female MH - Fingers MH - Heart Rate/physiology MH - Humans MH - Male MH - Methoxyflurane/*administration & dosage/adverse effects MH - Molar, Third/*surgery MH - Nausea/chemically induced MH - Nitrous Oxide/*administration & dosage/adverse effects MH - Oxygen/blood MH - Paresthesia/chemically induced MH - Patient Satisfaction MH - Prospective Studies MH - Thorax/drug effects MH - *Tooth Extraction MH - Treatment Outcome MH - Young Adult EDAT- 2011/09/03 06:00 MHDA- 2012/01/27 06:00 CRDT- 2011/09/03 06:00 PHST- 2011/09/03 06:00 [entrez] PHST- 2011/09/03 06:00 [pubmed] PHST- 2012/01/27 06:00 [medline] AID - 10.1111/j.1834-7819.2011.01350.x [doi] PST - ppublish SO - Aust Dent J. 2011 Sep;56(3):296-301. doi: 10.1111/j.1834-7819.2011.01350.x. PMID- 9226386 OWN - NLM STAT- MEDLINE DCOM- 19970815 LR - 20190831 IS - 0303-6979 (Print) IS - 0303-6979 (Linking) VI - 24 IP - 7 DP - 1997 Jul TI - Treatment of 3rd molar-induced periodontal defects with guided tissue regeneration. PG - 464-9 AB - Recent reports provide evidence of increased attachment levels when using guided tissue regeneration (GTR) techniques for the treatment of periodontal defects. Periodontal defects frequently occur at the distal aspect of mandibular 2nd molars which are next to mesioangular impacted 3rd molars that have oral communication. The purpose of this study was to determine whether the use of GTR can enhance probing attachment levels (PALs) following extraction of mesioangular impacted third molars. 12 patients with bilateral soft tissue impacted mandibular 3rd molars entered this split mouth study. After extractions, the previously exposed distal root surface of the 2nd molars were debrided. The defects on the randomly selected experimental sites were covered with expanded polytetraflouro-ethylene (e-PTFE) membrane and the tissue was replaced to cover the membrane. Membranes were removed after 6 weeks. Control sites were treated identically except no membrane was placed. GI, P1I, PD, PAL and BOP records were obtained at 0, 3 and 6 months. The use of barrier material did not provide statistically-significant differences in PAL when comparing experimental versus control sites. Nevertheless, PAL gain was consistently greater at 3 and 6 months when GTR techniques were used in sites with deep impactions. FAU - Oxford, G E AU - Oxford GE AD - University of Florida College of Medicine, Department of Oral Biology, Gainesville 32610-0424, USA. FAU - Quintero, G AU - Quintero G FAU - Stuller, C B AU - Stuller CB FAU - Gher, M E AU - Gher ME LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 RN - 0 (Membranes, Artificial) SB - D SB - IM MH - Adult MH - Alveolar Bone Loss/*etiology/*surgery MH - Dental Plaque Index MH - *Guided Tissue Regeneration, Periodontal MH - Humans MH - Mandible MH - Membranes, Artificial MH - *Molar, Third MH - Periodontal Attachment Loss/etiology/surgery MH - Periodontal Index MH - Tooth Extraction MH - Tooth, Impacted/*complications/surgery MH - Treatment Outcome EDAT- 1997/07/01 00:00 MHDA- 1997/07/01 00:01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/07/01 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] AID - 10.1111/j.1600-051x.1997.tb00213.x [doi] PST - ppublish SO - J Clin Periodontol. 1997 Jul;24(7):464-9. doi: 10.1111/j.1600-051x.1997.tb00213.x. PMID- 16243175 OWN - NLM STAT- MEDLINE DCOM- 20051201 LR - 20131121 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 63 IP - 11 DP - 2005 Nov TI - Microbial analysis of the autogenous bone collected by bone filter during oral surgery: a clinical study. PG - 1593-8 AB - PURPOSE: The purposes of the study presented are to identify the microbial content of the collected bone debris and to determine the antibacterial efficiency of chlorhexidine mouth rinse in reducing the microbial content of the collected bone debris. PATIENTS AND METHODS: Twenty-five patients who had asymptomatic fully impacted mandibular third molars bilaterally underwent surgical removal for prophylactic and orthodontic considerations. Immediately before surgery all patients rinsed with 10 mL of their assigned solution (chlorhexidine or sterile saline) for 2 minutes. Before surgical removal of the teeth, bone debris was collected with a stringent aspiration protocol from the ramus by bone filter. The microbial content of the bone debris was assessed and the bacterial levels between the 2 groups were compared statistically. RESULTS: All samples from both groups (chlorhexidine or sterile saline) yielded viable microorganisms. There was no significant difference between the mean/median colony-forming units (CFU)/g values of both group samples, for aerobes (Streptococcus salivarius) and anaerobes (Bacteroides, Peptococcus, Peptostreptococcus, and Veillonella species). With regard to total microorganisms, the mean CFU/g derived from the chlorhexidine group samples were 1.5 x 10(8) CFU/g per bone sample compared with 1.5 x 10(9) CFU/g for the sterile saline control group (P < .05). CONCLUSION: Although chlorhexidine rinsing immediately before surgery reduced the levels of total microorganisms when compared with stringent aspiration protocol alone, it has not been found effective on aerobic Streptococcus salivarius and, importantly, on anaerobes. The reduced bacterial levels may still carry high infectious risk and may lead to failure in autogenous grafting procedures in oral surgery. FAU - Kürkçü, Mehmet AU - Kürkçü M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, 01330 Balcali, Adana, Turkey. kurkcu@cu.edu.tr FAU - Oz, I Attila AU - Oz IA FAU - Köksal, Fatih AU - Köksal F FAU - Benlidayi, M Emre AU - Benlidayi ME FAU - Güneşli, Aylin AU - Güneşli A LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Mouthwashes) RN - R4KO0DY52L (Chlorhexidine) SB - AIM SB - D SB - IM MH - Adolescent MH - Adult MH - Anti-Infective Agents, Local/administration & dosage/*therapeutic use MH - Antibiotic Prophylaxis/methods MH - Bacteria, Anaerobic/*drug effects MH - Bacteroides/drug effects MH - Chlorhexidine/administration & dosage/*therapeutic use MH - Colony Count, Microbial MH - Cross-Over Studies MH - Equipment Contamination/prevention & control MH - Female MH - Filtration MH - Humans MH - Male MH - Mandible/*microbiology/surgery MH - Molar, Third/surgery MH - Mouthwashes/therapeutic use MH - Peptococcus/drug effects MH - Peptostreptococcus/drug effects MH - Prospective Studies MH - Reference Values MH - Streptococcus/*drug effects MH - Tooth Extraction MH - Treatment Outcome MH - Veillonella/drug effects EDAT- 2005/10/26 09:00 MHDA- 2005/12/13 09:00 CRDT- 2005/10/26 09:00 PHST- 2005/10/26 09:00 [pubmed] PHST- 2005/12/13 09:00 [medline] PHST- 2005/10/26 09:00 [entrez] AID - S0278-2391(05)01223-1 [pii] AID - 10.1016/j.joms.2005.07.016 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2005 Nov;63(11):1593-8. doi: 10.1016/j.joms.2005.07.016. PMID- 10847537 OWN - NLM STAT- MEDLINE DCOM- 20000928 LR - 20190831 IS - 0303-6979 (Print) IS - 0303-6979 (Linking) VI - 27 IP - 5 DP - 2000 May TI - Healing following GTR treatment of intrabony defects distal to mandibular 2nd molars using resorbable and non-resorbable barriers. PG - 333-40 AB - AIMS: The objectives of the present, randomised clinical trial were (i) to evaluate the healing of periodontal intrabony defects at the distal aspect of mandibular 2nd molars using a resorbable polylactic acid (PLA) barrier and a non-resorbable polytetrafluoroethylene (e-PTFE) barrier and (ii) to compare the therapeutic effect of the bioresorbable versus the non-resorbable barrier. METHOD: 19 patients with intrabony defects distal to mandibular 2nd molars > or = 4 mm (on radiographs) were included in the study. The defects all remained 5 years after surgical removal of impacted 3rd molars. Following flap elevation and defect debridement, the defects were randomly covered with, either a resorbable PLA or a non-resorbable e-PTFE barrier. Flaps were repositioned and sutured to completely cover the barriers. Treatment was evaluated clinically after 1 year by measurements of probing depth (PD), probing attachment level (PAL), and probing bone level (PBL) and radiographically by measurements of bone levels on computer digitised images of radiographs taken immediately before and 1 year postsurgery. RESULTS: Both treatments resulted in significant PD reduction, PAL gain, and bone fill. The total PD reduction was 5.3 +/- 1.9 mm for the PLA treated sites and 3.7 +/- 1.7 mm for the e-PTFE treated sites (p<0.05). The corresponding values for PAL gain were 4.7 +/- 0.7 mm and 3.6 +/- 1.7 mm (p<0.05) and for PBL gain 5.1 +/- 1.2 and 3.3 +/- 2.0 mm (p<0.05). Radiographic bone fill averaged 3.4 +/- 1.2 for the PLA and 2.0 +/- 1.6 mm for the e-PTFE barriers (p<0.05). Radiographic bone level measurements were significantly smaller than the corresponding clinical measurements, indicating that radiographs tend to underestimate bone fill. CONCLUSIONS: GTR treatment of deep intrabony defects distal to mandibular second molars using resorbable PLA barriers resulted in significant PD reduction, PAL gain and bone fill at least equivalent to the results obtained using non-resorbable e-PTFE barriers. FAU - Karapataki, S AU - Karapataki S AD - Department of Periodontology, The Institute for Postgraduate Dental Education, Jönköping, Sweden. FAU - Hugoson, A AU - Hugoson A FAU - Falk, H AU - Falk H FAU - Laurell, L AU - Laurell L FAU - Kugelberg, C F AU - Kugelberg CF LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 RN - 0 (Membranes, Artificial) RN - 0 (Polyesters) RN - 0 (Polymers) RN - 33X04XA5AT (Lactic Acid) RN - 459TN2L5F5 (poly(lactide)) RN - 9002-84-0 (Polytetrafluoroethylene) SB - D SB - IM MH - Adult MH - Alveolar Bone Loss/diagnostic imaging/etiology/*surgery MH - Analysis of Variance MH - *Bone Regeneration MH - Dental Plaque Index MH - Guided Tissue Regeneration, Periodontal/*methods MH - Humans MH - Lactic Acid MH - Mandible MH - *Membranes, Artificial MH - Molar, Third/surgery MH - Periodontal Index MH - Polyesters MH - Polymers MH - Polytetrafluoroethylene MH - Radiography MH - Regression Analysis MH - Statistics, Nonparametric MH - Tooth Extraction/adverse effects MH - Treatment Outcome MH - Wound Healing EDAT- 2000/06/10 09:00 MHDA- 2000/09/30 11:01 CRDT- 2000/06/10 09:00 PHST- 2000/06/10 09:00 [pubmed] PHST- 2000/09/30 11:01 [medline] PHST- 2000/06/10 09:00 [entrez] AID - 10.1034/j.1600-051x.2000.027005333.x [doi] PST - ppublish SO - J Clin Periodontol. 2000 May;27(5):333-40. doi: 10.1034/j.1600-051x.2000.027005333.x. PMID- 7672875 OWN - NLM STAT- MEDLINE DCOM- 19951017 LR - 20151119 IS - 0251-1649 (Print) IS - 0251-1649 (Linking) VI - 14 IP - 5-6 DP - 1994 TI - Evaluation of piroxicam-beta-cyclodextrin, piroxicam, paracetamol and placebo in post-operative oral surgery pain. PG - 185-91 AB - Two hundred ninety-eight patients with post-operative pain after the surgical removal of an impacted third molar were randomly assigned, on a double-blind basis, to receive a single oral dose of piroxicam 20 mg, or piroxicam-beta-cyclodextrin equivalent to 20 mg piroxicam, or paracetamol 500 mg, or placebo. Using a semi-quantitative self-rating scale, patients rated their pain and its relief at 30-min intervals for the first 2 h, and then hourly for 4 h after treatment administration. All active medications were reported to be significantly superior to placebo. The three active drugs were comparable for the degree of analgesia up to the third hour, after which the effect of paracetamol decreased significantly as compared to piroxicam-beta-cyclodextrin and piroxicam. Piroxicam-beta-cyclodextrin and paracetamol were more rapid than piroxicam in inducing analgesia. The tolerability for the active drugs was comparable to that for placebo. FAU - Dolci, G AU - Dolci G AD - Odontoiatric Clinic, La Sapienza University, Rome, Italy. FAU - Ripari, M AU - Ripari M FAU - Pacifici, L AU - Pacifici L FAU - Umile, A AU - Umile A LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Switzerland TA - Int J Clin Pharmacol Res JT - International journal of clinical pharmacology research JID - 8110183 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclodextrins) RN - 0 (Drug Combinations) RN - 0 (Food Additives) RN - 0 (beta-Cyclodextrins) RN - 13T4O6VMAM (Piroxicam) RN - 362O9ITL9D (Acetaminophen) RN - 96684-39-8 (piroxicam-beta-cyclodextrin) SB - IM MH - Acetaminophen/administration & dosage/pharmacology/*therapeutic use MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/pharmacology/*therapeutic use MH - Cyclodextrins/administration & dosage/pharmacology/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Food Additives/administration & dosage/pharmacology/therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain, Postoperative/*drug therapy/etiology MH - Piroxicam/administration & dosage/pharmacology/*therapeutic use MH - Surgery, Oral MH - Surveys and Questionnaires MH - Tooth Extraction/adverse effects MH - *beta-Cyclodextrins EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] PST - ppublish SO - Int J Clin Pharmacol Res. 1994;14(5-6):185-91. PMID- 32591869 OWN - NLM STAT- MEDLINE DCOM- 20210215 LR - 20210215 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 25 IP - 3 DP - 2021 Mar TI - Alveolar ridge dimensional changes after two socket sealing techniques. A pilot randomized clinical trial. PG - 1235-1243 LID - 10.1007/s00784-020-03428-9 [doi] AB - OBJECTIVES: This pilot study aimed to assess dimensional changes following two different alveolar socket sealing techniques. MATERIAL AND METHODS: Twenty-one patients requiring tooth extraction and implant placement were randomly allocated to two different alveolar ridge preservation techniques. In the control group, demineralized bovine bone mineral (DBBM) and a gingival soft tissue punch were used to fill and seal the socket, whereas in the test group, the extraction socket was filled with DBBM and sealed with a hemostatic gelatin sponge. Digitalized impressions were taken before and 6 months after tooth extraction. The comparison was made on horizontal and vertical dimensional changes. RESULTS: The mean vertical loss was 0.8 ± 0.6 mm for the control group and 0.7 ± 0.5 mm for the test one. No statistical difference was found between groups for the vertical shrinkage. The horizontal dimensional narrowing of the alveolar socket was respectively 7.1/4.0/2.5 mm at levels 1, 3, and 5 mm from a coronal reference level for the control group. The test group showed dimensional changes of 4.8/2.3/1.3 mm at the three different levels, respectively. A significant difference was found at levels 3 and 5 mm. Referring to a visual analog pain scale, patients reported more severe pain in the control group (5.7/10) when compared with the test group (2.8/10). The difference was statistically highly significant (P ≤ 0.001). CONCLUSIONS: A significant difference was found between control and test groups regarding the horizontal dimensional changes and the post-operative pain. CLINICAL RELEVANCE: Regarding this primary result, the socket sealing technique with a hemostatic sponge provides an effective and inexpensive protocol with less post-operative pain. FAU - Debel, M AU - Debel M AUID- ORCID: 0000-0001-9457-4950 AD - Department of Periodontology, Université Catholique de Louvain (UCL)-Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium. maxim.debel@gmail.com. FAU - Toma, S AU - Toma S AD - Department of Periodontology, Université Catholique de Louvain (UCL)-Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium. FAU - Vandenberghe, B AU - Vandenberghe B AD - Advimago, Center for Advanced Oral Imaging, Rue Emile Claus 42, 1050, Brussels, Belgium. FAU - Brecx, M C AU - Brecx MC AD - Department of Periodontology, Université Catholique de Louvain (UCL)-Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium. FAU - Lasserre, J F AU - Lasserre JF AD - Department of Periodontology, Université Catholique de Louvain (UCL)-Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200626 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - D MH - *Alveolar Bone Loss/prevention & control MH - Alveolar Process/surgery MH - *Alveolar Ridge Augmentation MH - Animals MH - Cattle MH - Gingiva MH - Humans MH - Pilot Projects MH - Tooth Extraction MH - Tooth Socket/surgery OTO - NOTNLM OT - Alveolar ridge preservation OT - Bone substitute OT - Extraction OT - Socket sealing OT - Soft tissue management EDAT- 2020/06/28 06:00 MHDA- 2021/02/16 06:00 CRDT- 2020/06/28 06:00 PHST- 2019/07/29 00:00 [received] PHST- 2020/06/22 00:00 [accepted] PHST- 2020/06/28 06:00 [pubmed] PHST- 2021/02/16 06:00 [medline] PHST- 2020/06/28 06:00 [entrez] AID - 10.1007/s00784-020-03428-9 [pii] AID - 10.1007/s00784-020-03428-9 [doi] PST - ppublish SO - Clin Oral Investig. 2021 Mar;25(3):1235-1243. doi: 10.1007/s00784-020-03428-9. Epub 2020 Jun 26. PMID- 11021731 OWN - NLM STAT- MEDLINE DCOM- 20001017 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 58 IP - 10 Suppl 2 DP - 2000 Oct TI - Analgesic efficacy of intranasal butorphanol (Stadol NS) in the treatment of pain after dental impaction surgery. PG - 19-26 AB - PURPOSE: This study evaluated the safety and efficacy of increasing doses of intranasal butorphanol (Stadol NS, Bristol-Myers Squibb, New York, NY) compared with placebo in controlling moderate to severe pain after removal of bony impacted third molars. PATIENTS AND METHODS: This single-dose, double-blind, parallel-group, dose-response trial compared the efficacy and safety of 4 doses of intranasally administered butorphanol tartrate and placebo in controlling moderate to severe pain after the removal of impacted third molars in 151 patients. The study was conducted at 2 sites. The patients were randomly assigned to receive 1 dose of butorphanol tartrate: 0.25 mg (n = 31), 0.5 mg (n = 29), 1.0 mg (n = 30), 2.0 mg (n = 30), or placebo (n = 31). Medication was administered with a metered-dose spray pump. Patients rated pain intensity (PI), pain relief (PAR), pain half gone (PHG), and adverse events at 0.25, 0.5, 1, 2, 3, 4, 5, and 6 hours after treatment. At the end of the study period or before rescue medication (ibuprofen, 400 mg, or acetaminophen, 1,000 mg), patients provided an overall assessment (GLOBAL). RESULTS: A linear dose-response regression (P < or = .05) was observed for the means of pain intensity difference (PID), PAR, and PHG at 0.25, 0.5, and 1 hour, and for sum of pain intensity differences (SPID), sum of pain relief (TOTPAR), peak PID and PAR, and GLOBAL evaluation. The 1.0- and 2.0-mg groups experienced greater pain relief compared with placebo (P = .05) during the first hour after drug administration. The 1.0- and 2.0-mg groups had significantly better GLOBAL evaluations than the placebo group, but were not significantly different from placebo for time until remedication (TREMED). Incidence and severity of the most common adverse events were dose-related. Two severe adverse events (drowsiness and dizziness) occurred after the 2.0-mg dose. CONCLUSION: Intranasal butorphanol effectively relieved postsurgical dental pain, with a rapid onset within 15 minutes, and seems to be a promising addition to the current armamentarium of opioid analgesics. As with other opioids, it should be used cautiously in an outpatient setting. FAU - Desjardins, P J AU - Desjardins PJ AD - University of Medicine and Dentistry New Jersey, NJ Dental School, Newark, USA. pdesjardins@scirex.com FAU - Norris, L H AU - Norris LH FAU - Cooper, S A AU - Cooper SA FAU - Reynolds, D C AU - Reynolds DC LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Analgesics, Opioid) RN - QV897JC36D (Butorphanol) SB - AIM SB - D SB - IM MH - Administration, Inhalation MH - Adolescent MH - Adult MH - Analgesia/methods/statistics & numerical data MH - Analgesics, Opioid/*administration & dosage/adverse effects MH - Butorphanol/*administration & dosage/adverse effects MH - Dose-Response Relationship, Drug MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Pain Measurement/methods/statistics & numerical data MH - Pain, Postoperative/*drug therapy MH - Safety MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 2000/10/06 11:00 MHDA- 2000/10/21 11:01 CRDT- 2000/10/06 11:00 PHST- 2000/10/06 11:00 [pubmed] PHST- 2000/10/21 11:01 [medline] PHST- 2000/10/06 11:00 [entrez] AID - S0278-2391(00)00360-8 [pii] AID - 10.1053/joms.2000.17884 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2000 Oct;58(10 Suppl 2):19-26. doi: 10.1053/joms.2000.17884. PMID- 10914173 OWN - NLM STAT- MEDLINE DCOM- 20000906 LR - 20131121 IS - 0017-7768 (Print) IS - 0017-7768 (Linking) VI - 136 IP - 2 DP - 1999 Jan 15 TI - [Ambulatory oral procedures in patients on low-dose aspirin]. PG - 108-10, 175 AB - Discontinuation of long-term, low-dose aspirin prior to ambulatory oral surgical procedures was assessed in a blind, controlled prospective study. 50 patients on low-dose aspirin who needed dental extractions, periodontal surgery, or other ambulatory oral surgery were randomly divided into test and control groups. The control patients stopped taking aspirin a week before operation, but in the test group aspirin was continued. Before, during and after surgery bleeding time was tested. Although bleeding time was significantly longer when aspirin was continued, in both groups it was within normal limits. Intraoperative hemorrhage was more frequent in those taking aspirin. Hemostasis control posed no problem and there were no postoperative complications in either group. It is concluded that discontinuing low-dose aspirin prior to elective oral surgery is not justified. FAU - Gaspar, R AU - Gaspar R AD - Dept. of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa. FAU - Ardekian, L AU - Ardekian L FAU - Brenner, B AU - Brenner B FAU - Peled, M AU - Peled M FAU - Laufer, D AU - Laufer D LA - heb PT - Clinical Trial PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial PL - Israel TA - Harefuah JT - Harefuah JID - 0034351 RN - 0 (Platelet Aggregation Inhibitors) RN - R16CO5Y76E (Aspirin) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - *Ambulatory Surgical Procedures MH - Aspirin/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Oral Surgical Procedures MH - Periodontal Diseases/surgery MH - Platelet Aggregation Inhibitors/*therapeutic use MH - Tooth Extraction EDAT- 2000/07/29 11:00 MHDA- 2000/09/09 11:01 CRDT- 2000/07/29 11:00 PHST- 2000/07/29 11:00 [pubmed] PHST- 2000/09/09 11:01 [medline] PHST- 2000/07/29 11:00 [entrez] PST - ppublish SO - Harefuah. 1999 Jan 15;136(2):108-10, 175. PMID- 4575496 OWN - NLM STAT- MEDLINE DCOM- 19730806 LR - 20131121 IS - 0039-6745 (Print) IS - 0039-6745 (Linking) VI - 66 IP - 2 DP - 1973 Mar TI - Apernyl as alveolar inlay in connection with the removal of impacted third molars of the lower jaw. A clinical double blind investigation of 100 patients. PG - 197-200 FAU - Kjellman, O AU - Kjellman O LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Sweden TA - Sven Tandlak Tidskr JT - Svensk tandlakare tidskrift. Swedish dental journal JID - 7708466 RN - 0 (Placebos) RN - 0 (Tablets) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Adolescent MH - Adult MH - Aspirin/*administration & dosage/therapeutic use MH - Clinical Trials as Topic MH - Dry Socket MH - Female MH - Hematoma MH - Humans MH - Male MH - Mandible MH - Middle Aged MH - Molar/surgery MH - Oral Hemorrhage MH - Pain/*drug therapy MH - Placebos MH - Tablets MH - *Tooth Extraction EDAT- 1973/03/01 00:00 MHDA- 1973/03/01 00:01 CRDT- 1973/03/01 00:00 PHST- 1973/03/01 00:00 [pubmed] PHST- 1973/03/01 00:01 [medline] PHST- 1973/03/01 00:00 [entrez] PST - ppublish SO - Sven Tandlak Tidskr. 1973 Mar;66(2):197-200. PMID- 7004258 OWN - NLM STAT- MEDLINE DCOM- 19810219 LR - 20190703 IS - 0003-2409 (Print) IS - 0003-2409 (Linking) VI - 35 IP - 8 DP - 1980 Aug TI - Metoprolol in anaesthesia for oral surgery. The effect of pretreatment on the incidence of cardiac dysrhythmias. PG - 779-82 AB - Metoprolol, a cardioselective beta-adrenergic blocking drug, was given, with a placebo as an alternative, in a double-blind trial to 60 patients who were undergoing removal of third molar teeth under general anaesthesia. Dyshythmias occurred in significantly fewer patients in the metoprolol group than in the control group, and when ventricular dyshythmias occurred they were abolished in every case by the administration of metoprolol. It is concluded that metoprolol is effective in preventing cardiac dysrhythmias occurring during oral surgery carried out under general anaesthesia. FAU - Whitehead, M H AU - Whitehead MH FAU - Whitmarsh, V B AU - Whitmarsh VB FAU - Horton, J N AU - Horton JN LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Anaesthesia JT - Anaesthesia JID - 0370524 RN - 0 (Placebos) RN - 0 (Propanolamines) RN - GEB06NHM23 (Metoprolol) SB - AIM SB - IM MH - Adolescent MH - Adult MH - Anesthesia, Dental/adverse effects MH - Anesthesia, General/adverse effects MH - Arrhythmias, Cardiac/etiology/*prevention & control MH - Clinical Trials as Topic MH - Double-Blind Method MH - Hemodynamics/drug effects MH - Humans MH - Metoprolol/*therapeutic use MH - Middle Aged MH - Placebos MH - *Premedication MH - Propanolamines/*therapeutic use MH - *Tooth Extraction EDAT- 1980/08/01 00:00 MHDA- 1980/08/01 00:01 CRDT- 1980/08/01 00:00 PHST- 1980/08/01 00:00 [pubmed] PHST- 1980/08/01 00:01 [medline] PHST- 1980/08/01 00:00 [entrez] AID - 10.1111/j.1365-2044.1980.tb03919.x [doi] PST - ppublish SO - Anaesthesia. 1980 Aug;35(8):779-82. doi: 10.1111/j.1365-2044.1980.tb03919.x. PMID- 28538371 OWN - NLM STAT- MEDLINE DCOM- 20170626 LR - 20210109 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 96 IP - 21 DP - 2017 May TI - Comparison of the efficacy and safety of 2% lidocaine HCl with different epinephrine concentration for local anesthesia in participants undergoing surgical extraction of impacted mandibular third molars: A multicenter, randomized, double-blind, crossover, phase IV trial. PG - e6753 LID - 10.1097/MD.0000000000006753 [doi] LID - e6753 AB - BACKGROUND: The most commonly impacted tooth is the third molar. An impacted third molar can ultimately cause acute pain, infection, tumors, cysts, caries, periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for removing the third molar. This study aimed to evaluate the efficacy and safety of 2% lidocaine with 1:80,000 or 1:200,000 epinephrine for surgical extraction of bilateral impacted mandibular third molars. METHODS: Sixty-five healthy participants underwent surgical extraction of bilateral impacted mandibular third molars in 2 separate visits while under local anesthesia with 2% lidocaine with different epinephrine concentration (1:80,000 or 1:200,000) in a double-blind, randomized, crossover trial. Visual analog scale pain scores obtained immediately after surgical extraction were primarily evaluated for the 2 groups receiving different epinephrine concentrations. Visual analog scale pain scores were obtained 2, 4, and 6 hours after administering an anesthetic. Onset and duration of analgesia, onset of pain, intraoperative bleeding, operator's and participant's overall satisfaction, drug dosage, and hemodynamic parameters were evaluated for the 2 groups. RESULTS: There were no statistically significant differences between the 2 groups in any measurements except hemodynamic factors (P >.05). Changes in systolic blood pressure and heart rate following anesthetic administration were significantly greater in the group receiving 1:80,000 epinephrine than in that receiving 1:200,000 epinephrine (P ≤.01). CONCLUSION: The difference in epinephrine concentration between 1:80,000 and 1:200,000 in 2% lidocaine liquid does not affect the medical efficacy of the anesthetic. Furthermore, 2% lidocaine with 1:200,000 epinephrine has better safety with regard to hemodynamic parameters than 2% lidocaine with 1:80,000 epinephrine. Therefore, we suggest using 2% lidocaine with 1:200,000 epinephrine rather than 2% lidocaine with 1:80,000 epinephrine for surgical extraction of impacted mandibular third molars in hemodynamically unstable patients. FAU - Karm, Myong-Hwan AU - Karm MH AD - Department of Dental Anesthesiology Department of Dental Anesthesiology and Dental Research Institute, Seoul National University School of Dentistry Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul Department of Dental Anesthesiology, Dankook University College of Dentistry, Dankook University, Cheonan-si, Chungnam Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University and Institute of Translational Dental Sciences, Pusan National University Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University and Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Gyeongnam College of Dentistry, Wonkwang University, Iksan city, Jeonbuk Department of Oral and Maxillofacial Surgery, Dankook University College of Dentistry, Dankook University, Cheonan-si, Chungnam Department of Oral & Maxillofacial Surgery, Kyung Hee University Dental Hospital Kyung Hee University School of Dentistry, Seoul R&D Center, Huons Co. Ltd., College of Pharmacy, Hanyang University, Ansan-si, Kyeonggi-do, Republic of Korea. FAU - Park, Fiona Daye AU - Park FD FAU - Kang, Moonkyu AU - Kang M FAU - Kim, Hyun Jeong AU - Kim HJ FAU - Kang, Jeong Wan AU - Kang JW FAU - Kim, Seungoh AU - Kim S FAU - Kim, Yong-Deok AU - Kim YD FAU - Kim, Cheul-Hong AU - Kim CH FAU - Seo, Kwang-Suk AU - Seo KS FAU - Kwon, Kyung-Hwan AU - Kwon KH FAU - Kim, Chul-Hwan AU - Kim CH FAU - Lee, Jung-Woo AU - Lee JW FAU - Hong, Sung-Woon AU - Hong SW FAU - Lim, Mi Hyoung AU - Lim MH FAU - Nam, Seung Kwan AU - Nam SK FAU - Cho, Jae Min AU - Cho JM LA - eng PT - Clinical Trial, Phase IV PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) RN - YKH834O4BH (Epinephrine) SB - AIM SB - IM MH - Anesthesia, Local/adverse effects MH - Anesthetics, Local/*administration & dosage/adverse effects MH - Blood Loss, Surgical MH - Cross-Over Studies MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Epinephrine/*administration & dosage/adverse effects MH - Female MH - Hemodynamics/drug effects MH - Humans MH - Lidocaine/*administration & dosage/adverse effects MH - Male MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/drug therapy MH - Patient Satisfaction MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult PMC - PMC5457851 COIS- The authors have no conflicts of interest to disclose. EDAT- 2017/05/26 06:00 MHDA- 2017/06/27 06:00 CRDT- 2017/05/25 06:00 PHST- 2017/05/25 06:00 [entrez] PHST- 2017/05/26 06:00 [pubmed] PHST- 2017/06/27 06:00 [medline] AID - 00005792-201705260-00012 [pii] AID - MD-D-17-00274 [pii] AID - 10.1097/MD.0000000000006753 [doi] PST - ppublish SO - Medicine (Baltimore). 2017 May;96(21):e6753. doi: 10.1097/MD.0000000000006753. PMID- 8512909 OWN - NLM STAT- MEDLINE DCOM- 19930722 LR - 20190914 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 31 IP - 3 DP - 1993 Jun TI - Ketorolac and diclofenac for postoperative pain relief following oral surgery. PG - 158-60 AB - A double-blind clinical study was designed to compare the efficacy and safety of intramuscular and oral ketorolac, a new non-steroidal anti-inflammatory analgesic with that of diclofenac and placebo for patients undergoing removal of impacted mandibular third molar teeth. Results showed that both analgesic preparations were more effective than placebo (p = 0.0029) and that ketorolac provided a similar degree of pain relief to that of diclofenac. It is concluded that ketorolac is important new addition to the available intra-muscular NSAID preparations. FAU - Walton, G M AU - Walton GM AD - Department of Oral and Maxillofacial Surgery, Turner Dental School, Manchester. FAU - Rood, J P AU - Rood JP FAU - Snowdon, A T AU - Snowdon AT FAU - Rickwood, D AU - Rickwood D LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Placebos) RN - 144O8QL0L1 (Diclofenac) RN - 362O9ITL9D (Acetaminophen) RN - D8K2JPN18B (Tolmetin) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Acetaminophen/administration & dosage/therapeutic use MH - Administration, Oral MH - Adolescent MH - Adult MH - Aged MH - Analgesics/administration & dosage/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects/*therapeutic use MH - Diclofenac/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intramuscular MH - Ketorolac MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - Placebos MH - Tolmetin/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/surgery EDAT- 1993/06/01 00:00 MHDA- 1993/06/01 00:01 CRDT- 1993/06/01 00:00 PHST- 1993/06/01 00:00 [pubmed] PHST- 1993/06/01 00:01 [medline] PHST- 1993/06/01 00:00 [entrez] AID - 10.1016/0266-4356(93)90115-d [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1993 Jun;31(3):158-60. doi: 10.1016/0266-4356(93)90115-d. PMID- 26044602 OWN - NLM STAT- MEDLINE DCOM- 20160118 LR - 20161128 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 11 DP - 2015 Nov TI - Comparison of the Effects of Topical Ketamine and Tramadol on Postoperative Pain After Mandibular Molar Extraction. PG - 2103-7 LID - S0278-2391(15)00596-0 [pii] LID - 10.1016/j.joms.2015.05.012 [doi] AB - PURPOSE: This study compared the analgesic efficacy of postoperative tramadol versus ketamine for preventing pain after mandibular molar extraction. PATIENTS AND METHODS: Ninety patients who had undergone molar extraction were randomly divided into 3 groups: group T (tramadol 1 mg/kg), group K (ketamine 0.5 mg/kg), and group P (saline 2 mL). The treatment was applied to the extraction sockets using resorbable gelatin sponges. Pain after extraction was evaluated using a visual analog scale (VAS) 0.5, 1, 2, 4, 6, 12, 24, and 48 hours postoperatively. RESULTS: The VAS scores after extraction were statistically higher in group P than in either treatment group. Group K had the lowest pain intensity. CONCLUSION: This study shows that topical tramadol and ketamine are effective alternatives for decreasing pain after molar extractions. CI - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Gönül, Onur AU - Gönül O AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey. Electronic address: onurgonul96@gmail.com. FAU - Satilmiş, Tülin AU - Satilmiş T AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey. FAU - Ciftci, Alanur AU - Ciftci A AD - Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey. FAU - Sipahi, Aysegül AU - Sipahi A AD - Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey. FAU - Garip, Hasan AU - Garip H AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey. FAU - Göker, Kamil AU - Göker K AD - Professor, Head of Department, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20150521 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 39J1LGJ30J (Tramadol) RN - 690G0D6V8H (Ketamine) SB - AIM SB - D SB - IM CIN - J Oral Maxillofac Surg. 2016 May;74(5):873-4. PMID: 26850866 MH - Administration, Topical MH - Adult MH - Female MH - Humans MH - Ketamine/administration & dosage/*therapeutic use MH - Male MH - Mandible/*surgery MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*adverse effects MH - Tramadol/administration & dosage/*therapeutic use MH - Young Adult EDAT- 2015/06/06 06:00 MHDA- 2016/01/19 06:00 CRDT- 2015/06/06 06:00 PHST- 2015/02/25 00:00 [received] PHST- 2015/05/11 00:00 [revised] PHST- 2015/05/12 00:00 [accepted] PHST- 2015/06/06 06:00 [entrez] PHST- 2015/06/06 06:00 [pubmed] PHST- 2016/01/19 06:00 [medline] AID - S0278-2391(15)00596-0 [pii] AID - 10.1016/j.joms.2015.05.012 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Nov;73(11):2103-7. doi: 10.1016/j.joms.2015.05.012. Epub 2015 May 21. PMID- 25767068 OWN - NLM STAT- MEDLINE DCOM- 20160104 LR - 20150413 IS - 2212-4411 (Electronic) VI - 119 IP - 5 DP - 2015 May TI - Should aspirin be stopped before tooth extraction? A meta-analysis. PG - 522-30 LID - S2212-4403(15)00035-8 [pii] LID - 10.1016/j.oooo.2015.01.004 [doi] AB - OBJECTIVE: To carry out a standard meta-analysis to determine if aspirin should be stopped before tooth extraction. STUDY DESIGN: The PubMed, ScienceDirect, EBSCOhost, and Science Citation Index databases were searched for studies published up to September 30, 2014. Eligible studies were restricted to randomized controlled trials (RCTs) and controlled, nonrandomized trials. RESULTS: Three RCTs and seven controlled trials met the inclusion criteria (covering 1752 patients: 529 on aspirin therapy and 1223 not on aspirin therapy). The results showed that the risk of postoperative hemorrhage was significantly higher in patients on aspirin therapy (relative risk [RR] = 2.46; 95% confidence interval [CI]: 1.45-4.81) but that bleeding time (BT) was not significantly different between the two groups (standardized mean difference [SMD] = 0.63; 95% CI: -0.04 to 1.31). Sensitivity analyses showed that the results were unstable. CONCLUSIONS: We could reach a conclusion that BT is prolonged or hemorrhage is exacerbated by long-term use of aspirin. We recommend not stopping long-term aspirin use before tooth extraction but enhancing hemostasis methods, if necessary. CI - Copyright © 2015 Elsevier Inc. All rights reserved. FAU - Zhao, Bingjie AU - Zhao B AD - College of Stomatology, Shandong University, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China; Shandong Provincial Key Laboratory of Oral Biomedicine, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China. FAU - Wang, Peihuan AU - Wang P AD - Department of Stomatology, Jinan Military General Hospital, Jinan City, Shandong Province 250012, China. FAU - Dong, Yabing AU - Dong Y AD - College of Stomatology, Shandong University, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China; Shandong Provincial Key Laboratory of Oral Biomedicine, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China. FAU - Zhu, Yong AU - Zhu Y AD - College of Stomatology, Shandong University, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China; Shandong Provincial Key Laboratory of Oral Biomedicine, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China. FAU - Zhao, Huaqiang AU - Zhao H AD - College of Stomatology, Shandong University, Number 44, Wen Hua Xi Lu, Jinan City, Shandong Province 250012, China. Electronic address: Zhaohq@sdu.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20150203 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Aspirin/*administration & dosage MH - Humans MH - Oral Hemorrhage/*etiology/*prevention & control MH - *Tooth Extraction EDAT- 2015/03/15 06:00 MHDA- 2016/01/05 06:00 CRDT- 2015/03/14 06:00 PHST- 2014/10/24 00:00 [received] PHST- 2014/11/25 00:00 [revised] PHST- 2015/01/14 00:00 [accepted] PHST- 2015/03/14 06:00 [entrez] PHST- 2015/03/15 06:00 [pubmed] PHST- 2016/01/05 06:00 [medline] AID - S2212-4403(15)00035-8 [pii] AID - 10.1016/j.oooo.2015.01.004 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 May;119(5):522-30. doi: 10.1016/j.oooo.2015.01.004. Epub 2015 Feb 3. PMID- 19893562 OWN - NLM STAT- MEDLINE DCOM- 20100323 LR - 20151119 IS - 1476-5373 (Electronic) IS - 0007-0610 (Linking) VI - 207 IP - 12 DP - 2009 Dec 19 TI - ECG variations in patients pre- and post-local anaesthesia and analgesia. PG - E23 LID - 10.1038/sj.bdj.2009.978 [doi] AB - OBJECTIVES: To determine the incidence of ECG abnormalities in a healthy adults undergoing a surgical extraction of third molar teeth pre-and post-operatively and to study the effect of local anaesthetics, surgical stress and analgesics on cardiac rhythm. METHOD: One hundred and ninety-eight healthy adult patients taking part in a clinical trial of analgesics were randomly selected for this study. All patients required the removal of at least one impacted mandibular wisdom tooth under local anaesthetic. An ECG was taken at a screening visit and repeated post-operatively 30 minutes after analgesia was given. The effects of analgesia were also monitored to ascertain whether any changes were related to pain experience or the analgesic itself. RESULTS: ECG abnormalities were detected in 44 patients at the screening visit. Of these patients, 20 showed rsR complex patterns, seven showed non-specific ST elevation, six patients had an abnormal P wave axis, three patients presented with single atrial premature beats and three patients showed a short PR interval. Other minor abnormalities were occasionally seen. The results recorded were of minimal clinical significance and the numbers are in line with previous research. Post-operative abnormalities were seen in 60 patients. Nineteen patients showed rsR complex patterns, sinus arrhythmias were seen in 11 individuals, seven patients showed non-specific ST elevation and six patients had an abnormal P-wave axis. Other minor abnormalities were occasionally seen. CONCLUSION: Although the results were not statistically significant, some of the patients did show clinically relevant abnormalities which necessitated referral to a cardiologist. These included: marked ST elevation; marked ST depression and one case of Right Bundle Branch Block (RBBB). FAU - Hill, C M AU - Hill CM AD - Department of Oral Surgery, Dental Hospital, Heath Park, Cardiff, CF14 4XY. hillcm@cardiff.ac.uk FAU - Mostafa, P AU - Mostafa P FAU - Stuart, A G AU - Stuart AG FAU - Thomas, D W AU - Thomas DW FAU - Walker, R V AU - Walker RV LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20091106 PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - 0 (Analgesics) RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anesthetics, Local) RN - 0 (Placebos) RN - 046O35D44R (Prilocaine) RN - 55JG375S6M (Pregabalin) RN - 56-12-2 (gamma-Aminobutyric Acid) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Adult MH - Analgesics/*therapeutic use MH - Analgesics, Non-Narcotic/therapeutic use MH - *Anesthesia, Dental MH - Anesthetics, Local/*administration & dosage MH - Arrhythmia, Sinus/physiopathology MH - Atrial Premature Complexes/physiopathology MH - Bundle-Branch Block/physiopathology MH - *Electrocardiography/drug effects MH - Follow-Up Studies MH - Heart/drug effects/*physiology MH - Heart Rate/drug effects/physiology MH - Humans MH - Ibuprofen/therapeutic use MH - Mandible/surgery MH - Molar, Third/surgery MH - Myocardial Contraction/drug effects/physiology MH - Placebos MH - Pregabalin MH - Preoperative Care MH - Prilocaine/administration & dosage MH - Stress, Physiological/drug effects MH - Tooth Extraction MH - Tooth, Impacted/surgery MH - gamma-Aminobutyric Acid/analogs & derivatives/therapeutic use EDAT- 2009/11/07 06:00 MHDA- 2010/03/24 06:00 CRDT- 2009/11/07 06:00 PHST- 2009/02/05 00:00 [accepted] PHST- 2009/11/07 06:00 [entrez] PHST- 2009/11/07 06:00 [pubmed] PHST- 2010/03/24 06:00 [medline] AID - sj.bdj.2009.978 [pii] AID - 10.1038/sj.bdj.2009.978 [doi] PST - ppublish SO - Br Dent J. 2009 Dec 19;207(12):E23. doi: 10.1038/sj.bdj.2009.978. Epub 2009 Nov 6. PMID- 30212961 OWN - NLM STAT- MEDLINE DCOM- 20180925 LR - 20210112 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 97 IP - 37 DP - 2018 Sep TI - Efficacy of diode-emitting diode (LED) photobiomodulation in pain management, facial edema, trismus, and quality of life after extraction of retained lower third molars: A randomized, double-blind, placebo-controlled clinical trial. PG - e12264 LID - 10.1097/MD.0000000000012264 [doi] LID - e12264 AB - BACKGROUND: In dentistry, one of the most common surgical procedures is the removal of retained third molars. This surgery generates great morbidity to the participants for causing pain, edema, and trismus due to surgical trauma. The objective of the present study is to evaluate the efficacy of photobiomodulation with light emitting diode (LED) in the control of pain, facial edema, trismus, and quality of life resulting from the extraction of retained lower third molars. METHODS: A randomized, double-blind, placebo-controlled clinical trial involving 38 adult participants, who meet the criteria of eligibility and agree to participate in the study. Before the surgeries are performed, the facial and mouth opening measures of all the participants will be taken. Immediately after the surgeries, participants will be randomized into 2 groups. In the LED group, participants will receive LED applications (intra oral with 660 nm, 12J and extraoral with 850 nm, 108J) in the immediate postoperative, first and second days after the surgical procedure. In the control group, the participants will be attended in the same way as in the LED group, however, the person in charge of the application will simulate the irradiation. Pain (EVA and NRS-101), postoperative edema, trismus, temperature, dysphagia, and hematoma will be evaluated after 1, 2, 5, and 7 days. The oral health impact profile (OHIP-14 Questionnaire) and anxiety analysis (Beck anxiety inventory -BAI) questionnaires will be applied preoperatively and 7 days after treatment. The appropriate statistical tests will be applied for each specific analysis in a significance level of 5%. DISCUSSION: Although the use of low-power laser in the postoperative has shown good results in the control of postoperative sequelae, this is the first study on the efficacy of the use of LED in this situation. FAU - Tenis, Carlos Alberto AU - Tenis CA AD - Universidade Nove de Julho, Liberdade , São Paulo SP Universidade Federal do Rio Grande do Sul, Universidade Estadual de Campinas, Paulo Gama Avenue, Farroupilha , Porto Alegre, RS Universidade Nove de Julho, Liberdade, São Paulo, SP Pontifícia Universidade Católica do Rio Grande do Sul, Ipiranga Avenue, Paternon Faculty of Dentistry of Universidade Federal do Rio Grande do Sul, Paulo Gama Avenue, Farroupilha, Porto Alegre, RS Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Liberdade Universidade Nove de Julho, Liberdade, São Paulo, SP, Brazil. FAU - Martins, Manoela Domingues AU - Martins MD FAU - Gonçalves, Marcela Leticia Leal AU - Gonçalves MLL FAU - Silva, Daniela de Fátima Teixeira da AU - Silva DFTD FAU - Cunha Filho, João Júlio da AU - Cunha Filho JJD FAU - Martins, Marco Antonio Trevizani AU - Martins MAT FAU - Mesquita-Ferrari, Raquel Agnelli AU - Mesquita-Ferrari RA FAU - Bussadori, Sandra Kalil AU - Bussadori SK FAU - Fernandes, Kristianne Porta Santos AU - Fernandes KPS LA - eng PT - Journal Article PT - Randomized Controlled Trial TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - AIM SB - IM EIN - Medicine (Baltimore). 2018 Oct;97(41):e12882. PMID: 30313126 MH - Double-Blind Method MH - Edema/prevention & control MH - Face MH - Humans MH - Lasers, Semiconductor MH - Low-Level Light Therapy/*methods MH - *Molar, Third MH - Pain Management/methods MH - Quality of Life MH - Research Design MH - Tooth Extraction/*methods MH - Trismus/prevention & control PMC - PMC6156019 COIS- The authors have no funding and no conflicts of interest to disclose. EDAT- 2018/09/15 06:00 MHDA- 2018/09/27 06:00 CRDT- 2018/09/15 06:00 PHST- 2018/09/15 06:00 [entrez] PHST- 2018/09/15 06:00 [pubmed] PHST- 2018/09/27 06:00 [medline] AID - 00005792-201809140-00038 [pii] AID - MD-D-18-05633 [pii] AID - 10.1097/MD.0000000000012264 [doi] PST - ppublish SO - Medicine (Baltimore). 2018 Sep;97(37):e12264. doi: 10.1097/MD.0000000000012264. PMID- 30883942 OWN - NLM STAT- MEDLINE DCOM- 20191022 LR - 20191022 IS - 1600-0501 (Electronic) IS - 0905-7161 (Linking) VI - 30 IP - 5 DP - 2019 May TI - A randomized controlled clinical trial evaluating efficacy and adverse events of different types of recombinant human bone morphogenetic protein-2 delivery systems for alveolar ridge preservation. PG - 396-409 LID - 10.1111/clr.13423 [doi] AB - OBJECTIVES: This 12-week clinical trial evaluated efficacy and adverse events for two recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery systems in alveolar ridge preservation. MATERIALS AND METHODS: Sixty-four patients had a single tooth that required replacement with an implant, surrounded by > 50% alveolar bone height. Two cohorts (n = 32 patients each) were randomized to receive a rhBMP-2-soaked absorbable collagen sponge (test group), or β-tricalcium phosphate and hydroxyapatite particles (control group) immersed in rhBMP-2, at the implant site. Bone height and width changes at 25%, 50%, and 75% of extraction socket level (ESL) were compared. Adverse events were assessed in the same period. In addition to the randomized controlled clinical trial, histological analysis of 21 patients (test group [n = 12], control group [n = 9]) was conducted, 4 months after alveolar ridge preservation. A non-inferiority test was used to analyze changes in alveolar bone height between groups (p = 0.05). A Wilcoxon rank-sum test was used to analyze changes in alveolar bone width and histomorphometric results between groups (p = 0.05). RESULTS: All patients showed good healing without severe adverse events. The lower limit of the one-sided 97.5% confidence interval in the difference between the two groups was 0.0033 (non-inferiority margin: -0.185); thus, the test group showed non-inferiority to the control group. Wilcoxon rank-sum test analysis did not show statistically significant differences between groups with regard to changes in alveolar bone width and histomorphometric analysis. CONCLUSIONS: The delivery systems showed similar efficacy for alveolar ridge preservation without severe adverse events. CI - © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Jo, Deuk-Won AU - Jo DW AD - Department of Prosthodontics, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea. FAU - Cho, Young-Dan AU - Cho YD AD - Department of Periodontology & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. FAU - Seol, Yang-Jo AU - Seol YJ AUID- ORCID: 0000-0002-2076-5452 AD - Department of Periodontology & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. FAU - Lee, Yong-Moo AU - Lee YM AUID- ORCID: 0000-0002-5619-3847 AD - Department of Periodontology & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. FAU - Lee, Hyo-Jung AU - Lee HJ AD - Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea. FAU - Kim, Young-Kyun AU - Kim YK AUID- ORCID: 0000-0002-7268-3870 AD - Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea. AD - Department of Dentistry & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. LA - eng GR - HI15C0871/Korea Health Industry Development Institute/Republic of Korea GR - 02-2016-030/Seoul National University Bundang Hospital/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20190411 PL - Denmark TA - Clin Oral Implants Res JT - Clinical oral implants research JID - 9105713 RN - 0 (Bone Morphogenetic Protein 2) RN - 0 (Recombinant Proteins) RN - 0 (Transforming Growth Factor beta) RN - 0 (recombinant human bone morphogenetic protein-2) SB - D MH - *Alveolar Bone Loss MH - Alveolar Process MH - *Alveolar Ridge Augmentation MH - Bone Morphogenetic Protein 2 MH - Humans MH - Recombinant Proteins MH - Tooth Extraction MH - Tooth Socket MH - Transforming Growth Factor beta OTO - NOTNLM OT - Randomized controlled clinical trial OT - alveolar ridge preservation OT - delivery system OT - recombinant human bone morphogenetic protein-2 EDAT- 2019/03/19 06:00 MHDA- 2019/10/23 06:00 CRDT- 2019/03/19 06:00 PHST- 2018/02/23 00:00 [received] PHST- 2019/01/29 00:00 [revised] PHST- 2019/01/29 00:00 [accepted] PHST- 2019/03/19 06:00 [pubmed] PHST- 2019/10/23 06:00 [medline] PHST- 2019/03/19 06:00 [entrez] AID - 10.1111/clr.13423 [doi] PST - ppublish SO - Clin Oral Implants Res. 2019 May;30(5):396-409. doi: 10.1111/clr.13423. Epub 2019 Apr 11. PMID- 2507667 OWN - NLM STAT- MEDLINE DCOM- 19891108 LR - 20190918 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 18 IP - 4 DP - 1989 Aug TI - A comparison of two sedative premedications for minor oral surgery under local anaesthesia. PG - 202-5 AB - Two commonly used drug combinations were studied as premedications before surgical 3rd molar removal under local anaesthesia. The study was randomized, crossover and double-blind in 12 patients. Our routine premedication for lengthy operations, consisting of diazepam 10 mg p.o. plus i.m. scopolamine 0.006 mg/kg and morphine 0.2 mg/kg, was compared with a combination of diazepam 10 mg p.o. plus metoprolol 50 mg p.o. The latter combination was expected to cause fewer central nervous system side effects and be more suitable for out-patient surgery. Drug levels in blood, physiological and biochemical indicators of operation-related stress, CNS side effects, and the patients' subjective preferences were monitored. Both combinations were equally accepted by the patients, but the diazepam/scopolamine/morphine combination caused clearly more side effects after discharge than diazepam/metoprolol. The operation-related haemodynamic changes and plasma catecholamine responses were similar after both premedications. FAU - Salonen, M AU - Salonen M AD - Department of Anaesthesiology, University of Turku, Finland. FAU - Forssell, H AU - Forssell H FAU - Lehmijoki, O AU - Lehmijoki O FAU - Kaila, T AU - Kaila T FAU - Scheinin, M AU - Scheinin M LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 RN - 76I7G6D29C (Morphine) RN - DL48G20X8X (Scopolamine) RN - GEB06NHM23 (Metoprolol) RN - Q3JTX2Q7TU (Diazepam) SB - D SB - IM MH - Adult MH - *Anesthesia, Dental MH - *Anesthesia, Local MH - Blood Pressure/drug effects MH - Diazepam/administration & dosage/blood MH - Double-Blind Method MH - Drug Therapy, Combination MH - Female MH - Heart Rate/drug effects MH - Humans MH - Male MH - Metoprolol/administration & dosage/blood/*pharmacology MH - Molar, Third/surgery MH - Morphine/administration & dosage MH - *Preanesthetic Medication MH - Random Allocation MH - Scopolamine/administration & dosage/blood/*pharmacology MH - *Tooth Extraction EDAT- 1989/08/01 00:00 MHDA- 1989/08/01 00:01 CRDT- 1989/08/01 00:00 PHST- 1989/08/01 00:00 [pubmed] PHST- 1989/08/01 00:01 [medline] PHST- 1989/08/01 00:00 [entrez] AID - 10.1016/s0901-5027(89)80052-9 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 1989 Aug;18(4):202-5. doi: 10.1016/s0901-5027(89)80052-9. PMID- 12189364 OWN - NLM STAT- MEDLINE DCOM- 20020916 LR - 20131121 IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 72 IP - 2 DP - 2002 Aug TI - Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: replicate clinical trials in a tissue injury model. PG - 175-83 AB - BACKGROUND: Nonsteroidal anti-inflammatory drug (NSAID) analgesia is generally attributed to peripheral suppression of cyclooxygenase (COX) enzymes, leading to decreased products of the arachidonic acid cascade. This study evaluated the in vivo relationship between levels of prostanoids at the site of tissue injury and analgesia after systemic or local NSAID administration in a clinical model of tissue injury. METHODS: Subjects in two replicate clinical trials had one or two mandibular third molars removed and a microdialysis probe implanted at the surgical site for measurement of immunoreactive prostaglandin E(2) (PGE(2)) or immunoreactive thromboxane B(2) (TxB(2)) and pain measured concurrently. In the first study, ketorolac tromethamine (INN, ketorolac) was administered at pain onset in a 30-mg intramuscular dose, a 1-mg intramuscular dose, or a 1-mg submucosal dose at the extraction site in comparison with placebo. In the second study, subjects received either ketorolac tromethamine 30 mg by the intravenous route or placebo at pain onset. RESULTS: PGE(2) was detectable in the first postoperative sample, decreased over the next hour, and then increased significantly coincident with the onset of postoperative pain. Administration of 30 mg ketorolac tromethamine produced parallel decreases in pain, PGE(2) levels, and TxB(2) levels at the surgical site. Administration of 1 mg ketorolac tromethamine intramuscularly or directly at the surgical site was analgesic but without measurable effects on PGE(2) levels. CONCLUSION: The temporal profile of PGE(2) and TxB(2) in the immediate postoperative period is consistent with constitutive COX-1 initially, followed by an increase in PGE(2) resulting from expression of COX-2. The temporal association between NSAID analgesia and decreased prostanoids at the site of injury is consistent with a dual COX-1/COX-2 peripheral site of action. The analgesic effects of 1 mg ketorolac tromethamine without a reduction in PGE(2) at the site of injury suggests an additional central site for NSAID analgesia. FAU - Gordon, Sharon M AU - Gordon SM AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg. 30, Room 106, 30 Convent Drive, Bethesda, MD 20892-4310, USA. sgordon@dir.nidcr.nih.gov FAU - Brahim, Jaime S AU - Brahim JS FAU - Rowan, Janet AU - Rowan J FAU - Kent, Allison AU - Kent A FAU - Dionne, Raymond A AU - Dionne RA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase Inhibitors) RN - 0 (Prostaglandins) RN - 4EVE5946BQ (Ketorolac Tromethamine) RN - 54397-85-2 (Thromboxane B2) RN - K7Q1JQR04M (Dinoprostone) SB - AIM SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology MH - Cyclooxygenase Inhibitors/administration & dosage/*pharmacology MH - Dinoprostone/metabolism MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intramuscular MH - Injections, Intravenous MH - Ketorolac Tromethamine/administration & dosage/*pharmacology MH - Male MH - Mandible/*metabolism/surgery MH - Microdialysis MH - Molar, Third/*surgery MH - Prostaglandins/*metabolism MH - Thromboxane B2/metabolism MH - Tooth Extraction/*adverse effects EDAT- 2002/08/22 10:00 MHDA- 2002/09/17 10:01 CRDT- 2002/08/22 10:00 PHST- 2002/08/22 10:00 [pubmed] PHST- 2002/09/17 10:01 [medline] PHST- 2002/08/22 10:00 [entrez] AID - S0009923602000383 [pii] AID - 10.1067/mcp.2002.126501 [doi] PST - ppublish SO - Clin Pharmacol Ther. 2002 Aug;72(2):175-83. doi: 10.1067/mcp.2002.126501. PMID- 20708320 OWN - NLM STAT- MEDLINE DCOM- 20110602 LR - 20110328 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 69 IP - 4 DP - 2011 Apr TI - Musical intervention reduces patients' anxiety in surgical extraction of an impacted mandibular third molar. PG - 1036-45 LID - 10.1016/j.joms.2010.02.045 [doi] AB - PURPOSE: Patients undergoing impacted mandibular third molar (IMTM) extraction often have severe perioperative anxiety, which may lead to increased perceptions of pain and vital sign instability throughout surgery. Intraoperational musical interventions have been used during operations to decrease patient anxiety levels. We investigated the anxiolytic effects of musical intervention during surgical extraction of an IMTM. We tested the hypothesis that musical intervention would have positive effects on patients' vital signs, anxiety levels, and perceptions of pain. PATIENTS AND METHODS: We recruited 219 patients with IMTM surgery to participate in this study. Participants were randomly assigned to a music-treated group (106 subjects) or a control group (113 subjects). In a preoperative meeting, patient demographic data were collected, and the patients' favorite songs were selected. For the music-treated group, their selected music was played from the time of arrival to the operating room until the end of the operation. Perioperative anxiety and perceptions of pain were assessed using the Dental Anxiety Scale and the Visual Analog Scale, respectively. Patients' vital signs (blood pressure, heart rate, and respiratory rate) were monitored throughout the surgery. One-way analysis of covariance using perioperative anxiety as a covariant was performed to compare intraoperative anxiety levels and perioperative perceptions of pain between the 2 groups. Repeated measures analysis of variance was used to compare changes in vital signs across surgical stages between the 2 groups. RESULTS: Vital signs changed significantly throughout surgery according to the stage of the procedure. For both groups, vital signs increased from baseline and reached peak values at the time of the initial incision and then decreased quickly and plateaued within normal limits. There were no significant differences between groups in blood pressure; however, the music-treated group showed a significantly smaller change in heart rate than the control group. The music-treated group reported significantly less intraoperative anxiety than the nonmusic-treated control group when controlling for preoperative anxiety levels (F = 4.226, P < .05). CONCLUSION: These results support the hypothesis that the use of patient-chosen music during surgical extraction of an IMTM significantly lowers patient intraoperative anxiety levels. CI - Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Kim, Yu-Kyoung AU - Kim YK AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Chong-No gu, Seoul, Korea. FAU - Kim, Soung-Min AU - Kim SM FAU - Myoung, Hoon AU - Myoung H LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20100812 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Anesthetics, Local) SB - AIM SB - D SB - IM MH - Adult MH - Anesthetics, Local/administration & dosage MH - Blood Pressure/physiology MH - Dental Anxiety/*prevention & control MH - Female MH - Heart Rate/physiology MH - Hemostatic Techniques MH - Humans MH - Intraoperative Complications/prevention & control MH - Male MH - Mandibular Nerve MH - Molar, Third/*surgery MH - Music/*psychology MH - Nerve Block MH - Osteotomy MH - Pain Measurement MH - Pain Threshold/psychology MH - Pain, Postoperative/classification/prevention & control MH - Respiration MH - Suture Techniques MH - Tooth Extraction/*psychology MH - Tooth, Impacted/classification/*surgery MH - Vital Signs/physiology EDAT- 2010/08/17 06:00 MHDA- 2011/06/03 06:00 CRDT- 2010/08/17 06:00 PHST- 2009/10/01 00:00 [received] PHST- 2009/11/13 00:00 [revised] PHST- 2010/02/16 00:00 [accepted] PHST- 2010/08/17 06:00 [entrez] PHST- 2010/08/17 06:00 [pubmed] PHST- 2011/06/03 06:00 [medline] AID - S0278-2391(10)00277-6 [pii] AID - 10.1016/j.joms.2010.02.045 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2011 Apr;69(4):1036-45. doi: 10.1016/j.joms.2010.02.045. Epub 2010 Aug 12. PMID- 14693612 OWN - NLM STAT- MEDLINE DCOM- 20040120 LR - 20190704 IS - 0003-2999 (Print) IS - 0003-2999 (Linking) VI - 98 IP - 1 DP - 2004 Jan TI - Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: comparison with morphine after dental surgery. PG - 159-65, table of contents AB - We conducted this double-blinded, randomized study to assess the analgesic effect of repeated administrations of paracetamol, administered as propacetamol, an injectable prodrug formulation of paracetamol, and to compare this with the analgesic effects of morphine. Patients experiencing moderate to severe pain after elective surgical removal of bone-impacted third-molar teeth under general anesthesia were randomly assigned to receive IV propacetamol 2 g (n = 31), IM morphine 10 mg (n = 30), or placebo (n = 34). Five hours later, the treatments were readministered at half of the previous dosages. Standard measures of analgesia were collected repeatedly for 10 h. Propacetamol and morphine were significantly more effective than placebo in all primary measures of analgesia over 5 h after the first administration and globally over 10 h (first and second administrations). After the first dose, 21 of the 34 patients in the placebo group required rescue medication, compared with 6 of the 31 in the propacetamol group (P < 0.0009) and 4 of the 30 in the morphine group (P < 0.0001). No statistically or clinically significant differences were found between propacetamol and morphine for any sum or peak measures of analgesia. No serious adverse events were reported; adverse events were significantly less frequent in the propacetamol group than in the morphine group (P < 0.027). Propacetamol administered IV in repeated doses (2 g followed by 1 g) has a significant analgesic effect that is indistinguishable from that of morphine administered IM (10 mg followed by 5 mg) after dental surgery, with better tolerability. IMPLICATIONS: After moderately painful surgical procedures, IV paracetamol, administered as propacetamol, may be an asset in the control of acute postoperative pain. FAU - Van Aken, Hugo AU - Van Aken H AD - Department of Anesthesiology and Intensive Care Medicine, University Hospital, University of Münster, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany. hva@anit.uni-muenster.de FAU - Thys, L AU - Thys L FAU - Veekman, Luc AU - Veekman L FAU - Buerkle, Hartmut AU - Buerkle H LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Anesth Analg JT - Anesthesia and analgesia JID - 1310650 RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - 5CHW4JMR82 (propacetamol) RN - 76I7G6D29C (Morphine) SB - AIM SB - IM MH - Acetaminophen/administration & dosage/*analogs & derivatives/*therapeutic use MH - Adolescent MH - Adult MH - Aged MH - Analgesics, Opioid/administration & dosage/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use MH - Blood Pressure/drug effects MH - Double-Blind Method MH - Female MH - Heart Rate/drug effects MH - Humans MH - Injections, Intramuscular MH - Injections, Intravenous MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Morphine/administration & dosage/*therapeutic use MH - Pain Measurement/drug effects MH - Pain, Postoperative/*drug therapy MH - Respiratory Mechanics/drug effects MH - *Tooth Extraction EDAT- 2003/12/25 05:00 MHDA- 2004/01/21 05:00 CRDT- 2003/12/25 05:00 PHST- 2003/12/25 05:00 [pubmed] PHST- 2004/01/21 05:00 [medline] PHST- 2003/12/25 05:00 [entrez] AID - 10.1213/01.ane.0000093312.72011.59 [doi] PST - ppublish SO - Anesth Analg. 2004 Jan;98(1):159-65, table of contents. doi: 10.1213/01.ane.0000093312.72011.59. PMID- 11433853 OWN - NLM STAT- MEDLINE DCOM- 20010823 LR - 20190709 IS - 0002-8177 (Print) IS - 0002-8177 (Linking) VI - 132 IP - 6 DP - 2001 Jun TI - Comparing efficacy and safety of four intravenous sedation regimens in dental outpatients. PG - 740-51 AB - BACKGROUND: Management of patients' fear and anxiety during dental treatment is a primary concern of dental practitioners. Pharmacological strategies used in outpatient dental settings must be both safe and effective. Regimens of intravenously administered sedative drugs were evaluated in a collaborative, multicenter study of outpatients undergoing removal of impacted third molars. METHODS: A total of 997 patients randomly received one of five treatments: placebo; midazolam administered to a clinical endpoint of conscious sedation (mean dose, 8.6 milligrams); midazolam plus additional midazolam as needed during the procedure (mean total dose, 12.2 mg); fentanyl (1.4 micrograms/kilogram) plus midazolam to achieve the same endpoint of conscious sedation (mean dose, 5.7 mg); or fentanyl (1.4 (micrograms/kg), midazolam (mean dose, 5.8 mg) and methohexital as needed during the procedure (mean dose, 61.0 mg). RESULTS: Each drug regimen reduced anxiety during surgery in comparison with placebo, with the combination of midazolam, fentanyl and methohexital resulting in significantly less anxiety in comparison with the other treatment groups. Pain reports by patients during surgery also were reduced significantly by the combination of fentanyl, midazolam and methohexital. Patients' global evaluations of the efficacy of sedation ranked midazolam with supplemental midazolam and the combination of fentanyl, midazolam and methohexital as significantly more efficacious than the other two drug regiments. The authors noted transient respiratory depression in patients in the two opioid-treated groups, but no other physiological changes were detected. CONCLUSIONS: These data provide evidence that the drugs and doses evaluated resulted in therapeutic benefit to dental outpatients, with minimal incidence of potentially serious adverse effects. CLINICAL IMPLICATIONS: The results of this large-scale study provide assurance to both the public and the dental profession of the safety of parenteral sedation with these drugs and combinations of these drugs when titrated slowly in the recommended doses by appropriately trained dentists. FAU - Dionne, R A AU - Dionne RA AD - Pain and Neurosensory Mechanisms Branch, National Institutes of Health, Building 10, Room 1N-117, 10 Center Drive, Bethesda, Md. 20892, USA. rdionne@dir.nider.nih.gov FAU - Yagiela, J A AU - Yagiela JA FAU - Moore, P A AU - Moore PA FAU - Gonty, A AU - Gonty A FAU - Zuniga, J AU - Zuniga J FAU - Beirne, O R AU - Beirne OR LA - eng GR - DE-72565-69/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - J Am Dent Assoc JT - Journal of the American Dental Association (1939) JID - 7503060 RN - 0 (Anesthetics, Intravenous) RN - 0 (Hypnotics and Sedatives) RN - 0 (Placebos) RN - E5B8ND5IPE (Methohexital) RN - R60L0SM5BC (Midazolam) RN - UF599785JZ (Fentanyl) SB - D SB - IM MH - *Ambulatory Surgical Procedures MH - Analysis of Variance MH - Anesthesia, Dental/*methods MH - Anesthetics, Intravenous/administration & dosage MH - Chi-Square Distribution MH - Conscious Sedation MH - Dental Anxiety/prevention & control MH - Female MH - Fentanyl/administration & dosage MH - Follow-Up Studies MH - Humans MH - Hypnotics and Sedatives/*administration & dosage MH - Male MH - Methohexital/administration & dosage MH - Midazolam/administration & dosage MH - Molar, Third/surgery MH - Pain, Postoperative/prevention & control MH - Patient Satisfaction MH - Placebos MH - Preanesthetic Medication/*methods MH - Respiration/drug effects MH - Safety MH - Statistics, Nonparametric MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Treatment Outcome EDAT- 2001/07/04 10:00 MHDA- 2001/08/24 10:01 CRDT- 2001/07/04 10:00 PHST- 2001/07/04 10:00 [pubmed] PHST- 2001/08/24 10:01 [medline] PHST- 2001/07/04 10:00 [entrez] AID - S0002-8177(14)61739-6 [pii] AID - 10.14219/jada.archive.2001.0271 [doi] PST - ppublish SO - J Am Dent Assoc. 2001 Jun;132(6):740-51. doi: 10.14219/jada.archive.2001.0271. PMID- 3731680 OWN - NLM STAT- MEDLINE DCOM- 19860917 LR - 20190510 IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 40 IP - 2 DP - 1986 Aug TI - Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery. PG - 165-71 AB - Forty-eight patients received either naloxone (10 mg), fentanyl (0.1 mg), diazepam (0.3 mg/kg), or saline solution placebo, and then underwent surgical removal of impacted third molars under local anesthesia. Placebo resulted in significantly elevated levels of immunoreactive beta-endorphin (i beta-END), norepinephrine, and anxiety during surgery. Patients receiving naloxone had significantly greater intraoperative i beta-END and pain as compared with those receiving placebo. The naloxone effect on intraoperative pain was a result of a difference in perceived unpleasantness. Both the fentanyl and diazepam groups had significantly lower intraoperative i beta-END and anxiety levels as compared with the placebo group. Norepinephrine levels increased significantly in response to surgical stress in all groups except the diazepam group. Postoperative circulating levels of i beta-END and norepinephrine and pain increased significantly from the 1 to 3-hour postoperative period for all groups, with the exception of stable norepinephrine levels observed in patients receiving diazepam. Results indicate that opiate antagonists stimulate and agonists suppress the release of i beta-END, possibly by affecting the patient's perceived level of pain and anxiety. In addition, the association of intraoperative hyperalgesia with naloxone predosing suggests that endogenous opioid peptides inhibit the perception of intraoperative pain even in the presence of concurrent local anesthesia. FAU - Hargreaves, K M AU - Hargreaves KM FAU - Dionne, R A AU - Dionne RA FAU - Mueller, G P AU - Mueller GP FAU - Goldstein, D S AU - Goldstein DS FAU - Dubner, R AU - Dubner R LA - eng GR - R03 DE 06392/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Endorphins) RN - 36B82AMQ7N (Naloxone) RN - Q3JTX2Q7TU (Diazepam) RN - UF599785JZ (Fentanyl) SB - AIM SB - IM MH - Diazepam/*therapeutic use MH - Double-Blind Method MH - Drug Evaluation MH - Endorphins/*blood MH - Fentanyl/*therapeutic use MH - Humans MH - Intraoperative Period MH - Molar, Third MH - Naloxone/*therapeutic use MH - Pain/*prevention & control MH - Premedication MH - Tooth, Impacted/*surgery EDAT- 1986/08/01 00:00 MHDA- 1986/08/01 00:01 CRDT- 1986/08/01 00:00 PHST- 1986/08/01 00:00 [pubmed] PHST- 1986/08/01 00:01 [medline] PHST- 1986/08/01 00:00 [entrez] AID - 0009-9236(86)90047-0 [pii] AID - 10.1038/clpt.1986.159 [doi] PST - ppublish SO - Clin Pharmacol Ther. 1986 Aug;40(2):165-71. doi: 10.1038/clpt.1986.159. PMID- 16416663 OWN - NLM STAT- MEDLINE DCOM- 20060131 LR - 20131121 IS - 0083-8969 (Print) IS - 0083-8969 (Linking) VI - 48 DP - 2005 TI - Analgesic efficacy of tramadol by route of administration in a clinical model of pain. PG - 61-4 AB - The objective of this study was to evaluate the analgesic efficacy produced by tramadol given by two different routes of administration in patients experiencing pain after removal of an impacted mandibular third molar under local anesthesia. A double-blind, randomized, placebo-controlled clinical trial was conducted. Patients were assigned into four groups of treatment, twelve subjects per group: Group A, tramadol 50 mg IM one hr before surgery; group B, tramadol 50 mg into the surgical site; group C, tramadol by both routes of administration, 50 mg IM one hr before surgery plus 50 mg into the surgical site; and group D, control. We evaluated intensity of pain and analgesic consumption as was requested. Demographic characteristics and variables describing the difficulty of the surgical procedure were similar between groups. The duration of the anesthetic effect was significantly longer in the groups where tramadol was injected into the surgical site (215 and 252 min). Administration of systemic and local tramadol (50 mg) suppressed the pain intensity values in comparison to the control group (p < 0.05). Also, tramadol in both routes of administration suppressed the pain intensity values in comparison to all groups (p < 0.05). A significant reduction in the consumption of ketorolac was seen in all treatments as compared to the control group. However, only in the route combination group was a significant reduction in the requirement of acetaminophen observed. Nine patients requiring additional medication were treated with ketorolac 30 mg injected intramuscularly; 2 in the systemic group, 2 in the local group, 4 in the control group and only 1 in the combination group. Adverse events were minimal and similar in all groups. FAU - Pozos-Guillén, Amaury de Jesús AU - Pozos-Guillén Ade J AD - Facultad de Estomatologia, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava #2, Zona Universitaria C.P. apozos@uaslp.mx FAU - Martínez-Rider, Ricardo AU - Martínez-Rider R FAU - Aguirre-Bañuelos, Patricia AU - Aguirre-Bañuelos P FAU - Arellano-Guerrero, Abraham AU - Arellano-Guerrero A FAU - Hoyo-Vadillo, Carlos AU - Hoyo-Vadillo C FAU - Pérez-Urizar, José AU - Pérez-Urizar J LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Proc West Pharmacol Soc JT - Proceedings of the Western Pharmacology Society JID - 7505899 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - 39J1LGJ30J (Tramadol) RN - YZI5105V0L (Ketorolac) SB - IM MH - Acetaminophen/administration & dosage/therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/therapeutic use MH - Analgesics, Opioid/*administration & dosage/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Injections MH - Injections, Intramuscular MH - Ketorolac/administration & dosage/therapeutic use MH - Male MH - Middle Aged MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction MH - Tooth, Impacted/surgery MH - Tramadol/*administration & dosage/*therapeutic use EDAT- 2006/01/19 09:00 MHDA- 2006/02/01 09:00 CRDT- 2006/01/19 09:00 PHST- 2006/01/19 09:00 [pubmed] PHST- 2006/02/01 09:00 [medline] PHST- 2006/01/19 09:00 [entrez] PST - ppublish SO - Proc West Pharmacol Soc. 2005;48:61-4. PMID- 9690243 OWN - NLM STAT- MEDLINE DCOM- 19981020 LR - 20190909 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 86 IP - 1 DP - 1998 Jul TI - A dose-ranging study of bromfenac sodium in oral surgery pain. PG - 36-41 AB - OBJECTIVE: The purpose of this study was to evaluate the analgesic efficacy and safety of five graded doses of bromfenac sodium in patients experiencing moderate to severe pain after the surgical removal of impacted third molar teeth. STUDY DESIGN: The study employed a randomized, double-blind, single-dose, 8-hour, inpatient evaluation period. The treatment groups included placebo (n = 21) and bromfenac (n = 102) at dosage strengths of 5 mg (n = 21), 25 mg (n = 20), 50 mg (n = 20), 100 mg (n = 20), and 200 mg (n = 21). Patients ingested a dose of study medication when their postsurgical pain reached a moderate or severe intensity. Pain intensity and pain relief were rated at 15, 30, 60, 90, and 120 minutes and then hourly for the remaining 6 hours. Efficacy and safety variables were analyzed by means of analysis of variance and chi-squared tests where appropriate. RESULTS: At all doses, bromfenac exhibited statistical superiority (p < 0.05) to placebo, with all but the 5-mg dose being significantly more efficacious for every summary analgesic measure (3- and 8-hour sum pain intensity difference and sum pain analog intensity difference, total pain relief, peak effects, sum of pain half gone, and global evaluation). Peak analgesic effects did not increase beyond those provided by the 25-mg dose of bromfenac, although both the 100- and 200-mg bromfenac doses provided a more rapid onset and a longer duration of analgesia than either the 25- or 50-mg dosage strengths. The most common side effects reported were headache, nausea, dizziness, and drowsiness; the incidence in the bromfenac group was no different from that in the placebo group. CONCLUSIONS: Bromfenac is a safe and efficacious analgesic, with a threshold dose of 5 mg and a positive dose-response up to 25 mg for peak effects and 100 mg for total analgesic activity. FAU - Hersh, E V AU - Hersh EV AD - University of Pennsylvania School of Dental Medicine, Philadelphia, USA. FAU - Cooper, S A AU - Cooper SA FAU - Levin, L M AU - Levin LM FAU - Betts, N J AU - Betts NJ FAU - Wedell, D AU - Wedell D FAU - Lamp, C AU - Lamp C FAU - Wajdula, J AU - Wajdula J LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 RN - 0 (Analgesics) RN - 0 (Benzophenones) RN - 0 (Bromobenzenes) RN - 0 (Placebos) RN - 864P0921DW (bromfenac) SB - D SB - IM MH - Adult MH - Analgesics/administration & dosage/adverse effects/*therapeutic use MH - Analysis of Variance MH - Benzophenones/administration & dosage/adverse effects/*therapeutic use MH - Bromobenzenes/administration & dosage/adverse effects/*therapeutic use MH - Chi-Square Distribution MH - Dizziness/chemically induced MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Evaluation Studies as Topic MH - Female MH - Follow-Up Studies MH - Headache/chemically induced MH - Humans MH - Incidence MH - Male MH - Molar, Third/surgery MH - Nausea/chemically induced MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Placebos MH - Safety MH - Sleep Stages/drug effects MH - Time Factors MH - *Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1998/08/05 00:00 MHDA- 1998/08/05 00:01 CRDT- 1998/08/05 00:00 PHST- 1998/08/05 00:00 [pubmed] PHST- 1998/08/05 00:01 [medline] PHST- 1998/08/05 00:00 [entrez] AID - S1079-2104(98)90147-0 [pii] AID - 10.1016/s1079-2104(98)90147-0 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Jul;86(1):36-41. doi: 10.1016/s1079-2104(98)90147-0. PMID- 11572225 OWN - NLM STAT- MEDLINE DCOM- 20011018 LR - 20140728 IS - 1044-5471 (Print) IS - 1044-5471 (Linking) VI - 18 IP - 6 DP - 2000 Dec TI - Low-level laser therapy after molar extraction. PG - 309-15 AB - OBJECTIVE: The aim of the study was to evaluate effect of the different frequencies of low-level laser radiation (diode 670 nm and Helium-Neon 632.8 nm) on the healing process after human molar extractions. Frequencies of 5 Hz, 292 Hz, and 9,000 Hz were used in experiments. Monitoring of secretory IgA and albumin level in saliva and changes in bone density were used as objective markers of biostimulatory effect. SUMMARY BACKGROUND DATA: From the literature, it is known that if the alveolus is irradiated after extraction along with the lingual and buccal bony wall, faster coagulation, less postoperative discomfort, and quicker healing can be expected. METHODS: Subjective evaluation of therapy was observed using a scale (from -, negative therapeutic effect, to ++++, excellent treatment effect). Changes of secretory immunoglobulin A (sIgA), albumin levels, and bone density were compared in a group of 150 patients (nonlaser therapy, 30 patients). RESULTS: Differences in levels of the saliva markers (sIgA and albumin) were found to be significant when comparing irradiated and nonirradiated groups, and in comparison with those groups irradiated by various modulatory frequencies. Significant differences were observed between the increase of sIgA res. albumin and subjective feelings during treatment. Bone density after extraction and 6 months after surgical treatment was examined using dental digital radiovisiography. No significant differences were detected between bone density in irradiated and nonirradiated groups, perhaps due to our therapy protocol. CONCLUSIONS: The low-level laser has no influence on the process of osseointegration. This effect was observed on fracture healing in rats using He-Ne laser radiation. We found no differences in the bone density when compared to the control group. FAU - Kucerová, H AU - Kucerová H AD - Institute of Dental Research, General Faculty Hospital, Prague, Czech Republic. FAU - Dostálová, T AU - Dostálová T FAU - Himmlova, L AU - Himmlova L FAU - Bártová, J AU - Bártová J FAU - Mazánek, J AU - Mazánek J LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Laser Med Surg JT - Journal of clinical laser medicine & surgery JID - 9006547 RN - 0 (Albumins) RN - 0 (Immunoglobulin A, Secretory) SB - D MH - Adolescent MH - Adult MH - Aged MH - Albumins/analysis MH - Bone Density/radiation effects MH - Humans MH - Immunoglobulin A, Secretory/analysis MH - *Laser Therapy MH - Middle Aged MH - Molar/*surgery MH - Postoperative Period MH - Saliva/chemistry MH - *Tooth Extraction MH - Wound Healing/*radiation effects EDAT- 2001/09/27 10:00 MHDA- 2001/10/19 10:01 CRDT- 2001/09/27 10:00 PHST- 2001/09/27 10:00 [pubmed] PHST- 2001/10/19 10:01 [medline] PHST- 2001/09/27 10:00 [entrez] PST - ppublish SO - J Clin Laser Med Surg. 2000 Dec;18(6):309-15. PMID- 26630719 OWN - NLM STAT- MEDLINE DCOM- 20151217 LR - 20151203 IS - 0895-8831 (Print) IS - 0895-8831 (Linking) VI - 8 IP - 4 DP - 1997 TI - Ketoprofen Dental Pain Study. PG - 103-6 AB - Ketoprofen is a nonsteroidal antiinflammatory drug, recently approved as an over-the-counter (OTC) analgesic at a 12.5 mg dosage strength. This is the first published study which explores the analgesic efficacy and safety of ketoprofen 12.5 mg in patients experiencing pain following the removal of impacted third molars. This study was single-dose, double-blind and randomized utilizing a 6-hour in-patient evaluation period. Patients ingested a single dose of ketoprofen 12.5 mg (n = 30), ketoprofen 37.5 mg (n = 32) or placebo (n = 15) when their post-surgical pain reached at least a moderate intensity on a 5-point categorical (CAT) scale and greater than 50 mm on a 100 mm visual analog scale (VAS). Measures of pain intensity and relief were gathered every 20 minutes for the first 2 hours, and then hourly from hours 3 through 6. Adverse drug reactions were also recorded as they occurred. Both dosages of ketoprofen were significantly more efficacious than placebo (two way ANOVAs, p < 0.05). For pain intensity difference (PID) and pain relief, the 12.5 mg dose exhibited statistical superiority from hours 1 through 3, while the 37.5 mg dose exhibited statistical superiority from 40 minutes through 4 hours. Ketoprofen 37.5 mg was significantly more efficacious than the 12.5 mg dose only at 40 minutes for PID(VAS) and relief, and at 60 minutes for PID(VAS). Both ketoprofen dosages displayed significantly greater 3-hr, 4-hr and 6-hr summary analgesic measures (SPID(VAS), SPID(CAT), TOTPAR) than placebo, with the exception of the 6-hr SPID(CAT) measure for ketoprofen 12.5 mg. No serious side effects were observed in this study. We conclude that ketoprofen in a dose range of 12.5 mg to 37.5 mg is a safe and effective analgesic for the relief of post-operative dental pain. FAU - Levin, L M AU - Levin LM AD - University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA. FAU - Cooper, S A AU - Cooper SA FAU - Betts, N J AU - Betts NJ FAU - Wedell, D AU - Wedell D FAU - Hermann, D G AU - Hermann DG FAU - Lamp, C AU - Lamp C FAU - Secreto, S A AU - Secreto SA FAU - Hersh, E V AU - Hersh EV LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Dent JT - The Journal of clinical dentistry JID - 8904411 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Nonprescription Drugs) RN - 0 (Placebos) RN - 90Y4QC304K (Ketoprofen) SB - D MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects/*therapeutic use MH - Area Under Curve MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Follow-Up Studies MH - Humans MH - Ketoprofen/administration & dosage/adverse effects/*therapeutic use MH - Male MH - Molar, Third/surgery MH - Nonprescription Drugs/administration & dosage/therapeutic use MH - Operative Time MH - Pain Measurement/methods MH - Pain, Postoperative/*drug therapy MH - Placebos MH - Safety MH - Tooth Extraction/*methods MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Young Adult EDAT- 1997/01/01 00:00 MHDA- 2015/12/19 06:00 CRDT- 2015/12/04 06:00 PHST- 2015/12/04 06:00 [entrez] PHST- 1997/01/01 00:00 [pubmed] PHST- 2015/12/19 06:00 [medline] PST - ppublish SO - J Clin Dent. 1997;8(4):103-6. PMID- 22101161 OWN - NLM STAT- MEDLINE DCOM- 20120413 LR - 20161125 IS - 1879-114X (Electronic) IS - 0149-2918 (Linking) VI - 33 IP - 12 DP - 2011 Dec TI - Double-blind, placebo-controlled, randomized pilot study of cerebral blood flow patterns employing SPECT imaging in dental postsurgical pain patients with and without pain relief. PG - 1894-903 LID - 10.1016/j.clinthera.2011.10.013 [doi] AB - BACKGROUND: Single-photon emission computed tomography (SPECT) has been employed in the study of altered regional cerebral blood flow (CBF) in experimental and chronic pain. CBF patterns have not been evaluated in patients with acute postoperative pain. OBJECTIVE: The purpose of this pilot study was to employ SPECT to measure CBF distribution associated with postoperative dental pain and to compare these CBF patterns to subsequent images in the same patients who were experiencing pain relief versus continued or worsening pain who had received active or placebo analgesic interventions. The primary outcome measure was the percentage change in blood flow in various regions of interest. METHODS: Twenty-two healthy individuals (10 males and 12 females, age range 20-29 years) who underwent the removal of ≥1 partial or full bony impacted mandibular third molars were evaluated for pain intensity as the local anesthesia dissipated, employing a 0 to10 numeric rating scale (0 = no pain; 10 = worst imaginable). When the subjects' pain level reached ≥4/10, they were injected intravenously with 260 MBq of technetium Tc 99m bicisate (ethyl cysteinate dimer). Under double-blind conditions and 10 minutes before being placed in the SPECT scanner, the first 10 subjects were randomized to receive intravenous ketorolac 15 mg or saline while the remaining 12 subjects were randomized to receive by mouth either ibuprofen 400 mg, ibuprofen 200 mg, acetaminophen 1000 mg, or placebo. One hour after drug administration, subjects were reevaluated for pain, injected with 925 MBq of technetium Tc 99m bicisate, given rescue medication if required, and then rescanned. CBF ratios were obtained for regions of interest and by normalizing to average whole brain activity. RESULTS: Subjects generally had a moderate degree (mean [SD], 7.3% [4.0%]) of thalamic asymmetry on initial scans with pain; after treatment, subjects reporting worsening pain regardless of the intervention had higher thalamic asymmetry (8.1% vs 2.8%) than those reporting relief of pain. Subjects who reported reduced pain after the intervention had significantly different (P < 0.05) mean CBF changes compared with those reporting worsening pain in the left prefrontal cortex, left sensorimotor area, right anterior cingulate, and right caudate. CONCLUSIONS: Acute postoperative dental pain was associated with moderate thalamic asymmetry that improved following successful pain management. Sustained or worsening pain was associated with increased CBF in brain regions associated with pain pathways, whereas pain relief was associated with decreased activity in the same areas. CI - Copyright © 2011 Elsevier HS Journals, Inc. All rights reserved. FAU - Newberg, Andrew B AU - Newberg AB AD - Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Hersh, Elliot V AU - Hersh EV FAU - Levin, Lawrence M AU - Levin LM FAU - Giannakopoulos, Helen AU - Giannakopoulos H FAU - Secreto, Stacey A AU - Secreto SA FAU - Wintering, Nancy A AU - Wintering NA FAU - Farrar, John T AU - Farrar JT LA - eng GR - R21-AT000960/AT/NCCIH NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20111117 PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Analgesics) RN - 0 (Organotechnetium Compounds) RN - 0 (Placebos) RN - 0 (Radiopharmaceuticals) RN - H25WJA31XE (technetium Tc 99m bicisate) RN - K848JZ4886 (Cysteine) SB - IM MH - Acute Pain/diagnostic imaging/physiopathology/*prevention & control MH - Adult MH - Analgesics/*therapeutic use MH - Brain Mapping/*methods MH - *Cerebrovascular Circulation MH - Cysteine/analogs & derivatives MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Organotechnetium Compounds MH - Pain Measurement MH - Pain Perception MH - Pain, Postoperative/diagnostic imaging/physiopathology/*prevention & control MH - Pennsylvania MH - Pilot Projects MH - Placebos MH - Radiopharmaceuticals MH - Time Factors MH - *Tomography, Emission-Computed, Single-Photon MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Young Adult EDAT- 2011/11/22 06:00 MHDA- 2012/04/14 06:00 CRDT- 2011/11/22 06:00 PHST- 2011/10/17 00:00 [accepted] PHST- 2011/11/22 06:00 [entrez] PHST- 2011/11/22 06:00 [pubmed] PHST- 2012/04/14 06:00 [medline] AID - S0149-2918(11)00694-1 [pii] AID - 10.1016/j.clinthera.2011.10.013 [doi] PST - ppublish SO - Clin Ther. 2011 Dec;33(12):1894-903. doi: 10.1016/j.clinthera.2011.10.013. Epub 2011 Nov 17. PMID- 19751357 OWN - NLM STAT- MEDLINE DCOM- 20091211 LR - 20090915 IS - 1600-0501 (Electronic) IS - 0905-7161 (Linking) VI - 20 IP - 10 DP - 2009 Oct TI - Comparison of two resorbable membrane systems in bone regeneration after removal of wisdom teeth: a randomized-controlled clinical pilot study. PG - 1084-91 LID - 10.1111/j.1600-0501.2009.01751.x [doi] AB - OBJECTIVES: To compare the performance and safety of Inion GTR(TM) Biodegradable Membrane System and Geistlich resorbable bilayer Bio-Gide((R)) membrane in human bone regeneration. MATERIAL AND METHODS: In a multicenter, split blind, comparative, randomized, prospective, pilot study 15 patients have been randomized at surgery whether to be treated either with Inion GTR(TM) Biodegradable Membrane System on one and Geistlich resorbable bilayer Bio-Gide((R)) membrane on the other side or vice versa after surgical removal of both fully impacted wisdom teeth. During the follow-up visits at week 1, 2 and 6 and at months 3 and 6 the general state, the wound, eventual adverse events and the medication of the patients were assessed. Computed Tomography (CT) scans were performed immediately and 3 months after the surgery, before biopsy collection. Semi-quantitative histological evaluation and histomorphometric analyses were performed according to the ISO 10993-6 standard. New bone formation and membrane integration were evaluated by CT scan measurements. Tissue healing was evaluated clinically and by photographs between the time on teeth extraction and during follow ups. RESULTS: Five patients were smokers, none drank alcohol. Mild adverse events like wound infection, haematoma or late swelling of the gums occurred in three patients. The trephine bur harvest of bone biopsies under local anaesthesia was uneventful. Whereas specimens from the sites treated with the Inion membrane yielded 17.0% (SD 24%), the Bio-Gide membrane sites yielded 13.5% (SD 15%) of bone tissue density. In sites treated with the Inion membrane, 9.5% of old bone density and 7.5% of newly formed bone could be found, whereas the Bio-Gide((R)) membrane sites showed 3.8% of old bone density and 9.8% of newly formed bone. There were no statistically significant differences between the two groups with respect to the two variables. The osteoid rim was more extended with the Bio-Gide((R)) (6.6 mm) than with the Inion membrane (5.1 mm) but the difference between the two treatments did not reach statistical significance. Highly significant reductions in the area of the defect with both membranes were detected with significant increases in CT density at the immediate inferio-buccal adjacent bone and in the surgical defect area with both membranes. However, there was neither significant change in CT density in the immediate inferior-lingual adjacent bone of the two membranes, nor significant difference between the membranes on any of the four measurements (area of defect: P=0.1354; CT density immediate inferio-buccal adjacent bone: P=0.7615; CT density surgical defect area: P=0.1876; CT density immediate inferio-lingual adjacent bone: P=0.4212). CONCLUSION: The overall clinical outcome was satisfying and the majority of the patients showed an uneventful healing phase. Both membranes presented similar capacities regarding their barrier function and were associated with analogous bone regeneration. No statistically valid evidence about the superiority of one particular membrane was obtained. For the patient the only difference is that one product is animal derived and the other synthetic. FAU - Zwahlen, Roger A AU - Zwahlen RA AD - Department of Oral & Maxillofacial Surgery, Prince Philip Dental Hospital & Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR. zwahlen@hku.hk FAU - Cheung, Lim K AU - Cheung LK FAU - Zheng, Li-Wu AU - Zheng LW FAU - Chow, Raymond L K AU - Chow RL FAU - Li, Thomas AU - Li T FAU - Schuknecht, Bernhard AU - Schuknecht B FAU - Grätz, Klaus W AU - Grätz KW FAU - Weber, Franz E AU - Weber FE LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Denmark TA - Clin Oral Implants Res JT - Clinical oral implants research JID - 9105713 RN - 0 (Bio-Gide) RN - 0 (Biocompatible Materials) RN - 0 (Membranes, Artificial) RN - 0 (Polymers) RN - 9007-34-5 (Collagen) SB - D MH - Absorbable Implants MH - Adolescent MH - Adult MH - Alveolar Process/drug effects/*physiology MH - Alveolar Ridge Augmentation/methods MH - Biocompatible Materials/*therapeutic use MH - Bone Density/drug effects MH - Bone Regeneration/drug effects/*physiology MH - Collagen/therapeutic use MH - Female MH - Guided Tissue Regeneration, Periodontal/*methods MH - Humans MH - Male MH - *Membranes, Artificial MH - Molar, Third/surgery MH - Osteogenesis/drug effects/physiology MH - Pilot Projects MH - Polymers/therapeutic use MH - Prospective Studies MH - Single-Blind Method MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Treatment Outcome MH - Wound Healing/drug effects/physiology MH - Young Adult EDAT- 2009/09/16 06:00 MHDA- 2009/12/16 06:00 CRDT- 2009/09/16 06:00 PHST- 2009/09/16 06:00 [entrez] PHST- 2009/09/16 06:00 [pubmed] PHST- 2009/12/16 06:00 [medline] AID - CLR1751 [pii] AID - 10.1111/j.1600-0501.2009.01751.x [doi] PST - ppublish SO - Clin Oral Implants Res. 2009 Oct;20(10):1084-91. doi: 10.1111/j.1600-0501.2009.01751.x. PMID- 29908031 OWN - NLM STAT- MEDLINE DCOM- 20181224 LR - 20181224 IS - 1365-2842 (Electronic) IS - 0305-182X (Linking) VI - 45 IP - 9 DP - 2018 Sep TI - The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial. PG - 677-683 LID - 10.1111/joor.12679 [doi] AB - Curcumin is a turmeric-contained active ingredient that has been proven to be effective in treating pain and inflammation due to its analgesic as well as anti-inflammation potential. Odontectomy, on the other hand, has been well known for its post-procedure acute inflammation pain. The aim of the current study was to evaluate the efficacy of curcuminoid in treating acute inflammation post-operative pain in the post-surgical removal of impacted third molars patients. Ninety (44 males; 46 females) participants were recruited in this randomised controlled trial and randomly assigned to the control group (those who consumed mefenamic acid) or the experimental group (those who consumed curcumin). Numeric rating scale (NRS) was used as an evaluation tool to evaluate the intensity of the pain experienced by the participants. Pain evaluation was performed immediately after anaesthesia effect disappeared (T(0) ) and an hour after participant took their first (T(1) ), second (T(2) ) and third (T(3) ) course of drugs. All data were collected and analysed using Wilcoxon-Mann-Whitney test. The current study showed that participants in both groups experienced significantly (P < .01) less pain compared to their initial pain level. In addition, when the two groups were compared, it was revealed that those in the treatment group experienced even significantly (P < .01) less pain compared to those in the control group. It can be concluded that curcumin is effective in treating acute inflammation pain in the post-surgical removal of impacted third molars patients. CI - © 2018 John Wiley & Sons Ltd. FAU - Maulina, T AU - Maulina T AUID- ORCID: 0000-0002-6975-990X AD - Faculty of Dentistry, Oral Surgery Department, Universitas Padjadjaran, Bandung, Indonesia. FAU - Diana, H AU - Diana H AD - Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Cahyanto, A AU - Cahyanto A AD - Faculty of Dentistry, Dental Materials Science and Technology Department, Universitas Padjadjaran, Bandung, Indonesia. FAU - Amaliya, A AU - Amaliya A AD - Faculty of Dentistry, Periodontology Department, Universitas Padjadjaran, Bandung, Indonesia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180628 PL - England TA - J Oral Rehabil JT - Journal of oral rehabilitation JID - 0433604 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - IT942ZTH98 (Curcumin) SB - D SB - IM CIN - J Am Dent Assoc. 2019 Jan;150(1):e7. PMID: 30143229 MH - Adolescent MH - Adult MH - Aged MH - Analgesics/therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/pharmacology/*therapeutic use MH - Curcumin/pharmacology/*therapeutic use MH - Female MH - Humans MH - Inflammation/*drug therapy/physiopathology MH - Male MH - Middle Aged MH - *Molar, Third MH - Pain, Postoperative/*drug therapy/physiopathology MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - anti-inflammatory OT - curcumin OT - inflammation OT - oro-facial pain OT - surgical removal of impacted third molars EDAT- 2018/06/17 06:00 MHDA- 2018/12/26 06:00 CRDT- 2018/06/17 06:00 PHST- 2018/06/13 00:00 [accepted] PHST- 2018/06/17 06:00 [pubmed] PHST- 2018/12/26 06:00 [medline] PHST- 2018/06/17 06:00 [entrez] AID - 10.1111/joor.12679 [doi] PST - ppublish SO - J Oral Rehabil. 2018 Sep;45(9):677-683. doi: 10.1111/joor.12679. Epub 2018 Jun 28. PMID- 3304412 OWN - NLM STAT- MEDLINE DCOM- 19871020 LR - 20190912 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 25 IP - 4 DP - 1987 Aug TI - The influence of methylprednisolone on post-operative swelling following oral surgery. PG - 293-9 AB - This study compares the influence of methylprednisolone with that of a placebo on post-operative pain and swelling, and on healing. Twenty patients undergoing the removal of symmetrically placed bilateral lower third molar teeth under local analgesia by the same operator one side at a time were used. In each individual patient, for one side 40 mg methylprednisolone (Solumedrone Upjohn Limited) was given intravenously immediately preoperatively and for the other side a placebo was given on a double-blind random basis. The results showed that the mean post-operative swelling at 24 hours was reduced by 56% (p = .0003) when methylprednisolone was used compared with the opposite side of the same patient when the placebo was used. The severity of pain also was reduced over the first day but healing was similar for each side. Sixteen patients indicated a preference for the overall post-operative course when methylprednisolone was used. FAU - Holland, C S AU - Holland CS LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Placebos) RN - X4W7ZR7023 (Methylprednisolone) SB - D SB - IM MH - Adult MH - Clinical Trials as Topic MH - Double-Blind Method MH - Edema/etiology/*prevention & control MH - Female MH - Humans MH - Male MH - Methylprednisolone/*therapeutic use MH - Mouth Diseases/etiology/*prevention & control MH - Pain, Postoperative/prevention & control MH - Placebos MH - Postoperative Complications/*prevention & control MH - Tooth Extraction/*adverse effects MH - Wound Healing/drug effects EDAT- 1987/08/01 00:00 MHDA- 1987/08/01 00:01 CRDT- 1987/08/01 00:00 PHST- 1987/08/01 00:00 [pubmed] PHST- 1987/08/01 00:01 [medline] PHST- 1987/08/01 00:00 [entrez] AID - 10.1016/0266-4356(87)90068-4 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1987 Aug;25(4):293-9. doi: 10.1016/0266-4356(87)90068-4. PMID- 32718882 OWN - NLM STAT- MEDLINE DCOM- 20200917 LR - 20200917 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 48 IP - 9 DP - 2020 Sep TI - Intrasocket interventions to prevent alveolar osteitis after mandibular third molar surgery: A systematic review and network meta-analysis. PG - 902-913 LID - S1010-5182(20)30157-8 [pii] LID - 10.1016/j.jcms.2020.06.012 [doi] AB - A systematic review and network meta-analysis was carried out to assess the efficacy of different intrasocket interventions immediately after mandibular third molar surgery to prevent alveolar osteitis (AO). An electronic search was undertaken using EMBASE, Cochrane Library, MEDLINE/PubMed, Web of Science, Scopus, LILACS, and grey literature. We reviewed studies published up to September 2019 and included 37 randomized controlled trials (6175 mandibular third molar surgeries in 4716 patients). The pairwise meta-analysis showed that the incidence of AO decreased significantly when an intrasocket intervention was performed (risk ratio 0.39 [0.30, 0.52]; p < 0.0001). Platelet-rich fibrin (odds ratio 0.28; 95% CI [0.10, 0.71]), chlorhexidine gel 0.2% (0.52 [0.32, 0.95]), eugenol paste (0.06 [0.00, 0.77]), recombinant bovine growth factor (0.07 [0.00, 0.97]), colloidal silver gelatin sponge (0.05 [0.00, 0.74]), and acellular dermal matrix (0.04 [0.00, 0.74]) were significantly more effective than the placebo. Platelet-rich fibrin and chlorhexidine 0.2% gel had a large number of included studies and patients per comparison. Overall, there was moderate evidence to support the use of platelet-rich fibrin or chlorhexidine 0.2% gel in the socket for the prevention of AO after mandibular third molar surgery. CI - Copyright © 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Canellas, João Vitor Dos Santos AU - Canellas JVDS AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. Electronic address: drcanellas@icloud.com. FAU - Fraga, Samira Regina Guimarães AU - Fraga SRG AD - Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. FAU - Santoro, Monike Fernandes AU - Santoro MF AD - Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. FAU - Netto, Juliana de Noronha Santos AU - Netto JNS AD - Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. FAU - Tinoco, Eduardo Muniz Barretto AU - Tinoco EMB AD - Department of Periodontology, Faculty of Dentistry, Rio de Janeiro State University, Rua Boulevard 28 de Setembro, 157 Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20200708 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Animals MH - Cattle MH - Chlorhexidine MH - *Dry Socket MH - Humans MH - Molar MH - Molar, Third MH - Tooth Extraction MH - *Tooth, Impacted OTO - NOTNLM OT - Alveolar osteitis OT - Dry socket OT - Evidence-based dentistry OT - Network meta-analysis OT - Third molar EDAT- 2020/07/29 06:00 MHDA- 2020/09/18 06:00 CRDT- 2020/07/29 06:00 PHST- 2019/12/12 00:00 [received] PHST- 2020/05/18 00:00 [revised] PHST- 2020/06/28 00:00 [accepted] PHST- 2020/07/29 06:00 [pubmed] PHST- 2020/09/18 06:00 [medline] PHST- 2020/07/29 06:00 [entrez] AID - S1010-5182(20)30157-8 [pii] AID - 10.1016/j.jcms.2020.06.012 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2020 Sep;48(9):902-913. doi: 10.1016/j.jcms.2020.06.012. Epub 2020 Jul 8. PMID- 29898059 OWN - NLM STAT- MEDLINE DCOM- 20181211 LR - 20181211 IS - 1806-4760 (Electronic) IS - 0103-6440 (Linking) VI - 29 IP - 2 DP - 2018 Mar-Apr TI - Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal. PG - 140-149 LID - S0103-64402018000200140 [pii] LID - 10.1590/0103-6440201802254 [doi] AB - In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d). FAU - Simoneti, Luis Fernando AU - Simoneti LF AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Weckwerth, Giovana Maria AU - Weckwerth GM AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Dionísio, Thiago José AU - Dionísio TJ AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Torres, Elza Araujo AU - Torres EA AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Zupelari-Gonçalves, Paulo AU - Zupelari-Gonçalves P AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Calvo, Adriana Maria AU - Calvo AM AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Lauris, José Roberto AU - Lauris JR AD - Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Faria, Flávio Cardoso AU - Faria FC AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. FAU - Santos, Carlos Ferreira AU - Santos CF AD - Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Brazil TA - Braz Dent J JT - Brazilian dental journal JID - 9214652 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Proton Pump Inhibitors) RN - 90Y4QC304K (Ketoprofen) RN - KG60484QX9 (Omeprazole) SB - D MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/pharmacokinetics/*therapeutic use MH - Cross-Over Studies MH - Drug Therapy, Combination MH - Female MH - Humans MH - Inflammation/*prevention & control MH - Ketoprofen/administration & dosage/pharmacokinetics/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Omeprazole/administration & dosage/pharmacokinetics/*therapeutic use MH - Pain Management/*methods MH - Pain, Postoperative/*drug therapy MH - Proton Pump Inhibitors/administration & dosage/pharmacology/*therapeutic use MH - Tooth Extraction/*adverse effects MH - Trismus/prevention & control MH - Young Adult EDAT- 2018/06/14 06:00 MHDA- 2018/12/12 06:00 CRDT- 2018/06/14 06:00 PHST- 2018/01/11 00:00 [received] PHST- 2018/03/18 00:00 [accepted] PHST- 2018/06/14 06:00 [entrez] PHST- 2018/06/14 06:00 [pubmed] PHST- 2018/12/12 06:00 [medline] AID - S0103-64402018000200140 [pii] AID - 10.1590/0103-6440201802254 [doi] PST - ppublish SO - Braz Dent J. 2018 Mar-Apr;29(2):140-149. doi: 10.1590/0103-6440201802254. PMID- 9390478 OWN - NLM STAT- MEDLINE DCOM- 19971218 LR - 20170214 IS - 0022-0345 (Print) IS - 0022-0345 (Linking) VI - 76 IP - 12 DP - 1997 Dec TI - Arrest of root surface caries in situ. PG - 1845-53 AB - This study tests the hypothesis that daily oral hygiene combined with topical fluoride arrests active root-surface caries lesions without changing the mineral content of the lesions. Therefore, changes in mineral content and distribution were studied in root surfaces during caries lesion development and subsequent arrest of lesion progression in situ. In 18 subjects, lesions were developed during 3 months in sound root-surface specimens inserted into lower partial dentures. After 3 months, ground sections were prepared from each lesion prior to re-insertion of the specimens into the dentures. In addition, one sound root specimen was added per subject. During the following 3 months, half of the subjects cleaned both sound and carious specimens once a day with an 1100-ppm fluoride toothpaste, and the specimens were treated twice with 2% NaF for 2 min in situ. The other half of the subjects continued the experiment without cleaning. During the initial three-month period, all specimens developed subsurface lesions extending 187 to 583 microm into the dentin. Lesion depth increased somewhat in both experimental groups during the following 3 months (P > or = 0.1). There was a non-significant increase in mineral loss in the plaque-covered specimens (P = 0.08). However, the total mineral content of specimens subjected to plaque removal and topical fluoride did not change. This treatment resulted in an increased mineral content in the surface layer (P < 0.01) and formation of a zone of higher mineral content within the body of the lesion. The sound root surfaces which had been cleaned for a three-month period showed mineral uptake in the surface layer, occasionally associated with subsurface demineralization extending 20 to 70 microm into the tissue. The mineral loss of these specimens was significantly smaller than that of plaque-covered surfaces (P < 0.001). It is concluded that daily plaque removal and topical fluoride use influence the distribution of mineral in sound and carious root surfaces and may arrest lesion progression without affecting the total mineral content. FAU - Nyvad, B AU - Nyvad B AD - Department of Dental Pathology, Operative Dentistry and Endodontics, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark. FAU - ten Cate, J M AU - ten Cate JM FAU - Fejerskov, O AU - Fejerskov O LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 RN - 0 (Fluorides, Topical) RN - 0 (Toothpastes) RN - Q80VPU408O (Fluorides) SB - D SB - IM MH - Aged MH - Denture, Partial MH - Female MH - Fluorides/therapeutic use MH - Fluorides, Topical/administration & dosage MH - Humans MH - Male MH - Mandible MH - Microradiography MH - Middle Aged MH - Molar, Third MH - Research Design MH - Root Caries/diagnostic imaging/*therapy MH - Time Factors MH - Tooth Demineralization/diagnostic imaging/therapy MH - Tooth Remineralization MH - Toothpastes/therapeutic use EDAT- 1997/12/09 00:00 MHDA- 1997/12/09 00:01 CRDT- 1997/12/09 00:00 PHST- 1997/12/09 00:00 [pubmed] PHST- 1997/12/09 00:01 [medline] PHST- 1997/12/09 00:00 [entrez] AID - 10.1177/00220345970760120701 [doi] PST - ppublish SO - J Dent Res. 1997 Dec;76(12):1845-53. doi: 10.1177/00220345970760120701. PMID- 1078619 OWN - NLM STAT- MEDLINE DCOM- 19750421 LR - 20190616 IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 240 DP - 1975 Jan 20 TI - The therapeutic role of epsilon-aminocaproic acid (EACA) for dental extractions in hemophiliacs. PG - 267-76 AB - The results of a double-blind controlled trial, previously reported, showed that EACA is a useful adjunct to preoperative therapeutic concentrates of factor VIII or IX for dental extractions in hemophilia and Christmas disease. To estimate the amount of factor VIII and IX conserved in hemophiliacs receiving EACA for dental surgery compared with those not receiving EACA we have surveyed the usage of therapeutic materials in ten hemophilia centers in the U.S. and at Oxford. The amount of postoperative factor-VIII containing materials given to 20 U.S. hemophiliacs not receiving EACA averaged 11 062 units of factor-VIII activity per patient; 4,146 units for each of 22 U.S. patients receiving EACA; and 717 units for each of 56 patients at Oxford receiving EACA. Conservation of factor-IX-containing material was not as great. At Oxford 62.5% of patients receiving preoperative factor-VIII or -IX concentrates sufficient to raise the deficient factor to 50% of normal together with EACA, 24 g per day for ten days, required no postoperative therapeutic materials to control bleeding. The remainder required an average of two postoperative doses to control bleeding. FAU - Walsh, P N AU - Walsh PN FAU - Rizza, C R AU - Rizza CR FAU - Evans, B E AU - Evans BE FAU - Aledort, L M AU - Aledort LM LA - eng PT - Journal Article PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 RN - 0 (Aminocaproates) RN - 9001-27-8 (Factor VIII) RN - 9001-28-9 (Factor IX) SB - IM MH - Adult MH - Aminocaproates/*therapeutic use MH - Factor IX/therapeutic use MH - Factor VIII/therapeutic use MH - *Hemophilia A/drug therapy MH - Hemophilia B/drug therapy MH - Humans MH - Male MH - Oral Hemorrhage/*prevention & control MH - Postoperative Care MH - Preoperative Care MH - *Tooth Extraction EDAT- 1975/01/20 00:00 MHDA- 1975/01/20 00:01 CRDT- 1975/01/20 00:00 PHST- 1975/01/20 00:00 [pubmed] PHST- 1975/01/20 00:01 [medline] PHST- 1975/01/20 00:00 [entrez] AID - 10.1111/j.1749-6632.1975.tb53359.x [doi] PST - ppublish SO - Ann N Y Acad Sci. 1975 Jan 20;240:267-76. doi: 10.1111/j.1749-6632.1975.tb53359.x. PMID- 20080382 OWN - NLM STAT- MEDLINE DCOM- 20100610 LR - 20161209 IS - 2213-0276 (Electronic) IS - 0755-4982 (Linking) VI - 39 IP - 5 DP - 2010 May TI - [Treating pain after dental surgery: a randomised, controlled, double-blind trial to assess a new formulation of paracetamol, opium powder and caffeine versus tramadol or placebo]. PG - e103-11 LID - 10.1016/j.lpm.2009.09.025 [doi] AB - BACKGROUND: The aim of this study was to evaluate the analgesic efficacy and the safety of the association, paracetamol, opium prepared and caffeine, in two different dosages as compared to the conventional analgesic tramadol hydrochloride, on acute postoperative dental pain. METHODS: We conducted a randomised, double-blind, multicentre, parallel-group clinical trial to test the efficacy and safety of single doses of two associations; paracetamol 500 mg, caffeine 50mg, opium prepared 25, and paracetamol 500 mg, caffeine 50mg, opium prepared 50mg, as compared to tramadol hydrochloride 100mg (called hereafter tramadol 100), and placebo, in the control of postoperative pain following the removal of 2 ipsilateral impacted third molars. The primary efficacy criterion was the sum of pain intensity differences as assessed every 30 minutes within 3 hours after the baseline assessment and administration of study treatment (SPID(0-3h)). RESULTS: Of the 232 randomised patients, 228 (98%) completed the study. Analysis of the primary efficacy criterion (SPID(0-3h)) established: (i) the superiority of the 3 active study treatments vs. placebo (p<0.005); (ii) non-inferiority of paracetamol, caffeine, and opium 25mg, and paracetamol, caffeine, and opium 50mg vs. tramadol. Besides, both formulations of paracetamol, caffeine, and opium showed: (i) a faster onset of analgesic effect as compared to tramadol 100; (ii) a significantly stronger analgesic efficacy than tramadol 100, as measured 1 hour after the treatment intake; this superiority lasted all over the study duration for paracetamol, caffeine, and opium 50mg but not for paracetamol, caffeine, and opium 25mg. No unexpected safety concerns occurred, the two formulations of paracetamol, caffeine, and opium showed a good safety profile especially with paracetamol, caffeine, and opium 25mg as compared to tramadol. DISCUSSION: This study evidenced the non-inferiority of the paracetamol, caffeine, and opium 25mg or 50mg vs. tramadol 100, and even though the strengths of the tested formulations were higher than that of the 2009, commercialised formulation of paracetamol, caffeine, and opium, efficacy was not offset by an alteration of the well recognised safety profile of the less strengthened formulation of the product being in use for decades. CI - Copyright 2009 Elsevier Masson SAS. All rights reserved. FAU - Borel, Jean-François AU - Borel JF AD - CHU de Clermont-Ferrand, 63000 Clermont-Ferrand, France. FAU - Deschaumes, Christophe AU - Deschaumes C FAU - Devoize, Laurent AU - Devoize L FAU - Huard, Cédric AU - Huard C FAU - Orliaguet, Thierry AU - Orliaguet T FAU - Dubray, Claude AU - Dubray C FAU - Baudet-Pommel, Martine AU - Baudet-Pommel M FAU - Dallel, Radhouane AU - Dallel R LA - fre PT - Comparative Study PT - English Abstract PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial TT - Traitement de la douleur après avulsion dentaire : essai clinique randomisé en double aveugle comparant deux formulations de paracétamol, caféine et poudre d'opium versus tramadol et placebo. DEP - 20100118 PL - France TA - Presse Med JT - Presse medicale (Paris, France : 1983) JID - 8302490 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Central Nervous System Stimulants) RN - 0 (Drug Combinations) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - 39J1LGJ30J (Tramadol) RN - 3G6A5W338E (Caffeine) RN - 8008-60-4 (Opium) SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Analgesics, Non-Narcotic/administration & dosage/*therapeutic use MH - Analgesics, Opioid/administration & dosage/*therapeutic use MH - Caffeine/administration & dosage/*therapeutic use MH - Central Nervous System Stimulants/administration & dosage/*therapeutic use MH - Chemistry, Pharmaceutical MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Molar, Third/surgery MH - Opium/administration & dosage/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Placebos MH - Safety MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Tramadol/*therapeutic use MH - Treatment Outcome MH - Young Adult EDAT- 2010/01/19 06:00 MHDA- 2010/06/11 06:00 CRDT- 2010/01/19 06:00 PHST- 2009/04/03 00:00 [received] PHST- 2009/07/10 00:00 [revised] PHST- 2009/09/25 00:00 [accepted] PHST- 2010/01/19 06:00 [entrez] PHST- 2010/01/19 06:00 [pubmed] PHST- 2010/06/11 06:00 [medline] AID - S0755-4982(09)00559-4 [pii] AID - 10.1016/j.lpm.2009.09.025 [doi] PST - ppublish SO - Presse Med. 2010 May;39(5):e103-11. doi: 10.1016/j.lpm.2009.09.025. Epub 2010 Jan 18. PMID- 2287558 OWN - NLM STAT- MEDLINE DCOM- 19910325 LR - 20131121 IS - 0277-0008 (Print) IS - 0277-0008 (Linking) VI - 10 IP - 6 DP - 1990 TI - Evaluation of aspirin, caffeine, and their combination in postoperative oral surgery pain. PG - 387-93 AB - Three hundred fifty outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive a single oral dose of aspirin 650 or 1000 mg, caffeine 65 mg, a combination of aspirin 650 mg with caffeine 65 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. Estimates of summed pain intensity difference, peak pain intensity difference, total relief, peak relief, and hours of 50% relief were derived from these subjective reports. All active treatments except caffeine were significantly superior to placebo. Pairwise comparisons indicated the aspirin-caffeine combination was statistically superior to aspirin 650 mg alone for hours of 50% relief among patients who had severe baseline pain. Adverse effects were transitory and none were serious. FAU - Forbes, J A AU - Forbes JA AD - Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Jones, K F AU - Jones KF FAU - Kehm, C J AU - Kehm CJ FAU - Smith, W K AU - Smith WK FAU - Gongloff, C M AU - Gongloff CM FAU - Zeleznock, J R AU - Zeleznock JR FAU - Smith, J W AU - Smith JW FAU - Beaver, W T AU - Beaver WT FAU - Kroesen, M AU - Kroesen M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 3G6A5W338E (Caffeine) RN - R16CO5Y76E (Aspirin) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Aspirin/administration & dosage/adverse effects/*therapeutic use MH - Caffeine/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - Evaluation Studies as Topic MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar, Third MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] PST - ppublish SO - Pharmacotherapy. 1990;10(6):387-93. PMID- 20144497 OWN - NLM STAT- MEDLINE DCOM- 20100504 LR - 20161125 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 68 IP - 5 DP - 2010 May TI - Scintigraphic evaluation of osteoblastic activity in extraction sockets treated with platelet-rich fibrin. PG - 980-9 LID - 10.1016/j.joms.2009.09.092 [doi] AB - PURPOSE: To evaluate the effect of platelet-rich fibrin (PRF) on the early bone healing process with bone scintigraphy based on technetium-99m methylene diphosphonate uptake in third molar extraction sockets. PATIENTS AND METHODS: Fourteen patients with bilaterally soft tissue impacted third mandibular molars were included in the study. The right and left impacted third molars were surgically extracted in the same session. PRF was randomly administered into one of the extraction sockets, whereas the contralateral sockets were left without treatment. Four weeks after surgery, scintigrams were obtained to evaluate scintigraphic differences between PRF-treated and non-PRF-treated sockets. After completion of the clinical study, PRF samples were evaluated by light and scanning electron microscopy. RESULTS: The average increase in technetium-99m methylene diphosphonate uptake as an indication of enhanced bone healing did not differ significantly between PRF-treated and non-PRF-treated sockets 4 weeks postoperatively (P > .05). Abundant fibrin and inflammatory cells were observed by light microscopic examination of PRF samples. Scanning electron microscopic analysis of PRF revealed the existence of platelet aggregates in a fibrin network and crystalline particles on the outer surface of PRF. CONCLUSIONS: PRF might not lead to enhanced bone healing in soft tissue impacted mandibular third molar extraction sockets 4 weeks after surgery. PRF exhibits the potential characteristics of an autologous fibrin matrix. However, whether the presence of crystal-like particles on the outer surface of PRF alters bone healing should be investigated further. CI - Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Gürbüzer, Bahadir AU - Gürbüzer B AD - Department of Dentistry, Section of Oral and Maxillofacial Surgery, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. FAU - Pikdöken, Levent AU - Pikdöken L FAU - Tunali, Mustafa AU - Tunali M FAU - Urhan, Muammer AU - Urhan M FAU - Küçükodaci, Zafer AU - Küçükodaci Z FAU - Ercan, Feriha AU - Ercan F LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20100207 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Radiopharmaceuticals) RN - 9001-31-4 (Fibrin) RN - X89XV46R07 (Technetium Tc 99m Medronate) SB - AIM SB - D SB - IM MH - Adult MH - Blood Platelets/*physiology MH - Female MH - Fibrin/*therapeutic use MH - Follow-Up Studies MH - Humans MH - Male MH - Microscopy, Electron, Scanning MH - Molar, Third/surgery MH - Osteoblasts/diagnostic imaging/*physiology MH - Osteogenesis/physiology MH - Pericoronitis/surgery MH - Platelet Aggregation/physiology MH - Radionuclide Imaging MH - Radiopharmaceuticals MH - Technetium Tc 99m Medronate MH - *Tooth Extraction MH - Tooth Socket/diagnostic imaging/*physiology MH - Tooth, Impacted/surgery MH - Wound Healing/physiology MH - Young Adult EDAT- 2010/02/11 06:00 MHDA- 2010/05/05 06:00 CRDT- 2010/02/11 06:00 PHST- 2009/05/23 00:00 [received] PHST- 2009/09/01 00:00 [revised] PHST- 2009/09/23 00:00 [accepted] PHST- 2010/02/11 06:00 [entrez] PHST- 2010/02/11 06:00 [pubmed] PHST- 2010/05/05 06:00 [medline] AID - S0278-2391(09)01834-5 [pii] AID - 10.1016/j.joms.2009.09.092 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2010 May;68(5):980-9. doi: 10.1016/j.joms.2009.09.092. Epub 2010 Feb 7. PMID- 9063757 OWN - NLM STAT- MEDLINE DCOM- 19970528 LR - 20131121 IS - 0251-1649 (Print) IS - 0251-1649 (Linking) VI - 16 IP - 2-3 DP - 1996 TI - Comparison of the analgesic effects of diflunisal and paracetamol in the treatment of postoperative dental pain. PG - 57-65 AB - The search for new effective analgesics without unwanted effects on the coagulation mechanism and a longer duration of activity has been intensified. One such development is diflunisal and the aim of this study was to compare the analgesic effect of diflunisal with that of paracetamol. A combined single dose (500-mg tablets), double-blind, randomized, controlled design in out-patients (n = 104) with moderate or severe pain caused by the surgical removal of impacted mandibular third molars was used in this study. Pain intensity and relief were assessed postoperatively for 8h using category-rating scales. The results showed a statistically significant difference in favour of diflunisal in each and every parameter used in determining the efficacy of the treatment. FAU - Selçuk, E AU - Selçuk E AD - Department of Oral and Maxillofacial Surgery, Ege University, Izmir, Turkey. FAU - Gomel, M AU - Gomel M FAU - Bellibas, S E AU - Bellibas SE FAU - Köse, T AU - Köse T FAU - Tuğlular, I AU - Tuğlular I LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Switzerland TA - Int J Clin Pharmacol Res JT - International journal of clinical pharmacology research JID - 8110183 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 362O9ITL9D (Acetaminophen) RN - 7C546U4DEN (Diflunisal) SB - IM MH - Acetaminophen/*therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Diflunisal/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain, Postoperative/*drug therapy MH - *Tooth Extraction EDAT- 1996/01/01 00:00 MHDA- 1996/01/01 00:01 CRDT- 1996/01/01 00:00 PHST- 1996/01/01 00:00 [pubmed] PHST- 1996/01/01 00:01 [medline] PHST- 1996/01/01 00:00 [entrez] PST - ppublish SO - Int J Clin Pharmacol Res. 1996;16(2-3):57-65. PMID- 6777315 OWN - NLM STAT- MEDLINE DCOM- 19810219 LR - 20191031 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 9 IP - 3 DP - 1980 Jun TI - Value of penicillin in the prevention of pain, swelling and trismus following the removal of ectopic mandibular third molars. PG - 166-72 AB - A double-blind randomised placebo-controlled study of the value of systemic penicillin in preventing pain, swelling and trismus following the removal of impacted mandibular third molars and indicates that penicillin may be used justifiably in the more difficult cases. FAU - Macgregor, A J AU - Macgregor AJ FAU - Addy, A AU - Addy A LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Placebos) RN - 17R794ESYN (Penicillin G Procaine) RN - Q42T66VG0C (Penicillin G) RN - Z61I075U2W (Penicillin V) SB - D SB - IM MH - Clinical Trials as Topic MH - Double-Blind Method MH - Edema/prevention & control MH - Humans MH - Molar/surgery MH - Pain, Postoperative/prevention & control MH - Penicillin G/*therapeutic use MH - Penicillin G Procaine/*therapeutic use MH - Penicillin V/therapeutic use MH - Placebos MH - Postoperative Complications/*prevention & control MH - Random Allocation MH - Tooth Eruption, Ectopic/*surgery MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Trismus/prevention & control EDAT- 1980/06/01 00:00 MHDA- 1980/06/01 00:01 CRDT- 1980/06/01 00:00 PHST- 1980/06/01 00:00 [pubmed] PHST- 1980/06/01 00:01 [medline] PHST- 1980/06/01 00:00 [entrez] AID - 10.1016/s0300-9785(80)80015-9 [doi] PST - ppublish SO - Int J Oral Surg. 1980 Jun;9(3):166-72. doi: 10.1016/s0300-9785(80)80015-9. PMID- 12139269 OWN - NLM STAT- MEDLINE DCOM- 20021118 LR - 20201208 IS - 0045-0421 (Print) IS - 0045-0421 (Linking) VI - 47 IP - 2 DP - 2002 Jun TI - Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: a randomized, double-blind, prospective trial. PG - 147-51 AB - BACKGROUND: Codeine is frequently added to paracetamol to treat post-operative dento-alveolar pain; studies have shown effectiveness in relief of post-operative pain at high doses but at the expense of central nervous and gastrointestinal side effects. There has been no trial to compare the efficacy and safety of paracetamol 1000 mg with paracetamol 1000 mg combined with codeine 30 mg. METHOD: A randomized, single centre, double-blind prospective parallel group trial was performed to compare paracetamol 1000 mg with paracetamol 1000 mg with codeine 30 mg for the relief of pain following surgical removal of impacted third molars, and analysed on an intention-to-treat (ITT) basis. Eighty-two patients were assigned randomly to receive either drug for a maximum of three doses. Patients recorded their pain intensity one hour after surgery and hourly thereafter for 12 hours. RESULTS: The average increase in pain intensity over 12 hours was significantly less in patients receiving paracetamol plus codeine than in those receiving paracetamol alone (p=0.03) -1.81 cm/h compared with 0.45 cm/h - a difference of 1.13 cm/h (95 per cent CI: 0.18 to 2.08). Of the patients who received the paracetamol codeine combination, 62 per cent used escape medication compared with 75 per cent of those on paracetamol alone (p=0.20). There was no significant difference between the two groups in the proportion of patients experiencing adverse events (p=0.5). CONCLUSION: A combination of 1000 mg paracetamol and 30 mg codeine was significantly more effective in controlling pain for 12 hours following third molar removal, with no significant difference of side effects during the 12 hour period studied. FAU - Macleod, A Gordon AU - Macleod AG AD - School of Dentistry, The University of Queensland, Brisbane. a.macleod@mailbox.uq.edu.au FAU - Ashford, B AU - Ashford B FAU - Voltz, M AU - Voltz M FAU - Williams, B AU - Williams B FAU - Cramond, T AU - Cramond T FAU - Gorta, L AU - Gorta L FAU - Simpson, J M AU - Simpson JM LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Australia TA - Aust Dent J JT - Australian dental journal JID - 0370612 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D SB - IM MH - Acetaminophen/administration & dosage/adverse effects/*therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/adverse effects/*therapeutic use MH - Analgesics, Opioid/administration & dosage/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/therapeutic use MH - Chi-Square Distribution MH - Codeine/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/administration & dosage/therapeutic use MH - Male MH - Molar, Third/surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy/prevention & control MH - Prospective Studies MH - Safety MH - Statistics, Nonparametric MH - *Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery MH - Treatment Outcome EDAT- 2002/07/26 10:00 MHDA- 2002/11/26 04:00 CRDT- 2002/07/26 10:00 PHST- 2002/07/26 10:00 [pubmed] PHST- 2002/11/26 04:00 [medline] PHST- 2002/07/26 10:00 [entrez] AID - 10.1111/j.1834-7819.2002.tb00319.x [doi] PST - ppublish SO - Aust Dent J. 2002 Jun;47(2):147-51. doi: 10.1111/j.1834-7819.2002.tb00319.x. PMID- 16536204 OWN - NLM STAT- MEDLINE DCOM- 20060504 LR - 20131121 IS - 0361-7734 (Print) IS - 0361-7734 (Linking) VI - 31 IP - 1 DP - 2006 Jan-Feb TI - Effect of saliva contamination on the microshear bond strength of one-step self-etching adhesive systems to dentin. PG - 127-34 AB - This study evaluated the effect of saliva contamination and decontamination methods on the dentin bond strength of one-step self-etching adhesive systems. Three commercially available "all-in-one" adhesives (One Up Bond F, Xeno III and Adper Prompt) and one resin composite (Filtek Z-250) were used. Third molars stored in distilled water with 0.5% thymol at 4 degrees C were ground with #600 SiC paper under running water to produce a standardized smear layer. The specimens were randomly divided into groups according to contamination methods: no contamination, which was the control (C); contamination of the adhesive surface with fresh saliva before light curing (A) and contamination of the adhesive surface with fresh saliva after light curing (B). Each contamination group was further subdivided into three subgroups according to the decontamination method: A1-Saliva was removed by a gentle air blast and the adhesive was light-cured; A2-Saliva was rinsed for 10 seconds, gently air-dried and the was adhesive light-cured; A3-Saliva was rinsed and dried as in A2, then the adhesive was re-applied to the dentin surface and light-cured; B1-Saliva was removed with a gentle air blast; B2-Saliva was rinsed and dried; B3-Saliva was rinsed, dried and the adhesive was re-applied and light cured. Tygon tubes filled with resin composite were placed on each surface and light cured. All specimens were stored in distilled water at 37 degrees C for 24 hours. Microshear bond strength was measured using a universal testing machine (EZ test), and data were analyzed by one-way ANOVA followed by the Duncan test to make comparisons among the groups (p<0.05). After debonding, five specimens were selected and examined in a scanning electron microscope to evaluate the modes of fracture. The A2 subgroup resulted in the lowest bond strength. For One Up Bond F and Adper Prompt, there was no significant difference between subgroup A1 and the control, and subgroup A3 and the control (p>0.05). Bond strengths of all B groups were significantly lower compared to the controls (p<0.05). For Xeno III, A1 subgroup showed the greatest decrease in bond strength as compared to the control (p<0.05). On the other hand, it showed more resistance to salivary contamination after adhesive curing. There was no statistically significant difference among the control groups (p>0.05). FAU - Yoo, H M AU - Yoo HM AD - Department of Conservative Dentistry, The Institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Oh, T S AU - Oh TS FAU - Pereira, P N R AU - Pereira PN LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oper Dent JT - Operative dentistry JID - 7605679 RN - 0 (Composite Resins) RN - 0 (Dentin-Bonding Agents) RN - 0 (Filtek Z250) RN - 0 (Methacrylates) RN - 0 (One-Up-Bond F) RN - 0 (Prompt L-Pop) RN - 0 (Resin Cements) RN - 0 (Xeno III) RN - 059QF0KO0R (Water) SB - D MH - Air MH - Composite Resins/chemistry MH - Decontamination MH - *Dental Bonding MH - Dentin/*ultrastructure MH - Dentin-Bonding Agents/*chemistry MH - Humans MH - Light MH - Materials Testing MH - Methacrylates/chemistry MH - Microscopy, Electron, Scanning MH - Molar, Third MH - Resin Cements/chemistry MH - Saliva/*physiology MH - Shear Strength MH - Smear Layer MH - Stress, Mechanical MH - Surface Properties MH - Temperature MH - Time Factors MH - Water/chemistry EDAT- 2006/03/16 09:00 MHDA- 2006/05/05 09:00 CRDT- 2006/03/16 09:00 PHST- 2006/03/16 09:00 [pubmed] PHST- 2006/05/05 09:00 [medline] PHST- 2006/03/16 09:00 [entrez] AID - 10.2341/04-206 [doi] PST - ppublish SO - Oper Dent. 2006 Jan-Feb;31(1):127-34. doi: 10.2341/04-206. PMID- 815189 OWN - NLM STAT- MEDLINE DCOM- 19760602 LR - 20191028 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 4 IP - 6 DP - 1975 Dec TI - Anti-inflammatory and analgetic effects of indomethacin following removal of impacted mandibular third molars. PG - 267-76 AB - In a double-blind, clinical study, the analgetic and anti-inflammatory effects of indomethacin (Indocid) were evaluated following removal of impacted or semi-impacted mandibular third molars in 50 patients. Regarding analgetic effectiveness, 84% of the patients reported good or excellent relief from pain after administration of 50 mg of indomethacin three times a day for 2 days. The analgetic effect of indomethacin was significantly better than that of placebo. There was no significant difference in anti-inflammatory effectiveness between indomethacin and placebo. The degree of trismus postoperatively was significantly less in the indomethacin group. Due to a rather high incidence of side effects (28%) in the central nervous system and the gastrointestinal tract, the routine use of indomethacin in oral surgery is not recommended. FAU - Petersen, J K AU - Petersen JK LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Placebos) RN - XXE1CET956 (Indomethacin) SB - D SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - Clinical Trials as Topic MH - Female MH - Humans MH - Indomethacin/administration & dosage/adverse effects/*therapeutic use MH - Male MH - Middle Aged MH - Molar MH - Pain/drug therapy MH - Placebos MH - Surgical Wound Infection/prevention & control MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1975/12/01 00:00 MHDA- 1975/12/01 00:01 CRDT- 1975/12/01 00:00 PHST- 1975/12/01 00:00 [pubmed] PHST- 1975/12/01 00:01 [medline] PHST- 1975/12/01 00:00 [entrez] AID - 10.1016/s0300-9785(75)80044-5 [doi] PST - ppublish SO - Int J Oral Surg. 1975 Dec;4(6):267-76. doi: 10.1016/s0300-9785(75)80044-5. PMID- 1653313 OWN - NLM STAT- MEDLINE DCOM- 19911007 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 49 IP - 9 DP - 1991 Sep TI - Cardiohemodynamic and serum catecholamine response to surgical removal of impacted mandibular third molars under local anesthesia: a randomized double-blind parallel group and crossover study. PG - 957-62 AB - The aim of this study was to differentiate between the extent to which surgical stress and the epinephrine in local anesthetic solutions influence serum catecholamine, cAMP, and potassium levels, and contribute to changes in cardiohemodynamic parameters. One hundred sixty mg of articaine hydrochloride (4.0 mL of a 4% articaine hydrochloride solution) with two different epinephrine doses was injected into outpatients prior to removal of an impacted mandibular third molar in a randomized, double-blind parallel group and crossover design. The results showed that the amount of epinephrine absorbed from the intraoral injection site predominantly determined the serum epinephrine concentration. The anesthetic-induced increase in the serum epinephrine level did not correlate with changes in the cardiohemodynamic parameters under study at any time during the operative procedure. The serum cAMP changes correlated with those of epinephrine, whereas the serum potassium levels remained unchanged. The procedure of tooth extraction was a stressful event when the 1:200,000 epinephrine-containing anesthetic solution was used, showing that the risk of inducing a cardiovascular incident during oral surgery seems to be higher the greater the extent of operation and the lower the epinephrine dose in the anesthetic solution. FAU - Knoll-Köhler, E AU - Knoll-Köhler E AD - Freie Universität Berlin, Germany. FAU - Knöller, M AU - Knöller M FAU - Brandt, K AU - Brandt K FAU - Becker, J AU - Becker J LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Catecholamines) RN - D3SQ406G9X (Carticaine) RN - E0399OZS9N (Cyclic AMP) RN - RWP5GA015D (Potassium) RN - YKH834O4BH (Epinephrine) SB - AIM SB - D SB - IM MH - Adult MH - *Anesthesia, Dental MH - *Anesthesia, Local MH - Blood Pressure/*drug effects MH - Carticaine/administration & dosage MH - Catecholamines/blood MH - Cyclic AMP/blood MH - Double-Blind Method MH - Epinephrine/administration & dosage/blood/*pharmacology MH - Heart Rate/*drug effects MH - Hemodynamics/drug effects MH - Humans MH - Male MH - Molar, Third MH - Potassium/blood MH - Tooth Extraction MH - Tooth, Impacted/surgery EDAT- 1991/09/01 00:00 MHDA- 1991/09/01 00:01 CRDT- 1991/09/01 00:00 PHST- 1991/09/01 00:00 [pubmed] PHST- 1991/09/01 00:01 [medline] PHST- 1991/09/01 00:00 [entrez] AID - 0278-2391(91)90059-U [pii] AID - 10.1016/0278-2391(91)90059-u [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1991 Sep;49(9):957-62. doi: 10.1016/0278-2391(91)90059-u. PMID- 23882458 OWN - NLM STAT- MEDLINE DCOM- 20130912 LR - 20181023 IS - 1064-6655 (Print) IS - 1064-6655 (Linking) VI - 27 IP - 3 DP - 2013 Summer TI - Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. PG - 256-62 LID - 10.11607/jop.1142 [doi] AB - AIMS: To assess the effects of intra-alveolar application of chlorhexidine gel on the incidence of alveolar osteitis (dry socket) and the severity of postsurgical pain. METHODS: A total of 160 impacted mandibular third molars were extracted in 80 patients enrolled in this trial. In each subject, a socket was randomly selected and packed to the crest of the alveolar ridge with a gelatin sponge dressing saturated in 0.2% chlorhexidine gel. The contralateral socket was packed with a dry dressing as the placebo. None of the included patients took antibiotics or analgesics. The occurrence of dry socket and patients' pain levels were assessed at the first and third postoperative days. The data were analyzed using Spearman correlation coefficient, McNemar, Wilcoxon, and chi-square tests. RESULTS: Chlorhexidine gel significantly reduced dry socket incidence from 32.6% to 11.3% (P ≤ .001 [McNemar and chi-square], absolute risk reduction = 21.2%, relative risk reduction = 65.4%, odds ratio = 0.263, relative risk = 0.345). It also significantly relieved postoperative pain on both sides in all the patients (P ≤ .001 [Wilcoxon]) and also in the 54 subjects who did not develop dry socket (P ≤ .001 [Wilcoxon]). CONCLUSIONS: Besides decreasing the incidence of dry socket, chlorhexidine gel can reduce postsurgical pain in patients with and without dry socket. FAU - Haraji, Afshin AU - Haraji A AD - Department of Oral and Maxillofacial Surgery, Islamic Azad University, Tehran. Iran. FAU - Rakhshan, Vahid AU - Rakhshan V FAU - Khamverdi, Naiemeh AU - Khamverdi N FAU - Alishahi, Hadiseh Khanzadeh AU - Alishahi HK LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Orofac Pain JT - Journal of orofacial pain JID - 9418507 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Gels) RN - 0 (Tissue Adhesives) RN - R4KO0DY52L (Chlorhexidine) SB - D MH - Adolescent MH - Adult MH - Anti-Infective Agents, Local/*administration & dosage/therapeutic use MH - Chi-Square Distribution MH - Chlorhexidine/*administration & dosage/therapeutic use MH - Double-Blind Method MH - Dry Socket/etiology/*prevention & control MH - Female MH - Gels MH - Humans MH - Male MH - Molar, Third/surgery MH - Pain, Postoperative/etiology/*prevention & control MH - Risk Reduction Behavior MH - Statistics, Nonparametric MH - Tissue Adhesives/administration & dosage/therapeutic use MH - Tooth Extraction/*adverse effects MH - Tooth Socket/drug effects MH - Tooth, Impacted/surgery MH - Young Adult EDAT- 2013/07/25 06:00 MHDA- 2013/09/13 06:00 CRDT- 2013/07/25 06:00 PHST- 2013/07/25 06:00 [entrez] PHST- 2013/07/25 06:00 [pubmed] PHST- 2013/09/13 06:00 [medline] AID - 10.11607/jop.1142 [doi] PST - ppublish SO - J Orofac Pain. 2013 Summer;27(3):256-62. doi: 10.11607/jop.1142. PMID- 17062301 OWN - NLM STAT- MEDLINE DCOM- 20070111 LR - 20141120 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 28 IP - 9 DP - 2006 Sep TI - Analgesic efficacy of the cyclooxygenase-inhibiting nitric oxide donor AZD3582 in postoperative dental pain: Comparison with naproxen and rofecoxib in two randomized, double-blind, placebo-controlled studies. PG - 1279-95 AB - OBJECTIVE: This study assessed the analgesic efficacy of single doses of 4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl) propanoate (AZD3582) in acute postoperative dental pain after the removal of an impacted mandibular third molar (ie, wisdom tooth). METHODS: Two randomized, placebo-controlled, double-blind studies were performed. In a dose-finding study, 242 patients were randomized to AZD3582 375, 750, 1500, or 2250 mg (n = 41, 37, 42, and 41, respectively); naproxen 500 mg (n = 39); or placebo (n = 42). In a comparator study, 282 patients were randomized to AZD3582 500 mg (n = 78) or 750 mg (n = 83), rofecoxib 50 mg (n = 80), or placebo (n = 41). Primary outcomes included time to rescue medication, time to pain relief, and mean pain intensity difference (MPID), as well as safety profile. Pain was rated on a visual analog scale. RESULTS: In the dose-finding study, 52% (126/242) were women; the mean (SD) age was 25.1 (4) years, mean weight was 69.0 kg, and the mean (SD) body mass index (BMI) was 23.7 (3) kg/m2. In the comparator study, 58% (164/282) were women; the mean (SD) age was 27 (6.4) years, mean weight was 71 kg, and mean (SD) BMI was 24.2 (3) kg/m2. In the dose-finding study, the AZD3582 750-, 1500-, and 2250-mg groups were superior to placebo in the primary variables "time to rescue medication (0-8 hours)" (hazard ratios [HRs] [95% CIs], 0.17 [0.07-0.42], P < 0.003; 0.23 [0.11-0.50], P < 0.001; and 0.15 [0.06-0.36], P < 0.001, respectively), "time to meaningful pain relief" (HRs [95% CIs], 3.42 [1.87-6.25], P < 0.003; 2.49 [1.37-4.50], P < 0.003; and 3.07 [1.70-5.55], P < 0.001, respectively), and MPID (analysis of covariance [ANCOVA] least squares mean [LSM] differences [95% CIs], 25.8 [17.3-34.4], P < 0.003; 20.4 [12.1-28.7], P < 0.003; and 29.3 [20.9-37.6], P < 0.001, respectively). AZD3582 and naproxen did not show any statistically significant differences for the 3 primary variables, except that naproxen was superior to the AZD3582 375-mg dose for the variables time to meaningful pain relief (HR difference, 0.48 [95% CI, 0.29-0.78], P < 0.004) and MPID (difference in ANCOVA LSM, -10.2, [95% CI, -18.2 to -2.2], P < 0.012). The median times to meaningful pain relief were 115 minutes for AZD3582 375 mg, 66 minutes for 750 mg, 85 minutes for 1500 mg, 81 minutes for 2250 mg, and 162 minutes for placebo (P = NS, P = 0.003, P < 0.003, and P < 0.001, respectively). The median time to first rescue medication was 144 minutes for placebo, and <50% of the subjects on any of the AZD3582 doses or naproxen took rescue medication within 8 hours after dosing. In the comparator study, AZD3582 750 mg was superior to placebo in "time to rescue medication (0-24 hours)" (HR [95% CI], 0.4 [0.3-0.6], P < 0.001), "time to confirmed perceptible pain relief" (2.1 [1.1-3.8], P = 0.02), and MPID (11.9 [4.2-19.5], P = 0.002). However, inferiority of AZD3582 to rofecoxib for MPID could not be excluded (tolerance limit of 10 mm; P = NS for noninferiority testing). The median times to confirmed perceptible pain relief were 45 minutes for AZD3582 500 mg, 40 minutes for 750 mg, and 37 minutes for rofecoxib. The median times to first rescue medication were 218 minutes for AZD3582 500 mg, 365 minutes for 750 mg, 635 minutes for rofecoxib, and 90 minutes for placebo. Overall, AZD3582 was well tolerated. However, an effect on orthostatic blood pressure could not be excluded because there seemed to be more subjects with dizziness and orthostatic blood pressure reduction who were administered AZD3582 > or =750 mg. The proportions of patients with vertigo and decreased orthostatic blood pressure each group were as follows: AZD3582 500 mg, 6%; AZD3582 750 mg, 12%; rofecoxib, 3%; and placebo, 5%. CONCLUSIONS: AZD3582 750 mg had similar analgesic efficacy as equimolar doses of naproxen, but noninferiority to rofecoxib was not demonstrated. FAU - Michael Hill, C AU - Michael Hill C AD - University Dental Hospital, Heath Park, Cardiff, United Kingdom. hillcm@cardiff.ac.uk FAU - Sindet-Pederson, Steen AU - Sindet-Pederson S FAU - Seymour, Robin A AU - Seymour RA FAU - Hawkesford, John E 2nd AU - Hawkesford JE 2nd FAU - Coulthard, Paul AU - Coulthard P FAU - Lamey, Philip John AU - Lamey PJ FAU - Gerry Cowan, C AU - Gerry Cowan C FAU - Wickens, Mark AU - Wickens M FAU - Jeppsson, Lennart AU - Jeppsson L FAU - Dean, Andrew D P AU - Dean AD FAU - Svensson, Ola AU - Svensson O LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Cyclooxygenase Inhibitors) RN - 0 (Lactones) RN - 0 (Naphthalenes) RN - 0 (Sulfones) RN - 0 (naproxen-n-butyl nitrate) RN - 0QTW8Z7MCR (rofecoxib) RN - 57Y76R9ATQ (Naproxen) SB - IM MH - Adolescent MH - Adult MH - Cyclooxygenase Inhibitors/administration & dosage/*therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Humans MH - Lactones/administration & dosage/*therapeutic use MH - Male MH - Mandible/surgery MH - Middle Aged MH - Molar, Third/surgery MH - Naphthalenes/administration & dosage/*therapeutic use MH - Naproxen/administration & dosage/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*drug therapy/etiology MH - Sulfones/administration & dosage/*therapeutic use MH - *Tooth Extraction MH - Treatment Outcome EDAT- 2006/10/26 09:00 MHDA- 2007/01/12 09:00 CRDT- 2006/10/26 09:00 PHST- 2006/03/08 00:00 [accepted] PHST- 2006/10/26 09:00 [pubmed] PHST- 2007/01/12 09:00 [medline] PHST- 2006/10/26 09:00 [entrez] AID - S0149-2918(06)00222-0 [pii] AID - 10.1016/j.clinthera.2006.09.015 [doi] PST - ppublish SO - Clin Ther. 2006 Sep;28(9):1279-95. doi: 10.1016/j.clinthera.2006.09.015. PMID- 10388371 OWN - NLM STAT- MEDLINE DCOM- 19990708 LR - 20131121 IS - 0894-8275 (Print) IS - 0894-8275 (Linking) VI - 11 IP - 4 DP - 1998 Aug TI - Soluble calcium/SMFP dentifrice: effect on enamel fluoride uptake and remineralization. PG - 173-6 AB - PURPOSE: To evaluate in situ the effect of soluble calcium on fluoride uptake and remineralization by human dental enamel from a sodium monofluorophosphate (SMFP) dentifrice. MATERIALS AND METHODS: Eight volunteers took part in this cross-over, double-blind design study performed in three phases of 45 days. During each phase of the experiment, the subjects wore an acrylic resin appliance containing four blocks of human dental enamel with artificial caries to evaluate fluoride uptake and remineralization by three dentifrices: SMFP containing CaCl2, SMFP, and placebo. After each phase, the enamel blocks were removed and the total fluoride uptake (ppm F) and microhardness (Knoop) were measured. Statistical analyses (ANOVA and Turkey's test) were done. RESULTS: There was no statistically significant difference between SMFP-CaCl2 and SMFP treatments regarding the amount of fluoride and microhardness data of treated enamel blocks as well as their areas under the curves, although both differed significantly (P < 0.05) when they were compared with placebo. However, the SMFP-CaCl2 treatment demonstrated the highest values on fluoride uptake and microhardness data. Furthermore, the microhardness data demonstrated 50% and 40% of remineralization for SMFP-CaCl2 and SMFP dentifrices, respectively. FAU - Koo, R H AU - Koo RH AD - Faculty of Dentistry of Piracicaba, State University of Campinas-UNICAMP, Brazil. FAU - Cury, J A AU - Cury JA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Am J Dent JT - American journal of dentistry JID - 8806701 RN - 0 (Dentifrices) RN - 0 (Drug Combinations) RN - 0 (Phosphates) RN - 15181-43-8 (fluorophosphate) RN - M4I0D6VV5M (Calcium Chloride) RN - Q80VPU408O (Fluorides) SB - D MH - Analysis of Variance MH - Biological Availability MH - Calcium Chloride/*pharmacokinetics MH - Cross-Over Studies MH - Dental Enamel/*chemistry/metabolism MH - Dental Enamel Permeability MH - Dentifrices/chemistry/*pharmacokinetics MH - Double-Blind Method MH - Drug Combinations MH - Fluorides/chemistry/*pharmacokinetics MH - Hardness MH - Humans MH - Molar, Third MH - Phosphates/chemistry/*pharmacokinetics MH - Solubility MH - *Tooth Remineralization EDAT- 1999/07/01 00:00 MHDA- 1999/07/01 00:01 CRDT- 1999/07/01 00:00 PHST- 1999/07/01 00:00 [pubmed] PHST- 1999/07/01 00:01 [medline] PHST- 1999/07/01 00:00 [entrez] PST - ppublish SO - Am J Dent. 1998 Aug;11(4):173-6. PMID- 16977953 OWN - NLM STAT- MEDLINE DCOM- 20061109 LR - 20151119 IS - 1029-4864 (Print) IS - 1029-4864 (Linking) VI - 61 IP - 6 DP - 2006 Jul TI - Self-etching bonding systems: in-vitro micro-leakage evaluation. PG - 248, 250-1 AB - The purpose of this in vitro study was to compare dentine and enamel micro-leakage values of six self-etching bonding agents to that of a total etch dentine bonding agent (used as a control). Products evaluated were Scotchbond Multipurpose Plus (3M/ESPE), Xeno III (Dentsply), Clearfil SE Bond (Kuraray), ABF (Kuraray), Optibond Solo Self-Etch (Kerr), OneCoatSE Bond (Colténe Whaledent), and iBond (Heraeus-Kulzer). Using a medium sized Cerana bur (Nordiska Dental) a standard, cylindrical preparation was made at the cemento-enamel junction (CEJ) of human third molars. The teeth were randomly divided into 7 groups of ten teeth each. The bonding agents were applied and light cured strictly according to the manufacturer's instructions and the cavities then filled in two increments, using Z100 composite (3M/ESPE). The restored teeth were imbedded in acrylic resin and thermocycled between 5 degrees - 60 degrees C (+/- 2 degrees C) for 250 cycles with a dwell time of 20 seconds. All seven groups were then placed in a 5% basic Fuchsin solution for 12 hours at 37 degrees C. The embedded teeth were removed from the basic Fuchsin, rinsed well, imbedded in acrylic and cut longitudinally through the centre of each restoration using an Accutom-2 cutting machine. Each tooth was then evaluated at the occlusal enamel margin and at the cervical dentine margin for micro-leakage using a light microscope at 50x magnification. The data obtained was analysed using the Kruskal-Wallis test, with Fisher's least significant difference method used for comparison of specific groups (p<0.05). When compared to the control (Scotchbond Multipurpose Plus), results for microleakage at the occlusal enamel margins as well as the cervical dentine margins indicated that only SE Bond and ABF (Protect Bond) showed values as low as the control. It can be concluded that, as far as micro-leakage is concerned, Clearfil SE Bond and ABF (Protect Bond) self-etching bonding agents could be clinically acceptable alternatives to the clinically proven Scotch-bond Multipurpose. The other products showed more microleakage. FAU - Brandt, P D AU - Brandt PD AD - Division of Dental Materials, School of Dentistry, University of Pretoria, PO Box 1266, Pretoria. pbrandt@medic.up.ac.za FAU - de Wet, F A AU - de Wet FA FAU - du Preez, I C AU - du Preez IC LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - South Africa TA - SADJ JT - SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging JID - 9812497 RN - 0 (ABF Bond) RN - 0 (Clearfil SE Bond) RN - 0 (Coloring Agents) RN - 0 (Composite Resins) RN - 0 (Dentin-Bonding Agents) RN - 0 (Methacrylates) RN - 0 (One Coat Bond) RN - 0 (OptiBond Solo Plus Self-Etch) RN - 0 (Resin Cements) RN - 0 (Rosaniline Dyes) RN - 0 (Scotchbond Multi-Purpose Plus) RN - 0 (Xeno III) RN - 0 (Z100 composite resin) RN - 0 (iBond) RN - 7631-86-9 (Silicon Dioxide) RN - C6V6S92N3C (Zirconium) SB - D MH - Acid Etching, Dental/methods MH - Coloring Agents MH - Composite Resins/chemistry MH - *Dental Bonding MH - Dental Enamel/ultrastructure MH - Dental Leakage/*classification MH - Dentin/ultrastructure MH - Dentin-Bonding Agents/*chemistry MH - Humans MH - Materials Testing MH - Methacrylates/chemistry MH - Molar, Third MH - Resin Cements/chemistry MH - Rosaniline Dyes MH - Silicon Dioxide/chemistry MH - Tooth Cervix/ultrastructure MH - Zirconium/chemistry EDAT- 2006/09/19 09:00 MHDA- 2006/11/11 09:00 CRDT- 2006/09/19 09:00 PHST- 2006/09/19 09:00 [pubmed] PHST- 2006/11/11 09:00 [medline] PHST- 2006/09/19 09:00 [entrez] PST - ppublish SO - SADJ. 2006 Jul;61(6):248, 250-1. PMID- 3892406 OWN - NLM STAT- MEDLINE DCOM- 19850805 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 59 IP - 5 DP - 1985 May TI - Control of pain with meclofenamate sodium following removal of an impacted molar. PG - 446-8 AB - The analgesic effectiveness of meclofenamate sodium (Meclomen) at two dose levels, 200 mg and 100 mg, was compared with the effectiveness of a placebo and aspirin, 600 mg, in a double-blind study of 174 adult outpatients who had undergone removal of impacted third molars. When compared with the placebo, meclofenamate sodium at either dose level produced a significantly greater reduction in pain intensity, greater pain relief, fewer withdrawals for inefficacy, greater percentage of patients who considered their medication effective, and greater percentage of patients considered by the investigator to have received drug-attributable benefits. In comparison with aspirin, 600 mg, meclofenamate sodium at either 200 mg or 100 mg produced significantly greater reduction in pain intensity and greater pain relief. The other measures of efficacy showed no significant differences between the two drugs. Side effects were minimal in all treatment groups. Meclofenamate sodium appears to be a safe and effective analgesic for the control of pain. FAU - Rowe, N H AU - Rowe NH FAU - Aseltine, L F AU - Aseltine LF FAU - Turner, J L AU - Turner JL LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (ortho-Aminobenzoates) RN - 48I5LU4ZWD (Meclofenamic Acid) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Adolescent MH - Adult MH - Aspirin/therapeutic use MH - Clinical Trials as Topic MH - Double-Blind Method MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Meclofenamic Acid/*therapeutic use MH - Middle Aged MH - Pain, Postoperative/*drug therapy MH - Random Allocation MH - Tooth, Impacted/*surgery MH - ortho-Aminobenzoates/*therapeutic use EDAT- 1985/05/01 00:00 MHDA- 1985/05/01 00:01 CRDT- 1985/05/01 00:00 PHST- 1985/05/01 00:00 [pubmed] PHST- 1985/05/01 00:01 [medline] PHST- 1985/05/01 00:00 [entrez] AID - 10.1016/0030-4220(85)90078-7 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1985 May;59(5):446-8. doi: 10.1016/0030-4220(85)90078-7. PMID- 375153 OWN - NLM STAT- MEDLINE DCOM- 19790728 LR - 20190712 IS - 0030-4220 (Print) IS - 0030-4220 (Linking) VI - 47 IP - 6 DP - 1979 Jun TI - Evaluation of sedative/analgesic combination for postoperative pain. PG - 513-4 AB - Current pain concepts suggest a dual role in pain perception. Both motivational, effective, and somatosensory components are noted. Pain affects the patient's psyche and, conversely, the patient's state of mind modifies pain perception. Consequently, it might be expected that a sedative/analgesic combination might be more effective than either the sedative or the analgesic alone in controlling pain. A clinical study was carried out to compare a promethazine-A.P.C. combination with promethazine and A.P.C. alone. One hundred forty-nine patients undergoing third molar removal were studied, with each patient serving as his own control. The results indicated a significant difference between the promethazine-A.P.C. combination and prometazine alone or Phenergan alone. No significant difference was noted between the promethazine-A.P.C. combination and A.P.C. alone. FAU - Upton, L G AU - Upton LG LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Oral Surg Oral Med Oral Pathol JT - Oral surgery, oral medicine, and oral pathology JID - 0376406 RN - 0 (Drug Combinations) RN - 0 (Placebos) RN - 3G6A5W338E (Caffeine) RN - ER0CTH01H9 (Phenacetin) RN - FF28EJQ494 (Promethazine) RN - R16CO5Y76E (Aspirin) SB - D SB - IM MH - Anxiety/prevention & control MH - Aspirin/administration & dosage/*therapeutic use MH - Caffeine/administration & dosage/*therapeutic use MH - Clinical Trials as Topic MH - Double-Blind Method MH - Drug Combinations MH - Drug Evaluation MH - Humans MH - Pain, Postoperative/*drug therapy MH - Phenacetin/administration & dosage/*therapeutic use MH - Placebos MH - Promethazine/administration & dosage/*therapeutic use MH - Tooth Extraction EDAT- 1979/06/01 00:00 MHDA- 1979/06/01 00:01 CRDT- 1979/06/01 00:00 PHST- 1979/06/01 00:00 [pubmed] PHST- 1979/06/01 00:01 [medline] PHST- 1979/06/01 00:00 [entrez] AID - 10.1016/0030-4220(79)90272-x [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol. 1979 Jun;47(6):513-4. doi: 10.1016/0030-4220(79)90272-x. PMID- 11210856 OWN - NLM STAT- MEDLINE DCOM- 20010412 LR - 20131121 IS - 0361-7734 (Print) IS - 0361-7734 (Linking) VI - 25 IP - 5 DP - 2000 Sep-Oct TI - Effect of collagen removal on shear bond strength of two single-bottle adhesive systems. PG - 395-400 AB - This study evaluated the effect of collagen removal on the shear bond strength for two single-bottle adhesive systems. The ultrastructure of the dentin after treatments and the dentin-resin interface were examined under SEM. The buccal and lingual surfaces of 80 extracted human third molars were ground to expose dentin. Teeth were randomly assigned to four groups and received the following treatments: Group 1(P&B 2.1), Prime & Bond 2.1 adhesive was applied according to the manufacturer's directions and Restorative Z100 composite resin was bonded to the dentin surface; Group 2 (P&B 2.1/NaOCl), the same procedures were followed as for Group 1 except that the surfaces were treated with 10% sodium hypochlorite (NaOCl) for one minute after acid conditioning; Group 3 (SB), Single Bond (3M) was applied according to the manufacturer's recommendations; Group 4 (SB/NaOCl), the same procedure was followed for Group 2, using Single Bond. The specimens were stored in humidity at 37 degrees C for 24 hours and tested in a shear mode at a crosshead speed of 0.5 mm/minute. The Kruskal-Wallis test and Multiple Comparisons were used for statistical analysis of the data. A one-minute exposure of dentin to 10% NaOCl following acid conditioning resulted in a significant increase of the dentin shear bond strength for Prime & Bond 2.1. The same treatment for Single Bond resulted in a significant reduction in bond strength. Groups 1 and 3 were not statistically different from each other. The presence of a collagen layer resulted in the formation of a hybrid layer and similar values of adhesion for both adhesive systems. The results may suggest that collagen removal improves the bond strength for this acetone-based adhesive system but several such systems would need to be investigated. FAU - Saboia, V P AU - Saboia VP AD - School of Piracicaba-UNICAMP-Av Limeira, 901-Piracicaba-SP-Brazil-13414-018. FAU - Rodrigues, A L AU - Rodrigues AL FAU - Pimenta, L A AU - Pimenta LA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Oper Dent JT - Operative dentistry JID - 7605679 RN - 0 (Composite Resins) RN - 0 (Dentin-Bonding Agents) RN - 0 (Polymethacrylic Acids) RN - 0 (Prime & Bond) RN - 0 (Solvents) RN - 0 (Z100 composite resin) RN - 0 (single bond) RN - 1364PS73AF (Acetone) RN - 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate) RN - 7631-86-9 (Silicon Dioxide) RN - 9007-34-5 (Collagen) RN - C6V6S92N3C (Zirconium) RN - DY38VHM5OD (Sodium Hypochlorite) SB - D MH - Acetone/chemistry MH - Acid Etching, Dental MH - Bisphenol A-Glycidyl Methacrylate/chemistry MH - Collagen/drug effects/*ultrastructure MH - Composite Resins/chemistry MH - *Dental Bonding MH - Dentin/drug effects/*ultrastructure MH - Dentin-Bonding Agents/*chemistry MH - Humans MH - Humidity MH - Microscopy, Electron, Scanning MH - Molar, Third MH - Polymethacrylic Acids/chemistry MH - *Silicon Dioxide MH - Sodium Hypochlorite/pharmacology MH - Solvents/pharmacology MH - Statistics as Topic MH - Stress, Mechanical MH - Surface Properties MH - Temperature MH - *Zirconium EDAT- 2001/02/24 12:00 MHDA- 2001/04/17 10:01 CRDT- 2001/02/24 12:00 PHST- 2001/02/24 12:00 [pubmed] PHST- 2001/04/17 10:01 [medline] PHST- 2001/02/24 12:00 [entrez] PST - ppublish SO - Oper Dent. 2000 Sep-Oct;25(5):395-400. PMID- 359245 OWN - NLM STAT- MEDLINE DCOM- 19781220 LR - 20201209 IS - 0300-7995 (Print) IS - 0300-7995 (Linking) VI - 5 IP - 7 DP - 1978 TI - The analgesic and anti-inflammatory efficacy of diflunisal and codeine after removal of impacted third molars. PG - 525-35 AB - A double-blind, randomized trial was carried out in 90 patients to compare the analgesic and anti-inflammatory efficacy of 500 mg diflunisal twice daily with that of 25 mg codeine phosphate 4-times daily and placebo in relieving pain and swelling after surgical removal of impacted third molars. Diflunisal was found to be superior to codeine and placebo on the first post-operative day, but the difference in efficacy of the drugs had diminished by the third post-operative day. In the diflunisal group of 30 patients, 10 (33%) developed 'dry socket' or alveolitis sicca dolorosa. Only 2 patients in the codeine group and 1 patient in the placebo group developed this very painful condition. The possible explanation of 'dry socket' is discussed. FAU - Petersen, J K AU - Petersen JK LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Curr Med Res Opin JT - Current medical research and opinion JID - 0351014 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Biphenyl Compounds) RN - UX6OWY2V7J (Codeine) SB - IM MH - Adolescent MH - Adult MH - Analgesics/adverse effects/*pharmacology/therapeutic use MH - *Anti-Inflammatory Agents, Non-Steroidal MH - Biphenyl Compounds/adverse effects/*pharmacology/therapeutic use MH - Clinical Trials as Topic MH - Codeine/adverse effects/*pharmacology/therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Molar MH - Pain, Postoperative/drug therapy MH - Sleep/drug effects MH - *Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1978/01/01 00:00 MHDA- 1978/01/01 00:01 CRDT- 1978/01/01 00:00 PHST- 1978/01/01 00:00 [pubmed] PHST- 1978/01/01 00:01 [medline] PHST- 1978/01/01 00:00 [entrez] AID - 10.1185/03007997809108996 [doi] PST - ppublish SO - Curr Med Res Opin. 1978;5(7):525-35. doi: 10.1185/03007997809108996. PMID- 18699786 OWN - NLM STAT- MEDLINE DCOM- 20090113 LR - 20151119 IS - 1365-2591 (Electronic) IS - 0143-2885 (Linking) VI - 41 IP - 10 DP - 2008 Oct TI - Effect of root canal irrigants on cervical dentine permeability to hydrogen peroxide. PG - 821-7 LID - 10.1111/j.1365-2591.2008.01446.x [doi] AB - AIM: To examine the effects of various root canal irrigants on cervical dentine permeability by monitoring the diffusion of hydrogen peroxide (H(2)O(2)). METHODOLOGY: Sixty cervical dentine discs were prepared from human third molar teeth. After removal of enamel and cementum, the outer dentine surface was etched with 17% ethylenediamine tetraacetic acid (EDTA) for 1 min. The dentine discs were randomly assigned to five groups according to the irrigant used: A, saline solution; B, 2.5% sodium hypochlorite solution (NaOCl); C, 5% NaOCl; D, 17% EDTA and 2.5% NaOCl; E, 17% EDTA and 5% NaOCl. After irrigation on the inner dentine surface with the various solutions, the diffusion of 30% H(2)O(2) was evaluated through each disc using a plastic-split chamber. H(2)O(2) was applied to the inner-side chamber, while the outer-side chamber was filled with de-ionised water. After 30 min of application of H(2)O(2), the solution in the outer-side chamber was collected to determine the concentration of H(2)O(2) using a spectrophotometer. RESULTS: The penetration of H(2)O(2) through dentine in group E was significantly highest, followed by groups D, C, B and A respectively (one-way anova, P < 0.05). CONCLUSIONS: Among the irrigants used, 17% EDTA and 5% NaOCl had the greatest effect in increasing dentinal permeability to H(2)O(2). FAU - Surapipongpuntr, P AU - Surapipongpuntr P AD - Restorative Department, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. perayap@nu.ac.th FAU - Duangcharee, W AU - Duangcharee W FAU - Kwangsamai, S AU - Kwangsamai S FAU - Ekka, A AU - Ekka A LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20080811 PL - England TA - Int Endod J JT - International endodontic journal JID - 8004996 RN - 0 (Chelating Agents) RN - 0 (Root Canal Irrigants) RN - 451W47IQ8X (Sodium Chloride) RN - 9G34HU7RV0 (Edetic Acid) RN - BBX060AN9V (Hydrogen Peroxide) RN - DY38VHM5OD (Sodium Hypochlorite) SB - D MH - Acid Etching, Dental MH - Chelating Agents/administration & dosage/pharmacology MH - Dentin/*drug effects/ultrastructure MH - Dentin Permeability/*drug effects MH - Diffusion MH - Diffusion Chambers, Culture MH - Edetic Acid/administration & dosage/pharmacology MH - Humans MH - Hydrogen Peroxide/*pharmacology MH - Microscopy, Electron, Scanning MH - Molar, Third MH - Root Canal Irrigants/administration & dosage/*pharmacology MH - Smear Layer MH - Sodium Chloride MH - Sodium Hypochlorite/administration & dosage/pharmacology MH - Spectrophotometry MH - Time Factors MH - Tooth Cervix/*drug effects MH - Young Adult EDAT- 2008/08/14 09:00 MHDA- 2009/01/14 09:00 CRDT- 2008/08/14 09:00 PHST- 2008/08/14 09:00 [pubmed] PHST- 2009/01/14 09:00 [medline] PHST- 2008/08/14 09:00 [entrez] AID - IEJ1446 [pii] AID - 10.1111/j.1365-2591.2008.01446.x [doi] PST - ppublish SO - Int Endod J. 2008 Oct;41(10):821-7. doi: 10.1111/j.1365-2591.2008.01446.x. Epub 2008 Aug 11. PMID- 1569240 OWN - NLM STAT- MEDLINE DCOM- 19920527 LR - 20190824 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 32 IP - 4 DP - 1992 Apr TI - Comparison of the efficacy and safety of ketorolac and meperidine in the relief of dental pain. PG - 376-84 AB - A single-dose, randomized, double-blind study of parallel design was conducted to determine the analgesic efficacy and safety of ketorolac tromethamine in patients who experience moderate or severe pain after the surgical removal of three or more third molars, one of which was a bony-impacted mandibular molar. Meperidine hydrochloride was used as the control analgesic. In this 8-hour study, assessments were made of pain intensity, pain relief, and overall rating of the medication in 145 patients, each of whom had received an intramuscular injection of 10 mg, 30 mg, or 90 mg of ketorolac, or 50 mg or 100 mg of meperidine. The summed pain intensity and total pain relief scores showed that, at 3 and 8 hours, the effectiveness of 30 mg of ketorolac was similar to that of 90 mg ketorolac and that both of these doses were significantly more efficacious than 10-mg ketorolac, 50-mg meperidine, or 100-mg meperidine. Patients who received 30 mg or 90 mg of ketorolac gave the study medication significantly higher ratings overall than did patients who received 50 mg or 100 mg of meperidine. Significantly fewer patients treated with ketorolac reported adverse events in comparison with those treated with meperidine (17% and 59%, respectively), which suggests that it possesses a better therapeutic index than meperidine. Thus, ketorolac appears to represent an important advance in analgesic therapy. FAU - Fricke, J R Jr AU - Fricke JR Jr AD - Austin Oral Surgical Associates, Texas. FAU - Angelocci, D AU - Angelocci D FAU - Fox, K AU - Fox K FAU - McHugh, D AU - McHugh D FAU - Bynum, L AU - Bynum L FAU - Yee, J P AU - Yee JP LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Analgesics) RN - 023C2WHX2V (Tromethamine) RN - 4EVE5946BQ (Ketorolac Tromethamine) RN - 9E338QE28F (Meperidine) RN - D8K2JPN18B (Tolmetin) SB - IM MH - Analgesics/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Administration Schedule MH - Humans MH - Injections, Intramuscular MH - Ketorolac Tromethamine MH - Meperidine/administration & dosage/adverse effects/*therapeutic use MH - Molar, Third MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tolmetin/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use MH - *Tooth Extraction MH - Tooth, Impacted/surgery MH - Tromethamine/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use EDAT- 1992/04/11 19:15 MHDA- 2001/03/28 10:01 CRDT- 1992/04/11 19:15 PHST- 1992/04/11 19:15 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1992/04/11 19:15 [entrez] AID - 10.1002/j.1552-4604.1992.tb03850.x [doi] PST - ppublish SO - J Clin Pharmacol. 1992 Apr;32(4):376-84. doi: 10.1002/j.1552-4604.1992.tb03850.x. PMID- 15986959 OWN - NLM STAT- MEDLINE DCOM- 20051018 LR - 20131121 IS - 0361-7734 (Print) IS - 0361-7734 (Linking) VI - 30 IP - 3 DP - 2005 May-Jun TI - Effect of solvent type on microtensile bond strength of a total-etch one-bottle adhesive system to moist or dry dentin. PG - 376-81 AB - This study evaluated the effect of organic solvent (acetone or ethanol) on the microtensile bond strengths (MTBS) of an adhesive system applied to dry and moist dentin. Sixteen extracted human third molars were ground to expose a flat occlusal dentin surface and acid etched for 20 seconds (20% phosphoric acid gel, Gluma Etch 20 Gel, Heraeus/Kulzer). After rinsing the acid etchant, an ethanol-based one-bottle adhesive system was applied to the mesial half of the occlusal dentin surface. An acetone-based, one-bottle adhesive system was applied to the distal half of the ground dentin surface. The teeth were randomly assigned to groups. In Group 1, the etched dentin was thoroughly air dried and an ethanol-based one-bottle adhesive system was applied (Gluma Comfort Bond, Heraeus/Kulzer) (GCB). In Group 2, the etched dentin was thoroughly air dried and an acetone-based one-bottle adhesive system was applied (Gluma One Bond, Heraeus/Kulzer)(GOB). In Group 3, excess moisture was removed after acid etching, leaving a moist dentin surface and a one-bottle ethanol-based adhesive was applied (Gluma Comfort Bond). In Group 4, excess moisture was removed after acid etching, leaving a moist dentin surface and an acetone-based adhesive was applied (Gluma One Bond). A hybrid resin composite (Venus, Heraeus/Kulzer) was applied to the bonded surface in four 1-mm increments and light cured according to manufacturer's directions. The specimens were then sectioned with a slow-speed diamond saw in two perpendicular directions to obtain sticks with a cross-section of 0.5 +/- 0.05 mm2. The microtensile bond strength (MTBS) test was performed with a Bencor device in an Instron machine at a crosshead speed of 0.5 mm/minute. The data were subjected to a two-way ANOVA and Scheffé Post hoc test (p < 0.05). The experimental MTBS measured for dry dentin were Group 1 = 37.0 +/- 10.6 and Group 2 = 34.7 +/- 9.0 in MPa (mean +/- SD); and on moist dentin, Group 3 = 50.7 +/- 11.0 and Group 4 = 38.5 +/- 10.5 in MPa (mean +/- SD). The ethanol based adhesives resulted in higher MTBS than acetone-based adhesive (p < 0.008) and bonding to moist dentin resulted in higher MTBS (p < 0.001). GCB applied on moist dentin resulted in statistically higher bond strengths than the other groups. The highest MTBS were achieved with the use of an ethanol-based adhesive to moist dentin. FAU - Cardoso, Paula de Carvalho AU - Cardoso Pde C AD - Department of Operative Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil. FAU - Lopes, Guilherme Carpena AU - Lopes GC FAU - Vieira, Luiz Clovis Cardoso AU - Vieira LC FAU - Baratieri, Luiz Narciso AU - Baratieri LN LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oper Dent JT - Operative dentistry JID - 7605679 RN - 0 (Adhesives) RN - 0 (Composite Resins) RN - 0 (Dentin-Bonding Agents) RN - 0 (Gluma Comfort Bond) RN - 0 (Gluma One Bond) RN - 0 (Resin Cements) RN - 0 (Solvents) RN - 0 (Venus (composite resin)) RN - 059QF0KO0R (Water) RN - 1364PS73AF (Acetone) RN - 3K9958V90M (Ethanol) SB - D MH - Acetone/pharmacology MH - Adhesives/chemistry/*pharmacology MH - Analysis of Variance MH - Composite Resins/chemistry/pharmacology MH - Dental Bonding/methods MH - Dentin/*drug effects MH - Dentin-Bonding Agents/chemistry/*pharmacology MH - Ethanol/pharmacology MH - Humans MH - Molar, Third MH - Resin Cements/chemistry/*pharmacology MH - Solvents/*pharmacology MH - Tensile Strength/drug effects MH - Water/*adverse effects EDAT- 2005/07/01 09:00 MHDA- 2005/10/19 09:00 CRDT- 2005/07/01 09:00 PHST- 2005/07/01 09:00 [pubmed] PHST- 2005/10/19 09:00 [medline] PHST- 2005/07/01 09:00 [entrez] PST - ppublish SO - Oper Dent. 2005 May-Jun;30(3):376-81. PMID- 10613619 OWN - NLM STAT- MEDLINE DCOM- 20000104 LR - 20201208 IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 66 IP - 6 DP - 1999 Dec TI - Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study. PG - 625-35 AB - In a randomized double-blind study, 120 patients with moderate to strong pain after surgical removal of wisdom teeth were given the following in single oral doses: 100-mg enteric-coated diclofenac tablets; 1 g acetaminophen (INN, paracetamol); 1 g acetaminophen plus 60 mg codeine; 100-mg enteric-coated diclofenac tablets plus 1 g acetaminophen; or 100-mg enteric-coated diclofenac tablets plus 1 g acetaminophen plus 60 mg codeine. Patients recorded pain intensity and pain relief for 8 hours. Upside assay sensitivity was confirmed because acetaminophen plus codeine was superior to acetaminophen. Diclofenac plus acetaminophen with and without codeine had superior analgesic effect compared with diclofenac, acetaminophen, or acetaminophen plus codeine. Addition of 60 mg codeine increased the degree of side effects. These results support the clinical practice of combining diclofenac with acetaminophen for acute pain. Of clinical importance are superior and prolonged analgesia and fewer side effects after enteric-coated diclofenac tablets plus acetaminophen compared with acetaminophen plus codeine. FAU - Breivik, E K AU - Breivik EK AD - Department of Oral Surgery and Oral Medicine, Institute for Basic Medical Sciences, University of Oslo, Norway. FAU - Barkvoll, P AU - Barkvoll P FAU - Skovlund, E AU - Skovlund E LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Drug Combinations) RN - 0 (Tablets, Enteric-Coated) RN - 144O8QL0L1 (Diclofenac) RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - AIM SB - IM MH - Acetaminophen/administration & dosage/adverse effects/*therapeutic use MH - Administration, Oral MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/adverse effects/*therapeutic use MH - Analgesics, Opioid/administration & dosage/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects/*therapeutic use MH - Codeine/administration & dosage/adverse effects/*therapeutic use MH - Diclofenac/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Drug Therapy, Combination MH - Humans MH - Linear Models MH - Molar, Third/*surgery MH - Pain Measurement MH - Pain, Postoperative/*drug therapy/etiology MH - Tablets, Enteric-Coated MH - Tooth Extraction/*adverse effects MH - Treatment Outcome EDAT- 1999/12/29 00:00 MHDA- 1999/12/29 00:01 CRDT- 1999/12/29 00:00 PHST- 1999/12/29 00:00 [pubmed] PHST- 1999/12/29 00:01 [medline] PHST- 1999/12/29 00:00 [entrez] AID - S0009-9236(99)00180-0 [pii] AID - 10.1053/cp.1999.v66.103629001 [doi] PST - ppublish SO - Clin Pharmacol Ther. 1999 Dec;66(6):625-35. doi: 10.1053/cp.1999.v66.103629001. PMID- 12152003 OWN - NLM STAT- MEDLINE DCOM- 20020820 LR - 20151119 IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 72 IP - 1 DP - 2002 Jul TI - In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model. PG - 44-9 AB - OBJECTIVE: Prostanoids formed by cyclooxygenase play an important role in pain and the induction of inflammation. It is generally believed that COX-1 is constitutively expressed, whereas COX-2 is primarily inducible during inflammation. This study examined the in vivo selectivity of celecoxib, a COX-2 inhibitor, and evaluated whether estimates of selectivity that are based on in vitro and ex vivo analyses are reliable indicators of in vivo selectivity. METHODS: Subjects (103 outpatients undergoing surgical removal of two impacted mandibular third molars) received either 200 mg celecoxib, 600 mg ibuprofen, or placebo 8 hours before surgery and a second dose 1 hour before surgery. After surgery, microdialysis probes were placed in the surgical sites for collection of inflammatory transudate. Samples were collected every 20 minutes and pain intensity was estimated concurrently with a visual analog scale and a categorical rating scale for up to 4 hours after surgery. RESULTS: A significant analgesic effect (P <.01, compared with placebo) was shown for both drugs, with the efficacy of celecoxib being intermediate between ibuprofen and placebo. A similar relationship was observed for the suppression of prostaglandin E(2) (a product of both isoforms) at time points consistent with COX-2 expression (P <.001). Ibuprofen consistently suppressed thromboxane B(2) (a product of COX-1) levels at all time points (P <.05), whereas the effect of celecoxib did not differ from that of placebo. CONCLUSIONS: The suppression of products of COX-2 coincident with pain suppression and the absence of COX-1 inhibition suggest that celecoxib is a relatively selective COX-2 inhibitor in vivo. FAU - Khan, Asma A AU - Khan AA AD - Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda MD 20892-1258, USA. FAU - Brahim, Jaime S AU - Brahim JS FAU - Rowan, Janet S AU - Rowan JS FAU - Dionne, Raymond A AU - Dionne RA LA - eng GR - T32DE07309/DE/NIDCR NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Cyclooxygenase 2 Inhibitors) RN - 0 (Cyclooxygenase Inhibitors) RN - 0 (Isoenzymes) RN - 0 (Membrane Proteins) RN - 0 (Pyrazoles) RN - 0 (Sulfonamides) RN - 54397-85-2 (Thromboxane B2) RN - EC 1.14.99.1 (Cyclooxygenase 2) RN - EC 1.14.99.1 (PTGS2 protein, human) RN - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases) RN - JCX84Q7J1L (Celecoxib) RN - K7Q1JQR04M (Dinoprostone) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - IM MH - Adult MH - Celecoxib MH - Cyclooxygenase 2 MH - Cyclooxygenase 2 Inhibitors MH - Cyclooxygenase Inhibitors/*therapeutic use MH - Dinoprostone/metabolism MH - Double-Blind Method MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Ibuprofen/therapeutic use MH - Isoenzymes/*metabolism MH - Male MH - Membrane Proteins MH - Microdialysis MH - Molar, Third MH - *Oral Surgical Procedures MH - Pain Measurement/drug effects MH - Pain, Postoperative/*drug therapy MH - Prostaglandin-Endoperoxide Synthases/*metabolism MH - Pyrazoles MH - Substrate Specificity MH - Sulfonamides/*therapeutic use MH - Thromboxane B2/metabolism MH - Tooth Extraction EDAT- 2002/08/02 10:00 MHDA- 2002/08/21 10:01 CRDT- 2002/08/02 10:00 PHST- 2002/08/02 10:00 [pubmed] PHST- 2002/08/21 10:01 [medline] PHST- 2002/08/02 10:00 [entrez] AID - S0009923602000218 [pii] AID - 10.1067/mcp.2002.125560 [doi] PST - ppublish SO - Clin Pharmacol Ther. 2002 Jul;72(1):44-9. doi: 10.1067/mcp.2002.125560. PMID- 1097978 OWN - NLM STAT- MEDLINE DCOM- 19751108 LR - 20151119 IS - 0029-8441 (Print) IS - 0029-8441 (Linking) VI - 26 IP - 2 DP - 1975 TI - Complications after removal of mandibular third molars with special reference to local anaesthetics with different vasoactive properties. PG - 149-64 AB - Nhe symptoms after surgical removal of 379 mandibular wisdom teeth when Xylocain-Exadrin 2% and Citanest-Octopressin 3% were used, were evaluated according to a three grade scale. The severity of the symptoms, which were mild and normal in 53% and severe in 47%, did not demonstrably vary with the type of anaesthetic agent used. The symptoms were, on the average, more severe among the women than among the men. The symptoms were correlated with the duration of the operation, which was most obvious in the men. For the men the frequency of symptoms also increased with age. In the men there was also a tendency to a correlation between dry socket and long duration of operation. It thus appeared as if only the men reacted in the way expected from a biologic point of view. The investigation also showed that Xylocain-Exadrin had a better anaesthetic and ischemic effect. FAU - Keskitalo, E AU - Keskitalo E FAU - Persson, G AU - Persson G LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Sweden TA - Odontol Revy JT - Odontologisk revy JID - 0404451 RN - 0 (Analgesics) RN - 046O35D44R (Prilocaine) RN - 98PI200987 (Lidocaine) SB - D SB - IM MH - Adolescent MH - Adult MH - Alveolar Process/blood supply MH - Analgesics/metabolism MH - Anesthesia, Dental/*adverse effects MH - Clinical Trials as Topic MH - Deglutition Disorders/etiology MH - Dental Caries/*epidemiology MH - Dry Socket/etiology MH - Edema/etiology MH - Female MH - Humans MH - Ischemia/etiology MH - Lidocaine/*adverse effects MH - Male MH - Mandibular Nerve MH - Middle Aged MH - Molar/*surgery MH - Mouth/physiopathology MH - Nerve Block MH - Oral Hemorrhage/*etiology MH - Pain/etiology MH - Prilocaine/*adverse effects MH - Sex Factors MH - Sleep Wake Disorders/etiology MH - Surveys and Questionnaires MH - *Tooth Extraction EDAT- 1975/01/01 00:00 MHDA- 1975/01/01 00:01 CRDT- 1975/01/01 00:00 PHST- 1975/01/01 00:00 [pubmed] PHST- 1975/01/01 00:01 [medline] PHST- 1975/01/01 00:00 [entrez] PST - ppublish SO - Odontol Revy. 1975;26(2):149-64. PMID- 33473242 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210122 IS - 1013-9052 (Print) IS - 1658-3558 (Electronic) IS - 1013-9052 (Linking) VI - 33 IP - 1 DP - 2021 Jan TI - Efficacy of Commiphora myrrh mouthwash on early wound healing after tooth extraction: A randomized controlled trial. PG - 44-54 LID - 10.1016/j.sdentj.2019.11.011 [doi] AB - BACKGROUND: The early period after tooth extraction is a critical period for wound healing. Wound healing after tooth extraction is considered secondary intention healing. It passes through several stages in the following order: hemostasis, inflammatory phase, proliferative phase, and finally the remodeling phase.Wounds usually heal normally unless there is interference by local or systemic factors. In certain circumstances, early wound healing can be enhanced by several interventions such as antibiotics, mouthwashes, or topical medications. Myrrh has been used as a topical medication for promoting wound healing after tooth extraction. The purpose of this study was to assess the wound healing effect of myrrh mouthwash during the early post-extraction period. METHODS: We enrolled 40 healthy adult patients in this study (20: study group and 20: control group). All the activities performed for each group were double-blinded. All the participants underwent dental extraction under local anesthesia using standard protocol. Next, the study group used Commiphora molmol (myrrh) extract as a mouthwash while the control group used normal saline mouthwash. The participants used the mouthwashes twice a day for 7 days starting from the first post-extraction day. Clinical examination data were recorded and analyzed using the Mann Whitney Wilcoxon test. RESULTS: There was a statistically significant between-group difference in postoperative surgical-site edema, tenderness, and socket size, with the test group showing greater improvements. CONCLUSIONS: Myrrh mouthwash has an enhancement effect on wound healing during the early period after tooth extraction. CI - © 2019 King Saud University. FAU - Eid, Raniah Abdullah Al AU - Eid RAA AD - Faculty Member at the Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20191216 TA - Saudi Dent J JT - The Saudi dental journal JID - 9313603 PMC - PMC7801243 OTO - NOTNLM OT - IRB, Institutional Review Board OT - ISRCTN, International Standard Randomized Controlled Trial Number OT - Myrrh OT - Tooth extraction OT - Wound healing COIS- None. EDAT- 2021/01/22 06:00 MHDA- 2021/01/22 06:01 CRDT- 2021/01/21 05:34 PHST- 2019/09/11 00:00 [received] PHST- 2019/11/24 00:00 [revised] PHST- 2019/11/26 00:00 [accepted] PHST- 2021/01/21 05:34 [entrez] PHST- 2021/01/22 06:00 [pubmed] PHST- 2021/01/22 06:01 [medline] AID - S1013-9052(19)30918-6 [pii] AID - 10.1016/j.sdentj.2019.11.011 [doi] PST - ppublish SO - Saudi Dent J. 2021 Jan;33(1):44-54. doi: 10.1016/j.sdentj.2019.11.011. Epub 2019 Dec 16. PMID- 12035957 OWN - NLM STAT- MEDLINE DCOM- 20020813 LR - 20190901 IS - 0045-0421 (Print) IS - 0045-0421 (Linking) VI - 47 IP - 1 DP - 2002 Mar TI - Intra-muscular ketorolac administered as a supplemental analgesic for removal of impacted third molar teeth: a prospective study. PG - 41-4 AB - BACKGROUND: Post-operative pain follows dentalveolar oral surgery. Ketorolac is a potent non-steroidal analgesic with moderate anti-inflammatory effects. The purpose of this study was to test whether a single supplementary dose of ketorolac reduced post-operative pain experienced by patients having third molar teeth removed. METHODS: A prospective double-blind trial utilizing 30mg of ketorolac and a standard anaesthetic and surgical technique was performed on 65 female patients having impacted third molar teeth removed. Assessment was made by means of a patient questionnaire and visual analogue pain scales and subjected to statistical analysis. RESULTS: There was a statistically significant difference confirming improved pain relief for patients receiving ketorolac 30mg at the early postoperative stage (two hours) but at later time intervals (four and six hours) there was no significant difference. Seventy two per cent of patients found ketorolac to be a satisfactory analgesic for postoperative pain. There were minimal side effects. CONCLUSION: A single supplemental dose of ketorolac 30mg provides improved pain relief in the immediate post-operative phase following the removal of third molar teeth. Oral ketorolac can be recommended as a oral analgesic for post-operative pain, with minimal side effects. FAU - Wright, G AU - Wright G AD - The University of Melbourne, Victoria. FAU - Smith, A AU - Smith A LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Australia TA - Aust Dent J JT - Australian dental journal JID - 0370612 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - YZI5105V0L (Ketorolac) SB - D SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Injections, Intramuscular MH - Ketorolac/*administration & dosage MH - Pain Measurement MH - Pain, Postoperative/*drug therapy/etiology MH - Prospective Studies MH - Surveys and Questionnaires MH - Tooth Extraction/*adverse effects EDAT- 2002/05/31 10:00 MHDA- 2002/08/14 10:01 CRDT- 2002/05/31 10:00 PHST- 2002/05/31 10:00 [pubmed] PHST- 2002/08/14 10:01 [medline] PHST- 2002/05/31 10:00 [entrez] AID - 10.1111/j.1834-7819.2002.tb00302.x [doi] PST - ppublish SO - Aust Dent J. 2002 Mar;47(1):41-4. doi: 10.1111/j.1834-7819.2002.tb00302.x. PMID- 30175188 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2345-6485 (Print) IS - 2345-6418 (Electronic) IS - 2345-6418 (Linking) VI - 19 IP - 3 DP - 2018 Sep TI - Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial. PG - 189-196 AB - STATEMENT OF THE PROBLEM: Extraction of the impacted third molar is often associated with severe postoperative pains, management of which are a big challenge. Lamotrigine is a new antiepileptic drug with pre-emptive analgesic properties, which is hypothesized to alleviate postoperative pain. PURPOSE: This study aimed to evaluate the efficacy of pre-operative administration of single oral 200 mg lamotrigine in reducing the postoperative pain of impacted third molar surgery. MATERIALS AND METHOD: In this randomized controlled trial, 100 adult patients were divided into two groups (n= 50) to receive either 200 mg oral lamotrigine or placebo 1 hour before the removal of impacted third molar. The patients were monitored for 4 hours in the recovery room and pain intensity was measured through visual analogue scale (VAS) for the next 12 hours at 30-minute intervals. The time and number of rescue analgesics used in 12 hours was also recorded. RESULTS: Two groups were not statistically significantly different regarding the severity of postoperative pain. (p= 0.512). CONCLUSION: Accordingly, pre-emptive administration of lamotrigine was not effective in diminishing the postoperative acute pain of impacted third molar extraction. FAU - Modanloo, Hamed AU - Modanloo H AD - Postgraduate Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Eftekharian, Hamidreza AU - Eftekharian H AD - Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Arabiun, Hamidreza AU - Arabiun H AD - Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. LA - eng PT - Journal Article TA - J Dent (Shiraz) JT - Journal of dentistry (Shiraz, Iran) JID - 101615440 PMC - PMC6092458 OTO - NOTNLM OT - Pain Management OT - Third Molar OT - Lamotrigine EDAT- 2018/09/04 06:00 MHDA- 2018/09/04 06:01 CRDT- 2018/09/04 06:00 PHST- 2018/09/04 06:00 [entrez] PHST- 2018/09/04 06:00 [pubmed] PHST- 2018/09/04 06:01 [medline] AID - JDS-19-3 [pii] PST - ppublish SO - J Dent (Shiraz). 2018 Sep;19(3):189-196. PMID- 9511622 OWN - NLM STAT- MEDLINE DCOM- 19980812 LR - 20201209 IS - 0011-8516 (Print) IS - 0011-8516 (Linking) VI - 47 IP - 9 DP - 1992 Sep TI - Comparison of the safety and efficacy of a combination analgesic Myprodol and Ponstan in the treatment of dental pain. PG - 403-6 AB - A comparison of the efficacy of Myprodol, a combination analgesic (Ibuprofen, Paracetamol and Codeine phosphate) and Ponstan (Mefenamic acid) was undertaken in a randomised double blind trial of 52 patients who underwent surgical removal of impacted or unerupted teeth. Pain scores were measured for patients pre- and post operatively by means of a visual analogue scale and data was analysed using the BMPD package on the ISM main frame computer at the Medical Research Council. The results indicated that although Myprodol and Ponstan were equally adequate and well tolerated in the control of post operative dental pain, Myprodol exceeded Ponstan in duration of analgesia and in the degree of pain intensity control experienced by the patient. FAU - Lownie, J F AU - Lownie JF AD - Department of Surgery, University of the Witwatersrand, Johannesburg. FAU - Lownie, M A AU - Lownie MA FAU - Reinach, S G AU - Reinach SG LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - South Africa TA - J Dent Assoc S Afr JT - The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika JID - 7505600 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Drug Combinations) RN - 0 (Myprodol) RN - 362O9ITL9D (Acetaminophen) RN - 367589PJ2C (Mefenamic Acid) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - D MH - Acetaminophen/adverse effects/*therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/*therapeutic use MH - Analgesics, Opioid/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Codeine/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/adverse effects/*therapeutic use MH - Male MH - Mefenamic Acid/adverse effects/*therapeutic use MH - Molar, Third MH - Pain, Postoperative/*drug therapy/etiology MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/complications/surgery MH - Tooth, Unerupted/complications/surgery EDAT- 1992/09/01 00:00 MHDA- 1998/03/25 00:01 CRDT- 1992/09/01 00:00 PHST- 1992/09/01 00:00 [pubmed] PHST- 1998/03/25 00:01 [medline] PHST- 1992/09/01 00:00 [entrez] PST - ppublish SO - J Dent Assoc S Afr. 1992 Sep;47(9):403-6. PMID- 28879306 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2383-9309 (Print) IS - 2383-9317 (Electronic) IS - 2383-9309 (Linking) VI - 16 IP - 2 DP - 2016 Jun TI - Pain and quality of life related to suture removal after 3 or 7 days at the extraction sites of impacted lower third molars. PG - 131-136 LID - 10.17245/jdapm.2016.16.2.131 [doi] AB - BACKGROUND: This study aimed to evaluate the patient's pain and quality of life after suture removal at either 3 or 7 days following the bilateral surgical extraction of impacted lower third molars. METHODS: This study was a prospective, randomized controlled clinical trial carried out in 30 patients, who acted as their own control. Each patient required the bilaterally impacted mandibular third molars to be extracted. The impacted teeth were removed and the wound margins were approximated and sutured with black braided silk. The suture material was removed on day 3 on one side and on day 7 on the other. Each participant was asked to complete a questionnaire after the removal of the suture material on each designated day. RESULTS: Regarding overall clinical symptoms, the mean VAS scores of male and female participants on day 3 were not significantly different from those on day 7. A significant difference was found in female participants, in that overall daily activity was better on day 7. There were significant differences in the ability to smile and laugh in both sexes and the ability to chew in the male participants was better on day 7. CONCLUSIONS: There were no significant differences in the patient's pain and quality of life between suture removal on day 3 or on day 7 following surgery to remove impacted lower third molars. FAU - Rodanant, Pirasut AU - Rodanant P AD - Department of Advanced General Dentistry, Faculty of Dentistry Mahidol University, Bangkok, Thailand. FAU - Wattanajitseree, Kannika AU - Wattanajitseree K AD - Department of Advanced General Dentistry, Faculty of Dentistry Mahidol University, Bangkok, Thailand. FAU - Shrestha, Binit AU - Shrestha B AD - Maxillofacial Prosthetic Unit, Department of Oral and Maxillofacial Prosthodontic, Faculty of Dentistry Mahidol University, Bangkok, Thailand. FAU - Wongsirichat, Natthamet AU - Wongsirichat N AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20160630 TA - J Dent Anesth Pain Med JT - Journal of dental anesthesia and pain medicine JID - 101690691 PMC - PMC5564082 OTO - NOTNLM OT - Pain OT - Patient satisfaction OT - Quality of life OT - Suture technique OT - Third molar OT - Trismus EDAT- 2016/06/01 00:00 MHDA- 2016/06/01 00:01 CRDT- 2017/09/08 06:00 PHST- 2016/06/05 00:00 [received] PHST- 2016/06/25 00:00 [revised] PHST- 2016/06/27 00:00 [accepted] PHST- 2017/09/08 06:00 [entrez] PHST- 2016/06/01 00:00 [pubmed] PHST- 2016/06/01 00:01 [medline] AID - 10.17245/jdapm.2016.16.2.131 [doi] PST - ppublish SO - J Dent Anesth Pain Med. 2016 Jun;16(2):131-136. doi: 10.17245/jdapm.2016.16.2.131. Epub 2016 Jun 30. PMID- 26718872 OWN - NLM STAT- MEDLINE DCOM- 20160428 LR - 20200814 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 2015 IP - 12 DP - 2015 Dec 31 TI - Preformed crowns for decayed primary molar teeth. PG - CD005512 LID - 10.1002/14651858.CD005512.pub3 [doi] LID - CD005512 AB - BACKGROUND: Crowns for primary molars are preformed and come in a variety of sizes and materials to be placed over decayed or developmentally defective teeth. They can be made completely of stainless steel (know as 'preformed metal crowns' or PMCs), or to give better aesthetics, may be made of stainless steel with a white veneer cover or made wholly of a white ceramic material. In most cases, teeth are trimmed for the crowns to be fitted conventionally using a local anaesthetic. However, in the case of the Hall Technique, PMCs are pushed over the tooth with no local anaesthetic, carious tissue removal or tooth preparation. Crowns are recommended for restoring primary molar teeth that have had a pulp treatment, are very decayed or are badly broken down. However, few dental practitioners use them in clinical practice. This review updates the original review published in 2007. OBJECTIVES: Primary objectiveTo evaluate the clinical effectiveness and safety of all types of preformed crowns for restoring primary teeth compared with conventional filling materials (such as amalgam, composite, glass ionomer, resin modified glass ionomer and compomers), other types of crowns or methods of crown placement, non-restorative caries treatment or no treatment. Secondary objectiveTo explore whether the extent of decay has an effect on the clinical outcome of primary teeth restored with all types of preformed crowns compared with those restored with conventional filling materials. SEARCH METHODS: We searched the following electronic databases: Cochrane Oral Health Group Trials Register (to 21 January 2015), Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library, 2014, Issue 12), MEDLINE via Ovid (1946 to 21 January 2015) and EMBASE via Ovid (1980 to 21 January 2015). We searched the US National Institutes of Health Trials Register (http://clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform for ongoing trials and Open Grey for grey literature (to 21 January 2015). No restrictions were placed on the language or date of publication when searching the databases. SELECTION CRITERIA: Randomised controlled trials (RCTs) that assessed the effectiveness of crowns compared with fillings, other types of crowns, non-restorative approaches or no treatment in children with untreated tooth decay in one or more primary molar teeth. We would also have included trials comparing different methods of fitting crowns.For trials to be considered for this review, the success or failure of the interventions and other clinical outcomes had to be reported at least six months after intervention (with the exception of 'pain/discomfort during treatment and immediately postoperatively'). DATA COLLECTION AND ANALYSIS: Two review authors independently assessed the title and abstracts for each article from the search results. and independently assessed the full text for each potentially relevant study. At least two authors assessed risk of bias and extracted data using a piloted data extraction form. MAIN RESULTS: We included five studies that evaluated three comparisons. Four studies compared crowns with fillings; two of them compared conventional PMCs with open sandwich restorations, and two compared PMCs fitted using the Hall Technique with fillings. One of these studies included a third arm, which allowed the comparison of PMCs (fitted using the Hall Technique) versus non-restorative caries treatment. In the two studies using crowns fitted using the conventional method, all teeth had undergone pulpotomy prior to the crown being placed. The final study compared two different types of crowns: PMCs versus aesthetic stainless steel crowns with white veneers. No RCT evidence was found that compared different methods of fitting preformed metal crowns (i.e. Hall Technique versus conventional technique).We considered outcomes reported at the dental appointment or within 24 hours of it, and in the short term (less than 12 months) or long term (12 months or more). Some of our outcomes of interest were not measured in the studies: time to restoration failure or retreatment, patient satisfaction and costs. Crowns versus fillingsAll studies in this comparison used PMCs. One study reported outcomes in the short term and found no reports of major failure or pain in either group. There was moderate quality evidence that the risk of major failure was lower in the crowns group in the long term (risk ratio (RR) 0.18, 95% confidence interval (CI) 0.06 to 0.56; 346 teeth in three studies, one conventional and two using Hall Technique). Similarly, there was moderate quality evidence that the risk of pain was lower in the long term for the crown group (RR 0.15, 95% CI 0.04 to 0.67; 312 teeth in two studies).Discomfort associated with the procedure was lower for crowns fitted using the Hall Technique than for fillings (RR 0.56, 95% CI 0.36 to 0.87; 381 teeth) (moderate quality evidence).It is uncertain whether there is a clinically important difference in the risk of gingival bleeding when using crowns rather than fillings, either in the short term (RR 1.69, 95% CI 0.61 to 4.66; 226 teeth) or long term (RR 1.74, 95% CI 0.99 to 3.06; 195 teeth, two studies using PMCs with conventional technique at 12 months) (low quality evidence). Crowns versus non-restorative caries treatmentOnly one study compared PMCs (fitted with the Hall Technique) with non-restorative caries treatment; the evidence quality was very low and we are therefore we are uncertain about the estimates. Metal crowns versus aesthetic crownsOne split-mouth study (11 participants) compared PMCs versus aesthetic crowns (stainless steel with white veneers). It provided very low quality evidence so no conclusions could be drawn. AUTHORS' CONCLUSIONS: Crowns placed on primary molar teeth with carious lesions, or following pulp treatment, are likely to reduce the risk of major failure or pain in the long term compared to fillings. Crowns fitted using the Hall Technique may reduce discomfort at the time of treatment compared to fillings. The amount and quality of evidence for crowns compared to non-restorative caries, and for metal compared with aesthetic crowns, is very low. There are no RCTs comparing crowns fitted conventionally versus using the Hall Technique. FAU - Innes, Nicola P T AU - Innes NP AD - Dundee Dental School, University of Dundee, Park Place, Dundee, Tayside, UK, DD1 4HN. FAU - Ricketts, David AU - Ricketts D FAU - Chong, Lee Yee AU - Chong LY FAU - Keightley, Alexander J AU - Keightley AJ FAU - Lamont, Thomas AU - Lamont T FAU - Santamaria, Ruth M AU - Santamaria RM LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20151231 TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2007;(1):CD005512. PMID: 17253559 MH - Child MH - Child, Preschool MH - *Crowns/adverse effects MH - Dental Care for Children/adverse effects/*methods MH - Dental Caries/*rehabilitation MH - Dental Restoration Failure MH - Dental Restoration, Permanent/methods MH - Female MH - Humans MH - Male MH - Molar MH - Randomized Controlled Trials as Topic MH - *Tooth, Deciduous PMC - PMC7387869 COIS- ORIGINAL 2007 REVIEW: Whilst there is no conflict of interest with regard to one of the review authors (David Ricketts (DR)), two of the review authors (Nicola Innes (NI) and Dafydd Evans (DE)) received partial sponsorship in 2000, from 3M/ESPE, for a clinical trial investigating the use of preformed metal crowns to seal carious tissues into primary molar teeth using a different technique (the Hall Technique) to that investigated in this review. These authors have not taken part in the decision to include the study into the review or assessment of risk of bias of the study. 2015 UPDATE: Nicola PT Innes: received partial sponsorship in 2000 from 3M/ESPE for a clinical trial investigating the use of preformed metal crowns to seal carious tissues into primary molar teeth using the Hall Technique. She was an author on another included study. She did not take part in the decision to include these studies (Innes 2011; Santamaria 2014), nor did she conduct the risk of bias assessment or data extraction for them.
 David Ricketts: none known
 Lee Yee Chong: none known
 Alexander J Keightley: none known
 Thomas Lamont: none known
 Ruth Santamaria: was an author on one of the included studies (Santamaria 2014), but did not have any involvement in study selection, risk of bias assessment or data extraction for that study. EDAT- 2016/01/01 06:00 MHDA- 2016/04/29 06:00 CRDT- 2016/01/01 06:00 PHST- 2016/01/01 06:00 [entrez] PHST- 2016/01/01 06:00 [pubmed] PHST- 2016/04/29 06:00 [medline] AID - CD005512.pub3 [pii] AID - 10.1002/14651858.CD005512.pub3 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2015 Dec 31;2015(12):CD005512. doi: 10.1002/14651858.CD005512.pub3. PMID- 15922815 OWN - NLM STAT- MEDLINE DCOM- 20050720 LR - 20131121 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 27 IP - 4 DP - 2005 Apr TI - Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blind, placebo-controlled, single-dose, parallel-group study in a dental pain model. PG - 418-29 AB - BACKGROUND: Combination therapy has been widely used for the clinical management of acute pain. By combining 2 drugs with different mechanisms of action, such therapy provides additive analgesic effects while reducing the risk for adverse effects. OBJECTIVE: This study compared the efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg with those of oxycodone 5 mg/acetaminophen 325 mg, hydrocodone 7.5 mg/acetaminophen 500 mg, and placebo in a dental pain model. METHODS: This was a multicenter, randomized, double-blind, placebo- and active-controlled, parallel-group, single-dose study in patients experiencing moderate to severe pain after surgical removal of > or = 2 ipsilateral impacted third molars. Patients were randomly assigned to receive oxycodone 5 mg/ibuprofen 400 mg, oxycodone 5 mg/acetaminophen 325 mg, hydrocodone 7.5 mg/acetaminophen 500 mg, or placebo. The primary outcome measures were total pain relief through 6 hours after dosing (TOTPAR6), sum of pain intensity differences through 6 hours (SPID6), and adverse events. Secondary efficacy measures included SPID3 and TOTPAR3, peak pain relief, peak pain intensity difference, time to onset of pain relief, time to use of rescue medication, proportion of patients reporting pain half gone, and the patient's global evaluation. RESULTS: Two hundred forty-nine patients (43.5% male; 87.5% white; mean age, 19.1 years; mean body weight, 153.6 pounds) were randomized to treatment as follows: 62 to oxycodone 5 mg/ibuprofen 400 mg, 61 to oxycodone 5 mg/acetaminophen 325 mg, 63 to hydrocodone 7.5 mg/acetaminophen 500 mg, and 63 to placebo. Oxycodone 5 mg/ibuprofen 400 mg provided significantly greater analgesia compared with oxycodone 5 mg/acetaminophen 325 mg, hydrocodone 7.5 mg/acetaminophen 500 mg, and placebo (mean [SD] TOTPAR6, 14.98 [5.37], 9.53 [6.77], 8.36 [6.68], and 5.05 [6.49], respectively; P < 0.001, oxycodone 5 mg/ibuprofen 400 mg vs all other treatments). SPID6 values also differed significantly for oxycodone 5 mg/ibuprofen 400 mg compared with all other treatments (mean: 7.78 [4.11], 3.58 [4.64], 3.32 [4.73], and 0.69 [4.85]; P < 0.001). Oxycodone 5 mg/ibuprofen 400 mg was significantly more effective compared with the other treatments on all secondary end points (P < 0.001, all variables except peak PID vs oxycodone 5 mg/acetaminophen 325 mg [P = 0.006]), with the exception of the time to onset of analgesia. The lowest frequency of nausea and vomiting occurred in the groups that received oxycodone 5 mg/ibuprofen 400 mg (6.5% and 3.2%, respectively) and placebo (3.2% and 1.6%). Rates of nausea and vomiting were significantly lower with oxycodone 5 mg/ibuprofen 400 mg compared with oxycodone 5 mg/acetaminophen 325 mg (P = 0.011 and P = 0.009, respectively) but not with hydrocodone 7.5 mg/acetaminophen 500 mg. CONCLUSIONS: In this study in patients with moderate to severe pain after surgery to remove impacted third molars, oxycodone 5 mg/ibuprofen 400 mg provided significantly better analgesia throughout the 6-hour study compared with the other opioid/nonopioid combinations tested, and was associated with fewer adverse events. FAU - Litkowski, Leonard J AU - Litkowski LJ AD - Center for Clinical Studies, Dental School, University of Maryland, Baltimore, Maryland 21201, USA. ljl001@dental.maryland.edu FAU - Christensen, Steven E AU - Christensen SE FAU - Adamson, Dennis N AU - Adamson DN FAU - Van Dyke, Thomas AU - Van Dyke T FAU - Han, Seung-Ho AU - Han SH FAU - Newman, Kenneth B AU - Newman KB LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - 6YKS4Y3WQ7 (Hydrocodone) RN - CD35PMG570 (Oxycodone) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Acetaminophen/administration & dosage/adverse effects/*therapeutic use MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage/adverse effects/*therapeutic use MH - Analgesics, Opioid/administration & dosage/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects/*therapeutic use MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Hydrocodone/administration & dosage/adverse effects/*therapeutic use MH - Ibuprofen/administration & dosage/adverse effects/*therapeutic use MH - Male MH - Molar, Third/*surgery MH - Oxycodone/administration & dosage/adverse effects/*therapeutic use MH - Pain, Postoperative/classification/*drug therapy EDAT- 2005/06/01 09:00 MHDA- 2005/07/21 09:00 CRDT- 2005/06/01 09:00 PHST- 2005/03/14 00:00 [accepted] PHST- 2005/06/01 09:00 [pubmed] PHST- 2005/07/21 09:00 [medline] PHST- 2005/06/01 09:00 [entrez] AID - S0149-2918(05)00066-4 [pii] AID - 10.1016/j.clinthera.2005.04.010 [doi] PST - ppublish SO - Clin Ther. 2005 Apr;27(4):418-29. doi: 10.1016/j.clinthera.2005.04.010. PMID- 30145662 OWN - NLM STAT- MEDLINE DCOM- 20191216 LR - 20200225 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 23 IP - 4 DP - 2019 Apr TI - Dental management of patient with dual antiplatelet therapy: a meta-analysis. PG - 1615-1623 LID - 10.1007/s00784-018-2591-y [doi] AB - BACKGROUND: It is more common to need dual antiplatelet therapy (DAPT) for patients who had recently inserted coronary artery stent. However, the postoperative bleeding risk of patients in DAPT could significantly increase. The dental management of patients with antithrombotic therapy has always been a controversial problem. Focusing on this issue, this review discussed the available evidence to provide optimal strategy for patients taking dual antiplatelet agents in the dental setting. METHODS: We searched the PubMed, Embase, ScienceDirect, Web of Science (WOS), Cochrane Library, and China National Knowledge Infrastructure (CNKI) which was performed in May 2018. Relevant articles were included according to our inclusion and exclusion criteria. Meta-analysis was conducted with fixed effects models. Subgroup analysis was used due to different dental surgeries. RESULTS: Our meta-analysis included ten studies (continue DAPT vs. placebo, 535 patients vs.2907 patients). The quantitative results indicated that the risk of postoperative bleeding with continuing DAPT experienced significantly increase (RR = 1.95 95% CI [1.07, 3.54]; p = 0.03). There was no statistically significant difference between the postoperative bleeding rate and different dental surgeries (p = 0.72). CONCLUSION: On the current studies, postoperative hemorrhage is exacerbated with DAPT, but it could be controlled by enhancing hemostasis methods. We recommend continuing long-term DAPT before tooth extraction. CLINICAL RELEVANCE: In this work, we systematically evaluated and summarized the results of small clinical trials after reviewing the present literatures on this topic, so that we could propose more objective and more accurate evidence-based recommendations on dental management for patient with dual antiplatelet therapy. FAU - Li, Lin AU - Li L AD - Dental Student, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China. FAU - Zhang, Wenyi AU - Zhang W AD - Department of Prosthodontics, Hospital of Stomatology, Tianjin Medical University, Tianjin, China. FAU - Yang, Yun AU - Yang Y AD - Dental Student, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China. FAU - Zhao, Liyuan AU - Zhao L AD - Dental Student, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China. FAU - Zhou, Xinyao AU - Zhou X AD - Dental Student, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China. FAU - Zhang, Jian AU - Zhang J AUID- ORCID: 0000-0002-7406-2816 AD - Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Tianjin Medical University, Tianjin, China. zj301doctor@126.com. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20180825 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Platelet Aggregation Inhibitors) SB - D MH - China MH - Dental Care MH - Drug Therapy, Combination MH - *Dual Anti-Platelet Therapy/adverse effects MH - Humans MH - *Platelet Aggregation Inhibitors MH - *Postoperative Hemorrhage OTO - NOTNLM OT - Bleeding OT - Dental extraction OT - Dual antiplatelet therapy OT - Meta-analysis EDAT- 2018/08/27 06:00 MHDA- 2019/12/18 06:00 CRDT- 2018/08/27 06:00 PHST- 2017/10/04 00:00 [received] PHST- 2018/08/20 00:00 [accepted] PHST- 2018/08/27 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2018/08/27 06:00 [entrez] AID - 10.1007/s00784-018-2591-y [pii] AID - 10.1007/s00784-018-2591-y [doi] PST - ppublish SO - Clin Oral Investig. 2019 Apr;23(4):1615-1623. doi: 10.1007/s00784-018-2591-y. Epub 2018 Aug 25. PMID- 29038624 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 0972-8279 (Print) IS - 0974-942X (Electronic) IS - 0972-8270 (Linking) VI - 16 IP - 4 DP - 2017 Dec TI - Comparing the Efficiency of Two Different Extraction Techniques in Removal of Maxillary Third Molars: A Randomized Controlled Trial. PG - 424-429 LID - 10.1007/s12663-016-0935-1 [doi] AB - INTRODUCTION: Extractions are routine procedures in dental surgery. Traditional extraction techniques use a combination of severing the periodontal attachment, luxation with an elevator, and removal with forceps. A new technique of extraction of maxillary third molar is introduced in this study-Joedds technique, which is compared with the conventional technique. METHODS AND MATERIAL: One hundred people were included in the study, the people were divided into two groups by means of simple random sampling. In one group conventional technique of maxillary third molar extraction was used and on second Joedds technique was used. Statistical analysis was carried out with student's t test. RESULTS: Analysis of 100 patients based on parameters showed that the novel joedds technique had minimal trauma to surrounding tissues, less tuberosity and root fractures and the time taken for extraction was <2 min while compared to other group of patients. CONCLUSION: This novel technique has proved to be better than conventional third molar extraction technique, with minimal complications. If Proper selection of cases and right technique are used. FAU - Edward, Joseph AU - Edward J AD - Department of Oral and Maxillo facial Surgery, Azeezia College of Dental Science and Research, Diamond Hills, Meeyannur, Kollam, 691537 India. FAU - Aziz, Mubarak A AU - Aziz MA AD - Department of Oral and Maxillo facial Surgery, Azeezia College of Dental Science and Research, Diamond Hills, Meeyannur, Kollam, 691537 India. FAU - Madhu Usha, Arjun AU - Madhu Usha A AUID- ORCID: 0000-0001-5190-0971 AD - Department of Oral and Maxillo facial Surgery, Azeezia College of Dental Science and Research, Diamond Hills, Meeyannur, Kollam, 691537 India. FAU - Narayanan, Jyothi K AU - Narayanan JK AD - Department of Oral and Maxillo facial Surgery, Azeezia College of Dental Science and Research, Diamond Hills, Meeyannur, Kollam, 691537 India. LA - eng PT - Journal Article DEP - 20160713 TA - J Maxillofac Oral Surg JT - Journal of maxillofacial and oral surgery JID - 101538309 EIN - J Maxillofac Oral Surg. 2017 Dec;16(4):430. PMID: 29044249 PMC - PMC5628062 OTO - NOTNLM OT - Extraction OT - Joedds technique OT - Maxillary third molar COIS- None. EDAT- 2017/10/19 06:00 MHDA- 2017/10/19 06:01 CRDT- 2017/10/18 06:00 PHST- 2015/10/08 00:00 [received] PHST- 2016/06/17 00:00 [accepted] PHST- 2017/10/18 06:00 [entrez] PHST- 2017/10/19 06:00 [pubmed] PHST- 2017/10/19 06:01 [medline] AID - 935 [pii] AID - 10.1007/s12663-016-0935-1 [doi] PST - ppublish SO - J Maxillofac Oral Surg. 2017 Dec;16(4):424-429. doi: 10.1007/s12663-016-0935-1. Epub 2016 Jul 13. PMID- 27790577 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2249-782X (Print) IS - 0973-709X (Electronic) IS - 0973-709X (Linking) VI - 10 IP - 9 DP - 2016 Sep TI - Hemostasis and Post-operative Care of Oral Surgical Wounds by Hemcon Dental Dressing in Patients on Oral Anticoagulant Therapy: A Split Mouth Randomized Controlled Clinical Trial. PG - ZC37-ZC40 AB - INTRODUCTION: Hemostasis is a fundamental management issue post-operatively in minor oral surgical procedures. To ensure safety and therapeutic efficacy in patients, under oral anti coagulant therapy, is complicated by necessity for frequent determination of prothrombin time or international normalised ratio. AIM: The aim of the study was to determine whether early hemostasis achieved by using Hemcon Dental Dressing (HDD) will affect post-operative care and surgical healing outcome in minor oral surgical procedures. MATERIALS AND METHODS: A total of 30 patients, aged 18 years to 90 years, except those allergic to seafood, who consented to participate, were enrolled into this study. Patients were required to have two or more surgical sites so that they would have both surgical and control sites. All patients taking Oral Anticoagulation Therapy (OAT) were included for treatment in the study without altering the anticoagulant regimens. Institutional Review Board approval was obtained for the same. The collected data was subjected to statistical analysis using unpaired t-test. RESULTS: All HDD surgically treated sites achieved hemostasis in 1.49 minutes and control wounds in 4.06 minutes (p < 0.001). Post-operative pain at HDD treated sites (1.87,1.27 on 1(st) and 3(rd) day respectively) was significantly lower than the control sites (4.0,1.87 on 1(st) and 3(rd) day respectively) p-value (0.001, 0.001 respectively). HDD treated oral surgery wounds achieved statistically significant improved healing both at 1(st) and 3(rd) post-operative days (p <0.0001). CONCLUSION: The HDD has been proven to be a clinically effective hemostatic dressing material that significantly shortens bleeding time following minor oral surgical procedures under local anaesthesia, including those patients taking OAT. Patients receiving the HDD had improved surgical wound healing as compared to controls. FAU - Kumar, K R Ashok AU - Kumar KR AD - Head of the Department, Department of Oral and Maxillofacial Surgery, Sri Siddhartha Dental College , Tumkur, Karnataka, India . FAU - Kumar, Jambukeshwar AU - Kumar J AD - Senior Lecturer, Department of Oral and Maxillofacial Surgery, Vishnu Dental Collage , Bhimavaram, Andhra Pradesh, India . FAU - Sarvagna, Jagadesh AU - Sarvagna J AD - Consultant Oral Oncologist, Siddhagiri Hospital , Kolhapur, Maharashtra, India . FAU - Gadde, Praveen AU - Gadde P AD - Senior Lecturer, Department of Public Health Dentistry, Vishnu Dental College , Bhimavaram, Andhrapradesh, India . FAU - Chikkaboriah, Shwetha AU - Chikkaboriah S AD - Postgraduate, Department of Periodontics, Vakkaligara Sanga Dental College , Bangalore, Karnataka, India . LA - eng PT - Journal Article DEP - 20160901 TA - J Clin Diagn Res JT - Journal of clinical and diagnostic research : JCDR JID - 101488993 PMC - PMC5072077 OTO - NOTNLM OT - Bleeding OT - Chitosan dressing OT - Extraction wound healing OT - International normalised ratio OT - Minor oral surgery EDAT- 2016/10/30 06:00 MHDA- 2016/10/30 06:01 CRDT- 2016/10/30 06:00 PHST- 2015/10/11 00:00 [received] PHST- 2016/05/04 00:00 [accepted] PHST- 2016/10/30 06:00 [pubmed] PHST- 2016/10/30 06:01 [medline] PHST- 2016/10/30 06:00 [entrez] AID - 10.7860/JCDR/2016/17275.8462 [doi] PST - ppublish SO - J Clin Diagn Res. 2016 Sep;10(9):ZC37-ZC40. doi: 10.7860/JCDR/2016/17275.8462. Epub 2016 Sep 1. PMID- 9469523 OWN - NLM STAT- MEDLINE DCOM- 19980324 LR - 20210112 IS - 0304-3959 (Print) IS - 0304-3959 (Linking) VI - 73 IP - 3 DP - 1997 Dec TI - Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)-flurbiprofen following extraction of impacted third molars. PG - 339-345 LID - 10.1016/S0304-3959(97)00120-6 [doi] AB - Post-operative pain and inflammation are frequently managed with non-steroidal anti-inflammatory drugs (NSAIDs). Despite the prevalence of their use, however, relatively little is known about in vivo tissue concentrations of inflammatory mediators at the site of tissue injury and their modulation by NSAIDs. This study compares the effect of oral administration of the NSAID flurbiprofen, to placebo, on tissue levels of immunoreactive prostaglandin E2 (iPGE2), leukotriene B4 (iLTB4), and (S)-flurbiprofen within the surgical wound using implanted microdialysis probes in the dental impaction pain model. Twenty-four healthy patients in need of extraction of partial to complete bony mandibular third molars were recruited for this randomized, double-blind, placebo-controlled study. Following pre-operative administration of N2O/O2, midazolam i.v., and regional block anesthesia with 3% mepivacaine, each patient underwent surgical removal of their impacted third molars. Immediately following completion of the surgery, two semi-permeable microdialysis probes (3 kDa molecular weight cut-off) were implanted into each mandibular surgical site. Patients were taken to a recovery room and microdialysis samples and patient pain reports (visual analog scale, VAS) were collected at 30 min intervals for 4 h. Patients randomly received either flurbiprofen (200 mg orally) or placebo at the onset of post-operative pain. Dialysate samples were collected, frozen, and later assayed for iPGE2, iLTB4, and (S)-flurbiprofen levels. Results of this study show that flurbiprofen decreased post-operative pain by approximately 70% compared to placebo-treated patients (P < 0.001). During the 4 h post-operative timecourse of this study, flurbiprofen treatment significantly reduced peak tissue levels of iPGE2 (9.2 +/- 2.6 vs. 0.4 +/- 0.15 nM; P < 0.001), without having a significant effect on peak tissue levels of iLTB4 (2.5 +/- 1.4 vs. 1.49 +/- 0.86 nM) compared to placebo treatment. Levels of (S)-flurbiprofen significantly increased within the surgical wound exceeding therapeutic levels by 60 min after administration. Flurbiprofen is able to significantly suppress the local production of iPGE2 and provide significant analgesic efficacy without altering iLTB4 tissue levels in this model of acute post-operative inflammatory pain. These data indicate that NSAIDs selectively alter eicosanoid levels within surgical wound and evoke analgesia at time points coincident with elevated wound levels of the drug. The combined use of microdialysis probes in awake patients who provide simultaneous pain reports may offer insight into peripheral mechanisms of inflammatory mediator release and pain. FAU - Roszkowski, Mark T AU - Roszkowski MT AD - Division of Oral and Maxillofacial Surgery, University of Minnesota, School of Dentistry, Minneapolis, MN 55455, USA Department of Oral Science, University of Minnesota, School of Dentistry, Minneapolis, MN 55455, USA Department of Restorative Sciences, University of Minnesota, School of Dentistry, Minneapolis, MN 55455, USA Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. FAU - Swift, James Q AU - Swift JQ FAU - Hargreaves, Kenneth M AU - Hargreaves KM LA - eng GR - K16DE0027/DE/NIDCR NIH HHS/United States GR - P30DE09737/DE/NIDCR NIH HHS/United States GR - R01DE11277/DE/NIDCR NIH HHS/United States GR - etc. PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Cyclooxygenase Inhibitors) RN - 1HGW4DR56D (Leukotriene B4) RN - 5GRO578KLP (Flurbiprofen) RN - K7Q1JQR04M (Dinoprostone) SB - IM MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/analysis/*therapeutic use MH - Cyclooxygenase Inhibitors/adverse effects/analysis/*therapeutic use MH - Dinoprostone/*analysis MH - Double-Blind Method MH - Flurbiprofen/adverse effects/analysis/*therapeutic use MH - Humans MH - Immunohistochemistry MH - Leukotriene B4/*analysis MH - Microdialysis MH - Molar, Third MH - *Tooth Extraction MH - Tooth, Impacted MH - Wounds and Injuries/drug therapy/metabolism EDAT- 1998/02/20 00:00 MHDA- 1998/02/20 00:01 CRDT- 1998/02/20 00:00 PHST- 1998/02/20 00:00 [pubmed] PHST- 1998/02/20 00:01 [medline] PHST- 1998/02/20 00:00 [entrez] AID - 00006396-199712000-00007 [pii] AID - 10.1016/S0304-3959(97)00120-6 [doi] PST - ppublish SO - Pain. 1997 Dec;73(3):339-345. doi: 10.1016/S0304-3959(97)00120-6. PMID- 29133965 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 0898-5901 (Print) IS - 1884-7269 (Electronic) IS - 0898-5901 (Linking) VI - 26 IP - 3 DP - 2017 Sep 30 TI - Evaluation of adjunctive effect of low-level laser Therapy on pain, swelling and trismus after surgical removal of impacted lower third molar: A double blind randomized clinical trial. PG - 181-187 LID - 10.5978/islsm.17-OR-13 [doi] AB - BACKGROUND AND AIM: Wisdom teeth remains impacted in the jaw due to several reasons and surgery of impacted wisdom teeth is one of the most common surgeries in dental clinics. Pain, swelling and trismus are the common complications after this surgery which affect quality of life. In articles, various methods are introduced to control immediate inflammatory-response associated with third-molar surgery. The aim of this study is to evaluate the adjunctive effect of low-level laser Therapy on pain, swelling and trismus after surgical removal of impacted lower third molar. MATERIALS AND METHODS: This double-blind randomized controlled trial (RCT) was conducted on two groups of 24 patients (age range of 18-35) that had referred to surgical ward of Faculty of Dentistry, Tabriz University of Medical Sciences for surgery of their mandibular third molar(2015-16). All the subjects were systemically healthy and had at least one impacted mandibular third molar. After surgery, in experimental group, the laser was applied intraorally (inside the tooth socket) and extraorally (at the insertion point of the masseter muscle) immediately after surgery in contact with the target area for 25 seconds each. The laser energy was 2.5 J per area with an energy density of 5 J/ cm(2) at the surface of the probe (spot size= 0.5 cm(2)). In the other group, as the control group, it was pretended to radiate. Trismus, pain, and swelling were evaluated on the first and seventh days after surgery. The obtained data were evaluated using SPSS 16 software and independent samples T-test. FINDINGS: In the group where LLLT had been used, P> 0.05 was calculated for pain, swelling, and trismus on days 1 and 7 after surgery that was not statistically significant. CONCLUSION: Under limitations of this study, using low-power laser with mentioned parameters, clinically reduces pain, swelling and trismus after surgical removal of impacted mandibular wisdom, but not statistically significant. FAU - Farhadi, Farrokh AU - Farhadi F AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Eslami, Hosein AU - Eslami H AD - Department of Oral and Maxillofacial Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Majidi, Alireza AU - Majidi A AD - Department of Endodontic, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Fakhrzadeh, Vahid AU - Fakhrzadeh V AD - Department of Prosthodontics, School of Dentistry, Tabriz Univarsity of Medical Sciences, Tabriz, Iran. FAU - Ghanizadeh, Milad AU - Ghanizadeh M AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - KhademNeghad, Sahar AU - KhademNeghad S AD - Department of Oral and Maxillofacial Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. LA - eng PT - Journal Article TA - Laser Ther JT - Laser therapy JID - 8914401 PMC - PMC5675908 OTO - NOTNLM OT - Low level laser Therapy (LLLT) OT - Pain, Lower third molar OT - Trismus OT - swelling EDAT- 2017/11/15 06:00 MHDA- 2017/11/15 06:01 CRDT- 2017/11/15 06:00 PHST- 2017/01/27 00:00 [received] PHST- 2017/08/04 00:00 [accepted] PHST- 2017/11/15 06:00 [entrez] PHST- 2017/11/15 06:00 [pubmed] PHST- 2017/11/15 06:01 [medline] AID - 10.5978/islsm.17-OR-13 [doi] PST - ppublish SO - Laser Ther. 2017 Sep 30;26(3):181-187. doi: 10.5978/islsm.17-OR-13. PMID- 30116513 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2029-283X (Print) IS - 2029-283X (Electronic) IS - 2029-283X (Linking) VI - 9 IP - 2 DP - 2018 Apr-Jun TI - Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review. PG - e1 LID - 10.5037/jomr.2018.9201 [doi] LID - e1 AB - OBJECTIVES: The objective of the present systematic review was to test the hypothesis of no difference in facial swelling, pain and trismus after surgical removal of mandibular third molar with different dosages of corticosteroids and administration routes. MATERIAL AND METHODS: A MEDLINE (PubMed), Embase database and Cochrane Library search in combination with a hand-search of relevant journals was conducted by including randomized controlled trials published in English until 1(st) December 2017. RESULTS: Seven studies fulfilled the inclusion criteria. Considerable variation in the included studies prevented meta-analysis from being performed. Preoperative submucosal injection of corticosteroids significantly diminishes facial swelling, pain and trismus compared with placebo. However, different dosages of corticosteroid and administration routes reveal contrary results indicating that administration of a higher dosage of corticosteroids do not necessarily cause a further decrease in facial swelling, pain and trismus. CONCLUSIONS: Consequently, the optimal dosage of corticosteroids and administration route for diminishing postsurgical morbidity and improve quality of life after surgical removal of mandibular third molar is presently unknown. Therefore, further well-designed randomized clinical trials including a standardised protocol, patient-reported outcome measures and three-dimensional analysis of facial swelling is needed. FAU - Larsen, Marie Kjærgaard AU - Larsen MK AD - Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, AalborgDenmark. FAU - Kofod, Thomas AU - Kofod T AD - Department of Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen University Hospital, CopenhagenDenmark. FAU - Christiansen, Ann-Eva AU - Christiansen AE AD - Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark. FAU - Starch-Jensen, Thomas AU - Starch-Jensen T AD - Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, AalborgDenmark. LA - eng PT - Journal Article PT - Review DEP - 20180629 TA - J Oral Maxillofac Res JT - Journal of oral & maxillofacial research JID - 101552108 PMC - PMC6090248 OTO - NOTNLM OT - corticosteroids OT - dentistry OT - edema OT - molar OT - pain OT - trismus EDAT- 2018/08/18 06:00 MHDA- 2018/08/18 06:01 CRDT- 2018/08/18 06:00 PHST- 2018/05/08 00:00 [received] PHST- 2018/06/25 00:00 [accepted] PHST- 2018/08/18 06:00 [entrez] PHST- 2018/08/18 06:00 [pubmed] PHST- 2018/08/18 06:01 [medline] AID - v9n2e1ht [pii] AID - 10.5037/jomr.2018.9201 [doi] PST - epublish SO - J Oral Maxillofac Res. 2018 Jun 29;9(2):e1. doi: 10.5037/jomr.2018.9201. eCollection 2018 Apr-Jun. PMID- 11781224 OWN - NLM STAT- MEDLINE DCOM- 20020213 LR - 20210216 IS - 0006-4971 (Print) IS - 0006-4971 (Linking) VI - 99 IP - 2 DP - 2002 Jan 15 TI - Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study. PG - 450-6 AB - Among patients with von Willebrand disease (VWD) who are unresponsive to desmopressin therapy, replacement with plasma-derived concentrates is the treatment of choice. Because prospective studies are lacking, such treatment has been largely empirical. A multicenter, prospective study has been conducted in 81 patients with VWD (15 patients with type 1, 34 with type 2, and 32 with type 3 disease) to investigate the efficacy of a high-purity factor VIII/von Willebrand factor (FVIII/VWF) concentrate for treatment of bleeding and surgical prophylaxis. Two preparations of the concentrate-one virally inactivated with solvent detergent, the other with an additional heat-treatment step--were evaluated. Pharmacokinetic parameters were similar for both preparations. Using pre-established dosages based on the results of pharmacokinetic studies, 53 patients were administered either preparation for the treatment of 87 bleeding episodes, and 39 patients were treated prophylactically for 71 surgical or invasive procedures. Sixty-five (74.7%) and 10 (11.5%) of the bleeding episodes were controlled with 1 or 2 infusions, respectively. Patients with severe type 3 VWD typically required more infusions and higher doses, at shorter time intervals, than did patients with generally milder types 1 and 2. Among patients undergoing surgical procedures, blood loss was lower than that predicted prospectively, and losses exceeding the predicted value did not correlate with the postinfusion skin bleeding time. In conclusion, the concentrate effectively stopped active bleeding and provided adequate hemostasis for surgical or invasive procedures, even in the absence of bleeding time correction. FAU - Mannucci, Pier M AU - Mannucci PM AD - Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy. FAU - Chediak, Juan AU - Chediak J FAU - Hanna, Wahid AU - Hanna W FAU - Byrnes, John AU - Byrnes J FAU - Ledford, Marlies AU - Ledford M FAU - Ewenstein, Bruce M AU - Ewenstein BM FAU - Retzios, Anastassios D AU - Retzios AD FAU - Kapelan, Barbara A AU - Kapelan BA FAU - Schwartz, Richard S AU - Schwartz RS FAU - Kessler, Craig AU - Kessler C CN - Alphanate Study Group LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PL - United States TA - Blood JT - Blood JID - 7603509 RN - 0 (Detergents) RN - 0 (Solvents) RN - 0 (von Willebrand Factor) RN - 9001-27-8 (Factor VIII) SB - AIM SB - IM MH - Adolescent MH - Adult MH - Aged MH - Blood Loss, Surgical MH - Child MH - Cross-Over Studies MH - Detergents MH - Dose-Response Relationship, Drug MH - Elective Surgical Procedures MH - Factor VIII/isolation & purification/pharmacokinetics/*therapeutic use MH - Female MH - Hemorrhage/epidemiology/etiology/prevention & control MH - Hot Temperature MH - Humans MH - Infusions, Intravenous MH - Male MH - Middle Aged MH - Postoperative Hemorrhage/epidemiology/etiology/prevention & control MH - Prospective Studies MH - Safety MH - Solvents MH - Thrombophlebitis/etiology MH - Tooth Extraction MH - Treatment Outcome MH - von Willebrand Diseases/*drug therapy MH - von Willebrand Factor/chemistry/isolation & purification/pharmacokinetics/*therapeutic use EDAT- 2002/01/10 10:00 MHDA- 2002/02/14 10:01 CRDT- 2002/01/10 10:00 PHST- 2002/01/10 10:00 [pubmed] PHST- 2002/02/14 10:01 [medline] PHST- 2002/01/10 10:00 [entrez] AID - S0006-4971(20)38323-3 [pii] AID - 10.1182/blood.v99.2.450 [doi] PST - ppublish SO - Blood. 2002 Jan 15;99(2):450-6. doi: 10.1182/blood.v99.2.450. PMID- 25432449 OWN - NLM STAT- MEDLINE DCOM- 20150329 LR - 20150226 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 2 DP - 2015 Feb TI - Is erbium:yttrium-aluminum-garnet laser versus conventional rotary osteotomy better in the postoperative period for lower third molar surgery? Randomized split-mouth clinical study. PG - 211-8 AB - PURPOSE: Lasers have been extensively used in dentistry for several applications. We investigated and compared the use of an erbium:yttrium-aluminum-garnet laser and conventional rotary instruments for bone removal in third molar surgery. MATERIALS AND METHODS: We implemented a randomized, split-mouth clinical trial. Patients with bilateral and symmetrical third molar impaction referred to the Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, were enrolled in the study. Each patient was treated once with the erbium:yttrium-aluminum-garnet laser and once with conventional rotary instruments for bone removal during third molar surgery. Pain, swelling, and trismus were taken into account to match the 2 techniques.In addition, the times required to complete osteotomy and for the full operation were recorded. Descriptive and bivariate statistics were computed, and the P value was set at .05. RESULTS: The sample was composed of 15 patients (8 men and 7 women) ranging in age from 18 to 30 years. Pain perceived in the laser-treated group was significantly less than that in the conventional group(P = .0013). This also was true for trismus (P = .0002) and swelling. The operating time for osteotomy was longer in the laser group. CONCLUSIONS: The results of this study suggest that the laser could be an interesting alternative to conventional rotary instruments. Future studies with a larger number of patients are required to confirm the conclusions achieved from this work. FAU - Romeo, Umberto AU - Romeo U FAU - Libotte, Fabrizio AU - Libotte F FAU - Palaia, Gaspare AU - Palaia G FAU - Tenore, Gianluca AU - Tenore G FAU - Galanakis, Alexandros AU - Galanakis A FAU - Annibali, Susanna AU - Annibali S LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 58784XQC3Y (Yttrium) RN - 77B218D3YE (Erbium) RN - CPD4NFA903 (Aluminum) SB - AIM SB - D SB - IM MH - Aluminum MH - Erbium MH - Humans MH - Laser Therapy MH - *Osteotomy MH - *Postoperative Period MH - Yttrium EDAT- 2014/11/30 06:00 MHDA- 2015/03/31 06:00 CRDT- 2014/11/30 06:00 PHST- 2014/04/20 00:00 [received] PHST- 2014/07/30 00:00 [revised] PHST- 2014/08/03 00:00 [accepted] PHST- 2014/11/30 06:00 [entrez] PHST- 2014/11/30 06:00 [pubmed] PHST- 2015/03/31 06:00 [medline] AID - S0278-2391(14)01320-2 [pii] AID - 10.1016/j.joms.2014.08.013 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Feb;73(2):211-8. doi: 10.1016/j.joms.2014.08.013. PMID- 30632329 OWN - NLM STAT- MEDLINE DCOM- 20190227 LR - 20190227 IS - 1819-2718 (Electronic) IS - 1025-9589 (Linking) VI - 30 IP - 4 DP - 2018 Oct-Dec TI - Role Of 0.2% Bio-Adhesive Chlorhexidine Gel In Reducing Incidence Of Alveolar Osteitis. PG - 524-528 AB - BACKGROUND: Alveolar osteitis is a frequent postoperative complication of third molar surgery. A number of preventive methods have been tried. Chlorhexidine is most widely used antiseptic which is thought to be helpful to prevent alveolar osteitis. The objective of this study was to evaluate role of 0.2% bio-adhesive chlorhexidine gel in reducing incidence of alveolar osteitis after surgical removal of mandibular third molars which causes extra monetary burden on the patients in the form of several follow up visits.. METHODS: A randomized clinical trial was performed in the Dental Section, Ayub Medical College, Abbottabad. Approval from ethical committee was obtained. Total 180 patients were randomly divided into Group A in which patients received 0.2% bio-adhesive chlorhexidine gel and Group B where patients received placebo gel in the extraction socket after removal of mandibular third molar. RESULTS: 0.2% bio-adhesive chlorhexidine gel used after mandibular third molar removal reduced incidence of alveolar osteitis by 10% in comparison to control group with statistically significant difference, i.e., p=0.044.. CONCLUSIONS: 2.3 times reduction in the incidence of alveolar osteitis was observed after use of 0.2% bio-adhesive chlorhexidine gel. FAU - Shad, Samia AU - Shad S AD - Dental Section, Abbottabad International Medical College, Abbottabad-Pakistan. FAU - Hussain, Syed Majid AU - Hussain SM AD - Department of Dentistry, Ayub Medical College, Abbottabad, Pakistan. FAU - Tahir, Muhammad Waheed AU - Tahir MW AD - Allama Iqbal Medical College/ Jinnah Hospital Lahore, Pakistan. FAU - Rahat Geelani, Syeda Rabia AU - Rahat Geelani SR AD - Dental Section, Abbottabad International Medical College, Abbottabad, Pakistan. FAU - Khan, Saqib Mehmood AU - Khan SM AD - Dental Section, Abbottabad International Medical College, Abbottabad, Pakistan. FAU - Abbasi, Masroor Manshad AU - Abbasi MM AD - Frontier Medical & Dental College, Abbottabad, Pakistan. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Pakistan TA - J Ayub Med Coll Abbottabad JT - Journal of Ayub Medical College, Abbottabad : JAMC JID - 8910750 RN - 0 (Adhesives) RN - 0 (Anti-Infective Agents, Local) RN - 0 (Gels) RN - R4KO0DY52L (Chlorhexidine) SB - IM MH - Adhesives MH - Anti-Infective Agents, Local/*therapeutic use MH - Chlorhexidine/*therapeutic use MH - *Dry Socket/drug therapy/epidemiology/prevention & control MH - Gels MH - Humans OTO - NOTNLM OT - Alveolar Osteitis OT - Dry Socket; Chlorhexidine Gel OT - Mandibular Third Molar EDAT- 2019/01/12 06:00 MHDA- 2019/02/28 06:00 CRDT- 2019/01/12 06:00 PHST- 2019/01/12 06:00 [entrez] PHST- 2019/01/12 06:00 [pubmed] PHST- 2019/02/28 06:00 [medline] AID - 4494/2023 [pii] PST - ppublish SO - J Ayub Med Coll Abbottabad. 2018 Oct-Dec;30(4):524-528. PMID- 17510716 OWN - NLM STAT- MEDLINE DCOM- 20070926 LR - 20210227 IS - 0033-6572 (Print) IS - 0033-6572 (Linking) VI - 38 IP - 2 DP - 2007 Feb TI - Pulp responses to the application of a self-etching adhesive in human pulps after controlling bleeding with sodium hypochlorite. PG - e67-77 AB - OBJECTIVE: To evaluate the pulp response to direct capping with self-etching adhesive systems using sodium hypochlorite as a hemostatic agent. METHOD AND MATERIALS: Twenty-six human third molars scheduled for extraction were selected from undergraduate students of dentistry. Class I cavities with pulp exposures were performed. To control bleeding, 2.5% sodium hypochlorite was used for 20 seconds, followed by washing with saline solution. The pulp exposures were capped with calcium hydroxide (n = 10) or adhesive system (n = 16). All cavities were restored with adhesive system and composite resin. Half of the samples of each capping material were extracted after 30 days and the remaining after 90 days. The samples were prepared for histological analysis (hematoxylin-eosin) and bacterial detection (Brown & Hopps) and evaluated according to standard ranking. Data were submitted to statistical analysis (Mann-Whitney test). RESULTS: There was a significant difference (P <.05) only in relation to dentin barrier formation. Pulps dressed with calcium hydroxide showed dentin barrier formation in all specimens, obliterating the exposure site. No inflammatory response was associated with material. In the experimental group, after 30 days, there was an attempt for healing with reparative dentin deposition, presenting a mild to moderate inflammatory infiltrate. Similar findings were found after 90 days, decreasing the inflammatory response. Bacteria were not detected in any specimen evaluated. Sodium hypochlorite was effective for hemostatic control. CONCLUSION: Calcium hydroxide produced better biological performance than the self-etching adhesive, and sodium hypochlorite did not interfere with the pulp repair. FAU - Elias, Raquel V AU - Elias RV AD - Department of Operative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil. FAU - Demarco, Flavio F AU - Demarco FF FAU - Tarquinio, Sandra B C AU - Tarquinio SB FAU - Piva, Evandro AU - Piva E LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 RN - 0 (Clearfil SE Bond) RN - 0 (Oxidants) RN - 0 (Resin Cements) RN - DY38VHM5OD (Sodium Hypochlorite) RN - PF5DZW74VN (Calcium Hydroxide) SB - D MH - Calcium Hydroxide/pharmacology MH - Dental Pulp/*drug effects MH - Dental Pulp Capping/*methods MH - Hemostasis, Surgical/methods MH - Humans MH - Oxidants/*pharmacology MH - Resin Cements/pharmacology MH - Sodium Hypochlorite/*pharmacology MH - Statistics, Nonparametric EDAT- 2007/05/19 09:00 MHDA- 2007/09/27 09:00 CRDT- 2007/05/19 09:00 PHST- 2007/05/19 09:00 [pubmed] PHST- 2007/09/27 09:00 [medline] PHST- 2007/05/19 09:00 [entrez] AID - 839751 [pii] PST - ppublish SO - Quintessence Int. 2007 Feb;38(2):e67-77. PMID- 23390473 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130208 LR - 20200930 IS - 1918-3003 (Print) IS - 1918-3011 (Electronic) IS - 1918-3003 (Linking) VI - 5 IP - 1 DP - 2013 Feb TI - A single dose of amoxicillin and dexamethasone for prevention of postoperative complications in third molar surgery: a randomized, double-blind, placebo controlled clinical trial. PG - 26-33 LID - 10.4021/jocmr1160w [doi] AB - BACKGROUND: The aim of this study was to assess the efficacy of a single prophylactic dose of amoxicillin and/or dexamethasone in preventing postoperative complications (PC) after a surgical removal of a single mandibular third molar (M3). METHODS: This study is a randomized, placebo controlled clinical trial. Four groups were included: Group 1 (G1) included a prophylactic dose of 2 g of amoxicillin and 8 mg of dexamethasone; Group 2 (G2) included a prophylactic dose of 2 g of amoxicillin and 8 mg of placebo; Group 3 (G3) included a prophylactic dose of 8 mg of dexamethasone and 2 g of placebo and; Group 4 (G4) placebo. RESULTS: Fifty patients were included. It was observed one case of alveolar infection (2%) and two of alveolar osteitis (4%) resulting in three PC (6%). No statistical differences were observed between therapeutic groups for development of PC, trismus, pain and edema. The use of antibiotics showed an absolute risk reduction (ARR) for PC development of 3.52% and the number needed to treat (NNT) was 29. CONCLUSION: Prophylactic antibiotics and corticoid in a single dose regimen did not bring any benefit on M3 surgeries. FAU - Bortoluzzi, Marcelo Carlos AU - Bortoluzzi MC AD - School of Dentistry, Health Bioscience Postgraduate Program, Tissue Aspects for Health Prognosis and Intervention Laboratory (LAPROG), Oeste de Santa Catarina University (UNOESC), Brazil. FAU - Capella, Diogo Lenzi AU - Capella DL FAU - Barbieri, Tharzon AU - Barbieri T FAU - Pagliarini, Micheli AU - Pagliarini M FAU - Cavalieri, Talita AU - Cavalieri T FAU - Manfro, Rafael AU - Manfro R LA - eng PT - Journal Article DEP - 20130111 TA - J Clin Med Res JT - Journal of clinical medicine research JID - 101538301 PMC - PMC3564565 OTO - NOTNLM OT - Amoxicillin OT - Antibiotic prophylaxis OT - Dexamethasone OT - Third molar surgery EDAT- 2013/02/08 06:00 MHDA- 2013/02/08 06:01 CRDT- 2013/02/08 06:00 PHST- 2012/10/11 00:00 [accepted] PHST- 2013/02/08 06:00 [entrez] PHST- 2013/02/08 06:00 [pubmed] PHST- 2013/02/08 06:01 [medline] AID - 10.4021/jocmr1160w [doi] PST - ppublish SO - J Clin Med Res. 2013 Feb;5(1):26-33. doi: 10.4021/jocmr1160w. Epub 2013 Jan 11. PMID- 33720109 OWN - NLM STAT- Publisher LR - 20210315 IS - 2689-8381 (Electronic) IS - 2689-8381 (Linking) DP - 2021 Mar 11 TI - Postoperative oral drug regimen to control the inflammatory complications in mandibular third molar surgery: a systematic review and network meta-analysis protocol. LID - 10.11124/JBIES-20-00368 [doi] AB - OBJECTIVE: This network meta-analysis aims to rank the best postoperative drug regimen to control inflammatory complications related to mandibular third molar surgery. INTRODUCTION: Many studies of oral drugs have been proposed to control postoperative inflammatory complications after third molar surgeries with inconclusive results. A systematic review with network meta-analysis in this field may clarify the best therapeutic protocol for practice in dentistry. INCLUSION CRITERIA: This review will consider randomized clinical trials that included healthy adult patients or those who had treated and controlled systemic diseases; asymptomatic patients who were free of acute infection or inflammation at the surgical site immediately before third molar surgery; and patients submitted to surgical removal of one lower third molar at a time in which they have received oral anti-inflammatory and/or analgesics in the postoperative moment. The outcomes are pain, edema, trismus, and adverse effects. METHODS: Sources of published studies, unpublished studies, and gray literature will be searched without time or language restrictions. Titles and abstracts of all search results will be screened by two independent reviewers. The full text of potentially relevant studies will be assessed. Methodological quality of the included studies will be performed using the JBI checklist for experimental studies. Data related to specific details about the population, study methods, interventions, and outcomes will be extracted from the included studies. The findings will be presented in a narrative form and polled in network meta-analysis, when possible. SYSTEMATIC REVIEW REGISTRATION NUMBER: PROSPERO CRD42020196692. CI - Copyright © 2021 Joanna Briggs Institute. FAU - de Souza, Glaciele Maria AU - de Souza GM AD - Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina-MG, Brazil. FAU - Magesty, Rafael Alvim AU - Magesty RA FAU - Fernandes, Ighor Andrade AU - Fernandes IA FAU - Sales, Késsia Nara Andrade AU - Sales KNA FAU - Galvão, Endi Lanza AU - Galvão EL FAU - Falci, Saulo Gabriel Moreira AU - Falci SGM LA - eng PT - Journal Article DEP - 20210311 PL - United States TA - JBI Evid Synth JT - JBI evidence synthesis JID - 101764819 SB - IM COIS- The authors declare no conflicts of interest. EDAT- 2021/03/16 06:00 MHDA- 2021/03/16 06:00 CRDT- 2021/03/15 13:07 PHST- 2021/03/15 13:07 [entrez] PHST- 2021/03/16 06:00 [pubmed] PHST- 2021/03/16 06:00 [medline] AID - 02174543-900000000-99708 [pii] AID - 10.11124/JBIES-20-00368 [doi] PST - aheadofprint SO - JBI Evid Synth. 2021 Mar 11. doi: 10.11124/JBIES-20-00368. PMID- 11805771 OWN - NLM STAT- MEDLINE DCOM- 20020508 LR - 20190910 IS - 1079-2104 (Print) IS - 1079-2104 (Linking) VI - 93 IP - 1 DP - 2002 Jan TI - Primary wound healing after lower third molar surgery: evaluation of 2 different flap designs. PG - 7-12 AB - OBJECTIVES: Wound dehiscences after lower third molar surgery potentially extend the time of postsurgical treatment and may cause long-lasting pain. It was the aim of this prospective study to evaluate the primary wound healing of 2 different flap designs. METHODS: Sixty completely covered lower third molars were removed. In 30 cases, the classic envelope flap with a sulcular incision from the first to the second molar and a distal relieving incision to the mandibular ramus was used, whereas the other 30 third molars were extracted after preparation of a modified triangular flap first similarly described by Szmyd. Wound healing was controlled on the first postoperative day, as well as 1 and 2 weeks after surgery. RESULTS: The overall result was a total of 33% wound dehiscence. In the envelope-flap group, wound dehiscences developed in 57% of the cases. This represents a relative risk ratio of 5.67, with a 95% CI from 1.852 to 12.336. With the modified triangular-flap technique, only 10% of the wounds gaped during wound healing. CONCLUSION: This study confirms evidence that the flap design in lower third molar surgery considerably influences primary wound healing. The modified triangular flap is significantly less conducive to the development of wound dehiscence. FAU - Jakse, Norbert AU - Jakse N AD - The Department for Oral Surgery and Radiology, Dental School, Karl-Franzens University Graz, Austria. norbert.jakse@uni-graz.at FAU - Bankaoglu, Vedat AU - Bankaoglu V FAU - Wimmer, Gernot AU - Wimmer G FAU - Eskici, Antranik AU - Eskici A FAU - Pertl, Christof AU - Pertl C LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol Endod JT - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JID - 9508562 SB - D SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Cranial Nerve Injuries/prevention & control MH - Female MH - Humans MH - Lingual Nerve Injuries MH - Male MH - Mandible MH - Middle Aged MH - Prospective Studies MH - Smoking MH - Surgical Flaps MH - Surgical Wound Dehiscence/*etiology/prevention & control MH - Tooth Extraction/*adverse effects/*methods MH - Wound Healing/*physiology EDAT- 2002/01/24 10:00 MHDA- 2002/05/09 10:01 CRDT- 2002/01/24 10:00 PHST- 2002/01/24 10:00 [pubmed] PHST- 2002/05/09 10:01 [medline] PHST- 2002/01/24 10:00 [entrez] AID - S1079210402230152 [pii] AID - 10.1067/moe.2002.119519 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Jan;93(1):7-12. doi: 10.1067/moe.2002.119519. PMID- 23204746 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130108 LR - 20200929 IS - 0974-942X (Electronic) IS - 0972-8279 (Print) IS - 0972-8270 (Linking) VI - 10 IP - 4 DP - 2011 Dec TI - A comparative study: efficacy of tissue glue and sutures after impacted mandibular third molar removal. PG - 310-5 LID - 10.1007/s12663-011-0241-x [doi] AB - OBJECTIVE: To compare the efficacy of cyanoacrylate (tissue glue) placement after surgical removal of impacted mandibular third molars. MATERIALS AND METHODS: Thirty patients with bilaterally impacted mandibular third molars were studied in this controlled clinical trial. One side closure after surgical removal of third molar was done with conventional sutures and other side with cyanoacrylate. RESULTS: The data analysis showed that postoperative bleeding with cyanoacrylate method was less significant than with suturing on the first and second day after surgery. There was no significant difference in the severity of pain between the two methods. CONCLUSION: This study suggested that the efficacy of both, cyanoacrylate and suturing in wound closure were similar in the severity of pain, but use of cyanoacrylate showed better hemostasis. FAU - Joshi, Ajit D AU - Joshi AD AD - Department of Oral and Maxillofacial Surgery, Darshan Dental College & Hospital, Loyara, 313 011 Udaipur, Rajasthan India. FAU - Saluja, Harish AU - Saluja H FAU - Mahindra, Uma AU - Mahindra U FAU - Halli, Rajshekhar AU - Halli R LA - eng PT - Journal Article DEP - 20110517 TA - J Maxillofac Oral Surg JT - Journal of maxillofacial and oral surgery JID - 101538309 PMC - PMC3267907 OTO - NOTNLM OT - Amcrylate OT - Hemostasis OT - Medicated tissue glue OT - Pain OT - Polymerization EDAT- 2012/12/04 06:00 MHDA- 2012/12/04 06:01 CRDT- 2012/12/04 06:00 PHST- 2010/01/16 00:00 [received] PHST- 2011/04/30 00:00 [accepted] PHST- 2012/12/04 06:00 [entrez] PHST- 2012/12/04 06:00 [pubmed] PHST- 2012/12/04 06:01 [medline] AID - 241 [pii] AID - 10.1007/s12663-011-0241-x [doi] PST - ppublish SO - J Maxillofac Oral Surg. 2011 Dec;10(4):310-5. doi: 10.1007/s12663-011-0241-x. Epub 2011 May 17. PMID- 26607842 OWN - NLM STAT- MEDLINE DCOM- 20160512 LR - 20181113 IS - 1746-160X (Electronic) IS - 1746-160X (Linking) VI - 11 DP - 2015 Nov 26 TI - Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: randomized multicenter split-mouth clinical trial. PG - 37 LID - 10.1186/s13005-015-0094-5 [doi] LID - 37 AB - BACKGROUND: Impacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery. METHODS: Fifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm. RESULTS: Horizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups. CONCLUSION: As a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery. FAU - Ozgul, Ozkan AU - Ozgul O AD - Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Ufuk University, Ankara, Turkey. ozkanozgul@yahoo.com. FAU - Senses, Fatma AU - Senses F AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey. FAU - Er, Nilay AU - Er N AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Trakya University, Edirne, Turkey. FAU - Tekin, Umut AU - Tekin U AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey. FAU - Tuz, Hakan Hıfzi AU - Tuz HH AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. FAU - Alkan, Alper AU - Alkan A AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri,, Turkey. FAU - Kocyigit, Ismail Doruk AU - Kocyigit ID AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey. FAU - Atil, Fethi AU - Atil F AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20151126 TA - Head Face Med JT - Head & face medicine JID - 101245792 RN - 9001-31-4 (Fibrin) SB - D SB - IM MH - Adolescent MH - Adult MH - Blood Platelets MH - Edema/*drug therapy/etiology MH - Female MH - Fibrin/*therapeutic use MH - Humans MH - Male MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*adverse effects MH - Tooth, Impacted/*surgery MH - Treatment Outcome MH - Young Adult PMC - PMC4660809 EDAT- 2015/11/27 06:00 MHDA- 2016/05/14 06:00 CRDT- 2015/11/27 06:00 PHST- 2015/05/21 00:00 [received] PHST- 2015/11/23 00:00 [accepted] PHST- 2015/11/27 06:00 [entrez] PHST- 2015/11/27 06:00 [pubmed] PHST- 2016/05/14 06:00 [medline] AID - 10.1186/s13005-015-0094-5 [pii] AID - 94 [pii] AID - 10.1186/s13005-015-0094-5 [doi] PST - epublish SO - Head Face Med. 2015 Nov 26;11:37. doi: 10.1186/s13005-015-0094-5. PMID- 17187035 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20070117 LR - 20061225 IS - 1462-0049 (Print) IS - 1462-0049 (Linking) VI - 7 IP - 4 DP - 2006 TI - Routine follow-up visits not necessary after third molar removal under sedation. PG - 92 AB - DESIGN: This was a randomised controlled trial (RCT) conducted in the US. INTERVENTION: People were recruited to the trial who required surgical removal of at least two impacted third molars under intravenous sedation on an outpatient basis. They were treated by board-certified oral and maxillofacial surgeons. Participants were divided randomly into two groups: the first was given a 2-week postoperative follow-up appointment, and the other had no follow-up. All patients received postoperative instructions and were contacted by telephone on the day after surgery. At 2 weeks postoperatively, all patients either returned to the clinic or were interviewed by telephone. OUTCOME MEASURE: Patients were asked to answer a questionnaire on postoperative day 1 and at 2 weeks after their treatment. The questionnaire was originally proposed by Worrall(1) but was modified for use in this study. RESULTS: Of the 60 consecutive patients who underwent third molar removal, only 48 were included. The mean age was 20 years (range, 15-33 years). There were no significant differences in the number of patients and gender between the groups receiving clinic or telephone follow-up. Seventy-three per cent (35 out of 48) out of all the patients preferred telephone follow-up, and 27% (13 out of 48) of patients preferred clinic follow-up. Eighty-five per cent (29 out of 34) of patients who did not have any complaints on postoperative day 1 preferred telephone follow-up (P<0.01). CONCLUSIONS: A routine follow-up visit following third molar removal under intravenous sedation is not necessary in patients aged between 15 and 35 years. Pre-operative and postoperative instructions should be clear, however. A selective review policy may be appropriate if a patient is mentally retarded, is taking psychoactive drugs, or has an intra-operative complications or a has made a complaint via telephone. FAU - Ainsworth, Gillian AU - Ainsworth G AD - Department of Oral Surgery, Glasgow Dental Hospital and School NHS Trust, Glasgow, Scotland, UK. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 CON - J Oral Maxillofac Surg. 2005 Sep;63(9):1278-82. PMID: 16122590 EDAT- 2006/12/26 09:00 MHDA- 2006/12/26 09:01 CRDT- 2006/12/26 09:00 PHST- 2006/12/26 09:00 [pubmed] PHST- 2006/12/26 09:01 [medline] PHST- 2006/12/26 09:00 [entrez] AID - 6400442 [pii] AID - 10.1038/sj.ebd.6400442 [doi] PST - ppublish SO - Evid Based Dent. 2006;7(4):92. doi: 10.1038/sj.ebd.6400442. PMID- 25737885 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150304 LR - 20201001 IS - 2212-4268 (Print) IS - 2212-4276 (Electronic) IS - 2212-4268 (Linking) VI - 3 IP - 2 DP - 2013 May-Aug TI - Laser vs bur for bone cutting in impacted mandibular third molar surgery: A randomized controlled trial. PG - 57-62 LID - 10.1016/j.jobcr.2013.03.006 [doi] AB - BACKGROUND: The aim of this study was to assess the feasibility of Er: YAG laser in bone cutting for removal of impacted lower third molar teeth and compare its outcomes with that of surgical bur. MATERIALS & METHODS: The study comprised 40 subjects requiring removal of impacted mandibular third molar, randomly categorized into two equal groups of 20 each, who had their impacted third molar removed either using Er: YAG laser or surgical bur as per their group, using standard methodology of extraction of impacted teeth. Clinical parameters like pain, bleeding, time taken for bone cutting, postoperative swelling, trismus, wound healing and complications were compared for both groups. OBSERVATION & RESULT: Clinical parameters like pain, bleeding and swelling were lower in laser group than bur group, although the difference was statistically not significant. However, postoperative swelling showed significant difference in the two groups. Laser group required almost double the time taken for bone cutting with bur. Trismus persisted for a longer period in laser group. Wound healing and complications were assessed clinically and there was no significant difference in both the groups. CONCLUSION: Based on the results of our study, the possibility of bone cutting using lasers is pursued, the osteotomy is easily performed and the technique is better suited to minimally invasive surgical procedures. The use of Er: YAG laser may be considered as an alternative tool to surgical bur, specially in anxious patients. FAU - Passi, Deepak AU - Passi D AD - Junior Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Pal, Uma Shankar AU - Pal US AD - Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Mohammad, Shadab AU - Mohammad S AD - Professor and Head, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Singh, Rakesh Kumar AU - Singh RK AD - Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Mehrotra, Divya AU - Mehrotra D AD - Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Singh, Geeta AU - Singh G AD - Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Kumar, Manoj AU - Kumar M AD - Assistant Professor, Department of Radiodiagnosis, King George's Medical University, India. FAU - Chellappa, Arul A L AU - Chellappa AA AD - Junior Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. FAU - Gupta, Chandan AU - Gupta C AD - Junior Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, India. LA - eng PT - Journal Article DEP - 20130406 TA - J Oral Biol Craniofac Res JT - Journal of oral biology and craniofacial research JID - 101619156 PMC - PMC3941831 OTO - NOTNLM OT - Bur technique OT - Impacted surgery OT - Laser bone cutting EDAT- 2013/05/01 00:00 MHDA- 2013/05/01 00:01 CRDT- 2015/03/05 06:00 PHST- 2013/02/10 00:00 [received] PHST- 2013/03/31 00:00 [accepted] PHST- 2015/03/05 06:00 [entrez] PHST- 2013/05/01 00:00 [pubmed] PHST- 2013/05/01 00:01 [medline] AID - S2212-4268(13)00030-4 [pii] AID - 10.1016/j.jobcr.2013.03.006 [doi] PST - ppublish SO - J Oral Biol Craniofac Res. 2013 May-Aug;3(2):57-62. doi: 10.1016/j.jobcr.2013.03.006. Epub 2013 Apr 6. PMID- 11936398 OWN - NLM STAT- MEDLINE DCOM- 20020703 LR - 20111117 IS - 0901-5027 (Print) IS - 0901-5027 (Linking) VI - 31 IP - 1 DP - 2002 Feb TI - External neurolysis of the lingual nerve. PG - 40-3 AB - The lingual nerve is sometimes injured during the surgical removal of an impacted mandibular third molar. The level of sensory recovery was studied in 10 patients who underwent external neurolysis of the lingual nerve. The mean time from third molar surgery to neurolysis was 13.5 months (range 9-24 months). Seven of the 10 patients showed significant improvement, three patients regaining normal sensation. Three patients showed no improvement. These results show that external neurolysis should be considered for patients with altered sensation in the distribution of the lingual nerve. FAU - Joshi, A AU - Joshi A AD - Department of Oral and Maxillofacial Surgery, Manchester Royal Infirmary, UK. FAU - Rood, J P AU - Rood JP LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - D SB - IM MH - Cranial Nerve Injuries/*surgery MH - Decompression, Surgical/*methods MH - Humans MH - Hypesthesia/etiology/surgery MH - Lingual Nerve/*surgery MH - *Lingual Nerve Injuries MH - Neurosurgical Procedures/*methods MH - Tooth Extraction/adverse effects MH - Treatment Outcome EDAT- 2002/04/09 10:00 MHDA- 2002/07/04 10:01 CRDT- 2002/04/09 10:00 PHST- 2002/04/09 10:00 [pubmed] PHST- 2002/07/04 10:01 [medline] PHST- 2002/04/09 10:00 [entrez] AID - S0901-5027(01)90156-0 [pii] AID - 10.1054/ijom.2001.0156 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2002 Feb;31(1):40-3. doi: 10.1054/ijom.2001.0156. PMID- 26212090 OWN - NLM STAT- MEDLINE DCOM- 20160118 LR - 20151016 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 73 IP - 11 DP - 2015 Nov TI - Effect of Audiovisual Treatment Information on Relieving Anxiety in Patients Undergoing Impacted Mandibular Third Molar Removal. PG - 2087-92 LID - S0278-2391(15)00912-X [pii] LID - 10.1016/j.joms.2015.06.175 [doi] AB - PURPOSE: The authors hypothesized that an audiovisual slide presentation that provided treatment information regarding the removal of an impacted mandibular third molar could improve patient knowledge of postoperative complications and decrease anxiety in young adults before and after surgery. A group that received an audiovisual description was compared with a group that received the conventional written description of the procedure. MATERIALS AND METHODS: This randomized clinical trial included young adult patients who required surgical removal of an impacted mandibular third molar and fulfilled the predetermined criteria. The predictor variable was the presentation of an audiovisual slideshow. The audiovisual informed group provided informed consent after viewing an audiovisual slideshow. The control group provided informed consent after reading a written description of the procedure. The outcome variables were the State-Trait Anxiety Inventory, the Dental Anxiety Scale, a self-reported anxiety questionnaire, completed immediately before and 1 week after surgery, and a postoperative questionnaire about the level of understanding of potential postoperative complications. The data were analyzed with χ(2) tests, independent t tests, Mann-Whitney U  tests, and Spearman rank correlation coefficients. RESULTS: Fifty-one patients fulfilled the inclusion criteria. The audiovisual informed group was comprised of 20 men and 5 women; the written informed group was comprised of 21 men and 5 women. The audiovisual informed group remembered significantly more information than the control group about a potential allergic reaction to local anesthesia or medication and potential trismus (P < .05). The audiovisual informed group had lower self-reported anxiety scores than the control group 1 week after surgery (P < .05). CONCLUSION: These results suggested that informing patients of the treatment with an audiovisual slide presentation could improve patient knowledge about postoperative complications and aid in alleviating anxiety after the surgical removal of an impacted mandibular third molar. CI - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Choi, Sung-Hwan AU - Choi SH AD - Fellow, Department of Orthodontics, College of Dentistry, Yonsei University, Seoul, Korea. FAU - Won, Ji-Hoon AU - Won JH AD - Postgraduate Student, Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea. FAU - Cha, Jung-Yul AU - Cha JY AD - Associate Professor, Department of Orthodontics, The Institute of Cranial-Facial Deformity, College of Dentistry, Yonsei University, Seoul, Korea. FAU - Hwang, Chung-Ju AU - Hwang CJ AD - Professor, Department of Orthodontics, The Institute of Cranial-Facial Deformity, College of Dentistry, Yonsei University, Seoul, Korea. Electronic address: hwang@yuhs.ac. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20150708 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM MH - Adult MH - Anxiety/etiology/*prevention & control MH - *Audiovisual Aids MH - Female MH - Humans MH - Male MH - Mandible/*surgery MH - Prospective Studies MH - Tooth Extraction/*psychology MH - *Tooth, Impacted MH - Young Adult EDAT- 2015/07/28 06:00 MHDA- 2016/01/19 06:00 CRDT- 2015/07/28 06:00 PHST- 2015/03/20 00:00 [received] PHST- 2015/05/13 00:00 [revised] PHST- 2015/06/25 00:00 [accepted] PHST- 2015/07/28 06:00 [entrez] PHST- 2015/07/28 06:00 [pubmed] PHST- 2016/01/19 06:00 [medline] AID - S0278-2391(15)00912-X [pii] AID - 10.1016/j.joms.2015.06.175 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2015 Nov;73(11):2087-92. doi: 10.1016/j.joms.2015.06.175. Epub 2015 Jul 8. PMID- 29913883 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 1877-8879 (Electronic) IS - 1877-8860 (Linking) VI - 4 IP - 1 DP - 2013 Jan 1 TI - Evaluation of the analgesic efficacy of AZD1940, a novel cannabinoid agonist, on post-operative pain after lower third molar surgical removal. PG - 17-22 LID - /j/sjpain.2013.4.issue-1/j.sjpain.2012.08.004/j.sjpain.2012.08.004.xml [pii] LID - 10.1016/j.sjpain.2012.08.004 [doi] AB - Aim To evaluate the analgesic efficacy of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, in patients undergoing third molar surgical removal. Methods This was a randomized, double-blind, placebo-controlled study in patients scheduled for surgical removal of an impacted lower third molar. Patients received a single oral dose of 800 μg AZD1940, 500 mg naproxen or placebo 1.5 h before surgery. The dose of 800 μg AZD1940 was selected based on earlier data from a single dose study in man, in which it was identified as the highest well tolerated dose. Ongoing post-operative pain (primary variable) and pain on jaw movement were assessed on a visual analog scale (VAS, 0-100 mm) from 0 to 8h postoperatively, deriving the area under the curve of ongoing pain (VAS AUC0-8h), and of pain on jaw movement (VASJM AUC0-8h). The time to requesting rescue medication (acetaminophen) was recorded. Subjective cannabinoid effects were assessed by the visual analog mood scale (VAMS). Results In total, 151 patients were randomized to AZD1940 (n = 61), placebo (n = 59) or naproxen (n = 31). There was no statistically significant difference in pain VAS AUC0-8h or in VASJM AUC0-8h between AZD1940 and placebo. Naproxen significantly reduced both pain VAS AUC0-8h and VASJM AUC0-8h as compared with placebo (p < 0.0001 for both). Significantly fewer patients on naproxen requested rescue medication and the duration of time to rescue was greater, as compared with placebo, whereas there were no significant differences between AZD1940 and placebo in these outcome variables. Statistically significant increases in VAMS items "sedated" and "high" were observed after AZD1940 compared with placebo. The increases in VAMS were numerically small compared with previous findings with a centrally acting cannabinoid. The most commonly observed adverse events (AE) on treatment with AZD1940 were postural dizziness (80% of subjects), nausea (26%), hypotension (21%) and headache (13%), most AE being mild to moderate. Conclusion The CB1/CB2 receptor agonist AZD1940 did not reduce post-operative pain after lower third molar surgical removal at doses exerting subjective cannabinoid effects. Implications Activation of peripheral CB1/CB2 receptors per se is probably of less clinical relevance for the treatment of acute nociceptive pain in man. FAU - Kalliomäki, Jarkko AU - Kalliomäki J AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. FAU - Segerdahl, Märta AU - Segerdahl M AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. FAU - Webster, Lynn AU - Webster L AD - Lifetree Clinical Research, 3838 South, 700 East, Suite 202, Salt Lake City, UT 84106, USA. FAU - Reimfelt, Annika AU - Reimfelt A AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. FAU - Huizar, Karin AU - Huizar K AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. FAU - Annas, Peter AU - Annas P AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. FAU - Karlsten, Rolf AU - Karlsten R AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. FAU - Quiding, Hans AU - Quiding H AD - AstraZeneca R&D Södertälje, Södertälje, Sweden. LA - eng PT - Journal Article DEP - 20130101 PL - Germany TA - Scand J Pain JT - Scandinavian journal of pain JID - 101520867 OTO - NOTNLM OT - Cannabinoid OT - Clinical trial OT - Dental extraction OT - Dental pain OT - Post-operative pain OT - Tooth extraction EDAT- 2018/06/20 06:00 MHDA- 2018/06/20 06:01 CRDT- 2018/06/20 06:00 PHST- 2012/06/26 00:00 [received] PHST- 2012/08/24 00:00 [accepted] PHST- 2018/06/20 06:00 [entrez] PHST- 2018/06/20 06:00 [pubmed] PHST- 2018/06/20 06:01 [medline] AID - /j/sjpain.2013.4.issue-1/j.sjpain.2012.08.004/j.sjpain.2012.08.004.xml [pii] AID - 10.1016/j.sjpain.2012.08.004 [doi] PST - epublish SO - Scand J Pain. 2013 Jan 1;4(1):17-22. doi: 10.1016/j.sjpain.2012.08.004. PMID- 32760476 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2029-283X (Print) IS - 2029-283X (Electronic) IS - 2029-283X (Linking) VI - 11 IP - 2 DP - 2020 Apr-Jun TI - Short-term Haematological Parameters Following Surgical Removal of Mandibular Third Molars with Different Doses of Methylprednisolone Compared with Placebo. A Randomized Controlled Trial. PG - e3 LID - 10.5037/jomr.2020.11203 [doi] LID - e3 AB - OBJECTIVES: To evaluate the influence of a single intraoperative injection of methylprednisolone on short-term haematological parameters following surgical removal of mandibular third molars. MATERIAL AND METHODS: Fifty-two patients with indications for surgical removal of bilateral impacted mandibular third molars were included in a randomized, split-mouth and double-blinded study design. Each molar were randomly allocated into one of following four groups: 20 mg methylprednisolone, 30 mg methylprednisolone, 40 mg methylprednisolone and placebo. Peripheral blood samples were obtained before and three days after surgery. Haematological parameters involving haemoglobin, white blood cell count and C-reactive protein (CRP) were evaluated and expressed as mean changes. Level of significance was 0.05. Furthermore, outcomes were correlated for age, sex, smoking and time of surgery. RESULTS: There were no significant differences in postoperative haematological parameters with different doses of methylprednisolone compared with placebo. Peripheral blood samples revealed decreased level of haemoglobin and increased level of leucocytes and CRP in each group. Smokers displayed a significant lower level of haemoglobin and CRP compared with non-smokers (P < 0.05) and level of eosinophils decreased significantly with increasing age (P < 0.05). CONCLUSIONS: This study indicates that a single intraoperative injection of methylprednisolone seems not to cause suppression of short-term haematological parameters compared with placebo following surgical removal of mandibular third molars. CI - Copyright © Larsen MK, Kofod T, Kirsten D, Starch-Jensen T. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 30 June 2020. FAU - Larsen, Marie Kjærgaard AU - Larsen MK AD - Department of Oral and Maxillofacial Surgery, Aalborg University HospitalDenmark. FAU - Kofod, Thomas AU - Kofod T AD - Department of Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen University HospitalDenmark. FAU - Duch, Kirsten AU - Duch K AD - Clinical unit of Biostatistics, Aalborg University Hospital, AalborgDenmark. FAU - Starch-Jensen, Thomas AU - Starch-Jensen T AD - Department of Oral and Maxillofacial Surgery, Aalborg University HospitalDenmark. LA - eng PT - Journal Article DEP - 20200630 TA - J Oral Maxillofac Res JT - Journal of oral & maxillofacial research JID - 101552108 PMC - PMC7393928 OTO - NOTNLM OT - C-reactive protein OT - corticosteroids OT - leucocytes OT - mandible OT - methylprednisolone OT - third molar EDAT- 2020/08/08 06:00 MHDA- 2020/08/08 06:01 CRDT- 2020/08/08 06:00 PHST- 2020/03/25 00:00 [received] PHST- 2020/06/11 00:00 [accepted] PHST- 2020/08/08 06:00 [entrez] PHST- 2020/08/08 06:00 [pubmed] PHST- 2020/08/08 06:01 [medline] AID - v11n2e3ht [pii] AID - 10.5037/jomr.2020.11203 [doi] PST - epublish SO - J Oral Maxillofac Res. 2020 Jun 30;11(2):e3. doi: 10.5037/jomr.2020.11203. eCollection 2020 Apr-Jun. PMID- 26675081 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20151217 LR - 20201001 IS - 2249-782X (Print) IS - 0973-709X (Electronic) IS - 0973-709X (Linking) VI - 9 IP - 11 DP - 2015 Nov TI - Randomized Controlled Trial to Evaluate the Efficacy of Oral Dexamethasone and Intramuscular Dexamethasone in Mandibular Third Molar Surgeries. PG - ZC48-51 LID - 10.7860/JCDR/2015/13930.6813 [doi] AB - INTRODUCTION: Surgical removal of impacted third molar is the most commonly performed dento-alveolar procedure and is associated with post-operative pain, swelling and trismus. AIM: The aim of the study was to compare the efficacy of dexamethasone administered orally with that of dexamethasone administered as an intra-masseteric injection in surgical removal of mandibular third molars. MATERIALS AND METHODS: Sixty patients with impacted mandibular third molars were selected to undergo surgical removal of mandibular third molars. They were divided into three groups of twenty each, viz., Control Group, Group taking Oral dexamethasone and Group taking Intra-masseteric dexamethasone. Evaluation was done over a period of seven days postoperatively to study the effects of the drug in terms of swelling, trismus and pain. RESULTS: ANOVA test was done and comparisons were made. It was found that there was a statistically significant difference with respect to the group taking oral dexamethasone in terms of resolution of trismus. It was also found that there was no statistical significance with respect to reduction in swelling in either of the groups. CONCLUSION: Thus, it can be concluded that the oral route is superior compared to the intramuscular route when administering dexamethasone in surgical removal of mandibular third molars, with respect to drug dosage, bio-availability and resolution of trismus. FAU - Sabhlok, Samrat AU - Sabhlok S AD - Reader, Department of Oral and Maxillofacial Surgery, Dr D.Y. Patil Dental College and Hospital , Pune, Maharashtra, India . FAU - Kenjale, Prachi AU - Kenjale P AD - Dental Surgeon, Mumbai, Maharashtra, India . FAU - Mony, Deepthi AU - Mony D AD - Consultant, Oral and Maxillofacial Surgery, Navi Mumbai, Maharashtra, India . FAU - Khatri, Isha AU - Khatri I AD - Consultant, Department of Oral and Maxillofacial Radiology, Dashabhuja CBCT Centre , Pune, Maharshtra, India . FAU - Kumar, Pratiksha AU - Kumar P AD - Assistant Professor, Department of Oral Pathology, Government Dental College , Indore, Madhya Pradesh, India . LA - eng PT - Journal Article DEP - 20151101 TA - J Clin Diagn Res JT - Journal of clinical and diagnostic research : JCDR JID - 101488993 PMC - PMC4668523 OTO - NOTNLM OT - Corticosteroids OT - Intra-massetric injection OT - Trismus EDAT- 2015/12/18 06:00 MHDA- 2015/12/18 06:01 CRDT- 2015/12/18 06:00 PHST- 2015/03/10 00:00 [received] PHST- 2015/08/28 00:00 [accepted] PHST- 2015/12/18 06:00 [entrez] PHST- 2015/12/18 06:00 [pubmed] PHST- 2015/12/18 06:01 [medline] AID - 10.7860/JCDR/2015/13930.6813 [doi] PST - ppublish SO - J Clin Diagn Res. 2015 Nov;9(11):ZC48-51. doi: 10.7860/JCDR/2015/13930.6813. Epub 2015 Nov 1. PMID- 26981470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160316 LR - 20201001 IS - 2231-0746 (Print) IS - 2249-3816 (Electronic) IS - 2231-0746 (Linking) VI - 5 IP - 2 DP - 2015 Jul-Dec TI - Evaluation of inorganic bovine bone graft in periodontal defects after third molar surgery. PG - 198-202 LID - 10.4103/2231-0746.175765 [doi] AB - AIM: This study evaluated the e cacy of inorganic bovine bone graft (IBB) in periodontal defect after mandibular third molar (3M) surgery. METHODS: The authors conducted a split-mouth, prospective, randomized, blinded, placebo-controlled clinical trial involving 20 participants with a mean age of 21.60 ± 6.5 years who had symmetrical bilateral lower 3M randomly assigned to receive IBB or left empty (blooding clot). The clinical variables studied were probing depth and clinical attachment level (CAL) at preoperative and postoperative periods of 10, 30, and 60 days. Radiographic measures included the distance from the alveolar bone crest to the cementoenamel junction and the bone density at 30 and 60 days postsurgical procedure. For statistical analysis, we used the paired t-test at a level of signi cance of 5%. RESULTS: It was observed a reduction in pocket depth and CAL in both groups, but IBB did not provide better results than blooding clot (P > 0.05). On the other hand, IBB group showed an increased in the bone density, and a decrease in the periodontal defect on the distal surface of second molar (2M) after 30 and 60 days of surgery compared to the control group (P < 0.05). CONCLUSION: The use of inorganic bone graft (GenOx) did not enhance the probing depth after 3M removal. Although the radiographic ndings have showed an increase in bone density and a decrease in the periodontal defect on the distal surface of the 2M, we cannot recommend the use of IBB as a treatment for periodontal defect prevention after 3M removal. FAU - de Melo, Daniela Guimaraes AU - de Melo DG AD - Department of Oral and Maxillofacial Surgery, Pernambuco Dental School, University of Pernambuco, Pernambuco, Brazil. FAU - de Santana Santos, Thiago AU - de Santana Santos T AD - Department of Dentistry, Federal University of Sergipe, Sergipe, Brazil. FAU - Sehn, Felipe Perraro AU - Sehn FP AD - Department of Dentistry, Federal University of Pernambuco, Pernambuco, Brazil. FAU - de Oliveira E Silva, Emanuel Dias AU - de Oliveira E Silva ED AD - Department of Oral and Maxillofacial Surgery, Pernambuco Dental School, University of Pernambuco, Pernambuco, Brazil. FAU - Martins-Filho, Paulo Ricardo Saquete AU - Martins-Filho PR AD - Department of Health Education, Federal University of Sergipe, Sergipe, Brazil. FAU - Dourado, Ana Cláudia Amorim Gomes AU - Dourado AC AD - Department of Oral and Maxillofacial Surgery, Pernambuco Dental School, University of Pernambuco, Pernambuco, Brazil. LA - eng PT - Journal Article TA - Ann Maxillofac Surg JT - Annals of maxillofacial surgery JID - 101598423 PMC - PMC4772560 OTO - NOTNLM OT - Attachment loss OT - bone density OT - bovine bone mineral OT - periodontal defect OT - third molar EDAT- 2016/03/17 06:00 MHDA- 2016/03/17 06:01 CRDT- 2016/03/17 06:00 PHST- 2016/03/17 06:00 [entrez] PHST- 2016/03/17 06:00 [pubmed] PHST- 2016/03/17 06:01 [medline] AID - AMS-5-198 [pii] AID - 10.4103/2231-0746.175765 [doi] PST - ppublish SO - Ann Maxillofac Surg. 2015 Jul-Dec;5(2):198-202. doi: 10.4103/2231-0746.175765. PMID- 30637344 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2383-9309 (Print) IS - 2383-9317 (Electronic) IS - 2383-9309 (Linking) VI - 18 IP - 6 DP - 2018 Dec TI - Inferior alveolar nerve block by intraosseous injection with Quicksleeper® at the retromolar area in mandibular third molar surgery. PG - 339-347 LID - 10.17245/jdapm.2018.18.6.339 [doi] AB - BACKGROUND: There are many techniques of inferior alveolar nerve block injection (IANBI); one among them is the computer-assisted intraosseous injection (CAIOI). Here we aim to evaluate the effectiveness of CAIOI with Quicksleeper® in mandibular third molar surgery. METHODS: This study is a clinical, single-blind, randomized, split-mouth, controlled trial including 25 patients (10 males and 15 females, mean age 21 years). The patients underwent surgical removal of bilateral mandibular third molars with two different IANBI techniques. One side was injected using Quicksleeper®, and the other side was injected using a conventional IANBI. Both techniques used one cartridge (1.7 ml) of 1:100,000 epinephrine 4% articaine. A supplementary injection was used if necessary. All volumes of anesthetic agent used were recorded. Statistical analysis was performed using paired t-test and Wilcoxon test. RESULTS: This research showed that CAIOI has faster onset and shorter duration of action than IANBI (P < 0.05). The pain was similar in both techniques. In the CAIOI group, one-third of the cases could be completed without additional anesthesia. The remaining two-thirds required minimal supplementary volume of anesthesia. The success rates were 68% for CAIOI and 72% for IANBI, respectively. CONCLUSION: CAIOI is an advantageous anesthetic technique. It can be used as an alternative to conventional IANBI for mandibular third molar surgery. FAU - Sovatdy, Sam AU - Sovatdy S AUID- ORCID: 0000-0002-6564-5067 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Vorakulpipat, Chakorn AU - Vorakulpipat C AUID- ORCID: 0000-0001-6627-8732 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Kiattavorncharoen, Sirichai AU - Kiattavorncharoen S AUID- ORCID: 0000-0001-6766-9188 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Saengsirinavin, Chavengkiat AU - Saengsirinavin C AUID- ORCID: 0000-0003-1344-5036 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Wongsirichat, Natthamet AU - Wongsirichat N AUID- ORCID: 0000-0003-3005-2680 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20181228 TA - J Dent Anesth Pain Med JT - Journal of dental anesthesia and pain medicine JID - 101690691 PMC - PMC6323038 OTO - NOTNLM OT - Articaine OT - Computer-assisted Intraosseous Injection OT - Inferior Alveolar Nerve Block OT - Mandible OT - Quicksleeper® OT - Third Molar Surgery COIS- CONFLICT OF INTEREST: The authors in this study have no conflict of interest. EDAT- 2019/01/15 06:00 MHDA- 2019/01/15 06:01 CRDT- 2019/01/15 06:00 PHST- 2018/10/14 00:00 [received] PHST- 2018/11/09 00:00 [revised] PHST- 2018/11/15 00:00 [accepted] PHST- 2019/01/15 06:00 [entrez] PHST- 2019/01/15 06:00 [pubmed] PHST- 2019/01/15 06:01 [medline] AID - 10.17245/jdapm.2018.18.6.339 [doi] PST - ppublish SO - J Dent Anesth Pain Med. 2018 Dec;18(6):339-347. doi: 10.17245/jdapm.2018.18.6.339. Epub 2018 Dec 28. PMID- 18991469 OWN - NLM STAT- MEDLINE DCOM- 20090127 LR - 20191111 IS - 1173-2563 (Print) IS - 1173-2563 (Linking) VI - 28 IP - 12 DP - 2008 TI - Analgesic efficacy of quick-release versus standard lornoxicam for pain after third molar surgery: a randomized, double-blind, placebo-controlled, single-dose trial. PG - 757-66 LID - 10.2165/0044011-200828120-00003 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the analgesic efficacy and time to onset of effect of the lornoxicam quick-release (LNX-QR) tablet compared with the standard-release tablet (LNX-ST). METHODS: In this randomized, double-blind, single-dose trial, 200 patients with moderate pain after surgical removal of an impacted third molar were randomized to treatment with an LNX-QR 8 mg tablet (80 patients), an LNX-ST 8 mg tablet (80 patients) or placebo (40 patients). Pain intensity (PI) and pain relief (PAR) were assessed (numerical and verbal rating scales) for 6 hours, and time to onset of PAR was recorded. The cumulated sum of PI differences (SPID) and PAR (TOTPAR) were calculated. Tolerability was evaluated by occurrence of adverse events. RESULTS: Kaplan-Meier analysis of time to onset of analgesic efficacy demonstrated a significantly faster onset with LNX-QR than placebo or LNX-ST (p < 0.0001). Median time of onset was 32 minutes (range 29-37) for LNX-QR and 46 minutes (range 37-59) for LNX-ST. The analgesic efficacy of LNX-QR and LNX-ST were superior to that of placebo, whereas paired comparisons of TOTPAR and SPID showed LNX-QR to be superior to LNX-ST (p < 0.05). CONCLUSION: LNX-QR provided a faster onset and superior analgesic effect against pain following third molar surgery than LNX-ST. FAU - Møller, Philip L AU - Møller PL AD - Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. FAU - Nørholt, Sven E AU - Nørholt SE LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - New Zealand TA - Clin Drug Investig JT - Clinical drug investigation JID - 9504817 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - ER09126G7A (lornoxicam) SB - IM MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar/*surgery MH - Pain, Postoperative/*drug therapy MH - Piroxicam/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use EDAT- 2008/11/11 09:00 MHDA- 2009/01/28 09:00 CRDT- 2008/11/11 09:00 PHST- 2008/11/11 09:00 [pubmed] PHST- 2009/01/28 09:00 [medline] PHST- 2008/11/11 09:00 [entrez] AID - 28123 [pii] AID - 10.2165/0044011-200828120-00003 [doi] PST - ppublish SO - Clin Drug Investig. 2008;28(12):757-66. doi: 10.2165/0044011-200828120-00003. PMID- 30895143 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2213-8862 (Electronic) IS - 1991-7902 (Print) IS - 1991-7902 (Linking) VI - 13 IP - 4 DP - 2018 Dec TI - Piezosurgery vs conventional rotary instrument in the third molar surgery: A systematic review and meta-analysis of randomized controlled trials. PG - 342-349 LID - 10.1016/j.jds.2016.09.006 [doi] AB - BACKGROUND/PURPOSE: The surgical removal of mandibular third molars is frequently accompanied by significant postsurgical sequelae. Different instruments such as piezosurgery and conventional rotary handpiece have been used to decrease such adverse events. There are controversial results from randomized controlled trials evaluating the effects of Piezosurgery in the mandibular third molar extraction, compared with conventional rotary instrument. This study was performed to determine the impact of piezosurgery versus conventional rotary instrument on postoperative reactions after extraction. MATERIALS AND METHODS: A systematic review and meta-analysis was performed to combine relevant RCTs results. RESULTS: Five RCTs were eligible for this study, enrolling a total of 402 patients. Compared with conventional rotary instrument, pain score at 6 or 7 days and mouth opening at 1 day after surgery was significantly lower in Piezosurgery group (SMD -0.33, 95% CI: -0.56 to -0.10, P = 0.005), as well as swelling score at 7 days after surgery (SMD -1.95, 95% CI: -3.22 to -0.67, P = 0.003). Furthermore, mouth opening at 1 day after surgery was significantly better in patients treated with Piezosurgery (SMD 0.84, 95% CI: 0.19 to 1.49, P = 0.01). However, more operation time will be required for Piezosurgery (MD 6.23, 95% CI: 3.32 to 9.14, P < 0.0001). With regard to analgesic dosage, pooled results from two RCTs suggested there were no significant differences between Piezosurgery and conventional rotary instrument (SMD -1.45, 95% CI: -4.39 to 1.49, P = 0.33). CONCLUSION: There might be some advantages on third mandibular molar extraction with piezosurgery compared to conventional rotary instrument. More multi-centre trials are required to get more conclusive results. FAU - Liu, Jiyuan AU - Liu J AD - State Key Laboratory of Oral Diseases, China. FAU - Hua, Chengge AU - Hua C AD - State Key Laboratory of Oral Diseases, China. FAU - Pan, Jian AU - Pan J AD - State Key Laboratory of Oral Diseases, China. FAU - Han, Bo AU - Han B AD - State Key Laboratory of Oral Diseases, China. FAU - Tang, Xiufa AU - Tang X AD - State Key Laboratory of Oral Diseases, China. LA - eng PT - Journal Article PT - Review DEP - 20180804 TA - J Dent Sci JT - Journal of dental sciences JID - 101293181 PMC - PMC6388871 OTO - NOTNLM OT - Conventional rotary instrument OT - Oral surgery OT - Piezosurgery EDAT- 2019/03/22 06:00 MHDA- 2019/03/22 06:01 CRDT- 2019/03/22 06:00 PHST- 2015/12/18 00:00 [received] PHST- 2016/07/22 00:00 [revised] PHST- 2016/09/13 00:00 [accepted] PHST- 2019/03/22 06:00 [entrez] PHST- 2019/03/22 06:00 [pubmed] PHST- 2019/03/22 06:01 [medline] AID - S1991-7902(18)30617-2 [pii] AID - 10.1016/j.jds.2016.09.006 [doi] PST - ppublish SO - J Dent Sci. 2018 Dec;13(4):342-349. doi: 10.1016/j.jds.2016.09.006. Epub 2018 Aug 4. PMID- 2726279 OWN - NLM STAT- MEDLINE DCOM- 19890623 LR - 20210112 IS - 0304-3959 (Print) IS - 0304-3959 (Linking) VI - 37 IP - 1 DP - 1989 Apr TI - Codeine 20 mg increases pain relief from ibuprofen 400 mg after third molar surgery. A repeat-dosing comparison of ibuprofen and an ibuprofen-codeine combination. PG - 7-13 LID - 10.1016/0304-3959(89)90147-4 [doi] AB - A combination of 20 mg codeine base and ibuprofen 400 mg was compared with ibuprofen 400 mg in a randomised double-blind cross-over study of multiple doses in 25 patients after 2-stage bilateral third molar removal. The combination produced significantly greater pain relief and doubled the hours of minimum pain intensity and maximal relief on the day of surgery. The patients rated the combination significantly better than ibuprofen alone, and the combination was preferred by 16 of the 22 patients expressing a preference. There was no significant increase in side-effect incidence with the combination. The 30% increase in analgesic effect may be of clinical benefit, and this trial design, cross-over with multiple dosing in out-patients, may be a sensitive test for analgesics, potentially more predictive of side-effect problems than single-dose studies. FAU - McQuay, H J AU - McQuay HJ AD - Oral Surgery Department, John Radcliffe Hospital, Headington, OxfordU.K. Oxford Regional Pain Relief Unit, Abingdon Hospital, Abingdon, OxfordU.K. FAU - Carroll, D AU - Carroll D FAU - Watts, P G AU - Watts PG FAU - Juniper, R P AU - Juniper RP FAU - Moore, R A AU - Moore RA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (Drug Combinations) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - IM EIN - Pain 1989 Dec;39(3):373 MH - Adult MH - Codeine/*therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/*therapeutic use MH - Male MH - Molar/*surgery MH - Pain/*drug therapy EDAT- 1989/04/01 00:00 MHDA- 1989/04/01 00:01 CRDT- 1989/04/01 00:00 PHST- 1989/04/01 00:00 [pubmed] PHST- 1989/04/01 00:01 [medline] PHST- 1989/04/01 00:00 [entrez] AID - 00006396-198904000-00002 [pii] AID - 10.1016/0304-3959(89)90147-4 [doi] PST - ppublish SO - Pain. 1989 Apr;37(1):7-13. doi: 10.1016/0304-3959(89)90147-4. PMID- 24608204 OWN - NLM STAT- MEDLINE DCOM- 20150406 LR - 20190608 IS - 1698-6946 (Electronic) IS - 1698-4447 (Print) IS - 1698-4447 (Linking) VI - 19 IP - 4 DP - 2014 Jul 1 TI - Efficacy and complications associated with a modified inferior alveolar nerve block technique. A randomized, triple-blind clinical trial. PG - e391-7 AB - OBJECTIVE: To compare the efficacy and complication rates of two different techniques for inferior alveolar nerve blocks (IANB). STUDY DESIGN: A randomized, triple-blind clinical trial comprising 109 patients who required lower third molar removal was performed. In the control group, all patients received an IANB using the conventional Halsted technique, whereas in the experimental group, a modified technique using a more inferior injection point was performed. RESULTS: A total of 100 patients were randomized. The modified technique group showed a significantly higher onset time in the lower lip and chin area, and was frequently associated to a lingual electric discharge sensation. Three failures were recorded, 2 of them in the experimental group. No relevant local or systemic complications were registered. CONCLUSIONS: Both IANB techniques used in this trial are suitable for lower third molar removal. However, performing an inferior alveolar nerve block in a more inferior position (modified technique) extends the onset time, does not seem to reduce the risk of intravascular injections and might increase the risk of lingual nerve injuries. FAU - Montserrat-Bosch, Marta AU - Montserrat-Bosch M AD - Faculty of Dentistry - University of Barcelona, Campus de Bellvitge, Facultat d`Odontologia, Cirugía e Implantología Bucal, C/ Feixa Llarga, s/n; Pavelló Govern, 2 planta, Despatx 2.9, 08907 L'Hospitalet de Llobregat, Barcelona, Spain, rui@ruibf.com. FAU - Figueiredo, Rui AU - Figueiredo R FAU - Nogueira-Magalhães, Pedro AU - Nogueira-Magalhães P FAU - Arnabat-Dominguez, Josep AU - Arnabat-Dominguez J FAU - Valmaseda-Castellón, Eduard AU - Valmaseda-Castellón E FAU - Gay-Escoda, Cosme AU - Gay-Escoda C LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140701 TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 SB - D SB - IM MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - *Mandibular Nerve MH - Molar/*surgery MH - Nerve Block/*adverse effects/*methods MH - *Tooth Extraction MH - Treatment Outcome PMC - PMC4119316 COIS- Conflict of interest statement: The authors have declared that no conflict of interest exist. EDAT- 2014/03/13 06:00 MHDA- 2015/04/07 06:00 CRDT- 2014/03/11 06:00 PHST- 2013/09/18 00:00 [received] PHST- 2013/12/18 00:00 [accepted] PHST- 2014/03/11 06:00 [entrez] PHST- 2014/03/13 06:00 [pubmed] PHST- 2015/04/07 06:00 [medline] AID - 19554 [pii] AID - 10.4317/medoral.19554 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2014 Jul 1;19(4):e391-7. doi: 10.4317/medoral.19554. PMID- 33557388 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210303 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 10 IP - 4 DP - 2021 Feb 4 TI - Flapless Surgical Approach to Extract Impacted Inferior Third Molars: A Retrospective Clinical Study. LID - 10.3390/jcm10040593 [doi] LID - 593 AB - This study aimed to compare a flapless surgical approach (FSA) with a traditional envelope flap (traditional approach (TA)). Every patient was treated with two approaches: TA and FSA. The primary outcome variables were both the discomfort during the post-operative convalescence and the correct final recovery of the impacted area. The secondary outcome variable was the average duration of the surgery. Post-operative pain and oedema were recorded. The measurements of soft tissue interface toward the distobuccal edge of the second molar were taken by periodontal probe before surgery (baseline) and 8 weeks after surgery. Statistical software was used to evaluate the data; a p-value < 0.05 was considered statistically significant. Twenty-four teeth of 12 patients (six Caucasian males and six Caucasian females, aged 23 ± 4 (17-30) years) with both lower impacted third molars (Ms3) were analysed. Considering an alpha error 0.05 that sample size allows power from 0.80 to 0.90, depending on the variable evaluated. Concerning attached gingiva, oedema and pain, the linear mixed model resulted in a statistically significant difference between the TA and FSA (p = 0.003; p < 0.01; and p = 0.018, respectively). Conversely, the model did not show a difference (p = 0.322) if pocket probing depth was considered. The FSA procedure was faster (p < 0.05) than the TA procedure (17 min and 8 s (±6 s) vs. 28 min and 6 s (±4 s), respectively). The results suggest that the FSA could be a suitable option for improving the surgical removal of lower Ms3. However, additional randomized controlled trial studies are necessary to confirm the reliability of our procedure and to verify its suitability in more complex Ms3 classifications. FAU - Materni, Alberto AU - Materni A AUID- ORCID: 0000-0002-3944-2848 AD - Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genova, 16132 Genova, Italy. FAU - De Angelis, Nicola AU - De Angelis N AD - Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genova, 16132 Genova, Italy. FAU - Di Tullio, Nicolò AU - Di Tullio N AUID- ORCID: 0000-0002-3617-2993 AD - Department of Health Science (DISSAL), University of Genova, 16132 Genova, Italy. FAU - Colombo, Esteban AU - Colombo E AUID- ORCID: 0000-0003-3984-2830 AD - Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genova, 16132 Genova, Italy. FAU - Benedicenti, Stefano AU - Benedicenti S AD - Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genova, 16132 Genova, Italy. FAU - Amaroli, Andrea AU - Amaroli A AUID- ORCID: 0000-0002-0494-7942 AD - Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genova, 16132 Genova, Italy. AD - Faculty of Dentistry, Department of Orthopaedic Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia. LA - eng PT - Journal Article DEP - 20210204 TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC7914559 OTO - NOTNLM OT - flap design OT - impacted tooth OT - mandibular molar OT - oral surgery OT - third molar extraction OT - third molar surgery COIS- The authors declare no conflict of interest. EDAT- 2021/02/10 06:00 MHDA- 2021/02/10 06:01 CRDT- 2021/02/09 01:03 PHST- 2021/01/07 00:00 [received] PHST- 2021/01/21 00:00 [revised] PHST- 2021/02/01 00:00 [accepted] PHST- 2021/02/09 01:03 [entrez] PHST- 2021/02/10 06:00 [pubmed] PHST- 2021/02/10 06:01 [medline] AID - jcm10040593 [pii] AID - jcm-10-00593 [pii] AID - 10.3390/jcm10040593 [doi] PST - epublish SO - J Clin Med. 2021 Feb 4;10(4):593. doi: 10.3390/jcm10040593. PMID- 20173715 OWN - NLM STAT- MEDLINE DCOM- 20101202 LR - 20190608 IS - 1698-6946 (Electronic) IS - 1698-4447 (Linking) VI - 15 IP - 4 DP - 2010 Jul 1 TI - Efficacy and safety comparison of two amoxicillin administration schedules after third molar removal. A randomized, double-blind and controlled clinical trial. PG - e633-8 AB - OBJECTIVE: The aim of this comparative double-blind, prospective, randomized, clinical trial was to evaluate two amoxicillin administration patterns. The first was a short prophylactic therapy and the second a long postoperative regimen. STUDY DESIGN: The study population consisted of 160 patients who underwent mandibular third molar extraction. Patients were randomized into two equal groups. In group 1, 2 grams of amoxicillin were administered 1 hour before the procedure and 1 gram 6 hours after surgery. In group 2, patients received 1 gram of amoxicillin 6 hours after surgery followed by 1 gram every 8 hour for 4 days. All patients received the same number of tablets thanks to the use of placebo pills. A total of 25 variables were evaluated, such as alveolitis, surgical infection, number of analgesic needed, subjective pain scale, post-surgical inflammation, consistency of the diet, axillary temperature and millimeters of mouth opening loss after the surgery. RESULTS: No statistically significant post-operative differences were found within the recorded parameters between the groups. CONCLUSIONS: Postoperative 4-days amoxicillin therapy is not justified. FAU - Luaces-Rey, Ramón AU - Luaces-Rey R AD - Servicio de Cirugía Maxilofacial, Complejo Hospitalari A Coruña, As Xubias, 15006 A Coruña, Spain. ramon.luaces.rey@sergas.es FAU - Arenaz-Búa, Jorge AU - Arenaz-Búa J FAU - Lopez-Cedrun-Cembranos, José-Luis AU - Lopez-Cedrun-Cembranos JL FAU - Martínez-Roca, Cristina AU - Martínez-Roca C FAU - Pértega-Díaz, Sonia AU - Pértega-Díaz S FAU - Sironvalle-Soliva, Sheyla AU - Sironvalle-Soliva S LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20100701 PL - Spain TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 RN - 0 (Anti-Bacterial Agents) RN - 804826J2HU (Amoxicillin) SB - D SB - IM MH - Adult MH - Amoxicillin/*administration & dosage MH - Anti-Bacterial Agents/*administration & dosage MH - Antibiotic Prophylaxis MH - Double-Blind Method MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Molar/*surgery MH - Postoperative Care MH - Prospective Studies MH - *Tooth Extraction EDAT- 2010/02/23 06:00 MHDA- 2010/12/14 06:00 CRDT- 2010/02/23 06:00 PHST- 2009/09/01 00:00 [received] PHST- 2009/12/01 00:00 [accepted] PHST- 2010/02/23 06:00 [entrez] PHST- 2010/02/23 06:00 [pubmed] PHST- 2010/12/14 06:00 [medline] AID - 3148 [pii] AID - 10.4317/medoral.15.e633 [doi] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2010 Jul 1;15(4):e633-8. doi: 10.4317/medoral.15.e633. PMID- 33994294 OWN - NLM STAT- Publisher LR - 20210517 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) DP - 2021 Jan 11 TI - Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial. LID - S1010-5182(21)00005-6 [pii] LID - 10.1016/j.jcms.2021.01.002 [doi] AB - This randomized controlled clinical trial aimed to evaluate the preemptive effects of acetaminophen, ibuprofen, ketoprofen, nimesulide or dexamethasone on postoperative pain and edema in the surgical removal of impacted third molars. Participants underwent bilateral surgeries at 2 different times and were randomly given the test drug or placebo (split-mouth). Postoperative pain, edema and rescue medication were evaluated at different times. Study power was >80% for the observed effect size in the crossover repeated measures design. Differences between test drug and placebo were the response variable. Generalized Estimation Equation models were adjusted for each outcome. Sample comprised 5 groups (n = 20 each). Ibuprofen and nimesulide showed higher overall effects on pain scores over time, with no differences between them (p = 0.557). Acetaminophen showed significantly lower overall effects in edema control over time, when compared to other test drugs, that showed similar effects. Lower quantity of rescue medication were also observed for ibuprofen and nimesulide, with no differences between them (p = 0.999). Ibuprofen and nimesulide showed beneficial overall preemptive effects. Hence, in the decision-making process for preemptive analgesia in impacted third molar surgeries, ibuprofen and nimesulide should be considered on a case-by-case basis as the drugs of choice. CI - Copyright © 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Santos, Bianca Fernanda Espósito AU - Santos BFE AD - School of Dentistry, Department of Dental Clinics, Oral Pathology and Oral Surgery, Periodontology Division, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. FAU - Costa, Fernando Oliveira AU - Costa FO AD - School of Dentistry, Department of Dental Clinics, Oral Pathology and Oral Surgery, Periodontology Division, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. FAU - Pinto Júnior, Aécio Abner Campos AU - Pinto Júnior AAC AD - Centro Universitário de Belo Horizonte, Department of Dentistry, Belo Horizonte, Minas Gerais, Brazil. FAU - Araújo, André Vitor Alves AU - Araújo AVA AD - Private Dental Clinic, Belo Horizonte, Minas Gerais, Brazil. FAU - Cyrino, Renata Magalhães AU - Cyrino RM AD - School of Dentistry, Department of Dental Clinics, Oral Pathology and Oral Surgery, Periodontology Division, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. FAU - Cota, Luís Otávio Miranda AU - Cota LOM AD - School of Dentistry, Department of Dental Clinics, Oral Pathology and Oral Surgery, Periodontology Division, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: luiscota@ufmg.br. LA - eng PT - Journal Article DEP - 20210111 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 SB - D SB - IM OTO - NOTNLM OT - Analgesia OT - Dexamethasone OT - Ibuprofen OT - Molar OT - Nimesulide OT - Oral OT - Surgery OT - Third EDAT- 2021/05/18 06:00 MHDA- 2021/05/18 06:00 CRDT- 2021/05/17 05:49 PHST- 2020/05/31 00:00 [received] PHST- 2020/10/25 00:00 [revised] PHST- 2021/01/04 00:00 [accepted] PHST- 2021/05/17 05:49 [entrez] PHST- 2021/05/18 06:00 [pubmed] PHST- 2021/05/18 06:00 [medline] AID - S1010-5182(21)00005-6 [pii] AID - 10.1016/j.jcms.2021.01.002 [doi] PST - aheadofprint SO - J Craniomaxillofac Surg. 2021 Jan 11:S1010-5182(21)00005-6. doi: 10.1016/j.jcms.2021.01.002. PMID- 33195806 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201117 IS - 2383-9309 (Print) IS - 2383-9317 (Electronic) IS - 2383-9309 (Linking) VI - 20 IP - 5 DP - 2020 Oct TI - Do corticosteroids reduce postoperative pain following third molar intervention? PG - 281-291 LID - 10.17245/jdapm.2020.20.5.281 [doi] AB - BACKGROUND: Corticosteroids have been widely used by oral surgeons for reducing swelling caused by wisdom teeth surgery. However, they have not been proven to decrease pain. This study was aimed at analyzing previous studies pertaining to corticosteroids and pain reduction following wisdom teeth surgery. METHODS: The Science Direct, PubMed, and MEDLINE databases were searched for relevant journals according to a systematic search strategy (Patient Intervention Comparison Outcome Study). Randomized controlled trials published in English from 1998 to 2017 were extracted. RESULTS: Twenty-seven articles were included, with a total of 36 comparative cases. Methylprednisolone and dexamethasone were the most commonly used corticosteroids. Intramuscular injections of corticosteroids were optimal for pain reduction, regardless of the time of administration. CONCLUSIONS: Corticosteroids can be used as an adjuvant for pain reduction following wisdom teeth surgery. Methylprednisolone and dexamethasone delivered via the intramuscular route is the best method for effective pain reduction. The ideal time for administration of corticosteroids is the preoperative period. CI - Copyright © 2020 Journal of Dental Anesthesia and Pain Medicine. FAU - Sugragan, Chollathit AU - Sugragan C AUID- ORCID: 0000-0001-8656-1682 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Sirintawat, Nattapong AU - Sirintawat N AUID- ORCID: 0000-0002-6441-5243 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Kiattavornchareon, Sirichai AU - Kiattavornchareon S AUID- ORCID: 0000-0001-6766-9188 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Khoo, Lee Kian AU - Khoo LK AUID- ORCID: 0000-0003-4135-1563 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Kc, Kumar AU - Kc K AUID- ORCID: 0000-0001-9620-7388 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Wongsirichat, Natthamet AU - Wongsirichat N AUID- ORCID: 0000-0003-3005-2680 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20201030 TA - J Dent Anesth Pain Med JT - Journal of dental anesthesia and pain medicine JID - 101690691 PMC - PMC7644360 OTO - NOTNLM OT - Corticosteroid OT - Dexamethasone OT - Mandible OT - Postoperative Pain OT - Surgical Removal OT - Third Molar COIS- CONFLICTS OF INTEREST: The authors declared a conflict of interest. EDAT- 2020/11/17 06:00 MHDA- 2020/11/17 06:01 CRDT- 2020/11/16 08:56 PHST- 2020/05/05 00:00 [received] PHST- 2020/07/05 00:00 [revised] PHST- 2020/08/10 00:00 [accepted] PHST- 2020/11/16 08:56 [entrez] PHST- 2020/11/17 06:00 [pubmed] PHST- 2020/11/17 06:01 [medline] AID - 10.17245/jdapm.2020.20.5.281 [doi] PST - ppublish SO - J Dent Anesth Pain Med. 2020 Oct;20(5):281-291. doi: 10.17245/jdapm.2020.20.5.281. Epub 2020 Oct 30. PMID- 33748282 OWN - NLM STAT- In-Process LR - 20210323 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2021 DP - 2021 TI - Preemptive Oral Etoricoxib on Health-Related Quality of Life after Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. PG - 8888151 LID - 10.1155/2021/8888151 [doi] LID - 8888151 AB - This study was aimed at evaluating the use of oral etoricoxib for preemptive analgesia on the health-related quality of life (QoL) outcome after the extraction of mandibular third molar. The study population consisted of 60 participants that required extraction of a single partial bony impacted mandibular third molar under local anesthesia and met the inclusion criteria. The participants were randomized into two groups. The etoricoxib group orally received 60 mg etoricoxib 30 min before surgery, whereas the control group was given a placebo. The patients were assessed postoperatively after 1, 2, 3, 4, 5, 6, and 7 days using the United Kingdom oral health-related QoL questionnaire and visual analog scale for maximum postoperative pain. The total dose of ibuprofen rescue intake and total number of days the drug was taken were recorded. Surgical removal of impacted teeth had a negative influence on the patient's QoL across various physical, social, and psychological aspects. The scores for postoperative pain in the etoricoxib group were significantly lower than those in the control group on each postoperative observation day. The number of patients without analgesic rescue medication, the average amount, and total number of days emergency analgesics were taken were significantly lower in the etoricoxib group than in the control group. The etoricoxib group showed better QoL score than the control group. Preemptive oral etoricoxib is an effective therapeutic strategy for improving the QoL after surgical removal of the impacted lower third molar. CI - Copyright © 2021 Long Xie et al. FAU - Xie, Long AU - Xie L AUID- ORCID: 0000-0003-4628-2798 AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Li, Zhi AU - Li Z AUID- ORCID: 0000-0003-1927-9294 AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. FAU - Shang, Zheng-Jun AU - Shang ZJ AUID- ORCID: 0000-0002-4884-8129 AD - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. LA - eng PT - Journal Article DEP - 20210306 TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM PMC - PMC7959973 COIS- The authors declare that they have no conflicts of interest. EDAT- 2021/03/23 06:00 MHDA- 2021/03/23 06:00 CRDT- 2021/03/22 08:23 PHST- 2020/08/25 00:00 [received] PHST- 2021/01/30 00:00 [revised] PHST- 2021/02/24 00:00 [accepted] PHST- 2021/03/22 08:23 [entrez] PHST- 2021/03/23 06:00 [pubmed] PHST- 2021/03/23 06:00 [medline] AID - 10.1155/2021/8888151 [doi] PST - epublish SO - Biomed Res Int. 2021 Mar 6;2021:8888151. doi: 10.1155/2021/8888151. eCollection 2021. PMID- 15789042 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20050420 LR - 20050324 IS - 1462-0049 (Print) IS - 1462-0049 (Linking) VI - 6 IP - 1 DP - 2005 TI - No benefit from prophylactic antibiotics in third molar surgery. PG - 10 AB - DESIGN: This was a randomised controlled trial in a hospital environment. INTERVENTION: After surgical removal of third molars postoperative treatment was with oral amoxicillin-clavulanic acid (AC) or clindamycin (CL) or no antibiotics (C). The surgical technique was the same in all cases, and the follow-up period was 4 weeks. OUTCOME MEASURE: Parameters evaluated were pain, differences in mouth opening, infection, the occurrence of dry socket, and adverse postoperative side effects. RESULTS: A total of 528 lower third molars were surgically removed in 288 patients during a period of 30 months. The patients' mean age was 20.7 years (age range, 14-61 years). No severe complications such as perimandibular abscess or cellulitis occurred in any patient in any group. There was no significant difference between the groups in the overall occurrence of local infection symptoms after surgery (range, 3.4-4.4%; mean, 3.98%), nor for other parameters. Interestingly, 69.6% of the patients with dry sockets had partially erupted third molars. This rate was the same in each group (62.5% versus 75%) and did not vary significantly. Reported adverse effects were similar in each group (15.3% for AC, 12.2% for CL, 13.9% for C). CONCLUSIONS: The results show that specific postoperative oral prophylactic antibiotic treatment after the removal of lower third molars does not contribute to better wound healing, less pain nor increased mouth opening, and could not prevent the cases of inflammatory problems after surgery, respectively. It is therefore not recommended for routine use. FAU - Hill, Mike AU - Hill M AD - Department of Oral Surgery, Medicine and Pathology, Dental School, Wales College of Medicine Cardiff, UK. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 CON - J Oral Maxillofac Surg. 2004 Jan;62(1):3-8; discussion 9. PMID: 14699540 EDAT- 2005/03/25 09:00 MHDA- 2005/03/25 09:01 CRDT- 2005/03/25 09:00 PHST- 2005/03/25 09:00 [pubmed] PHST- 2005/03/25 09:01 [medline] PHST- 2005/03/25 09:00 [entrez] AID - 6400307 [pii] AID - 10.1038/sj.ebd.6400307 [doi] PST - ppublish SO - Evid Based Dent. 2005;6(1):10. doi: 10.1038/sj.ebd.6400307. PMID- 3595697 OWN - NLM STAT- MEDLINE DCOM- 19870729 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 32 IP - 3 DP - 1987 TI - Effective postoperative pain control by preoperative injection of diclofenac. PG - 249-52 AB - We have treated ninety-five patients undergoing surgical removal of third molar with diclofenac or placebo, administered double-blind either pre- or postoperatively. Postoperative pain was recorded hourly for the first 8 h using a 100 mm visual analogue scale. Preoperative administration of diclofenac produced more effective pain relief than either postoperative administration or placebo. Since diclofenac has an inhibitory action on prostaglandin synthesis prophylactic intramuscular administration may have reduced the inflammatory process before synthesis of prostaglandins was activated. FAU - Wuolijoki, E AU - Wuolijoki E FAU - Oikarinen, V J AU - Oikarinen VJ FAU - Ylipaavalniemi, P AU - Ylipaavalniemi P FAU - Hampf, G AU - Hampf G FAU - Tolvanen, M AU - Tolvanen M LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 144O8QL0L1 (Diclofenac) SB - IM MH - Adult MH - Diclofenac/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain Measurement MH - Pain, Postoperative/*prevention & control MH - *Premedication MH - Tooth Extraction EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] AID - 10.1007/BF00607571 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1987;32(3):249-52. doi: 10.1007/BF00607571. PMID- 11255522 OWN - NLM STAT- MEDLINE DCOM- 20010329 LR - 20190619 IS - 0003-4819 (Print) IS - 0003-4819 (Linking) VI - 134 IP - 6 DP - 2001 Mar 20 TI - Warfarin therapy for an octogenarian who has atrial fibrillation. PG - 465-74 AB - In North America, atrial fibrillation is associated with at least 75 000 ischemic strokes each year. Most of these strokes occur in patients older than 75 years of age. The high incidence of stroke in very elderly persons reflects the increasing prevalence of atrial fibrillation that occurs with advanced age, the high incidence of stroke in elderly patients, and the failure of physicians to prescribe antithrombotic therapy in most of these patients. This failure is related to the increased risk for major hemorrhage with advanced age, obfuscating the decision to institute stroke prophylaxis with antithrombotic therapy. This case-based review describes the risk and benefits of prescribing antithrombotic therapy for a hypothetical 80-year-old man who has atrial fibrillation and hypertension, and it offers practical advice on managing warfarin therapy. After concluding that the benefits of warfarin outweigh its risks in this patient, we describe how to initiate warfarin therapy cautiously and how to monitor and dose the drug. We then review five recent randomized, controlled trials that document the increased risk for stroke when an international normalized ratio (INR) of less than 2.0 is targeted among patients with atrial fibrillation. Next, we make the case that cardioversion is not needed for this asymptomatic patient with chronic atrial fibrillation. Instead, we choose to leave the patient in atrial fibrillation and to control his ventricular rate with atenolol. Later, when the INR increases to 4.9, we advocate withholding one dose of warfarin and repeating the INR test. Finally, when the patient develops dental pain, we review the analgesic agents that are safe to take with warfarin and explain why warfarin therapy does not have to be interrupted during a subsequent dental extraction. FAU - Gage, B F AU - Gage BF AD - Division of General Medical Science, Washington University School of Medicine, Campus Box 8005, 660 South Euclid Avenue, St. Louis, MO 63110, USA. bgage@im.wustl.edu FAU - Fihn, S D AU - Fihn SD FAU - White, R H AU - White RH LA - eng GR - R01 HS10133/HS/AHRQ HHS/United States PT - Case Reports PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - United States TA - Ann Intern Med JT - Annals of internal medicine JID - 0372351 RN - 0 (Analgesics) RN - 0 (Anticoagulants) RN - 0 (Antihypertensive Agents) RN - 50VV3VW0TI (Atenolol) RN - 5Q7ZVV76EI (Warfarin) SB - AIM SB - IM MH - Aged MH - Aged, 80 and over MH - Analgesics/administration & dosage MH - Anticoagulants/administration & dosage/*therapeutic use MH - Antihypertensive Agents/therapeutic use MH - Atenolol/therapeutic use MH - Atrial Fibrillation/complications/*drug therapy MH - Dental Care MH - Drug Administration Schedule MH - Drug Monitoring MH - Humans MH - Hypertension/complications MH - International Normalized Ratio MH - Risk Factors MH - Stroke/etiology/*prevention & control MH - Surgical Procedures, Operative MH - Warfarin/*therapeutic use RF - 116 EDAT- 2001/03/20 10:00 MHDA- 2001/04/03 10:01 CRDT- 2001/03/20 10:00 PHST- 2001/03/20 10:00 [pubmed] PHST- 2001/04/03 10:01 [medline] PHST- 2001/03/20 10:00 [entrez] AID - 200103200-00011 [pii] AID - 10.7326/0003-4819-134-6-200103200-00011 [doi] PST - ppublish SO - Ann Intern Med. 2001 Mar 20;134(6):465-74. doi: 10.7326/0003-4819-134-6-200103200-00011. PMID- 29779220 OWN - NLM STAT- MEDLINE DCOM- 20191029 LR - 20191029 IS - 1600-051X (Electronic) IS - 0303-6979 (Linking) VI - 45 IP - 7 DP - 2018 Jul TI - Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. PG - 841-850 LID - 10.1111/jcpe.12931 [doi] AB - AIM: The goal of this study was to evaluate if dental pulp stem cells (DPSCs) delivered into intrabony defects in a collagen scaffold would enhance the clinical and radiographic parameters of periodontal regeneration. MATERIALS AND METHODS: In this randomized controlled trial, 29 chronic periodontitis patients presenting one deep intrabony defect and requiring extraction of one vital tooth were consecutively enrolled. Defects were randomly assigned to test or control treatments which both consisted of the use of minimally invasive surgical technique. The dental pulp of the extracted tooth was mechanically dissociated to obtain micrografts rich in autologous DPSCs. Test sites (n = 15) were filled with micrografts seeded onto collagen sponge, whereas control sites (n = 14) with collagen sponge alone. Clinical and radiographic parameters were recorded at baseline, 6 and 12 months postoperatively. RESULTS: Test sites exhibited significantly more probing depth (PD) reduction (4.9 mm versus 3.4 mm), clinical attachment level (CAL) gain (4.5 versus 2.9 mm) and bone defect fill (3.9 versus 1.6 mm) than controls. Moreover, residual PD < 5 mm (93% versus 50%) and CAL gain ≥4 mm (73% versus 29%) were significantly more frequent in the test group. CONCLUSIONS: Application of DPSCs significantly improved clinical parameters of periodontal regeneration 1 year after treatment. CI - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Ferrarotti, Francesco AU - Ferrarotti F AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. FAU - Romano, Federica AU - Romano F AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. FAU - Gamba, Mara Noemi AU - Gamba MN AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. FAU - Quirico, Andrea AU - Quirico A AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. FAU - Giraudi, Marta AU - Giraudi M AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. FAU - Audagna, Martina AU - Audagna M AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. FAU - Aimetti, Mario AU - Aimetti M AUID- ORCID: 0000-0003-0657-0787 AD - Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180615 PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 SB - D SB - IM MH - *Alveolar Bone Loss MH - Dental Pulp MH - Follow-Up Studies MH - *Guided Tissue Regeneration, Periodontal MH - Humans MH - Periodontal Attachment Loss MH - Periodontal Pocket MH - Regeneration MH - Stem Cells MH - Treatment Outcome OTO - NOTNLM OT - *dental pulp OT - *periodontal pocket OT - *periodontal regeneration OT - *randomized controlled trial OT - *stem cells OT - *tissue engineering EDAT- 2018/05/21 06:00 MHDA- 2019/10/30 06:00 CRDT- 2018/05/21 06:00 PHST- 2017/10/24 00:00 [received] PHST- 2018/04/18 00:00 [revised] PHST- 2018/05/13 00:00 [accepted] PHST- 2018/05/21 06:00 [pubmed] PHST- 2019/10/30 06:00 [medline] PHST- 2018/05/21 06:00 [entrez] AID - 10.1111/jcpe.12931 [doi] PST - ppublish SO - J Clin Periodontol. 2018 Jul;45(7):841-850. doi: 10.1111/jcpe.12931. Epub 2018 Jun 15. PMID- 20183736 OWN - NLM STAT- MEDLINE DCOM- 20100608 LR - 20100225 IS - 1744-5183 (Electronic) IS - 0020-7144 (Linking) VI - 58 IP - 1 DP - 2010 Jan TI - Effects of hypnosis as an adjunct to intravenous sedation for third molar extraction: a randomized, blind, controlled study. PG - 21-38 LID - 10.1080/00207140903310782 [doi] AB - The effects of hypnosis/therapeutic suggestion in connection with intravenous sedation and surgery have been described in many clinical publications; however, few randomized, controlled, and blind studies have been performed in the outpatient area. This study aimed to evaluate the use of hypnosis/therapeutic suggestion as an adjunct to intravenous (IV) sedation in patients having 3rd molar removal in an outpatient setting. The patients were randomly assigned to a treatment (n = 46) or control (n = 54) group. The treatment group listened to a rapid conversational induction and therapeutic suggestions via headphones throughout the entire surgical procedure along with a standard sedation dose of intravenous anesthetic. The control group listened to only music without any hypnotic intervention. Intraoperative Propofol administration, patient postoperative pain ratings, and postoperative prescription pain reliever consumption were all significantly reduced in the treatment compared to the control group. Implications of these results are discussed. FAU - Mackey, Edward F AU - Mackey EF AD - Department of Nursing, West Chester, University of Pennsylvania, 855 S. New Street, West Chester, PA 19348, USA. emackey@wcupa.edu LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Int J Clin Exp Hypn JT - The International journal of clinical and experimental hypnosis JID - 0376166 RN - 0 (Hypnotics and Sedatives) SB - IM MH - Adolescent MH - Adult MH - Anxiety Disorders/*prevention & control/psychology MH - Double-Blind Method MH - Fear MH - Female MH - Humans MH - *Hypnosis MH - Hypnotics and Sedatives/administration & dosage/*therapeutic use MH - Injections, Intravenous MH - Male MH - *Molar MH - Tooth Extraction/*methods MH - Young Adult EDAT- 2010/02/26 06:00 MHDA- 2010/06/09 06:00 CRDT- 2010/02/26 06:00 PHST- 2010/02/26 06:00 [entrez] PHST- 2010/02/26 06:00 [pubmed] PHST- 2010/06/09 06:00 [medline] AID - 917413197 [pii] AID - 10.1080/00207140903310782 [doi] PST - ppublish SO - Int J Clin Exp Hypn. 2010 Jan;58(1):21-38. doi: 10.1080/00207140903310782. PMID- 33037794 OWN - NLM STAT- Publisher LR - 20201010 IS - 1698-6946 (Electronic) IS - 1698-4447 (Linking) DP - 2020 Oct 9 TI - A systematic review and meta-analysis on the effectiveness of xenograft to prevent periodontal defects after mandibular third molar extraction. LID - 24260 [pii] LID - 10.4317/medoral.24260 [doi] AB - BACKGROUND: To evaluate the use of guided bone regeneration with xenograft to prevent periodontal defect in the distal aspect of the second molar after the surgical removal of the mandibular third molar. MATERIAL AND METHODS: Three electronic databases (Pubmed, Cochrane Library and Scopus) were searched in April 2020. Randomized clinical trials in non-smokers and healthy patients, with at least six months follow-up, comparing periodontal probing depth, clinical attachment level, alveolar bone level and adverse events were selected by two independent investigators. The risk of bias assessment of the selected studies was evaluated by means of the Cochrane Collaboration's Tool. Finally, a meta-analysis of the outcomes of interest was performed. RESULTS: Despite 795 articles were found in the initial search, only three randomized controlled clinical trials were included. Pooled results favoured the use of the xenograft plus collagen membrane over the spontaneous healing in terms of periodontal probing depth gain (MD=2.36; 95% CI 0.69 to 4.03; P=0.005) and clinical attachment level gain (MD=2.52; 95% CI 0.96 to 4.09; P=0.002). No other statistically significant differences were found. CONCLUSIONS: Within the limitations of the present review, the xenograft plus collagen membrane exhibited better periodontal results than spontaneous healing without increasing postoperative complications. However, future well-designed studies with larger samples are required to confirm our results. FAU - Toledano-Serrabona, J AU - Toledano-Serrabona J FAU - Ruiz-Romero, V AU - Ruiz-Romero V FAU - Camps-Font, O AU - Camps-Font O FAU - Gay-Escoda, C AU - Gay-Escoda C FAU - Sánchez-Garcés, M-Á AU - Sánchez-Garcés MÁ AD - School of Medicine and Health Sciences Campus de Bellvitge, University of Barcelona Pavelló Govern, 2ª planta, Despatx 2.9, C/ Feixa Llarga, s/n 08907, L'Hospitalet de Llobregat, Barcelona, Spain ocamps@ub.edu. LA - eng PT - Journal Article DEP - 20201009 PL - Spain TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 SB - D SB - IM EDAT- 2020/10/11 06:00 MHDA- 2020/10/11 06:00 CRDT- 2020/10/10 08:32 PHST- 2020/08/20 00:00 [received] PHST- 2020/09/17 00:00 [accepted] PHST- 2020/10/10 08:32 [entrez] PHST- 2020/10/11 06:00 [pubmed] PHST- 2020/10/11 06:00 [medline] AID - 24260 [pii] AID - 10.4317/medoral.24260 [doi] PST - aheadofprint SO - Med Oral Patol Oral Cir Bucal. 2020 Oct 9:24260. doi: 10.4317/medoral.24260. PMID- 32855372 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2234-7550 (Print) IS - 2234-5930 (Electronic) IS - 1225-1585 (Linking) VI - 46 IP - 4 DP - 2020 Aug 31 TI - Buccal infiltration injection without a 4% articaine palatal injection for maxillary impacted third molar surgery. PG - 250-257 LID - 10.5125/jkaoms.2020.46.4.250 [doi] AB - OBJECTIVES: Palatal infiltration is the most painful and uncomfortable anesthesia technique for maxillary impacted third molar surgery (MITMS). This approach could cause patients distress and aversion to dental treatment. The aim of this study was to evaluate the anesthetic efficacy of a buccal infiltration injection without a palatal injection in MITMS. MATERIALS AND METHODS: This prospective research study was a crossover split mouth-randomized controlled trial. Twenty-eight healthy symmetrical bilateral MITMS patients (mean age, 23 years) were randomly assigned to two groups. Buccal infiltration injections without palatal injections were designated as the study group and the buccal with palatal infiltration cases were the control group, using 4% articaine and 1:100,000 epinephrine. The operation started after 10 minutes of infiltration. Pain assessment was done using a visual analogue scale and a numeric rating scale after each injection and extraction procedure. Similarly, the success rate, hemodynamic parameters, and additional requested local anesthetic were assessed. RESULTS: The results showed that the pain associated with local anesthetic injections between both groups were significantly different. However, the success rates between the groups were not significantly different. Postoperative pain was not significant between both groups and a few patients requested an additional local anesthetic, but the results were not statistically significant. For hemodynamic parameters, there was a significant difference in systolic pressure during incision, bone removal, and tooth elevation. In comparison, during the incision stage there was a significant difference in diastolic pressure; however, other steps in the intervention were not significantly different between groups. CONCLUSION: We concluded that buccal infiltration injection without palatal injection can be an alternative technique instead of the conventional injection for MITMS. FAU - Sochenda, Som AU - Sochenda S AUID- ORCID: 0000-0002-0397-7728 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Vorakulpipat, Chakorn AU - Vorakulpipat C AUID- ORCID: 0000-0001-6627-8732 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - C, Kumar K AU - C KK AUID- ORCID: 0000-0001-9620-7388 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Saengsirinavin, Chavengkiat AU - Saengsirinavin C AUID- ORCID: 0000-0003-1344-5036 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Rojvanakarn, Manus AU - Rojvanakarn M AUID- ORCID: 0000-0002-9986-8998 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Wongsirichat, Natthamet AU - Wongsirichat N AUID- ORCID: 0000-0003-3005-2680 AD - Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. AD - Consultant of International College of Dentistry Committee, Walailuk University International College of Dentistry, Bangkok, Thailand. LA - eng PT - Journal Article TA - J Korean Assoc Oral Maxillofac Surg JT - Journal of the Korean Association of Oral and Maxillofacial Surgeons JID - 101580242 PMC - PMC7469967 OTO - NOTNLM OT - Anesthesia OT - Articaine OT - Infiltration OT - Maxilla OT - Third molar surgery COIS- Conflict of Interest No potential conflict of interest relevant to this article was reported. EDAT- 2020/08/29 06:00 MHDA- 2020/08/29 06:01 CRDT- 2020/08/29 06:00 PHST- 2019/04/23 00:00 [received] PHST- 2019/05/29 00:00 [revised] PHST- 2019/06/03 00:00 [accepted] PHST- 2020/08/29 06:00 [entrez] PHST- 2020/08/29 06:00 [pubmed] PHST- 2020/08/29 06:01 [medline] AID - jkaoms.2020.46.4.250 [pii] AID - JKAOMS-46-250 [pii] AID - 10.5125/jkaoms.2020.46.4.250 [doi] PST - ppublish SO - J Korean Assoc Oral Maxillofac Surg. 2020 Aug 31;46(4):250-257. doi: 10.5125/jkaoms.2020.46.4.250. PMID- 6931717 OWN - NLM STAT- MEDLINE DCOM- 19801125 LR - 20100412 IS - 0012-1029 (Print) IS - 0012-1029 (Linking) VI - 35 IP - 1 DP - 1980 Jan TI - [Comparative studies on the vestibular and lingual osteotomy in the removal of lower wisdom teeth]. PG - 124-7 AB - Retained third molars and/or buds in the left and right mandible were removed unilaterally via a vestibular and lingual osteotomy in 50 patients at the department for oral surgery. Postoperative edema in addition to the operative course was registered with a measurement technique developed by the authors: wound healing and general subjective complaints were also compared. FAU - Strukmeier, A AU - Strukmeier A FAU - Pape, H D AU - Pape HD LA - ger PT - Clinical Trial PT - Controlled Clinical Trial PT - English Abstract PT - Journal Article TT - Vergleichende Untersuchungen zur vestibulären und lingualen Osteotomie bei der Entfernung unterer Weisheitszähne. PL - Germany TA - Dtsch Zahnarztl Z JT - Deutsche zahnarztliche Zeitschrift JID - 2984745R SB - D SB - IM MH - Edema/diagnosis MH - Humans MH - Mandible/*surgery MH - Molar MH - Osteotomy/*methods MH - Tooth Extraction/*methods MH - Tooth Germ/surgery MH - Tooth, Impacted/surgery MH - Wound Healing EDAT- 1980/01/01 00:00 MHDA- 1980/01/01 00:01 CRDT- 1980/01/01 00:00 PHST- 1980/01/01 00:00 [pubmed] PHST- 1980/01/01 00:01 [medline] PHST- 1980/01/01 00:00 [entrez] PST - ppublish SO - Dtsch Zahnarztl Z. 1980 Jan;35(1):124-7. PMID- 27833344 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 0972-8279 (Print) IS - 0974-942X (Electronic) IS - 0972-8270 (Linking) VI - 15 IP - 4 DP - 2016 Dec TI - Clinical Trial Evaluating the Risk of Thromboembolic Events During Dental Extractions. PG - 506-511 AB - PURPOSE: Discontinuation of anti-platelet therapy increases the risk of thrombotic complications whereas its continuation is believed to increase the risk of prolonged post-extraction bleeding. We therefore, performed this study to evaluate the risk of significant bleeding following dental extractions and also to assess the necessity of discontinuing anti-platelet therapy. PATIENTS AND METHODS: Three hundred patients requiring dental extraction were included in the study in which 200 patients were on anti-platelet therapy. Patients were divided into three groups of 100 patients each. Group 1 consisted of patients continuing their anti-platelet therapy, Group 2 consisted of patients whose anti-platelet therapy was interrupted and Group 3 comprised of healthy patients not on anti-platelet therapy. Preoperative bleeding and clotting time were determined for all patients. The procedure involved single or multiple teeth (>3 teeth) extractions under local anesthesia with a vasoconstrictor. Pressure pack was given in all cases as in routine dental extractions and bleeding was checked after 15, 30 min, 1, 24, 48 h and 1 week. Immediate post-extraction bleeding was considered to be prolonged if it continued beyond 30 min in spite of the pressure pack. Late and very late bleeding was considered to be clinically significant if it extended beyond 12 and 24 h respectively. RESULTS: The mean bleeding time in Groups 1, 2, and 3 were 1 min and 32 s, 1 min and 25 s, and 1 min and 27 s, respectively. Prolonged immediate post-extraction bleeding (bleeding after 30 min) was present among 9 patients in Group 1 (9 %) and 15 patients in Group 2 (15 %) whereas it was not seen in any patient of Group 3. Bleeding after 1 h was present in 9 patients of Group 2 (9 %) and was controlled with gelatin sponge within half an hour thereafter. None of the patients in any group reported with bleeding after 24, 48 h and 1 week. CONCLUSION: Dental extractions can be safely carried out in patients on anti-platelet therapy without the risk of significant post-extraction bleeding thus averting the risk of thromboembolic events that might take place on temporary discontinuation of antiplatelet therapy. FAU - Sadhasivam, Gokkulakrishnan AU - Sadhasivam G AD - Department of OMFS, GITAM Dental College & Hospital, Visakhapatnam, India. FAU - Bhushan, Satya AU - Bhushan S AD - Department of OMFS, GITAM Dental College & Hospital, Visakhapatnam, India. FAU - Chiang, Kho Chai AU - Chiang KC AD - Department of OMFS, GITAM Dental College & Hospital, Visakhapatnam, India. FAU - Agarwal, Neha AU - Agarwal N AD - Private Practice, Visakhapatnam, India. FAU - Vasundhar, P L AU - Vasundhar PL AD - Private Practice, Vijayawada, India. LA - eng PT - Journal Article DEP - 20160420 TA - J Maxillofac Oral Surg JT - Journal of maxillofacial and oral surgery JID - 101538309 PMC - PMC5083703 OTO - NOTNLM OT - Anti-platelet therapy OT - Aspirin and clopidogrel OT - Dental extraction OT - Thromboembolic events COIS- No conflicts of interest to declare. EDAT- 2016/11/12 06:00 MHDA- 2016/11/12 06:01 CRDT- 2016/11/12 06:00 PHST- 2015/05/29 00:00 [received] PHST- 2016/03/24 00:00 [accepted] PHST- 2016/11/12 06:00 [entrez] PHST- 2016/11/12 06:00 [pubmed] PHST- 2016/11/12 06:01 [medline] AID - 904 [pii] AID - 10.1007/s12663-016-0904-8 [doi] PST - ppublish SO - J Maxillofac Oral Surg. 2016 Dec;15(4):506-511. doi: 10.1007/s12663-016-0904-8. Epub 2016 Apr 20. PMID- 27597866 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160906 LR - 20200929 IS - 1687-8728 (Print) IS - 1687-8736 (Electronic) IS - 1687-8728 (Linking) VI - 2016 DP - 2016 TI - Comparison of Piezosurgery and Conventional Rotary Instruments for Removal of Impacted Mandibular Third Molars: A Randomized Controlled Clinical and Radiographic Trial. PG - 8169356 LID - 10.1155/2016/8169356 [doi] LID - 8169356 AB - The purpose of this study was to test the effect of the surgical removal of impacted mandibular third molars using piezosurgery versus the conventional surgical technique on postoperative sequelae and bone healing. Material and Methods. This study was carried out as a randomized controlled clinical trial: split mouth design. Twenty patients with bilateral mandibular third molar mesioangular impaction class II position B indicated for surgical extraction were treated randomly using either the piezosurgery or the conventional bur technique on each site. Duration of the procedure, postoperative edema, trismus, pain, healing, and bone density and quantity were evaluated up to 6 months postoperatively. Results. Test and control sites were compared using paired t-test. There was statistical significance in reduction of pain and swelling in test sites, where the time of the procedure was statistically increased in test site. For bone quantity and quality, statistical difference was found where test site showed better results. Conclusion. Piezosurgery technique improves quality of patient's life in form of decrease of postoperative pain, trismus, and swelling. Furthermore, it enhances bone quality within the extraction socket and bone quantity along the distal aspect of the mandibular second molar. FAU - Arakji, Hani AU - Arakji H AUID- ORCID: 0000-0002-7588-8468 AD - Oral Surgical Sciences Department, Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, Beirut Arab University, Riad El Solh, P.O. Box 11-5020, Beirut 11072809, Lebanon. FAU - Shokry, Mohamed AU - Shokry M AD - Oral Surgical Sciences Department, Faculty of Dentistry, Beirut Arab University, Riad El Solh, P.O. Box 11-5020, Beirut 11072809, Lebanon; Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. FAU - Aboelsaad, Nayer AU - Aboelsaad N AD - Oral Surgical Sciences Department, Faculty of Dentistry, Beirut Arab University, Riad El Solh, P.O. Box 11-5020, Beirut 11072809, Lebanon; Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt. LA - eng PT - Journal Article DEP - 20160814 TA - Int J Dent JT - International journal of dentistry JID - 101524183 PMC - PMC5002292 EDAT- 2016/09/07 06:00 MHDA- 2016/09/07 06:01 CRDT- 2016/09/07 06:00 PHST- 2016/03/08 00:00 [received] PHST- 2016/06/23 00:00 [revised] PHST- 2016/07/11 00:00 [accepted] PHST- 2016/09/07 06:00 [entrez] PHST- 2016/09/07 06:00 [pubmed] PHST- 2016/09/07 06:01 [medline] AID - 10.1155/2016/8169356 [doi] PST - ppublish SO - Int J Dent. 2016;2016:8169356. doi: 10.1155/2016/8169356. Epub 2016 Aug 14. PMID- 33939696 OWN - NLM STAT- In-Data-Review LR - 20210518 IS - 1549-1676 (Electronic) IS - 1549-1277 (Linking) VI - 18 IP - 5 DP - 2021 May TI - Tranexamic acid and bleeding in patients treated with non-vitamin K oral anticoagulants undergoing dental extraction: The EXTRACT-NOAC randomized clinical trial. PG - e1003601 LID - 10.1371/journal.pmed.1003601 [doi] AB - BACKGROUND: Oral bleeding after dental extraction in patients on non-vitamin K oral anticoagulants (NOACs) is a frequent problem. We investigated whether 10% tranexamic acid (TXA) mouthwash decreases post-extraction bleeding in patients treated with NOACs. METHODS AND FINDINGS: The EXTRACT-NOAC study is a randomized, double-blind, placebo-controlled, multicenter, clinical trial. Patients were randomly assigned to 10% TXA or placebo mouthwash and were instructed to use the mouthwash once prior to dental extraction, and thereafter for 3 times a day for 3 days. The primary outcome was the number of patients with any post-extraction oral bleeding up to day 7. Secondary outcomes included periprocedural, early, and delayed bleeding, and the safety outcomes included all thrombotic events. The first patient was randomized on February 9, 2018 and the last patient on March 12, 2020. Of 222 randomized patients, 218 patients were included in the full analysis set, of which 106 patients were assigned to TXA (74.8 (±8.8) years; 81 men) and 112 to placebo (72.7 (±10.7) years; 64 men). Post-extraction bleeding occurred in 28 (26.4%) patients in the TXA group and in 32 (28.6%) patients in the placebo group (relative risk, 0.92; 95% confidence interval [CI], 0.60 to 1.42; P = 0.72). There were 46 bleeds in the TXA group and 85 bleeds in the placebo group (rate ratio, 0.57; 95% CI, 0.31 to 1.05; P = 0.07). TXA did not reduce the rate of periprocedural bleeding (bleeding score 4 ± 1.78 versus 4 ± 1.82, P = 0.80) and early bleeding (rate ratio, 0.76; 95% CI, 0.42 to 1.37). Delayed bleeding (rate ratio, 0.32; 95% CI, 0.12 to 0.89) and bleeding after multiple extractions (rate ratio, 0.40; 95% CI, 0.20 to 0.78) were lower in the TXA group. One patient in the placebo group had a transient ischemic attack while interrupting the NOAC therapy in preparation for the dental extraction. Two of the study limitations were the premature interruption of the trial following a futility analysis and the assessment of the patients' compliance that was based on self-reported information during follow-up. CONCLUSIONS: In patients on NOACs undergoing dental extraction, TXA does not seem to reduce the rate of periprocedural or early postoperative oral bleeding compared to placebo. TXA appears to reduce delayed bleeds and postoperative oral bleeding if multiple teeth are extracted. TRIAL REGISTRATION: ClinicalTrials.gov NCT03413891 EudraCT; EudraCT number:2017-001426-17; EudraCT Public website: eudract.ema.europa.eu. FAU - Ockerman, Anna AU - Ockerman A AUID- ORCID: 0000-0002-0635-2774 AD - Oral and Maxillofacial Surgery-Imaging and Pathology Research Group, Department of Imaging and Pathology, University of Leuven and Department of Oral & Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium. FAU - Miclotte, Isabel AU - Miclotte I AD - Oral and Maxillofacial Surgery-Imaging and Pathology Research Group, Department of Imaging and Pathology, University of Leuven and Department of Oral & Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium. FAU - Vanhaverbeke, Maarten AU - Vanhaverbeke M AUID- ORCID: 0000-0002-4385-7069 AD - Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium. FAU - Vanassche, Thomas AU - Vanassche T AUID- ORCID: 0000-0002-7404-8918 AD - Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium. FAU - Belmans, Ann AU - Belmans A AUID- ORCID: 0000-0003-1332-2917 AD - Leuven Biostatistics and Statistical Bioinformatics Centre, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium. FAU - Vanhove, Jan AU - Vanhove J AD - Oral & Maxillofacial Surgery, Regional Hospital Heilig Hart Leuven, Leuven, Belgium. FAU - Meyns, Joeri AU - Meyns J AUID- ORCID: 0000-0002-8702-6144 AD - Oral & Maxillofacial Surgery, General Hospital St-Jan Genk, Genk, Belgium. FAU - Nadjmi, Nasser AU - Nadjmi N AUID- ORCID: 0000-0002-0160-7256 AD - Department of Cranio-Maxillofacial Surgery, University of Antwerp, Antwerp, Belgium. AD - Oral & Maxillofacial Surgery, ZMACK Association, AZ Monica Antwerp, Antwerp, Belgium. FAU - Van Hemelen, Geert AU - Van Hemelen G AD - Oral & Maxillofacial Surgery, ZMACK Association, AZ Monica Antwerp, Antwerp, Belgium. FAU - Winderickx, Patrick AU - Winderickx P AD - Oral & Maxillofacial Surgery, ZMACK Association, AZ Monica Antwerp, Antwerp, Belgium. FAU - Jacobs, Reinhilde AU - Jacobs R AUID- ORCID: 0000-0002-3461-0363 AD - Oral and Maxillofacial Surgery-Imaging and Pathology Research Group, Department of Imaging and Pathology, University of Leuven and Department of Oral & Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium. AD - Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Politis, Constantinus AU - Politis C AUID- ORCID: 0000-0003-4772-9897 AD - Oral and Maxillofacial Surgery-Imaging and Pathology Research Group, Department of Imaging and Pathology, University of Leuven and Department of Oral & Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium. FAU - Verhamme, Peter AU - Verhamme P AUID- ORCID: 0000-0001-8698-2858 AD - Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT03413891 PT - Journal Article DEP - 20210503 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM COIS- I have read the journal’s policy and the authors of this manuscript have the following competing interests: PV received grants and personal fees from Bayer Healthcare, Boehringer Ingelheim, Pfizer, BMS, Daiichi-Sankyo, Leo Pharma, and Portola and Medtronic outside the submitted work. Other authors have declared that no competing interests exist. EDAT- 2021/05/04 06:00 MHDA- 2021/05/04 06:00 CRDT- 2021/05/03 17:34 PHST- 2021/02/04 00:00 [received] PHST- 2021/04/01 00:00 [accepted] PHST- 2021/05/17 00:00 [revised] PHST- 2021/05/04 06:00 [pubmed] PHST- 2021/05/04 06:00 [medline] PHST- 2021/05/03 17:34 [entrez] AID - PMEDICINE-D-21-00592 [pii] AID - 10.1371/journal.pmed.1003601 [doi] PST - epublish SO - PLoS Med. 2021 May 3;18(5):e1003601. doi: 10.1371/journal.pmed.1003601. eCollection 2021 May. PMID- 25219986 OWN - NLM STAT- MEDLINE DCOM- 20150528 LR - 20191113 IS - 1812-2078 (Electronic) IS - 1812-2027 (Linking) VI - 12 IP - 45 DP - 2014 Jan-Mar TI - Effect of single dose intramuscular methylprednisolone injection into the masseter muscle on the surgical extraction of impacted lower third molars: a randomized controlled trial. PG - 4-8 AB - BACKGROUND: Lower impacted third molar surgical extraction usually causes post-surgical sequelae like pain, trismus and swelling as a result of postoperative inflammatory response. OBJECTIVE: The aim of this study was to evaluate and compare the efficacy of single dose 40-mg (1 cc) of methylprednisolone acetate, injected into the masseter muscle, preoperatively one hour before the surgery or post-operatively, immediately following the surgical removal of impacted lower third molars, in controlling most common postoperative sequelae, i.e. trismus, pain and swelling of facial soft tissue. METHODS: A randomized control study was done of 60 patients. Each patient was categorized in two groups, group I and group II, according to the time of receiving methylprednisolone acetate. Group I was injected 40 mg of methylprednisolone acetate into the masseter muscle via the intrabuccal approach, one hour before the surgery. Group II was injected 40 mg of methylprednisolone acetate into the masseter muscle via the intrabuccal approach, immediately after suturing of the surgical wound. The washout period was one month after the first operation. Evaluation were made of postoperative pain, trismus and swelling. The numeric pain scale (NPS) was used for pain assessment. RESULTS: When the patients were administered methylprednisolone acetate preoperatively, showed superior results in terms of oral aperture, pain and all the facial swelling parameters, with statistically significant differences versus the postoperatively administered methylprednisolone acetate (p < 0.05). CONCLUSIONS: A single dose of 40 mg (1 cc) methylprednisolone acetate injected into the masseter muscle preoperatively is more effective in reducing pain, trismus and swelling, when compared to that administered postoperatively. FAU - Vyas, N AU - Vyas N AD - Department of Oral and Maxillofacial Surgery, Ahmedabad Dental College and Hospital, Gujarat, India. FAU - Agarwal, S AU - Agarwal S AD - Department of Oral and Maxillofacial Surgery, Ahmedabad Dental College and Hospital, Gujarat, India. FAU - Shah, N AU - Shah N AD - Department of Oral and Maxillofacial Surgery, Ahmedabad Dental College and Hospital, Gujarat, India. FAU - Patel, D AU - Patel D AD - Department of Oral and Maxillofacial Surgery, Ahmedabad Dental College and Hospital, Gujarat, India. FAU - Aapaliya, P AU - Aapaliya P AD - Department of Public Health Dentistry, Pacific, Dental College and Hospital, Rajasthan, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Nepal TA - Kathmandu Univ Med J (KUMJ) JT - Kathmandu University medical journal (KUMJ) JID - 101215359 RN - 0 (Glucocorticoids) RN - X4W7ZR7023 (Methylprednisolone) SB - IM MH - Adolescent MH - Adult MH - Female MH - Glucocorticoids/*administration & dosage MH - Humans MH - Injections, Intramuscular MH - Male MH - Masseter Muscle MH - Methylprednisolone/*administration & dosage MH - Molar/*surgery MH - Pain Measurement MH - Pain, Postoperative/epidemiology MH - Tooth, Impacted/*surgery MH - Young Adult EDAT- 2014/09/16 06:00 MHDA- 2015/05/29 06:00 CRDT- 2014/09/16 06:00 PHST- 2014/09/16 06:00 [entrez] PHST- 2014/09/16 06:00 [pubmed] PHST- 2015/05/29 06:00 [medline] AID - 10.3126/kumj.v12i1.13625 [doi] PST - ppublish SO - Kathmandu Univ Med J (KUMJ). 2014 Jan-Mar;12(45):4-8. doi: 10.3126/kumj.v12i1.13625. PMID- 29072242 OWN - NLM STAT- MEDLINE DCOM- 20180528 LR - 20181202 IS - 1119-3077 (Print) VI - 20 IP - 9 DP - 2017 Sep TI - Comparison of the EndoVac system and conventional needle irrigation on removal of the smear layer in primary molar root canals. PG - 1168-1174 LID - 10.4103/1119-3077.181351 [doi] AB - OBJECTIVE: This study aimed to compare the EndoVac system and conventional needle irrigation in removing smear layer (SR) from primary molar root canals. MATERIALS AND METHODS: Fifty extracted human primary second molar roots were instrumented up to an apical size of 0.04/35 and randomly divided into two main groups; Group 1: EndoVac system (n = 25) and Group 2: Conventional needle irrigation (n = 25) and three subgroups (a) NaOCl + ethylenediaminetetraacetic acid (EDTA) (n = 20) (b) ozonated water (OW) + EDTA (n = 20) and (c) saline (control, n = 10). After a standardized final irrigation protocol performed for all teeth, scanning electron microscope images were taken at ×1000 magnification for each thirds of each root canal. Data were analyzed by the weighted kappa, Kruskal-Wallis, and Wilcoxon signed rank tests. RESULTS: EndoVac was more effective than conventional needle in the removal of SR from the apical third of the root canal system (P < 0.05). The OW + EDTA regimen provided similar SR removal compared with NaOCl + EDTA. CONCLUSIONS: EndoVac has better performance than conventional needle irrigation in the removal of the SR in the apical thirds of the primary molar root canals. As a final irrigation regimen, the OW + EDTA regimen is as effective as the NaOCl + EDTA regimen. FAU - Buldur, B AU - Buldur B AD - Department of Pediatric Dentistry, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey. FAU - Kapdan, A AU - Kapdan A AD - Department of Pediatric Dentistry, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 RN - 0 (Root Canal Irrigants) RN - 9G34HU7RV0 (Edetic Acid) RN - DY38VHM5OD (Sodium Hypochlorite) SB - IM MH - Debridement/*instrumentation/methods MH - Dental Pulp Cavity/*diagnostic imaging/drug effects MH - Edetic Acid/administration & dosage MH - Humans MH - *Microscopy, Electron, Scanning MH - Molar MH - *Needles MH - Root Canal Irrigants/*administration & dosage/*pharmacology/therapeutic use MH - Root Canal Preparation/*instrumentation/methods MH - Root Canal Therapy/*instrumentation MH - Smear Layer/*therapy MH - Sodium Hypochlorite/administration & dosage MH - Therapeutic Irrigation/*instrumentation/methods MH - Tooth, Deciduous MH - Vacuum EDAT- 2017/10/27 06:00 MHDA- 2018/05/29 06:00 CRDT- 2017/10/27 06:00 PHST- 2017/10/27 06:00 [entrez] PHST- 2017/10/27 06:00 [pubmed] PHST- 2018/05/29 06:00 [medline] AID - NigerJClinPract_2017_20_9_1168_181351 [pii] AID - 10.4103/1119-3077.181351 [doi] PST - ppublish SO - Niger J Clin Pract. 2017 Sep;20(9):1168-1174. doi: 10.4103/1119-3077.181351. PMID- 23270285 OWN - NLM STAT- MEDLINE DCOM- 20130212 LR - 20190521 IS - 1591-996X (Print) IS - 1591-996X (Linking) VI - 13 IP - 4 DP - 2012 Dec TI - Clinical and radiographic outcomes of direct pulp capping therapy in primary molar teeth following haemostasis with various antiseptics: a randomised controlled trial. PG - 289-92 AB - AIM: This was to evaluate the clinical and radiographic outcomes of direct pulp capping (DPC) therapy in primary molar teeth following haemostasis with various antiseptics for 12 months. MATERIALS AND METHODS: A total of 70 vital primary molar teeth with deep dentin caries were randomly allocated to different antiseptic groups. After observing the pinpoint exposure, 0.9% saline solution (SS, control), 0.5% sodium hypochlorite (SH), 2% chlorhexidine digluconate (CHX), or 0.1% octenidine dihydrochloride (OCT) was applied with sterile cotton pellets for 3 min before calcium hydroxide (CH) DPC therapy. Statistical evaluation: The intergroup radiographic success criteria were analysed using a Kruskal-Wallis test in each follow-up period at a confidence interval of 95%. RESULTS: After 12 months, all groups showed a clinical success rate of 100% (no clinical failures were observed at the time of pulpectomy or extraction), and the overall radiographic success rates were OCT (100%) > SH (94.74%) > CHX (93.3%) > SS (84.21%), respectively (p > 0.05). OCT did not exhibit any failures. The undesirable radiographic failure types (pulpectomy or extraction) were mostly observed in the SS group. CONCLUSION: Compared with SS, the success of conventional CH usage in DPC therapy of primary molar teeth could be enhanced by providing acceptable disinfection features with antiseptic solutions. OCT seems to have relative beneficial effects compared to SH and CHX. FAU - Tüzüner, T AU - Tüzüner T AD - Department of Paediatric Dentistry, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. tamertuzuner@gmail.com FAU - Alacam, A AU - Alacam A FAU - Altunbas, D A AU - Altunbas DA FAU - Gokdogan, F G AU - Gokdogan FG FAU - Gundogdu, E AU - Gundogdu E LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Italy TA - Eur J Paediatr Dent JT - European journal of paediatric dentistry JID - 101121881 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Methylmethacrylates) RN - 0 (Pulp Capping and Pulpectomy Agents) RN - 0 (Pyridines) RN - 0 (Zinc Oxide-Eugenol Cement) RN - 12597-68-1 (Stainless Steel) RN - 60318-33-4 (IRM cement) RN - 8049-85-2 (Dental Amalgam) RN - DY38VHM5OD (Sodium Hypochlorite) RN - MOR84MUD8E (chlorhexidine gluconate) RN - OZE0372S5A (octenidine) RN - PF5DZW74VN (Calcium Hydroxide) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Anti-Infective Agents, Local/*therapeutic use MH - Calcium Hydroxide/therapeutic use MH - Child MH - Chlorhexidine/analogs & derivatives/therapeutic use MH - Crowns MH - Dental Amalgam/chemistry MH - Dental Caries/therapy MH - Dental Cavity Lining MH - Dental Pulp Capping/*methods MH - Dental Restoration, Permanent/methods MH - Female MH - Follow-Up Studies MH - *Hemostatic Techniques MH - Humans MH - Male MH - Methylmethacrylates/chemistry MH - Molar/diagnostic imaging/*pathology MH - Periapical Diseases/diagnostic imaging MH - Pulp Capping and Pulpectomy Agents/therapeutic use MH - Pyridines/therapeutic use MH - Radiography MH - Root Resorption/diagnostic imaging MH - Single-Blind Method MH - Sodium Hypochlorite/therapeutic use MH - Stainless Steel/chemistry MH - Time Factors MH - Tooth, Deciduous/diagnostic imaging/*pathology MH - Treatment Outcome MH - Zinc Oxide-Eugenol Cement/chemistry EDAT- 2012/12/29 06:00 MHDA- 2013/02/13 06:00 CRDT- 2012/12/29 06:00 PHST- 2012/12/29 06:00 [entrez] PHST- 2012/12/29 06:00 [pubmed] PHST- 2013/02/13 06:00 [medline] PST - ppublish SO - Eur J Paediatr Dent. 2012 Dec;13(4):289-92. PMID- 6707231 OWN - NLM STAT- MEDLINE DCOM- 19840517 LR - 20201209 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 24 IP - 1 DP - 1984 Jan TI - Analgesic efficacy after single and repeated doses of codeine and acetaminophen. PG - 27-34 AB - A double-blind randomized analgesic trial was carried out in patients suffering from pain after removal of a third molar tooth. In a two-dose regimen, 108 patients received either 60 mg codeine, 500 mg acetaminophen, or 1000 mg acetaminophen. On the day of surgery, the patients assessed their pain intensity hourly on a visual analog scale. The evaluation was carried out during the 10-hour period after first medication. The best pain reducing effects were achieved with 1000 mg acetaminophen. Both the category and position of each tooth were examined in relation to pain intensity; however, the statistical analysis did not reveal any significant correlation. In all treatment groups, the efficacy of the second dose was superior to that of the first, and the most pronounced difference was obtained in patients taking codeine, who increased their pain reduction from 20 to 60 per cent. Clinical comparisons including codeine may therefore be better carried out in a repeated-dose regimen. FAU - Quiding, H AU - Quiding H FAU - Oikarinen, V AU - Oikarinen V FAU - Sane, J AU - Sane J FAU - Sjöblad, A M AU - Sjöblad AM LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 362O9ITL9D (Acetaminophen) RN - UX6OWY2V7J (Codeine) SB - IM MH - Acetaminophen/*administration & dosage MH - Adult MH - Analgesia MH - Codeine/*administration & dosage MH - Humans MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction EDAT- 1984/01/01 00:00 MHDA- 1984/01/01 00:01 CRDT- 1984/01/01 00:00 PHST- 1984/01/01 00:00 [pubmed] PHST- 1984/01/01 00:01 [medline] PHST- 1984/01/01 00:00 [entrez] AID - 10.1002/j.1552-4604.1984.tb01810.x [doi] PST - ppublish SO - J Clin Pharmacol. 1984 Jan;24(1):27-34. doi: 10.1002/j.1552-4604.1984.tb01810.x. PMID- 7151849 OWN - NLM STAT- MEDLINE DCOM- 19830311 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 23 IP - 5 DP - 1982 TI - The use of pain scales in assessing the efficacy of analgesics in post-operative dental pain. PG - 441-4 AB - Two 10 cm visual analogue scales were compared with a 0-10 point numerical rating scale and a four-point verbal descriptive scale, in assessing pain severity in twelve patients with post-operative pain following removal of an impacted lower third molar. High correlations were shown between the pain scores from the two visual analogue scales and the numerical scale, but a lower correlation was obtained when the four-point scale was compared with the other scales. Analgesic efficacy was found to be dependent on the type of scale used. The 10 cm visual analogue scale was more sensitive than other pain scales and could discriminate between small changes in pain intensity. FAU - Seymour, R A AU - Seymour RA LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Analgesics) RN - R16CO5Y76E (Aspirin) SB - IM MH - Adult MH - Analgesics/*therapeutic use MH - Aspirin/therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain/*physiopathology MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/adverse effects MH - Tooth, Impacted/surgery EDAT- 1982/01/01 00:00 MHDA- 1982/01/01 00:01 CRDT- 1982/01/01 00:00 PHST- 1982/01/01 00:00 [pubmed] PHST- 1982/01/01 00:01 [medline] PHST- 1982/01/01 00:00 [entrez] AID - 10.1007/BF00605995 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1982;23(5):441-4. doi: 10.1007/BF00605995. PMID- 27891453 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2249-782X (Print) IS - 0973-709X (Electronic) IS - 0973-709X (Linking) VI - 10 IP - 10 DP - 2016 Oct TI - Efficacy of Ketamine as an Adjunct to Local Anesthesia in the Surgical Removal of Impacted Mandibular Third Molars - A Split Mouth Prospective Controlled Clinical Study. PG - ZC29-ZC33 AB - INTRODUCTION: The removal of impacted teeth is one of the most common procedures performed by oral and maxillofacial surgeons. Reduction of discomfort post-operatively and efficient local anesthesia are imperative for success in surgical practice. At sub-anesthetic doses, ketamine has a noticeable analgesic action, which can be used to supplement local anesthesia with minimal side effects. AIM: To assess the efficacy of low-dose ketamine as an adjunct to local anesthesia in the management of pain, swelling and trismus after surgical removal of impacted mandibular third molars. MATERIALS AND METHODS: Twenty five patients with bilaterally symmetrical impacted mandibular third molars requiring surgical removal under local anesthesia were selected for the controlled clinical study. The third molar sites of all patients enrolled in the trial were randomly assigned into 2 groups: Local Anesthesia (Lignocaine) Alone [LAA] and Local Anesthesia plus ketamine [LAK]. 5ml of local anesthetic (Lignocaine Hydrochloride 2% with epinephrine 1:100,000) was injected in the 'LAA' group while the 'LAK' group received 5ml of local anesthetic plus 0.2mg/kg ketamine. Patients were blinded to the solution used and the operator recorded the group (LAA or LAK) and the respective site (Right or Left) for analysis. Bilaterally symmetrical impacted mandibular molars were removed at an interval of 15 days. RESULTS: Facial swelling on post-operative days was significantly lower in the LAK group than in the LAA group (p<0.05). The pain scores on the VAS were significantly higher in the LAA group than in the LAK group (p<0.05). CONCLUSION: The role of ketamine in low doses as an analgesic and anti-inflammatory is evident in our study. The combination of a local anesthetic and sub-anesthetic doses of ketamine injected for surgical removal of impacted third molars provides good local anesthesia while alleviating post-operative sequelae for the patient by providing a degree of post-operative analgesia with less swelling. FAU - Shah, Anand AU - Shah A AD - Ex-Postgraduate, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital , Pune, Maharasthra, India . FAU - Halli, Rajshekhar AU - Halli R AD - Professor, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital , Pune, Maharasthra, India . FAU - Merchant, Yash AU - Merchant Y AD - Chief Resident, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital , Pune, Maharasthra, India . FAU - Kshirsagar, Rajesh AU - Kshirsagar R AD - Professor and Head of Department, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital , Pune, Maharasthra, India . FAU - Khurana, Jyotsana AU - Khurana J AD - Ex-Postgraduate, Department of Periodontology, Bharati Vidyapeeth Deemed University Dental College and Hospital , Pune, Maharasthra, India . LA - eng PT - Journal Article DEP - 20161001 TA - J Clin Diagn Res JT - Journal of clinical and diagnostic research : JCDR JID - 101488993 PMC - PMC5121799 OTO - NOTNLM OT - Impacted teeth OT - Post-operative pain OT - Swelling OT - Trismus EDAT- 2016/11/29 06:00 MHDA- 2016/11/29 06:01 CRDT- 2016/11/29 06:00 PHST- 2016/02/21 00:00 [received] PHST- 2016/07/04 00:00 [accepted] PHST- 2016/11/29 06:00 [entrez] PHST- 2016/11/29 06:00 [pubmed] PHST- 2016/11/29 06:01 [medline] AID - 10.7860/JCDR/2016/19677.8638 [doi] PST - ppublish SO - J Clin Diagn Res. 2016 Oct;10(10):ZC29-ZC33. doi: 10.7860/JCDR/2016/19677.8638. Epub 2016 Oct 1. PMID- 25729233 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150302 LR - 20201001 IS - 0972-8279 (Print) IS - 0974-942X (Electronic) IS - 0972-8270 (Linking) VI - 14 IP - 1 DP - 2015 Mar TI - The effect of alloplastic bone graft and absorbable gelatin sponge in prevention of periodontal defects on the distal aspect of mandibular second molars, after surgical removal of impacted mandibular third molar: a comparative prospective study. PG - 101-6 LID - 10.1007/s12663-013-0599-z [doi] AB - AIM: Recent studies claim that haemostatic agents can be used as bone graft substitutes. The aim of this study was to compare the efficacy of alloplastic bone graft with absorbable gelatin sponge in prevention of periodontal defects distal to mandibular second molar after the surgical removal of impacted mandibular third molars. MATERIALS AND METHODS: A prospective, randomized, single-blind split-mouth study was designed. The study consisted of 25 patients requiring surgical removal of bilateral impacted mandibular 3rd molars. The surgical sites were randomly divided into 2 groups: group I: G-graft (hydroxyapatite + collagen, study group) and group II: Abgel (absorbable gelatin sponge, control group). Patients were recalled on lst and 7th postoperative days and 3rd and 6th postoperative months. Probing depth, alveolar bone levels and soft tissue wound healing were evaluated. Paired t test was used to compare pre and post-operative alveolar bone levels and probing depth (PD). Wilcoxon signed ranks test was used to compare the wound healing. RESULTS: The soft tissue wound healing, PD and the distance between the cemento-enamel junction on the distal aspect of mandibular second molar (point A) and the alveolar crest on the distal aspect of the same tooth (point B) were significantly higher in group I as compared to group II. CONCLUSION: This study reveals an increase in the alveolar bone level, improvement of PD and better wound healing in group I. Group II subjects required longer healing time than the normal. The authors disagree the claim that the haemostatic agents can be used as bone graft substitutes. However, long-term, multicenter, randomized controlled clinical trials are required. FAU - Singh, Manju AU - Singh M AD - Department of Oral and Maxillofacial Surgery, Dr. DY Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, 411018 India. FAU - Bhate, Kalyani AU - Bhate K AD - Department of Oral and Maxillofacial Surgery, Dr. DY Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, 411018 India. FAU - Kulkarni, Deepak AU - Kulkarni D AD - Department of Oral and Maxillofacial Surgery, Dr. DY Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, 411018 India. FAU - Santhosh Kumar, S N AU - Santhosh Kumar SN AD - Department of Oral and Maxillofacial Surgery, Dr. DY Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, 411018 India. FAU - Kathariya, Rahul AU - Kathariya R AD - Department of Periodontics, Dr. DY. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018 Maharashtra India. LA - eng PT - Journal Article DEP - 20131114 TA - J Maxillofac Oral Surg JT - Journal of maxillofacial and oral surgery JID - 101538309 PMC - PMC4339342 OTO - NOTNLM OT - Collagen OT - Hemostatics OT - Hydroxyapatite-beta tricalcium phosphate OT - Impacted teeth EDAT- 2015/03/03 06:00 MHDA- 2015/03/03 06:01 CRDT- 2015/03/03 06:00 PHST- 2013/04/06 00:00 [received] PHST- 2013/10/14 00:00 [accepted] PHST- 2015/03/03 06:00 [entrez] PHST- 2015/03/03 06:00 [pubmed] PHST- 2015/03/03 06:01 [medline] AID - 599 [pii] AID - 10.1007/s12663-013-0599-z [doi] PST - ppublish SO - J Maxillofac Oral Surg. 2015 Mar;14(1):101-6. doi: 10.1007/s12663-013-0599-z. Epub 2013 Nov 14. PMID- 11469292 OWN - NLM STAT- MEDLINE DCOM- 20010920 LR - 20131121 IS - 0099-2399 (Print) IS - 0099-2399 (Linking) VI - 26 IP - 11 DP - 2000 Nov TI - Effect of CO2, Nd:YAG, and ArF excimer lasers on dentin morphology and pulp chamber temperature: an in vitro study. PG - 644-8 AB - This study compared the effect of three laser systems: CO2 (10.600 nm), Nd:YAG (1.064 nm), and ArF excimer (193 nm) lasers on dentin hard tissue and on temperature increases of the pulp chamber. Sixty-six third molar teeth were used and randomly divided into three groups. A class I cavity was made to expose the dentin, and the pulp in the pulp chamber was removed via a hole bored in the cervical area. The pulp chamber was subsequently refilled with silicon grease, and a NiCr/NiSi thermocouple was inserted through the hole into the pulp chamber. The dentin surface was then lased for 30 s at the same settings (3 W, 2 mm spot size, 20 pps) with each laser. The average internal temperature increases were as follows: CO2, 37 degrees C; Nd: YAG, 28 degrees C; and ArF excimer, 1 degrees C. Scanning electron microscopy of the dentin in the occlusal cavity revealed extensive carbonization, isolated balls of recrystallized material, and the presence of smear layer at some dentinal tubule orifices for the CO2 and Nd:YAG lased teeth. Smear layer was also observed for the ArF excimer samples; however, they exhibited far less surface cavities than the others and seemed to undergo little morphological change on the dentin. FAU - Türkmen, C AU - Türkmen C AD - Department of Operative Dentistry, Faculty of Dentistry, Marmara University, Istanbul, Turkey. FAU - Günday, M AU - Günday M FAU - Karaçorlu, M AU - Karaçorlu M FAU - Başaran, B AU - Başaran B LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Endod JT - Journal of endodontics JID - 7511484 RN - 0 (Aluminum Silicates) RN - 0 (Chromium Alloys) RN - 142M471B3J (Carbon Dioxide) RN - 2I87U3734A (Neodymium) RN - 58784XQC3Y (Yttrium) RN - 59680-91-0 (argon fluoride) RN - 67XQY1V3KH (Argon) RN - 7440-44-0 (Carbon) RN - 7OV03QG267 (Nickel) RN - Q80VPU408O (Fluorides) RN - Z4152N8IUI (Silicon) SB - D MH - Aluminum Silicates MH - Argon MH - Body Temperature/radiation effects MH - Carbon MH - Carbon Dioxide MH - Chromium Alloys MH - Crystallization MH - Dental Cavity Preparation/classification MH - Dental Pulp Cavity/physiology/*radiation effects MH - Dentin/*radiation effects/ultrastructure MH - Fluorides MH - Humans MH - *Lasers MH - Microscopy, Electron, Scanning MH - Molar MH - Neodymium MH - Nickel MH - Silicon MH - Smear Layer MH - Statistics as Topic MH - Thermometers MH - Time Factors MH - Yttrium EDAT- 2001/07/27 10:00 MHDA- 2001/09/21 10:01 CRDT- 2001/07/27 10:00 PHST- 2001/07/27 10:00 [pubmed] PHST- 2001/09/21 10:01 [medline] PHST- 2001/07/27 10:00 [entrez] AID - S0099-2399(05)60807-2 [pii] AID - 10.1097/00004770-200011000-00003 [doi] PST - ppublish SO - J Endod. 2000 Nov;26(11):644-8. doi: 10.1097/00004770-200011000-00003. PMID- 31326593 OWN - NLM STAT- MEDLINE DCOM- 20200713 LR - 20200713 IS - 2468-7855 (Electronic) IS - 2468-7855 (Linking) VI - 121 IP - 2 DP - 2020 Apr TI - Ropivacaine versus placebo on postoperative analgesia and chronic pain following third molar extraction: A Prospective Randomized Controlled Study. PG - 113-117 LID - S2468-7855(19)30170-3 [pii] LID - 10.1016/j.jormas.2019.07.005 [doi] AB - PURPOSE: The present study aimed at assessing the efficiency of ropivacaine on post-operative pain for extraction of third molars. METHODS: In a single centre, prospective, parallel, double blind randomised trial, patients scheduled for removal of all four third molars, ASA I-III patients<65 year-old patients were included. After intubation under general anesthesia (using intravenous remifentanil and propofol), for each of the third molars, 2mL of ropivacaine (7.5mg/mL) or placebo (0.9% saline solution) was injected into the vestibular capsule (total: 8mL) before extraction. At the end of surgery, similar analgesia was injected for both groups (intravenous paracetamol 1g and ketoprofene 100mg). The primary outcome was postoperative pain assessed by Visual Analog Scale (VAS). Postoperative consumption of analgesics (morphine titration in post-operative care unit when VAS>3/10, followed by oral tramadol 50mg after discharge), patient satisfaction, chronic pain (1-3 month), time in PACU and total hospitalization time were also recorded. RESULTS: A total of 50 patients were analysed in each group with similar characteristics (ropivacaine vs. control, for age (years) 18 [17-21] vs. 18 [17-21], for sex (female) 33 (66%) vs. 25 (50%), and BMI (kg/m(2)): 20 [19-23] vs. 21 [19-23]). Area Under the Curve for VAS pain (0 to 4h) was lower for Ropivacaine group: 0.43 [0.19-0.66] vs. 0.63 [0.43-0.87], P=0.005. Use of morphine in PACU (8 vs. 18, P=0.02) and median length of stay in ambulatory setting (5 vs. 6h, P=0.03) were reduced in Ropivacaine vs. Placebo group. At days 1 and 4, VAS of pain was higher in Ropivacaine group (respectively 4 vs. 2, P=0.006 and 3 vs. 2, P=0.05). At month 1 and 3, pain and DN4 score were similar between groups, with a median VAS pain score at 0 for both groups (P=0.42). No difference was observed for patient satisfaction and adverse events. CONCLUSIONS: Ropivacaine provides an immediate efficient pain relief after extraction of third molars without benefit after discharge. CLINICALTRIAL REGISTRATION: NCT01541059. CI - Copyright © 2019. Published by Elsevier Masson SAS. FAU - Ghezal, H AU - Ghezal H AD - Department of Anaesthesia, Pain and Intensive Care Medicine, Univ. Montpellier 1, CHU de Nîmes, place du Professeur Debré, 30029 Nîmes cedex 09, France. FAU - Bouvet, S AU - Bouvet S AD - Department of Biostatistics, Epidemiology, Public Health and Innovation in Methodology (BESPIM), Univ. Montpellier, CHU de Nîmes, Nîmes, France. FAU - Kabani, S AU - Kabani S AD - Department of Biostatistics, Epidemiology, Public Health and Innovation in Methodology (BESPIM), Univ. Montpellier, CHU de Nîmes, Nîmes, France. FAU - Ripart, J AU - Ripart J AD - Department of Anaesthesia, Pain and Intensive Care Medicine, Univ. Montpellier 1, CHU de Nîmes, place du Professeur Debré, 30029 Nîmes cedex 09, France. FAU - Cuvillon, P AU - Cuvillon P AD - Department of Anaesthesia, Pain and Intensive Care Medicine, Univ. Montpellier 1, CHU de Nîmes, place du Professeur Debré, 30029 Nîmes cedex 09, France. Electronic address: philippe.cuvillon@chu-nimes.fr. LA - eng SI - ClinicalTrials.gov/NCT01541059 PT - Journal Article PT - Randomized Controlled Trial DEP - 20190718 PL - France TA - J Stomatol Oral Maxillofac Surg JT - Journal of stomatology, oral and maxillofacial surgery JID - 101701089 RN - 0 (Amides) RN - 0 (Anesthetics, Local) RN - 7IO5LYA57N (Ropivacaine) SB - D SB - IM MH - Aged MH - Amides MH - *Analgesia MH - Anesthetics, Local MH - *Chronic Pain MH - Female MH - Humans MH - Pain Measurement MH - Prospective Studies MH - Ropivacaine OTO - NOTNLM OT - Local anesthetic OT - Molar extraction OT - Outcome OT - Ropivacaine EDAT- 2019/07/22 06:00 MHDA- 2020/07/14 06:00 CRDT- 2019/07/22 06:00 PHST- 2019/05/07 00:00 [received] PHST- 2019/07/02 00:00 [revised] PHST- 2019/07/08 00:00 [accepted] PHST- 2019/07/22 06:00 [pubmed] PHST- 2020/07/14 06:00 [medline] PHST- 2019/07/22 06:00 [entrez] AID - S2468-7855(19)30170-3 [pii] AID - 10.1016/j.jormas.2019.07.005 [doi] PST - ppublish SO - J Stomatol Oral Maxillofac Surg. 2020 Apr;121(2):113-117. doi: 10.1016/j.jormas.2019.07.005. Epub 2019 Jul 18. PMID- 27552838 OWN - NLM STAT- MEDLINE DCOM- 20170627 LR - 20170627 IS - 1878-3554 (Electronic) IS - 0099-2399 (Linking) VI - 42 IP - 10 DP - 2016 Oct TI - Uncontrolled Removal of Dentin during In Vitro Ultrasonic Irrigant Activation in Curved Root Canals. PG - 1545-9 LID - S0099-2399(16)30417-4 [pii] LID - 10.1016/j.joen.2016.07.006 [doi] AB - INTRODUCTION: The aim of this study was to examine the effect of file type and activation time on the uncontrolled removal of dentin during in vitro ultrasonic irrigant activation in prepared curved root canals. METHODS: Seventy-two curved mesial root canals of human mandibular molars were prepared to size 35/.04 taper. The specimens were randomly allocated to 4 groups (n = 18). Two milliliters of 2% sodium hypochlorite were delivered 3 times to each root canal, and the irrigant was ultrasonically activated every time for 10 seconds at 35% power either by a ultrasonic K-file (group A), an Irrisafe file (Acteon Satelec, Merignac, France) (group B), or a smooth wire (group C). The same specimens also received further activation continuously for another 30 seconds. No activation took place in group D. Specimens were scanned by micro-computed tomographic imaging before and after preparation and after the first and second activation period. Scans were coregistered and segmented, and the amount of dentin removed during activation was quantified by morphological operations. Results were analyzed by nonparametric statistical tests (α = 0.05). RESULTS: Defects with a maximum depth of 0.18 mm were identified. Both the type of file and activation time affected the removal of dentin (P ≤ .002 and P ≤ .031, respectively). K-files removed more dentin than Irrisafe files and smooth wires in the coronal and middle third. All files removed comparable amounts in the apical third. CONCLUSIONS: All 3 types of files may result in uncontrolled removal of dentin. A longer activation time may increase this effect. CI - Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. FAU - Retsas, Anastasios AU - Retsas A AD - Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. FAU - Koursoumis, Anastasios AU - Koursoumis A AD - Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. FAU - Tzimpoulas, Nestor AU - Tzimpoulas N AD - Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. FAU - Boutsioukis, Christos AU - Boutsioukis C AD - Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. Electronic address: c.boutsioukis@acta.nl. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160821 PL - United States TA - J Endod JT - Journal of endodontics JID - 7511484 RN - 0 (Root Canal Irrigants) RN - DY38VHM5OD (Sodium Hypochlorite) SB - D MH - Dental Instruments MH - Dental Pulp Cavity MH - Dentin/*anatomy & histology/pathology MH - Humans MH - Molar/anatomy & histology/diagnostic imaging MH - Root Canal Irrigants/administration & dosage/*adverse effects MH - Root Canal Preparation/adverse effects/instrumentation/*methods MH - Sodium Hypochlorite/pharmacology MH - Therapeutic Irrigation/methods MH - Ultrasonic Therapy/*adverse effects/instrumentation/methods OTO - NOTNLM OT - Dentin OT - Irrisafe OT - K-file OT - micro–computed tomography OT - smooth wire OT - ultrasonic activation EDAT- 2016/08/25 06:00 MHDA- 2017/06/28 06:00 CRDT- 2016/08/25 06:00 PHST- 2016/04/25 00:00 [received] PHST- 2016/06/28 00:00 [revised] PHST- 2016/07/11 00:00 [accepted] PHST- 2016/08/25 06:00 [entrez] PHST- 2016/08/25 06:00 [pubmed] PHST- 2017/06/28 06:00 [medline] AID - S0099-2399(16)30417-4 [pii] AID - 10.1016/j.joen.2016.07.006 [doi] PST - ppublish SO - J Endod. 2016 Oct;42(10):1545-9. doi: 10.1016/j.joen.2016.07.006. Epub 2016 Aug 21. PMID- 9569795 OWN - NLM STAT- MEDLINE DCOM- 19980601 LR - 20131121 IS - 1018-5992 (Print) IS - 1018-5992 (Linking) VI - 2 IP - 4 DP - 1997 Sep TI - Postoperative pain control by single doses of piroxicam administered sublingually and aspirin. PG - 658-64 AB - The objective of this study is to evaluate and compare the analgesic efficacy of Piroxicam Fast Dissolving Dosage Formulation (FDDF) administered sublingually either preoperatively or postoperatively with that of aspirin and placebo. Hundred patients, undergoing surgical removal of mandibular third molars were given sublingually either piroxicam FDDF 40 mg or placebo or aspirin 500 mg according to a double blind experimental model. Pain scores and pain relief was recorded hourly for six hours following the operation. Rescue analgesics used during the trial and overall assessment of the drug were recorded at the end of six hours. Scores were evaluated statistically by student t test. Piroxicam FDDF was significantly (p < 0.05) more effective than aspirin and placebo for all variables, and less rescue analgesics were required in patients receiving piroxicam preoperatively. It was concluded that single doses of piroxicam FDDF administered sublingually either preoperatively or postoperatively appeared to be effective analgesic for the control of pain after third molar surgery with no side effects. FAU - Alpaslan, C AU - Alpaslan C AD - Gazi University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara, Türkiye. FAU - Alpaslan, G AU - Alpaslan G FAU - Uğar, D AU - Uğar D LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - Turkey TA - J Marmara Univ Dent Fac JT - Journal of Marmara University Dental Faculty JID - 9114162 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - R16CO5Y76E (Aspirin) SB - D MH - Administration, Sublingual MH - Adolescent MH - Adult MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage MH - Aspirin/*administration & dosage MH - Female MH - Humans MH - Male MH - Middle Aged MH - Pain Measurement/statistics & numerical data MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*administration & dosage MH - Single-Blind Method MH - Tooth Extraction EDAT- 1998/05/07 00:00 MHDA- 1998/05/07 00:01 CRDT- 1998/05/07 00:00 PHST- 1998/05/07 00:00 [pubmed] PHST- 1998/05/07 00:01 [medline] PHST- 1998/05/07 00:00 [entrez] PST - ppublish SO - J Marmara Univ Dent Fac. 1997 Sep;2(4):658-64. PMID- 32318443 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 9 IP - 2 DP - 2020 Feb TI - Comparative evaluation of efficacy and latency of twin mix vs 2% lignocaine HCL with 1:80000 epinephrine in surgical removal of impacted mandibular third molar. PG - 904-908 LID - 10.4103/jfmpc.jfmpc_998_19 [doi] AB - INTRODUCTION: A prospective randomized double-blind controlled trial was conducted to evaluate the latency and duration of pterygomandibular nerve block with a mixture of 1.8 ml 2% lignocaine with 1:80,000 epinephrine and 1 ml of 4 mg dexamethasone and its impact on postoperative sequelae after surgical extraction of impacted mandibular third molars. MATERIALS AND METHODS: This study was conducted in 40 subjects referred to the department of oral and maxillofacial surgery; they were divided into 20 subjects each in group A and B with the age range of 18-72 years planned for elective surgical removal of unilateral impacted mandibular third molar. Each patient was randomly selected to receive anesthesia using 1.8 ml 2% lignocaine with 1:80,000 epinephrine in group A or 2.8 ml twin mix (1.8 ml 2% lignocaine with 1:80,000 epinephrine + 1 ml 4 mg dexamethasone) in group B. After injection of the anesthetic solution, the time to anesthetic effect, duration of anesthesia from initial patient perception of the anesthetic effect to the time when the effect subsides, need to reanesthetize the surgical site were recorded, and 10-point visual analog scale (VAS) was used to subjectively assess the overall pain intensity while injecting the study drug, during surgery, and in the postoperative period. RESULTS: Mean VAS value for pain on local anesthetic injection was less in twin-mix group. The time of onset of the local anesthetic was significantly less for the study group T, 51.35 ± 7.15 s when compared with patients in study group C (P less than 0.0001). The duration of soft tissue anesthesia was longer for all the patients in the study group T. On comparative evaluation between study group C and study group T, patients in the control group had more severe swelling and reduction in mouth opening in the postoperative period. CONCLUSION: The addition of dexamethasone to lignocaine and its administration as an intraspace injection significantly shortens the latency and prolongs the duration of the soft tissue anesthesia, with improved quality of life in the postoperative period after surgical extraction of mandibular third molars. CI - Copyright: © Journal of Family Medicine and Primary Care. FAU - Sahu, Swati AU - Sahu S AD - Department of OMFS, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India. FAU - Patley, Abhishek AU - Patley A AD - Department of OMFS, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India. FAU - Kharsan, Vinay AU - Kharsan V AD - Department of OMFS, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India. FAU - Madan, R S AU - Madan RS AD - Department of Oral and Maxillofacial Surgery, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India. FAU - Manjula, V AU - Manjula V AD - Department of OMFS, K.G.F College of Dental Sciences and Hospital, Kolar, Karnataka, India. FAU - Tiwari, Rahul Vinay Chandra AU - Tiwari RVC AD - Department of Oral and Maxillofacial Surgery, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India. LA - eng PT - Journal Article DEP - 20200228 TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC7113948 OTO - NOTNLM OT - Dexamethasone OT - impacted tooth OT - lignocaine OT - twin mix COIS- There are no conflicts of interest. EDAT- 2020/04/23 06:00 MHDA- 2020/04/23 06:01 CRDT- 2020/04/23 06:00 PHST- 2019/11/11 00:00 [received] PHST- 2019/12/27 00:00 [revised] PHST- 2020/01/08 00:00 [accepted] PHST- 2020/04/23 06:00 [entrez] PHST- 2020/04/23 06:00 [pubmed] PHST- 2020/04/23 06:01 [medline] AID - JFMPC-9-904 [pii] AID - 10.4103/jfmpc.jfmpc_998_19 [doi] PST - epublish SO - J Family Med Prim Care. 2020 Feb 28;9(2):904-908. doi: 10.4103/jfmpc.jfmpc_998_19. eCollection 2020 Feb. PMID- 2883698 OWN - NLM STAT- MEDLINE DCOM- 19870527 LR - 20190726 IS - 0033-3158 (Print) IS - 0033-3158 (Linking) VI - 91 IP - 2 DP - 1987 TI - Benzodiazepine--induced event amnesia following a stressful surgical procedure. PG - 244-7 AB - In a randomised, double-blind, parallel groups study, 40 patients undergoing surgical removal of impacted third molar teeth received either midazolam 15 mg orally followed at 35 min by intravenous saline or oral placebo followed by intravenous diazepam 10 mg (Diazemuls). Episodic (event) memory was assessed by showing patients photographs of dental and neutral objects both before and after sedation and by testing subsequent recognition at 1 week. Recall of actual surgical events was assessed by questionnaire. Both treatments induced significant amnesia for visual stimuli and for surgical events. However, the degree of amnesia was more profound for artificial stimuli and no relationship was found between the extent of amnesia for the two types of event. Drilling of bone was found to provoke the greatest cardiovascular stress response and a significant relationship was found between the degree of cardiovascular activation and subsequent memory for drilling. It is concluded that the extent of benzodiazepine-induced event-amnesia may be modified by cognitive factors and especially by the extent to which the event is cognitively encoded and elaborated. FAU - O'Boyle, C A AU - O'Boyle CA FAU - Barry, H AU - Barry H FAU - Fox, E AU - Fox E FAU - Harris, D AU - Harris D FAU - McCreary, C AU - McCreary C LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Psychopharmacology (Berl) JT - Psychopharmacology JID - 7608025 RN - 0 (Anti-Anxiety Agents) RN - Q3JTX2Q7TU (Diazepam) RN - R60L0SM5BC (Midazolam) SB - IM MH - Adult MH - Amnesia/*chemically induced MH - Anti-Anxiety Agents/*pharmacology MH - Blood Pressure/drug effects MH - Diazepam/pharmacology MH - Female MH - Heart Rate/drug effects MH - Humans MH - Male MH - Midazolam/pharmacology MH - Stress, Physiological/*psychology MH - *Tooth Extraction EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] AID - 10.1007/BF00217072 [doi] PST - ppublish SO - Psychopharmacology (Berl). 1987;91(2):244-7. doi: 10.1007/BF00217072. PMID- 29652002 OWN - NLM STAT- MEDLINE DCOM- 20181113 LR - 20181113 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 29 IP - 2 DP - 2018 Mar-Apr TI - Evaluation of bioflavonoids on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin. PG - 133-136 LID - 10.4103/ijdr.IJDR_284_17 [doi] AB - AIM: This study aims to evaluate the effect of two bioflavonoids (epigallocatechin-3-gallate [EGCG] and catechin) and a protein inhibitor (chlorhexidine [CHX]) on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin. MATERIALS AND METHODS: The occlusal surfaces of 96 mandibular human third molar teeth specimens were ground after removal of the excess tissues, to expose the middle dentin. The dentin specimens were randomly allocated into four groups, each consisting of 24 teeth (n = 24) according to the application of the enzyme inhibitor. The adhesive system used in this study was Adper easy bond, a self-etch adhesive system, and Adper Single Bond 2, a total-etch adhesive system. Microtensile bond strength testing was conducted using thermocycler 2000, Heto-Holten A/S. RESULTS: All the three enzyme inhibitors increase the bond strength values of the resin-dentin interphase when used during dentin bonding. The EGCG enzyme inhibitor has shown the highest immediate bond strength to dentin when used with both the adhesive systems. FAU - Kalaiselvam, Rajeswari AU - Kalaiselvam R AD - Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India. FAU - Ganesh, Arathi AU - Ganesh A AD - Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India. FAU - Rajan, Mathan AU - Rajan M AD - Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India. FAU - Kandaswamy, Deivanayagam AU - Kandaswamy D AD - Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 RN - 0 (Adper single bond 2) RN - 0 (Dental Cements) RN - 8R1V1STN48 (Catechin) RN - BQM438CTEL (epigallocatechin gallate) RN - R4KO0DY52L (Chlorhexidine) SB - D MH - Catechin/*analogs & derivatives/*pharmacology MH - Chlorhexidine/*pharmacology MH - *Dental Bonding/methods MH - Dental Cements/therapeutic use MH - *Dental Etching/methods MH - Dental Stress Analysis MH - Dentin/*drug effects MH - Humans MH - Molar MH - Tensile Strength/drug effects OTO - NOTNLM OT - Adhesive systems OT - bioflavonoids OT - microtensile bond strength COIS- There are no conflicts of interest EDAT- 2018/04/14 06:00 MHDA- 2018/11/14 06:00 CRDT- 2018/04/14 06:00 PHST- 2018/04/14 06:00 [entrez] PHST- 2018/04/14 06:00 [pubmed] PHST- 2018/11/14 06:00 [medline] AID - IndianJDentRes_2018_29_2_133_229611 [pii] AID - 10.4103/ijdr.IJDR_284_17 [doi] PST - ppublish SO - Indian J Dent Res. 2018 Mar-Apr;29(2):133-136. doi: 10.4103/ijdr.IJDR_284_17. PMID- 2391397 OWN - NLM STAT- MEDLINE DCOM- 19901004 LR - 20190824 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 30 IP - 7 DP - 1990 Jul TI - Analgesic efficacy of acetaminophen sustained release. PG - 654-9 AB - The analgesic efficacy of acetaminophen sustained release (SR) and acetaminophen immediate plus sustained release (IR + SR) was evaluated in 200 outpatients with pain after oral surgery. Under double-blind conditions SR high dose (2000 mg) or low dose (1000 mg), IR + SR high dose (500 + 1500 mg) or low dose (250 + 750 mg), or acetaminophen standard tablet high dose (1000 mg) or low dose (500 mg) were randomly administered after removal of a lower third molar. The hourly pain intensity was rated on a visual analog scale during 12 hours. The efficacy was based on peak effect (maximum pain intensity difference in percent), pain reduction (mean percentage pain intensity difference), duration of effect (time to remedication) and pain reduction index (pain reduction multiplied by duration of effect). Pain reduction was 37% with the 500-mg tablet and 54% with SR 2000 mg. The peak effect increased from 53% after 1.9 hours for the 500-mg tablet to 67% after 2.6 hours for SR 2000 mg. The SR formulation significantly increased the duration of effect without reduction in peak effect. FAU - Ström, C AU - Ström C AD - Department of Oral Surgery, Central Hospital, Falun, Sweden. FAU - Forsberg, O AU - Forsberg O FAU - Quiding, H AU - Quiding H FAU - Engevall, S AU - Engevall S FAU - Larsson, O AU - Larsson O LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Delayed-Action Preparations) RN - 362O9ITL9D (Acetaminophen) SB - IM MH - *Acetaminophen MH - Adult MH - Ambulatory Care MH - *Analgesia MH - Delayed-Action Preparations MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain/*drug therapy MH - Random Allocation MH - Time Factors MH - *Tooth Extraction EDAT- 1990/07/01 00:00 MHDA- 1990/07/01 00:01 CRDT- 1990/07/01 00:00 PHST- 1990/07/01 00:00 [pubmed] PHST- 1990/07/01 00:01 [medline] PHST- 1990/07/01 00:00 [entrez] AID - 10.1002/j.1552-4604.1990.tb01869.x [doi] PST - ppublish SO - J Clin Pharmacol. 1990 Jul;30(7):654-9. doi: 10.1002/j.1552-4604.1990.tb01869.x. PMID- 24596629 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140305 LR - 20200930 IS - 1989-5488 (Print) IS - 1989-5488 (Electronic) IS - 1989-5488 (Linking) VI - 6 IP - 1 DP - 2014 Feb TI - A comparison of two anesthesia methods for the surgical removal of maxillary third molars: PSA nerve block technique vs. local infiltration technique. PG - e12-6 LID - 10.4317/jced.51199 [doi] AB - OBJECTIVES: The purpose of this study was to compare the effect of PSA block injection with infiltration technique regarding local anesthesia for surgical extraction of upper third molar. MATERIAL AND METHODS: A prospective, intra individual, single-blind randomized controlled trial was designed to study the severity of pain during injection and after surgical extraction of the bilaterally and symmetrically similar upper third molar in a total of 53 patients, in addition to evaluating the need to repeat the injection and requirement of post operative anti-inflammatory tablets. RESULT: Although the average pain score for all studied times in PSA side was lower than the average pain score in infiltration technique, repeated statistical measures demonstrated that no significant pain reduction occurred in the two techniques. CONCLUSION: The both tested methods have the same statistic equivalence for the surgical extraction of maxillary third molars. Key words:Surgical extraction, maxillary third molars, PSA block, infiltration. FAU - Al-Delayme, Ra Ed Ma AU - Al-Delayme RE AD - B.D.S, S.OMFS.S, C.A.B.OMFS, M.F.D. R.C.S. I., M.O.M.S. R.C.P.S .G, F.F.D (OSOM) R.C.S.I. Dean of The Faculty of Dentistry, Dijla University College, Baghdad, Iraq ; B.D.S, S.OMFS.S, C.A.B.OMFS, M.F.D. R.C.S. I., M.O.M.S. R.C.P.S .G, F.F.D (OSOM) R.C.S. I. Senior Specialist at Oral and Maxillofacial Surgery Dept., AL-Yarmuk Teaching Hospital, Baghdad, Iraq. LA - eng PT - Journal Article DEP - 20140201 TA - J Clin Exp Dent JT - Journal of clinical and experimental dentistry JID - 101603132 PMC - PMC3935899 COIS- Conflict of interest statement: The authors have declared that no conflict of interest exist. EDAT- 2014/03/07 06:00 MHDA- 2014/03/07 06:01 CRDT- 2014/03/06 06:00 PHST- 2013/07/02 00:00 [received] PHST- 2013/11/21 00:00 [accepted] PHST- 2014/03/06 06:00 [entrez] PHST- 2014/03/07 06:00 [pubmed] PHST- 2014/03/07 06:01 [medline] AID - 51199 [pii] AID - 10.4317/jced.51199 [doi] PST - epublish SO - J Clin Exp Dent. 2014 Feb 1;6(1):e12-6. doi: 10.4317/jced.51199. eCollection 2014 Feb. PMID- 3743627 OWN - NLM STAT- MEDLINE DCOM- 19861008 LR - 20190813 IS - 0031-6970 (Print) IS - 0031-6970 (Linking) VI - 30 IP - 4 DP - 1986 TI - Comparative efficacy of soluble aspirin and aspirin tablets in postoperative dental pain. PG - 495-8 AB - The efficacy of single doses (1.2 g) of soluble aspirin and aspirin tablets was determined in a randomised, placebo-controlled, double-blind, parallel study in 90 patients (45 females) with postoperative pain after removal of impacted lower third molars. Also investigated was the relationship between plasma aspirin esterase activity and overall pain scores after both aspirin preparations. Patients reported significantly less pain (p less than 0.001) after treatment with aspirin than after treatment with placebo. However, patients receiving soluble aspirin reported both an earlier onset and a longer duration of pain relief than those who received aspirin tablets. A significant correlation was observed between plasma aspirin esterase activity and overall pain scores after both soluble aspirin (r = 0.57, p less than 0.01) and aspirin tablets (r = 0.51, p less than 0.02). It is concluded that soluble aspirin is the preferred aspirin formulation for treating postoperative pain after third molar surgery and that plasma aspirin esterase activity is determinant of a patient's analgesic response to aspirin in postoperative dental pain. FAU - Seymour, R A AU - Seymour RA FAU - Williams, F M AU - Williams FM FAU - Luyk, N M AU - Luyk NM FAU - Boyle, M A AU - Boyle MA FAU - Whitfield, P M AU - Whitfield PM FAU - Nicholson, E AU - Nicholson E FAU - Booth, P W AU - Booth PW FAU - Rawlins, M D AU - Rawlins MD LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Solutions) RN - 0 (Tablets) RN - EC 3.1.1.- (Carboxylic Ester Hydrolases) RN - EC 3.1.1.- (acetylsalicylic acid hydrolase) RN - R16CO5Y76E (Aspirin) SB - IM MH - Adolescent MH - Adult MH - Aspirin/administration & dosage/*therapeutic use MH - Carboxylic Ester Hydrolases/*blood MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain, Postoperative/*drug therapy/enzymology MH - Random Allocation MH - Solutions MH - Tablets MH - Tooth Extraction EDAT- 1986/01/01 00:00 MHDA- 1986/01/01 00:01 CRDT- 1986/01/01 00:00 PHST- 1986/01/01 00:00 [pubmed] PHST- 1986/01/01 00:01 [medline] PHST- 1986/01/01 00:00 [entrez] AID - 10.1007/BF00607968 [doi] PST - ppublish SO - Eur J Clin Pharmacol. 1986;30(4):495-8. doi: 10.1007/BF00607968. PMID- 3468226 OWN - NLM STAT- MEDLINE DCOM- 19870311 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 45 IP - 2 DP - 1987 Feb TI - Effect of pretreatment with acetaminophen-propoxyphene for oral surgery pain. PG - 99-103 AB - To determine the effect of pretreatment and multiple doses on postsurgical pain, a study of the relative analgesic efficacy of placebo, acetaminophen 650 mg, and propoxyphene napsylate 100 mg alone and in combination was conducted. Forty-five patients undergoing surgical removal of impacted third molar teeth under local anesthesia were randomly allocated to the four treatment regimens under double-blind conditions. The first oral dose was administered one hour preoperatively and the second dose when the pain became moderate or severe, following the dissipation of the local anesthesia. Pain intensity and pain relief were assessed using standard verbal descriptor scales at 30 minutes and hourly for four hours after the postoperative dose. Measures of total effect, peak effect and duration of their effect were derived from these descriptors. Acetaminophen was no better than placebo. For peak and total effects, propoxyphene alone and the propoxyphene-acetaminophen combination were substantially superior to both placebo and acetaminophen alone. Duration of analgesia was also significantly longer with both propoxyphene-containing treatments. No side effects were reported. The results suggest that pretreatment with a narcotic agonist markedly improves postoperative analgesia. FAU - Liashek, P Jr AU - Liashek P Jr FAU - Desjardins, P J AU - Desjardins PJ FAU - Triplett, R G AU - Triplett RG LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Drug Combinations) RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - S2F83W92TK (Dextropropoxyphene) SB - AIM SB - D SB - IM MH - *Acetaminophen/*administration & dosage MH - Adolescent MH - Adult MH - Dextropropoxyphene/*administration & dosage MH - Double-Blind Method MH - Drug Administration Schedule MH - Drug Combinations MH - Humans MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Placebos MH - *Premedication MH - Time Factors MH - Tooth, Impacted/surgery EDAT- 1987/02/01 00:00 MHDA- 2001/03/28 10:01 CRDT- 1987/02/01 00:00 PHST- 1987/02/01 00:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1987/02/01 00:00 [entrez] AID - 0278-2391(87)90398-3 [pii] AID - 10.1016/0278-2391(87)90398-3 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1987 Feb;45(2):99-103. doi: 10.1016/0278-2391(87)90398-3. PMID- 293045 OWN - NLM STAT- MEDLINE DCOM- 19800226 LR - 20161020 IS - 0036-7702 (Print) IS - 0036-7702 (Linking) VI - 89 IP - 5 DP - 1979 May TI - [Efficiency of systemic prophylatic antibiotics in the surgical removal of lower widsom teeth]. PG - 458-66 AB - The efficiency of prophylactically given systemic antibiotics was examined in a double-blind study on 142 patients on an ambulatory basis. It was found that the application of antibiotics do not significantly lower the rate of postoperative infections after the surgical removal of lower third molars. FAU - Osborn, J F AU - Osborn JF FAU - Jaques, W A AU - Jaques WA FAU - Thalmann, R AU - Thalmann R FAU - Spiessl, B AU - Spiessl B LA - ger PT - Clinical Trial PT - Controlled Clinical Trial PT - English Abstract PT - Journal Article TT - Die Wirksamkeit systemischer Antiobiotikaprophylaxe bei der operativen Entfernung unterer Weisheitszähne. PL - Switzerland TA - SSO Schweiz Monatsschr Zahnheilkd JT - Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie JID - 20520010R RN - 0 (Anti-Bacterial Agents) RN - 7C782967RD (Ampicillin) RN - FDM21QQ344 (Cephacetrile) RN - OBN7UDS42Y (Cephalexin) SB - D SB - IM MH - Ampicillin/therapeutic use MH - Anti-Bacterial Agents/*therapeutic use MH - Bacterial Infections/*prevention & control MH - Cephacetrile/therapeutic use MH - Cephalexin/therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Molar/*surgery MH - Mouth/surgery MH - Postoperative Complications/prevention & control MH - Tooth Extraction/*adverse effects EDAT- 1979/05/01 00:00 MHDA- 1979/05/01 00:01 CRDT- 1979/05/01 00:00 PHST- 1979/05/01 00:00 [pubmed] PHST- 1979/05/01 00:01 [medline] PHST- 1979/05/01 00:00 [entrez] PST - ppublish SO - SSO Schweiz Monatsschr Zahnheilkd. 1979 May;89(5):458-66. PMID- 25778933 OWN - NLM STAT- MEDLINE DCOM- 20160120 LR - 20181113 IS - 1432-1041 (Electronic) IS - 0031-6970 (Linking) VI - 71 IP - 5 DP - 2015 May TI - Combination paracetamol and ibuprofen for pain relief after oral surgery: a dose ranging study. PG - 579-87 LID - 10.1007/s00228-015-1827-x [doi] AB - PURPOSE: Combined paracetamol and ibuprofen has been shown to be more effective than either constituent alone for acute pain in adults, but the dose-response has not been confirmed. The aim of this study was to define the analgesic dose-response relationship of different potential doses of a fixed dose combination containing paracetamol and ibuprofen after third molar surgery. METHODS: Patients aged 16 to 60 years with moderate or severe pain after the removal of at least two impacted third molars were randomised to receive double-blind study medication as two tablets every 6 h for 24 h of either of the following: two tablet, combination full dose (paracetamol 1000 mg and ibuprofen 300 mg); one tablet, combination half dose (paracetamol 500 mg and ibuprofen 150 mg); half a tablet, combination quarter dose (paracetamol 250 mg and ibuprofen 75 mg); or placebo. The primary outcome measure was the time-adjusted summed pain intensity difference over 24 h (SPID 24) calculated from the 100-mm VAS assessments collected over multiple time points for the study duration. RESULTS: Data from 159 patients were included in the analysis. Mean (SD) time-adjusted SPID over 24 h were full-dose combination 20.1 (18.0), half dose combination 20.4 (20.8), quarter dose combination 19.3 (20.0) and placebo 6.6 (19.8). There was a significant overall effect of dose (p = 0.002) on the primary outcome. Planned pairwise comparisons showed that all combination dose groups were superior to placebo (full dose vs. placebo p = 0.004, half dose vs. placebo p = 0.002, quarter dose vs. placebo p = 0.002). The overall effect of dose was also significant for maximum VAS pain intensity score (p = 0.048), response rate (p = 0.0094), percentage of participants requiring rescue (p = 0.025) and amount of rescue (p < 0.001). No significant dose effect was found for time to peak reduction in VAS or time to meaningful pain relief. The majority of adverse events recorded were of mild (52.75%) or moderate (40.16%) severity and not related (30.7%) or unlikely related (57.5%) to the study medication. CONCLUSION: All doses of the combination provide safe superior pain relief to placebo in adult patients following third molar removal surgery. FAU - Atkinson, Hartley C AU - Atkinson HC AD - AFT Pharmaceuticals Ltd, Takapuna, P O Box 33-203, Auckland, 0740, New Zealand. FAU - Currie, John AU - Currie J FAU - Moodie, John AU - Moodie J FAU - Carson, Simon AU - Carson S FAU - Evans, Steven AU - Evans S FAU - Worthington, James P AU - Worthington JP FAU - Steenberg, Leon J AU - Steenberg LJ FAU - Bisley, Eileen AU - Bisley E FAU - Frampton, Chris AU - Frampton C LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20150318 PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Acetaminophen/*administration & dosage/adverse effects/therapeutic use MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/*administration & dosage/adverse effects/therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/*administration & dosage/adverse effects/therapeutic use MH - Male MH - Middle Aged MH - Pain, Postoperative/*drug therapy MH - Tooth Extraction/*adverse effects MH - Treatment Outcome MH - Young Adult EDAT- 2015/03/18 06:00 MHDA- 2016/01/21 06:00 CRDT- 2015/03/18 06:00 PHST- 2014/11/27 00:00 [received] PHST- 2015/02/15 00:00 [accepted] PHST- 2015/03/18 06:00 [entrez] PHST- 2015/03/18 06:00 [pubmed] PHST- 2016/01/21 06:00 [medline] AID - 10.1007/s00228-015-1827-x [doi] PST - ppublish SO - Eur J Clin Pharmacol. 2015 May;71(5):579-87. doi: 10.1007/s00228-015-1827-x. Epub 2015 Mar 18. PMID- 11465977 OWN - NLM STAT- MEDLINE DCOM- 20010913 LR - 20151119 IS - 1090-3801 (Print) IS - 1090-3801 (Linking) VI - 5 IP - 2 DP - 2001 TI - Pregabalin in patients with postoperative dental pain. PG - 119-24 AB - Pregabalin is an analogue of the inhibitory neurotransmitter gamma-aminobutyric acid. In preclinical models, it has shown activity as an analgesic agent. A randomized, double-blind, placebo-controlled, parallel-group trial was undertaken to compare pregabalin to placebo and 400 mg of ibuprofen using a dental pain model. Study medication was administered postoperatively to patients who had undergone elective surgery to remove one or two third molars, at least one of which was mandibular and fully or partially impacted in bone. The study was conducted in the UK at a single centre and evaluated pregabalin at doses of 50 and 300 mg. Primary efficacy parameters included pain relief (PR), pain intensity difference (PID), pain relief intensity difference (PRID), time to onset of analgesia, and duration of analgesia. The patient's global impression of the study medication was used as a secondary efficacy parameter. Efficacy data were evaluated for the intent-to-treat (ITT) population, defined as all randomized patients who took study medication. Results showed that there were statistically significant differences in PR, PID, and PRID between the 300-mg pregabalin group and placebo. In addition, the 300-mg pregabalin group had a significantly longer duration of analgesia than the ibuprofen group and had the highest score on the patient global impression of study medication. Adverse events were reported more frequently in the pregabalin 300-mg group. Pregabalin appears to have significant analgesic properties in the third molar extraction model. Further research is needed to confirm these findings. CI - Copyright 2001 European Federation of Chapters of the International Association for the study of pain. FAU - Hill, C M AU - Hill CM AD - Department of Oral Surgery, University Hospital of Wales, Cardiff, UK. FAU - Balkenohl, M AU - Balkenohl M FAU - Thomas, D W AU - Thomas DW FAU - Walker, R AU - Walker R FAU - Mathé, H AU - Mathé H FAU - Murray, G AU - Murray G LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Eur J Pain JT - European journal of pain (London, England) JID - 9801774 RN - 0 (Analgesics, Non-Narcotic) RN - 0 (Anticonvulsants) RN - 55JG375S6M (Pregabalin) RN - 56-12-2 (gamma-Aminobutyric Acid) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Adolescent MH - Adult MH - Analgesics, Non-Narcotic/administration & dosage MH - Anesthesia, Local MH - Anticonvulsants/*administration & dosage MH - Double-Blind Method MH - Female MH - Humans MH - Ibuprofen/administration & dosage MH - Male MH - Middle Aged MH - Pain, Postoperative/*drug therapy MH - Pregabalin MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - gamma-Aminobutyric Acid/*administration & dosage/analogs & derivatives EDAT- 2001/07/24 10:00 MHDA- 2001/09/14 10:01 CRDT- 2001/07/24 10:00 PHST- 2001/07/24 10:00 [pubmed] PHST- 2001/09/14 10:01 [medline] PHST- 2001/07/24 10:00 [entrez] AID - S1090-3801(01)90235-6 [pii] AID - 10.1053/eujp.2001.0235 [doi] PST - ppublish SO - Eur J Pain. 2001;5(2):119-24. doi: 10.1053/eujp.2001.0235. PMID- 8159602 OWN - NLM STAT- MEDLINE DCOM- 19940516 LR - 20201209 IS - 0277-0008 (Print) IS - 0277-0008 (Linking) VI - 14 IP - 1 DP - 1994 Jan-Feb TI - Picenadol in a large multicenter dental pain study. PG - 54-9 AB - STUDY OBJECTIVE: To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. DESIGN: Randomized, double-blind, parallel, dose-response study. SETTING: Four university-based dental clinics. PATIENTS: Four hundred eight adult patients with moderate or severe pain after extraction of one or more impacted molar teeth plus bone removal. INTERVENTIONS: Patients received orally administered single doses of picenadol 15 and 30 mg, codeine phosphate 30 and 90 mg, or placebo. METHODS: Single oral doses of picenadol 15 and 30 mg, an opioid agonist-antagonist, were compared with codeine 30 and 90 mg and placebo in 408 patients with moderate or severe pain from third molar extraction in a randomized, double-blind, parallel study. Assessments were performed for pain intensity, pain relief, and adverse events for up to 6 hours after drug administration. MAIN RESULTS: Picenadol 30 mg and codeine 90 mg were more effective than placebo based on sum of pain intensity differences, total pain relief, peak pain relief, and duration of analgesia (p < 0.05). Compared with placebo, the frequency of adverse events was highest for patients receiving codeine 90 mg (p < 0.05). No patients discontinued due to adverse events, and all such events resolved spontaneously. CONCLUSIONS: Picenadol 22 mg was estimated to be equianalgesic to codeine 60 mg, and picenadol 30 mg was safe in this dental pain model. FAU - Goldstein, D J AU - Goldstein DJ AD - Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. FAU - Brunelle, R L AU - Brunelle RL FAU - George, R E AU - George RE FAU - Cooper, S A AU - Cooper SA FAU - Desjardins, P J AU - Desjardins PJ FAU - Gaston, G W AU - Gaston GW FAU - Jeffers, G E AU - Jeffers GE FAU - Gallegos, L T AU - Gallegos LT FAU - Reynolds, D C AU - Reynolds DC LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 0 (Analgesics) RN - 0 (Piperidines) RN - TV3535QWTJ (picenadol) RN - UX6OWY2V7J (Codeine) SB - IM MH - Adult MH - Analgesics/*therapeutic use MH - Bone and Bones/surgery MH - Codeine/therapeutic use MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Piperidines/*therapeutic use MH - *Tooth Extraction EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] AID - 10.1002/j.1875-9114.1994.tb02789.x [doi] PST - ppublish SO - Pharmacotherapy. 1994 Jan-Feb;14(1):54-9. doi: 10.1002/j.1875-9114.1994.tb02789.x. PMID- 9604731 OWN - NLM STAT- MEDLINE DCOM- 19980803 LR - 20131121 IS - 0251-1649 (Print) IS - 0251-1649 (Linking) VI - 18 IP - 1 DP - 1998 TI - The postoperative analgesic efficacy and safety of piroxicam (FDDF) and naproxen sodium. PG - 21-9 AB - The aim of the present study was to compare the analgesic efficacy of piroxicam-FDDF (fast dissolving dosage form) with naproxen sodium, following bilateral removal of impacted third molars. A double-blind, randomized, crossover, analgesic trial was carried out on 40 patients undergoing surgical removal of one lower third molar at each visit. The analgesic efficacy of a single dose regimen of piroxicam-FDDF (40 mg, Feldene Flash, Pfizer, Turkey) was compared with naproxen sodium (550 mg, Anaprotab, Sanli, Turkey). Pain intensity was measured on a category-rating scale during the 8-h period after drug administration. Each patient evaluated the efficacy of the study medication at 15, 30, 45, 60, 90 and 120 min, and then hourly for up to 8 h of drug ingestion. Additional key efficacy measures were also determined (pain intensity difference [PID], sums of pain intensity difference [SPID], total pain relief [TOTPAR], peak pain relief, number of observations at which pain was half-relieved, overall evaluation of study medication effectiveness, and time to medication with a back-up analgesic). The data were analyzed by paired Student's t-test and one-way analysis of variance (ANOVA). Results are expressed as means +/- SEM, and p < 0.05 was taken as statistically significant. The PID and pain relief scores of the piroxicam-FDDF group were significantly greater than those for the naproxen sodium group at 15, 30, 45 and 60 min (p < 0.01). After 90 min to 8 h, no statistical significance was revealed among the two test groups (p > 0.05). The peak pain relief, maximal analgesic effect, SPID, TOTPAR values, adjusted mean number of observations with pain at least half-relieved, and the final overall evaluation records were all superior for piroxicam-FDDF (p < 0.05). The results of this study clearly show that the analgesic efficacy of piroxicam-FDDF is superior to naproxen sodium in the treatment of pain following oral surgery for the removal of impacted third molars. FAU - Selçuk, E AU - Selçuk E AD - Ege University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Izmir, Turkey. FAU - Gomel, M AU - Gomel M FAU - Apaydin, S AU - Apaydin S FAU - Köse, T AU - Köse T FAU - Tuglular, I AU - Tuglular I LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Switzerland TA - Int J Clin Pharmacol Res JT - International journal of clinical pharmacology research JID - 8110183 RN - 0 (Analgesics) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 57Y76R9ATQ (Naproxen) SB - IM EIN - Int J Clin Pharmacol Res 1998;18(3):151 MH - Adolescent MH - Adult MH - Analgesics/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Naproxen/adverse effects/*therapeutic use MH - Pain Measurement MH - Pain, Postoperative/*drug therapy MH - Piroxicam/adverse effects/*therapeutic use MH - Tooth Extraction/adverse effects EDAT- 1998/05/30 00:00 MHDA- 1998/05/30 00:01 CRDT- 1998/05/30 00:00 PHST- 1998/05/30 00:00 [pubmed] PHST- 1998/05/30 00:01 [medline] PHST- 1998/05/30 00:00 [entrez] PST - ppublish SO - Int J Clin Pharmacol Res. 1998;18(1):21-9. PMID- 17448224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20070813 LR - 20181113 IS - 1748-5908 (Electronic) IS - 1748-5908 (Linking) VI - 2 DP - 2007 Apr 20 TI - A cluster randomised controlled trial in primary dental care based intervention to improve professional performance on routine oral examinations and the management of asymptomatic impacted third molars: study protocol. PG - 12 AB - BACKGROUND: Routine oral examination (ROE) refers to periodic monitoring of the general and oral health status of patients. In most developed Western countries a decreasing prevalence of oral diseases underpins the need for a more individualised approach in assigning individualised recall intervals for regular attendees instead of systematic fixed intervals. From a quality-of-care perspective, the effectiveness of the widespread prophylactic removal of mandibular impacted asymptomatic third molars (MIM) in adolescents and adults is also questionable. Data on the effectiveness of appropriate interventions to tackle such problems, and for promoting continuing professional development in oral health care are rare. METHODS/DESIGN: This study is a cluster randomised controlled trial with groups of GDPs as the unit of randomisation. The aim is to determine the effectiveness and efficiency of small group quality improvement on professional decision-making of general dental practitioners (GDPs) in daily practice. Six peer groups ('IQual-groups') shall be randomised either to the intervention arm I or arm II. Groups of GDPs allocated to either of these arms act as each other's control group. An IQual peer group consists of eight to ten GDPs who meet in monthly structured sessions scheduled for discussion on practice-related topics. GDPs in both trial arms receive recently developed evidence-based clinical practice guidelines (CPG) on ROE or MIM. The implementation strategy consists of one interactive IQual group meeting of two to three hours. In addition, both groups of GDPs receive feedback on personal and group characteristics, and are invited to make use of web-based patient risk vignettes for further individual training on risk assessment policy. Reminders (flow charts) will be sent by mail several weeks after the meeting. The main outcome measure for the ROE intervention arm is the use and appropriateness of individualised risk assessment in assigning recall intervals, and for the MIM-intervention group the use and appropriateness of individualised mandibular impacted third molar risk management. Both groups act as each other's control. Pre-intervention data will be collected in study months one through three. Post-intervention data collection will be performed after nine months. FAU - Mettes, Theodorus G AU - Mettes TG AD - Radboud University Nijmegen Medical Centre, Department of Preventive and Restorative Dentistry, College of Oral Sciences, Nijmegen, The Netherlands. d.mettes@dent.umcn.nl FAU - van der Sanden, Wil J M AU - van der Sanden WJ FAU - Wensing, Michel AU - Wensing M FAU - Grol, Richard P T M AU - Grol RP FAU - Plasschaert, Alphons J M AU - Plasschaert AJ LA - eng PT - Journal Article DEP - 20070420 TA - Implement Sci JT - Implementation science : IS JID - 101258411 PMC - PMC1863426 EDAT- 2007/04/24 09:00 MHDA- 2007/04/24 09:01 CRDT- 2007/04/24 09:00 PHST- 2006/08/04 00:00 [received] PHST- 2007/04/20 00:00 [accepted] PHST- 2007/04/24 09:00 [pubmed] PHST- 2007/04/24 09:01 [medline] PHST- 2007/04/24 09:00 [entrez] AID - 1748-5908-2-12 [pii] AID - 10.1186/1748-5908-2-12 [doi] PST - epublish SO - Implement Sci. 2007 Apr 20;2:12. doi: 10.1186/1748-5908-2-12. PMID- 1543618 OWN - NLM STAT- MEDLINE DCOM- 19920415 LR - 20190718 IS - 0007-0610 (Print) IS - 0007-0610 (Linking) VI - 172 IP - 4 DP - 1992 Feb 22 TI - The use of temazepam elixir in surgical dental sedation: a comparison with intravenous midazolam. PG - 153-7 AB - Out-patients attending for removal of at least one lower third molar were randomly allocated to treatment with temazepam elixir (n = 7) or intravenous midazolam (n = 8), as well as local analgesia. Patients were tested prior to drug administration and at the end of surgery. Both drugs increased heart rate and midazolam also decreased diastolic blood pressure. The two drugs caused significant, equal increases in ratings of sedation, but the reduction of anxiety was significant only for midazolam. There was significant amnesia for material presented after drug administration, as well as for dental events and this was significantly greater for midazolam. The effects of these drugs in dental patients were compared with those in normal volunteers treated in an identical manner, but without oral surgery. The drugs had similar significant cardiovascular and amnesic effects in the volunteers and the same effects on mood ratings, even though volunteers and patients differed in their pretreatment levels of anxiety and discontent. The dentist's ratings of the sedation and operating conditions were excellent in both cases. Thus temazepam elixir provided a useful sedative for oral surgery, avoiding the complications of intravenous administration. However, for equivalent levels of sedation, midazolam had greater anxiolytic and amnesic effects than temazepam. FAU - Skelly, A M AU - Skelly AM AD - Department of Clinical Dental Surgery, Guy's Hospital, London. FAU - Girdler, N M AU - Girdler NM FAU - File, S E AU - File SE LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Br Dent J JT - British dental journal JID - 7513219 RN - CHB1QD2QSS (Temazepam) RN - R60L0SM5BC (Midazolam) SB - D SB - IM MH - Administration, Oral MH - Adult MH - Analysis of Variance MH - Anesthesia, Dental/*methods MH - Anxiety/prevention & control MH - Blood Pressure/drug effects MH - Conscious Sedation/*methods MH - Female MH - Heart Rate/drug effects MH - Humans MH - Injections, Intravenous MH - Male MH - Memory/drug effects MH - Midazolam/administration & dosage/*pharmacology MH - Pain Measurement MH - Patient Satisfaction MH - Random Allocation MH - Temazepam/administration & dosage/*pharmacology EDAT- 1992/02/22 00:00 MHDA- 1992/02/22 00:01 CRDT- 1992/02/22 00:00 PHST- 1992/02/22 00:00 [pubmed] PHST- 1992/02/22 00:01 [medline] PHST- 1992/02/22 00:00 [entrez] AID - 10.1038/sj.bdj.4807798 [doi] PST - ppublish SO - Br Dent J. 1992 Feb 22;172(4):153-7. doi: 10.1038/sj.bdj.4807798. PMID- 2869772 OWN - NLM STAT- MEDLINE DCOM- 19860514 LR - 20190515 IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 58 IP - 4 DP - 1986 Apr TI - Sedation in outpatient oral surgery. Comparison of temazepam by mouth and diazepam i.v. PG - 378-84 AB - In a randomized double-blind, parallel groups study, 39 patients undergoing surgical removal of impacted third molar teeth received either temazepam 40 mg by mouth (as soft gelatin capsules) followed at 35 min by i.v. saline, or oral placebo followed at 35 min by i.v. diazepam 10 mg (Diazemuls). Rapid onset of significant anxiolytic activity and psychomotor depression was seen following temazepam, while the pattern and duration of postoperative sedation measured with standard psychometric tests, were similar for both treatments. Ratings by the surgeon and by the patients indicated that sedation following the two treatments was comparable. No significant cardiovascular complications were found with either treatment. The findings indicate that rapidly acting oral benzodiazepines such as temazepam provide safe, effective alternatives to i.v. diazepam for sedation in outpatients undergoing minor surgical procedures. FAU - O'Boyle, C A AU - O'Boyle CA FAU - Harris, D AU - Harris D FAU - Barry, H AU - Barry H LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Anti-Anxiety Agents) RN - 0 (Hypnotics and Sedatives) RN - CHB1QD2QSS (Temazepam) RN - Q3JTX2Q7TU (Diazepam) SB - IM MH - Administration, Oral MH - Adolescent MH - Adult MH - *Anti-Anxiety Agents/administration & dosage/pharmacology MH - Anxiety/prevention & control MH - *Diazepam/administration & dosage/pharmacology MH - Double-Blind Method MH - Female MH - Hemodynamics/drug effects MH - Humans MH - *Hypnotics and Sedatives MH - Injections, Intravenous MH - Male MH - Patient Acceptance of Health Care MH - Psychomotor Performance/drug effects MH - *Temazepam/administration & dosage/pharmacology MH - Tooth Extraction MH - Tooth, Impacted/*surgery EDAT- 1986/04/01 00:00 MHDA- 1986/04/01 00:01 CRDT- 1986/04/01 00:00 PHST- 1986/04/01 00:00 [pubmed] PHST- 1986/04/01 00:01 [medline] PHST- 1986/04/01 00:00 [entrez] AID - S0007-0912(17)37817-0 [pii] AID - 10.1093/bja/58.4.378 [doi] PST - ppublish SO - Br J Anaesth. 1986 Apr;58(4):378-84. doi: 10.1093/bja/58.4.378. PMID- 15086613 OWN - NLM STAT- MEDLINE DCOM- 20040603 LR - 20131121 IS - 0303-6979 (Print) IS - 0303-6979 (Linking) VI - 31 IP - 5 DP - 2004 May TI - Dentine hypersensitivity: development and evaluation ofamodel in situ to study tubulepatency. PG - 325-35 AB - BACKGROUND AND AIMS: Lesions of dentine hypersensitivity have numerous tubules open at the dentine surface as opposed to non-sensitive dentine where tubules are mostly covered by a smear layer. The present two studies were designed to model both states in situ and evaluate the effects of agents on the model. METHOD: Etched (sensitive) and smeared (non-sensitive) dentine specimens prepared from human third molar teeth were retained in lower buccal acrylic appliances. The results of Study 1 led to the development of a method to ensure tubules were sectioned at right angles. Study 1 was a 5-day period, seven treatment regimens randomised, part blind cross over design involving five subjects. Treatments were 2x day application of a desensitising (SA) or non-desensitising toothpastes (F) or chlorhexidine (CHX) mouthwash with or without drinking orange juice (OJ)(1 l/day). A no treatment group (P) allowed plaque to accumulate. The evaluation of effects was observational by scanning electron microscopy (SEM). Study 2 involved 1 subject, 4 treatments applied once and studied after 0, 6, and 12 h by SEM with image analysis. The 12 h groups were studied with and without imbibing water or OJ. Treatments were two desensitising (SA & SC) and one non-desensitising (F) toothpastes and an in office product (DS). RESULTS: Study 1: Treatment SA resulted in occlusion of tubules an outcome little changed by OJ. Treatment P produced a bio-film, which covered the dentine surface. CHX produced some tubule occlusion in three of the five subjects. F+/-OJ and CHX+OJ had little effect and tubules remained open. For smeared specimens toothpastes and OJ removed the smear layer but SA+/-OJ blocked tubules. P and CHX had no effect on the smear layer. Study 2: At 0 h, tubule occlusion was in order of magnitude DS>or=SA>SC>F. After 6 and 12 h with SA, SC and F some loss of occlusion occurred but not DS. Water and OJ by 12 h decreased occlusion for SA, SC and particularly F. Water and OJ removed virtually all of DS. CONCLUSIONS: The aims of Study 1 were achieved and effect of treatments was not inconsistent with data in vitro. The need for more standardisation of specimens was appreciated and applied in Study 2 to allow image analysis to quantitatively record data. Further use of the model in randomised controlled clinical trials is envisaged. FAU - Banfield, N AU - Banfield N AD - Division of Restorative Dentistry, Dental School, Bristol, UK. FAU - Addy, M AU - Addy M LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Clin Periodontol JT - Journal of clinical periodontology JID - 0425123 RN - 0 (Anti-Infective Agents, Local) RN - 0 (Mouthwashes) RN - 0 (Toothpastes) RN - R4KO0DY52L (Chlorhexidine) SB - D SB - IM MH - Acid Etching, Dental MH - Adult MH - Anti-Infective Agents, Local/therapeutic use MH - Beverages MH - Chlorhexidine/therapeutic use MH - Citrus sinensis MH - Cross-Over Studies MH - Dental Plaque/complications MH - Dentin/*ultrastructure MH - Dentin Sensitivity/*etiology/prevention & control MH - Female MH - Humans MH - Image Processing, Computer-Assisted MH - Male MH - Microscopy, Electron, Scanning MH - Middle Aged MH - Mouthwashes/therapeutic use MH - Single-Blind Method MH - Smear Layer MH - Toothbrushing MH - Toothpastes/therapeutic use EDAT- 2004/04/17 05:00 MHDA- 2004/06/04 05:00 CRDT- 2004/04/17 05:00 PHST- 2004/04/17 05:00 [pubmed] PHST- 2004/06/04 05:00 [medline] PHST- 2004/04/17 05:00 [entrez] AID - CPE488 [pii] AID - 10.1111/j.1600-051X.2004.00488.x [doi] PST - ppublish SO - J Clin Periodontol. 2004 May;31(5):325-35. doi: 10.1111/j.1600-051X.2004.00488.x. PMID- 26872898 OWN - NLM STAT- MEDLINE DCOM- 20171003 LR - 20181202 IS - 1532-1940 (Electronic) IS - 0266-4356 (Linking) VI - 54 IP - 3 DP - 2016 Apr TI - Local heating of the wound with dressings soaked in saline at 42°C can reduce postoperative bleeding: a single-blind, split-mouth, randomised controlled clinical trial. PG - 266-9 LID - S0266-4356(16)00022-X [pii] LID - 10.1016/j.bjoms.2016.01.020 [doi] AB - Control of bleeding is essential during oral procedures. Although various chemical agents have been introduced and tested, hot water dressing has not to our knowledge been assessed before. Studies of operations for epistaxis or sinus conditions have suggested that irrigation with hot water can reduce bleeding, so we hypothesised that it might be effective in reducing bleeding after extraction too. Ten patients who required bilateral extractions took part in this split-mouth, randomised, single-blind, controlled clinical trial. After extraction, sockets were packed with similar gauze dressings soaked in normal saline 4 ml at room temperature (control) and warmed to 42°C (experimental). The extent of bleeding on each side was measured by subtracting the original weight of the gauze from its weight after absorption of blood. The difference between the weights was compared using Student's paired t test (α=0.05, β<0.05). Mean (SD) weights were 22.1(2.2) g and 18.4 (2.5) g in the control and experimental groups, respectively, indicating an 18% reduction in the experimental group (p=0.002). Soaking gauze in normal saline heated to 42°C can reduce bleeding after extraction. CI - Copyright © 2016 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - Haraji, Afshin AU - Haraji A AD - Department of Oral and Maxillofacial Surgery, Faculty Principal, Dental Branch, Islamic Azad University, Tehran, Iran. FAU - Rakhshan, Vahid AU - Rakhshan V AD - Member of the Research Council, Iranian Tissue Engineering and Graft Research Centre, Tehran University of Medical Sciences; Scientific Faculty Member and Lecturer, Department of Dental Anatomy and Morphology, Dental Branch, Islamic Azad University, Tehran, Iran. Electronic address: vahid.rakhshan@gmail.com. FAU - Hosseini, Vasim AU - Hosseini V AD - Dentist in private practice, Tehran, Iran. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160210 PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 451W47IQ8X (Sodium Chloride) SB - D SB - IM MH - *Bandages MH - Heating MH - Humans MH - Mouth MH - *Postoperative Hemorrhage MH - Single-Blind Method MH - Sodium Chloride OTO - NOTNLM OT - Bleeding Control OT - Coagulation OT - Haemorrhage OT - Haemostasis OT - Hot Water Irrigation OT - Postextraction Complications EDAT- 2016/02/14 06:00 MHDA- 2017/10/04 06:00 CRDT- 2016/02/14 06:00 PHST- 2015/03/19 00:00 [received] PHST- 2016/01/16 00:00 [accepted] PHST- 2016/02/14 06:00 [entrez] PHST- 2016/02/14 06:00 [pubmed] PHST- 2017/10/04 06:00 [medline] AID - S0266-4356(16)00022-X [pii] AID - 10.1016/j.bjoms.2016.01.020 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 2016 Apr;54(3):266-9. doi: 10.1016/j.bjoms.2016.01.020. Epub 2016 Feb 10. PMID- 22779380 OWN - NLM STAT- MEDLINE DCOM- 20120814 LR - 20161125 IS - 0265-539X (Print) IS - 0265-539X (Linking) VI - 29 IP - 2 DP - 2012 Jun TI - Clinical evaluation of three caries removal approaches in primary teeth: a randomised controlled trial. PG - 173-8 AB - OBJECTIVE: To evaluate the clinical performance and radiographic outcome of glass ionomer cement (GIC) restoration in primary molars using three caries removal techniques. BASIC RESEARCH DESIGN: Randomised clinical controlled trial. CLINICAL SETTING: Two standard dental clinics in 2 hospitals near Bangkok. PARTICIPANTS: A total of 276 children, aged 6-11, having dentinal caries on the occlusal and/or proximal surface extending at least one-third of dentine without signs and/or symptoms of irreversible pulpitis. INTERVENTION: Children were randomly allocated into 3 study groups with different caries removal techniques: Group 1, partial soft caries removal at enamel-dentine junction (EDJ) by spoon excavation; Group 2, complete soft caries removal by spoon excavation; and Group 3, conventional caries removal by steel burs. All cavity preparations were restored with GIC (Fuji IX, GC Corp., Japan). MAIN OUTCOME MEASURES: Clinical and radiographic evaluations were carried out at 6 and 12 months after restoration. RESULTS: After 12 months, 89, 89, and 88 restorations in Groups 1, 2 and 3 were evaluated. The cumulative survival rates of GIC restorations in Groups 1, 2 and 3 were 83%, 83%, and 89% while the cumulative survival rates of pulp were 99%, 100% and 98% respectively. There were no statistically significant differences in the survival of GIC restorations or pulp in the three groups (p > 0.05). CONCLUSION: The clinical and radiographic evaluations after 12 months indicated that partial soft caries removal at EDJ followed by GIC restoration was comparable to that of ART and conventional approaches. FAU - Phonghanyudh, A AU - Phonghanyudh A AD - Faculty of Dentistry, Thammasat University, Pathum-thani, Thailand. dtaph@mahidol.ac.th FAU - Phantumvanit, P AU - Phantumvanit P FAU - Songpaisan, Y AU - Songpaisan Y FAU - Petersen, P E AU - Petersen PE LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Community Dent Health JT - Community dental health JID - 8411261 RN - 0 (Glass Ionomer Cements) RN - 0 (fuji IX) SB - D SB - IM MH - Child MH - DMF Index MH - Dental Atraumatic Restorative Treatment/instrumentation/methods/standards MH - Dental Caries/diagnostic imaging/*therapy MH - Dental Cavity Preparation/instrumentation/*methods MH - Dental Enamel/diagnostic imaging/pathology MH - Dental Pulp/diagnostic imaging MH - Dental Restoration Failure MH - Dentin/diagnostic imaging/pathology MH - Female MH - Follow-Up Studies MH - Glass Ionomer Cements/chemistry MH - Humans MH - Male MH - Matrix Bands MH - Molar/diagnostic imaging/pathology MH - Pulpitis/diagnostic imaging MH - Radiography MH - Survival Analysis MH - Tooth, Deciduous/diagnostic imaging/pathology MH - Treatment Outcome EDAT- 2012/07/12 06:00 MHDA- 2012/08/15 06:00 CRDT- 2012/07/12 06:00 PHST- 2012/07/12 06:00 [entrez] PHST- 2012/07/12 06:00 [pubmed] PHST- 2012/08/15 06:00 [medline] PST - ppublish SO - Community Dent Health. 2012 Jun;29(2):173-8. PMID- 17664919 OWN - NLM STAT- MEDLINE DCOM- 20070821 LR - 20091211 IS - 1698-6946 (Electronic) IS - 1698-4447 (Linking) VI - 12 IP - 4 DP - 2007 Aug 1 TI - Comparison of two needle models in terms of bevel deformation during truncal block of the inferior alveolar nerve. PG - E317-22 AB - OBJECTIVES: To evaluate the differences in terms of bevel deformation between two types of needle of the same length and external caliber, but with different internal diameters, during truncal block of the inferior alveolar nerve. STUDY DESIGN: Four operators performed truncal block of the inferior alveolar nerve and infiltrating anesthesia of the buccal nerve for the extraction of a lower third molar in 266 patients. The truncal block was carried out using a standard 27G x 35 mm needle with an internal caliber of 0.215 mm, or a 27G x 35 mm XL Monoprotect needle with an internal caliber of 0.265 mm. The infiltrating anesthesia was made with a Monoprotect or XL Monoprotect needle, both with a caliber of 30G and a length of 25 mm, but with different internal calibers (0.215 and 0.265 mm, respectively). The type of needle used, the anesthetic technique and the number of bone contacts was established during the procedure, the operator working side, the side of the tooth to be removed, the operator in charge of the intervention and the presence of bevel deformation after the anesthetic technique were collected for each patient. RESULTS: A statistically significant association was observed between bevel deformation and the operator performing the truncal block, while a statistically significant association (p use <0.05) was recorded between bevel deformation and the operator performing the infiltrating technique, the internal caliber of the needle and the number of bone contacts. CONCLUSIONS: There are no differences between the Monoprotect needles and the XL Monoprotect needles in terms of bevel deformation. Any such deformation can be attributable to physical -mechanical aspects such as the force with which the operator inserts the needle in the tissues- an aspect that in turn conditions the intensity of needle impact upon bone. FAU - Almendros Marqués, Nieves Almendros AU - Almendros Marqués NA AD - School of Dentistry of the University of Barcelona, Barcelona, Spain. FAU - Delgado Molina, Esther AU - Delgado Molina E FAU - Tamarit Borrás, Meritxell AU - Tamarit Borrás M FAU - Berini Aytés, Leonardo AU - Berini Aytés L FAU - Gay Escoda, Cosme AU - Gay Escoda C LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20070801 PL - Spain TA - Med Oral Patol Oral Cir Bucal JT - Medicina oral, patologia oral y cirugia bucal JID - 101231694 SB - D SB - IM MH - Equipment Design MH - Humans MH - *Mandibular Nerve MH - Mechanics MH - *Needles MH - Nerve Block/*instrumentation EDAT- 2007/08/01 09:00 MHDA- 2007/08/22 09:00 CRDT- 2007/08/01 09:00 PHST- 2007/08/01 09:00 [pubmed] PHST- 2007/08/22 09:00 [medline] PHST- 2007/08/01 09:00 [entrez] AID - 10489679 [pii] PST - epublish SO - Med Oral Patol Oral Cir Bucal. 2007 Aug 1;12(4):E317-22. PMID- 17249431 OWN - NLM STAT- MEDLINE DCOM- 20070223 LR - 20161124 IS - 0164-1263 (Print) IS - 0164-1263 (Linking) VI - 28 IP - 6 DP - 2006 Nov-Dec TI - Impact of a biological barrier in pulpectomies of primary molars. PG - 506-10 AB - PURPOSE: The purpose of this in vitro study was to determine whether placement of a resorbable collagen barrier at the apical one third of the root canal could prevent extrusion of pulpectomy filling material. METHODS: Twenty-five extracted primary mandibular second molars, with at least two thirds of root length remaining, were used. The apical third of each root was covered with utility wax, and teeth were embedded in acrylic. Carious tooth structure was removed, crowns were reduced to a flat surface, and canals were accessed and preflared. Working lengths were established by reducing file lengths 2 mm short of the anatomic apex. Cleaning and shaping was performed using hand and rotary files, and canals were irrigated with sodium hypochlorite and dried with paper points. CollaCote was randomly packed into 1 of 2 prepared canals, and obturation was performed with Vitapex. Postoperative radiographs were independently evaluated for the presence of overfilling, and data were statistically analyzed using chi-square analysis. RESULTS: Overfilling was observed in 16% (4/25) of the CollaCote treated canals and in 42% (10/24) of canals when no barriers were used (P = .047). CONCLUSION: The application of CollaCote at the apical one third of the canals did not completely prevent, but did significantly decrease, the risk for overfilling in primary molars. FAU - Johnson, Marlin S AU - Johnson MS AD - Department of Pediatric Dentistry, University of Florida, Gainesville, USA. FAU - Britto, Leandro R AU - Britto LR FAU - Guelmann, Marcio AU - Guelmann M LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Pediatr Dent JT - Pediatric dentistry JID - 7909102 RN - 0 (CollaCote) RN - 0 (Drug Combinations) RN - 0 (Membranes, Artificial) RN - 0 (Root Canal Filling Materials) RN - 0 (Silicones) RN - 0 (calcium hydroxide, iodoform, silicone oil drug combination) RN - 9007-34-5 (Collagen) RN - PF5DZW74VN (Calcium Hydroxide) SB - D SB - IM MH - Absorbable Implants MH - Calcium Hydroxide/therapeutic use MH - Collagen/chemistry MH - Dental Pulp Cavity/diagnostic imaging/pathology MH - Drug Combinations MH - Extravasation of Diagnostic and Therapeutic Materials/prevention & control MH - Humans MH - *Membranes, Artificial MH - Molar/diagnostic imaging/*surgery MH - Pulpectomy/*instrumentation MH - Radiography MH - Root Canal Filling Materials/therapeutic use MH - Root Canal Obturation/methods MH - Root Canal Preparation/instrumentation/methods MH - Silicones/therapeutic use MH - Tooth, Deciduous/diagnostic imaging/*surgery EDAT- 2007/01/26 09:00 MHDA- 2007/02/24 09:00 CRDT- 2007/01/26 09:00 PHST- 2007/01/26 09:00 [pubmed] PHST- 2007/02/24 09:00 [medline] PHST- 2007/01/26 09:00 [entrez] PST - ppublish SO - Pediatr Dent. 2006 Nov-Dec;28(6):506-10. PMID- 1919404 OWN - NLM STAT- MEDLINE DCOM- 19911031 LR - 20131121 IS - 0099-2399 (Print) IS - 0099-2399 (Linking) VI - 17 IP - 2 DP - 1991 Feb TI - Histological evaluation of ultrasonic debridement comparing sodium hypochlorite and water. PG - 66-71 AB - Twenty extracted human mandibular first and second molars with mesial canal curvatures of 18 to 35 degrees were randomly divided into two groups. Following routine endodontic access and canal length determination one of the mesial root canals was ultrasonically instrumented, using tap water in the first group or 2.6% sodium hypochlorite irrigation in the other. In both groups the other mesial canal was used as a control. The mesial roots were decalcified, serially sectioned, and stained with hematoxylin and eosin. Wall planing and soft tissue debridement were blindly evaluated using the light microscope. Mean canal wall planing and soft tissue debridement scores were compared by multiple t tests. Sodium hypochlorite, in conjunction with ultrasonic instrumentation, was more effective than tap water in wall planing when the entire root length was considered. Sodium hypochlorite, in conjunction with ultrasonic instrumentation, was more effective than tap water in soft tissue debridement in the middle third of the canal. Both irrigants were ineffective in conjunction with ultrasonic instrumentation in removing soft tissue from the main canal, the isthmus between canals, the canal fins, and the multiple branches or deltas often encountered in the apical one-third of the canal. FAU - Walker, T L AU - Walker TL AD - Endodontics Department, Naval Dental Clinic, Norfolk, VA. FAU - del Rio, C E AU - del Rio CE LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Endod JT - Journal of endodontics JID - 7511484 RN - 0 (Root Canal Irrigants) RN - 059QF0KO0R (Water) RN - DY38VHM5OD (Sodium Hypochlorite) SB - D MH - Humans MH - Molar MH - *Root Canal Irrigants MH - Root Canal Therapy/*instrumentation/methods MH - Sodium Hypochlorite MH - Ultrasonic Therapy MH - Water EDAT- 1991/02/01 00:00 MHDA- 1991/02/01 00:01 CRDT- 1991/02/01 00:00 PHST- 1991/02/01 00:00 [pubmed] PHST- 1991/02/01 00:01 [medline] PHST- 1991/02/01 00:00 [entrez] AID - S0099-2399(06)81610-9 [pii] AID - 10.1016/S0099-2399(06)81610-9 [doi] PST - ppublish SO - J Endod. 1991 Feb;17(2):66-71. doi: 10.1016/S0099-2399(06)81610-9. PMID- 15133565 OWN - NLM STAT- MEDLINE DCOM- 20041019 LR - 20061115 IS - 1006-7248 (Print) IS - 1006-7248 (Linking) VI - 13 IP - 2 DP - 2004 Apr TI - [Comparison of the effects of three analgesic therapies on odontalgia caused by pulpitis in molars]. PG - 147-9 AB - PURPOSE: To compare the effects of analgesic therapies on odontalgia caused by pulpitis in molars by three different methods. METHODS: 173 molars were diagnosed as irreversible pulpitis, and randomized block designed in three groups. Under block or local anesthesia: 46 cases of the first group, leaving teeth on open drainage, after 1 day, sealing devitalized material (arsenic), arranged next appointment 2 weeks later. 52 molars of the second group, enlarging exposure site, drainage several minutes only, sealed devitalized material, re-examined 2 weeks later. 75 cases of the third group, removing roof of pulp chamber, undergoing pulpectomy directly, re-examined 1 week later. Adopting VAS(vital analogue scale) to analyze the pulp receptivity of three different methods and to evaluate the analgesic effects by complete analgesia, effective analgesia, and no response. The data was analysed using chi-square test. RESULTS: The rate of complete analgesia was 50.0%, 63.46% and 76.0%, respectively. There was a significant difference in complete analgesia among the three methods. The analgesic effect of the third group (pulpectomy) was significantly higher than that of the first group (P<0.01).Pulpectomy group had impossibility of adverse effects caused by using devitalizing material (arsenic). CONCLUSIONS: It is worthy to adopt pulpectomy extensively to relieve the pain of molars caused by pulpitis clinically. The course of treatment of the third group was significantly shorter than other groups, and the simultaneous symptoms occurred rarely. FAU - Wang, Xiao-ping AU - Wang XP AD - Department of Emergency, School of Stomatology, Peking University, Beijing 100081, China. jamesluofeng@yahoo.com FAU - Wang, Zhong-gui AU - Wang ZG FAU - Wang, Xiao-ting AU - Wang XT FAU - Ye, Rong AU - Ye R LA - chi PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial PL - China TA - Shanghai Kou Qiang Yi Xue JT - Shanghai kou qiang yi xue = Shanghai journal of stomatology JID - 101090220 SB - D SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Molar MH - *Pulpectomy MH - Pulpitis/*physiopathology MH - Toothache/*therapy EDAT- 2004/05/11 05:00 MHDA- 2004/10/20 09:00 CRDT- 2004/05/11 05:00 PHST- 2004/05/11 05:00 [pubmed] PHST- 2004/10/20 09:00 [medline] PHST- 2004/05/11 05:00 [entrez] AID - 1512 [pii] PST - ppublish SO - Shanghai Kou Qiang Yi Xue. 2004 Apr;13(2):147-9. PMID- 9461937 OWN - NLM STAT- MEDLINE DCOM- 19980310 LR - 20161124 IS - 0011-8516 (Print) IS - 0011-8516 (Linking) VI - 51 IP - 11 DP - 1996 Nov TI - An observer-blind randomised parallel group study comparing the efficacy and tolerability of tenoxicam and piroxicam in the treatment of post-operative pain after oral surgery. PG - 707-11 AB - Tenoxicam and piroxicam were compared for analgesic efficacy in 58 patients undergoing removal of bilateral impacted third molar teeth, under general anaesthesia. Pain intensity was assessed over a 7 day period by the patient using verbal and visual analogue scales. The patients received one hour pre-operatively dormicum 7.5 mg orally and either tenoxicam 40 mg or piroxicam 40 mg rectally. This was followed by tenoxicam 20 mg daily in effervescent form, or piroxicam 20 mg daily in despersible tablet form for 7 days. Surgical and anaesthetic techniques were standardized for all patients. Therapeutic gain was assessed by comparing hourly pain levels 4 hours post-operatively and then twice daily for 7 days. Trismus was evaluated pre-operatively, at one hour, 24 hours and 7 days post-operatively. Analysis of the results showed a statistical significant difference between the treatment groups only 4 hours post-operatively, patients in the tenoxicam group experiencing less pain than those in the piroxicam group (p = < 0.05). FAU - Roelofse, J A AU - Roelofse JA AD - Division of Anaesthesia, Faculty of Dentistry, Tygerberg. FAU - Swart, L C AU - Swart LC FAU - Stander, I A AU - Stander IA LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - South Africa TA - J Dent Assoc S Afr JT - The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika JID - 7505600 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Suppositories) RN - 0 (Tablets) RN - 13T4O6VMAM (Piroxicam) RN - Z1R9N0A399 (tenoxicam) SB - D MH - Adolescent MH - Adult MH - Anesthesia, Dental MH - Anesthesia, General MH - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/adverse effects MH - Humans MH - Pain Measurement/statistics & numerical data MH - Pain, Postoperative/*drug therapy MH - Piroxicam/*administration & dosage/adverse effects/*analogs & derivatives MH - Single-Blind Method MH - Suppositories MH - Tablets MH - *Tooth Extraction EDAT- 1996/11/01 00:00 MHDA- 1998/02/14 00:01 CRDT- 1996/11/01 00:00 PHST- 1996/11/01 00:00 [pubmed] PHST- 1998/02/14 00:01 [medline] PHST- 1996/11/01 00:00 [entrez] PST - ppublish SO - J Dent Assoc S Afr. 1996 Nov;51(11):707-11. PMID- 6936524 OWN - NLM STAT- MEDLINE DCOM- 19810424 LR - 20201209 IS - 0022-3255 (Print) IS - 0022-3255 (Linking) VI - 39 IP - 2 DP - 1981 Feb TI - An evaluation of the analgesic efficacy of three opioid-analgesic combinations in postoperative oral surgery pain. PG - 108-12 AB - The analgesic efficacy of a hydrocodone-acetaminophen combination, a codeine-acetaminophen combination, a codeine-APC (aspirin, phenacetin, and caffeine) combination, and a placebo was evaluated in outpatients who had moderate or severe pain after the surgical removal of impacted third molars. Each of the active medications had a significant effect on essentially all measures of total and peak analgesia; they did not differ significantly on any measure of analgesia. Adverse effects were transitory and, in general, appear to have been related to the centrally acting component of each combination analgesic. FAU - Forbes, J A AU - Forbes JA FAU - Bowser, M W AU - Bowser MW FAU - Calderazzo, J P AU - Calderazzo JP FAU - Foor, V M AU - Foor VM LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Oral Surg JT - Journal of oral surgery (American Dental Association : 1965) JID - 8302454 RN - 0 (Analgesics) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - 6YKS4Y3WQ7 (Hydrocodone) RN - ER0CTH01H9 (Phenacetin) RN - R16CO5Y76E (Aspirin) RN - UX6OWY2V7J (Codeine) SB - AIM SB - D SB - IM MH - Acetaminophen/therapeutic use MH - Adolescent MH - Adult MH - Analgesics/adverse effects/*therapeutic use MH - Aspirin/therapeutic use MH - Codeine/therapeutic use MH - Drug Combinations MH - Female MH - Humans MH - Hydrocodone/therapeutic use MH - Male MH - Molar/surgery MH - Pain, Postoperative/*drug therapy MH - Phenacetin/therapeutic use EDAT- 1981/02/01 00:00 MHDA- 1981/02/01 00:01 CRDT- 1981/02/01 00:00 PHST- 1981/02/01 00:00 [pubmed] PHST- 1981/02/01 00:01 [medline] PHST- 1981/02/01 00:00 [entrez] PST - ppublish SO - J Oral Surg. 1981 Feb;39(2):108-12. PMID- 8951927 OWN - NLM STAT- MEDLINE DCOM- 19970311 LR - 20190818 IS - 0304-3959 (Print) IS - 0304-3959 (Linking) VI - 67 IP - 2-3 DP - 1996 Oct TI - Pain control after dental surgery: a double-blind, randomised trial of lornoxicam versus morphine. PG - 335-43 AB - Lornoxicam is a new non-steroidal anti-inflammatory drug of the oxicam class. This randomised, double-blind, placebo controlled trial compared the analgesic efficacy and tolerability of intramuscular (IM) injections of lornoxicam (4, 8, 16 and 20 mg) with morphine (10 and 20 mg) and placebo in 252 patients with mainly moderate to severe pain following surgical removal of an impacted mandibular third molar. Patients treated with lornoxicam or morphine experienced a significantly greater cumulative pain relief over the 4-h post-injection period (TOTPAR0-4) than placebo recipients. This effect appeared to be dose-dependent, with patients in the lornoxicam 4 mg or morphine 10 mg groups recording significantly lower TOTPAR0-4 scores than patients in the higher dosage groups of these drugs. No significant difference was detected between the morphine 20 mg group and the lornoxicam 8, 16 and 20 mg groups. Lornoxicam was well tolerated at all doses and was associated with a significantly lower incidence of adverse events than morphine 10 or 20 mg. Thus, the analgesic efficacy of IM lornoxicam at doses > or = 4 mg is superior to placebo, and doses > or = 8 mg are at least as effective as IM morphine 20 mg. Furthermore, lornoxicam possesses a more favourable tolerability profile than morphine and thus represents an attractive alternative for the treatment of moderate to severe acute pain. FAU - Nørholt, S E AU - Nørholt SE AD - Department of Oral Surgery, Aarhus University, Denmark. FAU - Sindet-Pedersen, S AU - Sindet-Pedersen S FAU - Larsen, U AU - Larsen U FAU - Bang, U AU - Bang U FAU - Ingerslev, J AU - Ingerslev J FAU - Nielsen, O AU - Nielsen O FAU - Hansen, H J AU - Hansen HJ FAU - Ersbøll, A K AU - Ersbøll AK LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (Analgesics, Opioid) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) RN - 76I7G6D29C (Morphine) RN - ER09126G7A (lornoxicam) SB - IM MH - Adolescent MH - Adult MH - Analgesics, Opioid/adverse effects/*therapeutic use MH - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Morphine/adverse effects/*therapeutic use MH - *Palliative Care MH - Piroxicam/adverse effects/*analogs & derivatives/therapeutic use MH - *Postoperative Care MH - *Tooth Extraction MH - Treatment Outcome EDAT- 1996/10/01 00:00 MHDA- 1996/10/01 00:01 CRDT- 1996/10/01 00:00 PHST- 1996/10/01 00:00 [pubmed] PHST- 1996/10/01 00:01 [medline] PHST- 1996/10/01 00:00 [entrez] AID - 10.1016/0304-3959(96)03126-0 [doi] PST - ppublish SO - Pain. 1996 Oct;67(2-3):335-43. doi: 10.1016/0304-3959(96)03126-0. PMID- 8530994 OWN - NLM STAT- MEDLINE DCOM- 19960201 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 54 IP - 1 DP - 1996 Jan TI - Preliminary study of low-level laser for treatment of long-standing sensory aberrations in the inferior alveolar nerve. PG - 2-7; discussion 7-8 AB - PURPOSE: The incidence of inferior alveolar nerve (IAN) damage during removal of third molar teeth has been reported to be as high as 5.5% and up to 100% during sagittal split osteotomy. Sensory aberrations in the IAN persisting for longer than 6 months leave some degree of permanent disability. The purpose of this double-blind, clinical trial was to examine the effects of low-level laser (LLL) treatment using a GaAIAs laser (820 nm, Rønvig, Denmark) on touch and temperature sensory perception after a long-standing postsurgical IAN injury. PATIENTS AND METHODS: Thirteen patients were divided into two groups, one of which received real LLL (4 x 6 J per treatment along the distribution of the IAN to a total of 20 treatments) and the other placebo LLL. The degree of mechanoreceptor injury as assessed by Semmes Weinstein Monofilaments (North Coast Medical, San Jose, CA) were comparable in the two groups before treatment. The degree of thermal sensitivity disability as assessed using a Thermotester (Somedic AB, Stockholm, Sweden) to examine the indifferent temperature threshold was also comparable between the two groups before LLL. RESULTS: Subsequent to LLL, the real laser-treated group showed a significant improvement in mechanoreceptor sensory testing (P = .01) compared with the placebo group, as manifested by a decrease in load threshold (g) necessary to elicit a response from the most damaged area. In addition, the real LLL group reported a subjective improvement in sensory function. There was no significant improvement in thermal sensitivity post-LLL for either the real or placebo laser-treated groups. CONCLUSION: It was concluded that LLL can improve mechanoreceptor perception in long-standing sensory aberrations in the IAN. FAU - Khullar, S M AU - Khullar SM AD - Department of Oral Surgery and Oral Medicine, University of Oslo, Blindern, Norway. FAU - Brodin, P AU - Brodin P FAU - Barkvoll, P AU - Barkvoll P FAU - Haanaes, H R AU - Haanaes HR LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - AIM SB - D SB - IM SB - S MH - Adolescent MH - Adult MH - Double-Blind Method MH - Humans MH - *Laser Therapy MH - Mandibular Nerve/physiopathology MH - Mechanoreceptors/physiology/radiation effects MH - Middle Aged MH - Nerve Regeneration MH - Osteotomy/adverse effects MH - Pain Measurement MH - Paresthesia/etiology/*radiotherapy MH - Sensory Thresholds/radiation effects MH - Thermosensing MH - Tooth Extraction/adverse effects MH - Treatment Outcome MH - *Trigeminal Nerve Injuries EDAT- 1996/01/01 00:00 MHDA- 1996/01/01 00:01 CRDT- 1996/01/01 00:00 PHST- 1996/01/01 00:00 [pubmed] PHST- 1996/01/01 00:01 [medline] PHST- 1996/01/01 00:00 [entrez] AID - S0278-2391(96)90290-6 [pii] AID - 10.1016/s0278-2391(96)90290-6 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1996 Jan;54(1):2-7; discussion 7-8. doi: 10.1016/s0278-2391(96)90290-6. PMID- 815188 OWN - NLM STAT- MEDLINE DCOM- 19760602 LR - 20201209 IS - 0300-9785 (Print) IS - 0300-9785 (Linking) VI - 4 IP - 6 DP - 1975 Dec TI - Paracetamol/codeine in relieving pain following removal of impacted mandibular third molars. PG - 258-66 AB - A double-blind clinical study of analgesic drugs was conducted involving 47 healthy adults requiring removal of 90 bony impacted mandibular third molars. The analgesic effect of paracetamol plus codeine (P + C) 350 + 20 mg was compared to that of acetylsalicylic acid (ASA) 500 mg and placebo. A standardized surgical procedure under local anesthesia was used. Insufficient analgesic effect was noted in 16% of the ASA group and in 69% of the placebo group but in none in the P+C group. On the first postoperative day, patients given P+C suffered less pain compared with those given ASA (P less than 0.01). No relationship could be demonstrated between the type of impaction and intensity of pain. Trismus, however, was found to be associated with difficulty of extirpation. Drowsiness and an increased sleeping tendency were the main side effects found in the P+C group. The incidence of secondary hemorrhage was high in the ASA group, compared with the P+C group a significance of 0.01 less than P less than 0.05 was found on various postoperative days. Registration of swelling revealed less postoperative edema in the P+C group than in the ASA group (0.01less thanPless than0.05). The main conclusion from this study is that the analgesic effect of P+C orally administered after a specific oral surgical procedure is superior to ASA and placebo. P+C also appears to have a more marked antiphologistic effect than ASA. FAU - Sveen, K AU - Sveen K FAU - Gilhuus-Moe, O AU - Gilhuus-Moe O LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - Denmark TA - Int J Oral Surg JT - International journal of oral surgery JID - 0334641 RN - 0 (Placebos) RN - 362O9ITL9D (Acetaminophen) RN - R16CO5Y76E (Aspirin) RN - UX6OWY2V7J (Codeine) SB - D SB - IM MH - Acetaminophen/*therapeutic use MH - Adolescent MH - Adult MH - Aspirin/therapeutic use MH - Codeine/*therapeutic use MH - Drug Therapy, Combination MH - Edema MH - Female MH - Humans MH - Male MH - Molar MH - Pain/*drug therapy MH - Placebos MH - *Tooth Extraction MH - Tooth, Impacted/*surgery MH - Wound Healing EDAT- 1975/12/01 00:00 MHDA- 1975/12/01 00:01 CRDT- 1975/12/01 00:00 PHST- 1975/12/01 00:00 [pubmed] PHST- 1975/12/01 00:01 [medline] PHST- 1975/12/01 00:00 [entrez] AID - 10.1016/s0300-9785(75)80043-3 [doi] PST - ppublish SO - Int J Oral Surg. 1975 Dec;4(6):258-66. doi: 10.1016/s0300-9785(75)80043-3. PMID- 33089877 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20201222 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 24 IP - 12 DP - 2020 Dec TI - Comparison of three anesthetic techniques for the removal of posterior mandibular teeth with 2% lidocaine: a systematic review. PG - 4143-4152 LID - 10.1007/s00784-020-03580-2 [doi] AB - OBJECTIVES: The present systematic review aimed to evaluate whether the IANB (conventional inferior alveolar nerve block) technique is superior to the VA (Vazirani-Akinosi) or GG (Gow-Gates) techniques for anesthesia in the removal of posterior mandibular teeth. MATERIALS AND METHODS: This systematic review was structured according to the PICO strategy, adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist, and was recorded on the international prospective register of systematic reviews (PROSPERO-CRD42020153130). Studies were included based on the eligibility criteria and data from the included studies were collected by one author, while another reviewed the compilation. RESULTS: Eight studies were included, all of which were randomized controlled trials. Three studies tested the techniques by exclusively performing lower third molar removal; the others covered other posterior lower teeth. All studies used the same local anesthetic and the same vasoconstrictor: lidocaine 2% with epinephrine/adrenaline. A total of 1056 patients were evaluated. CONCLUSIONS: Some differences were observed between the techniques. Because of the heterogeneity between studies, clinical trials with more specific methodologies, such as comparisons of GG and VA with IANB for mandibular tooth removal, and the same clinical homogeneity will be worthwhile. CLINICAL RELEVANCE: A systematic review of which anesthetic technique is most effective for mandibular teeth removal may positively impact the population's life. There are no systematic reviews which approach this theme in a well-structured perspective. FAU - de França, Arthur José Barbosa AU - de França AJB AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Oswaldo Cruz Hospital, University of Pernambuco, Recife, PE, Brazil. FAU - Costa, Rayanna Thayse Florêncio AU - Costa RTF AD - Department of Prosthodontics, School of Dentistry, University of Pernambuco, Recife, PE, Brazil. FAU - Monteiro, João Luiz Gomes Carneiro AU - Monteiro JLGC AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Oswaldo Cruz Hospital, University of Pernambuco, Recife, PE, Brazil. FAU - Rocha, Nelson Studart AU - Rocha NS AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Oswaldo Cruz Hospital, University of Pernambuco, Recife, PE, Brazil. FAU - do Egito Vasconcelos, Belmiro Cavalcanti AU - do Egito Vasconcelos BC AD - Department of Oral and Maxillofacial Surgery, School of Dentistry, Oswaldo Cruz Hospital, University of Pernambuco, Arnóbio Marques Street, 310 - Santo Amaro, Recife, PE, 50.100-130, Brazil. belmiro.vasconcelos@upe.br. FAU - de Moraes, Sandra Lúcia Dantas AU - de Moraes SLD AD - Department of Prosthodontics, School of Dentistry, University of Pernambuco, Recife, PE, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20201022 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Anesthetics, Local) RN - 98PI200987 (Lidocaine) SB - D MH - *Anesthesia, Dental MH - Anesthetics, Local MH - Humans MH - Lidocaine MH - Mandibular Nerve MH - *Nerve Block MH - Prospective Studies OTO - NOTNLM OT - Anesthetics OT - Gow-Gates OT - IANB OT - Oral surgery OT - Systematic review OT - Vazirani-Akinosi EDAT- 2020/10/23 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/10/22 08:48 PHST- 2020/06/23 00:00 [received] PHST- 2020/09/09 00:00 [accepted] PHST- 2020/10/23 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/10/22 08:48 [entrez] AID - 10.1007/s00784-020-03580-2 [pii] AID - 10.1007/s00784-020-03580-2 [doi] PST - ppublish SO - Clin Oral Investig. 2020 Dec;24(12):4143-4152. doi: 10.1007/s00784-020-03580-2. Epub 2020 Oct 22. PMID- 21891918 OWN - NLM STAT- MEDLINE DCOM- 20120126 LR - 20151119 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 22 IP - 2 DP - 2011 Mar-Apr TI - Rotary Mtwo system versus manual K-file instruments: efficacy in preparing primary and permanent molar root canals. PG - 363 LID - 10.4103/0970-9290.84283 [doi] AB - AIM: To compare the cleaning ability and preparation time of rotary instruments (Mtwo) and conventional manual instruments (K-file) in preparing primary and permanent molar root canals. MATERIALS AND METHODS: Access cavities were prepared in 70 primary and 70 permanent teeth and India ink was injected into 120 canals of selected molars. The teeth were randomly divided into two main subgroups (n=20) and three control groups (n=10). In each of these main subgroups, either the manual instrument (K-file) or the rotary system (Mtwo) was used to prepare root canals. After cleaning the canals and clearing the teeth, dye removal was evaluated with the help of a stereomicroscope. In addition, the time needed for root canal preparation was recorded by a chronometer. STATISTICAL ANALYSIS: Statistical analyses were done using the Kruskal-Wallis, Mann-Whitney and t tests. RESULTS: With regard to the cleaning ability of root canals, there were no significant differences between the K-file and Mtwo rotary system in primary and permanent teeth in the apical, middle or coronal third of the canals. Moreover, there were no significant differences between primary and permanent teeth prepared with K-files and rotary instruments. In all the groups, shorter times were recorded with the rotary technique. The working time was shorter in primary than in permanent teeth. CONCLUSION: The Mtwo rotary system showed acceptable cleaning ability in both primary and permanent teeth, and achieved results similar to those of K-files in less time. FAU - Azar, Mohammad-Reza AU - Azar MR AD - Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. azarm@sums.ac.ir FAU - Mokhtare, Maziar AU - Mokhtare M LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 RN - 0 (Coloring Agents) RN - 0 (Dental Alloys) RN - 0 (chinese ink) RN - 12035-60-8 (titanium nickelide) RN - 7440-44-0 (Carbon) RN - 7OV03QG267 (Nickel) RN - D1JT611TNE (Titanium) SB - D MH - Carbon MH - Coloring Agents MH - Dental Alloys/chemistry MH - Dental Pulp Cavity/*pathology MH - Equipment Design MH - Equipment Failure MH - Humans MH - Materials Testing MH - Molar/*pathology MH - Nickel/chemistry MH - Root Canal Preparation/*instrumentation/methods MH - Rotation MH - Time Factors MH - Titanium/chemistry MH - Tooth Apex/pathology MH - Tooth, Deciduous/*pathology MH - Torque EDAT- 2011/09/06 06:00 MHDA- 2012/01/27 06:00 CRDT- 2011/09/06 06:00 PHST- 2011/09/06 06:00 [entrez] PHST- 2011/09/06 06:00 [pubmed] PHST- 2012/01/27 06:00 [medline] AID - IndianJDentRes_2011_22_2_363_84283 [pii] AID - 10.4103/0970-9290.84283 [doi] PST - ppublish SO - Indian J Dent Res. 2011 Mar-Apr;22(2):363. doi: 10.4103/0970-9290.84283. PMID- 18795524 OWN - NLM STAT- MEDLINE DCOM- 20081210 LR - 20151119 IS - 0894-8275 (Print) IS - 0894-8275 (Linking) VI - 21 IP - 4 DP - 2008 Aug TI - Histological evaluation of mineral trioxide aggregate and calcium hydroxide in direct pulp capping of human immature permanent teeth. PG - 262-6 AB - PURPOSE: To evaluate histological findings in human immature permanent premolars scheduled for extraction for orthodontic reasons, in which mechanical pulp exposures were capped with white ProRoot Mineral Trioxide Aggregate (WMTA) or calcium hydroxide (CH). METHODS: Forty-eight human immature premolars in 23 patients (age 10-18 years) were randomly treated with WMTA or CH. After rubber dam isolation Cl I cavities were prepared and the pulps exposed. After hemostasis the pulps were capped with either material. The preparations were restored using an acid etch, bonding agent, flowable composite and composite resin technique. The teeth were extracted after 47 to 609 days and processed for routine histological examination, stained with hematoxylin and eosin and Brown and Brenn for recognition of bacteria. Statistical analyses of inflammation, bridge formation and bacterial leakage were performed using a Chi-square test and ANOVA. RESULTS: Forty-four of 48 teeth were suitable for microscopic evaluation, 30 with WMTA, 14 with CH. Of the WMTA group, 29 teeth were vital, 28 had formed a bridge, and one specimen had failed. Twelve of 14 teeth with CH were vital, while three teeth failed to form a bridge. No statistically significant differences between WMTA and CH were found, except for superficial and deep inflammatory cell response (P < or = 0.05). Pulp capping of intentionally exposed human immature premolars performed slightly better when using MTA. FAU - Sawicki, Leszek AU - Sawicki L AD - Department of Pediatric Dentistry, Medical University of Gdansk, ul E. Orzeszkowej 18, 80-208 Gdańsk, Poland. sawicki@endodoncja.pl FAU - Pameijer, Cornelis H AU - Pameijer CH FAU - Emerich, Katarzyna AU - Emerich K FAU - Adamowicz-Klepalska, Barbara AU - Adamowicz-Klepalska B LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Dent JT - American journal of dentistry JID - 8806701 RN - 0 (Aluminum Compounds) RN - 0 (Calcium Compounds) RN - 0 (Coloring Agents) RN - 0 (Composite Resins) RN - 0 (Dentin-Bonding Agents) RN - 0 (Drug Combinations) RN - 0 (Fluorescent Dyes) RN - 0 (Oxides) RN - 0 (Root Canal Filling Materials) RN - 0 (Silicates) RN - 0 (flowable hybrid composite) RN - 0 (mineral trioxide aggregate) RN - PF5DZW74VN (Calcium Hydroxide) SB - D MH - Acid Etching, Dental MH - Adolescent MH - Aluminum Compounds/*therapeutic use MH - Bicuspid MH - Calcium Compounds/*therapeutic use MH - Calcium Hydroxide/*therapeutic use MH - Child MH - Coloring Agents MH - Composite Resins/chemistry MH - Dental Leakage/microbiology MH - Dental Pulp/*drug effects/microbiology/pathology MH - *Dental Pulp Capping MH - Dental Pulp Exposure/therapy MH - Dental Restoration, Permanent/methods MH - Dentin, Secondary/pathology MH - Dentin-Bonding Agents/chemistry MH - Drug Combinations MH - Female MH - Fluorescent Dyes MH - Follow-Up Studies MH - Humans MH - Male MH - Oxides/*therapeutic use MH - Pulpitis/pathology MH - Root Canal Filling Materials/*therapeutic use MH - Silicates/*therapeutic use MH - Tooth, Nonvital/pathology EDAT- 2008/09/18 09:00 MHDA- 2008/12/17 09:00 CRDT- 2008/09/18 09:00 PHST- 2008/09/18 09:00 [pubmed] PHST- 2008/12/17 09:00 [medline] PHST- 2008/09/18 09:00 [entrez] PST - ppublish SO - Am J Dent. 2008 Aug;21(4):262-6. PMID- 33772121 OWN - NLM STAT- MEDLINE DCOM- 20210405 LR - 20210405 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 22 IP - 1 DP - 2021 Jan TI - Are different pulp treatment techniques and associated medicaments effective for the treatment of extensive decay in primary teeth? PG - 12-13 LID - 10.1038/s41432-021-0162-6 [doi] AB - Data sources Cochrane Oral Health's Trials Register and Central Register of Controlled Trials, Medline Ovid, Embase Ovid, Web of Science, Open Grey, US National Institutes of Health Ongoing Trials Register and World Health Organisation International Clinical Trials Registry Platform. There were no restrictions on language or publication dates.Study selection Two reviewers selected randomised clinical trials (RCTs) comparing different pulp interventions in extensively decayed primary teeth, which combined a pulp treatment technique and a medicament.Data extraction and synthesis Data were extracted independently by two reviewers recording year of publication, country of origin, inclusion/exclusion criteria, description of interventions, sample size, mean age, duration of follow-up and outcome data. Risk of bias was assessed by two reviewers. Meta-analysis was performed on RCTs comparing different medicaments for the same pulp technique or different pulp treatment techniques with each other.Results Eighty-seven RCTs were included in qualitative synthesis, yielding 59 studies for meta-analysis. The 87 RCTs involved 7,140 randomised teeth with 17 split-mouth RCTs and 70 parallel arm design. In total, 125 different comparisons were examined using clinical and radiological failure rates; 75 compared different pulpotomy agents or techniques, 25 compared different pulpectomy agents, four compared pulpotomy and pulpectomy, and 21 compared different agents for direct pulp capping. Where possible, data were compared for 6, 12 and 24 months. For pulpotomy, mineral trioxide aggregate (MTA) appears least likely to fail over those time periods. For pulpectomy, results were inconclusive comparing failure rates between various agents; however, two RCTs found a lower failure rate for zinc oxide-eugenol (ZOE) compared with Vitapex. For direct pulp capping, there was a low number of studies undertaking the same comparisons; calcium silicates (eg MTA and Biodentine) hold future promise.Conclusions Overall, evidence quality ranged from moderate to very low. For pulpotomy, MTA may be the best pulpotomy medicament in primary molars. Formocresol is effective but generally accepted as toxic. Biodentine, enamel matrix derivatives, laser application or Ankaferd Blood Stopper (a plant-based haemostatic agent used to control gastrointestinal bleeds) appear to be second choices. If all of these are unavailable, an application of sodium hypochlorite may be the safest option. For pulpectomy, evidence was inconclusive; however, ZOE paste may be more effective than Vitapex, but no further conclusions could be made. For direct pulp capping, the evidence was of low to very low quality. The best alternative may be a tricalcium silicate, especially MTA. Future RCTs may change these findings. FAU - Waterhouse, Paula AU - Waterhouse P AD - Clinical Senior Lecturer in Child Dental Health and Honorary Consultant in Paediatric Dentistry, The School of Dental Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Department of Paediatric Dentistry, Newcastle Dental Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Zinc Oxide-Eugenol Cement) SB - D SB - IM CON - Cochrane Database Syst Rev. 2018 May 31;5:CD003220. PMID: 29852056 MH - *Dental Caries MH - Humans MH - Pulpectomy MH - Pulpotomy MH - Tooth, Deciduous MH - Zinc Oxide-Eugenol Cement EDAT- 2021/03/28 06:00 MHDA- 2021/04/07 06:00 CRDT- 2021/03/27 06:17 PHST- 2021/03/27 06:17 [entrez] PHST- 2021/03/28 06:00 [pubmed] PHST- 2021/04/07 06:00 [medline] AID - 10.1038/s41432-021-0162-6 [pii] AID - 10.1038/s41432-021-0162-6 [doi] PST - ppublish SO - Evid Based Dent. 2021 Jan;22(1):12-13. doi: 10.1038/s41432-021-0162-6. PMID- 16808575 OWN - NLM STAT- MEDLINE DCOM- 20060912 LR - 20161124 IS - 0003-3219 (Print) IS - 0003-3219 (Linking) VI - 76 IP - 4 DP - 2006 Jul TI - Forsus Nitinol Flat Spring and Jasper Jumper corrections of Class II division 1 malocclusions. PG - 666-72 AB - OBJECTIVE: To compare the effects of Forsus Nitinol Flat Spring (FNFS) and Jasper Jumper (JJ) in the correction of Class II division I malocclusions. MATERIALS AND METHODS: Our research was conducted on 48 adolescents, who had a normal or horizontal growth pattern and retrognathic mandible. The patients were divided into three equal groups randomly. First group was treated with FNFS, and the second group was treated with JJ appliances, whereas the third group was the control group. Lateral cephalograms and study models were obtained after the leveling phase and at time of the removal of the appliances. RESULTS: Cephalometric analysis revealed that both the appliances stimulated mandibular growth, increased the anterior face height because of the lower face, and elongated the posterior face height because of the growth of temporomandibular joint. Maxillary central incisors were extruded, retruded, and distally tipped. Contrarily, intrusion, protrusion, and labial tipping were observed in the mandibular central incisors. Distal movement and intrusion of the maxillary first molars and mesial movement and extrusion of the mandibular first molars were the other dental alterations. Overjet and overbite were decreased, and a Class I molar relationship and improvement in the profile were attained in both treatment groups. Cast model analysis showed expansion in the maxillary and mandibular dental arches. CONCLUSIONS: Both the appliances were effective in the treatment of Class II malocclusion and revealed nearly same alterations in the skeletal, dental, and soft tissue parameters. FAU - Karacay, Seniz AU - Karacay S AD - Department of Orthodontics, Dental Science Center, Gulhane Military Medical Academy, Ankara, Turkey. senkaracay@yahoo.com FAU - Akin, Erol AU - Akin E FAU - Olmez, Huseyin AU - Olmez H FAU - Gurton, A Umit AU - Gurton AU FAU - Sagdic, Deniz AU - Sagdic D LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Angle Orthod JT - The Angle orthodontist JID - 0370550 RN - 0 (Alloys) RN - 0 (Dental Alloys) RN - 12035-60-8 (titanium nickelide) RN - 2EWL73IJ7F (nitinol) RN - 7OV03QG267 (Nickel) RN - D1JT611TNE (Titanium) SB - D SB - IM MH - *Activator Appliances MH - Adolescent MH - *Alloys MH - Cephalometry MH - *Dental Alloys MH - Dental Arch/pathology MH - Dental Models MH - Female MH - Humans MH - Incisor/pathology MH - Male MH - Malocclusion, Angle Class II/*therapy MH - Mandible/growth & development MH - Maxilla/pathology MH - Molar/pathology MH - Nickel MH - *Orthodontic Appliance Design MH - *Orthodontic Appliances MH - Prospective Studies MH - Retrognathia/therapy MH - Temporomandibular Joint/growth & development MH - Titanium MH - Tooth Movement Techniques MH - Vertical Dimension EDAT- 2006/07/01 09:00 MHDA- 2006/09/13 09:00 CRDT- 2006/07/01 09:00 PHST- 2006/07/01 09:00 [pubmed] PHST- 2006/09/13 09:00 [medline] PHST- 2006/07/01 09:00 [entrez] AID - 10.1043/0003-3219(2006)076[0666:FNFSAJ]2.0.CO;2 [doi] PST - ppublish SO - Angle Orthod. 2006 Jul;76(4):666-72. doi: 10.1043/0003-3219(2006)076[0666:FNFSAJ]2.0.CO;2. PMID- 22008303 OWN - NLM STAT- MEDLINE DCOM- 20120224 LR - 20161125 IS - 1601-6343 (Electronic) IS - 1601-6335 (Linking) VI - 14 IP - 4 DP - 2011 Nov TI - Effect of cyclosporine-A on orthodontic tooth movement in rats. PG - 234-42 LID - 10.1111/j.1601-6343.2011.01528.x [doi] AB - OBJECTIVE: The objective of this study is to examine the effect of cyclosporine-A (CsA) on the rate of orthodontic tooth movement in rats. SETTING AND SAMPLE POPULATION: This is a randomized controlled trial with a split-mouth design in Sprague-Dawley rats. MATERIAL AND METHODS: Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate-resistant acid phosphatase (TRAP)-5b level detection and for histology, respectively. RESULTS: Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter-radicular dental alveolus of CSA-fed rats was osteopenic. Significantly increased TRAP-5b serum level was noted in the CsA group when compared with the control group. CONCLUSIONS: We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors. CI - © 2011 John Wiley & Sons A/S. FAU - Chen, R Y AU - Chen RY AD - Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan. FAU - Fu, M M AU - Fu MM FAU - Chih, Y K AU - Chih YK FAU - Gau, C H AU - Gau CH FAU - Chiang, C Y AU - Chiang CY FAU - Nieh, S AU - Nieh S FAU - Hsieh, Y D AU - Hsieh YD FAU - Fu, E AU - Fu E LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Orthod Craniofac Res JT - Orthodontics & craniofacial research JID - 101144387 RN - 0 (Biomarkers) RN - 0 (Immunosuppressive Agents) RN - 0 (Isoenzymes) RN - 83HN0GTJ6D (Cyclosporine) RN - EC 3.1.3.2 (Acid Phosphatase) RN - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase) SB - D SB - IM MH - Acid Phosphatase/analysis MH - Alveolar Process/drug effects/pathology MH - Animals MH - Biomarkers/analysis MH - Bone Diseases, Metabolic/pathology MH - Bone Remodeling/drug effects MH - Cyclosporine/*pharmacology MH - Immunosuppressive Agents/*pharmacology MH - Isoenzymes/analysis MH - Male MH - Maxilla/drug effects/pathology MH - Molar/drug effects/pathology MH - Orthodontic Wires MH - Osteoclasts/drug effects/pathology MH - Random Allocation MH - Rats MH - Rats, Sprague-Dawley MH - Stress, Mechanical MH - Tartrate-Resistant Acid Phosphatase MH - Time Factors MH - Tooth Movement Techniques/instrumentation/*methods EDAT- 2011/10/20 06:00 MHDA- 2012/03/01 06:00 CRDT- 2011/10/20 06:00 PHST- 2011/10/20 06:00 [entrez] PHST- 2011/10/20 06:00 [pubmed] PHST- 2012/03/01 06:00 [medline] AID - 10.1111/j.1601-6343.2011.01528.x [doi] PST - ppublish SO - Orthod Craniofac Res. 2011 Nov;14(4):234-42. doi: 10.1111/j.1601-6343.2011.01528.x. PMID- 33772125 OWN - NLM STAT- MEDLINE DCOM- 20210405 LR - 20210405 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 22 IP - 1 DP - 2021 Jan TI - What is the best caries removal strategy for primary molars? PG - 20-21 LID - 10.1038/s41432-021-0150-x [doi] AB - Aim This systematic review and meta-analysis of randomised controlled trials (RCTs) aimed to compare the efficacy of different caries removal techniques: complete caries removal (CCR), selective caries removal (SCR) and stepwise caries removal (SWR) for deep carious lesions in vital primary teeth.Data sources The design of this review followed the PRISMA guidance ( http://www.prisma-statement.org/ ). Relevant studies were identified using electronic databases (PubMed [Medline], Cochrane Library, EMBASE) and finally reference lists were screened. The US National Institutes of Health Trials Register (NIHTR; http://clinicaltrials.gov ) and World Health Organisation International Clinical Trials Registry Platform (WHO ICTRP; http://apps.who.int/trialsearch ) were used to help assess publication bias, as it was not possible to test funnel plot asymmetry. Duplicates were located and eliminated using EndNote X7 programme.Study selection To be included, studies had to be published RCTs comparing SCR or SWR with CCR as caries removal strategies for deep carious lesions in vital primary teeth. The outcomes were pulp exposure, pulpo-periodontal complications (clinical and radiological failures) and/or restorative failures. RCTs applying these caries removal techniques were excluded if one of the other trial arms did not involve caries removal (that is, Hall Technique, therapeutic sealing of cavity lesions). Initially, 1,374 potentially eligible articles were identified, out of which 15 (English or French language only) were selected for full-text screening, which included ten relevant references corresponding to eight studies.Data extraction and synthesis Two authors independently extracted data using a piloted data extraction sheet, with a third reviewer resolving any disagreements. The authors performed conventional intention-to-treat and per-protocol meta-analyses, and calculated odds ratios (ORs) as effect estimates in the random-effects model, using Revman5.Results The eight included RCTs were conducted between 1977 and 2018. They include 669 patients and 824 teeth, with follow-up ranging from four weeks to 24 months. Collective results showed reduced risk of pulp exposure after SCR (OR: 0.10, 95% CI [0.04, 0.25]) or SWR (OR: 0.20, 95% CI [0.09, 0.44]), compared with CCR. There was a higher risk of composite restorative failure (OR: 2.61, 95% CI [1.05, 6.49]) using United States Public Health Service (USPHS) criteria, after SCR was compared with CCR only in intention-to-treat analysis. However, when comparing the risk of clinical or radiographic failure of pulpo-periodontal complications, no difference was found between SCR, CCR or SWR.Conclusion The conclusions of the paper are that there is a significant decrease in pulp exposure risk with SCR and SWR in comparison with CCR. However, there is a need for further studies with less risk of bias powered to report on the long-term outcomes of pulpo-periodontal health and restoration longevity. FAU - Hamouda, Mariam AU - Hamouda M AD - Postgraduate student, Unit of Oral Health, Dentistry and Society, School of Clinical Dentistry, University of Sheffield, Clarement Crescent, Sheffield, S10 2TA, UK. FAU - Deery, Chris AU - Deery C AD - Dean, Professor/Honorary Consultant in Paediatric Dentistry, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 SB - D SB - IM CON - Int J Paediatr Dent. 2020 Jul;30(4):392-404. PMID: 31943437 MH - Data Management MH - *Dental Caries/therapy MH - *Dental Caries Susceptibility MH - Humans MH - Molar MH - Tooth, Deciduous MH - United States EDAT- 2021/03/28 06:00 MHDA- 2021/04/07 06:00 CRDT- 2021/03/27 06:17 PHST- 2021/03/27 06:17 [entrez] PHST- 2021/03/28 06:00 [pubmed] PHST- 2021/04/07 06:00 [medline] AID - 10.1038/s41432-021-0150-x [pii] AID - 10.1038/s41432-021-0150-x [doi] PST - ppublish SO - Evid Based Dent. 2021 Jan;22(1):20-21. doi: 10.1038/s41432-021-0150-x. PMID- 32873466 OWN - NLM STAT- MEDLINE DCOM- 20201006 LR - 20201006 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 48 IP - 10 DP - 2020 Oct TI - Effectiveness of knotless suture as a wound closure agent for impacted third molar - A split mouth randomized controlled clinical trial. PG - 1004-1008 LID - S1010-5182(20)30179-7 [pii] LID - 10.1016/j.jcms.2020.07.014 [doi] AB - AIM AND OBJECTIVE: This study was aimed to compare the effectiveness of 3-0 knotless barbed suture (polydioxanone) with 4-0 polyglactin 910 (vicryl) in achieving wound closure after impacted mandibular third molar surgery. MATERIALS AND METHODS: Patients with bilateral mandibular third molar impaction of similar difficulty index enrolled in the split mouth study. Wound closure was done using 3-0 knotless suture (30 × 30 cm) for the study group and 4-0 polyglactin 910 (vicryl) for the control group following extraction. Samples were allocated on the basis of simple randomization. The clinical outcome parameters that were measured were (1) time taken to achieve wound closure and hemostasis (2) postoperative mouth opening (3) swelling and (4) Pain. Data analysis involved descriptive statistics and paired t-tests (p < 0.05). IBM SPSS software (v.20.0) was used. RESULT: A total of 25 patients participated in the study (14 males and 11 females) with the mean age of 25.6 years. The mean time taken for wound approximation was 2.45 min and 4.1480 min (p-0.026) for the study and control groups respectively. The difference in mouth opening (p-0.015), VAS score(p-0.24), and swelling (p-0.041) were statistically significant on the first post-operative day in the study group than the control group indicating reduction in pain (p < 0.0001), swelling (p-0.033) and improvement in mouth opening (p < 0.0001) on seventh post-operative day in the study group compared to the control group. CONCLUSION: Knotless suture is an effective alternative to conventional sutures for intra oral wound closure as it reduces suturing time, facilitates effective wound closure and minimises knot related complications. CI - Copyright © 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Ramkumar Ceyar, K A AU - Ramkumar Ceyar KA AD - Department of Oral & Maxillofacial Surgery, SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu 600089, India. Electronic address: drrkceyar@gmail.com. FAU - Thulasidoss, Guru Prasad AU - Thulasidoss GP AD - Department of Oral & Maxillofacial Surgery, SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu 600089, India. Electronic address: drguru84@gmail.com. FAU - Raja Sethupathy Cheeman, S AU - Raja Sethupathy Cheeman S AD - Department of Oral & Maxillofacial Surgery, SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu 600089, India. Electronic address: zeusians.noss@gmail.com. FAU - Sagadevan, Sembiyan AU - Sagadevan S AD - Department of Oral & Maxillofacial Surgery, SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu 600089, India. Electronic address: sembi2494@gmail.com. FAU - Panneerselvam, Elavenil AU - Panneerselvam E AD - Department of Oral & Maxillofacial Surgery, SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu 600089, India. Electronic address: elavenilomfs@gmail.com. FAU - Krishna Kumar Raja, V B AU - Krishna Kumar Raja VB AD - Department of Oral & Maxillofacial Surgery, SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu 600089, India. Electronic address: kksukanya@gmail.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200801 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 SB - D SB - IM MH - Adult MH - Edema/etiology/prevention & control MH - Female MH - Humans MH - Male MH - Molar, Third/*surgery MH - Mouth MH - Suture Techniques MH - Sutures MH - Tooth, Impacted/*surgery OTO - NOTNLM OT - Impacted third molar OT - Knotless suture OT - Minor oral surgery OT - Wound closure EDAT- 2020/09/03 06:00 MHDA- 2020/10/07 06:00 CRDT- 2020/09/03 06:00 PHST- 2020/01/24 00:00 [received] PHST- 2020/06/25 00:00 [revised] PHST- 2020/07/25 00:00 [accepted] PHST- 2020/09/03 06:00 [pubmed] PHST- 2020/10/07 06:00 [medline] PHST- 2020/09/03 06:00 [entrez] AID - S1010-5182(20)30179-7 [pii] AID - 10.1016/j.jcms.2020.07.014 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2020 Oct;48(10):1004-1008. doi: 10.1016/j.jcms.2020.07.014. Epub 2020 Aug 1. PMID- 24071673 OWN - NLM STAT- MEDLINE DCOM- 20160620 LR - 20181202 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 14 IP - 3 DP - 2013 Sep TI - Partial caries removal may have advantages but limited evidence on restoration survival. PG - 74-5 LID - 10.1038/sj.ebd.6400948 [doi] AB - DATA SOURCES: Cochrane Oral Health Group's Trials Register, CENTRAL, Medline via OVID, EMBASE via OVID; no restrictions on language or date of publication. STUDY SELECTION: Parallel group and split mouth randomised and quasi-randomised controlled trials comparing stepwise, partial and no dentinal caries removal with complete caries removal in unrestored primary and permanent teeth were included in this review. DATA EXTRACTION AND SYNTHESIS: Title and abstract screening was by two reviewers, with disagreements resolved by a third. Full texts of eligible studies were assessed by the team until consensus, and data extraction was by three reviewers independently and in triplicate. Two reviewers assessed risk of bias. Trial authors were contacted where possible . RESULTS: Eight trials (all assessed as high risk of bias) with 934 participants and 1372 teeth were included in this updated review (Previously complete or ultraconservative removal of decayed tissue in unfilled teeth, Ricketts, 2006) with four new trials being included. There were a number of different comparisons in the trials (stepwise or partial or no dentinal caries removal compared to complete caries removal) with one study including more than one of these comparisons. Four studies investigated primary teeth, three permanent teeth and one included both.For stepwise caries removal, (four studies), there was a 56% reduction in incidence of pulp exposure (RR 0.44, 95% CI 0.33 to 0.60, P < 0.00001) compared to complete caries removal. The mean pulp exposure incidence was 34.7% in the complete caries removal group and 15.4% in the stepwise groups. There was no difference in signs and symptoms of pulp disease (RR 0.78, 95% CI 0.39 to 1.58, P = 0.50).In the two partial caries removal studies, the incidence of pulp exposure reduction was 77% for the partial caries removal group (RR 0.23, 95% CI 0.08 to 0.69, P = 0.009) with a mean pulp exposure incidence of 21.9% in the complete caries removal groups and 5% in the partial caries removal groups. There was insufficient evidence to determine whether or not there was a difference in signs and symptoms of pulp disease (RR 0.27, 95% CI 0.05 to 1.60, P = 0.15), or restoration failure (one study showing no difference and another study showing no failures in either group).There were two very different studies which looked at no dentinal caries removal compared to complete caries removal. There was some evidence of no difference between these techniques for the outcome of signs and symptoms of pulp disease and reduced risk of restoration failure, favouring no dentinal caries removal, from one study. There were no instances of pulp disease or restoration failure in either group from the second study. Meta-analysis of these two studies was not carried out because of the substantial clinical differences between the studies. CONCLUSIONS: For management of dentinal caries, both stepwise and partial excavation showed clinical advantage over complete caries removal by reducing the incidence of pulp exposure in symptomless, vital, carious primary as well as permanent teeth. The review found no difference in signs or symptoms of pulpal disease between stepwise excavation and complete caries removal.There was insufficient evidence to determine whether there was a difference in signs and symptoms of pulp disease or a difference in the risk of restoration failure with partial caries removal.For the two no dentinal caries removal studies, the one investigating permanent teeth found no difference in restoration failure and the one investigating primary teeth found a statistically significant difference in restoration failure favouring the intervention.Due to the short term follow-up, low reporting of patient centred outcomes and high risk of bias, further high quality, long-term clinical trials are still required to assess the most effective intervention. FAU - Manton, David AU - Manton D AD - Department of Child Dental Health, Melbourne Dental School, The University of Melbourne, Melbourne, Australia. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Cariostatic Agents) RN - 0 (Pit and Fissure Sealants) SB - D SB - IM CON - Cochrane Database Syst Rev. 2013;(3):CD003808. PMID: 23543523 MH - Cariostatic Agents/*therapeutic use MH - Dental Caries/*therapy MH - *Dental Pulp MH - *Dentin MH - Humans MH - Pit and Fissure Sealants/*therapeutic use EDAT- 2013/09/28 06:00 MHDA- 2016/06/21 06:00 CRDT- 2013/09/28 06:00 PHST- 2013/09/28 06:00 [entrez] PHST- 2013/09/28 06:00 [pubmed] PHST- 2016/06/21 06:00 [medline] AID - 6400948 [pii] AID - 10.1038/sj.ebd.6400948 [doi] PST - ppublish SO - Evid Based Dent. 2013 Sep;14(3):74-5. doi: 10.1038/sj.ebd.6400948. PMID- 1544291 OWN - NLM STAT- MEDLINE DCOM- 19920413 LR - 20190509 IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 51 IP - 3 DP - 1992 Mar TI - Analgesic efficacy of bromfenac, ibuprofen, and aspirin in postoperative oral surgery pain. PG - 343-52 AB - We recently demonstrated that 25 mg of bromfenac, a new nonsteroidal anti-inflammatory analgesic, is at least as effective as 400 mg of ibuprofen in relieving postoperative oral surgery pain. Our objective in this study was to determine whether higher doses were significantly more effective. Two hundred eighty (280) outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, a single oral dose of 10, 25, 50, or 100 mg bromfenac; 650 mg aspirin; 400 mg ibuprofen; or placebo. Subjects rated their pain and its relief for 8 hours. All active treatments were significantly superior to placebo, and bromfenac and ibuprofen were significantly superior to aspirin. The slope of the dose-response curve of bromfenac was significant. The 100 mg bromfenac dose was significantly more effective than the 400 mg ibuprofen dose and had a significantly longer duration of analgesic action. FAU - Forbes, J A AU - Forbes JA AD - Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore. FAU - Beaver, W T AU - Beaver WT FAU - Jones, K F AU - Jones KF FAU - Edquist, I A AU - Edquist IA FAU - Gongloff, C M AU - Gongloff CM FAU - Smith, W K AU - Smith WK FAU - Smith, F G AU - Smith FG FAU - Schwartz, M K AU - Schwartz MK LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Benzophenones) RN - 0 (Bromobenzenes) RN - 864P0921DW (bromfenac) RN - R16CO5Y76E (Aspirin) RN - WK2XYI10QM (Ibuprofen) SB - AIM SB - IM MH - Aspirin/*administration & dosage MH - Benzophenones/*administration & dosage/adverse effects MH - Bromobenzenes/*administration & dosage/adverse effects MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Humans MH - Ibuprofen/*administration & dosage MH - Molar/surgery MH - Pain, Postoperative/*prevention & control MH - Tooth, Impacted/*surgery EDAT- 1992/03/01 00:00 MHDA- 1992/03/01 00:01 CRDT- 1992/03/01 00:00 PHST- 1992/03/01 00:00 [pubmed] PHST- 1992/03/01 00:01 [medline] PHST- 1992/03/01 00:00 [entrez] AID - 10.1038/clpt.1992.31 [doi] PST - ppublish SO - Clin Pharmacol Ther. 1992 Mar;51(3):343-52. doi: 10.1038/clpt.1992.31. PMID- 1449617 OWN - NLM STAT- MEDLINE DCOM- 19930106 LR - 20131121 IS - 0895-8831 (Print) IS - 0895-8831 (Linking) VI - 3 IP - 3 DP - 1992 TI - Two-year longitudinal study of a peroxide-fluoride rinse on decalcification in adolescent orthodontic patients. PG - 83-7 AB - The purpose of the present study was to determine if once daily use of a 1.5% H2O2 rinse with 0.05% NaF was more effective in preventing decalcification in adolescent orthodontic patients than comparable use of a 0.05% NaF rinse without H2O2, or in patients using no rinse at all. Ninety-five subjects were selected consecutively from adolescents scheduled to receive fixed orthodontic treatment on both dental arches. Three groups were formed that were matched in percentages for age and sex. The first group (control group, n = 35) used a 1100 ppm F toothpaste only. The second group (NaF rinse group, n = 30) used both the same toothpaste and a once daily 0.05% NaF rinse. The third group (H2O2-NaF rinse group, n = 30) used the toothpaste and a once daily rinse containing both 0.05% NaF and 1.5% H2O2. Decalcification was assessed single-blind on the facial surfaces of all erupted teeth at baseline (before appliances were placed), and 3 months after fixed appliances were removed. The difference between baseline and post-treatment decalcification levels determined the incidence of decalcification during orthodontic treatment. Since the first molars were found to have the highest decalcification scores, separate analyses of variance were carried out for the whole mouth and first molar assessments. A p value of less than 0.05 was considered statistically significant. The results showed no significant differences between any of the groups before orthodontic treatment.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Boyd, R L AU - Boyd RL AD - Department of Growth and Development, University of California, San Francisco. LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - J Clin Dent JT - The Journal of clinical dentistry JID - 8904411 RN - 0 (Mouthwashes) RN - 0 (Toothpastes) RN - 8ZYQ1474W7 (Sodium Fluoride) RN - BBX060AN9V (Hydrogen Peroxide) SB - D MH - Adolescent MH - Analysis of Variance MH - Child MH - Female MH - Humans MH - Hydrogen Peroxide/*therapeutic use MH - Longitudinal Studies MH - Male MH - Mouthwashes/*therapeutic use MH - Orthodontic Brackets/adverse effects MH - Sodium Fluoride/*therapeutic use MH - Tooth Demineralization/etiology/*prevention & control MH - Toothpastes/therapeutic use EDAT- 1992/01/01 00:00 MHDA- 1992/01/01 00:01 CRDT- 1992/01/01 00:00 PHST- 1992/01/01 00:00 [pubmed] PHST- 1992/01/01 00:01 [medline] PHST- 1992/01/01 00:00 [entrez] PST - ppublish SO - J Clin Dent. 1992;3(3):83-7. PMID- 25747157 OWN - NLM STAT- MEDLINE DCOM- 20160114 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 3 DP - 2015 TI - Can acupuncture treatment be double-blinded? An evaluation of double-blind acupuncture treatment of postoperative pain. PG - e0119612 LID - 10.1371/journal.pone.0119612 [doi] LID - e0119612 AB - Blinding protects against bias but the success of blinding is seldom assessed and reported in clinical trials including studies of acupuncture where blinding represents a major challenge. Recently, needles with the potential for double-blinding were developed, so we tested if acupuncture can be double-blinded in a randomized study of sixty-seven patients with acute pain ≥ 3 (0-10 scale following third molar removal) who received active acupuncture with a penetrating needle or placebo acupuncture with a non-penetrating needle. To test if acupuncture was administered double-blind, patients and acupuncturists were asked about perceived treatment allocation at the end of the study. To test if there were clues which led to identification of the treatment, deep dull pain associated with needle application and rotation (termed "de qi" in East Asian medicine), and patients' pain levels were assessed. Perceived treatment allocation depended on actual group allocation (p < 0.015) for both patients and acupuncturists, indicating that the needles were not successful in double-blinding. Up to 68% of patients and 83% of acupuncturists correctly identified the treatment, but for patients the distribution was not far from 50/50. Also, there was a significant interaction between actual or perceived treatment and the experience of de qi (p = 0.027), suggesting that the experience of de qi and possible non-verbal clues contributed to correct identification of the treatment. Yet, of the patients who perceived the treatment as active or placebo, 50% and 23%, respectively, reported de qi. Patients' acute pain levels did not influence the perceived treatment. In conclusion, acupuncture treatment was not fully double-blinded which is similar to observations in pharmacological studies. Still, the non-penetrating needle is the only needle that allows some degree of practitioner blinding. The study raises questions about alternatives to double-blind randomized clinical trials in the assessment of acupuncture treatment. FAU - Vase, Lene AU - Vase L AD - Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark; Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark. FAU - Baram, Sara AU - Baram S AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus University, Aarhus, Denmark; Section of Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus University, Aarhus, Denmark. FAU - Takakura, Nobuari AU - Takakura N AD - Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan. FAU - Takayama, Miho AU - Takayama M AD - Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan. FAU - Yajima, Hiroyoshi AU - Yajima H AD - Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan. FAU - Kawase, Akiko AU - Kawase A AD - Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan. FAU - Schuster, Lars AU - Schuster L AD - The Acupuncture Academy, Copenhagen and Aarhus, Denmark. FAU - Kaptchuk, Ted J AU - Kaptchuk TJ AD - Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America. FAU - Schou, Søren AU - Schou S AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus University, Aarhus, Denmark. FAU - Jensen, Troels Staehelin AU - Jensen TS AD - Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark. FAU - Zachariae, Robert AU - Zachariae R AD - Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. FAU - Svensson, Peter AU - Svensson P AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus University, Aarhus, Denmark. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20150306 TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Acupuncture Analgesia/*instrumentation/*methods MH - Adult MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Pain Management/*instrumentation/*methods MH - Pain, Postoperative/*therapy MH - Tooth Extraction/adverse effects PMC - PMC4352029 COIS- Competing Interests: Nobuari Takakura (NT) and the Educational Foundation of Hanada Gakuen possess a U.S. patent 6575992B1 (patent title: Safe needle, placebo needle, and needle set for double blind), a Canadian patent CA 2339223 (patent title: Safe needle, placebo needle, and needle set for double blind), a Korean patent 0478177 (patent title: Safe needle, placebo needle, and needle set for double blind), a Taiwan patent 150135 (patent title: Safe needle, placebo needle, and needle set for double blind), a Chinese patent ZL00800894.9 (patent title: Safe needle, placebo needle, and needle set for double blind), a Hong Kong patent HK1036928 (patent title: Safe needle, placebo needle, and needle set for double blind), and a Japanese patent 4061397 (patent title: Placebo needle, and needle set for double-blinding). The safe needle is a penetrating needle and the placebo needle is a non-penetrating needle as illustrated and described in this paper. The needle set is a pair of penetrating needles and non-penetrating needles for use in double-blind acupuncture studies. NT is a salaried employee of the Educational Foundation of Hanada Gakuen and has received research funding from the Educational Foundation of Hanada Gakuen. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. EDAT- 2015/03/10 06:00 MHDA- 2016/01/15 06:00 CRDT- 2015/03/10 06:00 PHST- 2014/01/28 00:00 [received] PHST- 2015/02/01 00:00 [accepted] PHST- 2015/03/10 06:00 [entrez] PHST- 2015/03/10 06:00 [pubmed] PHST- 2016/01/15 06:00 [medline] AID - PONE-D-14-04247 [pii] AID - 10.1371/journal.pone.0119612 [doi] PST - epublish SO - PLoS One. 2015 Mar 6;10(3):e0119612. doi: 10.1371/journal.pone.0119612. eCollection 2015. PMID- 17943420 OWN - NLM STAT- MEDLINE DCOM- 20091127 LR - 20181113 IS - 1573-8744 (Electronic) IS - 1567-567X (Linking) VI - 35 IP - 1 DP - 2008 Feb TI - A mechanistic model for the sex-specific response to nalbuphine and naloxone in postoperative pain. PG - 69-83 AB - We develop a mechanistic model for post-operative pain and apply it to describe the pharmacodynamic effects of the kappa-opioids nalbuphine and naloxone administered either alone or in combination in patients after surgical removal of one or more madibular third molar teeth. Data were obtained from 6 clinical studies in which a total of 304 patients were intravenously administered single doses of 2.5, 5, 10 or 20 mg of nalbuphine. Some groups also received 0.2 or 0.4 mg of naloxone. A total of 3,040 Visual analog scale (VAS) pain ratings were recorded at 20 min intervals for 3 h after drug administration. We used a two-site indirect action model to describe early and late pain and to incorporate the effect of nalbuphine and naloxone on pain over time. A mixed effects statistical model was used to account for inter- and intra-individual variability. Our model estimated the population average baseline pain score in men to be lower than that in women (68 vs. 76 mm on the 100 mm VAS scale). The model confirmed a late increase in pain (anti-analgesia) and estimated the lag time for the start of anti-analgesia to be 73 min after study drug administration. The maximum early phase pain score is 81.6 mm while the maximum anti-analgesia is 16.1 mm. The nalbuphine dose required to reduce early pain by 50% (ED(50)) was estimated to be 5.85 mg and the naloxone dose required to reduce late phase pain by 50% was estimated to be 0.5 mg. The model confirmed the results from conventional statistical analyses performed previously on individual studies. FAU - Kshirsagar, Smita AU - Kshirsagar S AD - Department of Medicine, Stanford University Medical Center, Stanford, CA, USA. FAU - Gear, Robert AU - Gear R FAU - Levine, Jon AU - Levine J FAU - Verotta, Davide AU - Verotta D LA - eng GR - AI50587/AI/NIAID NIH HHS/United States GR - GM26696/GM/NIGMS NIH HHS/United States GR - NR03923/NR/NINR NIH HHS/United States GR - R01DE018526-01/DE/NIDCR NIH HHS/United States GR - T32GM07065/GM/NIGMS NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural DEP - 20071018 PL - United States TA - J Pharmacokinet Pharmacodyn JT - Journal of pharmacokinetics and pharmacodynamics JID - 101096520 RN - 36B82AMQ7N (Naloxone) RN - L2T84IQI2K (Nalbuphine) SB - IM MH - Double-Blind Method MH - Female MH - Humans MH - Male MH - Models, Chemical MH - *Models, Statistical MH - Nalbuphine/*therapeutic use MH - Naloxone/*therapeutic use MH - Pain, Postoperative/*physiopathology/*prevention & control MH - *Sex Characteristics EDAT- 2007/10/19 09:00 MHDA- 2009/12/16 06:00 CRDT- 2007/10/19 09:00 PHST- 2006/06/26 00:00 [received] PHST- 2007/09/20 00:00 [accepted] PHST- 2007/10/19 09:00 [pubmed] PHST- 2009/12/16 06:00 [medline] PHST- 2007/10/19 09:00 [entrez] AID - 10.1007/s10928-007-9076-y [doi] PST - ppublish SO - J Pharmacokinet Pharmacodyn. 2008 Feb;35(1):69-83. doi: 10.1007/s10928-007-9076-y. Epub 2007 Oct 18. PMID- 20722756 OWN - NLM STAT- MEDLINE DCOM- 20110324 LR - 20131121 IS - 1365-2591 (Electronic) IS - 0143-2885 (Linking) VI - 43 IP - 11 DP - 2010 Nov TI - Histological evaluation of the effectiveness of increased apical enlargement for cleaning the apical third of curved canals. PG - 988-94 LID - 10.1111/j.1365-2591.2010.01724.x [doi] AB - OBJECTIVE: To evaluate the influence of apical size on cleaning of the apical third of curved canals prepared with rotary instruments. METHODOLOGY: Forty-four mesiobuccal canals of maxillary molars teeth were instrumented to different apical sizes (30, 0.02; 35, 0.02; 40, 0.02; 45, 0.02) using a crown-down technique. After canal preparation, the apical thirds of the roots were submitted to histological processing and examination. The specimens were analysed at 40× magnification and the images were submitted to morphometric analysis with an integration grid to evaluate the percentage of debris and uninstrumented root canal walls. The action of the instruments on the root canal walls was assessed based on the surface regularity, abrupt change on the continuity of root canal walls, and partial or total pre-dentine removal. The results were statistically compared using one-way anova with post hoc Tukey test. Pearson's correlation was performed to identify potential correlations between values. RESULTS: The percentage of uninstrumented root canal dentine was higher when apical enlargement was performed with instruments 30, 0.02 taper (55.64 ± 4.62%) and 35, 0.02 taper (49.03 ± 5.70%) than with instruments 40, 0.02 taper (38.08 ± 10.44%) and 45, 0.02 taper (32.65 ± 8.51%) (P < 0.05). More debris were observed when apical enlargement was performed with instruments 30, 0.02 taper (34.62 ± 9.49%) and 35, 0.02 taper (25.33 ± 7.37%) (P < 0.05). There was a significant correlation between the amount of remaining debris and the perimeter of uninstrumented root canal dentine (r = 0.9130, P < 0.001). CONCLUSION: No apical enlargement size allowed the root canal walls to be prepared completely. Apical third cleanliness could be predicted by instrument diameter. CI - © 2010 International Endodontic Journal. FAU - Fornari, V J AU - Fornari VJ AD - Department of Endodontics, Faculty of Dentistry, University of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil. FAU - Silva-Sousa, Y T C AU - Silva-Sousa YT FAU - Vanni, J R AU - Vanni JR FAU - Pécora, J D AU - Pécora JD FAU - Versiani, M A AU - Versiani MA FAU - Sousa-Neto, M D AU - Sousa-Neto MD LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20100816 PL - England TA - Int Endod J JT - International endodontic journal JID - 8004996 RN - 0 (Dental Alloys) RN - 0 (Root Canal Irrigants) RN - 12035-60-8 (titanium nickelide) RN - 7OV03QG267 (Nickel) RN - D1JT611TNE (Titanium) SB - D MH - Dental Alloys/chemistry MH - Dental High-Speed Equipment MH - Dental Pulp Cavity/*pathology MH - Dentin/pathology MH - Equipment Design MH - Humans MH - Materials Testing MH - Molar/pathology MH - Nickel/chemistry MH - Root Canal Irrigants/therapeutic use MH - Root Canal Preparation/instrumentation/*methods MH - Smear Layer MH - Surface Properties MH - Titanium/chemistry MH - Tooth Apex/*pathology EDAT- 2010/08/21 06:00 MHDA- 2011/03/25 06:00 CRDT- 2010/08/21 06:00 PHST- 2010/08/21 06:00 [entrez] PHST- 2010/08/21 06:00 [pubmed] PHST- 2011/03/25 06:00 [medline] AID - IEJ1724 [pii] AID - 10.1111/j.1365-2591.2010.01724.x [doi] PST - ppublish SO - Int Endod J. 2010 Nov;43(11):988-94. doi: 10.1111/j.1365-2591.2010.01724.x. Epub 2010 Aug 16. PMID- 27897461 OWN - NLM STAT- MEDLINE DCOM- 20190325 LR - 20190325 IS - 1548-1336 (Electronic) IS - 0160-6972 (Linking) VI - 43 IP - 1 DP - 2017 Feb TI - Stability Development of Immediately Loaded Hybrid Self-Tapping Implants Inserted in the Posterior Maxilla: 1-Year Results of a Randomized Controlled Trial. PG - 33-38 LID - 10.1563/aaid-joi-D-16-00143 [doi] AB - The objective of the present study was to elucidate stability development of immediately loaded hybrid self-tapping implants inserted in the posterior maxilla. Forty-eight hybrid self-tapping implants with a chemically modified surface (∅4.1; length: 8 mm) were inserted bilaterally in the maxillary first and second premolar and first molar sites of 8 patients. In each patient, both sides of the maxilla were assigned randomly to either immediate (IL) or early (EL) loading group. Implant stability was evaluated by means of resonance frequency analysis immediately after implant placement and after 1, 2, 3, 4, 5, 6, 12, 26, and 52 weeks. High values of primary stability were found in both groups (71.91 ± 6.52 implant stability quotient [ISQ] in IL group; 73.87 ± 6.5 ISQ in EL group), with significant differences between the groups at the different time points. Initial decrease in stability was observed between the first and fifth weeks in the IL group and between the first and third weeks for the EL group. In the IL group 1 implant was removed after 3 weeks due to lack of stability. Early results of this study showed the ability of hybrid self-tapping dental implants with a chemically modified surface to achieve sufficient primary stability and to maintain high values of secondary implant stability in bone type 3 and 4, even when loaded immediately. Minimal alterations in stability were observed for both investigated groups, but the EL group showed faster recovery after an initial drop in stability. FAU - Todorovic, Vladimir S AU - Todorovic VS AD - 1   Oral Surgery Department, School of Dental Medicine, University of Belgrade, Serbia. AD - 2   Department of Periodontics and Oral Medicine, School of Dentistry, University of Pretoria, South Africa. FAU - Vasovic, Miroslav AU - Vasovic M AD - 3   Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Serbia. FAU - Beetge, Mia-Michaela AU - Beetge MM AD - 2   Department of Periodontics and Oral Medicine, School of Dentistry, University of Pretoria, South Africa. FAU - van Zyl, Andre W AU - van Zyl AW AD - 2   Department of Periodontics and Oral Medicine, School of Dentistry, University of Pretoria, South Africa. FAU - Kokovic, Vladimir AU - Kokovic V AD - 4   Advanced Europe Medical Centre, Dental Department, Sharjah, United Arab Emirates. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20161129 PL - United States TA - J Oral Implantol JT - The Journal of oral implantology JID - 7801086 RN - 0 (Dental Implants) SB - D MH - Bicuspid MH - Dental Implantation, Endosseous MH - *Dental Implants MH - Dental Prosthesis Design MH - Dental Restoration Failure MH - Humans MH - *Maxilla OTO - NOTNLM OT - hybrid self-tapping dental implants OT - immediate loading OT - implant stability OT - posterior maxilla EDAT- 2016/11/30 06:00 MHDA- 2019/03/26 06:00 CRDT- 2016/11/30 06:00 PHST- 2016/11/30 06:00 [pubmed] PHST- 2019/03/26 06:00 [medline] PHST- 2016/11/30 06:00 [entrez] AID - 10.1563/aaid-joi-D-16-00143 [doi] PST - ppublish SO - J Oral Implantol. 2017 Feb;43(1):33-38. doi: 10.1563/aaid-joi-D-16-00143. Epub 2016 Nov 29. PMID- 3183054 OWN - NLM STAT- MEDLINE DCOM- 19881214 LR - 20181113 IS - 0021-9738 (Print) IS - 0021-9738 (Linking) VI - 82 IP - 5 DP - 1988 Nov TI - Potentiation of pentazocine analgesia by low-dose naloxone. PG - 1574-7 AB - The analgesia produced by combinations of low-dose naloxone with pentazocine or morphine was studied in 105 patients with moderately severe postoperative pain after standardized surgery for removal of impacted third molars. Pain intensity was quantified using a visual-analogue scale. To eliminate the release of endogenous opioids produced by the placebo component of open drug administration, all injections were made by a preprogrammed infusion pump. The analgesia produced by pentazocine, an agonist-antagonist opiate-analgesic acting predominantly at the kappa opiate receptor, was potentiated by low-dose naloxone, whereas the analgesia produced by morphine, a mu-agonist, was attenuated by low-dose naloxone. To evaluate whether similar potentiation would be present in an animal model, and specifically, in the absence of diazepam, which patients receive, we performed an analogous experiment in rats in which nociceptive threshold was determined using the Randall-Selitto paw-withdrawal test. The results were completely analogous to the clinical results: pentazocine analgesia was potentiated by low-dose naloxone, whereas morphine analgesia was attenuated by low-dose naloxone. These data demonstrate a novel interaction between opiates, and suggest a rationale for opiate combinations to produce potent analgesia with fewer autonomic side effects and less abuse potential than presently available analgesics. FAU - Levine, J D AU - Levine JD AD - Department of Medicine, School of Medicine and Dentistry, University of California, San Francisco 94143. FAU - Gordon, N C AU - Gordon NC FAU - Taiwo, Y O AU - Taiwo YO FAU - Coderre, T J AU - Coderre TJ LA - eng GR - AM32634/AM/NIADDK NIH HHS/United States GR - DE05369/DE/NIDCR NIH HHS/United States GR - NS21642/NS/NINDS NIH HHS/United States PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. TA - J Clin Invest JT - The Journal of clinical investigation JID - 7802877 RN - 36B82AMQ7N (Naloxone) RN - 76I7G6D29C (Morphine) RN - RP4A60D26L (Pentazocine) SB - AIM SB - IM MH - Analgesia MH - Animals MH - Dose-Response Relationship, Drug MH - Drug Synergism MH - Humans MH - Male MH - Molar/surgery MH - Morphine/therapeutic use MH - Naloxone/*therapeutic use MH - Pentazocine/*therapeutic use MH - Rats MH - Rats, Inbred Strains MH - Surgery, Oral PMC - PMC442725 EDAT- 1988/11/01 00:00 MHDA- 1988/11/01 00:01 CRDT- 1988/11/01 00:00 PHST- 1988/11/01 00:00 [pubmed] PHST- 1988/11/01 00:01 [medline] PHST- 1988/11/01 00:00 [entrez] AID - 10.1172/JCI113768 [doi] PST - ppublish SO - J Clin Invest. 1988 Nov;82(5):1574-7. doi: 10.1172/JCI113768. PMID- 15336468 OWN - NLM STAT- MEDLINE DCOM- 20041108 LR - 20201208 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 26 IP - 7 DP - 2004 Jul TI - Onset of analgesia and analgesic efficacy of tramadol/acetaminophen and codeine/acetaminophen/ibuprofen in acute postoperative pain: a single-center, single-dose, randomized, active-controlled, parallel-group study in a dental surgery pain model. PG - 1037-45 AB - BACKGROUND: The combination of tramadol and acetaminophen has demonstrated good efficacy in various clinical pain models. However, there is a need for comparisons of the onset of analgesia and other measures of analgesic efficacy with this combination and other strong combination analgesics for the management of acute pain. OBJECTIVE: The goal of this study was to compare the time to onset of analgesia and other measures of analgesic efficacy with tramadol/acetaminophen 75/650 mg (Tr/Ac) and codeine/acetaminophen/ibuprofen 20/500/400 mg (Co/Ac/Ib) in the management of acute pain after oral surgery. METHODS: This was a single-center, single-dose, randomized, active-controlled, parallel-group study in healthy subjects who had undergone surgical extraction of > or =1 impacted third molar requiring bone removal. When patients reported at least moderate pain after dental surgery (score > or =5 on a 10-point scale), they were randomized to 1 of 2 treatment groups. The time to onset of analgesia was measured using a 2-stopwatch technique. The time to the onset of perceptible and meaningful pain relief, pain intensity, pain relief, patient's overall assessment, and adverse events were recorded for 6 hours after dosing. RESULTS: One hundred twenty-eight subjects participated in the study, 64 in each treatment group. The 2 groups were similar in terms of baseline pain severity and demographic characteristics (mean age, 23.7 and 23.4 years in the Tr/Ac and Co/Ac/Ib groups, respectively; mean body weight, 58.5 and 60.3 kg). The median times to the onset of perceptible pain relief were a respective 21.0 and 24.4 minutes, and the median times to the onset of meaningful pain relief were 56.4 and 57.3 minutes. Mean total pain relief and the sum of pain intensity difference were also similar in the early period after dosing (0-4 hours). However, between 4 and 6 hours, Co/Ac/Ib was associated with significant differences in both variables compared with Tr/Ac (P < 0.05). Although similar through the 4-hour assessment, mean pain intensity difference was significantly greater with Co/Ac/Ib at 5 to 6 hours. The proportion of patients assessing their assigned treatment as good or better was significantly greater with Co/Ac/Ib compared with Tr/Ac (P < 0.05). The safety profile of Tr/Ac was comparable to that of Co/Ac/Ib. CONCLUSIONS: In this small and selected group of subjects, the onset of analgesia and analgesic efficacy of Tr/Ac was comparable to that of Co/Ac/Ib. Tr/Ac provided rapid and effective analgesia for acute postoperative dental pain in this population. FAU - Jung, Young-Soo AU - Jung YS AD - Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea. FAU - Kim, Dong Kee AU - Kim DK FAU - Kim, Moon-Key AU - Kim MK FAU - Kim, Hyung-Jun AU - Kim HJ FAU - Cha, In-Ho AU - Cha IH FAU - Lee, Eui-Wung AU - Lee EW LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Analgesics, Opioid) RN - 0 (Drug Combinations) RN - 362O9ITL9D (Acetaminophen) RN - 39J1LGJ30J (Tramadol) RN - UX6OWY2V7J (Codeine) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Acetaminophen/administration & dosage/*therapeutic use MH - Adolescent MH - Adult MH - *Analgesia MH - Analgesics, Opioid/administration & dosage/*therapeutic use MH - Codeine/administration & dosage/*therapeutic use MH - Drug Combinations MH - Female MH - Humans MH - Ibuprofen/administration & dosage/*therapeutic use MH - Male MH - Pain, Postoperative/*drug therapy/etiology MH - Time Factors MH - *Tooth Extraction MH - Tramadol/administration & dosage/*therapeutic use EDAT- 2004/09/01 05:00 MHDA- 2004/11/09 09:00 CRDT- 2004/09/01 05:00 PHST- 2004/05/24 00:00 [accepted] PHST- 2004/09/01 05:00 [pubmed] PHST- 2004/11/09 09:00 [medline] PHST- 2004/09/01 05:00 [entrez] AID - S0149291804901750 [pii] AID - 10.1016/s0149-2918(04)90175-0 [doi] PST - ppublish SO - Clin Ther. 2004 Jul;26(7):1037-45. doi: 10.1016/s0149-2918(04)90175-0. PMID- 17510712 OWN - NLM STAT- MEDLINE DCOM- 20070926 LR - 20210227 IS - 0033-6572 (Print) IS - 0033-6572 (Linking) VI - 38 IP - 2 DP - 2007 Feb TI - Interfacial morphology of self-etching adhesive systems in dentin. PG - e112-9 AB - OBJECTIVE: To portray and assess the interfacial morphology achieved with self-etching systems in dentin under observation by scanning electron microscopy. METHOD AND MATERIALS: Ten caries-free extracted erupted human third molars were used in this study. The occlusal enamel was removed, and 10 dentin disks with a thickness of 800 +/- 200 Microm were obtained by slow-speed sectioning with a diamond saw parallel to the occlusal surface. A standard smear layer was created on the occlusal surface by wet sanding with 600-grit sandpaper for 60 seconds. The dentin disks were randomly assigned to one of the systems: AdheSE (Ivoclar Vivadent), Optibond Solo Plus-Self-Etch (Kerr), Tyrian SPE (Bisco) as self-etching primers, and Adper Prompt Self-Etch (3M Espe) and One-Up Bond F (Tokuyama) as self-etching adhesives. All systems were applied according to the manufacturers' instructions. After application of the adhesive systems, a 1.0-mm-thick layer of a flowable composite resin (Filtek Flow; 3M Espe) was applied to the treated dentin surface and light cured for 40 seconds. The specimens were then processed for observation by scanning electron microscopy. RESULTS: All self-etching systems achieved the formation of sealed interfaces and hybridized areas with variable extents except for the self-etching adhesive One-Up Bond F, which showed some gap formation and poor hybridization. Optibond Solo Plus-Self-Etch presented a more consistent adhesive interface with thicker hybrid layers, numerous resin tags, and lateral branches. CONCLUSION: Regarding the micromorphology aspect, Optibond Solo Plus-Self-Etch showed the finest result, while One-Up Bond F was not able to produce a satisfactory ultrastructural morphology. FAU - Sensi, Luis Guilherme AU - Sensi LG AD - Department of Endodontics, Prosthodontics, and Operative Dentistry, University of Maryland Dental School, Baltimore, MD, USA. lsensi@umaryland.edu FAU - Marson, Fabiano Carlos AU - Marson FC FAU - Belli, Renan AU - Belli R FAU - Baratieri, Luiz Narciso AU - Baratieri LN FAU - Monteiro, Sylvio Jr AU - Monteiro S Jr LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 RN - 0 (Dentin-Bonding Agents) SB - D MH - Acid Etching, Dental/methods MH - Dental Bonding/*methods MH - Dentin/*ultrastructure MH - Dentin-Bonding Agents/*chemistry MH - Humans MH - Molar MH - Surface Properties EDAT- 2007/05/19 09:00 MHDA- 2007/09/27 09:00 CRDT- 2007/05/19 09:00 PHST- 2007/05/19 09:00 [pubmed] PHST- 2007/09/27 09:00 [medline] PHST- 2007/05/19 09:00 [entrez] AID - 839758 [pii] PST - ppublish SO - Quintessence Int. 2007 Feb;38(2):e112-9. PMID- 33339976 OWN - NLM STAT- MEDLINE DCOM- 20210202 LR - 20210202 IS - 1476-5446 (Electronic) IS - 1462-0049 (Linking) VI - 21 IP - 4 DP - 2020 Dec TI - Limited evidence suggests complete arch digital scans are less time efficient than conventional impression. PG - 138-139 LID - 10.1038/s41432-020-0143-1 [doi] AB - Source of funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectorsType of study/design Randomised controlled trial (RCT) with parallel design.Subjects This RCT was conducted at the Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Centre of Dental Medicine, University of Zurich, Zurich, Switzerland. Ten patients, six women and four men, with a mean age of 62 years and an age range of 49-77 years, requiring posterior tooth-supported 3-unit fixed partial dentures (FPDs) were included in this RCT. The abutment teeth were six molars and six premolars in the maxilla and five molars and three premolars in the mandible. The patients fulfilled the following inclusion criteria: they all were >18 years, with a full mouth plaque score <25% and a full mouth bleeding score <25%. They all needed a posterior tooth-supported FPD, in which the third molar was not an abutment tooth. Only abutments with no extensive pretreatment were eligible. Adjacent and opposing teeth should be healthy or adequately restored.Treatment Three intraoral digital scanning systems (Lava C.O.S.; 3M [Lava], iTero; Align Technology Inc [iTero], Cerec Bluecam; Dentsply Sirona [Cerec]) and conventional light/regular body polyether impression in a stock tray were made on each of the included participants by the same clinician. The opposing arch impression was made in alginate. The sequence of the four techniques was computer generated and concealed in opaque sealed envelopes. Three calibrated experienced clinicians were involved in the treatment. They followed the published guidelines for preparing abutments that receive CAD/CAM ceramic FPDs. After interim prosthesis removal and double retraction cord application, the digital or the conventional impression procedure was started as dictated by the random sequence. Scans were done according to the manufacturer's guidelines, whereby Lava and Cerec required powdering of the teeth by titanium oxide and iTero did not.Main outcome Time needed for obtaining a scan or an impression was calculated. For digital scans it consisted of the time required for powdering, scanning and occlusal registration, while in conventional impression it started from the beginning of impression mixing till tray removal. The number of impression or scan remakes required until results fulfilling the quality criteria were obtained was also recorded. Visual analogue scale (VAS) was used to rate the perception of both, clinicians and patients for the procedures. Patients were asked to rate their comfort with the procedure, while clinicians rated both difficulty and comfort, where 0 indicated uncomfortable and simple and 100 difficult and comfortable. Subjective assessment of the time as judged by the clinicians and the patients was also reported.Main results Generally speaking, conventional impression was better than the three complete arch digital scans, regarding time required in seconds, difficulty for clinicians, comfort and time perception of both patients and clinicians. Number of remakes were highest in iTero (7), followed by Lava, conventional impression and finally Cerec (0). The time required for each technique differed significantly Polyether = 658 (95%CI 528-782) Cerec = 1776 (95%CI 804-2386) iTero = 1107 (785 - 2091). A significant difference was found neither among the three digital impressions, nor between the conventional impression and Lava (μ = 1091, 95%CI [717-1465]). The same findings were reported regarding difficulty for the clinicians. A significant difference was reported between conventional impression (μ = 15, 95%CI [7-24]) and both Cerec (μ = 67, 95%CI [58-77]) and iTero (μ = 43, 95%CI [25-62]). No significant difference was reported among the studied techniques regarding patients' comfort and time perceptions of both clinicians and patients except for a difference in the patients' time perception of Cerec and conventional impression, where P = .035. Regarding the clinicians' comfort a significant difference was only found between conventional impression (μ = 82, 95%CI [69-94]) and Cerec (μ = 32, 95%CI [18-46]).Conclusion Within the limitations of this RCT, it can be concluded that complete arch conventional impression is objectively less time consuming and subjectively preferred by both clinicians and patients when compared to digital scanning. Digital scanning techniques, requiring powdering, are more difficult for the clinicians than powderless ones and conventional impression. FAU - Sedky, Arwa AU - Sedky A AD - PhD candidate, Faculty of Dentistry, Cairo University, Egypt. FAU - Abd-Elwahab Radi, Iman AU - Abd-Elwahab Radi I AD - Professor of Prosthodontics and Member of the Evidence Based Dentistry Centre, Faculty of Dentistry, Cairo University, Egypt. iman.abdelwahab@dentistry.cu.edu.eg. LA - eng PT - Comment PT - Journal Article PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Dental Impression Materials) RN - C6V6S92N3C (Zirconium) RN - S38N85C5G0 (zirconium oxide) SB - D SB - IM CON - J Prosthet Dent. 2019 Jan;121(1):69-75. PMID: 30017152 MH - Aged MH - Ceramics MH - *Dental Impression Materials MH - *Dental Impression Technique MH - Denture, Partial, Fixed MH - Female MH - Humans MH - Male MH - Middle Aged MH - Switzerland MH - Workflow MH - Zirconium EDAT- 2020/12/20 06:00 MHDA- 2021/02/03 06:00 CRDT- 2020/12/19 05:27 PHST- 2020/12/19 05:27 [entrez] PHST- 2020/12/20 06:00 [pubmed] PHST- 2021/02/03 06:00 [medline] AID - 10.1038/s41432-020-0143-1 [pii] AID - 10.1038/s41432-020-0143-1 [doi] PST - ppublish SO - Evid Based Dent. 2020 Dec;21(4):138-139. doi: 10.1038/s41432-020-0143-1. PMID- 14651279 OWN - NLM STAT- MEDLINE DCOM- 20040204 LR - 20131121 IS - 0099-2399 (Print) IS - 0099-2399 (Linking) VI - 29 IP - 11 DP - 2003 Nov TI - Direct capping with four different materials in humans: histological analysis of odontoblast activity. PG - 729-34 AB - Pulp inflammation in restored teeth is mainly due to the presence of bacteria or bacterial products introduced by microleakage around the restoration or to the material toxicity. Recent knowledge has permitted a precise identification of the risks for pulpal irritation associated with adhesive materials and procedures. The purpose of this work was to evaluate the cellular events that occur in direct pulp exposure capped using different materials. Twenty-four vital teeth without caries, scheduled for extraction for orthodontic reasons, were selected. After a control of the hemostasis, each pulp was directly capped with a different material. The samples were randomly divided into four groups of six specimens each: group I: dental-bonding agent (Solist) followed by resin composite (Ecusit); group II: dental adhesive (Prompt) and resin composite (Pertac II); group III: traditional calcium hydroxide (Dycal) plus resin composite (Ecusit); group IV: light-curing calcium hydroxide (Ultrablend Plus) and amalgam (Dentsply). After 15 days the teeth were extracted, immediately fixed in 10% buffered formalin, embedded in resin (7200 Technovit), and prepared for thin ground sections with Precise 1 System. In the specimens of all groups, there were active odontoblasts near the composite resins and no newly formed dentin. Small quantities of inflammatory cells were present. A 1- to 3-microm layer zone of necrosis was present. In conclusion, all materials tested in this study induced similar tissue responses. FAU - Scarano, Antonio AU - Scarano A AD - Dental School, University of Chieti, Italy. FAU - Manzon, Licia AU - Manzon L FAU - Di Giorgio, Roberto AU - Di Giorgio R FAU - Orsini, Giovanna AU - Orsini G FAU - Tripodi, Domenico AU - Tripodi D FAU - Piattelli, Adriano AU - Piattelli A LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Endod JT - Journal of endodontics JID - 7511484 RN - 0 (Composite Resins) RN - 0 (Dental Materials) RN - 0 (Dentin-Bonding Agents) RN - 0 (Ecusit-Mono) RN - 0 (Methacrylates) RN - 0 (Minerals) RN - 0 (Organic Chemicals) RN - 0 (Pertac-Bond) RN - 0 (Prompt L-Pop) RN - 0 (Resin Cements) RN - 0 (solist) RN - 138362-23-9 (Ultrablend) RN - 3IN71E75Z5 (Urethane) RN - 54479-90-2 (Dycal) RN - 8049-85-2 (Dental Amalgam) RN - PF5DZW74VN (Calcium Hydroxide) SB - D MH - Analysis of Variance MH - Calcium Hydroxide/chemistry MH - Composite Resins/chemistry MH - Dental Amalgam/chemistry MH - Dental Materials/*chemistry MH - *Dental Pulp Capping MH - Dental Pulp Exposure/therapy MH - Dentin/pathology MH - Dentin-Bonding Agents/chemistry MH - Humans MH - Methacrylates/chemistry MH - Minerals/chemistry MH - Necrosis MH - Odontoblasts/*pathology MH - Organic Chemicals MH - Resin Cements/chemistry MH - Urethane/chemistry EDAT- 2003/12/04 05:00 MHDA- 2004/02/05 05:00 CRDT- 2003/12/04 05:00 PHST- 2003/12/04 05:00 [pubmed] PHST- 2004/02/05 05:00 [medline] PHST- 2003/12/04 05:00 [entrez] AID - S0099-2399(05)60363-9 [pii] AID - 10.1097/00004770-200311000-00011 [doi] PST - ppublish SO - J Endod. 2003 Nov;29(11):729-34. doi: 10.1097/00004770-200311000-00011. PMID- 15220011 OWN - NLM STAT- MEDLINE DCOM- 20040903 LR - 20190922 IS - 0149-2918 (Print) IS - 0149-2918 (Linking) VI - 26 IP - 5 DP - 2004 May TI - Etoricoxib in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. PG - 667-79 AB - BACKGROUND: Patients experiencing acute pain after surgery, including dental surgery, often require analgesia. Ideally, the chosen analgesic should have a rapid onset and sustained effect. Etoricoxib is a new cyclooxygenase-2-selective inhibitor that has demonstrated analgesic efficacy in the treatment of acute pain with a rapid onset and long-lasting pain relief. OBJECTIVE: The goal of this study was to determine the analgesic effect of single oral doses of etoricoxib 60, 120, 180, and 240 mg compared with placebo in the treatment of pain after dental surgery. Ibuprofen was used as an active control. METHODS: This was a randomized, double-blind, parallel-group, single-dose, placebo- and active comparator-controlled study performed at a single center. It consisted of 3 visits (prestudy, treatment, and poststudy). Eligible patients were aged > or =16 years with moderate or severe pain after surgical extraction of > or =2 third molars, of which > or =1 was an impacted mandibular molar. Patients were assessed over 24 hours and reported pain intensity and pain relied at 14 predefined time points. Plasma samples for a pharmacokinetic/pharmacodynamic analysis were collected from a subset of patients at baseline and the 14 predefined time points. The end points included total pain relief over 8 hours (TOPAR8, the primary end point), sum of pain intensity difference over 8 hours, patient's global evaluation of treatment, median time to onset of pain relief (2-stopwatch method), peak pain relief, and duration of analgesic effect (median time to use of rescue medication). Adverse events were collected up to 14 days postdose. RESULTS: Three hundred ninety-eight (63.1% women, 36.9% men; mean age, 21.1 years; 72.1% white, 27.9% other; mean number of third molars removed, 3.5; 65.2% experiencing moderate pain) were randomly allocated to receive etoricoxib 60 mg (n = 75), etoricoxib 120 mg (n = 76), etoricoxib 180 mg (n = 74), etoricoxib 240 mg (n = 76), ibuprofen 400 mg (n = 48), and placebo (n = 49). All active treatments had significantly greater overall analgesic effect (TOPAR8) compared with placebo (P < or 0.001). Patients who received etoricoxib 120 and 180 mg had significantly higher TOPAR8 scores than those who received etoricoxib 60 mg ( P < = 0.001) and ibuprofen (P < 0.05 etoricoxib 120 mg; P < or = 0.001 etoricoxib 180 mg). Least-squares mean TOPAR8 scores for etoricoxib 60, 120, 180, and 240 mg, ibuprofen, and placebo were 16.0, 22.0, 23.5, 20.7, 18.6, and 5.2, respectively. The median time to onset of analgesia was 24 minutes for etoricoxib 120, 180, and 240 mg, and 30 minutes for etoricoxib 60 mg and ibuprofen. There were no significant differences in the onset of analgesia between etoricoxib 120, 180, and 240 mg and ibuprofen. The duration of analgesic effect was >24 hours for etoricoxib 120, 180, and 240 mg, and 12.1 hours for etoricoxib 60 mg. The duration of effect was significantly longer with all 4 etoricoxib doses compared with ibuprofen (10.1 hours; P < 0.05 etoricoxib 60 mg; < or = 0.001etoricoxib 120, 180, and 240 mg) and compared with placebo (2.1 hours; P < = 0.001). In the pharmacokinetic/pharmacodynamic analysis (n approximately 120), there was a linear relationship between plasma etoricoxib concentrations and pain relief scores up to the maximum observed concentration, followed by a decline in plasma concentrations with persistent analgesia. The most common adverse events were postextraction alveolitis and nausea. CONCLUSIONS: In this dose-ranging study, etoricoxib 120 mg was determined to be the minimum dose that had maximal efficacy in patients with moderate to severe acute pain associated with dental surgery. Both etoricoxib and ibuprofen were generally well tolerated. FAU - Malmstrom, Kerstin AU - Malmstrom K AD - Merck Research Laboratories, Rahway, New Jersey, USA. FAU - Sapre, Aditi AU - Sapre A FAU - Couglin, Heather AU - Couglin H FAU - Agrawal, Nancy G B AU - Agrawal NG FAU - Mazenko, Ralph S AU - Mazenko RS FAU - Fricke, James R Jr AU - Fricke JR Jr LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Isoenzymes) RN - 0 (Membrane Proteins) RN - 0 (Pyridines) RN - 0 (Sulfones) RN - EC 1.14.99.1 (Cyclooxygenase 2) RN - EC 1.14.99.1 (PTGS2 protein, human) RN - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases) RN - WRX4NFY03R (Etoricoxib) SB - IM MH - Adolescent MH - Adult MH - Cyclooxygenase 2 MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Etoricoxib MH - Female MH - Humans MH - Isoenzymes/*antagonists & inhibitors MH - Male MH - Membrane Proteins MH - Pain, Postoperative/*drug therapy/etiology MH - Prostaglandin-Endoperoxide Synthases MH - Pyridines/*administration & dosage/pharmacokinetics/*therapeutic use MH - Sulfones/*administration & dosage/pharmacokinetics/*therapeutic use MH - Tooth Extraction/*adverse effects EDAT- 2004/06/29 05:00 MHDA- 2004/09/04 05:00 CRDT- 2004/06/29 05:00 PHST- 2004/02/20 00:00 [accepted] PHST- 2004/06/29 05:00 [pubmed] PHST- 2004/09/04 05:00 [medline] PHST- 2004/06/29 05:00 [entrez] AID - S0149291804900677 [pii] AID - 10.1016/s0149-2918(04)90067-7 [doi] PST - ppublish SO - Clin Ther. 2004 May;26(5):667-79. doi: 10.1016/s0149-2918(04)90067-7. PMID- 29996359 OWN - NLM STAT- MEDLINE DCOM- 20180802 LR - 20181202 IS - 1002-0098 (Print) IS - 1002-0098 (Linking) VI - 53 IP - 7 DP - 2018 Jul 9 TI - [Caries prevention effectiveness of aresin based sealant and a glass ionomer sealants: a report of 5-year-follow-up]. PG - 437-442 LID - 10.3760/cma.j.issn.1002-0098.2018.07.002 [doi] AB - Objective: To evaluate and compare the caries prevention effectiveness of a resin-based sealant and a glass ionomer sealant on permanent first molars in 7- to 9-years-old school children. Methods: A randomized controlled, examiner-blinded, 5-year clinical trial was conducted in 19 primary schools in Dalian, Liaoning province. Totally 419 children (with 664 first molars) who had at least one sound permanent first molar with deep fissures or fissures with signs of non-cavitated lesions were recruited and stratified and allocated randomly into three parallel groups. A resin-based sealant was used in Group R (136 children with 219 first molars) and a glass ionomer sealant was used in Group G (130 children with 218 first molars). The third group (Group N, 153 children with 227 first molars) with none of the two sealants applied was served as blank control. Follow-up examinations were conducted at 0.5, 1, 2, and 5 years after sealing in order to assess the retention of the sealants and the incidence of caries occurrence. Chi-square test was adopted to compare the differences of caries incidence among the 3 groups. Generalized estimating equations (GEE) was used to analyze the effective factors of caries incidence. Results: During the 5-year follow-up period, 13.4% (23/172) of the teeth in Group R, 22.5% (40/178) of the teeth in Group G and 34.5% (57/165) of the teeth in Group N were diagnosed as having developed cavitated lesions. And the differences in the incidence of caries among the three groups was statistically significant (P<0.05). According to GEE, the resin-based sealant and the glass ionomer sealant were found to be the protection factors and the non-cavitated lesion before sealing was found to be the risk factor. The resin-based sealant was found to be the protection factor to the glass ionomer sealant when the blank control group was removed. Conclusions: Both resin-based sealant and glass ionomer sealant could effectively prevent the permanent first molars from the occurrence of carious lesions in 5 years. The resin-based sealant was superior to the glass ionomer sealant in caries prevention. FAU - Liu, Y J AU - Liu YJ AD - Department of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China (Present address: Arrail-Dental, Beijing 100014, China). FAU - Chang, Q AU - Chang Q AD - Second Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100101, China. FAU - Rong, W S AU - Rong WS AD - Department of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. FAU - Zhao, X L AU - Zhao XL AD - Department of Stomatology, Dalian Development Area Hospital, Dalian Liaoning 116600, China. LA - chi PT - Journal Article PT - Randomized Controlled Trial PL - China TA - Zhonghua Kou Qiang Yi Xue Za Zhi JT - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology JID - 8711066 RN - 0 (Acrylic Resins) RN - 0 (Glass Ionomer Cements) RN - 0 (Pit and Fissure Sealants) RN - 0 (glass ionomer) RN - 7631-86-9 (Silicon Dioxide) SB - D SB - IM MH - Acrylic Resins/*therapeutic use MH - Child MH - Dental Caries/*prevention & control MH - Follow-Up Studies MH - Glass Ionomer Cements/*therapeutic use MH - Humans MH - Molar MH - Pit and Fissure Sealants/*therapeutic use MH - Silicon Dioxide/*therapeutic use MH - Time Factors OTO - NOTNLM OT - Caries prevention OT - Dental caries OT - Fissure sealants OT - Molars EDAT- 2018/07/13 06:00 MHDA- 2018/08/03 06:00 CRDT- 2018/07/12 06:00 PHST- 2018/07/12 06:00 [entrez] PHST- 2018/07/13 06:00 [pubmed] PHST- 2018/08/03 06:00 [medline] AID - 10.3760/cma.j.issn.1002-0098.2018.07.002 [doi] PST - ppublish SO - Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Jul 9;53(7):437-442. doi: 10.3760/cma.j.issn.1002-0098.2018.07.002. PMID- 23053702 OWN - NLM STAT- MEDLINE DCOM- 20140619 LR - 20191210 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 17 IP - 6 DP - 2013 Jul TI - Validation and spectrophotometric analysis of crown discoloration induced by root canal sealers. PG - 1525-33 LID - 10.1007/s00784-012-0850-x [doi] AB - OBJECTIVES: A major cause of crown discoloration is root canal sealer remnants in the pulp chamber, after root canal obturation. The aim of this study was the evaluation of the chromogenic effect of common and new-generation root canal sealers. The tested null hypothesis was that none of the sealers induced clinically perceptible crown discoloration, ex vivo (H(0): CIE color difference ∆Ε < 3.7). METHODS: The crowns of 80 intact, fully developed third mandibular molars were cross-sectioned 1 mm below the cementoenamel junction and stored in standard conditions (100 % humidity, 37 °C). The pulp chambers were chemomechanically debrided with hand files and sodium hypochlorite (NaOCl) and the specimens were randomly assigned into four experimental (1-4) and one control (5) groups. In the experimental groups, the internal axial walls of the pulp chambers were coated with sealers (Group 1; Roth 811, Group 2; AH26, Group 3; GuttaFlow, Group 4; Epiphany SE). The pulp chambers of the control group (Group 5) remained unfilled. The spectral reflectance lines of the crowns were recorded by a UV-Vis spectrophotometer. CIE total color differences [Formula: see text] were calculated after 1 week, 1 month, 3 months, and 6 months, respectively. A pilot study was also conducted for the validation of the experimental model. Two-way mixed ANOVA models were used for statistical data analysis. RESULTS: The experimental model presented values of ∆Ε < 1 unit and high positive correlation values, after repeated measurements (p < 0.05). Roth 811 sealer (Group 1) induced clinically perceptible crown discoloration (∆Ε > 3.7, p < 0.05) and presented statistically significant differences from Groups 2-5 in all examination intervals (p < 0.05). In Groups 2-5, clinically perceptible crown discoloration was not observed (∆Ε < 3.7, p < 0.05). CONCLUSIONS: Roth 811 sealer exhibited severe discoloration effects. Within the limitations of this study, it can be concluded that any sealer remnants should be removed from the pulp chamber after root canal obturation and before placement of a final restoration. CLINICAL RELEVANCE: The chromogenic potential may play an important role in selecting proper root canal sealers. FAU - Ioannidis, Konstantinos AU - Ioannidis K AD - pabloioannidis@yahoo.com FAU - Beltes, Panagiotis AU - Beltes P FAU - Lambrianidis, Theodor AU - Lambrianidis T FAU - Kapagiannidis, Dimitrios AU - Kapagiannidis D FAU - Karagiannis, Vassilis AU - Karagiannis V LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Validation Study DEP - 20120930 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Chromogenic Compounds) RN - 0 (Dimethylpolysiloxanes) RN - 0 (Drug Combinations) RN - 0 (Epoxy Resins) RN - 0 (GuttaFlow) RN - 0 (Root Canal Filling Materials) RN - 0 (Root Canal Irrigants) RN - 0 (Zinc Oxide-Eugenol Cement) RN - 0 (epiphany sealer) RN - 3M4G523W1G (Silver) RN - 55599-25-2 (epoxy resin AH-26) RN - 69234-10-2 (Roth's 811 sealer) RN - 9000-32-2 (Gutta-Percha) RN - D1JT611TNE (Titanium) RN - DY38VHM5OD (Sodium Hypochlorite) RN - U015TT5I8H (Bismuth) SB - D MH - Bismuth/adverse effects MH - Chromogenic Compounds/adverse effects MH - Color MH - Dental Pulp Cavity/drug effects MH - Dimethylpolysiloxanes/adverse effects MH - Drug Combinations MH - Epoxy Resins/adverse effects MH - Gutta-Percha/adverse effects MH - Humans MH - Materials Testing MH - Molar/drug effects MH - Pilot Projects MH - Root Canal Filling Materials/*adverse effects MH - Root Canal Irrigants/therapeutic use MH - Root Canal Preparation/instrumentation/methods MH - Silver/adverse effects MH - Sodium Hypochlorite/therapeutic use MH - Spectrophotometry, Ultraviolet/methods MH - Time Factors MH - Titanium/adverse effects MH - Tooth Crown/*drug effects MH - Tooth Discoloration/*chemically induced MH - Zinc Oxide-Eugenol Cement/adverse effects EDAT- 2012/10/12 06:00 MHDA- 2014/06/20 06:00 CRDT- 2012/10/12 06:00 PHST- 2012/01/16 00:00 [received] PHST- 2012/09/19 00:00 [accepted] PHST- 2012/10/12 06:00 [entrez] PHST- 2012/10/12 06:00 [pubmed] PHST- 2014/06/20 06:00 [medline] AID - 10.1007/s00784-012-0850-x [doi] PST - ppublish SO - Clin Oral Investig. 2013 Jul;17(6):1525-33. doi: 10.1007/s00784-012-0850-x. Epub 2012 Sep 30.