>Human_Homo:sapiens_ENSG00000090674_Chr19_Vertebrata_MCOLN1 ------------------------------------------------------------ ----------------------------------MTAPAG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PRGSETE------------------------------ -----------------------------------RLLT--------------------- ------------------------------------------------------------ ---PNPGY-GTQAGPSPA------------------------------------------ ------------------------------------------------------------ -----------P-----------------------PTP------PEEEDLRR-------- ---------------------------RLKYFFMS----------------------PCD KFRAKG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPCKLM-----------------------------------LQVVKI LVVTVQLILFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QLAVTFR----E------------------------ ------------------------------------------------------------ --------------------ENTIAFRHLFLLG----Y--SDGAD--------------- --------------------DTFAAYTREQLYQAIFHAVD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYLALPDVS-----------------------------------L------- ---GRYAYVR---GGGD------------------PWTNGSGL----------------- -----------------------------ALC--------QRYYHRGHVDPA-------- ----------------------------------------------NDTFDIDPMVVTDC IQVDP-PERPP-PPPSDDLTL-----L--------------------ESSSSYKNLTLKF H--------------------------------------KLVNVTIH-----FRLKTINL QSLINNEIPDCYTFSV-------------------------------------------- -------------------------------------LITF------------------- ----------------------------------DNKAHSGRIPISLETQAHI------- --------------------------QE-------------------------------- ------------------------------------------------------------ ----CKHPSVFQHGD-N-SF----------------------RLLFDVVVILTCS----- ----LSFLL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CA RSLLRGFLLQNEFVGFMWRQRGRV----------------------------IS------ -----------------------------LWERLE------FVNGWYILLVTSDVLTISG TIM-KIGIEAK------------NLASYDVCSILL------------------------- ---GTSTLLVWVGVIRYL-TFFHNYNILIATLRVAL-PSVMRFCCCVAVIYLGYCFCGWI VLGPYHV-------------------------------------------KF------RS LSMVSECLFSLINGDDM--------FVTFA----------------------AMQAQQG- -------------------------------------------------------RSSLV WLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGA-------------------- ---GAEESELQAYIAQC----QDSPTSGKFRRGS-------------------------- ----------------------------GSAC---------------------------- ----------------SLLCC------------------CGR------------------ -------------------------------------------DPSEEHS-L-------- --------------------------------------L--------------------- ------------------------------------------------------VN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Human_Homo:sapiens_ENSG00000153898_Chr1_Vertebrata_MCOLN2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MARQ------------------------------ -----------------------------------PY----------------------- ------------------------------------------------------------ ---RFPQARIPERGSGVFRLTVR------------------------------------- ------------------------------------------------------------ -----------------------------------NAMAHRDSEMKEECLRE-------- ---------------------------DLKFYFMS----------------------PCE KYRARR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QIPWKLG-----------------------------------LQILKI VMVTTQLVRFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QLVVAFK----E------------------------ ------------------------------------------------------------ --------------------DNTVAFKHLFLKG----YSGTDEDD--------------- --------------------YSCSVYTQEDAYESIFFAIN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYHQLKDIT-----------------------------------L------- ---GTLGYGE---NED----------------------NRIGL----------------- -----------------------------KVC--------KQHYKKGTMFPS-------- ----------------------------------------------NETLNIDNDVELDC VQLD--LQDLS-KKPPDW------------------------------K--NSSFFRLEF Y--------------------------------------RLLQVEIS-----FHLKGIDL QTIHSRELPDCYVFQN-------------------------------------------- -------------------------------------TIIF------------------- ----------------------------------DNKAHSGKIKIYFDSDAKI------- --------------------------EE-------------------------------- ------------------------------------------------------------ ----CKDLNIFGSTQKNAQY----------------------VLVFDAFVIVICL----- ----ASLIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CT RSIVLALRLRKRFLNFFLEKYKRP----------------------------VC------ -----------------------------DTDQWE------FINGWYVLVIISDLMTIIG SIL-KMEIKAK------------NLTNYDLCSIFL------------------------- ---GTSTLLVWVGVIRYL-GYFQAYNVLILTMQASL-PKVLRFCACAGMIYLGYTFCGWI VLGPYHD-------------------------------------------KF------EN LNTVAECLFSLVNGDDM--------FATFA----------------------QIQQK--- --------------------------------------------------------SILV WLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQN-------------------- ---GFPETDLQEFLKEC----SSKEEYQKE------------------------------ ------------------------------SS---------------------------- ----------------AFLSCI----------------CCRRR----------------- -------------------------------------------KRSDDHL-I-------- --------------------------------------P--------------------- ------------------------------------------------------IS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Human_Homo:sapiens_ENSG00000055732_Chr1_Vertebrata_MCOLN3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MADP------------------------------ -----------------------------------EVVV--------------------- ------------------------------------------------------------ ---SSCSS-HEEENRCNFNQQT-------------------------------------- ------------------------------------------------------------ --------------------------------------SPSEELLLEDQMRR-------- ---------------------------KLKFFFMN----------------------PCE KFWARG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPWKLA-----------------------------------IQILKI AMVTIQLVLFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVAFK----E------------------------ ------------------------------------------------------------ --------------------ENTIAFKHLFLKG----Y--MDRMD--------------- --------------------DTYAVYTQSDVYDQLIFAVN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYLQLYNVS-----------------------------------V------- ---GNHAYEN---KGT----------------------KQSAM----------------- -----------------------------AIC--------QHFYKRGNIYPG-------- ----------------------------------------------NDTFDIDPEIETEC FFVEP-DEPFH-IGTPA---------------------------------ENKLNLTLDF H--------------------------------------RLLTVELQ-----FKLKAINL QTVRHQELPDCYDFTL-------------------------------------------- -------------------------------------TITF------------------- ----------------------------------DNKAHSGRIKISLDNDISI------- --------------------------RE-------------------------------- ------------------------------------------------------------ ----CKDWHVSGSIQKNTHY----------------------MMIFDAFVILTCL----- ----VSLIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CI RSVIRGLQLQQEFVNFFLLHYKKE----------------------------VS------ -----------------------------VSDQME------FVNGWYIMIIISDILTIIG SIL-KMEIQAK------------SLTSYDVCSILL------------------------- ---GTSTMLVWLGVIRYL-GFFAKYNLLILTLQAAL-PNVIRFCCCAAMIYLGYCFCGWI VLGPYHD-------------------------------------------KF------RS LNMVSECLFSLINGDDM--------FATFA----------------------KMQQK--- --------------------------------------------------------SYLV WLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQD-------------------- ---GFPETELRTFISEC----KDLPNSGKYRLED-------------------------- ----------------------------DPPV---------------------------- ----------------SLFCC------------------CKK------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006002982.1_NW:005819879.1_Vertebrata_MCOLN1_MCOLN1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MDKTESD------------------------------ -----------------------------------RLLT--------------------- ------------------------------------------------------------ ---SVNNY-GSQ----DSLEVHF------------------------------------- ------------------------------------------------------------ ---------------------------------------LSVLQREEEALRR-------- ---------------------------KLKYFFMS----------------------PCD KYRAKS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPYKLV-----------------------------------LQLLKI AFVTVQLVLFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVAFK----E------------------------ ------------------------------------------------------------ --------------------ENTISFKHLFLKD----Y--SDGAD--------------- --------------------DTYAVYTQSDTYDYIYYTVD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QFLTLPNTT-----------------------------------V------- ---GRYAYVL---DKG---------------------VNHSAL----------------- -----------------------------MLC--------QHYYKKGRIDPA-------- ----------------------------------------------NDTFNIDPQIITAC VGVNP-LTRTY-DSEDMD--------------------------------PTYKNFTLKF H--------------------------------------KLINVTIQ-----FKLKAINI QTIINNEIPDCYTFVI-------------------------------------------- -------------------------------------TITF------------------- ----------------------------------DNKAHSGKIKIRLENEADI------- --------------------------KE-------------------------------- ------------------------------------------------------------ ----CKDPNIYGHGD-N-YA----------------------RFMFDVLVIILCI----- ----LSFTL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CV RSTVRGVMLQNECMHYFQRRYNKQ----------------------------LS------ -----------------------------LSDRLE------FVNGWYILLIISDILTVIG SVM-KIGIESK------------TFANYDVCSILL------------------------- ---GTSTLLIWVGVIRYL-SFFQKYNILIVTLRAAF-PNVMRFCFCAAVIYLGYCFCGWI VLGPYHI-------------------------------------------KF------RS LSMVSECLFSLINGDDM--------FTTFS----------------------EMQQS--- --------------------------------------------------------SYLV WLFSQVYLYTFISLFIYMVLSLFIALITGSYEAIKNQRKE-------------------- ---EQHITELHAFIAQC----QDTPNSGMFRGPE-------------------------- ----------------------------ESAC---------------------------- ----------------SILCC------------------CDR------------------ -------------------------------------------PTTYEDT-L-------- --------------------------------------V--------------------- ------------------------------------------------------VN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014342647.1_NW:005819194.1_Vertebrata_MCOLN1_MCOLN2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MDITNEEQFLRE-------- ---------------------------DLKYYFMN----------------------PCE KFRARR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QIPWKLG-----------------------------------LQVLKI VMVTTQLVLFGLN----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QLVVSFK----E------------------------ ------------------------------------------------------------ --------------------ENSKAFKHLFLKG----YKGIDEDD--------------- --------------------YSCSVFTQQDVYESMYFVID-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYQQLKNLS-----------------------------------L------- ---GTLGYEY---DED----------------------KKAVL----------------- -----------------------------KIC--------KKQYKRGKIVPS-------- ----------------------------------------------NDSFDIEPTIETDC LNIEP-VTSAK-KNSAVW------------------------------RMSNTSFYNLEF Y--------------------------------------RLVQVEIT-----FKLKGIDL QTIQARELPDCYEFYL-------------------------------------------- -------------------------------------SIIF------------------- ----------------------------------DNQAHSGIVKIYFDSDAFL------- --------------------------QE-------------------------------- ------------------------------------------------------------ ----CKDWHISGSIQKNTHY----------------------ILIFDGFIILICL----- ----VSLIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CI RSIVLALKLKERCSKFFVEKYNTF----------------------------VS------ -----------------------------RGDCLE------FVNGWYILIIISDLMTITG SIM-KMEIKAK------------SLTSYDVCSILL------------------------- ---GTSTLLVWVGVIRYL-GYFQKYNVLILTMRASF-PKMLRFCCCAGMIYLGYTFCGWI VLGPYHE-------------------------------------------KF------EN LNKVSECLFSLINGDDM--------FATFA----------------------QFQQK--- --------------------------------------------------------STLV WLFSRLYLYSFISVFIYMVLSLFIALITDSYETIKKYQQN-------------------- ---GFPETKLHTFLAES----NTISGIGRRGLEK-------------------------- ----------------------------GITN---------------------------- ----------------TFLCC------------------CGSQ----------------- -------------------------------------------QRSDDDL-V-------- --------------------------------------F--------------------- ------------------------------------------------------INEY-- ----------------------------NLKHHSTK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014342640.1_NW:005819194.1_Vertebrata_MCOLN1_MCOLN3 ------------------------------------------------------------ ----------------------------------MYRTANS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------VSEMENP------------------------------ -----------------------------------ELVV--------------------- ------------------------------------------------------------ ---NSCGS-HDDGSHCICKQNL-------------------------------------- ------------------------------------------------------------ --------------------------------------------VEEDQLRR-------- ---------------------------KLKFFFMN----------------------PCE KFSARG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPWKLG-----------------------------------LQILKI AMVSIQLVLFGLS----------------------------------------------- --------------------------H--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVAFK----E------------------------ ------------------------------------------------------------ --------------------ENTIAFKHLFLKE----Y--ADRVD--------------- --------------------DTYAVYTQADVYDHISFVIN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RYLKLSHIS-----------------------------------V------- ---GNHAYER---KGT----------------------NLTAM----------------- -----------------------------RLC--------QNFYAKGSICPG-------- ----------------------------------------------NDTFDIDPKVETEC FEIEP-LMTTD-DGTLQ---------------------------------ENKLNLSLDF H--------------------------------------RLLKVQIE-----FRLKAINL QTVRHHELPDCYDFTV-------------------------------------------- -------------------------------------MITF------------------- ----------------------------------DNKAHSGRIKINLENDVGI------- --------------------------RE-------------------------------- ------------------------------------------------------------ ----CREWHVSGSMQRNTHY----------------------MMIFDAFVIAVCL----- ----SSLIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CT RSVVKGIKLQNEFVDFFEQHYNKQ----------------------------VS------ -----------------------------WSDRME------FVNGWYILIIICDVLTMIG SIM-KMEIEVK------------SLTSYDVCSILL------------------------- ---GTSTLLVWVGVIRYL-GFFQKYNLLILTLRAAF-PNVVRFCCCAAMIYLGYCFCGWI VLGPYHS-------------------------------------------KF------RS LNVVSECLFSLINGDDM--------FTTFA----------------------VMQHK--- --------------------------------------------------------SYLV WLFSRVYLYSFISLFIYMVLSLFIALITDTYETIKHYQQD-------------------- ---GFPETELHVFMAQC----KDLPNSGRYKLVD-------------------------- ----------------------------ETPA---------------------------- ----------------LVFCC------------------CKRS----------------- -------------------------------------------TGSKDHG-LK------- ------------------------------C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015204501.1_LG6_Vertebrata_MCOLN1_MCOLN1 ------------------------------------------------------------ ----------------------------------MASAGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------KNC-------- ------------------------------------------------------------ ---------------------NPRRGSERD------------------------------ -----------------------------------RLLT--------------------- ------------------------------------------------------------ ---AVTRY-GSQGHSDDSGDSRAT------------------------------------ ------------------------------------------------------------ -----------P-----------------------GSGSLGSEQEEEEALRR-------- ---------------------------KLKYFFMS----------------------PCD KYHAKG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPYKLI-----------------------------------LQLLKI IIVTVQLVFFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVTFK----D------------------------ ------------------------------------------------------------ --------------------ENTMSFKHLFLKD----Y--ADGSE--------------- --------------------DTLAVYTQTDVYEHIHHAIE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYLALPETT-----------------------------------V------- ---GRYAYVF---GEH---------------------VNESAL----------------- -----------------------------YLC--------QQYYKRGRIDPA-------- ----------------------------------------------NDTFNIDPRVVTAS LCLTP-LSPSA-PLSLLD--------------------------------PSLSSPSAPL SSF----------------------------CTPLSLGLRLINVTVQ-----FRLKAINI QTIINNEIPDCYTFTI-------------------------------------------- -------------------------------------TIVY------------------- ----------------------------------DNKAHSGRVKISLNNEATI------- --------------------------KE-------------------------------- ------------------------------------------------------------ ----CRDPSVSGHAE-N-YT----------------------RLAFDVIVVIVCV----- ----LSLLL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CG RSILRGVLLQQEFARFFREQLGRG----------------------------VC------ -----------------------------WEDRLE------FVNGWYILLVISDILIIVG SCI-KIGIESK------------NLSSYDVCGILL------------------------- ---GTSTLLVWVGVIRYL-SFFQKYNILIITLRAAF-PNVIRFCCCAAVIYLGYCFCGWI VLGPYHV-------------------------------------------KF------RT LSMVSECLFSLINGDDM--------FVTFA----------------------EMQDS--- --------------------------------------------------------SLLV WWFSQVYLYTFISLFIYMVLSLFIALITGAYECIKHQTME-------------------- ---TAHITDLQAFIAKC----TDTPGSGKFRGLD-------------------------- ----------------------------TSAC---------------------------- ----------------SIFCC------------------CDR------------------ -------------------------------------------TTTYEDV-L-------- --------------------------------------L--------------------- ------------------------------------------------------VN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015210872.1_LG10_Vertebrata_MCOLN1_MCOLN2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------M------------------------------ -----------------------------------DFFV--------------------- ------------------------------------------------------------ ---RFNET-FDSRGSTV------------------------------------------- ------------------------------------------------------------ --------------------------------------TSQDFSAEEEALRE-------- ---------------------------DLRYYFMS----------------------PCE KYRMRR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KVPWKLG-----------------------------------VQILKI IMVTTQLVLFGLN----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QLVISYK----E------------------------ ------------------------------------------------------------ --------------------ENSMTFKNLFLKG----YTGTDEDD--------------- --------------------YSRAVYSQQDVYDCVFFAID-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYALLKNLS-----------------------------------V------- ---GPVSYAQ---DDS----------------------EVSPL----------------- -----------------------------VIC--------KQHYRRGSVHSS-------- ----------------------------------------------YESNDIDPETETVC LTLD--IKTIE-DK--EW------------------------------KMANASFFNLDF Y--------------------------------------RLVNLRIS-----FRLNGINL QTIRSHELPDCYEFFI-------------------------------------------- -------------------------------------TITF------------------- ----------------------------------DNQGHSGKMKVYFDSEAIS------- --------------------------IA-------------------------------- ------------------------------------------------------------ ----CKNCKNIGTVQKNKRY----------------------LLVFDVFVIVTCL----- ----TSAVL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CT RSIVLAIKLLQRFARFLHVNYKHK----------------------------VC------ -----------------------------EADNQE------FLNIWYVMVIVSDAMAIVG SIL-KMEIQAK------------SLTSYDVCSIFL------------------------- ---GTSTLLVWVGVIRYL-GYFQKYNVLILTMRAAF-PKVLRFCCCAGMIYLGYTFCGWI VLGPYHE-------------------------------------------KF------EG LSRVAECLFSLVNGDDM--------FATFA----------------------QFQEK--- --------------------------------------------------------STLV WLFSRVYLYSFISLFIYMVLSLFIALITDSYETIKNYQEN-------------------- ---GFPMTDLQRFLKRY----RDFPSSESC-KEQ-------------------------- ----------------------------EAKC---------------------------- ----------------SFVCC------------------CNRL----------------- -------------------------------------------E-GDEDV-L-------- --------------------------------------L--------------------- ------------------------------------------------------IS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015210611.1_LG10_Vertebrata_MCOLN1_MCOLN3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MEDV------------------------------ -----------------------------------GLSA--------------------- ------------------------------------------------------------ ---SYSSI-NDQSGNSFWAQNG-------------------------------------- ------------------------------------------------------------ --------------------------------------EEL-DADAVDNFRR-------- ---------------------------KLKYFFMN----------------------PCE KFKARG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPWKLM-----------------------------------LQILKI AIITIQLVSFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVAFK----E------------------------ ------------------------------------------------------------ --------------------ENLMAFKHLFLKG----Y--SDRPD--------------- --------------------ETYAVYTQSEVYDHIYFAVN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYLNLHNLT-----------------------------------V------- ---GNHAYEK---LED----------------------VYTPL----------------- -----------------------------SVC--------QAFYKNGSIYPG-------- ----------------------------------------------NETFDIDPQIETAC IEIYP-LQPLG-IGTL------------------------------------PSAFTLDF K--------------------------------------RLLSVHIN-----FTLKAINL QTVRLHELPDCYDFTV-------------------------------------------- -------------------------------------TITF------------------- ----------------------------------NNKAHSGKIKITLDNDVDI------- --------------------------NE-------------------------------- ------------------------------------------------------------ ----CRGWNITGASPRNIHY----------------------LLAFDSFIILACV----- ----ASFIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CM RSVINGINLQLEYAVFFLTRYNKK----------------------------VP------ -----------------------------WSERME------FVNGWYILIIVSDTLTIIG SIL-KIEIQTK------------NLTSYDICSILL------------------------- ---GTSTMLVWIGVIRYL-GFFQKYNILILTLRAAF-PNVIRFCCCAAMIYLGYCFCGWI VLGPYHN-------------------------------------------KF------RT LNTVTECLFSLINGDDM--------FPTFS----------------------DMQQK--- --------------------------------------------------------SYLV WLFSRVYLYSFISLFIYMVLSLFIALITDTYETIKQHQRD-------------------- ---GFPESKLQEFIAEC----KDLPASGRYRIEE-------------------------- ----------------------------DKLS---------------------------- ----------------CFSSC------------------WSR------------------ --------------------------------------------FDDSEGRL-------- --------------------------------------D--------------------- ------------------------------------------------------C----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007909912.1_NW:006890597.1_Vertebrata_MCOLN1_MCOLN1 ------------------------------------------------------------ ----------------------------------MVE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ELLQERQ------------------------------ -----------------------------------KLLT--------------------- ------------------------------------------------------------ ---SVNSY-GSQCDTD-------------------------------------------- ------------------------------------------------------------ -----------P-----------------------ATPASSSLDLQEEELRR-------- ---------------------------KLKYFFMS----------------------PCD KYRAKS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPYKLV-----------------------------------VQMIKL IAVTAQLILFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVNFA----E------------------------ ------------------------------------------------------------ --------------------ENTQTFKHLFLKD----Y--ADGSD--------------- --------------------ETHAVYTQDDVYSSLFYIIE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QFLALQNMT-----------------------------------L------- ---GTYAYVI----EN---------------------ENHTAL----------------- -----------------------------ELC--------QQFYKKGQINPA-------- ----------------------------------------------NDTFNINPLVQTEC IGVSP-STLTH-PTEVR----------------------------------MYRNFTLKF Y--------------------------------------KLINVSIR-----FKLKAINI QTIINHEIPDCYTFKI-------------------------------------------- -------------------------------------QILF------------------- ----------------------------------DNKAHSGRIKVSLDNDVVI------- --------------------------KE-------------------------------- ------------------------------------------------------------ ----CMDHSVLGYGP-NDYK----------------------LLIFDIFVLGFCA----- ----LSFIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CA RSIIRGVMLQKEFVKFYWLRYGRE----------------------------LP------ -----------------------------WAVRME------FLNGWYILLIISDILTFLG TIM-KIGIEAK------------NFASYDVCSILL------------------------- ---GTSTLLVWVGVIRYL-SFFQKYNILIVTLRAAF-PNVIRFCCCAAVIYLGYCFCGWI VLGPYHN-------------------------------------------KF------RS LSTVSECLFSLINGDDM--------FVTFA----------------------EMRQK--- --------------------------------------------------------STLV WLFSQLYLYTFISLFIYMVLSLFIALITGSYEAIKHHGIS-------------------- ---GLHPTELHEFIAEC----KDAPGSGKFREVE-------------------------- ----------------------------SSMC---------------------------- ----------------SLFCC------------------CNR------------------ -------------------------------------------TTTYEDT-V-------- --------------------------------------F--------------------- ------------------------------------------------------IN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007885392.1_NW:006890060.1_Vertebrata_MCOLN1_MCOLN2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MTSEENNLKA-------- ---------------------------DLRFFFMS----------------------PCE KYRARC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QLPWKLC-----------------------------------LQLLKI VLVTTQLVLFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------HLVASFK----E------------------------ ------------------------------------------------------------ --------------------ENSLAFKHLFLKG----FQGAREDG--------------- --------------------NSFAVYNRQDVYDSMFYAIN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYLQLHNVT-----------------------------------V------- ---GNYGYVQ---DEN----------------------NLTAL----------------- -----------------------------TVC--------KQLYVKSPPVPSE------- --------------------------------------------NVNRSI-IDSRIETDC LNIEP-FIATN-KVSEKW------------------------------EMSNSSFFILEF Y--------------------------------------RLVQIEIS-----FRLKGIDL QAFQYNELPDCYEFLI-------------------------------------------- -------------------------------------TITF------------------- ----------------------------------DNTVHSGIIKIFLDSDAAI------- --------------------------QE-------------------------------- ------------------------------------------------------------ ----CNDWDISDSLSKSSHY----------------------ILIFDVFIMLICL----- ----MSLIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CT RSIILAISLQKRFASFFLRKYNFN----------------------------VC------ -----------------------------LSDRLE------FLNGWYIMIIISDTMTITG SIM-KMEITVK------------NLTTYDICSILL------------------------- ---GTSTLFVWVGVIRYL-GYFQKYNVLILTMGVAF-PKVLRFCCCAGIIYLGYTFCGWI VLGPYHA-------------------------------------------KF------EN LSTVAECLFSLVNGDDM--------FATFA----------------------ELQEK--- --------------------------------------------------------SNLL WLFSRLYLYSFISLFIYMILSLFIALIQDTYETIKKYQEH-------------------- ---GFPQTDLYTFLNDS----TEIPNISRR------------------------------ ------------------------------------------------------------ ------------------WC---------------------------------------- ----------------------------------------------DDDR-L-------- --------------------------------------L--------------------- ------------------------------------------------------I----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007885391.1_NW:006890060.1_Vertebrata_MCOLN1_MCOLN3 -------------------------------------------------------MGTA- --------------------ERDTGPSECEMQLLFVRSSA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SDK-------- ------------------------------------------------------------ -----------------------TQEMENP------------------------------ -----------------------------------ELII--------------------- ------------------------------------------------------------ ---NS--T-PEEVKSSLFKKDD-------------------------------------- ------------------------------------------------------------ --------------------------------------SFLYDPSFEDQLRR-------- ---------------------------KLKXFFMN----------------------PCE KFQARG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RKPWKLG-----------------------------------VQILKI AMVTLQLVLFGLS----------------------------------------------- --------------------------N--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QMVVLFK----Q------------------------ ------------------------------------------------------------ --------------------ENTIAFKHLFLKD----Y--VDKSDG-------------- ------------------ANNDCVVYTQHDVYEYLSFVIS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------QYIQLHNIS-----------------------------------V------- ---GNHAYER---RGS----------------------HVAPL----------------- -----------------------------TVC--------QYFYKRGSVSPG-------- ----------------------------------------------NETFNVDPKIETDC FNIVP-LVPMH-NGSL----------------------------------NDELNLTLDF H--------------------------------------RLLMVQVG-----FKLKTINL QTIRRHELPDCYYFSI-------------------------------------------- -------------------------------------MITF------------------- ----------------------------------DNKAHSGRIEINLDNDVSI------- --------------------------RE-------------------------------- ------------------------------------------------------------ ----CRGWHIAGAAQRKTNF----------------------KMTFDAFIILVCL----- ----TSLIL--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------CT RSVIKGIKLQQEFAYFFNLRYNKN----------------------------VT------ -----------------------------WSERME------FVNGWYILIIVSDSLTITG SVL-KIEIDAK------------SLASYDVCSILL------------------------- ---GTSTLLVWVGVIRYL-GFFEKYNVLILTLRAAF-PNVIRFCCCAAMIYLGYCFCGWI VLGPYHE-------------------------------------------KF------RS LNVVSECLFSLINGDDM--------FATFA----------------------AMQEK--- --------------------------------------------------------NYIV WLFSRIYLSTFISLFIYMVLSLFIALITDAYETIKLYQKE-------------------- ---GFPQSDLHNFMAEC----KDLPDSGRFRLEE-------------------------- ----------------------------EMPT---------------------------- ----------------SLYCC------------------CNG------------------ --------------------------------------------FNKMES-G-------- --------------------------------------P--------------------- ------------------------------------------------------CN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Human_Homo:sapiens_ENSG00000118762_Chr4_Vertebrata_PKD2 ------------------------------------------------------------ ---------------------------------MVNSSRVQPQQPG-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DAKRPPAP---------------------------- ---------------------------------------RAPDPGRLMAGCAAVGASLA- -A----PGGLCEQRGLEIEM-----------------------------QR-----I--- ------------------------------------------------------------ ---------------RQAAARDPPAGAAASPSPP--------------------LSSCSR QAW--------------------------------------------------------- SRDNPG------------------------------------------------------ ------------------------------------------------------------ --------------FEAEEE---------------------------------------- ----------E---------------------------EEVEGEEGGMVVEM-------- ---------------------------DVEW----------------------------- ----RP-GS---RRSAASSAVS---------------------------SVG-------- ----ARSRGLGGY-------------------------HGAGH----------------- ---------PSGRRRRREDQ--------G------------------------------- ---------PPCPSPVG------------------------------------------- ---GGDPLHRHLPLEGQP---------------------------PRVAWAERLVRGLR- ---GLWGT---------------------------------------------------- ------RLM-EESSTNREKYLKSVLRELVTYLLFLIVL--------C------------- ----------------------------------------------ILTYGMMSSNVY-- ----YYTRMMS-------------QLFLDTP-----VS---------------------- ------------------------------------------------------------ --------------------KTEKTNFKTLSS---------------------------- -------------------MEDFWKFTEGSLLDGLYWKMQ-------------------- ------------------------------------------------PSNQTEA----- -----------------------------------------------DN-RSFIFYENLL L----------------------------------------------------------- --------GVPRIRQLRVRNGSCSIPQD-------------------------------- --------------------------------------LRDEI----------------- -----------------------------KEC--------YDVYSVSSEDRAPFGPRNGT AWIYTSEKDLNGSSHWGIIATYS-----G---------AGYYLDLSRTREETAAQVASL- ------------KKNV--------------------------------WLDRGTRATFID ----------------------------FSVYNANINLFCVVRLLVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----VIPSWQFQPLKLIRYV---------------------TTFDFFLAACEIIF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CF FIFYYVVEEILEIRI--------------------------------------------- ------------------------------HKLHY------FRSFWNCLDVVIVVLSVVA IGI-NIYRTSNVEVLLQ---F-LEDQNTFPNFEHL------------AYWQIQFNNIA-- ---AVTVFFVWIKLFKFI-NFNRTMSQLSTTMSRCA-KDLFGFAIMFFIIFLAYAQLAYL VFGTQVD-------------------------------------------DF------ST FQECIFTQFRIILGD-----------INFA----------------------EIE----- ---------------------------------------------------------EAN RVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQ---------------QK--- --AEMELSDLIRKGYHK----ALVKLKLKKNTVD----DISES----------------- ---LRQGGGKL-------------------------------NFDELRQD---------- --------------------------------------------------LKGKGHTDAE I----------------------------------------------EAI-F-------- -------------------------------TKYDQDG--DQELTEHEHQQ-MRDD---- ------------------------LEKEREDLDLDHSSLP---RPMSSRSFPRSLDDSEE DDDEDSGHSSRRRGSISSG--VSYEEFQVLVRRVDRMEHSIGSIV--------------- -----------------------------------SKI---------DAVIVKLEIMERA K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LKRREVLGRL ----------------------------------------------LDG-VAE--DERLG RDSEIHRE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QMERLVREEL------------------- ----------ERWESDD-AASQISHGLG----------------------TPVGLNGQ-P RPRS-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------SR PSSSQSTEGMEGA----------------------------------------------- -G-----GNGSSNV---------------------------------------------- ------------------------------------------------------------ ----------------------------------HV------------------------ ----- >Human_Homo:sapiens_ENSG00000107593_Chr10_Vertebrata_PKD2L1 ------------------------------------------------------------ ----------------------------------MNAVGSP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EGQ-------------- ------------------EL---------------------------------------- ------------------------------------------------------------ ------------------------QKL-G------------------------------S GAW--------------------------------------------------------- --DNPA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -YSGPPSPHGTLRVCTI------------------------------------------- ------------------------------------------------------------ ----------SSTGPLQ------------------------------------------- ------------PQPK-------------------------------------------- ----------KPEDEPQE----------------------TAYRTQVSSCCLHICQGIR- ---GLWGTT--------------------------------------------------- --------LTENTAENRELYIKTTLRELLVYIVFLVDI--------C------------- ----------------------------------------------LLTYGMTSSSAY-- ----YYTKVMS-------------ELFLHTP----------------------------- ------------------------------------------------------------ --------------------SDTGVSFQAISS---------------------------- -------------------MADFWDFAQGPLLDSLYWTKW-------------------- ------------------------------------------------YNNQSLG----- -----------------------------------------------HGSHSFIYYENML L----------------------------------------------------------- --------GVPRLRQLKVRNDSCVVHED-------------------------------- --------------------------------------FREDI----------------- -----------------------------LSC--------YDVYSPDKEEQLPFGPFNGT AWTYHSQDELGGFSHWGRLTSYS-----G---------GGYYLDLPGSRQGSAEALRAL- ------------QEGL--------------------------------WLDRGTRVVFID ----------------------------FSVYNANINLFCVLRLVVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----AIPSWQIRTVKLIRYV---------------------SNWDFFIVGCEVIF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CV FIFYYVVEEILELHI--------------------------------------------- ------------------------------HRLRY------LSSIWNILDLVVILLSIVA VGF-HIFRTLEVNRLMG---KLLQQPNTYADFEFL------------AFWQTQYNNMN-- ---AVNLFFAWIKIFKYI-SFNKTMTQLSSTLARCA-KDILGFAVMFFIVFFAYAQLGYL LFGTQVE-------------------------------------------NF------ST FIKCIFTQFRIILGD-----------FDYN----------------------AID----- ---------------------------------------------------------NAN RILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAG---------------QK--- --DELQLSDLLKQGYNK----TLLRLRLRKERVS----DVQKV----------------- ---LQGGEQEI-------------------------------QFEDFTNT---------- --------------------------------------------------LRELGHAEHE IT-------------------------------------------ELTAT-F-------- -------------------------------TKFDRDG--NRILDEKEQEK-MRQD---- ------------------------LEEERVALNTEIEKLG---RS-----------IVSS PQGKSGPEA------ARAGGWVSGEEFYMLTRRVLQLETVLEGVV--------------- -----------------------------------SQI---------DAVGSKLKMLERK GW---------------------------------------------------------- ---------------LA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PSPGVKEQAIWKHP ----QPAPAVT-----PDPW-------------------------GVQG-GQE--SEVPY KREEEAL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------EERRLSRGEI------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PTLQRS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Human_Homo:sapiens_ENSG00000078795_Chr5_Vertebrata_PKD2L2 ------------------------------------------------------------ ----------------------------------MAEASR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --W--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -HRG---GASKHKLHYR------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KEVEITTTLQELLLYFIFLINL--------C------------- ----------------------------------------------ILTFGMVNPHMY-- ----YLNKVMS-------------SLFLDTS-----VP---------------------- ------------------------------------------------------------ --------------------GEERTNFKSIRS---------------------------- -------------------ITDFWKFMEGPLLEGLYWDSW-------------------- ------------------------------------------------YNNQQLYNL--- -----------------------------------------------KN-SSRIYYENIL L----------------------------------------------------------- --------GVPRVRQLKVRNNTCKVYSS-------------------------------- --------------------------------------FQSLM----------------- -----------------------------SEC--------YGKYTSANEDLSNFGLQINT EWRY-STSNTNSPWHWGFLGVYR-----N---------GGYIFTLSKSKSETKNKFIDL- ------------RLNS--------------------------------WITRGTRVIFID ----------------------------FSLYNANVNLFCIIRLVAE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----ILTSWQFYSVKLLRYV---------------------SYYDYFIASCEITF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CI FLFVFTTQEVKKIKE--------------------------------------------- ------------------------------FKSAY------FKSIWNWLELLLLLLCFVA VSF-NTYYNVQIFLLLG---QLLKSTEKYSDFYFL------------ACWHIYYNNII-- ---AITIFFAWIKIFKFI-SFNKTMSQLSSTLSRCV-KDIVGFAIMFFIIFFAYAQLGFL VFGSQVD-------------------------------------------DF------ST FQNSIFAQFRIVLGD-----------FNFA----------------------GIQ----- ---------------------------------------------------------QAN PILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSI--------------GRR--- --LDFELGKMIKQSYKN----VLEKFRLKKAQKD----EDKKT----------------- -----KGSGD------------------------------------LAEQ---------- --------------------------------------------------ARREGFDENE I----------------------------------------------------------- -------------------------------------Q--NAEQMKKWKER--------- ------------------------LEKKYY-----------------------SMEIQDD YQP------------------VTQEEFRELFLYAVELEKELHYIN--------------- -----------------------------------LKL---------NQVVRKVSAL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006007388.1_NW:005820519.1_Vertebrata_PKD2_PKD2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------M-----------------------------ER-----V--- ------------------------------------------------------------ ---------------RSQDRRS--AGSTATHSPH---------------------STCSR QAW--------------------------------------------------------- SRDNPG------------------------------------------------------ ------------------------------------------------------------ --------------FEPEEE---------------------------------------- ------------------------------------------------MVEM-------- ---------------------------DMDW----------------------------- ----HP-PASPGRRSVSTASSS---------------------------S---------- -----RS----------------------------------------------------- ----------NNNNRRRRAR--------G------------------------------- ----------LCSTPV-------------------------------------------- ----VDLQHLNQVSHDQ-------------------------------GWGKKILKTVR- ---GLWGT---------------------------------------------------- ------TLM-EGGTTSREKYLKNVLREMITYIIFLVIL--------C------------- ----------------------------------------------LLTYGMVSSNMY-- ----YYTKVMS-------------RLFLETP-----IS---------------------- ------------------------------------------------------------ --------------------EGEQTNFRTLSS---------------------------- -------------------MEDFWKFTEGPYLNGLYWDLW-------------------- ------------------------------------------------YNNETLT----- -----------------------------------------------EN-KSFIYCENLL L----------------------------------------------------------- --------GVPRIRQVKVRNGTCEIHED-------------------------------- --------------------------------------LKDEI----------------- -----------------------------KDC--------YDVYSVGNEDTSQFGLMNGT AWTYTKESDLNGSTHWGLISTYS-----G---------GGYYLDLSKTRVESAAQIKTL- ------------KDRL--------------------------------WLDRGTRAVFFD ----------------------------FSVYNANINLFCIVRLLVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----MVTSWSFQTVKLIRYV---------------------SAFDYFLAACEVAF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CF FVLYYIVEEVLELRI--------------------------------------------- ------------------------------QRLHY------FRSFWNCLDILIIVLSVVA IGI-NIYRTASVDASLG---YLLENQKTFPNFEPL------------AYWQIQFNNMA-- ---AVIVFFAWVKLFKFV-NFNKTMSQLSSTMSRCA-KDVIGFAIMFFIIFLAYAQLAYL VFGTQVD-------------------------------------------DF------ST FQDCIFTQFRIILGD-----------FSFT----------------------EIE----- ---------------------------------------------------------EAN RVLGPIYFTTFVFFIFFILLNMFLAIINDTYSEVKADMAQ---------------QK--- --TEMELADLIKKGCNK----AMVQLRLKKTTVD----DITDS----------------- ---LRQAGGKL-------------------------------NFDELRAD---------- --------------------------------------------------LKGKGHTDAE I----------------------------------------------EAI-F-------- -------------------------------AKYDQDG--DQELTEREHQQ-MRDD---- ------------------------LEKERDDLDLDRSSLP---RPASGRSFPRSLDDSEE EDDEDSGHSSRRRGSSSSG--VSYEEFQVLVRRVDRMEHSIGSIV--------------- -----------------------------------SKI---------DAVIVKLEAMERA K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LKRRDVLGRL ----------------------------------------------LDG-VTE--DERLG RDNEIHRE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QMERLVREEL------------------- ----------ERWESDD-TVSQLSHRLG----------------------TPIGMNGQ-P RSRS-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------SR PSSSQSAEGMDG------------------------------------------------ -G-----GNGASHV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014341843.1_NW:005819135.1_Vertebrata_PKD2_PKD2L1 ------------------------------------------------------------ ----------------------------------MMSI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FTFPLDDVHLQIPTHM------------LLYMVDQGLGHSLPVWVPSLYCF L----------------VEMTL--------------RC-----------QE--------- ------------------------------------------------------------ ----------VRPVTESVDKRITTQGLLS------------------------------N LCWCV------------------------------YIIE--------HAA---------- DRENLG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QFPRVQRWD---------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSRVGETSE- ---GLWGTT--------------------------------------------------- --------LTENTSENRELYVRTTLRELLVYIVFLVDI--------S------------- ----------------------------------------------LLTYGMTSANSY-- ----YYTKVMS-------------DLFLNTP----------------------------- ------------------------------------------------------------ --------------------GDSGVTFKTISS---------------------------- -------------------MTDFWTYAQGPLLDGLYWTKW-------------------- ------------------------------------------------YNNDSLM----- -----------------------------------------------YSPHSFIYYENLL L----------------------------------------------------------- --------GVPRIRQVKVQNNSCTVHQD-------------------------------- --------------------------------------FKHDI----------------- -----------------------------FGC--------YDVYREDKEDKSEVGNINGT AWKYHFEKELGGSTHWGKLATYS-----G---------GGFYQDLKLTKEESASILQEL- ------------KDNL--------------------------------WLDRGTRAVFID ----------------------------FSVYNANINLFCVIRLLVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----AFTSWQIRTVKLIRYI---------------------NNWDYFIIACEIIF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CV FIFYYIVEEILELRI--------------------------------------------- ------------------------------HKLKY------FKSIWNILDVVVILLALVA IIF-HIFRTIKVNILLG---QLLQEPTIYADFEFL------------AFWQTQYNNMN-- ---AVNLFFAWIKVFKYI-SFNKTMTQLSSTLARCA-KDIFGFAIMFFIVFFAYAQLGYL LFGTQVE-------------------------------------------NF------ST FVKCIFTQFRIILGD-----------FDYD----------------------AID----- ---------------------------------------------------------DAN RVLGPIYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELSN---------------QK--- --NELQLSDIIKQSYNR----TLMRLKLKKERIS----DVQKA----------------- ---LQSGSKEL-------------------------------EFEDFRNC---------- --------------------------------------------------LKEMGHTDHE I----------------------------------------------TAA-F-------- -------------------------------TRFDHDG--NHVLDEDEQKI-MQND---- ------------------------LEEKRVALNAEIQNLG---RTYGTNNFDHTVEFVEV KNVQTNSKA--------SG--VSLEEFQMLVQHVVQLEHIIGSIV--------------- -----------------------------------SKI---------DTVMMKLDTLEKS K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VKRKDLMGKL ----------------------------------------------LDN-ITE--NEKIS RDEHLHH----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------NLDRSLKEEM------------------- ----------ESCEVKS-VLGNCSSNIPLG--------------------NRRNFYSSAS RPGSSEL----------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AP PRINTRPQSNTHF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:005989417.1_NW:005819051.1_Vertebrata_PKD2_PKD2L2 ------------------------------------------------------------ ----------------------------------MSQATPA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------QGH-------------- -------------------------------------------------AR--------- ------------------------------------------------------------ -------------------------------------------------------GTGFG FGW--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -IRGRS-GVPQLRVDARAKRFKKDSV---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------VWLYGV SLRRQQVT---------------------------------------------------- ---GVWNAI--------------------------------------------------- ------------TSSSKESKLKTTLQELLIYLIFLIDL--------C------------- ----------------------------------------------ILAFGMVSTEMY-- ----YLNQAMS-------------NLFLESE-----FS---------------------- ------------------------------------------------------------ --------------------ETELTTFKMINS---------------------------- -------------------MEDFWKFAEGPLLEGLYWNKW-------------------- ------------------------------------------------YDKMPAY----- -----------------------------------------------EN-ESYIYYENIL L----------------------------------------------------------- --------GVPRIRQLKVQSGNCYVHGY-------------------------------- --------------------------------------FLKMI----------------- -----------------------------REC--------YGVYSSRYEDRSSFGLMNGT AWTY-SFPSTYTAPHWGYFGYYS-----S---------GGYYLDLAKTKNESAEKIAFL- ------------KSNH--------------------------------WFDHRTRAVFID ----------------------------FTTYNANVNLFCVIRLTVE------------- ------------------------------------------------------------ ----------------------FPPTG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----AVPSWHLYSVKLLRYF---------------------SMYDYFVASCEIIF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CL FTFAFLGQEFIEIWE--------------------------------------------- ------------------------------SKTTY------FKNTWNCVDVLLGLLSLVA IAF-NIFRTTRVSMVLH---KLIKLPDDYADFYFL------------AYWQTQYNNMI-- ---AVIVFIAWIKIFKFI-NFNKTMTQLASTLSRCA-KDIIGFAIMFFIIFFSYAQLGYL VFGTQVD-------------------------------------------DF------ST FENCIFTQFRIILGD-----------FDFA----------------------TIE----- ---------------------------------------------------------MAN RVLGPIYFITFVFFVFFILLNMFLAIINETYAEVKADLSM---------------QN--- --PEFEISDLIRKSYNK----ALVKLKLKKAAVN----EFAEC----------------- ---VRKASGEM-------------------------------NLEKLQQD---------- --------------------------------------------------MEKRGYSEKE TKAI-----------------------------------------------F-------- -------------------------------NAYDIDK--NEELHKTEGQK--------- ------------------------IDQKSQEQQGPVSENKHVKRRGKRKSSRGSLEGTDP EQTN----------------YITKQEYEILVTQVSQLKQQINDMM--------------- -----------------------------------QKM---------DEKTPKSSSEKSG KK---------------------------------------------------------- ---------------AY------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------KSAHN-ETE--DETT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006630139.1_LG4_Vertebrata_PKD2_PKD2 ------------------------------------------------------------ ----------------------------------MSSSRVRPQQ---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RQSQAGRF------------- ------AGSAAGSSGEGIEM-----------------------------ER-----I--- ------------------------------------------------------------ ----------HHHDLGLGGSVGTPSPSSSSSSSS--------------------SSSCSR QAW--------------------------------------------------------- SRDNPG------------------------------------------------------ ------------------------------------------------------------ --------------FEPEEE---------------------------------------- ------------------------------------------------MLEA-------- ---------------------------D--W----------------------------- -----P-PAGPGRRSVSATSSG---------------------------S---------- -----SSSGLGSY-------------------------NGGGGGG--------------- ------GGGGGGGHRMQR----------G------------------------------- ----------LYPTPT-------------------------------------------- ----VEVLQ----HQDRS---------------------------GPRGCGKRILEKIR- ---ILWGT---------------------------------------------------- ------RLM-VDSNTSREKYLKSVLRELVTYVMFLVIL--------C------------- ----------------------------------------------ILTYGMLTSSLY-- ----YYTKAMS-------------QLFLDTP-----VS---------------------- ------------------------------------------------------------ --------------------NTEKTNFRSLAS---------------------------- -------------------MDDFWKFAEGPLLDGLYWDVW-------------------- ------------------------------------------------YNNRTLP----- -----------------------------------------------EN-RSWIYHESLL L----------------------------------------------------------- --------GAPRLRQLKVRNESCVVHED-------------------------------- --------------------------------------LRDTV----------------- -----------------------------QDC--------YGAYSPGHEDTSPFGLLNGT AWIYTNEADLNGSSYWGLIATYS-----G---------GGYYLDLSRTRAETAAQIQTL- ------------KGNL--------------------------------WLDRGSRAVFID ----------------------------FSVYNANVNLFCIVRLVVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----AVTSWQLQTVKLNRYV---------------------SNVDYAIAACEIAF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CL FVLYYVVEEALEVRI--------------------------------------------- ------------------------------HKLYY------FRNLWNCLDILIIALSVAA IVI-NIYRTVTVNSLLK---KLLEIQDAYPNFQPL------------AYMQVQFNNMV-- ---AMIVFFSWIKLFKFI-NFNKTMSQLSSTMSRCA-KDIIGFAIMFLIIFLAYAQLAYL VFGTQVN-------------------------------------------DF------ST FQACIFTQFRIILGD-----------FNFA----------------------EIE----- ---------------------------------------------------------EAN RILGPIYFTTFVFFIFFILLNMFLAIINDTYSEVKADLAQ---------------QK--- --SEMELADLIKKGYNK----ALVKLRLKKTTVD----DISES----------------- ---LRQAGGKL-------------------------------NFDELRQD---------- --------------------------------------------------LKGKGHTDAE I----------------------------------------------EAI-F-------- -------------------------------AKYDQDG--DHELTEHEHQQ-MRDD---- ------------------------LEKEREDLDLDRSSFT---RPASGRSFPRSLDDSEE DDDEDSGHSSRRRGSSSGG--VSYEEFQVLVRRVDRMEHSIGSIV--------------- -----------------------------------SKI---------DAVIVKLEAMERA K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LKRREVLGRL ----------------------------------------------LDG-VIE--DERLG RDGDAHRE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QMERLVREEL------------------- ----------ERWECDD-AGSRASHRLG----------------------TPLGRGRRGP RRRAP------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VRGAP PLQSRTAR---------------------------------------------------- -----------CDV---------------------------------------------- ------------------------------------------------------------ ----------------------------------YL------------------------ ---K- >Lepisosteus:oculatus_Spotted:gar_XP:015203008.1_LG5_Vertebrata_PKD2_PKD2L1 ------------------------------------------------------------ ----------------------------------MSASGLNNR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AKSHFSLQEEH------------------------------------------ ------------------EL---------------------------------------- ------------------------------------------------------------ ------------------------EGM-E------------------------------K GAW--------------------------------------------------------- --VNPA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -YNASP-PMSPLNISTVYNPKP-------------------------------------- ------------------------------------------------------------ -------TLENPYGNISKLD---------------------------------------- -----------VPSPYC------------------------------------------- ----ADIRALEPSGEKKK----------------------S------PGCCFFLAKGIR- ---GLWGTT--------------------------------------------------- --------LTENTSENQELYLRTTLRELLVYILFLIDI--------C------------- ----------------------------------------------LLTYGMTSSSAY-- ----YYTTVMT-------------DLFVNTP----------------------------- ------------------------------------------------------------ --------------------SDNGVTFQSIGD---------------------------- -------------------MADFWSFAQGPLLDGLYWSKW-------------------- ------------------------------------------------YNNQSLS----- -----------------------------------------------NGPHSFIYYENML L----------------------------------------------------------- --------GVPRVRQIKVQNNSCKVHRD-------------------------------- --------------------------------------FRADI----------------- -----------------------------LGC--------YDVYDPQKEDTVAFGLINGT AWQYHTEDQMNGSSQWGLLATYT-----G---------GGYYQDLKMTRDESADILMTL- ------------KNNL--------------------------------WLDRGTRAVFVD ----------------------------FSAYNANINLFSVISLLVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----AIPSYQIRTVKLIRYI---------------------NNWDYFIAGCEIVF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CV FIFYYVVEEILELRI--------------------------------------------- ------------------------------HKLSY------FTSIWNILDVVVILLAIIA IIF-NAFRTIKVNSLLG---KLLEQPDIYADFEFL------------AFWQTQYNNMN-- ---AVNLFFAWIKIFKYI-SFNKTMTQLSSTLARCA-KDILGFAIMFFIVFFAYAQLGYL LFGTEVQ-------------------------------------------TF------ST FVKCIFTQFRIILGD-----------FDYD----------------------AID----- ---------------------------------------------------------QAN RILGPIYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELSK---------------QK--- --DELQLTDFLKQGYVR----TLMKLKLKKEKIS----DVQKA----------------- ---LQSGSKEL-------------------------------VFEDFRNS---------- --------------------------------------------------LKEMGHADQE I----------------------------------------------TAA-F-------- -------------------------------TKFDHDG--NQILDEEEQNR-MKRE---- ------------------------LEEKRVALNAEIEHLG---RNYGNNTLHQSADIVDV KNSNIN-KA--------AG--VSHDEFQMLLRRVLQLEHSVGSIV--------------- -----------------------------------SKI---------DAITVKLENLDRT R----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MKRKDVTGTP ----------------------------------------------LEN-ISE--VE--- ----MAR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------NLDGLVNDQI------------------- ----------NTWATAA-SQGKALGGTTHE--------------------TKSNLYPRIG WPGTLDS----------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AL PPMKTSNHS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015205285.1_LG6_Vertebrata_PKD2_PKD2L2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------M-----------------CA--------D-RH--------- -------------------------------RVL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CNP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FHIKQKDE- ---SNTST---------------------------------------------------- ------ELTDEPDFRSRDLRIKTTLRELLIYAVFLINL--------C------------- ----------------------------------------------ILTFGQVSTDMY-- ----FHTKVMS-------------RLFLESF-----IS---------------------- ------------------------------------------------------------ --------------------GGD-ITFRSLRT---------------------------- -------------------VDDIWKYLEGPLLENLYWNDR-------------------- ------------------------------------------------FPKKSLD----- -----------------------------------------------EN-ESFIYFENVL L----------------------------------------------------------- --------GVPRIRQVKVTNTSCSVHGS-------------------------------- --------------------------------------FAFEM----------------- ------------------------------EC--------YDAYLTLKEDTASFGPMNST AWIYSPPSS-VVDIHWGWVSTYS-----G---------GGFYLDLEKAKEKNADKIRTL- ------------RSNR--------------------------------WLTRGSRAVFID ----------------------------FSVYNSNINLFCVVRLVAE------------- ------------------------------------------------------------ ----------------------LPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----VLTSWQFYSVKLLRYV---------------------SSVDYVLALCEVVF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CL FIIAFGFQECVELYQ--------------------------------------------- ------------------------------KRCSY------FIEFWNCLELILIVMSVVA ISF-NVYRTSEVHTLLE---SLQENPQKYPDFHFL------------AFWQTQYNNMI-- ---AVNVFICWVKVFKYI-NFNKTMNTLTSTLSHCA-KDVIGFAVMFFIIFFAYAQLAYL LFGSQVE-------------------------------------------NF------ST FKNCVFTQFRIILGD-----------INFN----------------------EIE----- ---------------------------------------------------------HSN RILGPIYFTTFVFFVFFILLNMFLAIINDTYSEVKLDQSI---------------QN--- --AEFEVTDFIKKACGK----ALVKLNFRKKLQG----RTTDC----------------- ---NHEAGEGI-------------------------------TLNTVQIG---------- --------------------------------------------------------TTNQ V--------------------------------------------ETEEH-F-------- -------------------------------TAFGTES--NTDITREEREE-EQIMGWD- ------------------------LERQKERVLNSTH-----------------LDKGEE FMSL----------------YVPRQEYQQLAEHVSLLQKRIDALT--------------- -----------------------------------FMN---------NRILVRLNSFEGI NK---------------------------------------------------------- ---------------LA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TE--DN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WDTDV-EDCS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007890233.1_NW:006890074.1_Vertebrata_PKD2_PKD2 ------------------------------------------------------------ ----------------------------------MMSSRVRPQPP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PPL----------------------------- -------------------------------------------PGRLTPAASRL------ ------QGQQQQQQEEQLEM-----------------------------GK-----VRGS ------------------------------------------------------------ --------GDGRHQARGAGRRARGSGASSSSTSS---------------------AASSR QAW--------------------------------------------------------- SRANPG------------------------------------------------------ ------------------------------------------------------------ --------------YEPGDE---------------------------------------- ------------------------------------------------ELDM-------- ---------------------------ELEWAEAA------------------------- --GAAP-PSSPGRRSASSAGSG---------------------------TSG-------- -----GSGGAPGY-------------------------NPRG------------------ ----------NGRNR-------------G------------------------------- ----------PCPTPT-------------------------------------------- -------------RELQA---------------------------RRPGCAGKVLQKIR- ---ALWGT---------------------------------------------------- ------RLT-ESQATTREKYLKNVLRELVTYIIFMVIL--------C------------- ----------------------------------------------ILTYGMVSSTMY-- ----YYTKVMS-------------DLFLDTP-----FA---------------------- ------------------------------------------------------------ --------------------ANEKANFRSLSS---------------------------- -------------------MDDFWKYTDGPLLNGLYWDLW-------------------- ------------------------------------------------YNNETMT----- -----------------------------------------------EN-KSFIYYENLL L----------------------------------------------------------- --------GVPRMRQLKVKNESCKIHED-------------------------------- --------------------------------------LKDEI----------------- -----------------------------KEC--------YDVYSFANEDSAPFGPKDGT AWIYTPEKDLKANRYWGLIATYS-----G---------GGYSLNLGRRRDETAAKFKVL- ------------KENL--------------------------------WLDRGTRVVFID ----------------------------FTVYNANINLFCVIRLVVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----ALSSWQFQTVKLIRYI---------------------SSFDFFLAACEIAF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SI FIFYYIVEEILEIYI--------------------------------------------- ------------------------------HRLHY------FRNLWNCLDIVIIMLSLVA ICI-NIYRMSMVNTLLG---ELLEKQNSYHNFESL------------AYWQIQFNSVA-- ---AVVVFFAWIKIFKFI-SFNKTMIQLSSTMSRCA-KDILGFAIMFFIVFLAYAQLAYL VFGTQVD-------------------------------------------DF------ST FQTCIFTQFRIILGD-----------FDFI----------------------KIE----- ---------------------------------------------------------EAN RILGPIYFATFVFFIFFILLNMFLAIINDTYSEVKADLSH---------------QK--- --NEMELTDLIKKGCSK----ALVKLRLKKTTVD----DITES----------------- ---LRQAGGKL-------------------------------NFDELRQD---------- --------------------------------------------------LKGKGHTDAE I----------------------------------------------EAI-F-------- -------------------------------AKYDRDG--DQELTEHEHQQ-MRDD---- ------------------------LEKERDDLDLDRSSLP---RSTSGRGFPRSLDDSED EDDEDSGHSSRRRGSSSSG--VTYEEFQVLVRRVDRMEHSIGSIV--------------- -----------------------------------SKI---------DAVIVKLEAMERA K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LKRRDVLGRL ----------------------------------------------LDG-VTE--DERSG RDNDIHRE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QMERLVREEL------------------- ----------ERWESDD-TVSQLSQHLG----------------------TPLGMNWQ-S RSCS-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------SR PSSSQSTEGLDA------------------------------------------------ -A-----GHGGSHV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007897917.1_NW:006890056.1_Vertebrata_PKD2_PKD2L1_Partial ------------------------------------------------------------ ----------------------------------MSSFQDN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GFKFTAKEVH------------------------------------------ ------------------EM---------------------------------------- ------------------------------------------------------------ ------------------------ESLTN------------------------------K TAW--------------------------------------------------------- --DNAG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FEGSP-PNSPFKS---------------------------------------------- ------------------------------------------------------------ ---------KSSFTNIK------------------------------------------- ------------------------------------------------------------ --------------------------------------------------CSKTLPCAM- ---GLWSTK--------------------------------------------------- --------LTENTSNNPELYIKTTLRELLVYIVFLVDI--------C------------- ----------------------------------------------LLTYGMTSSNTF-- ----YYTKVMS-------------NLFLSAA----------------------------- ------------------------------------------------------------ --------------------SDTGVSFQTIGS---------------------------- -------------------MADFWSYTQGPLLNGLYWTKW-------------------- ------------------------------------------------YNNDSFS----- -----------------------------------------------RGPHSFIYYENMV L----------------------------------------------------------- --------GVPRIRQIKVMNNSCVVHKD-------------------------------- --------------------------------------FREDI----------------- -----------------------------TGC--------YNVYSLDNENKAPFGLQNGT AWTYSSEEQLGGSSHWGKLTVYS-----G---------GGYYQDLKSNMVESSAILQDL- ------------KDNL--------------------------------WLDRGTRAVFVD ----------------------------LSVYNANINLFCIIRLVVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----AVTSWQFRTVKLIRYV---------------------NNWDYFIIGCEIVF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CV FIFYYIVEEILEIRI--------------------------------------------- ------------------------------HKLQY------IKCIWNCLDLMVILLSLVS IGF-HIFRTIKVNIILG---ALLKYPEAYADFEFL------------AFWQTQYNNMN-- ---AVNLFFAWIKIFKYI-SFNKTMTQLSSTLARCA-KDILGFAIMFFIVFFAYAQLGYL LFGTQVE-------------------------------------------NF------ST FLKCIFTQFRIILGD-----------FNYD----------------------EID----- ---------------------------------------------------------NAN RILGPIYFVTYVFFVFFVLLNMFLAIINDTYSEVKADLSD---------------QK--- --DELQITNFIKQGYNK----ALTKMKRKKERIA----DVQKA----------------- ---LQIGSKEL-------------------------------GFEDFKNN---------- --------------------------------------------------LKGLGHSDQE I----------------------------------------------ADA-F-------- -------------------------------SKYDYDG--NKILDEEEQTR-MKEE---- ------------------------LEEKKVALSVEIENMG---RNFMCPNSTHA--FTQS KDFDDDTKSNKIANKANTG--ISDEEFQSLAHRVIQLEHLIGNTV--------------- -----------------------------------SKI---------DAITIKLEIMERN ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007899556.1_NW:006890140.1_Vertebrata_PKD2_PKD2L2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MVNSNMY-- ----FFTKVMS-------------NLFLETK-----SS---------------------- ------------------------------------------------------------ --------------------AQ-LVNFKKIRS---------------------------- -------------------MEDFWEFAEGPLLDSLYWKEW-------------------- ------------------------------------------------YDGQPLS----- -----------------------------------------------SK-ESYIYYENIL L----------------------------------------------------------- --------GVPQIRQVRVRNNTCSVLKY-------------------------------- --------------------------------------FRDTF----------------- -----------------------------KDC--------FNEYSLANEDHSAFGLQTGS EWEYTVPNSQFELRHWGKISKYR-----N---------GGYILDLDRQKEESAKKIKHL- ------------KSNL--------------------------------WLDLGSRAVFID ----------------------------FSVYNANVNLFCALRLLVE------------- ------------------------------------------------------------ ----------------------FPATG--------------------------------- ------------------------------------------------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----ATTSWHIYTVKLLRYV---------------------STLDYFLGACEILF----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CL FILNYLGQELIEMYE--------------------------------------------- ------------------------------LKLRY------FQSFWNCLDFLIVLLSLLA IVF-SIYRTAKVSLVLE---KLLENSFKYPNLYFL------------AYWQNQYNNMI-- ---AITVFIAWIKIFKFI-SFNETMTQLATTLQHCA-KDIAGFAIMFFIIFFGYAQLGYL IFGAQVE-------------------------------------------SF------HT FSNCIFTQFRIILGD-----------FNFA----------------------EIE----- ---------------------------------------------------------KAN RILGPIYFTTFVFCIFFVLLNVFLAIINETYAEVKGNRSL---------------RK--- --IDFDISDLIKKHIDR----CLIRFKLKK------------------------------ ------------------------------------------------------------ --------------------------------------------------------APTE V---------------------------------------------YEAI-E-------- -------------------------------SKAEKEK--EQSLQDDEKNE-NKESAQAI LND------------P-------CLEELGEEINQEQHT-----------NTYYGIDNGEE YNSYRDHVVDKNNR-------ISARSYHLLIVRTEKLEYQMNCIL--------------- -----------------------------------PKV---------QWIVNLLRKIDHV K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LDK-LTS--KQKLV VEE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KPDL------------------- ----------ETWSQII-TESQ-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E PSPKK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000104321_Chr8_Vertebrata_TRPA1 ------------------------------------------------------------ ----------------------------------MKRSL--------------------- ------------------------------------------------------------ -------------------------------------------RKMWRPGEKKEPQG--- ------------------------------------------------------------ -----------VVYEDVPDDTEDFK----E-------SLKVVFEGSAYGLQNFN------ -------------------------------------------------KQ--------- -KK--LKRC-----------------------DDMDTFFLHYAAAEGQIELMEKITRDSS LEVLHEMDDYGNTPLHCAVEKNQIESVKF------------------------------- ------------------------------------LLS--------------------- RGANPN------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LR------------------------ ------------------------------------------NFNMMAPLHIAV------ ---------------------QGMN-NEVMKVLLEHRT----------------IDVNLE GENGNT----AVIIACT------------------------------------TNNSEAL QILLKKGAKPCKS-------------------------NKWGCFPIHQA----AFSGSKE CMEIIL------------------------------------------------------ -----------------RFGEEHGYSR--------------QLHINFMNNGKATPLHLAV QNGDLEMIKMCLDNGAQI-----DPVEKG---------RCTAIHFAATQGATEIVKLMI- ------------------------------------------------------------ -----SSYSGSVDIVNTTDGCHETMLHRASLF-----------------DHHELADYLIS --------------------------VGADINKID------------------------- ------SEGRS-------------PLILATA----------------------------- ------------------------------------------------------------ --------------------SASWNIVNLLLS------KGAQVDIKDNFG-RNFLHLTVQ QPY------GLKNLR--PEFMQMQQ------IKELVMDED-------------------- -----------------NDGCTPLHYACRQGG------------------PGSVNNLL-- ------------------------------------------------GFNVSIHSKSKD K--------------------------------------------------------KSP LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFL SDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTAL-----------HFAARE GHAKAVALLLSH----------------------------NADIVLNKQQAS-------- ----FLHLALHNKRKEVVLTIIR-SKRW---DECLKI---FSHNSPGNKCPITEMIEYLP ECMKVLLDFCMLHSTEDKSCRDYYIE----------------------YNFKYLQCPLEF TKK------------------------TPTQDVI-YEPLTALNAMVQ-----NNRIELLN HPVCKEYLLMKWL-------------AY-------------------------------- ------GFRAHMMNLGSYCLGLIPMTIL---------VVNI-KPG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MAFNSTGIINETS------DHS-------EILDTTNSYLIKTCMILV----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------FL SSIFGYCKEAGQIFQ--------------------------------------------- ------------------------------QKRNY------FMDISNVLEWIIYTTGIIF VLP---------------------------------LF-VEIP--AHLQWQCG------- ---AIAVYFYWMNFLLYL-QRFENCGIFIVMLEVIL-KTLLRSTVVFIFLLLAFGLSFYI LLNLQDP--------------------------------------------F------SS PLLSIIQTFSMMLGD-----------INYR-------------ESF-------------- ------------LEPYLRNE-------------------------------------LAH PVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHAS--------------------- ----LKRIAMQVELHTSL--EKKLPLWFLRKVDQ-KSTIVYPN----------------- ----------------------------KPRS-------------------GGMLFHI-- --------------------------------------FCFL------------------ ------------------------------------------------------------ -------------------------------------------FCTGEIRQ-EIPNAD-- ----K------------------------------------------------------- ----------------------------SLEMEILKQKYRLKDLT--------------- -----FLLEKQ-----------------------HELI---------KLIIQKMEIISET ED-DDS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HCSFQDRFKKEQ-MEQ------- -------------------------------------------------------RNSR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WNT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VL-------RAVKAKTHHL E----------------------------------------------------------- -----------------------------------P------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014342061.1_NW:005819151.1_Vertebrata_TRPA1_TRPA1 ------------------------------------------------------------ ----------------------------------MKEQDHCS------------------ ------------------------------------------------------------ -------------------------------------------GKMSKGCSLKELKPN-- ------------------------------------------------------------ ------QNSSESFYTSVSKEDETKENVGED-------IFQLISDGNITAVQNII------ -------------------------------------------------MK--------- -NSDCLSKL-----------------------DKLNATPLHYAAGDGNLEIMQMIMDDAE YEVLNVMDCNGNTPLHWATEKNQIESVKM------------------------------- ------------------------------------LLD--------------------- RGANPN------------------------------------------------------ ------------------------------------------------------------ ----------------------------------IL------------------------ ------------------------------------------NSAVESPLHLAI------ ---------------------KLSH-NEMVEVLLSYHN----------------TDVNLG GELENT----PLILACW------------------------------------IDNHGAV RILFDHGALLCKP-------------------------NRFKIYAIHVA----AFAGSKT SMELLL------------------------------------------------------ -----------------TKGEELGYTR--------------EKQINFIDKSLNSPLHLAI HGGNIETIKCCIDNGANL-----ELQENN---------KSMALHLACSQGAIETVKLIL- ------------------------------------------------------------ -----LSYSGKKDLVNIPDGIMQTPLHRAAVF-----------------DHYEVVDYLLS --------------------------KGANIDSVD------------------------- ------CELRS-------------ALLLATS----------------------------- ------------------------------------------------------------ --------------------CGAWKTVNLLVS------KGVNTKLKDKSG-CNFLHLVAL QPR------GLKNLN--EEVLQVQHC--SNCIKELLNDVD-------------------- -----------------NDGCTPLHYACKQGV------------------SDSVNNMI-- ------------------------------------------------GLKVCVLSKTKN K--------------------------------------------------------RSA LHFAAAYGRFHTCRNLLQNMSDTRLLNEGDEKGMTPLHMAAENGHAKVVQLLLKKGALTL CDFKEYTSLHYAALGGYTQTMQVLLDTHLKLMDETEEEGNTAL-----------HLAARE GHTSAVCLLLAK----------------------------GAKITLNKSNAS-------- ----FLHEAVHHGRKDVTHAIIF-SERW---HEAIMS---FDFTSD-NGCSLLDMIAYLP EAYRWVLDRSMNESSEDKRSPNFFIE----------------------YDFRYLQVPLYM KEM------------------------TKENKALHFEPLICMNNMVR-----FKRMELLT HPVCREYLRMKWI-------------AY-------------------------------- ------GIKAHVINLAVYLLGLLPLTAL---------IVYP-REKNNSTE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TFSPKYAQRNGQ-V----PH-----------------FVTVCMFIV----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LF MSLFGVCKELVQLFQ--------------------------------------------- ------------------------------QRWKY------LMDCSNLLDWSIIVFNILF VVP---------------------------------MLFGNFN--G-CHWEFG------- ---SIAVFLSWVNLLLYF-QRFEQCGIYVVMFWEIL-KTLFRIVLLFFFLILAFGLTFYA LMNSQVS--------------------------------------------Y------SS PVFSTIRVFTMMLGE-----------INYQ-------------DSF-------------- ------------LIPLMENK-------------------------------------MAY PGLTFIMLIVFVLLMPILLMNLLIGLAVGDIAEVQRNAS--------------------- ----LKRIAMQIQLHTSL--ENKLPLWFLKRVDQ-LTLKVYPN----------------- ----------------------------RSR----------------------------- --------------------------------------FCGLG----------------- ----VM------------------------------------------YSFF-------- ------------------------------------------FFLNVVQST-SL------ TSDVS------------------------------------------------------- ----------------------------VLELELKKQKYRLKDMS--------------- -----ALLHKQ-----------------------HELI---------KLIIQKMEIVSET ED-QDD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QDLSQYSKAKRHNFAQ------- -------------------------------------------------------KTSK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WDT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VL-------KVIQTKGI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006634049.1_LG9_Vertebrata_TRPA1_TRPA1 ------------------------------------------------------------ ----------------------------------MKKED--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SLYECVVDDDPSQ--LSMD-------VFQLALEGNKSGLEDLI------ -------------------------------------------------NK--------- -NPDCLLTS-----------------------NEARATPLHFAAAGGHHGIIHFIVNMAG PEGLNTVDDLGNTPLHWAVEKKQMESCNA------------------------------- ------------------------------------LLQ--------------------- LGADPN------------------------------------------------------ ------------------------------------------------------------ ----------------------------------IL------------------------ ------------------------------------------NNSLLSPLHLAV------ ---------------------NLWH-NNLVDLLLCHSS----------------TNSNLE GDLGNT----PSMLACS------------------------------------IDNHEAL GILLKHGAKLCRQ-------------------------NKLGHFAVHAA----AFAGAKK SMEIIL------------------------------------------------------ -----------------KKGEEMGHSV--------------FTHINYLDKSSSSPLHLAV HGGNIEVIKLCIDNGAKI-----DLQQCD---------KSTALHFACTQGATEAVKLML- ------------------------------------------------------------ -----SSHDRVEEVVNIIDGAHQTPLHKASIF-----------------DHVDLVEYLLL --------------------------KGAKIESID------------------------- ------CKGHT-------------PLLLATR----------------------------- ------------------------------------------------------------ --------------------CGAWRTVELLLN------KGANVKIRDKQG-CNFVHLAVL QPK------GLKNLP--EKFLQHKD------VKGLLNSED-------------------- -----------------NEGCTPLHYACRLGV------------------SDSVNNML-- ------------------------------------------------GMKVSLNLKSKD K--------------------------------------------------------KSA LHFAAEYGRINTCRRLLETMVDTRLLNEGDEKGLTPLHLASVGGHTKVVDLLLRKGALFL SDHKGWTCLHHAAAEGYTQTMKILLGTNIKLMDKVDEDGNTAL-----------HLAARE GHTGAVKLLLSK----------------------------GAEITLNKSEAS-------- ----FMHEAIYHGRKEVAYAVIE-SERC---TQALIT---FKLGSA-KACPVLDMIEFLP EAFKFLLDKSVNESEDDVNSYDYCIQ----------------------YNFQWLQAPMHY AKL------------------------AKTDKRYYFKPLGALNAMVR-----FNRIELLT HPVCKKYLEMKWL-------------AY-------------------------------- ------GVKVHGLNLAIYTLGLLPLSHL---------IVSM-RPSINETY---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GN--ITVASKPLNKQ---------H----------------FFLTTCMMLV----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------FV MNVYTVGKELVQIFQ--------------------------------------------- ------------------------------QRRRY------FRDFSNFLDWSAALFSILF VVP---------------------------------LM-NDFK--GNWHWQCG------- ---AIAVLLSWVNFLLYL-QRFEWIGIYVVMFGEIL-RTLICIVLLFFFLMLAFALSFYA LMLGQRN--------------------------------------------F------GT IDASLMQTFVMMVGE-----------LSYQ-------------DNF-------------- ------------LIPSLQNK-------------------------------------LPF PHITFVIFIWFTLLMPILLMNLLIGLAVGDIAEVQRNAS--------------------- ----LKRIAMQIDLHTSL--EEKLPYWFMKRVDQ-ETITVYPN----------------- ----------------------------RT------------------------------ ---------------------------------------CAEK----------------- ----VQ-------------------------------------------SLL-------- ------------------------------------------NWSDQAESR-SRLSA--N TCHLT------------------------------------------------------- ----------------------------PLENELQRQKYRLKDIS--------------- -----NVLEKQ-----------------------HNLL---------KLIIQKMEITTEA DE-NDG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PDLFQHGNERKQ--LQ------- -------------------------------------------------------KKSK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WFP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LL-------KAVHSKMQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007885526.1_NW:006890060.1_Vertebrata_TRPA1_TRPA1 ------------------------------------------------------------ ------------------------------MLQILKTGTIC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------NSYSFVEKSQECSQNRS-D-------IFEVIAAGDVKSVERLM------ -------------------------------------------------EK--------- -DHDCLNRL-----------------------DEDKSTPLHHAAGGGHLDILKLIIDDAD FEVLNVIDSNGNTALHWATEKNQVKCVQG------------------------------- ------------------------------------LLD--------------------- RGANPN------------------------------------------------------ ------------------------------------------------------------ ----------------------------------IL------------------------ ------------------------------------------NNALLSPLHVAV------ ---------------------NLHH-SAVLEVLASNKT----------------SDLNLA GELENT----PVMLACS------------------------------------IDNHEGI SILLSHGASLCKQ-------------------------NKLGHSALHQA----AFSGAKK SLELIL------------------------------------------------------ -----------------RKGMDMGYTS--------------EYLLNIPDKTHCSPLHLAL HGGNMETIKICIENGAKL-----DFQQDD---------IPAPLHFACMQGQIKVVKLIL- ------------------------------------------------------------ -----SKFTAANSILNVLDDVKQTPLHKAAMY-----------------DHSHLVEYLIE --------------------------QGAEMNIVD------------------------- ------CETRT-------------PLLWAAS----------------------------- ------------------------------------------------------------ --------------------RGSWKSVKVLLA------RGANVKIKNDAG-CNFFHLTLL QPG------GLKNLG--QEILSCEY------IQELLYDQD-------------------- -----------------IDGCTPLHYACRQGL------------------LDSVDKIM-- ------------------------------------------------NLKMCLHIKTKD K--------------------------------------------------------KTP LHFAAGYGRLKTCQRLLQNLKDTKFLNEGDGKGMTPLLLAAQNGHTKVVQLLLMKGSLLL WDYEGWTSLHFAAAGGYSHTMKILLETNIKLIDQVDLKGNTAL-----------HFAASE GHVNAVRLLMTK----------------------------GAAIKLNENDAS-------- ----FLHEAIHKGRKEVALAIVE-SERF---YEAMCI---FVHGSP-MGCPVLEMIEHLP ESFKGLLDKCMKESSEDKKNINFSIE----------------------YNFKYLQCPINY RKI------------------------IKGDKLITYKPLTTLNAMVK-----YNQTELLN HPVCKTYLQMKWR-------------AY-------------------------------- ------GIMAHVINMLLYSVLLLPMTVL---------ILVA-RPHGVNSQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SHILLNVTQTAIGTQTE-I---EEH----------------TVEKICATIV----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------FI MSGLGICKEIIQLFQ--------------------------------------------- ------------------------------QRWQY------LVDSSNLLDWIIYVMSIVF VTP---------------------------------WV-LDMS--IAWQWQCG------- ---IIAALSSWVNFLLFL-QRFEISGIYVVMFAEIL-NTMFHIIILFFFLILAYGLTFYI LLYEQIA--------------------------------------------Y------ES LPLSLMKTLAMMLGD-----------INYQ-------------ETF-------------- ------------FIPFKEGR-------------------------------------LQF PLLTFIILLIFMLIIPILLMNLLIGLAVGDIASVQRNAK--------------------- ----LKRMTMQIFLHTSL--EKKLPKWFLKIVDQ-QSIKIYPN----------------- ----------------------------KPS----------------------------- ---------------------------------------CFL------------------ ----VG-------------------------------------------NMF-------- ------------------------------------------EYMLPKQSF-DKDSCDDE TIAPA------------------------------------------------------- ----------------------------KLELQLEKQKNLLKDMS--------------- -----EVMQKQ-----------------------HELL---------QLIIQKLEINSET ED-QEA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------IEHLHYSKAKAS-ISQ------- -------------------------------------------------------K---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000144935_Chr3_Vertebrata_TRPC1 ------------------------------------------------------------ ---------------------------------MMAAL---------------------- ------------------------------------------------------------ -----------------------------------------------------YPSTD-- --------------------LSGASSSSLPSSP--------------------------- ---SSSSPNEVMALKDVREV---------------------------------------- --------------KEENTL-----------------------------NE--------- -----------KLF---------------------------------------------- ---------------LLACDKGDYYMVKK------------------------------- ------------------------------------ILE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------E-NSSGDLNI-------- ---------------------------NCVDVL--------------------------- ---GRN----AVTITIE------------------------------------NENLDIL QLLLDYG----------------------------------------------------- ------------------------------------------------------------ --------------------CQSAD-----------------------------ALLVAI DSEVVGAVDILLNHRP-------KRSSRP------------------------------- ------------------------------------------------------------ -----TIVKLME------------------------------------------------ -------------------------------------RIQNPEYST-------------- ------TMDVA-------------PVILAAH----------------------------- ------------------------------------------------------------ --------------------RNNYEILTMLLK------QDVSLPKPH------------- -----------------AVGCECTLCSAKNKKDSLRHSRF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLDIYRCL-------------------------------------------- --------------------------------------ASPAL----------------- -------------------------------------------IMLTEEDP--------- -----ILRAFELSADLKELSLVE-VEFR------------------NDYEELARQCKMFA KDL---LAQAR-NSRE-------------------------------------LEVILNH -TS-----------SDEPLD----KRG----LLEERMNLSRLKLAIK-----YNQKEFVS QSNCQQFLNTVWFGQMSGYRRKP------------------------------------- --------TCKKIMTVLTVGIFWPVLSL-------CYLIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSQFGRIIHTPFMKFI-------IH-------------GASYFTFLLLLNL----- ----YSLVYNE------------------------------------------------- ------------------------------------------------------------ ----------------------------------------DKKNTMGPALERIDYLL-IL WIIGMIWSDIKRLWY--------------------------------------------- -----------------------------EGLEDF------LEESRNQLSFVMNSLYLAT FAL-KVVAHNK-------------------FHDFA----------DRKDWDAFHPTLVAE GLFAFANVLSYLRLFFMY-TTSSILGPLQISMGQML-QDFGKFLGMFLLVLFSFTIGLTQ LY-------------------DKG--YTSKEQ---KDCVGIFCEQQSNDT-FHS--FIGT CFALFWYIFSLA-------------HVAIF--------------------VTRFSYGE-- ---------------------------------------------------------ELQ SFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDK------------EW------ ---KFARAKLWLSYFDD---KCTLPPPF----------NIIPS----------------- ---------------------------------------------------PKTICYMIS SLSKWI---------------------------------CSHT-------SKGKVKRQNS LKEW---------------------------------------RNLKQK----------- -----------------------------RDENYQK--VMCC------------------ ----------------LVHRYLTSMRQKMQSTDQATVEN---------------LN---- ----------------------------ELRQDLSKFRNEIRDLL--------------- ----------------------------------------------------GFRTS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYAMFYP RN---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000138741_Chr4_Vertebrata_TRPC3 ------------------------------------------------------------ ----------------------------------MSTKVRKCK----------------- --------------------------EQARVTFP-------------------------- ---------APEEEEDEGEDEGAE----------------------PQRRRRGWRGVN-- ---------------------GGLEP---RSAPSQREPHGYCPPPFSHGPDLSMEGSPSL --RRMTVMREKGRRQAVRGPAF---------------MF--------------------- -----------NDRGTSLTA-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ESK---TLNV-------- ---------------------------NCVDYM--------------------------- ---GQN----ALQLAVG------------------------------------NEHLEVT ELLLKKEN---------------------------------------------------- ------------------------------------------------------------ -------------------LARIGD-----------------------------ALLLAI SKGYVRIVEAILNHPGFAAS--KRLTLSP------------------------------- ------------------------------------------------------------ -----CEQELQDD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CQKYEVVHMLLM------KGARIERPH------------- -----------------DYFCKCGDCMEKQRHDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELAKLANIE-KEFK------------------NDYRKLSMQCKDFV VGV---LDLCR-DSEE-------------------------------------VEAILNG -DLE----------SAEPLE----VHR-------HKASLSRVKLAIK-----YEVKKFVA HPNCQQQLLTIWYENLSGLREQT------------------------------------- --------IAIKCLVVLVVALGLPFLAI-------GYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSRLGKILRSPFMKFV-------AH-------------AASFIIFLGLLVFN---- ----ASDRFEG-----------------------------ITTLPNITV-TDYPK----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTQFTWTEMLI-MV WVLGMMWSECKELWL--------------------------------------------- -----------------------------EGPREY------ILQLWNVLDFGMLSIFIAA FTA-RFLAFLQATKAQQ--YVDSYVQESDLSEVTLPPEIQYFT-YARDKWLPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFI LYSYYLG------------------------------------AKV-NAA-FTT--VEES FKTLFWSIFGL---------------SEVT--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDV------------EW------ ---KFARSKLWLSYFDD---GKTLPPPF----------SLVPS----------------- ---------------------------------------------------PKSFVYFIM RIVN----FP----------------------------KCRRR----------RLQKDIE MGMG---------------------------------------NSKSRLNLF-------- -----------TQSNSRVFESHSFNSILNQPTRYQQ--IMKR------------------ ----------------LIKRYVLKAQVDKEN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEDK--------------- ----------------------------------------------------SQATEELA -I---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIHKLS- ------------------------------------------------------------ ----------------------------------------------------EKLNPSML RCE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000133107_Chr13_Vertebrata_TRPC4 ------------------------------------------------------------ ----------------------------------MAQF---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKRNV-- ------------------------------------------------------------ ----NAPYRDRIPLRIVRA----------------------------------------- --------------ESELSP-----------------------------SE--------- -----------KAY---------------------------------------------- ---------------LNAVEKGDYASVKK------------------------------- ------------------------------------SLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYFKINI-------- ---------------------------NCIDPL--------------------------- ---GRT----ALLIAIE------------------------------------NENLELI ELLLSFN----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLHAI RKEVVGAVELLLNHK--------KPSGEK------------------------------- ------------------------------------------------------------ -----QVPPIL------------------------------------------------- --------------------------------------LDKQFSEF-------------- ------TPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKLLVQ------KGVSVPRPH------------- -----------------EVRCNCVECVSSSDVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYKAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----FLTAFQLSWELQELSKVE-NEFK------------------SEYEELSRQCKQFA KDL---LDQTR-SSRE-------------------------------------LEIILNY RDD-----------NS-LIE----E--------QSGNDLARLKLAIK-----YRQKEFVA QPNCQQLLASRWYDEFPGWRRRH------------------------------------- --------WAVKMVTCFIIGLLFPVFSV-------CYLIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSPLGLFIRKPFIKFI-------CH-------------TASYLTFLFLLLL----- ----ASQHIDR------------------------------------------------- ------------------------------------------------------------ ----------------------------------------SDLNRQGPPPTIVEWMI-LP WVLGFIWGEIKQMWD--------------------------------------------- -----------------------------GGLQDY------IHDWWNLMDFVMNSLYLAT ISL-KIVAFVK-------------------YSALN----------PRESWDMWHPTLVAE ALFAIANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYY-------------------------EETKGLTCKGIRCEKQ-NNA-FST--LFET LQSLFWSIFGL---------------INLY--------------------VTNVKAQH-- ---------------------------------------------------------EFT EFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI------------EW------ ---KFARTKLWMSYFEE---GGTLPTPF----------NVIPS----------------- ---------------------------------------------------PKSLWYLIK WIWTHL---------------------------------CKKK----------MRRKPES FGTI---------------------------------------GRRAADN---------- ---------------------------LRRHHQYQE--VMRN------------------ ----------------LVKRYVAAMIRDAKTEEGLTEEN---------------FK---- ----------------------------ELKQDISSFRFEVLGLLR-------------- ----------------------------------GSKLST-----IQSANA-SKESSNSA -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SD------------------------------------------------------ ---------------------------------------------------EKSD----- ---------------------------------------------SEGN-SKD--K---- ------------------------------------------------------------ ------------------------------------------------------------ -------KKNFSLFDL-----------------------------------TTLIHPRS- -----------AAIAS--------------ERHN-ISNGSA----------------LVV QEPPRE-----KQR----KVNFVTD-IK-------------------------NFGLFHR RSKQN---------------AA-----------------EQNANQIFS------VSEEVA RQQAAG------PLERNIQ----------------------------------------- ------------------------------------------------------------ --LESRGLAS---------------------------------------------RGD-L S-----------IP----------GLSEQC--------------VLVDHR---------- -----------------------ERNTDTLGLQVGKR--VCPFK-SEKVVVE-DTV---- ----PIIPKEKH--AKEEDSSIDYDLNLPDTVT-----HEDYVTTRL------------- ----- >Homo:sapiens_Human_ENSG00000072315_ChrX_Vertebrata_TRPC5 ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKKVN-- ------------------------------------------------------------ ----YSPYRDRIPLQIVRA----------------------------------------- --------------ETELSA-----------------------------EE--------- -----------KAF---------------------------------------------- ---------------LNAVEKGDYATVKQ------------------------------- ------------------------------------ALQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYYNVNI-------- ---------------------------NCMDPL--------------------------- ---GRS----ALLIAIE------------------------------------NENLEIM ELLLNHS----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLYAI RKEVVGAVELLLSYR--------RPSGEK------------------------------- ------------------------------------------------------------ -----QVPTLM------------------------------------------------- --------------------------------------MDTQFSEF-------------- ------TPDIT-------------PIMLAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKLLVQ------KRVTIPRPH------------- -----------------QIRCNCVECVSSSEVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYKAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----ILTAFRLGWELKELSKVE-NEFK------------------AEYEELSQQCKLFA KDL---LDQAR-SSRE-------------------------------------LEIILNH RDD-----------HSEELD----P--------QKYHDLAKLKVAIK-----YHQKEFVA QPNCQQLLATLWYDGFPGWRRKH------------------------------------- --------WVVKLLTCMTIGFLFPMLSI-------AYLISP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----RSNLGLFIKKPFIKFI-------CH-------------TASYLTFLFMLLL----- ----ASQHIVR------------------------------------------------- ------------------------------------------------------------ ----------------------------------------TDLHVQGPPPTVVEWMI-LP WVLGFIWGEIKEMWD--------------------------------------------- -----------------------------GGFTEY------IHDWWNLMDFAMNSLYLAT ISL-KIVAYVK-------------------YNGSR----------PREEWEMWHPTLIAE ALFAISNILSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET--------------------RAIDEPNN--CKGIRCEKQ-NNA-FST--LFET LQSLFWSVFGL---------------LNLY--------------------VTNVKARH-- ---------------------------------------------------------EFT EFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI------------EW------ ---KFARTKLWMSYFDE---GGTLPPPF----------NIIPS----------------- ---------------------------------------------------PKSFLYLGN WFNNTF---------------------------------CPKR-------DPDGRRRRRN LRSF---------------------------------------TERNADS---------- ---------------------------LIQNQHYQE--VIRN------------------ ----------------LVKRYVAAMIRNSKTHEGLTEEN---------------FK---- ----------------------------ELKQDISSFRYEVLDLL--------------- ----------------------------------GNRKHP------RSFSTSSTELSQRD -D-NND------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GSG GARAKSKS---------------------------------------------------- ----------------------------------------------VSFNL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GCKKKTCHG-----------------------------------PPLIRTMP- --------RSSGAQGK--------------SKAESSSKRSF------------------- ----------------------MGPSLK-------------------------KLGLLFS KFNGH---------------MS-----------------EPSSEPMYT------ISDGIV QQHC---------MWQDIRYSQME------------------------------------ ------------------------------------------------------------ -KGKAEACSQ---------------------------------------------SEINL S-----------EV-ELGEV-QGAAQSSEC-PLA-----CSS--SL--HCAS-------- --------------------------------------SICSSN-SKLLDSS-EDV---- ----FETWGEAC------------DL----LMHKWGDGQEEQVTTRL------------- ----- >Homo:sapiens_Human_ENSG00000137672_Chr11_Vertebrata_TRPC6 ------------------------------------------------------------ ----------------------------------MSQSPAFG------------------ ---------------------------PRRGSSP-------------------------- -----RGAAGAAARRNE---------------------------------SQDYLLMD-- ---------------------SELGEDGCPQAP--LPCYGYYPC--------FRGSDNRL AHRRQTVLREKGRRLANRGPAY---------------MF--------------------- -----------SDRSTSLSI-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ECH---SLNV-------- ---------------------------NCVDYM--------------------------- ---GQN----ALQLAVA------------------------------------NEHLEIT ELLLKKEN---------------------------------------------------- ------------------------------------------------------------ -------------------LSRVGD-----------------------------ALLLAI SKGYVRIVEAILSHPAFAEG--KRLATSP------------------------------- ------------------------------------------------------------ -----SQSELQQD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SHDVT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CQEYEIVHTLLR------KGARIERPH------------- -----------------DYFCKCNDCNQKQKHDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VMTALELSNELAVLANIE-KEFK------------------NDYKKLSMQCKDFV VGL---LDLCR-NTEE-------------------------------------VEAILNG -DV-----------E-TLQS----GDH-------GRPNLSRLKLAIK-----YEVKKFVA HPNCQQQLLSIWYENLSGLRQQT------------------------------------- --------MAVKFLVVLAVAIGLPFLAL-------IYWFAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKMGKIMRGPFMKFV-------AH-------------AASFTIFLGLLVMN---- ----AADRFEG-----------------------------TKLLPNETS-TDNAK----- ------------------------------------------------------------ ----------------------------------------QLFRMKTSCFSWMEMLI-IS WVIGMIWAECKEIWT--------------------------------------------- -----------------------------QGPKEY------LFELWNMLDFGMLAIFAAS FIA-RFMAFWHASKAQS--IIDANDTLKDLTKVTLGDNVKYYN-LARIKWDPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFN LYSYYIG------------------------------------AKQ-NEA-FTT--VEES FKTLFWAIFGL---------------SEVK--------------------SVVINYNH-- ---------------------------------------------------------KFI ENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADV------------EW------ ---KFARAKLWFSYFEE---GRTLPVPF----------NLVPS----------------- ---------------------------------------------------PKSLFYLLL KLKKWISELF----------------------------QGHKK----------GFQEDAE MNKI---------------------------------------NEEKKLGILGSHEDLSK LSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQK--IMKR------------------ ----------------LIKRYVLQAQIDKES-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQNTEDLA -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIRELG- ------------------------------------------------------------ ----------------------------------------------------EKLSMEPN QEETNR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000069018_Chr5_Vertebrata_TRPC7 ------------------------------------------------------------ ----------------------------------M------------------------- ---------------------------LRNSTF--------------------------- ------------------------------------------------------------ ----------------------------------------------------------KN MQRRHTTLREKGRRQAIRGPAY---------------MF--------------------- -----------NEKGTSLTP-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDSAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ESK---TLNF-------- ---------------------------NCVDYM--------------------------- ---GQN----ALQLAVG------------------------------------NEHLEVT ELLLKKEN---------------------------------------------------- ------------------------------------------------------------ -------------------LARVGD-----------------------------ALLLAI SKGYVRIVEAILNHPAFAQG--QRLTLSP------------------------------- ------------------------------------------------------------ -----LEQELRDD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SHDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CQEYEIVHILLL------KGARIERPH------------- -----------------DYFCKCNECTEKQRKDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RMNAYKGL-------------------------------------------- --------------------------------------ASAAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELARLANIE-TEFK------------------NDYRKLSMQCKDFV VGV---LDLCR-DTEE-------------------------------------VEAILNG -DV-----------NFQVWS----DH--------HRPSLSRIKLAIK-----YEVKKFVA HPNCQQQLLTMWYENLSGLRQQS------------------------------------- --------IAVKFLAVFGVSIGLPFLAI-------AYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGRTLRSPFMKFV-------AH-------------AVSFTIFLGLLVVN---- ----ASDRFEG-----------------------------VKTLPNETF-TDYPK----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTQFSWTEMLI-MK WVLGMIWSECKEIWE--------------------------------------------- -----------------------------EGPREY------VLHLWNLLDFGMLSIFVAS FTA-RFMAFLKATEAQL--YVDQHVQDDTLHNVSLPPEVAYFT-YARDKWWPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFN LYSYYRG------------------------------------AKY-NPA-FTT--VEES FKTLFWSIFGL---------------SEVI--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADV------------EW------ ---KFARAKLWLSYFDE---GRTLPAPF----------NLVPS----------------- ---------------------------------------------------PKSFYYLIM RIKMCLIKLC----------------------------KSKAK----------SCENDLE MGML---------------------------------------NSKFKKTRY-------- ------------QAGMRNSENLTANNTLSKPTRYQK--IMKR------------------ ----------------LIKRYVLKAQVDREN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQATGELA -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQQLS- ------------------------------------------------------------ ----------------------------------------------------EKFGKNLN KDHLRVNKG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KDI---- ------------------------------------------------------------ ----- >Mus:musculus_Mouse_ENSMUSG00000100254_Chr7_Vertebrata_TRPC2 ------------------------------------------------------------ ----------------------------------MDPLSP-------------------- ------------------------------------------------------------ -------------------------------------------------------QPN-- ------------------------------------------------------------ ------------------------------------------------------------ --------------WTEIVN-----------------------------KK--------- -----------LKFPPT------------------------------------------- --------------LLRAIQEGQLGLVQQ------------------------------- ------------------------------------LLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SSSDASGAGPGG------ ---------------------PLRNVEESEDRS--------------------------- ---WRE----ALNLAIR------------------------------------LGHEVIT DVLLANVKF--------------------------------------------------- ------------------------------------------------------------ ------------------DFRQIHE-----------------------------ALLVAV DTNQPAVVRRLLA----------RLEREK------------------------------- ------------------------------------------------------------ -----GR---KVDT---------------------------------------------- --------------------------KSFSLAFF---DSSIDGSRF-------------- ------APGVT-------------PLTLACQ----------------------------- ------------------------------------------------------------ --------------------KDLYEIAQLLMD------QGHTIARPH------------- -----------------PVSCACLECSNARRYDLLKFSLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINTYRGI-------------------------------------------- --------------------------------------ASRAH----------------- -------------------------------------------LSLASEDA--------- -----MLAAFQLSRELRRLARKE-PEFK------------------PQYIALESLCQDYG FEL---LGMCR-NQSE-------------------------------------VTAVLND LGED----------SETEPEAEGLGQA----FEEGIPNLARLRLAVN-----YNQKQFVA HPICQQVLSSIWCGNLAGWRGST------------------------------------- --------TIWKLFVAFLIFLTMPFLCI-------GYWLAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSQLGRLLKIPVLKFL-------LH-------------SASYLWFLIFLLG----- ----ESLVMET------------------------------------------------- ------------------------------------------------------------ ----------------------------------------QLSTFKGRSQSVWETSLHMI WVTGFLWFECKEVWI--------------------------------------------- -----------------------------EGLRSY------LLDWWNFLDVVILSLYLAS FAL-RLLLAGLAYMHCR--DASDST------------TCRYFTTAERSEWRTEDPQFLAE VLFAVTSMLSFTRLAYIL-PAHESLGTLQISIGKMI-DDMIRFMFILMIILTAFLCGLNN IYVPYQE----------------------------------------SEK-LGN--FNET FQFLFWTMFGMEEHT----------VVDMP--------------------QFLVP----- ------------------------------------------------------------ EFVGRAMYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADV------------EW------ ---KFARSKLYLSYFRE---GLTLPVPF----------NILPS----------------- ---------------------------------------------------PKAAFYLVR RIFRFL---------------------------------CCGS-------SCCKAKK-SD YPPI---------------------------------------G---------------- -TF--------TNPGARAGSAGE----GERVSYRLR--VIKA------------------ ----------------LVQRYIETARREFEETRRKDLGN--------------RLT---- ----------------------------ELTKTVSRLQSEVASVQ--------------- ----------------------------------KNLAA-------------GGAPRPP- -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GASILSR------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------YITRVR- ------------------------------------------------------------ --------------------NSFQNLGP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PTSDTPAELTM---------------------------------------PGIVETEVSL G--------DGLD--GTGEAGA---------PAPGEPGSSSSA-HVLVH----------- --------------------------------------REQEAE-GS------GDLLLEG D---LETKGES------------------------------------------------- ----- >Latimeria:chalumnae_Coelacanth_XP:006002842.1_NW:005819864.1_Vertebrata_TRPC1_TRPC1 -------------------------------------------------------MLMLP --------------------------DNLMGFCIMAAL---------------------- ------------------------------------------------------------ -----------------------------------------------------YQSTD-- ------------------------------------------------------------ ----SSSPNRFLALKDVREV---------------------------------------- --------------KEETTL-----------------------------DE--------- -----------KLY---------------------------------------------- ---------------LLASEKGDYYMVKK------------------------------- ------------------------------------LLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------E-KKNGELNI-------- ---------------------------NCVDVL--------------------------- ---GRN----AVTIAIE------------------------------------NENLDIL QLLLEHG----------------------------------------------------- ------------------------------------------------------------ --------------------CQTTD-----------------------------ALLVAI DSEVVGAVDILLNHRP-------RRSSKP------------------------------- ------------------------------------------------------------ -----TIAKLMQ------------------------------------------------ -------------------------------------RIQNPEYST-------------- ------TMDVA-------------PVILAAH----------------------------- ------------------------------------------------------------ --------------------RNNYEILTMLLK------QDISLPRPH------------- -----------------AVGCECTLCNAKNKKDSLRHSRF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLDIYRCL-------------------------------------------- --------------------------------------ASPAL----------------- -------------------------------------------IMLTEEDP--------- -----ILRAFELSVDLKELSLVE-VEFR------------------NDYEELAQQCKTFA KDL---LAQAR-NSRE-------------------------------------LEVILNH -TS-----------NDEPID----KRG----LLEERMNLSRLKLAIK-----YNQKEFVA QSNCQQFLNTVWFGQMAGYRRKH------------------------------------- --------TIVKILIVLTVAILWPVLSL-------CYLLAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSRVGHIIHTPFMKFI-------IH-------------SASYFTFLLLLNL----- ----YSLVYNE------------------------------------------------- ------------------------------------------------------------ ----------------------------------------DKKNTMGPAMEMIDCLL-IL WLIGMVWSDVKRLWY--------------------------------------------- -----------------------------DGLEDF------LEESRNQLSFVMNSLYLAT FAL-KIVAHNK-------------------FHAIA----------ERKDWDAFHPTLVAE GLFAFANILSYLRLFFMY-TTSSILGPLQISMGQML-QDFGKFLGMFLLVLFSFTIGLTQ LY-------------------DQG--FTVNEE---KNCEGIFCEQQSNRT-FYS--FIGT CYALFWYIFSLA-------------HVALF--------------------VTRFSYGE-- ---------------------------------------------------------ELQ SVVGAVIVGTYNVVVVIVLTKLLVAMLHNSFQLIANHEDK------------EW------ ---KFARAKLWLSYFDD---KCTLPPPF----------NIIPS----------------- ---------------------------------------------------PKTIYYLLT SLNKWI---------------------------------CSHT-------TAGKVKRQNS LKEW---------------------------------------RNLKQK----------- -----------------------------RDENYQK--VMCC------------------ ----------------LVHRYLTSMRQKMQSTDQATVEN---------------LN---- ----------------------------ELQQDLSKFRNEMRDLL--------------- ----------------------------------------------------GFRTS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYAMFYP RN---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006012787.1_NW:005822458.1_Vertebrata_TRPC1_TRPC4:partial ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKRAD-- ------------------------------------------------------------ ----NAPYRDRISLRIVRA----------------------------------------- --------------ESELSP-----------------------------AE--------- -----------KAY---------------------------------------------- ---------------LNAVEKGDYASVKQ------------------------------- ------------------------------------ALE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYFKINI-------- ---------------------------NCIDPL--------------------------- ---GRT----ALLIAIE------------------------------------NENLEII ELLLSFN----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLHAI RKEVVGAVELLLNHK--------KPSGEK------------------------------- ------------------------------------------------------------ -----QVPPIL------------------------------------------------- --------------------------------------LDKQFSEF-------------- ------TPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKHLVQ------KGVSIPRPH------------- -----------------EVRCNCVECVSSSDVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYKAL-------------------------------------------- --------------------------------------SSPSL----------------- -------------------------------------------IALSSEDP--------- -----FLTAFQLSWELQELSKVE-NEFK------------------SEYEELSRQCKQFA KDL---LDQTR-SSRE-------------------------------------LEIILNY RDN-----------NS-LLE----D--------QNTNDLARLKLAIK-----YHQKEFVA QPNCQQLLASRWYDEFPGWRRKH------------------------------------- --------WAVKFFTCVFIGLLFPVLSL-------SYLIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSTLGLFIRKPFIKFI-------CH-------------TASYLTFLFLLLL----- ----ASQRIVR------------------------------------------------- ------------------------------------------------------------ ----------------------------------------TDLDMQGPTPTIVEWMI-LP WVLGFIWGEIKQMWD--------------------------------------------- -----------------------------GGLQDY------IHDWWNLMDFVMNSLYLAT ISL-KIVAYVK-------------------YNGSR----------QREQWEMWHPTLVAE ALFAIANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET---------------------TAEELNG--CKGIRCEKQ-NNA-FST--LFET LQSLFWSIFGL---------------INLY--------------------VTNVKARH-- ---------------------------------------------------------EFT EFVGATMFGTYNIISLVVLLNMLIAMMNNSYQLIVDHADI------------EW------ ---KFARTKLWMSYFEE---GGTLPTPF----------NIIPS----------------- ---------------------------------------------------PKSTWYLLN WIKRHV---------------------------------CKKK----------ERRKPES FGTI---------------------------------------GRRAADN---------- ---------------------------VRKNHQYQE--VMRN------------------ ----------------LVKRYVAAMIRDAKTEEGLTEEN---------------FK---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006007350.2_NW:005820510.1_Vertebrata_TRPC1_TRPC3 ------------------------------------------------------------ ----------------------------------MSTKGKKLK----------------- --------------------------EQKRVSF--------------------------- ------------SEDD-----------------------------------QKWKEKN-- ---------------------GDLDSQNYRHIKTDREFLGYYPYSMPSA------GNPSL --RRMTMMREKGRRQAIRGPAF---------------MF--------------------- -----------NNRSTSLTA-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ESK---TLNV-------- ---------------------------NSVDYM--------------------------- ---GQN----ALQLAVG------------------------------------NEHLEVT ELLLKKEN---------------------------------------------------- ------------------------------------------------------------ -------------------LARIGD-----------------------------ALLLAI SKGYVRIVEAILNHSAFTAS--KRLTLSP------------------------------- ------------------------------------------------------------ -----SEQELQDD----------------------------------------------- -------------------------------DFF---SYDEDGTRF-------------- ------SPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CQKYDVVHMLLM------KGARIERPH------------- -----------------DYFCKCNECMEKQKHDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELAKLANIE-KEFK------------------NDYRKLSMQCKDFV VGV---LDLCR-DTEE-------------------------------------VEAILNG -DV-----------DAEQDE----SQ--------HRASLSRVKLAIK-----YEVKKFVA HPNCQQQLLTIWYENLSGLREQS------------------------------------- --------IAIKCLVVLVVALGLPLLAV-------GYWMAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSRLGKILRSPFMKFV-------AH-------------AASFIIFLCLLVFN---- ----ASDRFEG-----------------------------ITTLPNVTV-TDYPK----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTQFTWTEILI-MV WVLGMMWSECKELWI--------------------------------------------- -----------------------------EGPREY------ILQMWNVLDFGMLSIFIAA FTA-RFLAFLQATKAQD--YVDRNIDESDLSMVTLPPDIEYFT-YARDKWLPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVLFIMVFLAFMIGMFI LYSYYLG------------------------------------AKV-NSA-FTT--VEES FKTLFWSIFGL---------------SEVT--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDV------------EW------ ---KFARSKLWLSYFDD---GKTLPPPF----------SLVPS----------------- ---------------------------------------------------PKSFIYLIL KIIN----LF----------------------------RCRRR----------RLRQDVE MGMD---------------------------------------HAKSMLNLF-------- -----------TQSNPKISESHSFNSILNQPTRYQQ--IMKR------------------ ----------------LIKRYVLKAQVDKEN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQGTEELA -I---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQKLS- ------------------------------------------------------------ ----------------------------------------------------EKLNTSKT RCE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014352497.1_NW:005821178.1_Vertebrata_TRPC1_TRPC6:like ------------------------------------------------------------ ----------------------------------MSQQ---------------------- ----------------------------KRNALP-------------------------- -----NNDSPAAARRNV---------------------------------SQDYLLMN-- ---------------------ADLGEES-------------YLCEGN---LLYRNED-RI MHRRQTMHREKSRRQAIRGPAY---------------MF--------------------- -----------SDRSASLSS-----------------------------EE--------- -----------EIF---------------------------------------------- ---------------LEAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ECP---SLNV-------- ---------------------------NCVDYM--------------------------- ---GQN----VLQLAVV------------------------------------NEHLEIT ELLLKTEN---------------------------------------------------- ------------------------------------------------------------ -------------------LARVGD-----------------------------ALLLAI SKGYVRIVEAILNHPAFAEG--KRLATRP------------------------------- ------------------------------------------------------------ -----SESELQHD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SHDIS-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CLEYEIVYILLR------KGARIERPH------------- -----------------DYFCKCSECNEKQKHDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELAVLANIE-KEFK------------------NDYKKLSIQCKDFV VGL---LDLCR-NTEE-------------------------------------VEAILNG -NV-----------EATSND----GEC-------GRPSLSRLKLAIK-----YEVKKFVA HPNCQQQLLSIWYENLSGLRQQT------------------------------------- --------IAIKFLVVLAVAVGLPFLAF-------NYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGKIMRAPFMKFV-------AH-------------AASFTIFLGLLVMN---- ----AADRFEG-----------------------------TKLRPNENH-TDHPK----- ------------------------------------------------------------ ----------------------------------------QLFRMKTSCFSWMEMLI-IS WVLGMIWSECKEIWS--------------------------------------------- -----------------------------QGPREY------LFELWNILDFGMLAIFVAS FIA-RFMAFWHASRAQK--YVNSKN-ISNICNASLPSEVEYYK-LARIHWVPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFN LYSYYLG------------------------------------AKQ-NDA-FTT--VEES FKTLFWAIFGL---------------SEVK--------------------SVVINYGH-- ---------------------------------------------------------KFI ENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ALSKFI------------------------------------------------------ ------------------------------------------------------------ -------------------------QFNGTP----------------------------- --------------------YIFFVDIQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006003125.1_NW:005819899.1_Vertebrata_TRPC1_TRPC2:like -------------------------------------------------------MVCAP ---------------------------------SRTQVFPVLF----------------- ------------------------------------------------------------ --------------------------------------------------FLSKQDAN-- ------------------------------------------------------------ ------------------------------------------------------------ --------------WREIVN-----------------------------KK--------- -----------MKFPIA------------------------------------------- --------------LISAIQDGNLLHVRQ------------------------------- ------------------------------------LVQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SND--------G------ ---------------------ILRQLDETEDRS--------------------------- ---WRE----ALNLAIR------------------------------------MGKTDIV SALLQYVKF--------------------------------------------------- ------------------------------------------------------------ ------------------DFRQIHE-----------------------------ALLVAV DTNQPLVVKSLLD----------RLDQEK------------------------------- ------------------------------------------------------------ -----SM---KVDI---------------------------------------------- --------------------------KSFSLAIF---DNSIDNSRY-------------- ------APGVT-------------PLTLACQ----------------------------- ------------------------------------------------------------ --------------------KDLYEIVDMLMK------KGHDISAPH------------- -----------------KISCTCLECSNARQYDLLKFSLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINTYKGI-------------------------------------------- --------------------------------------ASRAY----------------- -------------------------------------------LSIASEDA--------- -----MLRAFKLSRELKRLSNKE-PEFK------------------PEYLALEELCQDFA VEL---LGMCR-NQSE-------------------------------------VTAVLND SGDD----------TED-LD----NQA----FEEGIPNLSRLRLAVN-----YNQKRFVA HPICQQVLSSIWCQSLSSWRGSR------------------------------------- --------TTWKLFIAFGAFITMPLLCL-------MYWLAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSKVGKTLKIPVIKFI-------LH-------------SASYLWFLVFLLV----- ----ESIIMEQ------------------------------------------------- ------------------------------------------------------------ ----------------------------------------NREAFSSRNQTIYENSFHMV WVIGFFWYECKEVWI--------------------------------------------- -----------------------------EGLRSY------LLDWWNFLDIVILSMYLAS FSL-RVLVALKGYLYCL--YWPMSS------------DCYYFTKAEREEWRTEDPQFIAE VLFAVTSMLSFTRLASIL-PAHESLGTLQISIGKMI-DDMMRFMFILMIIGTAFLCGLNN IYVHYPE----------------------------------------FER-LGQ--LNET FQFLFWTMFGMEEHS----------VVDMP--------------------QFMVA----- ------------------------------------------------------------ ELVGRILYGIFTMVMVIVLLNMLIAMITNSFQKIEDDADV------------EW------ ---KFARSKLYLGYFRE---GLTLPVPF----------NIIPT----------------- ---------------------------------------------------PKAVFYMIR KIFRVF---------------------------------CC----------AKEKKRYSD YPPI---------------------------------------P---------------- -SL--------VSISSRTGNGGE----ANRTSYRLQ--VIKA------------------ ----------------LVQRYIDTARREFEEGRRKDLGN--------------RIT---- ----------------------------ELNKAVVRLHTEVKQLR--------------- ----------------------------------RNVME-------------SRASSKP- -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GASILGK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------YILGAK- ------------------------------------------------------------ --------------------NKFRDYDQ------------------------DSVASTSS RTNNE--------------------------------------------HSQVTVHQQ-- ----------------DGNDTQVQPA---------------------------------- -----------------------------------------EKQEEEKE----------E EPVEEEEEEEL---------------------------------------EDISPTDSKT S--------EGTDT-GIG------------------------------------------ ---------------------------------------TEDEN-NE------------- ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014339491.1_NW:005823610.1_Vertebrata_TRPC1_TRPC5:partial ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----FIWAEIKEMWD--------------------------------------------- -----------------------------GGFTEY------VHDWWNLMDFAMNSLYLAT ISL-KLVAYIK-------------------YNGSR----------PREEWEMWHPTLVAE ALFAIANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET--------------------SASEEPNN--CKGIRCEKQ-NNA-FST--LFET LQSLFWSIFGL---------------LNLY--------------------VTNVKARH-- ---------------------------------------------------------EFT EFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI------------EW------ ---KFARTKLWMSYFDE---GGTLPAPF----------NIIPS----------------- ---------------------------------------------------PKSVWYLCV WIHKRL---------------------------------CPHK-------DLEKEQKHEN LKTF---------------------------------------TELHADN---------- ---------------------------LIQNKHYQE--VIRN------------------ ----------------LVKRYVAAMIRSAKTDEGLTEEN---------------FK---- ----------------------------ELKQDISSFRYEVLDLL--------------- ----------------------------------GNRKPP-----RRSYSTSSTEVSQKE -D-LNE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ESG RDRHKQKS---------------------------------------------------- ----------------------------------------------VSFNL--------- ----------------------------------------------ADE----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------RNDPFCV-----------------------------------SALIKSMS- --------GIEITEEK--------------QKSNGLSKRSF----------------LK- ----------------------NGNSFK-------------------------RLGLLFS KMNGH---------------LS-----------------EQNSEPMHT------ISDGLL QPQY---------MWKDFKYSQ-------------------------------------- ------------------------------------------------------------ -IVQNKEATQ---------------------------------------------SEINL N-----------EV-GLSETNKLELRDSHC-PSV-----CTN--SL--HCGS-------- --------------------------------------RVCTSN-SKLIDST-EEV---- ----FDSWGDAC------------DM----FLNKWKEGTEEHITTQL------------- ----- >Latimeria:chalumnae_Coelacanth_XP:006000310.1_NW:005819598.1_Vertebrata_TRPC1_TRPC5:like ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKKVS-- ------------------------------------------------------------ ----YSPYRDRIPLQIVRA----------------------------------------- --------------EVELSP-----------------------------EE--------- -----------KAY---------------------------------------------- ---------------LNAVEKGDYASMKH------------------------------- ------------------------------------ALE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYYNINI-------- ---------------------------NCMDPL--------------------------- ---GRS----ALLIAIE------------------------------------NENLEIM ELLLSHN----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLYAI RKEVVGAVELLLNHR--------KPSGEK------------------------------- ------------------------------------------------------------ -----QVPALM------------------------------------------------- --------------------------------------MDTQFSEF-------------- ------TPDIT-------------PIMLAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKLLVQ------RRVTIPRPH------------- -----------------QIRCNCVECVSSSEVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYKAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----ILTAFRLGWELKELSKVE-NEFK------------------AEYEELSQQCKHFA KDL---LDQAR-SSRE-------------------------------------LEIILNH RDD-----------QSEELD----P--------QKCHDLAKLKLAIK-----YHQKEVSS K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------QSVTLAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RVF---------------------------------------GERQA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----RQKH---------------------------------------------------- ----------------------------------------------LTF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QSF----------------I-- ----------------------------------------------------------FM DLN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------P--------SK--AF-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006011645.1_NW:005821814.1_Vertebrata_TRPC1_TRPC7:partial ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LTAL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------KIALL-----QKICKFVA HPNCQQQLLTIWYEHLSGLRQQS------------------------------------- --------VAVKCLTVFGVTLGLPFLAI-------AYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGHILRSPFMKFV-------AH-------------AMSFTIFLGLLVLN---- ----ASDRFEG-----------------------------VKNLPNETI-TDHPR----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTQFSWTELLI-MK WILGMIWSECKEIWE--------------------------------------------- -----------------------------EGPREY------VLHLWNLLDFGMLSIFVAS FTA-RFMAFLKAREAQQ--YVDQNV-NSTISNASLPPEVAYFT-YARNRWLPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFN LYSYYLG------------------------------------AKY-NPA-FTT--VEES FKTLFWSIFGL---------------SEVI--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGIYNVTMVVVLLNMLIAMINNSYQEIEEDADV------------EW------ ---KFARAKLWLSYFDE---GRTLPAPF----------NLVPS----------------- ---------------------------------------------------PKSFYYLTL KIKWCFIQLC----------------------------KLKSK----------RCENDLE MGML---------------------------------------NSKPKHHQY-------- ------------DPRCQSSDSSSLRKPIGKPTRYQK--IMKR------------------ ----------------LIKRYVLKAQVDREN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQATGELA -H---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQQLS- ------------------------------------------------------------ ----------------------------------------------------DKFGKNLN K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006637772.1_LG14_Vertebrata_TRPC1_TRPC1 M-----------------------------------------------------HINVLP --------------------------YSFS--VIMAAL---------------------- ------------------------------------------------------------ -----------------------------------------------------YQSTD-- ------------------------------------------------------------ ----SSSPDKYLALKDVREV---------------------------------------- --------------KEETTL-----------------------------DE--------- -----------KLF---------------------------------------------- ---------------LLACEKGDYYMVKK------------------------------- ------------------------------------LLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------E-KRHGDFNI-------- ---------------------------NCVDVL--------------------------- ---GRN----AVTISIE------------------------------------NENLDIL QLLLDHG----------------------------------------------------- ------------------------------------------------------------ --------------------CQTTD-----------------------------ALLVAI DSEVVGAVDILLNHRP-------RRSSKP------------------------------- ------------------------------------------------------------ -----SIAKLIH------------------------------------------------ -------------------------------------RIQNPEYST-------------- ------TMDVA-------------PVILAAH----------------------------- ------------------------------------------------------------ --------------------RNNYEILTMLLK------QDISLPRPH------------- -----------------AVGCECTLCNVKNKKDSLRHSRF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLDIYRCL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IMLTEEDP--------- -----ILRAFELSADLKELSLVE-VEFR------------------NDYEELAKQCKMFA KDL---LAQAR-NSRE-------------------------------------LEVILNH -TS-----------SDEHVD----KRG----LLEERMNLSRLKLAIK-----YNQKEFVA QSNCQQFLNTVWFGQTASYRRKH------------------------------------- --------TCLKILTVLTVAVLWPILSV-------CYLLVP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----RSRVGQVIHTPFMKFI-------IH-------------MASYFTFLLLLNL----- ----YSLVYNE------------------------------------------------- ------------------------------------------------------------ ----------------------------------------GKKNTMGPALEMIDYLL-IL WIIGMVWSDVKRLWY--------------------------------------------- -----------------------------EGLEDF------LEESRNQLSFVMNSLYLST FAL-KVVAHHK-------------------FKNIQN------T-EDRKNWDAFHPILVAE GLFAFANVLSYLRLFFMY-TTSSILGPLQISMGQML-QEFGKFLGLFLLVLFSFTIGLTQ LY-------------------GKD--QKDPSKSGGKDCEGIFCEQQSNDT-FYS--FIGT CYALFWYIFSLA-------------HVALF--------------------VTRISYTE-- ---------------------------------------------------------ELR SFVGALIVGTYNIVVVIVLTKLLVAMLHKSFQQIANHEDK------------EW------ ---KFARAKLWLSYFDD---KCTLPPPF----------NIIPS----------------- ---------------------------------------------------PKTVCYLVT SLSKWI---------------------------------CSHT-------TAGKVKRQNS LKEW---------------------------------------RTLKQK----------- -----------------------------RDENYQK--IMCC------------------ ----------------LVHRYLTSTRQKLQSTDQATVEN---------------LN---- ----------------------------DLRQDLSKFRNEMRDLL--------------- ----------------------------------------------------GFRTS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYAMFYP RS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006628285.1_LG3_Vertebrata_TRPC1_TRPC4 ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKRTD-- ------------------------------------------------------------ ----NSSYRDRIPLRIVRA----------------------------------------- --------------ESELSP-----------------------------AE--------- -----------KAY---------------------------------------------- ---------------LSAVEKGDYASVKQ------------------------------- ------------------------------------ALE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYFKINI-------- ---------------------------NCIDPL--------------------------- ---GRT----ALLIAIE------------------------------------NENLEII ELLLSFN----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLHAI RKEVVGAVELLLNHK--------KPSGEK------------------------------- ------------------------------------------------------------ -----QVPPIL------------------------------------------------- --------------------------------------LDKQFSDF-------------- ------TPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKLLVQ------KGVSVPQPH------------- -----------------EVRCNCVECVSSSDVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYKAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----FLTAFQLSWELQELSKVE-NEFK------------------SEYEELSHQCKQFA KDL---LDQTR-SSRE-------------------------------------LEMILNF RDD-----------TN-LLE----D--------ENNNDLARLKLAIK-----YRQKEFVA QPNCQQLLASRWYDEFPGWRRRH------------------------------------- --------WAGKFLTCVFIGLMFPVFSI-------FYLIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSRYGLFIRKPFIKFI-------CH-------------TASYLTFLFLLLL----- ----ASQHVVK------------------------------------------------- ------------------------------------------------------------ ----------------------------------------TEPNRQGPAPTTVEWMI-LP WVLGFIWTEIKQMWD--------------------------------------------- -----------------------------GGLQDY------IHDWWNLMDFVMNSLYLAT ISL-KIVAYVK-------------------YSDCK----------SRQQWEMWHPTLVAE AVFAIANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET--------------------EPSKENNY--CKGIRCEKQ-NNA-FST--LFET LQSLFWSIFGL---------------ISLY--------------------VTNVNAQH-- ---------------------------------------------------------EFT EFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI------------EW------ ---KFARTKLWMSYFEE---GGTLPAPF----------NIIPS----------------- ---------------------------------------------------PKSVWYLIK WIKRHI---------------------------------CKNA----------RAKRPES LGSL---------------------------------------GRRAAEN---------- ---------------------------LRINHQYQE--VLRN------------------ ----------------LVKRYVAAMIRDAKTEEGLTEEN---------------FK---- ----------------------------ELKQDISSFRYEVLGLMK-------------- ----------------------------------GNK-SS-----MPGSKL-NIGASNLP -H---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SEEQ---------------------------------------------------- ----------------------------------------------FKYSP--------- ----------------------------------------------AVS-DAQ--P---- ------------------------------------------------------------ ------------------------------------------------------------ -------KSKLNLYNV-----------------------------------TTLLQQSS- -----------GSKAS--------------ETYNGLINGSA----------------ILV SESSRE-----KGQ----RKDFPKD-IS-------------------------NFALFHR RQKVT---------------NP-----------------GQNAGKIYS------VSEEVD EYEP----------EEIARIAEVP------------------------------------ ------------------------------------------E----------------- -KAESSANKQ---------------------------------------------LETGL ---------------------------KECDDEL-----DKE--VV--HELS-------- --------------------------------------AYCDPS-ERSPEDT-ENP---- ----QEMPGEKHNESTEKNQEIE-------IME-----HESEL----------------- ----- >Lepisosteus:oculatus_Spotted:gar_XP:015206809.1_LG7_Vertebrata_TRPC1_TRPC5 ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKKVN-- ------------------------------------------------------------ ----YSPYRDRIPLQIVRA----------------------------------------- --------------EAELSL-----------------------------EE--------- -----------KAY---------------------------------------------- ---------------LTAVEKGDYASVKH------------------------------- ------------------------------------ALE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYYNINI-------- ---------------------------NCMDPL--------------------------- ---GRS----ALLIAIE------------------------------------NENLEIM ELLLCHN----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLYAI RKEVVGAVELLLNYR--------KPSGEK------------------------------- ------------------------------------------------------------ -----QVPSLM------------------------------------------------- --------------------------------------MDNQFSEF-------------- ------TPDIT-------------PIMLAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKLLVQ------RKVTIPRPH------------- -----------------QIRCNCVECVSSSEVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYKAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----ILTSFRLGWELKELSKVE-NEFK------------------AEYEELSQQCKRFA KDL---LDQAR-SSRE-------------------------------------LEIILNH RDD-----------QSEELD----P--------QKCHDLAKLKLAIK-----YHQKEFVA QPNCQQLLATLWYDGFPGWRRRH------------------------------------- --------WAVKLLTCFTIGLLFPVFSV-------IYLIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSSLGLFIKKPFIKFI-------CH-------------TASYLTFLFLLLL----- ----ASQHIVR------------------------------------------------- ------------------------------------------------------------ ----------------------------------------TNLHMQGPPPTIVEWMI-LP WVLGFIWAEIKEMWD--------------------------------------------- -----------------------------GGFTEY------VHDWWNLMDFAMNSLYLAT ISL-KIVAYVK-------------------YNSSR----------PREEWEMWHPTLIAE ALFAIANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET--------------------KASDEPNH--CKGIRCEKQ-NNA-FST--QQKS ------------------------------------------------------------ ------------------------------------------------------------ -------------------------QLQVSFETPQDHADI------------EW------ ---KFARTKLWMSYFDE---GGTLPPPF----------NIVPS----------------- ---------------------------------------------------PKSIWYLFV WLHRKL---------------------------------CSRRR------QEEEQKKHEN FRAF---------------------------------------TERHADN---------- ---------------------------LIQNQHYQE--VIRN------------------ ----------------LVKRYVAAMIRSAKTDEGLTEEN---------------FK---- ----------------------------ELKQDISSFRYEVLDLL--------------- ----------------------------------GNRKPP-----RRTYSS-SSEATLKD -EANED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EDG GRDKSSKS---------------------------------------------------- ----------------------------------------------VSFSL--------- ----------------------------------------------AEK----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------KKDAFSV-----------------------------------SALFKSMS- --------GADVAEDK--------------PKS-NGLRRSF----------------IK- NGNRLQ-----R------LSSSKKDSFK-------------------------RLGLLFS KMNGH---------------LS-----------------EPNSEPMYT------ISDGLL QPQY---------MWQDFKHS--------------------------------------- ------------------------------------------------------------ -LANDREVTR---------------------------------------------SEIHL N-----------EV-GLTQPAQVNGKDSLVPPV------GSK--SL--HCAS-------- --------------------------------------NITASN-SRLIDST-EDV---- ----FDSWEGGC------------DG----LIRKWRQGQEDIVSTQL------------- ----- >Lepisosteus:oculatus_Spotted:gar_XP:015197190.1_LG3_Vertebrata_TRPC1_TRPC6 ------------------------------------------------------------ ----------------------------------M------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PKGRRQAVRGPAY---------------MF--------------------- -----------NARASSLSA-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ELP---GLNV-------- ---------------------------NCVDYM--------------------------- ---GQN----ALQLAVA------------------------------------NEHLEVT ELLLKKDN---------------------------------------------------- ------------------------------------------------------------ -------------------LARIGD-----------------------------ALLLAI SKGYVRIVEAILSHKAFFNA--KRLTTSP------------------------------- ------------------------------------------------------------ -----SQSEIQHD----------------------------------------------- -------------------------------DFF---AYDEDGTRF-------------- ------SHDVT-------------PIILASH----------------------------- ------------------------------------------------------------ --------------------CYEYEIVHILLA------KGARIERPH------------- -----------------DYFCKCTTCSDNQKHDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VLCALELSNELAVLANIE-KEFK------------------NDYKKLSMQCKDYV VGL---LDLCR-NTEE-------------------------------------VEAILNG -DV-----------DLNPSS----EQH-------GRPNLIRLKLAIK-----YELKKFVA HPNCQQQLLSIWYENLSGLRQQK------------------------------------- --------TAVKFLVVLGVAIGLPFLAM-------IYWISP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGKIMRGPFMKFV-------AH-------------AASFTIFLGLLVLN---- ----ASDRFEG-----------------------------AAPPSNKSN-TDN------- ------------------------------------------------------------ ----------------------------------------QLYRMQTTIFTWMEMLI-IS WVIGMIWAECKEIWS--------------------------------------------- -----------------------------QGPREY------LLEPWNLLDFGMLAIFVAS FIA-RFMAYWHAYRAQC--YINMNN-VKNLTNASLPYEIKYYT-FYRKYWLPSDPQLISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFILVFLAFMIGMFN LYSHYFT------------------------------------EKQ-NKA-FTT--IEES FKTLFWAIFGL---------------SEVK--------------------TVVIGNDH-- ---------------------------------------------------------KFI ENIGYVLYGVYNVTMVIVLLNMLIAMINNSFQEIEDDADV------------EW------ ---KFARAKLWFSYFEE---GRTLPVPF----------NLIPS----------------- ---------------------------------------------------PKSVVCLVL KIKQFLKVLL----------------------------RIQKT----------DTNGDAE LNEL-------------------------------------------------------- --------GSDMHSTVRSS---------NSPTRYQK--IMKR------------------ ----------------LIKRYVFKAQIDKES-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SHNTEDLA -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIRKLG- ------------------------------------------------------------ ----------------------------------------------------EKLSIQTA HQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015205153.1_LG6_Vertebrata_TRPC1_TRPC7 ------------------------------------------------------------ ----------------------------------M------------------------- ---------------------------LQRSGS--------------------------- ------------------------------------------------------------ ----------------------------------------------------------EV MHRRHTTLREKGRRQAIRGPAY---------------MF--------------------- -----------NEKGTSLTA-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ESK---TLNF-------- ---------------------------NCVDYM--------------------------- ---GQN----SLQLAVG------------------------------------NEHLEVT ELLLKKDN---------------------------------------------------- ------------------------------------------------------------ -------------------LARVGD-----------------------------ALLLAI SKGYVRIVEAILNHPAFAGG--LRLTLSP------------------------------- ------------------------------------------------------------ -----LEQELRDD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SHDIT-------------PVILAAH----------------------------- ------------------------------------------------------------ --------------------CQEYEIVHILLM------KGARIEKPH------------- -----------------DYFCKCHECTEKQRKDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RMNAYKGL-------------------------------------------- --------------------------------------ASAAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELARLANIE-TEFK------------------NDYRKLSMQCKDFV VGV---LDLCR-DTEE-------------------------------------VEAILNG -DV-----------DQVPQG----DH--------HRPCLSRVKLAIK-----YEVKKFVA HPNCQQQLLTIWYENLSGLRQQS------------------------------------- --------IGVKCLTVLGVTIGLPFLAI-------AYWIMP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGQILRSPFMKFV-------AH-------------AVSFTIFLGLLVIN---- ----ASDRFEG-----------------------------VKNLPNETI-TDHPR----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTQFSWTEMLI-MK WVLGMIWSECKEIWA--------------------------------------------- -----------------------------DGPREY------VMHLWNVLDFGMLSIFVAS FTA-RLMAFLKASKAQL--YVDLHVPNNDLSNASLPAEVAYFT-YARNKWLPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFN LYSYYLG------------------------------------AKY-NPA-FTT--VEES FKTLFWSIFGL---------------SEVI--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADV------------EW------ ---KFARAKLWLSYFDE---GRTLPAPF----------NLVPS----------------- ---------------------------------------------------PKSFYYLIL HTKSCLIRLC----------------------------KAKAK----------KSDSDVE MGML---------------------------------------NSKPKPDRY-------- ------------KSSSRTLDSFGVKKPIKNPTRYQK--IMKR------------------ ----------------LIKRYVLKAQVDREN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQATGELA -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQQLS- ------------------------------------------------------------ ----------------------------------------------------DKFGKNMK KP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006629229.2_LG4_Vertebrata_TRPC1_TRPC3 ------------------------------------------------------------ ----------------------------------MSAKGRKY------------------ ---------------------------QKRVSF--------------------------- ------------SEEDN---------------------------------EQDWKEEN-- ---------------------GGLDAHYLKSVKTVRDSSGYYHCTMPAG------DNPTL --RRLTMMREKGRRQAVRGPAF---------------MF--------------------- -----------NNRGTSLTT-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ESS---TLNV-------- ---------------------------NCVDYM--------------------------- ---GQN----GLQLAVG------------------------------------NEHLEVT ELLLKRDN---------------------------------------------------- ------------------------------------------------------------ -------------------LARIGD-----------------------------ALLLAI SKGYVRIVEAILNHPAFVTS--ERLTRSP------------------------------- ------------------------------------------------------------ -----C--ELQDD----------------------------------------------- -------------------------------DFY---SYDEDGTRF-------------- ------SPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CQKYEVVHMLLM------KGARIERPH------------- -----------------DYFCKCNECMEKQKKDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYRGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELAKLANIE-KEFK------------------NDYRKLSMQCKDFV VGV---LDLCR-DTEE-------------------------------------VEAILNG -DV-----------SAELEE----GQH-------HRTLLSRVKLAIK-----YEVKKFVA HPNCQQQLLTIWYENLSGLREQT------------------------------------- --------IAVKCLVVLVVALGLPLLAV-------GYWFAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSRLGKILRSPFMKFV-------AH-------------AASFIIFLCLLVFN---- ----ASDRFEG-----------------------------ITTLPNVTV-TDYPK----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTRFSWTEMLI-MV WVLGMMWSECKELWM--------------------------------------------- -----------------------------EGPREY------ILQLWNVLDFGMLSIFIAA FTA-RFFAFLQATKAQQ--YVDEKIHVSDLSMVTLPPDIEYFT-YARDKWLPSDPQLISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVLFIMVFLAFMIGMFI LYSYYLG------------------------------------AKV-NPA-FTT--VEES FKTLFWSIFGL---------------SEVS--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDADV------------EW------ ---KFARSKLWLSYFDN---GKTLPPPF----------SLVPS----------------- ---------------------------------------------------PKSFWHCIK RVVN----LF----------------------------KCRRR----------RLKKDIE LGMD---------------------------------------NSKSRLNLF-------- -----------TQSNLKIAESHSFNSILNQPTRYQQ--IMKR------------------ ----------------LIKRYVLKAQVDKEN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEDK--------------- ----------------------------------------------------SQATEELS -L---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQKLS- ------------------------------------------------------------ ----------------------------------------------------DKLNINTT RCE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015196659.1_LG3_Vertebrata_TRPC1_TRPC2:like ------------------------------------------------------------ ----------------------------------MENLTP-------------------- ------------------------------------------------------------ --------------------------------------------------------EQ-- ------------------------------------------------------------ ------------------------------------------------------------ --------------WREIVN-----------------------------KK--------- -----------MRFPPE------------------------------------------- --------------LITAIQEGNSVQVAG------------------------------- ------------------------------------LLK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AGD--------G------ ---------------------ILRQLDDSEDRL--------------------------- ---WRE----ALNLAIR------------------------------------LGNEDTL DTLLQCVKF--------------------------------------------------- ------------------------------------------------------------ ------------------DFRQIHE-----------------------------ALLVAV DTNQPRVVKRLLD----------RLDQEK------------------------------- ------------------------------------------------------------ -----GVGNNKVDV---------------------------------------------- --------------------------RSFSLAIF---DHSIDDSQF-------------- ------APGVT-------------PLTLACQ----------------------------- ------------------------------------------------------------ --------------------KDLYEIVNMLTK------KGHVIPLPH------------- -----------------KISCVCLECRNGRQYDLLKFSLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINTYRGI-------------------------------------------- --------------------------------------ASRAY----------------- -------------------------------------------LSITTEDA--------- -----MLSAFRLSRELRKLSKKE-PEFK------------------PQYLSLEELCQEFA VEL---LGMCR-NQSE-------------------------------------VTTILNN CGDD----------DEDELD----EHT----FEEGIPSLARLRLAVN-----LNQKQFVA HPICQQVLSSIWCGNLSGWRGSR------------------------------------- --------TIWKLFISFGIFLTMPFLCM-------IYYVAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSKIGKTLKIPVIKFL-------LH-------------SASYLWFLIVLLG----- ----ESIVMEM------------------------------------------------- ------------------------------------------------------------ ----------------------------------------YRDQSSLREQSLMKNSIHMI WVVGFFWFECKEVWI--------------------------------------------- -----------------------------EGLRSY------LLDWWNFLDMMVLSMYLAS FTL-RVLILLKGYFLCL--GPDTML------------DCTYFTETARQDWRQEDPQFIAE VLFAMTSMLSFTRLAYIL-PAHESLGTLQISIGKMI-DDMMRFMFILMIIGTAFLCGLNN IYVPYVI----------------------------------------SPR-LGK--FNET FRFLFWTMFGVVNQD----------YVDMP--------------------DFVVA----- ------------------------------------------------------------ ETVGKILYGVYTLVIVIVLLNMLIAMITNSFQKIEDDADV------------EW------ ---KFARSKLYLSYFRE---GLTIPVPF----------NIIPS----------------- ---------------------------------------------------PKSLFYLLR GIFQKI---------------------------------CC----------CCKLSREPN YPPI---------------------------------------A---------------- -SI--------SNGTLNDSGGSG----ENRMSYRLQ--VIKA------------------ ----------------LVQRYIETARREFEETKRKDVGN--------------RIT---- ----------------------------ELNKVVTKLHFELKRIR--------------- ----------------------------------QNLNH-------------GSNTSPPE LD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------STGILGR------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------YILGAK- ------------------------------------------------------------ --------------------NNFKDFDK------------------------GEVGVGHA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PPVSVVHHREM----------------------------------------DVSETEE-- ---------------GVG------------------------------------------ ---------------------------------------QMEGE-GQ------------- ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007890880.1_NW:006890054.1_Vertebrata_TRPC1_TRPC1 ------------------------------------------------------------ ----------------------------------MANL---------------------- ------------------------------------------------------------ -----------------------------------------------------YQSTE-- ------------------------------------------------------------ ----SSSPNKYLALKDVREV---------------------------------------- --------------KEETTI-----------------------------DE--------- -----------KLF---------------------------------------------- ---------------LLACEKGDYYMVKK------------------------------- ------------------------------------LLD--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------E--KTGELNI-------- ---------------------------NCVDVL--------------------------- ---GRN----AVTIAIE------------------------------------NENLDIL QLLLDHG----------------------------------------------------- ------------------------------------------------------------ --------------------CQTTD-----------------------------ALLVAI GSEVVGAVDILLNHRP-------RRSSKP------------------------------- ------------------------------------------------------------ -----TIAKLMQ------------------------------------------------ -------------------------------------RIQNPEYST-------------- ------TMDVA-------------PVILAAH----------------------------- ------------------------------------------------------------ --------------------RNNYEILTMLLK------QDVSLPRPH------------- -----------------AVGCECTLCNAKNKKDSLRHSRF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLDIYRCL-------------------------------------------- --------------------------------------SSPSL----------------- -------------------------------------------IMLTEEDP--------- -----ILRAFELSADLKELSLVE-VEFR------------------NDYEQLAQQCKTFA KDL---LAQAR-NSRE-------------------------------------LEVILNH -TS-----------SDEPID----KRG----LLEERMNLSRLKLAIK-----YDQKEFVA QSNCQQFLNTVWFGQMASYRRKH------------------------------------- --------TCKKILICLTVAALWPVLSL-------CYLLAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSRVGKVIHTPFMKFI-------IH-------------SASYCTFLLLLNL----- ----YSLVYNE------------------------------------------------- ------------------------------------------------------------ ----------------------------------------DEKNTMGPALEMIDYLL-II WIFGMVWSDMKRLWY--------------------------------------------- -----------------------------EGLEDF------LDESRNQLSFVMNSLYLAT FAL-KVVAHSK-------------------FHAIG----------DRKNWDAFHPTLVAE GLFAFGNVLSYLRLFFMY-TTSSILGPLQISMGQML-QDFGKFLGLFLLVLISFTIGLTQ LF-------------------DKD--YLTAQN---KDCGAISCEQQSNNNIFHS--FIGT CYALFWYIFSLA-------------HVALF--------------------VTRFSYTD-- ---------------------------------------------------------ELQ SFVGAVVIGTYNVVVVIVLTKLLVAMLHKSFRLIANHEDK------------EW------ ---KFARAKLWLSYFDD---KSTLPPPF----------NIIPS----------------- ---------------------------------------------------PKTICYLFT SLNKWI---------------------------------CSRT-------SVGKVKRQNS LKEW---------------------------------------RNLKHK----------- -----------------------------RDENYQK--VMCC------------------ ----------------LVHRYLTTMRQKMHSTDQATEEN---------------LG---- ----------------------------ELRQDLSKFRNEMRDLL--------------- ----------------------------------------------------GFRTS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYAMFYQ RN---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007892158.1_NW:006890055.1_Vertebrata_TRPC1_TRPC5 ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKKVN-- ------------------------------------------------------------ ----YSPYIDRIPLQIVRA----------------------------------------- --------------ENELSL-----------------------------EE--------- -----------KAY---------------------------------------------- ---------------LNAVEKGDYASVKQ------------------------------- ------------------------------------GLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYFNINI-------- ---------------------------NCTDPL--------------------------- ---GRS----ALLIAIE------------------------------------NENLEIM ELLLSFS----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLYAI RKEVVGAVELLLRYR--------KPSGEK------------------------------- ------------------------------------------------------------ -----QVPPLL------------------------------------------------- --------------------------------------MDAQFSEF-------------- ------TPDIT-------------PIMLAAH----------------------------- ------------------------------------------------------------ --------------------TNNYEIIKLLVQ------RGVSIPRPH------------- -----------------QVRCNCVECVSSSEVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYRAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----ILTAFQLGWELKELSKVE-NEFK------------------AEYEELSQQCKRFA KDL---LDQAR-SSRE-------------------------------------LEIILNH RDD-----------QSDELD----L--------QKCHDLAKLKLAIK-----YHQKEFVA QPNCQQLLATLWYDGFPGWRRRH------------------------------------- --------WAVKLLTSFTIGFLFPVLST-------VYLVVP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSRLGLFIKKPFIKFI-------CH-------------TGSYLTFLFLLLL----- ----ASQHIAK------------------------------------------------- ------------------------------------------------------------ ----------------------------------------TDLHMQGPPPTIVEWLI-LP WVLGFIWAEIKEMWD--------------------------------------------- -----------------------------GGFNEY------IHDWWNLMDFAMNSLYLAT ISL-KIVAYVK-------------------YNGSR----------PRQEWEMWHPTLIAE AFFAIANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET--------------------SASEEPNN--CKGIRCEKQ-NNA-FST--LFET LQSLFWSIFGL---------------LNLY--------------------VTNVKARH-- ---------------------------------------------------------EFT EFVGATMFGTYNIISLVVLLNMLIAMMNNSYKLIADHADI------------EW------ ---KFARTKLWMSYFDE---GATLPPPF----------NIIPS----------------- ---------------------------------------------------PKCIWYLVK WLHAQA---------------------------------CPKRC------SEDEQKKHEN LREF---------------------------------------TERHADD---------- ---------------------------LIQNQHYQE--VIKN------------------ ----------------LVKRYVAAMIRSAKTDEGLTEEN---------------FK---- ----------------------------ELKQDISSFRYEVLDLL--------------- ----------------------------------GNRKSS-----RRTYST-SSDGVQMG -D---M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EEG GAE-ENKI---------------------------------------------------- ----------------------------------------------VSFSL--------- ----------------------------------------------AGE-ASD--K---- ------------------------------------------------------------ ------------------------------------------------------------ -------RLKMNSFRV-----------------------------------SALIKSVS- --------GIALSEDS--------------SKNNGLSKQSA----------------AVR NGNCFQ--------------GNKKDSFK-------------------------RLGLLFS RMNGQ---------------LA-----------------EPSPEPVAT------VSDGLV QAHG---------MWQDFKYSQ-------------------------------------- ------------------------------------------------------------ -ISSPGDVTR---------------------------------------------SEGSL D-----------AVGLVPQVIRKNGIDSHC-PAN-----RSD--SF--HCSS-------- --------------------------------------NNCASN-NKLIDSA-DDV---- ----YNSWGEAC------------DL----LMTSWKAGQEDYVTTQL------------- ----- >Callorhinchus:milii_elephant:fish_XP:007889426.1_NW:006890071.1_Vertebrata_TRPC1_TRPC4 ------------------------------------------------------------ ----------------------------------MAQL---------------------- ------------------------------------------------------------ ----------------------------------------------------YYKRSD-- ------------------------------------------------------------ ----NAPYRDRISLRIVRA----------------------------------------- --------------ESELSP-----------------------------AE--------- -----------KTY---------------------------------------------- ---------------LSAVEKGDYASVKK------------------------------- ------------------------------------ALE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EAEIYFKINI-------- ---------------------------NCIDPL--------------------------- ---GRT----ALLIAIE------------------------------------NENLEII ELLLSFN----------------------------------------------------- ------------------------------------------------------------ --------------------VYVGD-----------------------------ALLHAI RKEVVGAVELLLIHK--------KPRGEK------------------------------- ------------------------------------------------------------ -----QVPPIL------------------------------------------------- --------------------------------------LDKQFSEF-------------- ------TPDIT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------TNSYEIIKLLVQ------RGVSIPQPH------------- -----------------EVRCNCVECVSSSDVDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RLNIYRAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSEDP--------- -----FLTAFHLSWELQELSKVE-NEFK------------------SEYEELSQQCKTFA KDL---LDQTR-SSRE-------------------------------------LELILNY GDD-----------NC-ILE----E--------QKTNDLSRLKLAIK-----YHQKEFVA QPNCQQLLASRWYDEFPGWRRRH------------------------------------- --------WIVKFLTCIVIGLLFPGFSV-------CYLIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KSTLGLFIRKPFIKFI-------CH-------------TASYLTFLFLLLL----- ----ASQHIDR------------------------------------------------- ------------------------------------------------------------ ----------------------------------------TDLNMQGPSPTLVEWML-LP WVLGFIWGEIKQMWD--------------------------------------------- -----------------------------GGLQDY------IHDWWNLMDFVMNSLYLAT ISL-KIVAFIK-------------------YSGSR----------KREEWEMWHPTLVAE ALFAFANIFSSLRLISLF-TANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQ LYFYYET--------------------NASEEPNN--CKGIRCEKQ-NNA-FST--LFET LQSLFWSIFGL---------------INLY--------------------VTNVKARH-- ---------------------------------------------------------EFT EFVGTTMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI------------EW------ ---KFARTKLWMSYFEE---GGTLPTPF----------NIIAS----------------- ---------------------------------------------------PKSAWYLLK WLQRHL---------------------------------CPKKF------CKQERKKPES LGCL---------------------------------------GRRAANN---------- ---------------------------LKRNHQYQE--VIRN------------------ ----------------LVKRYVAAMIRDAKTEEGLTEEN---------------FK---- ----------------------------ELKQDISSFRYEVLGLLK-------------- ----------------------------------GSRPSS-----VQPSNI-STAPTKIS -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KNKV---------------------------------------------------- ----------------------------------------------FETKPESGT----- ---------------------------------------------VSTS-SSE--Q---- ------------------------------------------------------------ ------------------------------------------------------------ -------KNKLTFYEV-----------------------------------TSLLCPKSV --------PKRSGTET--------------ASTS-LSNGST----------------PKA TELCKE-----KQN----NKSIVKDSIK-------------------------NLGFFRK RTKLC---------------NT-----------------EQSMNRIYT------VSEEIT QEET---------LQKDTENADCR------------------------------------ ------------------------------------------S----------------- -KRDSEPVSD---------------------------------------------SGSGL K-----------HP----------RASKECNPEL-----EDSTHVLL-HRQSLESSAI-- -----------------R---LLESTQDVVTNVSGNKDSVCPVN-QW------------- ------------------------------TMT-----QDDYVTTRL------------- ----- >Callorhinchus:milii_elephant:fish_XP:007900054.1_NW:006890057.1_Vertebrata_TRPC1_TRPC6 ------------------------------------------------------------ ----------------------------------MCERRI-------------------- ----------------------------PRAGNH-------------------------- -----SATTSSPAPSNE---------------------------------REGYLMMG-- ---------------------YK--EGACP------PLSGHYSSR-------FNGDR--- PLRRQTM--QKGRRQAFRGPAY---------------MF--------------------- -----------TDRSTSLSA-----------------------------DE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EFG---SLNV-------- ---------------------------NCVDFM--------------------------- ---GQN----ALQLAVA------------------------------------NEHLEVI ELLLKRDN---------------------------------------------------- ------------------------------------------------------------ -------------------LSRVGD-----------------------------ALLLSI SKGYVRIVEALLSHHAFTAG--CRLTVSP------------------------------- ------------------------------------------------------------ -----SQQELQHD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SHDVT-------------PIILAAH----------------------------- ------------------------------------------------------------ --------------------CQEYEIVHILLR------KGTRIERPH------------- -----------------DYFCKCGECTEKQLHDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPVY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELAVLANIE-KEFK------------------NDYKKLSMQCKDFV VGL---LDLCR-NTEE-------------------------------------VEAILNG -NV-----------ETVHDS----NPY-------LRPSLSKLKLAIK-----YEVKKFVA HPNCQQQLLSIWYENLSGLRQQP------------------------------------- --------IAVKFLVVLGVAIGLPFLAM-------FYCIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGKIMRAPFMKFV-------AH-------------GASFTVFLGLLVMN---- ----AADRFDG-----------------------------TKLLPNESV-TDHPR----- ------------------------------------------------------------ ----------------------------------------QLFRMKTSCFTWMELLI-IS WVIGMIWSECKEIWS--------------------------------------------- -----------------------------QGPREY------LVELWNLLDFGMLAIFVAS FVA-RFMAYWHASKAQS--FVDEKI-KMDLVNATLSTEIEYYT-FARIKWLPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMLGMFN LYSYYLG------------------------------------AKQ-NDA-FTT--VEES FKTLFWAIFGL---------------SEVK--------------------SVVINYGH-- ---------------------------------------------------------KFI ENIGYVLYGVYNVTMVIVLLNMLIAMINSSYQEIEDDADV------------EW------ ---KFARAKLWISYFEE---GRTLPVPF----------NLVPS----------------- ---------------------------------------------------PKSIVYLLL KSKRLLAKLL----------------------------RCRKE----------ELHEDAE MDKL-------------------------------------------------------- --------GQSKPSSIRSSEDHSLNSISNPPTRYQK--IMKR------------------ ----------------LIKRYVLKAQIDKEN-DDVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQNTEELA -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIRQLG- ------------------------------------------------------------ ----------------------------------------------------EKLGA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007899534.1_NW:006890140.1_Vertebrata_TRPC1_TRPC7 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MHRRHTTLREKGRRQAIRGPAY---------------MF--------------------- -----------NERGTSLTP-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVVRK------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ESK---TLNF-------- ---------------------------NCVDYM--------------------------- ---GQN----ALQLAVG------------------------------------NEHLEVT ELLLKKEH---------------------------------------------------- ------------------------------------------------------------ -------------------LARIGD-----------------------------GLLLAI SKGYVRIVEAILNHSAFAQG--HRLAISP------------------------------- ------------------------------------------------------------ -----LEQELRDD----------------------------------------------- -------------------------------DFY---AYDEDGTRF-------------- ------SHDIT-------------PVILASH----------------------------- ------------------------------------------------------------ --------------------CQEYEIVHILLL------KGARIEKPH------------- -----------------DYFCKCSECSEKQKRDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RMNAYKGL-------------------------------------------- --------------------------------------ASAAY----------------- -------------------------------------------LSLSSEDP--------- -----VLTALELSNELARLANIE-TEFK------------------NDYRKLSMQCKDFA VGV---LDLCR-DTEE-------------------------------------VEAILNG -DV-----------DSMPQG----D----------RPCLSRVKLAIK-----YEVKKFVA HPNCQQQLLTIWYENLSGLRQQS------------------------------------- --------IAVKCLTVFGITVGLPFLAI-------GYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGQILRSPFMKFV-------AH-------------AVSFTIFLGLLVIN---- ----ASDRFEG-----------------------------IKHLPNETV-TDYPR----- ------------------------------------------------------------ ----------------------------------------QIFRVKTTTFTWTEMLI-MK WILGMIWTECKEMWM--------------------------------------------- -----------------------------EGPKEY------VMHLWNILDFGMLSIFVAS FTA-RLMAFLKASEAQR--YVDTYVNATDLSKALLPPHIAYFT-YARNKWFPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFN LYSYYLG------------------------------------AKF-NPA-FTT--VEES FKTLFWSIFGL---------------SEVI--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYILYGVYNVTMVVVLLNMLIAMINSSYQEIEEDADV------------EW------ ---KFARAKLWLSYFDE---GRTLPAPF----------NLVPS----------------- ---------------------------------------------------PKSAYYCGL KIKQCLIHLC----------------------------KTKVQ----------KSESDLE MGML---------------------------------------NSKQR-HRC-------- ------------QCNPRGSEGLGTRKPISNPTRYQR--IMKR------------------ ----------------LIKRYVLKAQVDRES-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEEK--------------- ----------------------------------------------------SQTTGELA -Q---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQQLS- ------------------------------------------------------------ ----------------------------------------------------DKFGKNMK K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007906461.1_NW:006890261.1_Vertebrata_TRPC1_TRPC3 ------------------------------------------------------------ ----------------------------------MSEEAKR------------------- ---------------------------QRRVSF--------------------------- ------------CEEEI---------------------------------RQKWKEEN-- ---------------------GDLGSHCHSLGPEDRDLHGHQSYTMQSV------SNPTV MQRRMTAMREKGRRQAIRGPAF---------------MF--------------------- -----------NDRGTSLSP-----------------------------EE--------- -----------ERF---------------------------------------------- ---------------LDAAEYGNIPVIRR------------------------------- ------------------------------------MLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ETK---TLNV-------- ---------------------------NCVDYM--------------------------- ---GQN----ALQLAVG------------------------------------NEHLEVT ELLLKRDN---------------------------------------------------- ------------------------------------------------------------ -------------------LARIGD-----------------------------ALLLAI SKGYIRIVEAILNHSAFIHS--KRLTLSP------------------------------- ------------------------------------------------------------ -----CEQELQDD----------------------------------------------- -------------------------------DFY---SYDEDGTRF-------------- ------SPDIT-------------PIILASH----------------------------- ------------------------------------------------------------ --------------------CQKYEVVHMLLM------KGARIERPH------------- -----------------DYFCKCNECVEKQKNDSFSHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYKGL-------------------------------------------- --------------------------------------ASPAY----------------- -------------------------------------------LSLSSEDP--------- -----VHTALELSNELAKLANIE-KEFKLKNKKVEMVKGPHIVTSSNDYRKLSMQCKDFV VGV---LDLCR-DTEE-------------------------------------VEAILNG -DV-----------EAEQED----GQH------CHRAGLTRVKLAIK-----YEVKKFVA HPNCQQQLLTIWYENLSGLREQP------------------------------------- --------IAMKCLVVLVVAIGIPFFAI-------GYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CSKLGKILRSPFMKFV-------MH-------------AASFIIFLCLLVFN---- ----ASDRFEG-----------------------------IKTLPNVTV-TDYPK----- ------------------------------------------------------------ ----------------------------------------QVFRMKTTMFTWTEMLI-MV WVLGMMWSECKEIWI--------------------------------------------- -----------------------------EGPREY------IFQMWNVLDFGMLSIFIAA FTA-RFMAFLEASKAQQ--YVDEHVQESDLSLVTLPPEIEYFT-YARDKWVPSDPQIISE GLYAIAVVLSFSRIAYIL-PANESFGPLQISLGRTV-KDIFKFMVIFIMVFLAFMIGMFI LYSYYLG------------------------------------AKV-NPA-FTT--VEES FKTLFWSIFGL---------------SEVS--------------------SVVLKYDH-- ---------------------------------------------------------KFI ENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDADV------------EW------ ---KFARSKLWLSYFDH---GKTLPPPF----------SLVPS----------------- ---------------------------------------------------PKSCINLII RIKNCLLALF----------------------------KCKRK----------RFKKDVE IGMM---------------------------------------NSKSRLNLF-------- -----------TQSNLRISETQSFNSIINQPTRYQQ--IMKR------------------ ----------------LIKRYVLKAQVDKEN-DEVNEGE---------------LK---- ----------------------------EIKQDISSLRYELLEDK--------------- ----------------------------------------------------SQATEELA -F---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LIQKLG- ------------------------------------------------------------ ----------------------------------------------------EKLNTCLT KTKTTVT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007910239.1_NW:006890714.1_Vertebrata_TRPC1_TRPC2 ------------------------------------------------------------ ----------------------------------MDSLTQ-------------------- ------------------------------------------------------------ --------------------------------------------------------DN-- ------------------------------------------------------------ ------------------------------------------------------------ --------------WREIAN-----------------------------KK--------- -----------MKFPPS------------------------------------------- --------------LITAIYDGNLAKVYK------------------------------- ------------------------------------LLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TSD--------G------ ---------------------ILRQLDDTEDRS--------------------------- ---WRE----ALNLAIR------------------------------------MSNEDIM TALLRCVKF--------------------------------------------------- ------------------------------------------------------------ ------------------DFRQIHE-----------------------------ALLVAV DTNQVRVVKLLLE----------RLDQEK------------------------------- ------------------------------------------------------------ -----GTSHNKVDI---------------------------------------------- --------------------------MSFSLALF---DHSIDSSRF-------------- ------APGVT-------------PLTLACQ----------------------------- ------------------------------------------------------------ --------------------KNLFEIVDLLMK------KGHIIATPH------------- -----------------KISCSCPECLNARQYDMLKFSLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RMNTYKGL-------------------------------------------- --------------------------------------ASRPY----------------- -------------------------------------------LSIANEDA--------- -----MLSAFKLSRELKQLSKKE-PEFK------------------PEYLTLEDLCQDLA VEL---LGMCR-NQSE-------------------------------------VTAVLND CGDD----------NADELD----NQA----FEEGIPDLARLRLAVN-----YNQKRFVA HPICQQVLTSIWCGNLTWWRGSK------------------------------------- --------TIWKIFISTGTFITMPILCL-------IYWIAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KCKVGQIVRTPVIKFL-------LH-------------SSSYVWFLVFLIV----- ----ESILAQE------------------------------------------------- ------------------------------------------------------------ ----------------------------------------NRDIAASRKQPLQENSFHMI WVVGFFWYECKEVWI--------------------------------------------- -----------------------------EGLRSY------LLDWWNFLDVVILSMYLSS FAL-RLVVTVSGQLYCS--TNHSSL------------ECYYFTEADRHTWQQEDPQILAE VLFAITSMLSLARLTSIL-PAHETLGTLQISIGKMI-DDMMRFMFVLMIILTAFLCGINN IYVHYVD----------------------------------------LDR-LGN--FNGT LQFLFWSMFGMEEPK----------SVDLS--------------------QFMVA----- ------------------------------------------------------------ EVVGRVLYGIFTIVMVIVLLNMLVAMITNSFQKIEDDADV------------EW------ ---KFARSRLYLCYFRE---GLTLPVPF----------NIIPT----------------- ---------------------------------------------------PKCLFYLLR WILRGL---------------------------------CC----------IKSAKQ--D YPPL---------------------------------------PT--------------- -SI--------PNVPMQSDNFRA----EKRASYRLQ--VIST------------------ ----------------LVHRYIEQSRQEFAEKQRKDLGN--------------RIT---- ----------------------------DLSTFVGRLQSEIKHLR--------------- ----------------------------------QSMAS-------------GGSAGKSN -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ASSVLGK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------YILGAR- ------------------------------------------------------------ --------------------NRFQDPEP------------------------ESVSNSDS GSRKT--------------------------------------------SFKITVHQ--- ------------------------------------------------------------ ------------------------------------------------------------ ---DCAEEQIA---------------------------------------AATGESDDDS S--------DQTDQ-GLG------------------------------------------ ---------------------------------------TDQSS-PS------SDTAFPT E---ECSEEEK------------------------------------------------- ----- >Homo:sapiens_Human_ENSG00000134160_Chr15_TRPM1_Vertebrata_TRPM1 ------------------------------------------------------------ ---------------------------------M--GQKS-------------------- -------------------------------------------------------W---- -------IEKTFCKRECIFVIPSMKDSN-------------------------------- -----------RCCCGQFTNQHIPPLPSATPSKNEE-ESKQV--------------ETQP EKWSVAKHTQSYPTDSY---------------------------GVLEFQGGGYSN---- -------------KAMYIRV-----------------------------S-------YDT -KPDSLLHLMVKDWQLE--------------------LPKLLISVHGGLQNFEM------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- GGVSTG------------------------------------------------------ ----VISHVGDALKDHS--------------------SKSRGRVCAIGIAPWGIVENKED LVGK-----DVTRVYQTMSNP--------------------------------------- ---LSKLSVLNNSHTHFILADN----------------GTLGKYGAEVKLRR-------- ---------------------------LLEKHI--------------------------- ---SLQ------KINTRL-------------------------------GQG----VPLV GLVVEGGPN--------------------------------------------------- VVSIVLEYLQEEP----------------------------------------------- ------------PIP---------------------------------------VVICDG SGRASDILSFAHK-----------YCEEG-------------GIINE-SLREQLLVTIQ- ---KTF-N---------------------------------------------------- --------YNKAQ----SHQLFAIIMECMKKK--------------------ELVTVFRM --------------------------GSEGQQ-----DIEM-----AILTALLKG----- ------TNVSA----PD-------QLSLALAWNRVDIARS----------------QIFV FGPHWPPLGSLAPPTDSKATEKEKKPPMAT-TKGGRGKGKGKKK-GKVKEEVEEETDPRK IELLNWVNALEQAMLDALV-LDRVDFVKLLIE------NG-------------------- --------------------VNMQHFLTIPRLEELYNTRLG------------------- ------------------------------------------------PPN-TLHLLVRD VK----------------------KSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNF RTLYNNLFG----------------PKRPKALKLLGMEDDEP------------------ -PAKGKK-----KKKKKKEEEIDIDVDD----------PAVSRFQYPFHELMV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------AVFLWQRGEES--------- -----MAKALVACKLYKAMAHES-SESD------------LVDDISQDLDNNSKDFGQLA LEL---LDQSY-KHDE-----------------------------------QIAMKLLTY -------------------------------ELKNWSNSTCLKLAVA-----AKHRDFIA HTCSQMLLTDMWMGRLRMRKNPG------------------------------------- ------------LKVIMG-ILLPPTIL----------FLEF-RTYDDFSY---------- ------------------------------------QTSKENEDGKEKEEEN-------- ---------T---DANA-DAGSRKGD---------------------------------- ----EENE----------------HKKQRSIPI--------------------------- ----GTKICEFYNAPIVKFW-------FY-------------TISYLGYLLLFNY----- -----VILVRM---------------------------------------DGWP------ ------------------------------------------------------------ --------------------------------------------------SLQEWIV-IS YIVSLALEKIREILM--------------------------------------------- ----------SEPG------------KLSQKIKVW------LQEYWNITDLVAISTFMIG AIL-RLQNQ----------------PYMGYGRVIY------------------------- ---CVDIIFWYIRVLDIF-GVNKYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQA ILHPEEKPSWKL---------------------------------------A-----RNI FYMPYWMIYGEVFADQ----------IDLY----------------------AMEINPPC GENLYDEEGK--RLPP------------------------------CIPGA--------- -WLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHDR----PVLPPPM-------------------------------- ----------------------------------------------------IILSHIYI IIMRL----------------------------------SG-RCRKKREGDQEERDRGLK LFL----------------------------------------SDEELKR-L-------- -------------------------------HEFEE--QCVQEHFREKEDE-QQ-SSSDE -----------------------RIRVTSERVENMSMR----------------LEEINE --RET-----------------------FMKTSLQTVDLRLAQLE--------------- -----------------------------------ELS---------NRMVNALENLAGI -D-R-------------------------------------SDLIQARSRASSEC-EATY L---------------------------------------LRQS-----SINSADGYSLY RYHFNGEELLFEDTSLS----------------------TSPGTGVRKKTCSFRIKEEKD V-------------------------------------------KTHLVPECQNS----- -----------LHLSLGTS----------------------------------------- TSATPD---------------------------GSHLA--VDDLKNAEESKL-------- -------------------------------------GPDIGISKEDDE-R--------- QTDSKKEETI-----------------------------SPSLNKTDVIHG-----QDK- ------------------------------SDVQNTQLTVETTNIEGT------------ ----------------------------ISYPLEETKITRYFPDETINACKT--MKSR-S F--VY-----SRGR-------------------KLVG--GV-NQDVEYSSITDQ------ -QLT------TEW------QCQVQ------------------------------------ -----------KITRSHSTD---------------------IPY----------IVSEAA VQ-------------AEH-----------------------KEQFADMQDEHH------- ---------------------------------------------------------VAE AIPRIPRLSLTI------------------------------------------TDRNGM E-------NLLS------VKPDQTLGFPSLRSKSLHGHPRNV-KSIQGKLD--------- -----RSGHASS-----V------------------SSLVIV---SGM---------TAE EKKVKKE---------------------K-ASTETE-C---------------------- ----- >Homo:sapiens_Human_ENSG00000142185_Chr21_TRPM2_Vertebrata_TRPM2 -------------------------------------------------------MEPSA LRKAGSEQEEGFE-------GLPRRVTDLGMVSNLRRSNSSLFKS--------------- ---------------------WRLQCPFGNN----------------DKQESLSSW---- -------IPENIKKKECVYFVESSKLSDA------------------------------- --------GKVVCQCGYTHEQHLEEATKPHTF------------------------Q--G TQWDPKKHVQEMPTDAF---------------------------GDIVFTGLSQK----- -------------VKKYVRV-----------------------------S-------QDT -PSSVIYHLMTQHWGLD--------------------VPNLLISVTGGAKNFNM------ -----------KPRLKSIFRRGLVKVAQT------------------------------T GAW---------------------------------IIT--------------------- GGSHTG------------------------------------------------------ ----VMKQVGEAVRDFSLSS-----------------SYKEGELITIGVATWGTVHRREG LI---HPTGSFPAEYILDEDG--------------------------------------- ---QGNLTCLDSNHSHFILVDD----------------GTHGQYGVEIPLRT-------- ---------------------------RLEKFI--------------------------- ---SEQ------TKERG--------------------------------GVA--IKIPIV CVVLEGGPG--------------------------------------------------- TLHTIDNATTNG------------------------------------------------ -------------TP---------------------------------------CVVVEG SGRVADVIAQVAN-LPVS-----DITIS--------------------LIQQKLSVFFQ- ---EMFET---------------------------------------------------- --------FTESR----IVEWTKKIQDIVRRR--------------------QLLTVFRE --------------------------GKDGQQ-----DVDV-----AILQALLKA----- ------SRSQD----HFGHENWDHQLKLAVAWNRVDIARS----------------EIFM DEWQWK------------------------------------------------------ ------PSDLHPTMTAALI-SNKPEFVKLFLE------NG-------------------- --------------------VQLKEFVTWDTLLYLYENL--------------------- ------------------------------------------------DPSCLFHSKLQK VL-VEDPERPAC---------------APAAPRLQMHHVAQVLRELLGDFTQPLYPR--- ------------------------------------PRHND--RLRLLLPVPHVKL---- NVQGVSLRSLYKRSSGHVT-----------------------FTMDPIRDLLI------- -----WAIVQ----------------------------NRREL----------------- ----------------------------------------AGIIWAQSQDC--------- -----IAAALACSKILKELSKEE-EDT----------------DSSEEMLALAEEYEHRA IGV---FTECY-RKDE-----------------------------------ERAQKLLTR -------------------------------VSEAWGKTTCLQLALE-----AKDMKFVS HGGIQAFLTKVWWGQLSVDNGLW------------------------------------- -------------RVTLC-MLAFPLLLT--------GLISF-R----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EKRLQDVGT------------- ---PAARARAFFTAPVVVFH-------LN-------------ILSYFAFLCLFAY----- -----VLMVDF---------------------------------------QPVP------ ------------------------------------------------------------ --------------------------------------------------SWCECAI-YL WLFSLVCEEMRQLFY--------------------------------------------- ---------DPDEC------------GLMKKAALY------FSDFWNKLDVGAILLFVAG LTC-RLIPA-----------------TLYPGRVIL------------------------- ---SLDFILFCLRLMHIF-TISKTLGPKIIIVKRMMK-DVFFFLFLLAVWVVSFGVAKQA ILIHNERRVDWL---------------------------------------F-----RGA VYHSYLTIFGQIP-GY----------IDGV----------------------NFN-PEHC SPNGTDPY-----KPK------------------------------CPESDATQQRPAFP EWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQ------------IW------ ---KFQRHDLIEEYHGR----PAAPPPF-------------------------------- ----------------------------------------------------ILLSHLQL FIKRV----------------------------------VLKTPAKR--------HKQLK NKL----------------------------------------EKNEEAA-L-------- -------------------------------LSWEI--YLKENYLQNRQFQ-QK-QRPEQ -----------------------KIEDISNKVDAMVDL----------------LDLDPL -KRSG-----------------------SMEQRLASLEEQVAQTA--------------- -----------------------------------QAL---------HWIVRTLRASGF- -S-S-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EADVPTLASQKAAEEPDAEPGGRKK-------------------------------- -----------------------------TEEPGDSYHVNARHLLYPNCPVTRFPVPNE- ----------------KVPWETEFLI-----------YDPPFYTAERKD-AAA------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MDPMGDTLEPLSTIQYNV--------VDGLRDRRS FHGPYT---VQAGLP-----------------LNPMGRTGL----------------RGR GSLS----------------------------------CFG------PNHTLYPMVTRWR RNEDGA----ICRKSIK-----------------------------KMLEVL-VVKLPLS EHW---------ALPGGS-----------------------REPGE-------------- ----------------------------------------------------------ML PRKL--KRILRQEHWPSF--------------ENLLKCGMEVY-------KGYMDDPRNT D-------NAWIET-VAVSVHFQDQNDVELNRLN----------SNLHACDSG---AS-- ----IRWQVVDR-----R------------------IPLYAN---HKT------------ ------------L--------------LQ-KAAAEF-GAHY------------------- ----- >Homo:sapiens_Human_ENSG00000083067_Chr9_TRPM3_Vertebrata_TRPM3 MPEPWGTVYFL-GI-----------------------------AQVFSFLFSWWNLE--- ----GVMNQADAPRPLNWTIRKLCHAAFLPSVRLLKAQKS-------------------- -------------------------------------------------------W---- -------IERAFYKRECVHIIPSTKDPH-------------------------------- -----------RCCCGRLIGQHVGLTPSISVLQNEK-NESRL-----------SRNDIQS EKWSISKHTQLSPTDAF---------------------------GTIEFQGGGHSN---- -------------KAMYVRV-----------------------------S-------FDT -KPDLLLHLMTKEWQLE--------------------LPKLLISVHGGLQNFEL------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- GGVNTG------------------------------------------------------ ----VIRHVGDALKDHA--------------------SKSRGKICTIGIAPWGIVENQED LIGR-----DVVRPYQTMSNP--------------------------------------- ---MSKLTVLNSMHSHFILADN----------------GTTGKYGAEVKLRR-------- ---------------------------QLEKHI--------------------------- ---SLQ------KINTRI-------------------------------GQG----VPVV ALIVEGGPN--------------------------------------------------- VISIVLEYLRDTP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDILAFGHK-----------YSEEG-------------GLINE-SLRDQLLVTIQ- ---KTF-T---------------------------------------------------- --------YTRTQ----AQHLFIILMECMKKK--------------------ELITVFRM --------------------------GSEGHQ-----DIDL-----AILTALLKG----- ------ANASA----PD-------QLSLALAWNRVDIARS----------------QIFI YGQQWP------------------------------------------------------ ------VGSLEQAMLDALV-LDRVDFVKLLIE------NG-------------------- --------------------VSMHRFLTISRLEELYNTRHG------------------- ------------------------------------------------PSN-TLYHLVRD VKKREY----------PGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRF RTLYHNLFG----------------PKRPKALKLLGMEDDIP------------------ -LRRGR------KTTKKREEEVDIDLDD----------PEINHFPFPFHELMV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFFWQHGEEA--------- -----MAKALVACKLCKAMAHEA-SEND------------MVDDISQELNHNSRDFGQLA VEL---LDQSY-KQDE-----------------------------------QLAMKLLTY -------------------------------ELKNWSNATCLQLAVA-----AKHRDFIA HTCSQMLLTDMWMGRLRMRKNSG------------------------------------- ------------LKVILG-ILLPPSIL----------SLEF-KNKDDMPYMSQAQEIH-- --------------------------------LQEKEAEEPEKPTKEKEEEDM-E----- --------LTAMLGRNN-GESSRKKD---------------------------------- ----EEEV----------------QSKHRLIPL--------------------------- ----GRKIYEFYNAPIVKFW-------FY-------------TLAYIGYLMLFNY----- -----IVLVKM---------------------------------------ERWP------ ------------------------------------------------------------ --------------------------------------------------STQEWIV-IS YIFTLGIEKMREILM--------------------------------------------- ----------SEPG------------KLLQKVKVW------LQEYWNVTDLIAILLFSVG MIL-RLQDQ----------------PFRSDGRVIY------------------------- ---CVNIIYWYIRLLDIF-GVNKYLGPYVMMIGKMMI-DMMYFVIIMLVVLMSFGVARQA ILFPNEEPSWKL---------------------------------------A-----KNI FYMPYWMIYGEVFADQ----------ID-----------------------------PPC GQNETREDGKIIQLPP------------------------------CKTGA--------- -WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHER----PVLPPPL-------------------------------- ----------------------------------------------------IIFSHMTM IFQHL----------------------------------CC-RWRK-HESDPDERDYGLK LFI----------------------------------------TDDELKK-V-------- -------------------------------HDFEE--QCIEEYFREKDDR-FN-SSNDE -----------------------RIRVTSERVENMSMR----------------LEEVNE --REH-----------------------SMKASLQTVDIRLAQLE--------------- -----------------------------------DLI---------GRMATALERLTGL -E-R-------------------------------------AESNKIRSRTSSDCTDAAY I---------------------------------------VRQS-----SFNSQEGNT-F KLQESIDP-AGEETMSP----------------------TSPTLMPRMRSHSFYSVNMKD KG-------------------------G-------------IEKLESIFKERSLS----- -----------LHRATSSHSVA--KEPK---APAAP---------------------ANT LAIVPD---------------------------SRRPSSCIDIYVSAMDELH-------- ------------------------------------------------------CDIDPL DNSVNI----------------------LGLGEPSFSTPVPSTAPSSSAYATLA-PTDRP PSRSI-DFEDITSM--------DTRSFS--SDYTHLPECQNPWDSEPP------------ ----------------------------MYHTIERSKSSRYLATTPFLLEEAPIVKSH-S F--MFS---PSRS---------------------YYANFGVPVKTAEYTSITDCIDTR-- ------------------------------------------------------------ -----------CVNAPQAIADR------AAFPGGLGDKVEDLT------------CCHPE RE-------------AEL-----------------------SHPSSDSEEN--------- -----------------------------------------------------------E AKGRRATIAISS------------------------------------------QEGDNS E------RTLSNNI-T-VPKIERANSYSAEEPSAPYAHTRKS-FSISDKLD--------- -----RQRNTAS-----L------------------RNPFQR---SKS---------SKP EGRGDSL-----S--------------MR-RLSRTS-AFQSFE-SKHN------------ ----- >Homo:sapiens_Human_ENSG00000130529_Chr19_TRPM4_Vertebrata_TRPM4 ------------------------------------------------------------ ------------------------------MVVP-EKEQS-------------------- -------------------------------------------------------W---- -------IPKIFKKKTCTTFIVDS--TDP------------------------------- --------GGTLCQCGRPRTAHPAVAMEDAFG------------------------AAVV TVWDSDAHTTEKPTDAY---------------------------GELDFTGAGRK----- -------------HSNFLRL-----------------------------S-------DRT -DPAAVYSLVTRTWGFR--------------------APNLVVSVLGGSGGPVL------ -----------QTWLQDLLRRGLVRAAQS------------------------------T GAW---------------------------------IVT--------------------- GGLHTG------------------------------------------------------ ----IGRHVGVAVRDHQMAS-----------------TGG-TKVVAMGVAPWGVVRNRDT LI---NPKGSFPARYRWRGDP--------------------------------------- --EDGVQFPLDYNYSAFFLVDD----------------GTHGCLGGENRFRL-------- ---------------------------RLESYI--------------------------- ---SQQ------KTGVG--------------------------------GTG--IDIPVL LLLIDGDEK--------------------------------------------------- MLTRIENATQAQ------------------------------------------------ -------------LP---------------------------------------CLLVAG SGGAADCLAETLE-DT--------LAPGS-------------GGARQGEARDRIRRFFP- ---K-------------------------------------------------------- -----------GD----LEVLQAQVERIMTRK--------------------ELLTVY-S --------------------------SEDGSE-----EFET-----IVLKALVKA----- ------CG--S----SEASAYLD-ELRLAVAWNRVDIAQS----------------ELFR GDIQWR------------------------------------------------------ ------SFHLEASLMDALL-NDRPEFVRLLIS------HG-------------------- --------------------LSLGHFLTPMRLAQLYSAA--------------------- ------------------------------------------------PSNSLIRNLLDQ ASH-------------SAGTKAPA--LKGGAAELRPPDVGHVLRMLLGKMCAPRYPSG-- -----------------------------------GAWDPHPGQGFG------------- -----ESMYLLSDKATSPLS-L---DAGL--------------GQAPWSDLLL------- -----WALLL----------------------------NRAQM----------------- ----------------------------------------AMYFWEMGSNA--------- -----VSSALGACLLLRVMARLE-PDA----------------EEAARRKDLAFKFEGMG VDL---FGECY-RSSE-----------------------------------VRAARLLLR -------------------------------RCPLWGDATCLQLAMQ-----ADARAFFA QDGVQSLLTQKWWGDMASTTPIW------------------------------------- -------------ALVLA-FFCPPLIYT--------RLITF-RKSEEEPTRE-------- ----------------------------------ELE-FDMDSVIN------------GE ------GPVGTADPAEK-TPLGVPRQS--------------------------------- ---GRPGCCG-G-----------RCGGRR---C--------------------------- ----LRRWFHFWGAPVTIFM-------GN-------------VVSYLLFLLLFSR----- -----VLLVDF---------------------------------------QPAP------ ------------------------------------------------------------ -------------------------------------------------PGSLELLL-YF WAFTLLCEELRQGLSGGGGSLASG------------------------------------ -------GPGPGHA------------SLSQRLRLY------LADSWNQCDLVALTCFLLG VGC-RLTPG-----------------LYHLGRTVL------------------------- ---CIDFMVFTVRLLHIF-TVNKQLGPKIVIVSKMMK-DVFFFLFFLGVWLVAYGVATEG LLRPRDSDFPSI---------------------------------------L-----RRV FYRPYLQIFGQIPQED----------MDVA----------------------LME-HSNC SSEPGFWA-----HPP---------GAQAG---------------TCVSQ--------YA NWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDL------------YW------ ---KAQRYRLIREFHSR----PALAPPF-------------------------------- ----------------------------------------------------IVISHLRL LLRQL----------------------------------CRRPRSPQP---SSPALEHFR VYL----------------------------------------SKEAERK-L-------- -------------------------------LTWES--VHKENFLLARARD-KR-ESDSE -----------------------RLKRTSQKVDLALKQ----------------LGHIRE -----------------------------YEQRLKVLEREVQQCS--------------- -----------------------------------RVL---------GWVAEALSRSALL -P-P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---GGPPP----PDLPGSKD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000070985_Chr11_TRPM5_Vertebrata_TRPM5 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MQDVQGPRP------------------------------- ------------------------------------------------------------ ----------GSPGDAEDRRELG------------------LHRGEVNFGGSGKK----- -------------RGKFVRV-----------------------------P-------SGV -APSVLFDLLLAEWHLP--------------------APNLVVSLVGEEQPFAM------ -----------KSWLRDVLRKGLVKAAQS------------------------------T GAW---------------------------------ILT--------------------- SALRVG------------------------------------------------------ ----LARHVGQAVRDHSLAS-----------------TSTKVRVVAVGMASLGRVLHRRI LE---EAQEDFPVHYPEDDGG--------------------------------------- --SQGPLCSLDSNLSHFILVEP----------------GPPGKGDGLTELRL-------- ---------------------------RLEKHI--------------------------- ---SEQ------RAGYG--------------------------------GTG-SIEIPVL CLLVNGDPN--------------------------------------------------- TLERISRAVEQA------------------------------------------------ -------------AP---------------------------------------WLILVG SGGIADVLAALVN-QPH------LLVPK--------------------VAEKQFKEKFP- ---SK--H---------------------------------------------------- --------FSWED----IVRWTKLLQNITSHQ--------------------HLLTVYDF --------------------------EQEGSE-----ELDT-----VILKALVKA----- ------CKSHS----QEPQDYLD-ELKLAVAWDRVDIAKS----------------EIFN GDVEWK------------------------------------------------------ ------SCDLEEVMVDALV-SNKPEFVRLFVD------NG-------------------- --------------------ADVADFLTYGRLQELYRSV--------------------- ------------------------------------------------SRKSLLFDLLQR KQEEAR-------LTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFY----- -------------------------------------QDGRPGD---------------- -------RRRAEKGPAKRPT-------GQKWLL-----DLNQKSENPWRDLFL------- -----WAVLQ----------------------------NRHEM----------------- ----------------------------------------ATYFWAMGQEG--------- -----VAAALAACKILKEMSHLE-TEA----------------EAARATRE--AKYERLA LDL---FSECY-SNSE-----------------------------------ARAFALLVR -------------------------------RNRCWSKTTCLHLATE-----ADAKAFFA HDGVQAFLTRIWWGDMAAGTPIL------------------------------------- -------------RLLGA-FLCPALVYT--------NLITF-SEEAPLR-TGLEDLQ--- ----------------------------------DLDSLDTEKSPLYGLQSR-------- ------------VEELV-EAPRAQGD---------------------------------- -------------------------RGPRAVFL--------------------------- ----LTRWRKFWGAPVTVFL-------GN-------------VVMYFAFLFLFTY----- -----VLLVDF---------------------------------------RPPP------ ------------------------------------------------------------ -----------------------------------------------QGPSGPEVTL-YF WVFTLVLEEIRQGFF--------------------------------------------- ---------TDEDT------------HLVKKFTLY------VGDNWNKCDMVAIFLFIVG VTC-RMLPS-----------------AFEAGRTVL------------------------- ---AMDFMVFTLRLIHIF-AIHKQLGPKIIVVERMMK-DVFFFLFFLSVWLVAYGVTTQA LLHPHDGRLEWI---------------------------------------F-----RRV LYRPYLQIFGQIPLDE----------IDEA----------------------RV----NC STH--PLLLE--DSPS------------------------------CPSL--------YA NWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADM------------FW------ ---KFQRYNLIVEYHER----PALAPPF-------------------------------- ----------------------------------------------------ILLSHLSL TLRRV----------------------------------FKKEAEHK--------REHLE RDL----------------------------------------PDPLDQK-V-------- -------------------------------VTWET--VQKENFLSKMEKR-RR-DSEGE -----------------------VLRKTAHRVDFIAKY----------------LGGLRE -----------------------------QEKRIKCLESQINYCS--------------- -----------------------------------VLV---------SSVADVLAQGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GPRSSQH----------------------------------------------- ------------------------------------------------------------ -------------------------------------------CGEGSQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LVAADHRGG L-------DGWEQP-GA----GQPPSDT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000119121_Chr9_TRPM6_Vertebrata_TRPM6 ------------------------------------------------------------ -----------MKEQ--------------PVLERLQSQKS-------------------- -------------------------------------------------------W---- -------IKGVFDKRECSTIIPSSKNPHRCTPVCQVC----------------------- -------QNLIRCYCGRLIGDHAGIDYSWTISAAK---------------------GKES EQWSVEKHTTKSPTDTF---------------------------GTINFQDGEHTH---- -------------HAKYIRT-----------------------------S-------YDT -KLDHLLHLMLKEWKME--------------------LPKLVISVHGGIQNFTM------ -----------PSKFKEIFSQGLVKAAET------------------------------T GAW---------------------------------IIT--------------------- EGINTG------------------------------------------------------ ----VSKHVGDALKSHS--------------------SHSLRKIWTVGIPPWGVIENQRD LIGK-----DVVCLYQTLDNP--------------------------------------- ---LSKLTTLNSMHSHFILSDD----------------GTVGKYGNEMKLRR-------- ---------------------------NLEKYL--------------------------- ---SLQ------KIHCRS-------------------------------RQG----VPVV GLVVEGGPN--------------------------------------------------- VILSVWETVKDKD----------------------------------------------- --------------P---------------------------------------VVVCEG TGRAADLLAFTHK-----------HLADE-------------GMLRP-QVKEEIICMIQ- ---NTF-N---------------------------------------------------- --------FSLKQ----SKHLFQILMECMVHR--------------------DCITIFDA --------------------------DSEEQQ-----DLDL-----AILTALLKG----- ------TNLSA----SE-------QLNLAMAWDRVDIAKK----------------HILI YEQHWK------------------------------------------------------ ------PDALEQAMSDALV-MDRVDFVKLLIE------YG-------------------- --------------------VNLHRFLTIPRLEELYNTKQG------------------- ------------------------------------------------PTNTLLHHLVQD VK----------------------QHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHF RALYNNLY-----------------RKYKHQRHSSGNRNESAEST------LHSQFIRTA QPYKFKEKSIVLHKSRKKSKEQNV-SDD----------PESTGFLYPYNDLLV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------AMFFWQHGEEA--------- -----TVKAVIACILYRAMAHEA-KESH------------MVDDASEELKNYSKQFGQLA LDL---LEKAF-KQNE-----------------------------------RMAMTLLTY -------------------------------ELRNWSNSTCLKLAVS-----GGLRPFVS HTCTQMLLTDMWMGRLKMRKNSW------------------------------------- ------------LKIIIS-IILPPTIL----------TLEF-KSKAEMSHVP-------- ------------------------------------QSQDF-QFMWYYSDQNA-SSSKES ------ASVKEYDLERG-HD--EKLD---------------------------------- ----ENQHF--G-----------LESGHQHLPW--------------------------- ----TRKVYEFYSAPIVKFW-------FY-------------TMAYLAFLMLFTY----- -----TVLVEM---------------------------------------QPQP------ ------------------------------------------------------------ --------------------------------------------------SVQEWLV-SI YIFTNAIEVVREICI--------------------------------------------- ----------SEPG------------KFTQKVKVW------ISEYWNLTETVAIGLFSAG FVL-RWGDP----------------PFHTAGRLIY------------------------- ---CIDIIFWFSRLLDFF-AVNQHAGPYVTMIAKMTA-NMFYIVIIMAIVLLSFGVARKA ILSPKEPPSWSL---------------------------------------A-----RDI VFEPYWMIYGEVYAGE----------ID------------------------------VC SSQ-----------PS------------------------------CPPGS--------- -FLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNN------------LW------ ---KYNRYRYIMTYHEK----PWLPPPL-------------------------------- ----------------------------------------------------ILLSHVGL LLRRL----------------------------------CCHRAPH----DQEEGDVGLK LYL----------------------------------------SKEDLKK-L-------- -------------------------------HDFEE--QCVEKYFHEKMED-VN-CSCEE -----------------------RIRVTSERVTEMYFQ----------------LKEMNE --KVS-----------------------FIKDSLLSLDSQVGHLQ--------------- -----------------------------------DLS---------ALTVDTLKVLSAV -D-TLQEDEALLAKRKH-STCKKLPHSWSNVICAEVLGSMEIAGEKKYQYYSMPSSLLRS LAGGRH-------------PPRVQRG-----ALLE-----ITNSKREATNVRN------D QERQETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATE QDIQTEVLVHLTGQTPVVSDWASVDEPKEK-----------HEPIAHLLDGQDKA----- ---EQVLP--TLSCTPEPMTMSSPLSQAKIMQTGGGYVNWAFSEGDETGVFSIKKKWQTC LPSTCDSDSS---RSE-------------QHQKQAQDSSLSDNSTRSAQSSECSEVG-PW -----LQPN-------TSFW------INPLRRYRPFARSHSFRFHKEEK-LMKICKIKNL SGSSEIGQGA-----WVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQL----NP EPGENSISEEEYSKNWFTV---SKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQED LSKNSLWNSRSTNLNRNSLLKSSIGVDKISASLKSPQEPHHHYSA---IERNNLMRLSQT I--PFTPVQLFAGEEITVYRLEESSPLNLDKSMSSWSQRGR-AAMIQVLSREEM-----D GGLRKAMRVVSTW-----SEDDILK-PG---------QVFI------VKSFLPEVVRTWH KIFQESTVLHLCLREIQQQRAA-----QKLIYTFNQVKPQTIPYTPRFLEVF-LIYCHSA NQWL----TIEKYMTGEF-----------------------RKYNNNNGDE--------- ----------------------------------------------------------IT PTNTLEELMLAFSHW--------------------------TYEYTR--GELLVLDLQGV G-------ENLTDP-SVIKPEVKQSRGMVFGPANLGEDAIRN-FIAKHHCNS----CC-- ----RKLKLPDL-----K------------------RNDYSP---ERINSTFGLEIKIES AEEPPAR-----E--------------TG-RNSPED-DMQL------------------- ----- >Homo:sapiens_Human_ENSG00000092439_Chr15_TRPM7_Vertebrata_TRPM7 ------------------------------------------------------------ ---------------------------------M--SQKS-------------------- -------------------------------------------------------W---- -------IESTLTKRECVYIIPSSKDPHRCLPGCQIC----------------------- -------QQLVRCFCGRLVKQHACFTASLAMKYSDV-KLGDH-----------F--NQAI EEWSVEKHTEQSPTDAY---------------------------GVINFQGGSHSY---- -------------RAKYVRL-----------------------------S-------YDT -KPEVILQLLLKEWQME--------------------LPKLVISVHGGMQKFEL------ -----------HPRIKQLLGKGLIKAAVT------------------------------T GAW---------------------------------ILT--------------------- GGVNTG------------------------------------------------------ ----VAKHVGDALKEHA--------------------SRSSRKICTIGIAPWGVIENRND LVGR-----DVVAPYQTLLNP--------------------------------------- ---LSKLNVLNNLHSHFILVDD----------------GTVGKYGAEVRLRR-------- ---------------------------ELEKTI--------------------------- ---NQQ------RIHARI-------------------------------GQG----VPVV ALIFEGGPN--------------------------------------------------- VILTVLEYLQESP----------------------------------------------- ------------PVP---------------------------------------VVVCEG TGRAADLLAYIHK-----------QTEEG-------------GNLPD-AAEPDIISTIK- ---KTF-N---------------------------------------------------- --------FGQNE----ALHLFQTLMECMKRK--------------------ELITVFHI --------------------------GSDEHQ-----DIDV-----AILTALLKG----- ------TNASA----FD-------QLILTLAWDRVDIAKN----------------HVFV YGQQWL------------------------------------------------------ ------VGSLEQAMLDALV-MDRVAFVKLLIE------NG-------------------- --------------------VSMHKFLTIPRLEELYNTKQG------------------- ------------------------------------------------PTNPMLFHLVRD VK----------------------QGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRF RLIYNSLGGNN--RRSGRNTSSST-PQLRKSHESFGNRADKKEKMR------HNHFIKTA QPYRPKIDTVMEEGKKKRTKDEIVDIDD----------PETKRFPYPLNELLI------- -----WACLM----------------------------KRQVM----------------- ----------------------------------------ARFLWQHGEES--------- -----MAKALVACKIYRSMAYEA-KQSD------------LVDDTSEELKQYSNDFGQLA VEL---LEQSF-RQDE-----------------------------------TMAMKLLTY -------------------------------ELKNWSNSTCLKLAVS-----SRLRPFVA HTCTQMLLSDMWMGRLNMRKNSW------------------------------------- ------------YKVILS-ILVPPAIL----------LLEY-KTKAEMSHIP-------- ------------------------------------QSQDAHQMTMDDSENNF-QNITEE ------IPMEVFKEVRI-LDSNEGKN---------------------------------- ----EMEI----------------QMKSKKLPI--------------------------- ----TRKFYAFYHAPIVKFW-------FN-------------TLAYLGFLMLYTF----- -----VVLVQM---------------------------------------EQLP------ ------------------------------------------------------------ --------------------------------------------------SVQEWIV-IA YIFTYAIEKVREIFM--------------------------------------------- ----------SEAG------------KVNQKIKVW------FSDYFNISDTIAIISFFIG FGL-RFGAKWNF-------ANAYDNHVFVAGRLIY------------------------- ---CLNIIFWYVRLLDFL-AVNQQAGPYVMMIGKMVA-NMFYIVVIMALVLLSFGVPRKA ILYPHEAPSWTL---------------------------------------A-----KDI VFHPYWMIFGEVYAYE----------ID------------------------------VC ANDS---V----IPQI------------------------------CGPGT--------- -WLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNI------------VW------ ---KYQRYHFIMAYHEK----PVLPPPL-------------------------------- ----------------------------------------------------IILSHIVS LFCCI----------------------------------CK-R-RK-----KDKTSDGPK LFL----------------------------------------TEEDQKK-L-------- -------------------------------HDFEE--QCVEMYFNEKDDK-FH-SGSEE -----------------------RIRVTFERVEQMCIQ----------------IKEVGD --RVN-----------------------YIKRSLQSLDSQIGHLQ--------------- -----------------------------------DLS---------ALTVDTLKTLTAQ -K-A-------------------------------------SEASKVHNEITRELSISKH LAQ----------------------------NLID--DGPVRPSVWKKHGVVNTLSSSLP QGDLESNNPFHCNILMKDDKDP---------QCNI----FGQDLPAVPQRKEFNFPEAGS SSG------ALFPSAVSPPELRQRLH-G-------------VELLKIFNKNQKLGS---- --SSTSIP--HLSSPPTKFFVSTPSQPS---CKSH------------------------- LETGTKDQETVCSKA------------------TEGDNTEFGAFVGHRDSMDLQR----- -------------------------------------------FKETSN-KI------KI LSNNNTSEN--------TLKRVSSLAGFTDCHRT-----SIPVHSKQAEKISR-----RP STED--THEVDSKAALIPDWLQDRP--------SNREMPSEEGTLNG------------- ----------------------------LTSPFKPAMDTNYYYSA---VERNNLMRLSQS I--PFTP-VPPRGEPVTVYRLEESSPNILNNSMSSWSQLGL-CAKIEFLSKEEM-----G GGLRRAVKVQCTW-----SEHDILK-SG---------HLYI------IKSFLPEVVNTWS SIYKEDTVLHLCLREIQQQRAA-----QKLTFAFNQMKPKSIPYSPRFLEVF-LLYCHSA GQWF----AVEECMTGEF-----------------------RKYNNNNGDE--------- ----------------------------------------------------------II PTNTLEEIMLAFSHW--------------------------TYEYTR--GELLVLDLQGV G-------ENLTDP-SVIKAEEKRSCDMVFGPANLGEDAIKN-FRAKHHCNS----CC-- ----RKLKLPDL-----K------------------RNDYTP---DKI---------IFP QDEPSDLNLQPGN--------------ST-KESESTNSVRLML----------------- ----- >Homo:sapiens_Human_ENSG00000144481_Chr2_TRPM8_Vertebrata_TRPM8 ------------------------------------------------------------ ---------MSFRAARLS--MRNRRNDTLDSTRTLYSSAS-------------------- ---------------------------RSTDLS--------------YSESDLVNF---- -------IQANFKKRECVFFTKDSK----------------------------------- -------ATENVCKCGYAQSQH---MEGTQIN------------------------Q--S EKWNYKKHTKEFPTDAF---------------------------GDIQFETLGKK----- --------------GKYIRL-----------------------------S-------CDT -DAEILYELLTQHWHLK--------------------TPNLVISVTGGAKNFAL------ -----------KPRMRKIFSR-LIYIAQS------------------------------K GAW---------------------------------ILT--------------------- GGTHYG------------------------------------------------------ ----LMKYIGEVVRDNTISR-----------------SSEE-NIVAIGIAAWGMVSNRDT LIRNCDAEGYFLAQYLMDDFT--------------------------------------- ---RDPLYILDNNHTHLLLVDN----------------GCHGHPTVEAKLRN-------- ---------------------------QLEKYI--------------------------- ---SER------TIQDS--------------------------------NYG--GKIPIV CFAQGGGKE--------------------------------------------------- TLKAINTSIKNK------------------------------------------------ -------------IP---------------------------------------CVVVEG SGQIADVIASLVEVEDA-------LTSS--------------------AVKEKLVRFLP- ---RTVSR---------------------------------------------------- --------LPEEE----TESWIKWLKEILECS--------------------HLLTVIKM --------------------------EEAGDE-----IVSN-----AISYALYKA----- ------FSTSE----Q-DKDNWNGQLKLLLEWNQLDLAND----------------EIFT NDRRWE------------------------------------------------------ ------SADLQEVMFTALI-KDRPKFVRLFLE------NG-------------------- --------------------LNLRKFLTHDVLTELFSN---------------------- ------------------------------------------------------------ --------------------------HFSTLVYRNLQIAKNSYNDALLTFVWKLVAN--- -------------------------------------------------------F---- RRGFRKEDRNGRDEMDIELHDVSP------------------ITRHPLQALFI------- -----WAILQ----------------------------NKKEL----------------- ----------------------------------------SKVIWEQTRGC--------- -----TLAALGASKLLKTLAKVK-NDI----------------NAAGESEELANEYETRA VEL---FTECY-SSDE-----------------------------------DLAEQLLVY -------------------------------SCEAWGGSNCLELAVE-----ATDQHFIA QPGVQNFLSKQWYGEISRDTKNW------------------------------------- -------------KIILC-LFIIPLVGC--------GFVSF-RK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----KPV------------------DKHKKLLW--------------------------- ------YYVAFFTSPFVVFS-------WN-------------VVFYIAFLLLFAY----- -----VLLMDF---------------------------------------HSVP------ ------------------------------------------------------------ --------------------------------------------------HPPELVL-YS LVFVLFCDEVRQW----------------------------------------------- ---------------------------YVNGV-NY------FTDLWNVMDTLGLFYFIAG IVF-RLHSS--------------NKSSLYSGRVIF------------------------- ---CLDYIIFTLRLIHIF-TVSRNLGPKIIMLQRMLI-DVFFFLFLFAVWMVAFGVARQG ILRQNEQRWRWI---------------------------------------F-----RSV IYEPYLAMFGQVP-SD----------VDGT----------------------TYD-FAHC TFTGNES------KPL------------------------------CVELD-EHNLPRFP EWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQ------------VW------ ---KFQRYFLVQEYCSR----LNIPFPF-------------------------------- ----------------------------------------------------IVFAYFYM VVKKC----------------------------------FKCCCKEK--------NMESS VCC----------------------------------------FKNEDNE-T-------- -------------------------------LAWEG--VMKENYLVKINTK-AN-DTSEE ------------------------------------------------------------ -----------------------------MRHRFRQLDTKLNDLK--------------- -----------------------------------GLL---------KEIANKIK----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014348116.1_NW:005819026.1_TRPM1_TRPM1_Vertebrata_TRPM1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M----------------- ----------------------------------------ALFLWQRGEEA--------- -----MAKALVACKLYKSMAHES-SESD------------LVDDISQDLDNNSKEFAQLA VEL---LDQSY-KHDE-----------------------------------QVAMKLLTY -------------------------------ELKNWSNSTCLKLAVA-----AKHRDFIA HTCSQMLLTDMWMGQLRMRKNPG------------------------------------- ------------LKVILG-ILLPPTIL----------FLEF-RTNDDISY---------- ------------------------------------QRSRGHEEGKDKEDENA------- -------------DGNA-DTCSRKGD---------------------------------- ----EEDG----------------DEKQRSIPI--------------------------- ----GTKIYEFYNAPIVKFW-------FY-------------TIAYLAYLMLFNY----- -----VILVKM---------------------------------------ERWP------ ------------------------------------------------------------ --------------------------------------------------TVQEWIV-IS YILTLAIEKIREILM--------------------------------------------- ----------SEPG------------KISQKVKVW------LQEYWNITDLVAICVFAIG LTL-RLQNQ----------------PYMGYGRVIY------------------------- ---CVDIIFWYIRVLDIF-GVNKYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQA ILHPDEEPSWRL---------------------------------------A-----RNI FYMPYWMIYGEVFADQ----------IDL------------------------------C ------ADGK--RLPP------------------------------CIPGA--------- -WLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHDR----PVLPPPM-------------------------------- ----------------------------------------------------IIFSHLSI ICSRV----------------------------------CC-RCKKRQEGEMDERDRGLK LVL----------------------------------------SDEELKK-L-------- -------------------------------YEFEE--QCVEEYFQEKEDQ-QL-SSNGE -----------------------RIRVTSERLRN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SG-----------------------------------SS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014345762.1_NW:005819512.1_TRPM2_TRPM1_Vertebrata_TRPM2 ------------------------------------------------------------ ------------------------------MLAVLRED---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------VCVCGYPRKGHSEIALSHNFL------------------------Q--D EKWDKQKHTVEISTDAF---------------------------GDITFIGLGQK----- -------------VGKYVRV-----------------------------S-------TET -HPHILYELMTKHWGLN--------------------IPNLLISVTGGAKNFSM------ -----------KPRLKDIFRRGLIKAAQS------------------------------T GAW---------------------------------IIT--------------------- GGSNAG------------------------------------------------------ ----VMKHVGKAIRDYTMGS-----------------CSKDGKIVAIGIATWGTVYNRES LL---SKEEKFPAEYVLDDEN--------------------------------------- ---QGRLSCLDNNHSHFILVDD----------------GTHGNYGVEIPLRT-------- ---------------------------KLEEFI--------------------------- ---SNQ------TLKKK--------------------------------GVG--IKIPVV CVVLEGGPG--------------------------------------------------- TLDTIHNAITNG------------------------------------------------ -------------TP---------------------------------------CVIVEG SGRIADVIAHVAN-LPIS-----KITIS--------------------LIQKQLKIFFT- ---EEFDK---------------------------------------------------- --------FTQEK----IIEWTKKIQDIVRMQ--------------------QLLTVFRV --------------------------DKEGQQ-----DIDI-----AILRALLKA----- ------SKSHE----YPGHEDWDHQLKLAVAWNRVDIAKS----------------EIFT GEKQWK------------------------------------------------------ ------SSDLHEVMTAALI-GDKPEFAKLFMD------QG-------------------- --------------------VSLKEYLNQKTLISLYNNL--------------------- ------------------------------------------------SPSSLIYNKILK LM-EEKPQQPML----------------PEQHMIQLYHISDILRELLGEFTELLYPR--- ------------------------------------PKDME--KNFGPLSAPQIRL---- NTLHTELSQPDHRKSSISTKND-------------------GVPEDPVRDLFL------- -----WAILQ----------------------------DRKEL----------------- ----------------------------------------SDMFWEQSRDC--------- -----IAAALGASKILKKLSSEE-EDT----------------DRSEEMQALADEYEERA IRV---FTECY-RKDD-----------------------------------ERSEKLLTR -------------------------------ISEAWGKTTCLRLALE-----ADNKTFLA QGGVQAFLTKVWWGKLSVDTKRW------------------------------------- -------------QLMLC-MLLFPLIFT--------GLITF-RN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----QP-------------------KSS------SKGQELKLKQMNC------------- ----GERLKGFFSSPVVIFY-------WN-------------VLSYFGFLWLFAY----- -----VIMVDF---------------------------------------QTTP------ ------------------------------------------------------------ --------------------------------------------------SWKECLL-YF WIASLVSEEIRQLVY--------------------------------------------- ---------DPDGL------------GHYKKSTIY------IKDFWNKMDVFAILVFIIG LIC-RLMTR-----------------TVYEGRIIL------------------------- ---SLDFIIFCLRLIHIF-TVSKTLGPKIIIVKKMMK-DVFFFLFLLAVWLVAYGVAKQA ILIHNEERLDWI---------------------------------------F-----RGV VYQSYLTVFGEIP-SD----------IDGT----------------------TFD-LESC TVNGTDPY-----KPK------------------------------CQEH--RNGLPIFP DWLTILLMCVYLLFANILLLNLLIAMLSYTFEQIQENTDK------------IW------ ---MFQRHDLIEEYHGR----PAAPPPF-------------------------------- ----------------------------------------------------IIFNHIYL FVKHF----------------------------------ILCRPPRR--------RKQFK EKL----------------------------------------PKNEDAE-L-------- -------------------------------LSWEA--FMKENFLANLQHE-VN-QSTDQ -----------------------KIRDTSEKVNMMVEV----------------LEINQK -NTDG-----------------------TIQQRLANLEEQLFQSA--------------- -----------------------------------KAL---------NWIMTVLSEKGF- -G-P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KDTAPLLTTEKLKETESKKADSEVK-------------------------------- -----------------------------VEDQKSKYHVNARILLYPGSSVKCFPVPDE- ----------------KVLWKVEFQG-----------YAPPFYTSEKVR-VPG------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KPVN---------------EQLRE--- ---------------------------------NPMGRTGL----------------QGK GVLY----------------------------------WFG------VNHAIDPVITRWR RKVDGS----VKVKELK-----------------------------RMLEFL-AVSCPSS KHW---------ALPG-------------------------------------------- ------------------------------------------------------------ -----------------------------------------IY-------RGYVDDSRNT D-------NAWIET-QAINVHFENTDDLIVAKLN----------SKCSKED-----GP-- ----VRWQPIEQ-----N------------------ISIYAN---QKD------------ ------------F--------------LQ-KVAELH-DAHY------------------- ----- >Latimeria:chalumnae_Coelacanth_XP:014347481.1_NW:005819759.1_TRPM3_TRPM1_Vertebrata_TRPM3 ------------------------------------------------------------ ------MSQTDAPRPLNWTIRKLCHAAFLPSVRLLKAQKS-------------------- -------------------------------------------------------W---- -------IERAFYKRECVHIITSIKDPH-------------------------------- -----------RCCCGRLIGQHVGLPPSISITNNEK-NEGRL-----------SRHDTLA EKWSISKHTQLSPTDAF---------------------------GTIEFQGGGHSN---- -------------KAMYVRV-----------------------------S-------YDT -KPDLILHLMTKEWILE--------------------LPKLLISVHGGLQNFEL------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- GGVNTG------------------------------------------------------ ----VIRHVGDALKDHA--------------------SKSRGKICTIGIAPWGIVENQED LIGK-----DVVRPYQTMSNP--------------------------------------- ---LSKLTVLNSMHSHFILADN----------------GTTGKYGAEVKLRR-------- ---------------------------QLEKHI--------------------------- ---SLQ------KINTRI-------------------------------GQG----VPVV ALIVEGGPN--------------------------------------------------- VISIVLEYLRDTP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDILAFGHK-----------YSEEG-------------GLINE-SLRDQLLVTIQ- ---KTF-N---------------------------------------------------- --------YSRTQ----AQHLFIILMECMKKK--------------------ELITVFRM --------------------------GSEGHQ-----DIDL-----AILTALLKG----- ------ANASA----PD-------QLSLALAWNRVDIARS----------------QIFI YGQQWP------------------------------------------------------ ------VGSLEQAMLDALV-LDRVDFVKLLIE------NG-------------------- --------------------VSMHRFLTISRLEELYNTRHG------------------- ------------------------------------------------PSN-TLYHLVRD VK----------------------KGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRF RTLYHNLFG----------------PKRPKALKLLGME---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VILG-ILIPPSIL----------SLEF-KYKDEMSYLPQGQEDQ-- --------------------------------LNEKEPEEPEKPAKEKEEDDM-E----- --------FTAMLGRRN-RESRRKKD---------------------------------- ----EEEG----------------PSRHRLIPF--------------------------- ----GRKIYEFYNAPIVKFW-------FH-------------TLAYIGYLMLFNY----- -----IVLVKM---------------------------------------ERWP------ ------------------------------------------------------------ --------------------------------------------------SVQEWIV-IS YIFTLGIEKMREILM--------------------------------------------- ----------SEPG------------KLLQKVKVW------LQEYWNVTDLMAILLFSIG MVL-RLQET----------------S-RSYGRVIY------------------------- ---CVNIIYWYIRLLDIF-GVNKYLGPYVMMIGKMMI-DMMYFVIIMLVVLMSFGVARQA ILNPSEDPSWKL---------------------------------------A-----KNI FYMPYWMIYGEVFADQ----------ID-----------------------------PPC GQNITGEDGKVIQLPP------------------------------CKTGA--------- -WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHER----PVLPPPL-------------------------------- ----------------------------------------------------IIFSHMTM VCQHL----------------------------------CC-RWRK-HEGDQEDRDYGLK LFI----------------------------------------TEDELKK-V-------- -------------------------------HDFEE--QCIEEYFREKEDH-FN-SSNDE -----------------------RIRVTSERVENMAMR----------------LEEVNE --REH-----------------------FMKASLQTVDIRLTQLE--------------- -----------------------------------ETI---------GRMASIMERLSGV -D-K-------------------------------------GEVTKIRSRASSDCTDTAY I---------------------------------------MRQS-----SFNSQEGNA-Y KLPETTDP-IGEEIMSP----------------------TSPTLMPRLRSHSFYAMGAKD KG-------------------------G-------------LEGLEGFFKERPVS----- -----------LHRATSSQSVTAARETK---ATSQP---------------------AKI LPVNQD---------------------------PKKLSSCIDIFVSTSDEMQ-------- ---------------------------------------TATEAAEKSL-KV------PV VRDQSFHSEI-----------------------------MAAVLASQAHSTGAG-PVGKY PDGNG-VFEETTTT--------DTPMLR--SGSTHFIDSQSQWDIDPP------------ ----------------------------SYQILERSKSSRYLATTSFF-DDTSMVKSH-S F--MFS---PTRG---------------------YFSNLGVPVKTAEYTSITDCIDTR-- ------------------------------------------------------------ -----------CVTASQTSSEH------STSPGNHGGKAEDMV------------ISHPE RE-------------AEL-----------------------SHPSSDNEEHE-------- ----------------------------------------------------------GE ARDRHEDGSLSS------------------------------------------QNANSN R-------PVSNNI-S-VPKMERANSYSAEEPNMLYAYTKKS-YSISDKLDT-------- -----RQRNLTG-----M------------------RNPFQR---SKS---------AKP EGKSESL-----S--------------MR-RLSKTA-AFRSFE-SKHN------------ --YT- >Latimeria:chalumnae_Coelacanth_XP:005990988.1_NW:005819093.1_LOC102365897_TRPM1_Vertebrata_TRPM4a ------------------------------------------------------------ ------------------------------MVDKIQKDGS-------------------- -------------------------------------------------------W---- -------IPKIVKKRVCNTFIEESRGADS------------------------------- --------GETLCQCGNPKNTHTTIATEDNFA------------------------AAMV SSWSMALHTQEKPTDAF---------------------------GDIEFAGAGKK----- -------------HNKFLRL-----------------------------S-------CDT -DPAIIYHFLTSHWKIP--------------------PPNLVVSVVGGDEHFKV------ -----------KNWLKDIVRKGLVKATQS------------------------------T GAW---------------------------------IIT--------------------- RGLRFG------------------------------------------------------ ----IGKYVGEAVRDHSTAN-----------------TSSRTKIVALGIAPWGIIHNRDC LV---NPKGSFPATYYMED----------------------------------------- --MGGPTFSLDNNYSAFLLVDD----------------GRTGHSGGEMHFQT-------- ---------------------------QLEKFI--------------------------- ---SKQ------KTGVG--------------------------------GKG-SIEIPVL CMLIAGDES--------------------------------------------------- MLERVCAVTKNM------------------------------------------------ -------------IP---------------------------------------WLVLAG SGGAADLLAEVLE-----------ASPTA-------------ESLRE-VVEKKVKKFFP- ---Q-------------------------------------------------------- -----------KD----LHRLVDLVEKIVQNK--------------------DLLTVY-T --------------------------DQEGME-----EFDN-----VILKALVKA----- ------CKSQT----GNSVEYLD-ELKLAVAWNRVDIAKS----------------ELFQ GDIYWK------------------------------------------------------ ------SNDLEDTMTDALI-NNKPEFVKLFVD------NG-------------------- --------------------LNIVEYLTYQRLEELYSSV--------------------- ------------------------------------------------AENSLLHYLL-R RVLQRN------------PEPQPHAPLSK-GREFSVYMVSKVLKDFLGGVCEPFY----- ------------------------------------------ADLVG------------- -----VYKTQSSKKDSKY---L---LTGAAENS-----YENKKSSCPWADLFI------- -----WAILQ----------------------------NRDEM----------------- ----------------------------------------AAYFWEMGGES--------- -----VTSALAACLILKEMSHVE-DEA----------------ESSHNMKKLAAKFEQLA VDV---FSECY-NNSE-----------------------------------SRAFTLLVR -------------------------------RSPIWGRATCLQLANV-----AGARNFFA QDGVQSLLTQIWWGELDRSTEVW------------------------------------- -------------KFLLT-FFCPPLMYT--------TLIKF-RDKEEDIKRENHHASP-- ---------------------------------LELESFDGDTKYSLRDLAIG-D--WGK ------GDMYLKNLDNI-SDINTWTR---------------------------------- ----EPGSSK-V-----------HEARRSQLFV--------------------------- ----VKRWKQFWYAPVASFL-------GN-------------LVMYFAFLLLFSY----- -----VLLIDF---------------------------------------KGAPP----- ------------------------------------------------------------ -----------------------------------------------KGPSNVEFLL-YF WVFTLAMEEIRQSMF--------------------------------------------- ----------VGNL------------PLRINLNQY------LKDVWNKCDIIAILLFLLG LIF-RMFPA-----------------TYASGRTVL------------------------- ---CLDFMVFALRLIHIF-AVHKELGPKIVIVGKMMK-DVFFFLFFLGVWLMAYGVTTQG LLHPNDHRLEWI---------------------------------------F-----RRV FYRPYLHIFGQIPLEE----------IDAA----------------------HFP-SSNC TDE------G--EGPP------------------------------CTNT--------YA NWLVLILLVIYLLVANILLVNLLIAMFSYTFTKVMDKSDI------------HW------ ---KFQRYNLIVEYHSR----PALAPPF-------------------------------- ----------------------------------------------------IILSHIHL LIKRN----------------------------------IRKVKSVK--------SKHFM LDL----------------------------------------SEARDSK-L-------- -------------------------------MTWEA--IQKENYVVNQNKV-KR-ESDTE -----------------------RLKRMSQKVDNILTN----------------MSEIRE -----------------------------HDRRLQVLESELDYCT--------------- -----------------------------------SAI---------SWMVESLDQSNLI -K-S-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SRPPPTVEDFVSSGQKQV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014344856.1_NW:005819406.1_TRPM5_TRPM1_Vertebrata_TRPM5 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MKRRVSKASEAFQKLNPVWKSNIISINTKLRIF----------RSNVL SV--LLYGGEKSCQC--------DHTTDEQI-------------------------TPVQ ESAARESRQNGQGNEEAAKRKQF------------------YSTREIEFLGSGKK----- -------------HGRFVKV-----------------------------S-------SST -HPACIFNLLINEWNLL--------------------APNLVVSMVGGEEQFQM------ -----------KSWLRDAIRKGLVKAAQS------------------------------T GAW---------------------------------ILT--------------------- SGLRVG------------------------------------------------------ ----ITKLVGEAVRDHSLAS-----------------TSSKTRVIALGIADLGVVKEKEV FM---NAKIDDPVYYKTDESG--------------------------------------- ---QGPMYSIDNNHSHFILVEE----------------NPDEPDTATTELRL-------- ---------------------------NLEKHI--------------------------- ---SEQ------RTGYG--------------------------------GTG-SIEIPVL CLLAHGRPN--------------------------------------------------- ILERMYQGMKNS------------------------------------------------ -------------AP---------------------------------------WLMLEG SGGIADILCSLMS-EP--------VVPE--------------------AVEKQLQEKFP- ---RN--D---------------------------------------------------- --------FIWED----ILTWTELIKNIVAQQ--------------------HLLTVHDL --------------------------EQEGSE-----ELDT-----VILKALVKA----- ------CKSQS----QEAQEYLD-ELKLAVAWNRVDIAKS----------------EIFN GDVEWR------------------------------------------------------ ------SCDLKEVMVDALV-NDKPDFVKLFID------NG-------------------- --------------------MNMHDFLTYGRLQELYCSI--------------------- ------------------------------------------------SQKCLLYELLMK KLEEHR-------LTLAGLNSQPHKDVLDKKPRFTLNEVSKVLKDFLHDACKGFY----- -------------------------------------QGPKQGGIKI------------- -----LVSYTADRNSKPRLN------VQRSLCL-------DQKCENPWRDLFL------- -----WAVLQ----------------------------NRQEM----------------- ----------------------------------------AYYFWTMCQEG--------- -----TAAALAACKILKEMARLE-SEA----------------ETARSMKE--AKYEHFA LEL---FNECY-ANSE-----------------------------------DRAFTLLVR -------------------------------KTKFWSKATCLHLATE-----ADAKIFFA HDGVQALLTKIWWGDMSKDTYIW------------------------------------- -------------KLVCG-FCFPPLIYT--------NLIMF-SDYEQQSGNGADQLK--- ----------------------------------ELDSLDTERALLLTELENK------- ---------YVQKEEET-LESSSGR----------------------------------- ---------------------------VSGAFL--------------------------- ----FTRWKKFWNAPVTVFL-------GN-------------VIMYFAFLFLFTY----- -----VLLLDF---------------------------------------KAPPV----- ------------------------------------------------------------ -----------------------------------------------DGPSVTEIIL-YF WVFTLVLEEIRQSFF--------------------------------------------- ---------IDEDI------------TLLKKFKLY------VEDSWNKCDMVAILLFIIG VTC-RMMNS-----------------TFEAGRTIL------------------------- ---AVDFMVFALRLIHIF-AIHKQLGPKIIIVERMMK-DVFFFLFFLSVWLFAYGVATQA LMHPNETRVTWI---------------------------------------F-----RRV LYRPYLHIFGQIRLDE----------IDAV----------------------RMQ-AQNC TNNPQDIWDE--TAPP------------------------------CPNL--------YS NWLVILLLVIFLLVTNVLLMNLLIAMFSYTFQVVQGNTDI------------FW------ ---KFQRYNLIVEYHNR----PALAPPF-------------------------------- ----------------------------------------------------IIFSHISL MVGRI----------------------------------FKKT-EHK--------KEHLE RNL----------------------------------------AEGLDQK-L-------- -------------------------------VTWET--VQKENYLANLEKG-KR-ESSEE -----------------------RLKKTSNKVDSLFNF----------------MNGFRQ -----------------------------QEKRLLSIETRMKYCT--------------- -----------------------------------DAL---------SWMVESFSENNL- -K-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ARPPPMFPSSLTCGNKKSEEIPAQV-------------------------------- --------------------------------------------------------PD-- -------------------------------------------CTQK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DTEMKYI D-------D--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014349563.1_NW:005820190.1_TRPM6_TRPM1_Vertebrata_TRPM6 -------------------------------------------------------MT--- --------KESFQFQEY-------------------PSKS-------------------- -------------------------------------------------------W---- -------TEGVFCKRECIKIIPSTKDPHRCFPGCQVC----------------------- -------QNLIRCCCGRLGWEHPGLNYGLPTYLSAQ--------------------ASEN EKWSIEKHTQTSPTDAY---------------------------GTIDFQDGAHSF---- -------------HAKYIRL-----------------------------S-------YDT -KMDQLLHLMVKEWQME--------------------LPKLVVSVHGGIQDFEL------ -----------PSKVKQVFGKGLMKAAET------------------------------T GAW---------------------------------IVT--------------------- EGINTG------------------------------------------------------ ----ISRHVGDALKAHV--------------------SQCLKKICAVGIPPWGVIQNQRD LMGK-----DVICQYQTLGNP--------------------------------------- ---LSKLNSLNSMHSHFILVDD----------------GTAGKYGNEMKLRR-------- ---------------------------KLEEYV--------------------------- ---SLQ------KIHTRM-------------------------------GQG----VPVV GLVVEGGPN--------------------------------------------------- VILTVWEYVRGTP----------------------------------------------- ------------PVP---------------------------------------VVVYEG TGRAADILAFTHK-----------HTSDE-------------GDLGA-ELKDKVLLMIQ- ---KTF-N---------------------------------------------------- --------FGQKQ----SNHLFKILMECMEHR--------------------ESITIFEA --------------------------DSEEQQ-----DIDL-----AILTALLKG----- ------TNASA----SD-------QLSLTLAWNRVDIAKK----------------HVLV HGQHWK------------------------------------------------------ ------VDCLEQAMLDALV-MDRVDFVKLLID------SG-------------------- --------------------VNIHHFLTISRLEELYNTKQG------------------- ------------------------------------------------PTNLLLHHLVWD VK----------------------QSNFPPGYKITMIDIGLVIENLLGGAYQSSYTRKHF RVLYNRLYRISTAKQSVTSFTSSFSRHSFHQIRQLDSEDNSL----------HSQFIRTA QPYEHKEKSVSFPKSRKKSKAMYSVSED----------QECAGFIYPFNDLLV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------AMFFWQHGEEA--------- -----MAKAVVAFKLYRAMAHEA-KQSN------------MVDDTSEELKKYSKEFGQLA VDI---LDCAF-KQNE-----------------------------------RMTMKLLTY -------------------------------ELKNWSQLTCLKLAVS-----SALRPFVS HTCTQMLLTDMWMGCLNMRKNSC------------------------------------- ------------FKVILS-ILLPPTIL----------MLEF-KSKAEMSHIP-------- ------------------------------------QSQEFHQFAQQYIDQYQ-PSGKEE GN----------------EDSEKGPE---------------------------------- ----QVENFA-------------IGRRERELTW--------------------------- ----TRKLCEFYNAPIVKFW-------FH-------------TIVYLFFLMLFTY----- -----TVLVKM---------------------------------------EPQP------ ------------------------------------------------------------ --------------------------------------------------IVQEWLV-II YIFTTAIENVREVFM--------------------------------------------- ----------SEPA------------KFTQKIKIW------FSEYWNLTESLAIVLFAIG FGL-RWVEP----------------PLRTAGRIIY------------------------- ---YLDIIFWFVRLLDFF-AVNQHAGPYLMMIGKMTA-NMFYIVIMMAIVLLSFGVSRKA ILSPEEPPSWTL---------------------------------------A-----RDI VFQPYWMIFGEVYAGE----------ID------------------------------AC ATDVN-----------------------------------------CPPGS--------- -FLTPFLQAVYLFVQYIILVNLLIAFFNNVYFDMKSISSN------------LW------ ---KYNRYRYIMAYHEK----PWLPPPF-------------------------------- ----------------------------------------------------IILSHIAL LIRQG----------------------------------YRYRMQK----DLEKGDVGLK LYL----------------------------------------SIEELKK-L-------- -------------------------------HDFEE--QCVEKYFHEKNET-FH-SSDTE -----------------------RIRVTTERVEEMFLQ----------------LKEVSE --KVL-----------------------YIKDSLLSLDSQLGHIQ--------------- -----------------------------------DLS---------ALTVDTLKVISAV -D-SLKVKEALLGDKRH-FAHQKLPHSWSYGIYSNPLDQFLDNMEKKYNYYSMPPSLFRN LAMAQQDHQSY-----------LTAGETEFSEAADCCSGHAIQKDAEGHTVMSELSCD-P KLLQNHEQ---HHMVTPHLQC----------QAFCKRVQLNISLPNTPSVTTSSALATKT IKNSCSIPVQLQFEKVDLSENNTDKYPGEHW--------DAILQVSSESDDKKAD----- --KHLVIP---QSTVVNKTSLMLDCSSK---EGVGGYLNLAFCDGDEPGIF------NEG LKRQRKQGTH-------------------TVYSTNSSSRHVQILTSSSSSHQSSPNSDSW GSTSRQQCNM------ASFW------IDPI-------SKDCWSFQKANNNRSH--GDEKL WSTCKIKDNLDR------------------------------------------------ ------------------------------SSYLPQKLKITESNGSTRHSSNFLRQSFED LGDGLLWNGRMGYLKKNSLVRSSNAVDRISASLETSQDLNQHYSA---VERNNLMRLTQN I--PFTPIQLIAGEEVSLYRLEESSPRNLDKSVSSWSQQGL-AAIIQVLSREEM-----G GGLRRAMKVICTW-----SEGNVLK-AG---------EVYI------VKSFLNEVVKTWQ KIFGDGTVLHLCLREIQQQRAA-----QKLIYTFNQIKPQTIPYTPRFLEVF-LLCCHSA DQWL----TIEKCINGEF-----------------------QKYNNNNGDE--------- ----------------------------------------------------------IT PANLLEEMMLAFSHW--------------------------TYEYTR--GELLVLDLQGV G-------ENLTDP-SVIKPENKQSRGMAFGPANLGEEAIKN-FTAKHHCNS----CC-- ----RKLRLLDL-----K------------------RNAFTP---SKTNPA--------- ---------------------------FD-DESSET-NTRL------------------- ----- >Latimeria:chalumnae_Coelacanth_XP:014340312.1_NW:005819057.1_TRPM7_TRPM1_Vertebrata_TRPM7 ------------------------------------------------------------ ---------------------------------M--SQKS-------------------- -------------------------------------------------------W---- -------TESNFTKRECVFIIPVSKDPHRCLPGCQIC----------------------- -------QQLVRCCCGRLVRQHVGFTASLAMKYSDV-KLGED-----------I--NSEL ETWSVEKHTEESPTDAY---------------------------GIINFQGGSHSY---- -------------RAKYLRL-----------------------------S-------YDA -KPEDILCLMLKEWQMD--------------------LPKLVISVHGGMQNFEL------ -----------LPRIKQVVGKGLVKAAIT------------------------------T GAW---------------------------------ILT--------------------- GGVNTG------------------------------------------------------ ----VAKHVGDALKEHA--------------------SSLPRKICTIGIAPWGVIENRND LIGK-----DVVVPYQNLLNP--------------------------------------- ---LSKLNVLNNHHSHFLLVDD----------------GTVGKYGAEVNLRR-------- ---------------------------KLEKHV--------------------------- ---NLQ------RIHARI-------------------------------GQG----VPVV ALIFEGGPN--------------------------------------------------- VILTVLEYLQESP----------------------------------------------- ------------PVP---------------------------------------VVVCEG TGRAADILAYIHK-----------QTEEG-------------GRLTD-GVEDEIISTIK- ---KTF-N---------------------------------------------------- --------FSQNE----AIHLFQTLMECMKNK--------------------ELITVFHI --------------------------GSEEHQ-----DIDV-----AILTALLKG----- ------SNACA----FD-------QLVLTLAWDRVDIAKN----------------HVFV YGQQWL------------------------------------------------------ ------VGSLEQAMLDALV-MDRVEFVKLLIE------NG-------------------- --------------------VSMHKFLTIPRLEELYNTKQG------------------- ------------------------------------------------PINPALFHLVRD VK----------------------QGNLTADYKITLIDMGLVIEFLMGGTYRCTYTKKRF RIIYNNLHGNN--RRPGRHCSTTNVPQLRKNHDSFSNRADKKEKMR------HNHFIKTA QPYKPKLDATVEQGKKKRCKDEVVDIDD----------PEMRRFPYPFNELLV------- -----WSVLM----------------------------KRQKM----------------- ----------------------------------------ALFFWQHGEES--------- -----MAKALVACKLYRSMAYEA-KQSD------------VVDDASEELKQCSSEFGQLA VDL---LEQAF-RQDE-----------------------------------TMAMKLLTY -------------------------------ELKNWSNSTCLKLAVS-----SRLRPFVA HTCTQMLLSDMWMGRLNMRKNSW------------------------------------- ------------YKVILS-ILVPPAIL----------LLEY-KTKAEMSHIP-------- ------------------------------------QSQDAHQMTMEDSEQNF-QNPVDE ------IPMDVFKEVRI-LDISDAKH---------------------------------- ----EVET----------------PARERRIPI--------------------------- ----IRKFYAFYHAPIVKFW-------FN-------------TLAYLGFLMLYTF----- -----VVLVKM---------------------------------------QTAP------ ------------------------------------------------------------ --------------------------------------------------SAQEWIV-IA YIFTSAIEKIREIFM--------------------------------------------- ----------SEAG------------KINQKVKVW------FSDYFNISDTVAIITFFVG FGL-RFGVA----------------DVFVAGRITY------------------------- ---CLNIIFWYVRLLDFL-AVNQQAGPYVMMISKMVA-NMFYIVVIMAVVLLSFGVPRKA ILYPEEEPSWML---------------------------------------A-----RDI VFQPYWMIFGEVYAYE----------ID------------------------------VC ANNS--EE----KPDL------------------------------CGVGT--------- -WLTPFLQAVYLFVQYILMVNLLIAFFNNVYFQVKAISNI------------VW------ ---KYQRYHFVMAYHEK----PVLPPPL-------------------------------- ----------------------------------------------------IILSHLAS LCSCI----------------------------------CR-R-RK-----KDKTPDGPK LFL----------------------------------------TEEDQKK-L-------- -------------------------------HDFEE--QCVEIYFHERDDK-FH-SGSEE -----------------------RIRVTSEKVENMCIQ----------------LKEVGD --RVN-----------------------YIKRSLHSLDSQIGHLQ--------------- -----------------------------------DLS---------ALTVDTLKTLTAQ -K-A-------------------------------------SEASKVHNEITRELSISKH LGQ----------------------------STIE--GGLLRSSMRKKHSIGTLLGSSFP QGGADTNTSPLGNVATEDCQD-----------INIRNDTFGLEIIAAPEREELNIPEAGT SGS------ALLPSVVSPTKLQRKDHLM-------------LEKPHYFAEDQMLGN---- --SPNIIP--NLSFPTAKFFVSSPSEPS---CTSH------------------------- LGPATDQVDS--SKAI---------------ADADSHNIEFGAFVGHRDSMEIQR----- -------------------------------------------LKEVTS-QF------K- --ETKIAEAVGGLHTDCALRMVNSYAGLTELHKH-----SSSNQPQSLHGTNT-----RA SSEDV-VHQEDSKTSLLP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ITW----------------------------------------------- ------------------------------------------------------------ ---------------GGY-----------------------SKY---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TIKLLQ----------------- ----- >Latimeria:chalumnae_Coelacanth_XP:014348370.1_NW:005819026.1_LOC106704876_TRPM1_Vertebrata_TRPM1:like ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MYIRV-----------------------------S-------YDT -KPDVLLHLMIKDWQLE--------------------LPKLLISVHGGLQNFDL------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- GGVSTG------------------------------------------------------ ----VIRHVGDALKDHS--------------------SKSRGKIYAIGIAPWGIVENRED LIGK-----DITRPYQTMSNP--------------------------------------- ---LSKLCVLNNTHTHFILADN----------------GTTGKYGAEVKLRR-------- ---------------------------QVEKHI--------------------------- ---SLQ------KINTRL-------------------------------GQG----VPVV GLIVEGGPN--------------------------------------------------- VISIVLECLREEP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDILSFAHK-----------YSEEG-------------G----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014339893.1_NW:005828667.1_LOC106702253_TRPM1_Vertebrata_TRPM3:like:partial ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFFWQHGEEA--------- -----MAKALVACKLCKAMAHEA-SEND------------MVDDISQELNHNSRDFGQLA VEL---LDQSY-KQDE-----------------------------------QLAMKLLTY -------------------------------ELKNWSNATCLQLAVA-----AKHRDFIA HTCSQMLLTDMWMGRLRMRKNSG------------------------------------- ------------FK---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014345846.1_NW:005819518.1_TRPM8_TRPM1_Vertebrata_TRPM8 -------------------------------------------------------MG--- --------EEEIGSCKRL--IKTDQHYNMDTLQT-------------------------- ------------------------------------------------RKAALCKF---- -------IEENFKKRKCVYFLPDPQ----------------------------------- -------KGEGMCKCGYLKSSHNELCEGEQ--------------------------D--T EKWTSQKHTVQVPTDAY---------------------------GDVVFDELGQR----- --------------GKYVRL-----------------------------A-------SDT -NPEILYELMTKYWRLK--------------------TPNLIISVTGGAKNLPL------ -----------KAPMRKIFSR-LIYIARS------------------------------Q GAW---------------------------------IFT--------------------- AGTNHG------------------------------------------------------ ----VMRHIGEVVRDHTLSK-----------------NSEE-KIVTIGIAAWGMIHNRES LIRKPETQGYYTAHYVLDKEN--------------------------------------- ---RGSQYCLDNNHSHLILVDN----------------GSHAHYTVEQKIRT-------- ---------------------------NLETYI--------------------------- ---SEN------VTTGS--------------------------------D-G--AKIPII CFAQEGGKG--------------------------------------------------- TLQSIHHAVKSN------------------------------------------------ -------------IP---------------------------------------CVIVRG TGRVADVIASFVG-EDAT-----EISSS--------------------TMKEKIEKYLY- ---PLFMK---------------------------------------------------- --------LSEKD----KQTWTHWFEEVLEKP--------------------HLLTVINM --------------------------EDANDE-----IVTE-----AISLALFKA----- ------YREGD----NLGKRTWHSQMKILLEWNQAELARK----------------ELFQ VGQEWQ------------------------------------------------------ ------LSDLKDLMYTALI-KNKPDFVRLFLE------NG-------------------- --------------------FGLKRFASPTTLTKLYTK---------------------- ------------------------------------------------------------ --------------------------HFRGQDSFKLHKAKKSSDDSLLEMVWKMIKH--- -------------------------------------------------------F---- QSVESKLQEN-REESALHISE-SP--------------EASLVSRHPIQTLFL------- -----WAVLQ----------------------------KKKEL----------------- ----------------------------------------SFAIWEKIGGC--------- -----TMAALGAAKILRKLAQKE-EDD----------------NISEELKSFADDYETCA IDV---FAESY-NDDE-----------------------------------EMATKLLVQ -------------------------------PCDFWDNSSCLVLAAH-----GNAKQFVA ITPVQTFLSKKWHGEISEETRTW------------------------------------- -------------KILLC-MLFFPLIFC--------GLITF-SK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----EPA------------------MKERKTLLPA------------------------- ----QRYFTAFFTSPFVIFC-------WN-------------VLSYLAFLLLFAY----- -----VLLVDY---------------------------------------QLIP------ ------------------------------------------------------------ --------------------------------------------------SWPEYLL-YF WVFTLFCEEIRQLCS--------------------------------------------- ----------RSDQ------------GIMNKISNY------LDDFWNMMDVMALVWFMVA LLY-RLIPS--------------TMYTPYVGKVFF------------------------- ---CIDYIIFTLRLIHIF-TANRYIGPKIIMVQKMMI-DVFFFLFLFAVWMIAYGVAKQG MMRHNEHRLDQL---------------------------------------L-----RSV VYEPYLTLFGEIP-QD----------TKKT----------------------GFD-SDAC SMYGNES------KPL------------------------------CVAVD-KENVPAFP KWLPTILLCVYLLITNILLVNLLIAIFGFTIGVIQDNTDK------------FW------ ---KFQRFSLIEEYCHR----LPVPFPF-------------------------------- ----------------------------------------------------VLVAYIYV LIKGI----------------------------------IGLLDKDK--------NQGPS TCC------------------------------------------HENDK-I-------- -------------------------------LLWES--VMKENYLVKKNKK-PV-DASEK VASLN-----------------DYLKTT-------------------------------- -----------------------------LKERFDQVENQLKNIS--------------- -----------------------------------ECL---------LEVTVNLKKPSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DQTGIHQSHDTEDHRDVPSDNYRV-------------------------------- -----------------------------RGNSHSQH----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006629107.1_LG3_trpm1_TRPM1_Vertebrata_TRPM1 ME---------------------------SRSIRGRKDAGSRG---GKFPGSLRR----- ---SGSFKRTSIKR----------TASG-----SQKGQKA-------------------- -------------------------------------------------------W---- -------IEKTFQKRECIQVFPNNKDPN-------------------------------- -----------RCCCGLLISQHLAVLPGSVSSKGAE-ESNQL-----------VPADPQA EKWSVSKHTQATSTDAY---------------------------GIIEFQGGGHSN---- -------------KAMYIRV-----------------------------S-------YDS -KPDNLLHLMVKDWQLE--------------------LPTLLISVHGGLQNFDL------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- SGVSTG------------------------------------------------------ ----VIRHVGDALKDHC--------------------SKSRGKICAIGIAPWGIVENKED LIGR-----DVTRPYQTMSNP--------------------------------------- ---LSKLSVLNSSHSHFILADN----------------GTYGKYGAEVKLRR-------- ---------------------------QLEKHI--------------------------- ---SLQ------KINTRL-------------------------------GQG----VPVV CLIVEGGPN--------------------------------------------------- VISIVLESLREEP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDIISFAHK-----------YSEEG-------------GIISD-SLRDQLLVTIQ- ---KTF-N---------------------------------------------------- --------HSRNQ----AQHFFLMLMECMKKK--------------------ELITVFRM --------------------------GSEGQQ-----DIEM-----AILTALLKG----- ------TNASA----PD-------QLSLALAWNRVDIARS----------------QIFV YGHHWPPLTSLG-AADASSQDRDKSPAVSTRTTRSKGRAKGKRRAGKGKDEPEEETDPRK LELLNWVNALEQAMMDALV-LDRVDFVKLLIE------NG-------------------- --------------------VNMHHFLTIPRLEELYNTRLG------------------- ------------------------------------------------PAN-TLHFLVRD VK----------------------KGNLPPDYHISLIDIGLILEYLMGGAYRCHYTRKSF RTLYNNLFG----------------PKRLKALKLLGMEDDEP------------------ -PSKGKKN----KKKKKKEEEVDIDVDD----------PEVSRFQYPFHELMV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFLWQRGEEA--------- -----MAKALVACKLYKSMAHES-SESE------------MVDDISQDLDNHSKEFGQLA YEL---LDQSY-KHDE-----------------------------------QVAMKLLTY -------------------------------ELKNWSNSTCLKLAVA-----AKHRDFIA HTCSQMLLTDMWMGCLRMRKNPG------------------------------------- ------------LKVISG-IIFPPTIL----------FLEF-RMNEDLSC---------- ------------------------------------QTSGDNEDGKDKEEENT----VNK -------------DGNL-DSASKKGD---------------------------------- ----EEDG----------------NKKQRRVPI--------------------------- ----GMKIYEFYNAPFTKFW-------FY-------------TISYLLYLMLFNY----- -----VILVKM---------------------------------------ERWP------ ------------------------------------------------------------ --------------------------------------------------SLQEWIV-IS YILTLALEKVREILM--------------------------------------------- ----------SEPG------------KLKQKINVW------LQEYWNITDMVAISVFLMG LLL-RLQNQ----------------PYMGYGRVIY------------------------- ---CVDIIFWYIRVLDIF-GVNKYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQA ILHPDEEPTWRL---------------------------------------A-----RNI FYMPYWMIYGEVFADQ----------IDLY----------------------AMEINPPC GDNLYDEDGK--KLPP------------------------------CIPGA--------- -WLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHDR----PVLPPPL-------------------------------- ----------------------------------------------------IIFSHIYI ILKRL----------------------------------CC-RCRKRHEGDLDERDRGLK LIL----------------------------------------SEEELKK-L-------- -------------------------------HEFEE--QCVEEYFQEKEDE-QL-SSNDE -----------------------RIRVTSERVENMSMR----------------LEEVNE --REH-----------------------FMKASLQTVDLRLAQLE--------------- -----------------------------------EFS---------GRMVNALEKLAGV -D-K-------------------------------------SELTHARSRASSEC-DPTF L---------------------------------------LRQS-----SVNSSDGYSIY RYHLDGDDHSWDDAGSS----------------------LSPGVQRR----HCKAKEEKE AG----------------------------------------ERKKQLTPECQGG----- -----------YFHSSSTSAVTTKDCGQ-------------------------------V TDVAPD---------------------------PRHPGSCVDILISSSDQKT-------- ----------------------------------------------------------QL EADSSDPHRHTR-------------------------RPEPTANGQAAVRGVLG------ ----------------------DRG------------LTVERAKLEAA------------ ----------------------------ISYPLERSKALRYYPSQTFSTSPSSATKSRSS F--IFP---PATGE-------------------NVPGDEGIWGRDC--SSLMDQVTKS-- --------PAGPWTA--CFEPQAQ--PG---------LLGP---------------SPW- ----------LSITKPPARDNRG------------------IP------------LSEAE RQ-------------AEI-----------------------KQQAVGTEEENE---P--- -------------------------------------------------------CPAEE GRTDMDHLFVAEDRM--------------------------------------------- --------------------------YPSLRSKSLNANPRKM-KTRGDSAE--------- -----KLRAASS-----V------------------KDIVTA---CST---------MEE EGNTETP--MEEG--------------LK-KSAETD-C---------------------- ----- >Lepisosteus:oculatus_Spotted:gar_XP:015214648.1_LG12_trpm2_TRPM1_Vertebrata_TRPM2 -------------------------------------------------------MD--- LAKWSTEESQDWR-------G-EKQVDE----NVLRSSEGDILPSE-------------- --------------TNIISHTWPEMLPGSENKIHPDEPDGKVVLTAFEKRCSIKSW---- -------IKQNIKKKECIYYVEASS----------------------------------- ---------KAICKCGYQKTSHSGEALKPDEF------------------------L--G ELWDPRKHVREVPTDAF---------------------------GDITFPGLGQK----- -------------VGKYVRV-----------------------------S-------SDS -STETLYQLMTEFWGLS--------------------PPNLLISVTGGAKNFYM------ -----------KSRLKVMFRRGLIKVAHT------------------------------T GAW---------------------------------IVT--------------------- GGTHAG------------------------------------------------------ ----VMKHVGKAVRDYSMST-----------------SSKDGQIVAIGIATWGTVHNRQN LI---DPEGKFSGYYPLDETS--------------------------------------- ---QGRLSCLDINHSHFILVDD----------------GTHGKYGVEIALRS-------- ---------------------------KLEKLI--------------------------- ---SEQ------PLGNR--------------------------------DGS--VTIPAV CVVLEGGPG--------------------------------------------------- TLNTIYNAVING------------------------------------------------ -------------TP---------------------------------------CVILGG SGRIADVIAQLAN-LPVS-----QVTVS--------------------LIKKQLKRFFS- ---KEYDT---------------------------------------------------- --------FSELK----IIEWTKKIQDIIRMQ--------------------QLLTVFRI --------------------------DEEGRS-----DVDV-----AILKALLKA----- ------SKASD----SLGHGNWERQLELAVAWNRVDIAES----------------EIFT EDRQWK------------------------------------------------------ ------SSDLHQATLSALI-GNRTDFVKLLLE------NG-------------------- --------------------VSLKEFLTEDILLELYNNL--------------------- ------------------------------------------------LPGSLILRKIAK RLKEEKGKKGQD---------------LKGKQRITLSHVSEELRLLLGSYTQPLYP---- ------------------------------------------------LPAPRRRF---- EIPNHDIRIMFDSKSQIELQDIASTAEG----------KTLKTLEDPARDLFL------- -----WAILQ----------------------------NRKEL----------------- ----------------------------------------AEIAWEQCRDN--------- -----IAAALAASKILKILA-EE-EEG----------------DESDEMKKLADYYEHQA IGV---FTECY-GRDE-----------------------------------LRAQKLLTR -------------------------------LSKSWGRTTCLRLALE-----ADNKSFVA QTGVQAFLTTIWWGELTVDTKLW------------------------------------- -------------RVLLC-MLFFPLIYT--------GLVTF-RRDEEIQ----------- ------------------------------------------------------------ ------------------KEIQRNKEID-----------GLETMA--------------- --FGHP-------------------ETKLWTNFRRRQEQVILVPLSF------------- ----IRRFKNFFTSPVVTFY-------WN-------------VMSYFGFLWLFAY----- -----VLMMDF---------------------------------------QVSP------ ------------------------------------------------------------ --------------------------------------------------SWTEILL-YV WLASLLFEEIRQLFH--------------------------------------------- ---------DPDGF------------GVQKKAQMY------FNDTWNKVDMLSIFIFIAG LSC-RLTTT-----------------AFYDGRIIL------------------------- ---CFGFIIFCLRLMAIF-AVSKTLGPKIIIVKRMMK-DIFFFLFLLGVWVVAYGVAMQS ILIHNETQLNWI---------------------------------------F-----RGA VYEPYLTIFGNIP-SR----------IDSV----------------------NFD-NSTC SLNGDDPL-----MPK------------------------------CPVLN-ADGTPAFP DWLTIILLCVYLLFANILLLNLLIAMFNYTFQEVQDHTDN------------IW------ ---KFQRYQLIEEYHSR----PSAPPPF-------------------------------- ----------------------------------------------------IIFSHIFF FIRRI----------------------------------ILRRPSQR--------HKMFH NEL----------------------------------------SAMGEAE-L-------- -------------------------------LSWET--FMKENYLASQKQE-RN-QSTEY -----------------------KIHDTAEKVGVVVDL----------------LEGEHN -RESA-----------------------SLVKRLAKLEEQVSQST--------------- -----------------------------------KAL---------QWIMNALKSNSL- -E-T-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KEDATFL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------Y-AIRLPS- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AY----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015222993.1_LG2_trpm3_TRPM1_Vertebrata_TRPM3 -----------------MAKKKWGSRGEVERGCSTRDDASGRGASRGRFTESWKRLS--- ----S--RQGSTKR------------SGLSSQQTL-AQKS-------------------- -------------------------------------------------------W---- -------IERAFSKRECVHIIVSAKDHY-------------------------------- -----------RCCCGRLIGQHVGLPPSISSSQNDK-NE-RL-----------AKNDSLP EKWSISKHTQLSPTDAF---------------------------GTIEFQGGGHSN---- -------------KAMYVRV-----------------------------S-------YDT -KPDLLLHLMTKEWQLD--------------------LPKLLISVHGGLQNFEL------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- GGVNTG------------------------------------------------------ ----VIRHVGDALKDHA--------------------SKSRGKICTIGIAPWGIVENQED LIGK-----DVVRPYQTMSNP--------------------------------------- ---LSKLTVLNSLHSHFILADN----------------GTTGKYGAEVKLRR-------- ---------------------------QLEKHI--------------------------- ---SLQ------KINTRI-------------------------------GQG----VPVV ALIVEGGPN--------------------------------------------------- VISIVLEYLRDTP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDILAFGHK-----------YSEEG-------------GVINE-SLRDQLLVTIQ- ---KTF-N---------------------------------------------------- --------YSRTQ----AQHLFIILMECMKKK--------------------ELITVFRM --------------------------GSEGHQ-----DIDL-----AILTALLKG----- ------ANASA----PD-------QLSLALAWNRVDIARS----------------QIFI YGQQWP------------------------------------------------------ ------VGSLEQSMLDALV-LDRVDFVKLLIE------NG-------------------- --------------------VSMHRFLTISRLEELYNTRHG------------------- ------------------------------------------------PSN-TLYHLVRD VK----------------------KGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRF RTLYHNLFG----------------PKRPKALKLLGMEDDLP------------------ -MRRGRQ-----KTTRKREEEVDIDLDD----------PEINHFPFPFHELMV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFFWQHGEEA--------- -----MAKALVACKLCKAMAHEA-SEND------------MVDDISQELNHNSREFGQLA VEL---LDQSY-KQDE-----------------------------------QMAMKLLTY -------------------------------ELKNWSNATCLQLAVA-----AKHRDFIA HTCSQMLLTDMWMGRLRMRKNSG------------------------------------- ------------LKVILG-LLLPPSIL----------SLEF-KNKDEMSYMPQDQEAY-- --------------------------------LQEKETEEPEKPVKEKEEEDM-E----- --------FTAMLGKVN-KESSRKKD---------------------------------- ----VEEV----------------QTRHRFIPL--------------------------- ----GRKIYEFYNAPIVKFW-------FH-------------TMAYVGYLMLFNY----- -----IVLVKM---------------------------------------DLWP------ ------------------------------------------------------------ --------------------------------------------------SPQEWIV-IA YIFTNGIEKMREILM--------------------------------------------- ----------SEPG------------KLLQKVKVW------LQEYWNITDLMAILIFSVG LVL-RLQDP----------------PFMSYGRVIY------------------------- ---CVNIIYWYIRLLDIF-GVNKYLGPYVMMIGKMMI-DMMYFVIIMLVVLMSFGVARQA ILNPNEDPSWML---------------------------------------A-----RNI FFMPYWMIYGEVFADQ----------ID-----------------------------PPC GQNITAEDGTYVTLPP------------------------------CKTGA--------- -WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHER----PVLPPPL-------------------------------- ----------------------------------------------------IILSHMTM VLKHL----------------------------------CC-RWRK-HD-DQDERDYGLK LFI----------------------------------------TEDELKK-V-------- -------------------------------HDFEE--QCIEEYFREKDDR-FN-SSNDE -----------------------RIRVTSERVENMAMR----------------LEEVNE --REH-----------------------FMKASLQTVDIRLAQME--------------- -----------------------------------EII---------GRMASALEKVAGV -E-R-------------------------------------GEMNKTRSRTSSDCTDTAY I---------------------------------------LRQS-----SFNSQEGNA-Y KIQEAIEQ-IGEESISP----------------------TSPTIIPRMRSHSFYVGGSRE KS-------------------------G-------------IDKIEGFFKERSLS----- -----------LHRASSSQSVAASKEPK---PVPLP---------------------INT LSVTHD---------------------------SRRPSSCIDIYVSASDESH-------- ---------------------------------------PAPETDSAPL-RL------PL QRDSSLQSEI-----------------------------MEAVLTYSAV-------TDKC SEATG-VFEDSAAV--------DLSMGS--S---HVTESLQHWDLDPP------------ ----------------------------QH--LERSKSSRYLSAAPLFLEDTPMVKSH-S L--MFT---P-RG---------------------YYGGLGVQVKAAEYTSITDCIDTR-- ------------------------------------------------------------ -----------CVSACPASTQR------SGSPGGSFEKPQDLS------------ISHPE RE-------------AEL-----------------------SHPGSDNEEP--------- -----------------------------------------------------------E PEPRRGGFGPGS---------------------------------------------TLM G-------PLCGPR----SRLERANSCSSEDSHTTNAHTRKS-FSISDKMD--------- -----RQRNS--------------------------RNPFQR---SKS---------AKP EGKTDSF-----S--------------MR-KLTKTS-AFRSFD-SRQN------------ --YT- >Lepisosteus:oculatus_Spotted:gar_XP:015208857.1_LG8_trpm4_TRPM1_Vertebrata_TRPM4a ------------------------------------------------------------ ----------------------------MRIADK-EKDGAGAGAGAGAGAGAGGQ-A--- ------------GAKN-----------GSTN----------------------QNW---- -------IPKIFQKRACTNFIEDT---SS------------------------------- --------NGALCQCGGTRQSHASVATEDHFG------------------------AAIV SKWDSAQHTTELPTDAF---------------------------GDVEFAGKSKR----- -------------LSHFLRL-----------------------------S-------CNT -DPQSVYRLMTSHWAIP--------------------VPNLVVSVCGGGGKLKM------ -----------KSWVREVLRQGLVKAAQG------------------------------T GAW---------------------------------ILT--------------------- GGLCEG------------------------------------------------------ ----IGRYVGEAVRDHATAS-----------------TQSNTKVIAVGIASWGIVHNREQ LV---NPQGSFPARYYVQN----------------------------------------- --TSCDTFCLDNNYQAFLLVDD----------------GSVGRSGGETGFRA-------- ---------------------------RLENYI--------------------------- ---SHQ------RTGIW--------------------------------GSG-NIEIPVL CMLVAGDEA--------------------------------------------------- MLERVDRSLQDS------------------------------------------------ -------------TP---------------------------------------WLVLAG TGGMADFLCEVLQ-EF--------SSIEQ-------------DELAE-FLQELLKKHFP- ---HS------------------------------------------------------- ----------TEK----LALLTERVIRIMQSR--------------------ELLNVYDA --------------------------EQDGSE-----DFDT-----VILKALVRA----- ------CKRQS----SDSSEYIE-ELKLAVAWNRVDIAKS----------------ELFN GDVVWK------------------------------------------------------ ------YADLEDSMTDALV-NNKPEFVRLFTE------NG-------------------- --------------------LNILDYLTYGRLEQLYCAL--------------------- ------------------------------------------------PVNSLAHQLLDR RRHERRGSSLHSLDTPAAPGPAPAEPAAAPARELTLFEVSRVLRDLLGDACEPFY----- ------------------------------------------SKCLG------------- -----LSRSSGSRKSLKRMNKL---LLG--DCS-----YRQDRCASPWIDLFI------- -----WAVLQ----------------------------DRSKM----------------- ----------------------------------------ATFFWEMAGDS--------- -----VTSALAASKMLRELSRLQ-YDT----------------ESKLSMKDLANRFENLA HDV---FSECY-KNDE-----------------------------------MRCFLLLIR -------------------------------RSPFWGKATCLQLATV-----ADARLFFS HDGVQALLTRIWWGDMDSSTEVW------------------------------------- -------------KLIAT-FFCPPLVYT--------SLIKY-REVEEEVKNEEPQAK--- ----------------------------------ELDSCDGDTIFSMKDIT--------- -----------KNPEEM-EELESLKE---------------------------------- ----KPRDRP-A-----------HSPGKPRPYV--------------------------- ----VARWRQFWFAPVTSFL-------GN-------------VLMYFLFLLLFAS----- -----VLLVDF---------------------------------------KQPPP----- ------------------------------------------------------------ -----------------------------------------------DGPSPKELFL-YF WVFTLVCEEIRQTFF--------------------------------------------- ----------IGNL------------SVLKRMKVY------IQDMWNKCDLTAIVLFIIG LCC-RMFLP-----------------TFEFGRAVL------------------------- ---CLDFMVFALRLLHIF-AVNKQLGPKIIIVGKMMK-DIFFFLFFLGVWLMAYGVANQA LLYPYEPRAEWI---------------------------------------M-----RRV FYRPYLHIFGQIPLED----------IDAA----------------------KMSGEGNC SYDAEEIHMG---MEP------------------------------CTNT--------YA NWLVIILLVVYLLVTNILLLNLLIAMFSYTFSKVQGNSDI------------YW------ ---KFQRYNLIVEYHNR----PALAPPF-------------------------------- ----------------------------------------------------ILLSHINL LIKRN----------------------------------IRKVPSVK--------IQHFM LDL----------------------------------------SKQKDNR-L-------- -------------------------------LTWEA--IQKENFLAQQNKC-KR-ESDSE -----------------------RLKRTSNKVDNVLKH----------------MAEIRD -----------------------------HDRRLKVLESEMEYCS--------------- -----------------------------------SAL---------SWMVEALSQSNVI -K-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TRPPPTHKDPTTPL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:015222646.1_LG2_trpm6_TRPM1_Vertebrata_TRPM6 ------------------------------------------------------------ ----------------------------------MKSRKT-------------------- -------------------------------------------------------W---- -------IEETFCKRECMMFIPISRGPHRCIPGCQVC----------------------- -------QNLIRCCCGRLIGEHTGLDLSSPLYMSAL--------------------ESER EEWSVEKHTKASPTDAF---------------------------GTIDFQDGARSF---- -------------HAKYLRV-----------------------------S-------YDT -KLDQLLHFIVKEWQMD--------------------LPKLVISVHGGNHNFEL------ -----------PPKVKQIFGKGLIKAAET------------------------------T GAW---------------------------------IVT--------------------- EGINAG------------------------------------------------------ ----IARHVGDALKTHG--------------------DHDFRKRYAIGIAPWGVIENQSD LIGK-----DVVCPYQTLGNP--------------------------------------- ---LSKLMCLNSLHSHFVLVDD----------------GTVGRFGSEMNLRR-------- ---------------------------KFEQII--------------------------- ---GLQ------KIHSRL-------------------------------GQG----VPVV AVLVEGDPS--------------------------------------------------- AVPLVWEYVRSTP----------------------------------------------- ------------PVP---------------------------------------VVVFEG TGGAADLLAFVHK-----------QTAEG-------------RGLPP-DIKEDTLFMIQ- ---NSF-S---------------------------------------------------- --------FEKTQ----CNQLFKTLMECMDHR--------------------DSITVFDA --------------------------ESDDQQ-----DVCT-----AMLTVILKG----- ------THASA----SD-------QLSIALAWDQVDIAKN----------------HILV YGQHWK------------------------------------------------------ ------VGSLEQAMLDALV-MDRVNFVKLLIE------NG-------------------- --------------------MCMNRFLTVSRLEELYNTWQG------------------- ------------------------------------------------PTHSLLYHLVKD VK----------------------QSHLPPDYKISLIDVGLVIEYLIGGAYRSTYTRKHF RVLYNSLYRQK--KKISQGNSVSFNNDSKQLYGRHGNEDSVP----------QSYFFRTA QPYKRKEKTLFHQKSKKKQKADLIFSQE----------NETPLFTYSFNDLFV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFLWQHGEEA--------- -----MAKAVVACKLYRAMANEA-KESN------------MGDNTSEELKIYSQEFGQLA VDL---LDNAF-RQNE-----------------------------------RMAMKLLTY -------------------------------EMKNWSNFTCLKMAVS-----SGLRPFVS HTCTQMLLTELWMGRLNMRKNSW------------------------------------- ------------YKVILS-ILLPPTIL----------MLEF-KSKAEMSHIP-------- ------------------------------------QSQESHQLNLESGSHGS-N----- --------GKDQPQVND-SDPERGPE---------------------------------- ----KPEDIDFS-----------LTTQQKGLFW--------------------------- ----TRKVYEFYNAPIVKFW-------FH-------------TIAYMIFLMLFTY----- -----TVLVKM---------------------------------------EPKP------ ------------------------------------------------------------ --------------------------------------------------TIQEWLV-II YVFTTAVEKVREVFM--------------------------------------------- ----------SEPG------------KPIKKINVW------FSEYWNCTDFLAILLFVVG FGL-RWEDV----------------PMRTAGRIIY------------------------- ---CLDIIFWYVRLLDLF-AVNQHAGPYLMMIAKMTA-NMFYIVIMMAIVLLSFGVSRKA ILSPNEPPSWTL---------------------------------------A-----KDI VFQPYWMIFGEVYAGE----------ID------------------------------AC AENNI-----------------------------------------CSPGA--------- -FLTPFLQAVYLFFQYIIMVNILIAFFNNVYFEMKSISNK------------LW------ ---KYNRYRYIMTYHEK----PWLPPPF-------------------------------- ----------------------------------------------------ILLSHLSL CISTI----------------------------------YQHQSKE----LEHGKHVGLK LYL----------------------------------------SIEDLKK-L-------- -------------------------------HDFEE--KCVVMYLYEKNEN-FN-CNTVH -----------------------RIKTTLEKVEEMCLQ----------------LKDVAE --KVF-----------------------FVKETLQSLDNQLGHLQ--------------- -----------------------------------DLS---------ALTVDTLSVISAA -G-SLKEEEELLGHKRH-HSCERLPHSWSN--YAQSVEDLNNKIKKKY--CSTPPSLLRT LGHDPQ-----------P------------LQTLGCNSNEEQQTHSKVRALNSI-----D KEEKEGGKILIE--VHKDHQS---------------KVLCVPLMLSCCKNNSLTNIKSAG NSLPESIPETLHSSM---------RQSGEVLIKTGIPDIQVAQNSDTWQENKTFS----- ---------LGTSTEVSDQTLMSDCHAE---ESKGGFVNLAFSEGNEPGIFQLPQ----- MRYGRKSHLTTCNRDE------------SENSLQKDQVTNSHSLVCSSVSMEIAPPS--- ----QQSCTLVCGNTVEKNW-----------------KSHSLRAERGNM-MLNPSKDRET SKSSEIYPCA-----KPVPKMQNLKRKTVKIQETTPNLPLPVITVHGCSPIPCMNSESAL QKDENLQIEQNLKRDWSNITSFNQLSFDQMSFVAHR-LRHHESPSNLVQSIEHSGFHYQE QTSTSAWNSRKKTPSRRSSEQIFGVTDAKSTSFKTSEDLNHHYSA---VERNNLMRLAQT I--PFTPVSLIAGEEVTIYRLEESSPTSLSNSVSFWSKQGL-VAMIEPLICKQM-----D SGLRRAMKVVCTW-----AEGDVLK-PG---------AVYI------VKSFSPELVRTWK KIYQDSTVLHLCLREIQQQRAA-----QKLMYIFNQMKPHTIPYSPRVLDVC-LLYCHST EEWL----TIEKNLNGDF-----------------------KKYNSTNGEE--------- ----------------------------------------------------------VT PMSFLEETILAFSHW--------------------------TYEYSR--GELIVLDLQGA G-------ENLTDP-SVIKAEDKDEQDMIFGPANLGDGTIQN-FIEKHQCNR----CC-- ----KQLKLPDL-----R------------------KNTLTP---GKINP---------- ------------A--------------FE-DDCSDI-VTRL------------------- ----- >Lepisosteus:oculatus_Spotted:gar_XP:015193971.1_LG27_trpm5_TRPM1_Vertebrata_TRPM5 ------------------------------------------------------------ ------------------------------MTEPPDQPLN-------------------- -------------------------------------------------------T---- -------DQQRDLCRNCGETVEVPQGLDP------------------------------- ---------ETACRC--------FCVLNEQKG------------------------CLVM DTSSRETQSNDFKAEQVRDSEID------------------SCGGEIEFIGTSKK----- -------------RGKFIRV-----------------------------H-------CTT -DPAAIYELLTEEWCLM--------------------APHLVVSLVGGDELFQM------ -----------RPWLRDTVRKGLVKAAQS------------------------------T GAW---------------------------------ILT--------------------- SGLRFG------------------------------------------------------ ----ITKHLGKAVRDHSLAS-----------------TSSKVKVVAIGIAPWKMIHNKEV LL---TAKPDKPALYQSEDLP--------------------------------------- ---HGSVYSLDCNHSHFVLVDE----------------DEEHPG-GTTEMRI-------- ---------------------------KLLKHI--------------------------- ---SEQ------HTGYG--------------------------------GTG-SIEIPVL CLLVHGEPK--------------------------------------------------- ILKRMYRGMINS------------------------------------------------ -------------TP---------------------------------------WLILAG SGGIADILVTLMN-GP--------CDPD--------------------SVQEQLVETF-- ---HT--E---------------------------------------------------- --------FEWAN----ISKWTKLIHKILEHR--------------------HLLTVHDP --------------------------EQEGSE-----ELDT-----VILRALVKA----- ------CKSQS----QEAQDYLD-ELKLAVAWNKVDIAKS----------------EIFN GDVEWR------------------------------------------------------ ------ACDLEEVMMDALV-NNKPDFVKLFVD------NG-------------------- --------------------INMNEFMTYGKLQDLYCSV--------------------- ------------------------------------------------SEKSLLHELLLK KHEEKQ-------LILAARNPGGHHESVPKKTRFTLHEVSKVLKDFLHDSCKGFY----- -------------------------------------QDSTK------------------ -------RTPTEKSGKTRTS-------HGNKCLP----DMSQKCDNPWRDLFL------- -----WAVLQ----------------------------NRQEM----------------- ----------------------------------------ANFFWAMGPEA--------- -----VAAALAGCKILKEMAHLE-SEA----------------ESARSMKE--AKYEQFA LDL---FSECY-SNSE-----------------------------------DRAYALLVR -------------------------------KTKYWSKATCLNLATE-----ADAKSFFA HDGVQALLTKIWWGSMTADTAIS------------------------------------- -------------KLVVS-FFFPPLIWT--------NFIKFSSEDEQHGGRGGEEFA--- ----------------------------------ELDSLDTEKALLLTEEEN-------- ------------IESRK-VESQSPQN---------------------------------- -------------------------HNVWSTFL--------------------------- ----FRRWQRFWSAPVTVFL-------GN-------------VIMYFAFLFLFTY----- -----VLLVDF---------------------------------------RPPPP----- ------------------------------------------------------------ -----------------------------------------------DGPSMAEITL-YF WVFTLVLEELRQSFF--------------------------------------------- ---------TDEDT------------SIVKKFKLY------VEDNWNKCDMVAILLFVFG VSC-RMLTS-----------------MYEAGRTVL------------------------- ---ALDFMVFTLRLIHIF-AIHKQLGPKIIIVERMMK-DVFFFLFFLSVWLLAYGVATQA LLHPNENRVDWI---------------------------------------F-----RRV LYRPYLHIFGQIPLEE----------IDAA----------------------KMP-ELNC TTDLFEIMEE--TLPP------------------------------CPNL--------YA NWLVILLLVIFLLVTNVLLLNLLIAMFSYTFQVVQEHTDI------------FW------ ---KFQRFNLIVEYSSR----PALAPPF-------------------------------- ----------------------------------------------------IIISHISQ VVFSM----------------------------------FKKS-ESK--------TDPLE REL----------------------------------------PEALDQK-L-------- -------------------------------MTWET--VQKENYLAKLEKR-KR-ESSEE -----------------------RLRTTTSKVQSLLKI----------------VGGHKE -----------------------------QEKQLLSVETQVKYCS--------------- -----------------------------------DVL---------SWMAECFSQSTL- -R-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---DRNVPKDPRSAGKWSKQQQKTTTE--------------------------------- ------------------------------------------------------------ ---------------------------------------------EG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------NKDSRKM D-------SAQSQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007907056.1_NW:006890058.1_trpm1_TRPM1_Vertebrata_TRPM1a -------------------------------------------------------MN--- ----GSFKRTSIKR----------TVSG---SQK--GHKA-------------------- -------------------------------------------------------W---- -------IEKTFQKRECVHIIQNTKDPQ-------------------------------- -----------KCCCGQQTSQHTSTFHSAQRNSKGD-ESKQL-----------VKADASP EKWSVLKNTQASPTDAY---------------------------GVIEFEGRTHAN---- -------------KAMYIRV-----------------------------A-------NDT -KPEHLLHLMVKEWELE--------------------LPKLLISIHGGLQNFEL------ -----------QPKLKQVFGKGLIKAAVT------------------------------T GAW---------------------------------IVT--------------------- AGVSTG------------------------------------------------------ ----VIRHVGDALQDQP--------------------SKSRGRICAIGLAPWGIVENRME LIGK-----DVTRPYQTMLNP--------------------------------------- ---LSKLSVLSSTHTHFILADN----------------GTVGKYGAEVKLRR-------- ---------------------------QLEKYV--------------------------- ---ALQ------KINTRL-------------------------------GQG----VPVV CLIVEGGPN--------------------------------------------------- VISIVLESLREDP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDILAFAHK-----------YSKEE-------------GIINE-AVRDQLMITLQ- ---KTF-N---------------------------------------------------- --------SSRTQ----AQQLFVLVMECMKKK--------------------ELITVFRL --------------------------GSESQQ-----DIDL-----AILTALLKG----- ------TNASP----PD-------QLSLALAWNRVDIARS----------------QIFV FGNCWPPMINIT-------KDQEKEKSSAPKAKPAKVKGKGKKK-GKSKSPVEEETDPRK LELLNWVNSLEQAMMDALV-LDRMDFVKLLIE------NG-------------------- --------------------VNIHNFLTIPRLEELYNTKLG------------------- ------------------------------------------------PPN-TLHYLVRD VK----------------------KGNLPPDYHISLIDIGLVMEYLMGGAYRCNYTRKSF RSLYNNLFG----------------PKRPKALKLLGMEDDEP------------------ -PTKGK------KKKKKKEEEFDIDLDD----------PMVSRFPFPFHELLV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFFWQHGEEA--------- -----MAKALVACKLYKAMSHEC-SESE------------LVDDVFQDLDNSSKDFGQLA IDL---LDQSY-KHDE-----------------------------------QVAMKLLTY -------------------------------ELKHWSGSTCLKLAVA-----AKHRDFIA HTCSQMLLSDMWMGRLRMRKNPG------------------------------------- ------------LKVMLG-IIFPPAIL----------FQEF-KTSDDMSY---------- ------------------------------------EDCGVTEEGKEKEEDNS------- -------------SADA-DALSRKGD---------------------------------- ----EEEG----------------KRKHKSIPI--------------------------- ----GKKVYEFYNAPIVKFW-------FH-------------TLAYLSFLLLYNY----- -----VILVKM---------------------------------------EAMP------ ------------------------------------------------------------ --------------------------------------------------TIQEWVL-IS YIITLSIEKIREVLV--------------------------------------------- ----------SEPS------------KLKQKIKVW------LQEYWNITDMVAITIFNIG VVL-RLQNQ----------------PYMSYGRVIY------------------------- ---CVDIIIWYIRVLDIF-GVNKYLGPYVMMIGKMML-DMLYFVVIMLVVLMSFGVARQA ILHPDEEPSWRL---------------------------------------A-----RNI FYMPYWMIYGEVFADQ----------IDLY----------------------AMEINPPC GENLFDEDGK--RMPP------------------------------CIPGA--------- -WIIPAIMACYLLVANILLVNLLIAVFNNTFLEVISISNQ------------VW------ ---KFQRYQLIMTFHQR----PVFPPPI-------------------------------- ----------------------------------------------------IIFSYVSM IIHRF----------------------------------CF-CCRK--DSEIDERDRGLK LIL----------------------------------------SEEELKK-L-------- -------------------------------NEFEE--QCVESLFAEKEDR-EL-SSNQE -----------------------LVRITADRVENMAMR----------------LEEVNE --REH-----------------------FMKASLQTVDLRLAQLE--------------- -----------------------------------EFT---------SRMVNALEKLSGI -D-K-------------------------------------TELRRTHSRCPSEYDTAPY L---------------------------------------LRQS-----SINSTEGF--H RYHMEADDSPFDEGTGQ----------------------LSLAIESHGRTSSIKLREEKA FG----------------------------------------EGMRHLTPDWHFG----- -----------LHRAASTHSIGLAGSRK---N---------------------------- LAVLPD---------------------------TRRPNSCVDIFISSSDDYEAPI----- ---------------------------------------------EQNF-LH------PI KTGSNEHEGT-----------------------------IVS------------------ ---SG-V-------------------------------SQERTKLEAC------------ ----------------------------ISFPLERSRATQYFPPQPLDMCQT-MIKSR-S F--IFP---PGDGFS--------SEP---EDWTRVHG-------SVRYSAKPDSTLSP-V GGLT------SQW------EHKFG------------------------------------ ---------------------------------------QELPQKQ-------LATKGTF HQ-------------SSL-----------------------PTPESMAEEKQH------- ---------------------------------------------------------LLE GEDSDTGDMAYS------------------------------------------WMLSSD R-------PAQKSE-NFLSVTEARYGFSSPRSKSLHNPNRKK-KSTMGMSFS-------- -----KPKQASS-----V------------------KNLLDPF--GDW---------QQP KTKPTRS-----T--------------RT-KPSETF-C---------------------- ----- >Callorhinchus:milii_Elephant:fish_XP:007888803.1_NW:006890069.1_trpm2_TRPM1_Vertebrata_TRPM2 -------------------------------------------------------MS--- --------TQEFNLVHRVQVGSRRSMLTLDTVKSLKRN-----PS--------------- ---------------------FRSRLLNSTNLI-------------LSQQDGFKKW---- -------IYENLMKMECVCYVENPEASVA------------------------------- --------GKLVCSCGYLKDHHSGEAISHGYR------------------------QE-G NKWIYERHVRQVPTDAF---------------------------GDIVFEG--QR----- -------------NGKYVRV-----------------------------S-------SGT -APATLYELMTKQWGLN--------------------PPHLLISVTGGAKNFYL------ -----------KPSLRNLFCRGLIKVAKS------------------------------T GAW---------------------------------IIT--------------------- GGSHAG------------------------------------------------------ ----VMKHVGEAVRRYTMTS-----------------SSKEGEVVAIGVATWGIVHNREC LI---NKEGMFPVEYTLDEEN--------------------------------------- ---QGRLSCLDHNHSHFILVDD----------------GTHGKYGVEILLRS-------- ---------------------------NLEKYI--------------------------- ---SKQ------RMGTE--------------------------------DVG--IETPII CVVLEGGEG--------------------------------------------------- TLNTIHSAMMNG------------------------------------------------ -------------MP---------------------------------------CVIVEG SGRAADVLASVAN-LPVS-----QITIS--------------------LMQKQLRTFFS- ---ETFNT---------------------------------------------------- --------FSDRR----IISWTKKVQDIVRMH--------------------QLLTVFKA --------------------------EKARNQ-----ELDV-----AILQALLKA----- ------SSNAS----HLGKENLEHQLKLAVAWDRVDIAKS----------------EIFT DKKRWK------------------------------------------------------ ------SSNLHQAMFAALV-GNKPGFVELFLE------NG-------------------- --------------------VNLGEFVTPEILERLYNNV--------------------- ------------------------------------------------PQSTLLYKKLRK AVEGERRRDASD--------------NVDAKQRILLHHVSGILRELLGDFTEPFYEK--- ------------------------------------PKDHQCKKHLSITQLTQHIL---- PISHPELKHSDSQESEICDDVE-------------------QEFEEPARDLFL------- -----WAILQ----------------------------KRKML----------------- ----------------------------------------ANILWVQSSDS--------- -----IASALVATKILKKLSSEA-NDT----------------DLSEAMEELAQEYEDRA IGV---FTECY-RKDP-----------------------------------KRAQKLLIR -------------------------------VSNAWGNTTCLRLAIE-----GDDQNFMA QGGVQSFLTKIWWGDISVDTQTW------------------------------------- -------------QVLLC-MVLWPIIHS--------NFISF-RQDEEIRMK--------- ----------------------------------KASKVDSSSDIS-------------- -----------QSPSLS-EDLQSTKQ---------------------------------- ----KP-------------------KSISRTILMPTVKEEDLKPLSC------------- ----CERLRAFYTAPVVVFY-------WN-------------VLAYFGFLWLFSY----- -----VLLIDF---------------------------------------QSQP------ ------------------------------------------------------------ --------------------------------------------------SGREYFL-YL WLFTLVCEEIRQLFS--------------------------------------------- ---------NPDDL------------GFWKKAILY------FSDIWNKLDVAAILVFLVG LAC-RWISE-----------------TFYYGRIIL------------------------- ---CLDFIIYCFRVMHIF-AVNKTLGPKIIMVKRMMK-DIFFFLFLLALSIVAFGVAKQG ILIHNEDRLDWI---------------------------------------F-----QGV VYHPYRMIFGEIP-ID----------VGFS----------------------GFD-LNQC TLTGSDPY-----KPK------------------------------CPEHD-SNNNPIFP EWITVILLCIYLLFTNILLLNLLIAMFNYTFQLVQENTDK------------IW------ ---KFQRCHLIEEYHSR----PSAPPPF-------------------------------- ----------------------------------------------------IILSHIIL FVQCI----------------------------------IIRRPPQI--------RKKLK KRL----------------------------------------EEEEDFA-L-------- -------------------------------LLWEG--IMKENYLAKSIHK-MG-QSTEQ -----------------------QIRSTADKIDTVTEI----------------LDMTKE GSKAG-----------------------PVDQRMSHLEEQMIQTT--------------- -----------------------------------RAL---------NWIMNALIEKKF- -G-S-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KDSAPMLNIPESKSKEQEDSDDEDK-------------------------------- -------------------------------DSKTLHHVDARSFFYPDSNIERFPVPDE- ----------------KVPW---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007904772.1_NW:006890220.1_trpm3_TRPM1_Vertebrata_TRPM3 MQWPLGVRNLLEGLGMRTNRKKWQSPGEVERRCSVRDEGGGRRSSRGKFAESWKRLS--- ----S--KQSSLKR------------SGLPSQQQ--AQKS-------------------- -------------------------------------------------------W---- -------IERVFYKRECVHIIPSSKDPH-------------------------------- -----------RCCCGRLIGQHVGLPPAISISQNYS-IEGRI-----------TKNDLHS EKWSIAKHTQLSPTDAF---------------------------GTIEFQGGGHSN---- -------------KALYVRV-----------------------------S-------FDT -KPDLLLHLMTKEWQLD--------------------LPKLLISVHGGLQNFEL------ -----------QPKLKQVFGKGLIKAAMT------------------------------T GAW---------------------------------IFT--------------------- GGVNTG------------------------------------------------------ ----VIRHVGDALKDHA--------------------SKSRGRICTIGIAPWGIVENQED LIGK-----DVVRPYQTMSNP--------------------------------------- ---LSKLTVLNSMHSHFILADN----------------GTTGKYGAEVKLRR-------- ---------------------------QLEKHI--------------------------- ---SLQ------KINTRI-------------------------------GQG----VPVV ALIVEGGPN--------------------------------------------------- VISIVLEYLRDTP----------------------------------------------- ------------PVP---------------------------------------VVVCDG SGRASDILAFGHK-----------YSEEA-------------GVINE-SLRDQLLVTIQ- ---KTF-N---------------------------------------------------- --------YSRTQ----AQHLFIILMECMKKK--------------------ELITVFRM --------------------------GSEGHQ-----DIDL-----AILTALLKG----- ------ANASA----PD-------QLSLALAWNRVDIARS----------------QIFI YGQQWP------------------------------------------------------ ------VGSLEQAMLDALV-LDRVDFVKLLIE------NG-------------------- --------------------VSMHRFLTISRLEELYNTRHG------------------- ------------------------------------------------PSN-TLYQLVRD VKKREY----------QAFSWIYFQGNLPPDYRMSLIDIGLVIENLMGGAYRCNYTRKRF RTLYHNLFG----------------PKRPKALKLLGMEEEPP------------------ -LRRGR------KTTKKREEDVDIDLDD----------PEINHFPYPFHELMV------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------ALFFWQYGEEA--------- -----MAKALVACKLCKAMAHEA-SEND------------MVDDISQELNHNSREFAQLA VEL---LDQSY-KQEE-----------------------------------QMAMKLLTY -------------------------------ELKNWSNSTCLQLAVA-----AKHRDFIA HTCSQMLLTDMWMGRLRMRKNSS------------------------------------- ------------LKVILG-ILLPPSIL----------SLEF-KNKNEMSYMPHSQESP-- --------------------------------VLLKEVEEPEKPVKEKEEEDM-E----- --------FTAMLDGVN-GETVRKKD---------------------------------- ----EAEV----------------QTVHGIIPF--------------------------- ----GRKIYEFYNAPIVKFW-------FY-------------TMAYIGYLMLFNY----- -----IVLVKM---------------------------------------DVWP------ ------------------------------------------------------------ --------------------------------------------------SVQEWIV-IS YIFTLGIEKMREILM--------------------------------------------- ----------SEPG------------KLLQKVKVW------LQEYWNITDLMAILLFSVG MVL-RLQEQ----------------PYMSYGRVIY------------------------- ---CVDIIYWYIRLLDIF-GVNKYLGPYVMMIGKMMI-DMMYFVIIMLVILMSFGVARQA ILHPNEDPSWRL---------------------------------------A-----RNI FYMPYWMIYGEVFADQ----------ID-----------------------------PPC GVGLT-EDGK--PLPP------------------------------CITGA--------- -WIIPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ------------VW------ ---KFQRYQLIMTFHER----PVLPPPL-------------------------------- ----------------------------------------------------ITFSHMTM VFQHI----------------------------------CC-RWKK-QESDQEDKDYGLK LFI----------------------------------------TEDELKK-L-------- -------------------------------HDFEE--QCIEEYFREKDDR-FI-SSNDE -----------------------RIRVTAERVDNMSMR----------------LEEVNE --REH-----------------------FMKASLQTMDIRLAQLE--------------- -----------------------------------EVT---------GRMVPALEKLAGI -D-R-------------------------------------GDANKSRSRASSDGTDTAY M---------------------------------------LRQS-----SFNSAEGNN-Y KLPECGEQ-AGEESISP----------------------SSPTIMPRMRSHSFYAVITKE RP-------------------------G-------------VERADYNFKERSFS----- -----------LQRATSTQSVAVVKDAK---LAPQP---------------------VSV SPSMSETKTP---------------------IGTKRPSSCIDIYVSTSEEEQ-------- ---------------------------------------AATMAAESSL-KV------PV AREVTLQSDI-----------------------------VAAMLGNQATSGSPG-LTSKW SEGNG-IYEELFTS--------DKLAAQ--PSTSQAIESLQQWSPDPP------------ ----------------------------VYHALERSKSSRYLAASTIYIEESPMVKSH-S F--MFS---PSRG---------------------YYGSLGVAVKTAEYTSITDCIDTR-- ------------------------------------------------------------ -----------CVSAPPANTEHSP--LSSGSRGDHSSGLDEVS------------TSHPE RE-------------AEL-----------------------SHPSSDNEEH--------- -----------------------------------------------------------E GEVQDKASAAKQ----------------------------------------CFLESTAV E-------PLSNNT-S-LSKLERANSYTASEPNTLNAHAKKS-YSISDKLD--------- -----RQRNSPG-----L------------------RNPFQQ---GRL---------SKP DLKADGF-----S--------------LK-KLSKTT-AFRSFDSSKQN------------ --FT- >Callorhinchus:milii_Elephant:fish_XP:007884444.1_NW:006896180.1_LOC103173670_TRPM1_Vertebrata_TRPM4:like:partial ------------------------------------------------------------ ------------------------------MSIRLESEQI-------------------- -------------------------------------------------------W---- -------IPKVIKKKICSAFLEDT-DSHS------------------------------- --------GQSLCQCGYAKRCHGSVATEDNFG------------------------AAVV SHWNTAEHTTEVPTDAF---------------------------GDLHFVGTQRR----- -------------ASKFLRL-----------------------------S-------TET -DPGIIYSLITHHWKIP--------------------APNLVVSVLGGEGDFRM------ -----------KTWLKDILRKGLVKAAQS------------------------------T GAW---------------------------------IMT--------------------- SGLRVG------------------------------------------------------ ----IGRYVGEAVRDHATAS-----------------TQTVTKVVAMGIAPWGLVHNNRQ LV---NAK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_Elephant:fish_XP:007902997.1_NW:006890183.1_trpm5_TRPM1_Vertebrata_TRPM5 ------------------------------------------------------------ ----------------------------MAHTEP-------------------------- ------------------------------------------------------------ -------HQKNMVGEDCGNDGESFR--------SQYSLNIEL------------------ ------------------------AAVTEQG----------------------------- -FGTRGNKHNGRNNEESVKRI------------------------EIEFSGSGKK----- -------------HGKVARV-----------------------------S-------RNI -SPATLFELLTADWNLL--------------------APSLVVSIMGGNENLPM------ -----------KPWLRD-IWKGLVKAAQS------------------------------T GAW---------------------------------IIT--------------------- SGLRAG------------------------------------------------------ ----VTRLIGEAVRDHALAS-----------------NSSKVKVLALGLSPWEIIQNSEA LA---SGTHCSPASYQIEETV--------------------------------------- ---KGPPYSLDNNHSHFILVED----------------ETED---GTKELLL-------- ---------------------------KLIKHI--------------------------- ---SEQ------QTGYG--------------------------------GTG-SVEIPVL SILVHGHPT--------------------------------------------------- MLQKIYQGMADS------------------------------------------------ -------------IP---------------------------------------WLVLAG SGGLADVIASLVS-QP--------LVPE--------------------IVQEEMQETFP- ---SE--T---------------------------------------------------- --------FAWDD----ILKWTELIQRILANH--------------------HIITVHEA 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HTCTQMLLTDIWMGRLKLRKNTW------------------------------------- ------------LKIVLC-ILLPPTIL----------MLEF-KSKAEMSHIP-------- ------------------------------------QSQEDHQFTQQYNTQNS-G--TDK ------DSSPSYDMEKA-LDITEDSQ---------------------------------- ----DSSA----------------GTRQRGLPW--------------------------- ----TRKIHEFYSTPIVKFW-------FH-------------SMAYLGFLMQFTF----- -----IVLVKM---------------------------------------EPRP------ ------------------------------------------------------------ --------------------------------------------------SVQEWIV-IT YVFTTAVEKAREVFM--------------------------------------------- ----------SEPG------------KISLKLKIW------FQEYWNFNDSVAIVLFFIG FGL-RLAEQ----------------PLQTTGRIIY------------------------- ---SLDIIFWYARLLDFF-AVNQHAGPYLTMIAKMTT-NMFYIVIMMAIVLLSFGVSRQA ILFPHEQPSWHL---------------------------------------A-----RDV VFQPYWMMFGEVYASE----------ID------------------------------PC KDN-----------PD------------------------------CPPGS--------- -FLNPFLQAVYLFVQYIILVNLLIAFFNNVYYEMKSMSNE------------LW------ ---KYNRYRYIMTYHEK----PWLPPPI-------------------------------- ----------------------------------------------------IIFNHIAM FIGRI----------------------------------CR-TRAK-NELAQEGEHVGLK LYL----------------------------------------SNEELKK-L-------- -------------------------------HDFEQ--LCVEKYFHEKNEA-FQ-SSESE -----------------------KVRVTTERVREIEIH----------------LKDVSE --KMY-----------------------CIKESLYCLDSQLGHLQ--------------- -----------------------------------DLS---------ALTVDTLKMISVA -D-SLKVNEVFLGNVTENGDCHRLPRHWTPTTSSKSLDNFCVDIQKTHNYLSAPPALIHG LPKGEQSPICYSNTNVAPRTPEWEKGEEEQISIAD--RDYCKQKTSESDTLTSGVSSE-P KSPHKYRQLLLDQSSLGSSEC-----------SEFR---FSLSLPSTPTLPKLNFIEEMW EKSPCSMPVQFSPHRTGPNDTKEPWEKG--------------RVTAHVSPVRSAG----- --WRGSLPTNPLASVVNNTSLSSGSHSE---QSEGGFVNWAFNEEDEPGIH------GVS LKFQKERFPQPIYHADCNYMDHDPHIDEPHVYNSYSAGSSADNFESISMRRRIPPAR--- -------------------W------IYPLRMNNYYCWRSGFRRKNRSK-VK------VF AKSLDLRRSV-------RQKRIRNNEKFRVQNKPTK-LFMPTIGVNRCLRISSNSPWHGT TECDKNMNEEDGAAKWLM-----SPSFKQLAGYSNPGFCDQESDLVAKESKEILKTSYET GSDHSMWRS---NLNRKCLSNSCI-VDGFPDAFKTSQDLNHHYSA---VERNNLMRLAQS I--PFTPLHLFAGEEITVYRLEESSATNLDKSLSSWSQNGL-TAMIQVLSREEM-----S GVLRRAMKIECTW-----SEDGMLK-PG---------QFYI------IKSFLPEVVKTWQ KMFNNSTVLHLCLREIQQQRAA-----QKLIYTFNRLKPHSVAHTPRFLEVF-LVYCHSV SQWL----TMEKYLGGEF-----------------------RKYNSSNGDE--------- ----------------------------------------------------------II PSSRLEETLLAFSHW--------------------------TYEYTR--GELLILDLQGV G-------ETLTDP-SVIKGEEKTSRGMVFGPANLGEDAMRN-FTIKHHCNS----CC-- ----RKLKLPDL-----R------------------RNDYNP---GKLNAT----SKIIP QKPTPDCDFTSSA--------------FI-HEEK-------------------------- ----- >Callorhinchus:milii_Elephant:fish_XP:007903830.1_NW:006890058.1_trpm7_TRPM1_Vertebrata_TRPM7 ------------------------------------------------------------ ---------------------------------M--SQKS-------------------- -------------------------------------------------------W---- -------IENTFTKRECVYIIPSSKDPHRCLPGCQIC----------------------- -------QQLVRCCCGRLVRQHLGFTASLAVKYSDV-KLGET-----------E--NLEQ EEWSVEKHTSESPTDAY---------------------------GVINFQGGSHSY---- -------------RAKYVRL-----------------------------S-------FDT -KPEAALKLMLKEWQIE--------------------LPKLVISVHGGMQNFEL------ -----------HPRIKQVVGKGLIKAAVT------------------------------T GAW---------------------------------ILT--------------------- GGVNAG------------------------------------------------------ ----VVKHVGDAMKEHI--------------------SRSSRKICTIGIAPWGVIENRND LIGR-----DVVAPYQTLLNP--------------------------------------- ---LSKLNVLNNLHSHFILVDD----------------GTVGKYGAEVKLRR-------- ---------------------------ELEKHI--------------------------- ---NLQ------KIHARI-------------------------------GQG----VPVV ALIFEGGPN--------------------------------------------------- VIPTVLDYLLESP----------------------------------------------- ------------PVP---------------------------------------VVVCEG TGRAADLLAYVHK-----------QTEEG-------------GILPD-GLELEIITTIK- ---KTF-N---------------------------------------------------- --------FSHSE----AQHLFQTLMECMKAR--------------------ELITVYHI --------------------------GSEEHQ-----DIDV-----AILTALLKG----- ------TSLSA----FD-------QLILTLAWDRVDIAKN----------------HAFV YGQQWL------------------------------------------------------ ------VGSLEQAMLDALV-MDRVEFVKLLIE------NG-------------------- --------------------VSMHKFLTIPRLEELYNTKQG------------------- ------------------------------------------------PTNPTLLHLVRD VK----------------------QGNLPPDYKIILIDVGLVIEYLMGGTYRCTYTRKRF RIIYNNLHGNN--RRSGRHSTGSG-PQLRKHQESLTNRADKKEKTR------HNHFIKTA QPYKPKPESSVDQGKRRKTKDEIVDIDD----------PETKRFPYPFNELLM------- -----WAVLM----------------------------KRQKM----------------- ----------------------------------------AMFFWQHGEES--------- -----MAKALVACKLNRSMSYEA-KQSD------------VVDDTSEELKQYSSEFGQLA VDL---LDQSF-RHDE-----------------------------------TMAMKLLTY -------------------------------ELKNWSNSTCLKLAVN-----SRLRPFVA HTCTQMLLSDMWMGRLNMRKNSW------------------------------------- ------------YKVILS-ILFPPTIL----------MLEF-KTKAEMSHIP-------- ------------------------------------QSEDAHQMNMEDSEHNF-QIPSDQ ------ISMDVFKEEGI-CDLHEMKQ---------------------------------- ----DDVP----------------LNKQRRLPI--------------------------- ----TRKFYYFYHAPIAKFW-------FN-------------TLAYLGFLMLYTY----- -----VVLVHM---------------------------------------KGSP------ ------------------------------------------------------------ --------------------------------------------------SFQEWIV-IS FIFTLAIEKIRELFM--------------------------------------------- ----------SEAG------------KINQKIKVY------FSDYFNITDTIAIILFFVG FGL-RFGTG----------------DILTAGRITY------------------------- ---CLNIIFWYVRLLDFL-AVNQHAGPYVTMIGKMVA-NMFYIVVIMAVVLLSFGVPRKA ILYPDKEASWEL---------------------------------------A-----KDI VFQPYWMIYGEVYAYE----------ID------------------------------PC ANNT--EEG---AKER------------------------------CVVGY--------- -WITPFLQAVYLFVQYILMVNLLIAFFNNVYFQVKAISNI------------VW------ ---KYQRYHFIMAYHEK----PVLPPPL-------------------------------- ----------------------------------------------------IILSHFAL LISHI----------------------------------CR-QGRK-----RDRGQGGPK LFL----------------------------------------SEEDQKK-L-------- -------------------------------HDFEE--QCVEKYFHEKEDR-FH-SGSEE -----------------------RIRVTSERVENMSIQ----------------LKEVGD --RVN-----------------------YIKRSLQSLDCQIGHLQ--------------- -----------------------------------DLS---------ALTVDTLKALTAQ -K-A-------------------------------------SEATKVHNEISRELSISRN LGE----------------------------NLAD---APLKSSLRKKHSIGTYFGSSFP QRVMDSGDSIGANGSLKDNVD-----------ASGRK--LGQDLLPSWQGNVLNVPEAGS SGC------ALLSNTGSPSELRHRSHLG-------------LGKTQSLNCDQMPGH---- --SFHSIP--NLSSPSAQFFVSTPSQPS---GKSQ------------------------- LEFVSDGDSADLPRKD---------------LDDDGSSVEFGAFVGHKDNLELPKSG--- -------------------------------------TREAITLKEKS------------ --AVGTIQNLDSLRPEYQLRTVNSYGGFAELYRDHL-KPGASVQAASLQGKSSK-NWMRA SAEDIRFHQEDLMASLLM----DRPDEK--SIASNCQMTTGEDALNAPHF---------- ---YSVQQS---QARQRKMG-------DIGSPFKPTLDVNYYYSA---VERNNLMRLSQT I--PFTP-VPNRGEPVTIYRLEESSPVSLNNSMSSWSQLGR-AAKIEFLSKEEM-----G GGLRRALKVECTW-----SECEILK-LG---------QLYI------VKSFLPEVVNTWT RIYKEDTVLHLCLREIQQQRAA-----QKLSFAFNQMKPKTIPYSPRFLEVF-LLYCHSA NQWF----AIEECMTGEF-----------------------RKFNHNSGDE--------- ----------------------------------------------------------IR PKNMLEETMLAFSHW--------------------------TYEYTR--GELLVLDLQGV G-------ENLTDP-SVIKAEEKRSYEMVFGPANLGEDAVKN-FRAKHRCNS----CC-- ----ARLKLPDI-----K------------------RNDYTP---DKV---------MLP QDDAPEVTVQSGS--------------GT-KDVRT--SIRLII----------------- ----- >Callorhinchus:milii_Elephant:fish_XP:007909973.1_NW:006890621.1_LOC103190877_TRPM1_Vertebrata_TRPM5:like 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-----------------------------------MK-DVFFFLFFLGIWLVAYGVTTQG LLHPGEARLSWI---------------------------------------F-----RRV FYRPYLQIFGQIPLNE----------IDAA----------------------FIS-TVNC TNDPISMVMD--DLPP------------------------------CINT--------YA NWLVIVLLVVFLLVANILLVNLLIAMFSYTFSKVQGNSDI------------YW------ ---KFQRYNLIVEYHKY----PALAPPF-------------------------------- ----------------------------------------------------IILSHINL IIKRN----------------------------------IRKVSSVK--------RKHFM MDL----------------------------------------SKLASSK-L-------- -------------------------------MTWEM--VQKENYLVNREKL-NR-ERDGE -----------------------RLKRTGQKVDNILKY----------------MTDIRE -----------------------------HERRLRILEEEVDYCT--------------- -----------------------------------NAL---------TWLVESLDQSDLI -K-S-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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>Callorhinchus:milii_Elephant:fish_XP:007884235.1_NW:006894676.1_LOC103173418_TRPM1_Vertebrata_TRPM5:like:partial ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MRFRA-------- ---------------------------RLEEHI--------------------------- ---STQ------KTGVG--------------------------------GRC-SIEIPVL CLLIQGQPY--------------------------------------------------- MLERIYKATQNN------------------------------------------------ -------------VP---------------------------------------WLVLAG SGGIADVLAEILQ-MS--------FTSE---------------TLKK-EVEKLIRKHFP- ---S-------------------------------------------------------- -----------ED----LARLVELVEKVVENK--------------------DLVYVYNA --------------------------DQEGME-----EFDT-----VILKALVKA----- ------HKKHS----SDVKVYLD-ELKLAVAWNRVDIAKS----------------ELFT GEISWK------------------------------------------------------ ------SSDLEDPLTDALV-NNKPEFVKLFTG------NG-------------------- --------------------LNVTDYLSYRRLEELYSSV--------------------- ------------------------------------------------PTNSLLNCLLQK KLVERRG--------LAGKLLTRPR-AGDGHCGYTLYEVSKVLCDLLGDFCQPIY----- ------------------------------------EESLHLSKVYS------------- 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------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000196689_Chr17_Vertebrata_TRPV1 ------------------------------------------------------------ ----------------------------------MKKWSS-------------------- --------------------------------TD-------------------------- -----LGAAADPLQKDTCPDPLD----------------------------GDPNS---- ---------------------------RPPPAKPQLSTAKSRTRLFG--------KGDSE EAF---------PVDCPHE---------------------------------------EG ELDSCPTITVS----PVITI-----------------------------QRPGD-G---- PTGARL----LSQDS----------------------------VAASTEKTLRLYDRRS- --------------IFEAVAQNNCQDLES------------------------------- ------------------------------------LLL--------------------- FLQ--------------------------------------------------------- -----------KSKKHLTDNEFK-----------------------DPET--GKTCLLKA ML---------------------------------------------------------- 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P--------------------------------------------------------VQL L--------QSN------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000167723_Chr17_Vertebrata_TRPV3 -------------------------------------------------------MKAH- --------------------PKEM-------VPLMGKRVAAPS---GNPAILP------- ----------------------EKRPAEI---TP-------------------------- -----TKKSAHFFLEIEG------------------------------------------ -------------------------------------------------------FEPNP TVAKTSPPVFSKPMDSNIR---------------------------------------QC ISGNCDDMDSPQS----------------------------------------P-QDDVT ETPSN---------------------------------PNSPSAQLAKEEQRRKKRRLKK -------------RIFAAVSEGCVEELVE------------------------------- ------------------------------------LLV--------------------- ELQELC------------------------------------------------------ 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FLL--------------------------------------------------------- -----------THKKRLTDEEFR-----------------------EPST--GKTCLPKA LL---------------------------------------------------------- -----NLSNGRNDTIP-VLLDIAER-----------------TGNMREFINS-------- ---------------------------PFRDIYY-------------------------- --RGQT----ALHIAIE------------------------------------RRCKHYV ELLVAQGADVHA--------------------------QARGRF---------------- -------FQPKDEG---------------------------------------------- ------------------GYFYFGEL----------------------------PLSLAA CTNQPHIVNYLTENP--------------------------------------------- ------------------------------------------------------------ --------HKKADMRRQDS-RGNTVLHALVAI---------------ADNTRENTKFVTK MYDLLLLKCA-------------RLFPDSNLE-----AVLN------------------- ------NDGLS-------------PLMMAAK----------------------------- ------------------------------------------------------------ --------------------TGKIGIFQHIIR---------------------------- 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------------------------------------LLL--------------------- DCTCDV------------------------------------------------------ ---------------------RQ-----------------------RGAL--GETALHIA ALY--------------------------------------------------------- ----DNL-----EAAL-VLMEAA-----------------------PELVFE-------- ---------------------------PTTCEAF-------------------------- --AGQT----ALHIAVV------------------------------------NQNVNLV RALLTRRASVSA--------------------------RATGTA---------------- -------FR-HSPR---------------------------------------------- ------------------NLIYFGEH----------------------------PLSFAA CVNSEEIVRLLIE----------------------------------------------- ------------------------------------------------------------ ---------HGADIRAQDS-LGNTVLHILIL--------------------QPNKTFACQ MYNLLLSYDG-------------HGDHLQPLD-----LVPN------------------- ------HQGLT-------------PFKLAGV----------------------------- ------------------------------------------------------------ --------------------EGNTVMFQHLMQ---------------------------- ----------------------------K------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-RHI------------------------------------Q------- -----WTYGP----------------------------LTSIL----------------- -------------------------------------------YDLTEIDS--------- --------------------------------------------WGEEL----------- ------------------------------------------------------------ ---------------------------------------SFLELVVS-SDKREARQ-ILE QTPVKELVSFKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NKYGRP------YFC-------IL-------------AALYLLYMICFTT----- ---------------------------------------CCVYRPL----KFRGGNRT-- ----------HSRDITIL------------------------------------------ -------------------------------------QQKLLQEAYETREDIIRLVGELV SIVGAVIILLLEIPDIFRVGAS-------------------------------------- ----------RY-------------------FGKT------ILGGPFHVIIITYASLVLV TMV-------------------MRLTNTNGEVVPM------------------------- ---SFALVLGWCSVMYFT-RGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYI IFQTED--------------------------------------PTS-LGQF------YD YPMALFTTFELFL-------TVI-----------------------------DAPANYD- ---------------------------------------------------------VDL PFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDE------------LW------ ---RAQVVATTVMLERK------LPRCLWPRSGI--------------CGCEFGLG---- -----------------------------------------------------DRWFL-- --------------------------------------------------------RVEN ------------------------------------------------------------ ----------------------------------------------HNDQN-PL-R---- -----------------VLRYVEVFKNSDKEDDQEHP----------------------- -----------------------------SEKQ--------------------------- --------------------------------------------------PSGAESG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLARASL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ALPTSSLSRT ASQSSSHR------------------------------------------GWEILRQNTL ------------------------------------------------GHLNLG------ --------------------------------------------------------LNLS EG----D--------------------------------------------GEE-V-YHF ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Homo:sapiens_Human_ENSG00000165125_Chr7_Vertebrata_TRPV6 ------------------------------------------------------------ ----------------------------------MGPLQGDGGPALGGADVAP------- ------------------------------RLSP-------------------------- -----VR----------------------------------------------------- -------------------------------------------------------VWPRP QAPK-EPALH--PMGLSLPK----------------------EKGLILCLWSKFCR---- WFQRRESWAQSRDEQNLLQQ-----------------------------KR--------- -----------IWES-----------------------P--------------------- --------------LLLAAKDNDVQALNK------------------------------- ------------------------------------LLK--------------------- YEDCKV------------------------------------------------------ ---------------------HQ-----------------------RGAM--GETALHIA ALY--------------------------------------------------------- ----DNL-----EAAM-VLMEAA-----------------------PELVFE-------- ---------------------------PMTSELY-------------------------- --EGQT----ALHIAVV------------------------------------NQNMNLV RALLARRASVSA--------------------------RATGTA---------------- -------FR-RSPC---------------------------------------------- ------------------NLIYFGEH----------------------------PLSFAA CVNSEEIVRLLIE----------------------------------------------- ------------------------------------------------------------ ---------HGADIRAQDS-LGNTVLHILIL--------------------QPNKTFACQ MYNLLLSYDR-------------HGDHLQPLD-----LVPN------------------- ------HQGLT-------------PFKLAGV----------------------------- ------------------------------------------------------------ --------------------EGNTVMFQHLMQ---------------------------- ----------------------------K------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-KHT------------------------------------Q------- -----WTYGP----------------------------LTSTL----------------- -------------------------------------------YDLTEIDS--------- --------------------------------------------SGDEQ----------- ------------------------------------------------------------ ---------------------------------------SLLELIIT-TKKREARQ-ILD QTPVKELVSLKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KRYGRP------YFC-------ML-------------GAIYLLYIICFTM----- ---------------------------------------CCIYRPL----KPRTNNRT-- ----------SPRDNTLL------------------------------------------ -------------------------------------QQKLLQEAYMTPKDDIRLVGELV TVIGAIIILLVEVPDIFRMGVT-------------------------------------- ----------RF-------------------FGQT------ILGGPFHVLIITYAFMVLV TMV-------------------MRLISASGEVVPM------------------------- ---SFALVLGWCNVMYFA-RGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYI IFQTED--------------------------------------PEE-LGHF------YD YPMALFSTFELFL-------TII-----------------------------DGPANYN- ---------------------------------------------------------VDL PFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDE------------LW------ ---RAQIVATTVMLERK------LPRCLWPRSGI--------------CGREYGLG---- -----------------------------------------------------DRWFL-- --------------------------------------------------------RVED ------------------------------------------------------------ ----------------------------------------------RQDLN-RQ-R---- -----------------IQRYAQAFHTRGSEDLDKDS----------------------- -----------------------------VEK---------------------------- -----------------------------------------------------LELG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CPFSPHL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SLPMPSVSRS TSRSSAN--------------------------------------------WERLRQGTL RRD-------------------------------------------LRGIINRG------ --------------------------------------------------------LE-- ------D--------------------------------------------GESWE-YQI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:005999492.1_NW:005819538.1_Vertebrata_TRPV1_TRPV4 ------------------------------------------------------------ ----------------------------------MGDVEEQNKLNSSGDANDT------- ---------------------RTEDGSQQNDAFP-------------------------- -----LSSLANLFENEEGATATDTAKA--------------------PQTAGDG-KQN-- ----------------LRMKFHGAFKKGMPNPMDLLESTIYESPV-----------VPAP KKA---------PMDSLFD---------------------------------------YG TYHQYPTENKRRR--KRIIH-----------------------------DK-QS-PNQKT QAPN----------------------------------P--PPI-------LKVFNRPI- --------------LFDIVSRGTAAELDG------------------------------- ------------------------------------LLA--------------------- FLV--------------------------------------------------------- -----------THKKRLADEEFR-----------------------EPST--GKTCLPKA LL---------------------------------------------------------- -----NLTNGKNDTIP-ILVEIAEK-----------------TGNLREFINS-------- ---------------------------PFRDVYY-------------------------- --RGQT----ALHIAIE------------------------------------RRCKQYV ELLVEKGADVHA--------------------------QARGRF---------------- -------FQPRDEG---------------------------------------------- ------------------GYFYFGEL----------------------------PLSLAA CTNQPDIVHYLIENA--------------------------------------------- ------------------------------------------------------------ --------HKKADLRRQDS-RGNTVLHALVAI---------------ADNTRENTKFVTK MYDMLLIKCA-------------KLFPECNLE-----AILN------------------- ------NDGMS-------------PLMMAAK----------------------------- ------------------------------------------------------------ --------------------LGKIGIFKYIIR---------------------------- ----------------------------REVMDE---NAR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HLSR-KFK------------------------------------D------- -----WAYGP----------------------------VYSSL----------------- -------------------------------------------YDLSSLDT--------- --------------------------------------------CGMEV----------- ------------------------------------------------------------ ---------------------------------------SVLEILVY-NSRIENRHEMLA VEPINELLRDKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RKFGAV------SFY-------IS-------------VVSYLVAMVIFTL----- ---------------------------------------IAYYRPVEGR-PPYP-YKT-- ------------------------------------------------------------ ------------------------------------------------TIDYLRLAGEVI TLLTGIFFFFTNIKDLFLKKC--------------------------------------- ----------PG-------------------VNSL------LIDGSFQLLYFIYSVLVLV TAA-------------------LYLTGIEAYVAVM------------------------- ---VFALVLGWMNTLYFT-RGLKLTGTYSIMLQKILFKDLFRFLLVYVLFMIGYASALVS LLNPCLT-----------------------TETC--TANNASC---T-APEYPYCRDSNT FGKFIMDLFKLTI-------GMG-----------------------------DLEMVNS- ---------------------------------------------------------AKY PGVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQ------------IW------ ---KLQWATTILDIERS------FPVFLRRVFR---------------SGEMVTVGKN-- ----LDGTPD-------------------------------------------RRWCF-- --------------------------------------------------------RVDE V------------------------------------------------N-W-------- -------------------------------SHWNQ---NL--GIINEDPG-KN-E---- -----------------TYQY-YGFSHTMGR----------------------------- -----------------------------LRR---------------------------- ---------------------------------------------------DRWST---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VVPR--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VVELN---- KTPRADEV---------------------------------------------VVSLDPM --------------------------------------GMSNVHDTKRGDPHN------- ----------------------------------------------------------WK K------------------------------------------------------DETQI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:006010862.1_NW:005821475.1_Vertebrata_TRPV1_TRPV3 -------------------------------------------------------MEDS- --------------------AAEG-------ILLMERAGSNIS--IDNETIVP------- ----------------------LQDHSE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------EMDSEDD---------------------------------------KC ------------------------------------------------------------ ---SN---------------------------------P--------------KETRIGE --------------LSEAICDGSLEKVKA------------------------------- ------------------------------------ILN--------------------- EL---------------------------------------------------------- --------------PSKTFEEFK-----------------------VSAN--GQTYLMKA LL---------------------------------------------------------- -----NFNEKTKETVE-LLLTFAED-----------------NGFLKVLINA-------- ---------------------------EYENGDY-------------------------- --KGQT----ALHIAIE------------------------------------RRCKDIV KLLLNKGADVDA--------------------------KACGDF---------------- -------FNPKMNM---------------------------------------------- ------------------DGFYFGET----------------------------PLALAA CTNQLEIVQMLLE----------------------------------------------- ------------------------------------------------------------ ---------KGSDTGFQDS-RGNTVLHALVEV---------------ADDSENYINSIKQ IYEEILTKHE-----------------GENLE-----AVTN------------------- ------NKNLT-------------PVHLAAQ----------------------------- ------------------------------------------------------------ --------------------RGKRWILKYILE---------------------------- ----------------------------RELKDK---KTR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------NLSR-KHT------------------------------------T------- -----WAYGP----------------------------VSSSV----------------- -------------------------------------------YDLTGLDA--------- --------------------------------------------D-QDI----------- ------------------------------------------------------------ ---------------------------------------SVLKLIVY-NSEIPERHEMLA LEPLNTVLCMKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EKFASK------MFS-------IS-------------FLFYFTYNVILTL----- ---------------------------------------ISYYRPNRDK-FPVPLDLS-- ------------------------------------------------------------ -----------------------------------------------RHSGRLHFSGQVF VFICAIYLMIKESIELILLRP--------------------------------------- ----------SD-------------------LKIV------LSDAWFHITFFLQAALIIV SSI-------------------MCWSSLKECVIVL------------------------- ---VLGLSLGWINMLYYT-RGFETLGIYSVMVQKVILNDVLKFLLVYALFLLGFGVALAS LVNTCP--------------------------------DNNDC------SPY------SS YHTTVLELFKLTL-------GLG-----------------------------DLELQKH- ---------------------------------------------------------SLY PELFLALLVLYVLLTFVLLLNMLIALMGETVEELSKKSKN------------IW------ ---KLQRARTILDLERR------LPPYFRKKFR---------------IGQFYHF----- -------NDN-------------------------------------------HRWCI-- --------------------------------------------------------RINE L------------------------------------------------N-W-------- -------------------------------TEFNT---SV--ACTEEDPA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K KEHNGST-----------------------------------------------RRMSPL ------------------------------------------------------------ -----------------------------------------------------------L P------------------------------------------------------EESS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XP:014354450.1_NW:005822807.1_Vertebrata_TRPV1_TRPV1_partial ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------M-LLFSIL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AFFAGEF----------------------------PLSLAA CTNQLDIVTFLLENK--------------------------------------------- ------------------------------------------------------------ --------YHRADIRKQDS-IGNTVLHALVMV---------------SDNTKESTNFVTK MYDEILMMGM-------------KVDLNLKLE-----EYKN------------------- ------NQGLT-------------PLKVAAK----------------------------- ------------------------------------------------------------ --------------------TGKIGLFKHIIR---------------------------- ----------------------------REIKKE---GCK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HLSR-KFT------------------------------------E------- -----WAYGP----------------------------VHSSL----------------- -------------------------------------------YDLSAVDS--------- --------------------------------------------F-EEN----------- ------------------------------------------------------------ ---------------------------------------SVLEIIVY-NSENQNRHDLLL VEPLNNLLQEKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DKYAAK------LFY-------CD-------------CFIYTAYMIIFTL----- ---------------------------------------VAYHRPLEGK-PPFP-IKQ-- ------------------------------------------------------------ -----------------------------------------------NTEGYLRLTGQII TMLGGLLFFIKGIVYFISKR---------------------------------------- ----------PS-------------------LTSL------LIDGYCDVLFFIQGLFLLA SGV-------------------VYTAGREEYIGFM------------------------- ---VVSLAMGWVNILYYT-RGFQHMGIYGVMIQRMILSDLFRFLFVYMMFLFGFAA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XM_014491642.1_LOC102353392_Vertebrata_Paper2020_TRPV5/6 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MGI-------------------------------------------- ------------------------------------------------------------ -----------IQEN-----------------------P--------------------- --------------LFQAAKDNDIRAMKK------------------------------- ------------------------------------ILT--------------------- CPCTDI------------------------------------------------------ ---------------------YK-----------------------R------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --AGQT----ALHIAVV------------------------------------KQNMNLV KEMIKKGADVVTP-------------------------RATGAY---------------- -------FR-RSRR---------------------------------------------- ------------------NLIYFGKX----------------------------ILSFAA CTGNEEIVRLLIE----------------------------------------------- ------------------------------------------------------------ ---------HGANIRAQDY-LGNTVLHILVL--------------------QPNKTIACQ LFDMIMSYD--------------QGENGVTTD-----MIPN------------------- ------HKGLT-------------PFKLAAM----------------------------- ------------------------------------------------------------ --------------------EGNVVIFQHLIQ---------------------------- ----------------------------K------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------K-KRV------------------------------------Q------- -----WCFGP----------------------------VTSTI----------------- -------------------------------------------YDLSGIDS--------- --------------------------------------------WGDDL----------- ------------------------------------------------------------ ---------------------------------------SVLELVVC-SQKKEVR----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GHEQCSLW------------------------------------------ -------------------------------------MILSLKECYLTRDDQLRLVGEII TVIGALVILLLEIPDMLRIGPT-------------------------------------- ----------RF-------------------FGQT------ILGGPFHVIMILYAGLVLV ILI-------------------VRLTSSDGERVLM------------------------- ---SFGLLLGWCNILYFA-RGFPMLGPFTIMIQKMIFGDLLRFCWLMLMVIFAYTSAFHM TFQTQD--------------------------------------PTS-APEF------QD YSMTLLTTFQLFL-------GLL-----------------------------DIPINYE- ---------------------------------------------------------AYV PAIVKILYVSYMILAFLLMVNLLIAMMGDTHWRVAHERDE------------LW------ ---RAQ--------QRT------FPSATGPAE----------------CSFQNILF---- -----------------------------------------------------TLFFFFF -----------------------------------------------------PPHRVED ------------------------------------------------------------ ----------------------------------------------RYDHA-VQ-K---- -----------------IRRYAKAFRDQDRCREGKAQ----------------------- -----------------------------EKE---------------------------- --------------------------------------------------DPELQYQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---NTFRP---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LGENEPPKE SAR-----------------------------------------------GWQILRRTSM ------------------------------------------------TLLHKE------ --------------------------------------------------------LK-- ------D--------------------------------------------AAQEEIYQV F--------MGITD-----------------ADE-------------------------- ------------------------------------------------------------ ----------------------------G-YPM--------------------------- ----- >Lepisosteus:oculatus_Spotted:gar_XP:006641065.1_LG22_Vertebrata_TRPV1_TRPV1 ------------------------------------------------------------ ----------------------------------MSRFCTP------------------- ----------------------EEDKSESTEETI-------------------------- -----LSLETDDTQSE------------------------------------DGRS---- ---------------------------QTSKGKKGLLSSA-----FG-----I--IGSAE NRV---------PMDTGYQ---------------------------------------ED ITEPKPKVKFNLNFDKKVRG-----------------------------EAEGE-GKRQT PAGK--------------------------------------------------FDMKK- --------------LFEAVASGEVKQLDG------------------------------- ------------------------------------LEE--------------------- YLR--------------------------------------------------------- -----------QTMKRLTNSEFK-----------------------DPSN--GKTALLKG LL---------------------------------------------------------- -----NLKEGHNDTIM-VLLNIAEK-----------------TGNLEDFINA-------- ---------------------------AYTDSYY-------------------------- --KGQS----ALHIAIE------------------------------------RRSMHFV KCLIQKGANVHA--------------------------RACGKF---------------- -------FQLNRG----------------------------------------------- ------------------SGFYFGEL----------------------------PLSLAA CTNQLEVVAFLMENP--------------------------------------------- ------------------------------------------------------------ --------YQSVKVTESDS-MGNTVLHALVVV---------------ADDTPESTRFVTK MYDEILMRAA-------------KLHPKVKLE-----DVTN------------------- ------NQGLT-------------PLKLAAR----------------------------- ------------------------------------------------------------ --------------------TGKLGLFKHIVR---------------------------- ----------------------------REIKDS---ECR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HLSR-KFT------------------------------------E------- -----WAYGP----------------------------VHSSL----------------- -------------------------------------------YDLASLDS--------- --------------------------------------------Y-EPN----------- ------------------------------------------------------------ ---------------------------------------SVLQIIVY-GSEIPNRHELLQ VEPLNKLLQEKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DRFASK------MFF-------FN-------------FFVYVIYLSIFTT----- ---------------------------------------VAYFR-LEGK-PPFP-LEH-- ------------------------------------------------------------ -----------------------------------------------STKGYLRLTGQLI GVSGAIYFFYNGIVDFKRKR---------------------------------------- ----------PK-------------------LESL------LIDGYCEILFFLQAVFFLT SSV-------------------LYTCGRQEYVAFL------------------------- ---VISLALGWVNLLYFS-RGFQHLGIYSVMIQKMILGDILRFLFVYIVFLFGFSAAIVT LLEEQPAPPLSGNGT---APNGTGTGTGTGTEPNP-TPGNPAD-DCK-KQSY------NN FYYTTLELFKFTI-------GMG-----------------------------DLEFTEQ- ---------------------------------------------------------YRF KKVFYFLLISYIILTYILLLNMLIALMSETVERISRDSKS------------IW------ ---KLQRAITILDLEKS------LPSCLRAKLR---------------SGVPRELGRS-- ----PG--DD-------------------------------------------CRRCF-- --------------------------------------------------------RVEE V------------------------------------------------N-W-------- -------------------------------NTWNL---NL--GIINEDPG-NE-P---- -----------------QEISTITPAEAGPR----------------------------- ------------------------------RA---------------------------- ---------------------------------------------------RSWRN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----IVPI--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LRDFNQART QSPQEEE----------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------MR P----------------------------------------------------------I S--------SSPH----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006640397.1_LG20_Vertebrata_TRPV1_TRPV4 ------------------------------------------------------------ ----------------------------------MTEPEDAS--GPVGSGSGD------- ---------------------SGDSPQENDSSFP-------------------------- -----LSSLANLFEGEEGSPAPEL-----------------------PR-PGES-RQN-- ----------------LRMKFQGAFKKGITNSMDLLESSIYESPV-----------VPAP KKA---------PMDSLFD---------------------------------------YG TYHQ-PNNQKRRR--KKIPN-----------------------------SKLAA-ASVKG PAPD----------------------------------P--PPV-------LKVFNRTM- --------------LFDAVSRGDTSALQG------------------------------- ------------------------------------LLQ--------------------- FLQ--------------------------------------------------------- -----------CNKKRLTDEEFR-----------------------EPST--GKTCLPKA LL---------------------------------------------------------- -----NLYSGQNDTIP-FLVDIAEQ-----------------TGNLREFINT-------- ---------------------------PFRDVYY-------------------------- --RGQT----ALHIAIE------------------------------------RRCKQYV ELLVEKGADVHA--------------------------QARGRF---------------- -------FQPKDEG---------------------------------------------- ------------------GYFYFGEL----------------------------PLSLAA CTNQPDIVHYLTENS--------------------------------------------- ------------------------------------------------------------ --------QKKADLRRQDS-RGNTVLHALVHI---------------ADNTRENTRFLTK MYDLLLIKSV-------------KLYPDCNLE-----TVLN------------------- ------NDSMS-------------PLMMAAK----------------------------- ------------------------------------------------------------ --------------------LGKIGVFQHIIR---------------------------- ----------------------------REIKDE---NAR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HLSR-KFK------------------------------------D------- -----WAYGP----------------------------VYSSL----------------- -------------------------------------------YDLSSLDT--------- --------------------------------------------CGEEV----------- ------------------------------------------------------------ ---------------------------------------SVLEILVY-NSRIENRHEMLA VEPINELLRDKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QKFGAV------TFY-------IS-------------VVSYLVAMVIFTL----- ---------------------------------------VAYYRPSEGT-PPYP-YST-- ------------------------------------------------------------ ------------------------------------------------SSEYLRMAGEIV TVFTGVFFFLTNIKDLFLKKC--------------------------------------- ----------PG-------------------VNSL------FIDGSFQLLYFIYSVLVLV TAA-------------------LYLSGIKAYVSVM------------------------- ---VFALVLGWMNTLYFT-RGLKLTGTYSIMIQKILFKDLFRFLLVYVLFMIGYASALVC LLH-----------------------------SC--PGPDAQCPEGK-CPTYPQCRDTDT FSTFLLDLFKLTI-------GMG-----------------------------DLDMINS- ---------------------------------------------------------TQY PAVFLILLVTYIILTFVLLLNMLIALMGETVGQVSKESKK------------IW------ ---KLQWATTILDIERS------FPVCLRRTFR---------------SGEMVTVGKN-- ----SDGTPD-------------------------------------------RRWCF-- --------------------------------------------------------RVDE V------------------------------------------------N-W-------- -------------------------------SHWNQ---NL--GIINEDPG-KN-E---- -----------------TYQY-YGISQTVRG----------------------------- -----------------------------LRR---------------------------- ---------------------------------------------------DRWST---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VVPR--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------AVELH---- KHPRSGEA---------------------------------------------VVEMEQF EPLNPG--------------------------------NRPS-----RETPNR------- ----------------------------------------------------------F- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Lepisosteus:oculatus_Spotted:gar_XP:006642484.1_LG26_Vertebrata_TRPV1_TRPV5 ------------------------------------------------------------ ----------------------------------MPP----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PLALTAP-------------------------GQIGHWWSRLRF---- RLQHKKDWTQVLDETFLLQS-----------------------------KR--------- -----------IKDS-----------------------P--------------------- --------------LFFAAKENDVMSIRK------------------------------- ------------------------------------LLK--------------------- CPSTDI------------------------------------------------------ ---------------------FE-----------------------RGAL--GETALHVA VMF--------------------------------------------------------- ----DNL-----EASV-ALIEGV-----------------------PDLINE-------- ---------------------------PMSSDVY-------------------------- --EGMT----AMHIAVL------------------------------------NQNVNLV RELIARGADVATP-------------------------RVTGSY---------------- -------FK-KRRK---------------------------------------------- ------------------GLVYFGEH----------------------------ILCFAS CVGNEEIVNMVIE----------------------------------------------- ------------------------------------------------------------ ---------AGANLRAQDY-LGNTVLHILIL--------------------QPNKMISCQ IFDLLMAADG-------------KTDRGVPLD-----VLPN------------------- ------FRGLT-------------PFKLAAK----------------------------- ------------------------------------------------------------ --------------------EGNVVMFQHMVS---------------------------- ----------------------------K------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-RSL------------------------------------Q------- -----WSLGP----------------------------LSSYL----------------- -------------------------------------------YDLSEIDS--------- --------------------------------------------WSDDC----------- ------------------------------------------------------------ ---------------------------------------SVLELVVC-SSKREARR-ILD VSPVRQLVSLKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NLYGKH------YFR-------FL-------------LLLYLLYIGTFTL----- ---------------------------------------CCTFRPL----KPIPENYSL- ----------EHTDITIF------------------------------------------ -------------------------------------VQKTLEESYISYEDHLRLVGEII SVVGALVILLLEIPDILRVGAK-------------------------------------- ----------RY-------------------FGQT------VLGGPFHVILITYACLVLV LLI-------------------LRLSSSEGEAVVM------------------------- ---ALSLVLGWCNVMYFA-RGFEMLGPYVIMIQKIIFGDLTKFIWLSVLVLVGFSTALWM TYMTFD--------------------------------------YTQGIPSY------KS FPVSLFSQFELSM-------GMI-----------------------------DLPVDQT- ---------------------------------------------------------VPT PPIVHILHIMFSVVSCLLLLNLLIAMMSDTHWRVAQERDE------------LW------ ---RAQVVATTIMLERR------LPRCMWPQMGI--------------CGQEYGLG---- -----------------------------------------------------DRQYL-- --------------------------------------------------------RVED ------------------------------------------------------------ ----------------------------------------------HRSQA-MK-K---- -----------------IWHYANAFLEKGEGLGEKEQ----------------------- -----------------------------GRE---------------------------- ---------------------------------------------------TDLSAGR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VVFR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SRQ KGRTMLNRK--------------------------------------SLGAWEMIRRSAL GSE--------------------------------------------HGLTNL------- ------------------------------------------------------------ ------D--------------------------------------------AVEVE-LNV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007894726.1_NW:006890100.1_Vertebrata_TRPV1_TRPV1 ------------------------------------------------------------ ----------------------------------MRRMDN-------------------- -----------------------EDPSEATETTT-------------------------- -----VNADTDHVFTE------------------------------------DESSDN-- ----------------ALGHESGGEVWEIPHGFKAMKRTAHRYH-FG-----LREFEGSK TKV---------PMDSFY------------------------------------------ ------SIDYQLS----------------------------------------------- PKDSRF----GSQDSVWS--------------GKNQAFR--PPVSSETDSSPSIYNRHW- --------------LFEMVSKGTAKELDG------------------------------- ------------------------------------FEE--------------------- HLM--------------------------------------------------------- -----------RNKKYLTDWEYK-----------------------DPET--GKTALLKA LL---------------------------------------------------------- -----NLNNKKNDTVS-RLLEIAEK-----------------GNNLKEFINA-------- ---------------------------AYTDSYY-------------------------- --RGQT----ALHVAIE------------------------------------RRSAHFV ELLVRNGADVHA--------------------------RASGIF---------------- -------FKQKKSG---------------------------------------------- ------------------DGFYFGEL----------------------------PLSLAA CTNQLDIVTFLLENP--------------------------------------------- ------------------------------------------------------------ --------HSRADVSAVDS-RGNNVLHALVAV---------------ADNTPENTKFVTK MYNGLLMKSV-------------KIRPLENLE-----ATTN------------------- ------KKGLT-------------PLKLAAK----------------------------- ------------------------------------------------------------ --------------------TGKLQLFKDIMG---------------------------- ----------------------------REVQEE---ECR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HLSR-KFT------------------------------------E------- -----WAYGP----------------------------VHSSL----------------- -------------------------------------------YDLSSLDT--------- --------------------------------------------D-DEQ----------- ------------------------------------------------------------ ---------------------------------------SVLEIIVH-GTKNEFRHEMLL VEPLNKLLQEKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NKFARF------IFC-------VD-------------FFIYFAYMTVFTL----- ---------------------------------------VGYNRKENMT-LPFP-IEH-- ------------------------------------------------------------ -----------------------------------------------TTEGYLRLTGQII TLLGAFYLFFTGIHTVIFRRMF-------------------------------------- --------RGKS-------------------VKPI------TVDSYCDILSFVQSLMLLA SAL-------------------LYTTGRNEYVGFM------------------------- ---VIAMALGWINTLYYS-RGFYRMGVYSVMVQKILVTDILRFLIVYIVFLFGFGVALVT LIEEGP----PKGRM---ATSQKNYRLLSKTE--------CVC-DSG-YNTY------KD LYSTFLELFRFTI-------GMG-----------------------------DLEFTED- ---------------------------------------------------------YKF KEVFILLLISYVILTYILLLNLLIALMSQTVEKISKDSKN------------IW------ ---KLQRAVTILDLERS------LPRCLRDRLR---------------SGESVVVGMT-- ----PDNKED-------------------------------------------MRRCY-- --------------------------------------------------------RIDE V------------------------------------------------N-W-------- -------------------------------TKWNT---NL--GLINEDPG-NS-N---- -----------------VIRRSSLARNSRFR----------------------------- -----------------------------RGE---------------------------- ---------------------------------------------------SGWQS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MLPL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LREMKTEKQ EEIESHE-------------------------------------------------MDTL -----------------------------------------------TGRRRRK------ --------------------------------------------------------LSVT P------------------------------------------------------KDV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007900044.1_NW:006890144.1_Vertebrata_TRPV1_TRPV4 ------------------------------------------------------------ ----------------------------------MARPEGKDSGRVNNSSIEN------- ---------------------VEEEGPPASESFP-------------------------- -----LSSLANLFENDESNSTLEVSRGA-------------------LRENGESNKQN-- ----------------LRAKFHGAFKNRMPNPMDLLESSIYDSSIPS--------MAPAP KKA---------PMDSLFD---------------------------------------YG TYRQ-SSDEKRKR--KKLPK-----------------------------DK--A-PKVKP PAPD----------------------------------P--PPV-------LKVFNRVL- --------------LFDIVSRGVVSELDG------------------------------- ------------------------------------LLS--------------------- FLL--------------------------------------------------------- -----------SQKKRLTDEEFR-----------------------EPST--GKTCLPKA LL---------------------------------------------------------- -----NLNNGKNDAIP-VLLEIAEK-----------------TGNLREFINA-------- ---------------------------PFRDVYY-------------------------- --RGQI----ALHIAIE------------------------------------RRCKHYV ELLVEKEVDVHA--------------------------QARGKF---------------- -------FQPKDEG---------------------------------------------- ------------------GYFYFGEL----------------------------PLSLAA CTNQPDIVHYLTENP--------------------------------------------- ------------------------------------------------------------ --------HKVADLRRQDS-RGNTVLHALVAI---------------ADNTRENTKFLTK MYDLLLIKCA-------------KLYPDCNLE-----VILN------------------- ------NDGLS-------------PLKMAAK----------------------------- ------------------------------------------------------------ --------------------LGKIGIFQHIIR---------------------------- ----------------------------REIKDE---SAR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------HFSR-KFR------------------------------------D------- -----WAYGP----------------------------VSSSL----------------- -------------------------------------------YDLSAIDT--------- --------------------------------------------CGEEV----------- ------------------------------------------------------------ ---------------------------------------SLLEILVY-NGKIENRYEMLA VEPINELLRDKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KKFAAV------SFY-------LS-------------VISYLTAMVIFTL----- ---------------------------------------IAYYRPSDGK-PPYP-YNT-- ------------------------------------------------------------ ------------------------------------------------TADFMRMGGEII TVVTAIFFFFTNVKDLFLKKC--------------------------------------- ----------PG-------------------VNSM------FIDGSFQLLYFIYSILVLV SAG-------------------LYLAGEESYLGVM------------------------- ---VFALVLGWINTMYFT-RGLKLTGTYSIMIQKILVKDLFRFLLVYLLFMIGFTSALVS LLVTCPI---------------------NEFEICDITSDSPNC---T-SSTYPICRDNLS FSKFLLELFRLTI-------GMG-----------------------------DLDVINS- ---------------------------------------------------------AKF PIVFVILLVSYIILTFVLLLNMLIALMGETVGQVSKKSKQ------------IW------ ---KLQWATTILDVERS------FPICLRKAFR---------------SGEMVTVGIN-- ----SDGTPD-------------------------------------------RRWCF-- --------------------------------------------------------RVDE V------------------------------------------------N-W-------- -------------------------------SHWNQ---NV--GIINEDPG-RN-D---- -----------------IYQFDGGINQTMGR----------------------------- -----------------------------LRR---------------------------- ---------------------------------------------------DRWST---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VVPR--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VVELN---- KPSRADEY---------------------------------------------VVGMEHI ----SM--------------------------------DHPRERKYGYGQSQRN------ --------------------------------------------------------IHWK R------------------------------------------------------AESHI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007894728.1_NW:006890100.1_Vertebrata_TRPV1_TRPV3 M------------------------------------------------------IKFR- --------------------ARRE-------LRMMDK----------NLRVL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LATEVD---------------------------------------SC -----------------------------------------------------------T PDPCN---------------------------------E-------MKIKQRKLQNRVWV -------------DFYRSIAEGDLGEFDK------------------------------- ------------------------------------FLQ--------------------- LFQ--------------------------------------------------------- -----------ESKTKLTAEWLR-----------------------DPRT--GKTCLMKA LL---------------------------------------------------------- -----NLNDNTQEMVE-KLISFAEA-----------------SDSLEQLINA-------- ---------------------------EYTDREY-------------------------- --KGQT----ALHIAIE------------------------------------RRCKTIV QLLVEKGADINA--------------------------KAQGRF---------------- -------FKPKKLK---------------------------------------------- ------------------HGFYFGEL----------------------------PLSLAA CTNQPDIVTLLMA----------------------------------------------- ------------------------------------------------------------ --------SGRTDVRAQDA-WGNCILHALVTV---------------ADDSEDNTTFVTE MYDMILMSSQ-----------------DHNLE-----GICN------------------- ------LRGLN-------------PLQLAAK----------------------------- ------------------------------------------------------------ --------------------LGKFKIFSHILC---------------------------- ----------------------------REFKDK---KHL-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------NLSR-KIT------------------------------------D------- -----WAYGP----------------------------VSSSL----------------- -------------------------------------------YDITEVDT--------- --------------------------------------------N-HQN----------- ------------------------------------------------------------ ---------------------------------------SVLEIVVH-NTKIQNRHELLS VEPLNTLLEEKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LTFGAH------MFT-------IT-------------CIVYVLYIIGFTT----- ---------------------------------------VYYNQAERYQ-SLISENLT-- ------------------------------------------------------------ -----------------------------------------------STTS-LQLFGEIS SFTAAWVVIIKEGLVLVRLRP--------------------------------------- ----------SD-------------------LRSI------VTDAWFHILFFLQALMTAS SAV-------------------LCWARVEAHLLLL------------------------- ---VPALALGWINILYFT-RGFKSMGIYSVILQKVLLTDVLLFLFVYLLFLIGFSVALAS LIDSCP--------------------------------NSLEC------SPY------LT FNTVILELFKLTL-------GLG-----------------------------DLQIQQH- ---------------------------------------------------------AKY PQLFLLLLGVYVVLTFVLLLNMLIALMSETVEDTAKESKN------------IW------ ---KLQRARMILNLERS------LPKCLRRRFQ---------------LGTILKNS---- -------QGH-------------------------------------------SRRYI-- --------------------------------------------------------RINE V------------------------------------------------N-W-------- -------------------------------TKWKT---SV--ARIHEDPG-NE-E---- -----------------EEQEDKSSDEVEHKICPGTTLQ--------------------- ----------------------------SVQT---------------------------- ---------------------------------------------------TSGPSDS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EKEEPR--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CKRIGKLRI KAKNMNT-----------------------------------------------LHSEAV LEQ--------------------------------------------------------- ---------------------------------------------------------ETY PL----------------------------------------------------QEPSNT T--------Q-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Callorhinchus:milii_elephant:fish_XP:007886998.1_NW:006890063.1_Vertebrata_TRPV1_TRPV6 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MPGFLS-------------------------GRGREILSRFARELSC RLQPGKELQDRIDKLHLLQN-----------------------------QR--------- -----------ISET-----------------------P--------------------- --------------LFLAARENDVDAVKT------------------------------- ------------------------------------LLE--------------------- CPTVDL------------------------------------------------------ ---------------------FE-----------------------KGVM--GETALHVA VLY--------------------------------------------------------- ----NNC-----EVAT-ELLEAA-----------------------PELINV-------- ---------------------------PVTSQMY-------------------------- --EGET----ALHIAVA------------------------------------NENVSLV RELIGRGADVVTA-------------------------RATGTF---------------- -------FR-RNAK---------------------------------------------- ------------------KLFHFGEH----------------------------VLSFAA CVGNEGIVRILIE----------------------------------------------- ------------------------------------------------------------ ---------NGADIKAQDS-LGNTVLHHLVL--------------------Q-TQTKVTE MFDLILSLE---------------PKDGATVE-----TMTN------------------- ------QAGLT-------------PFKLAAQ----------------------------- ------------------------------------------------------------ --------------------EGNVQLFQHLLR---------------------------- ----------------------------K------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RERRL------------------------------------Q------- -----WFFQS----------------------------VSTTF----------------- -------------------------------------------YDISGIDS--------- --------------------------------------------WDDNC----------- ------------------------------------------------------------ ---------------------------------------SVLDLVVF-SKEIEALK-ILD LHPIKELVSFKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NRYGKY------YFR-------CL-------------SVLYLLYIIIFTL----- ---------------------------------------CCTFRPL----IPRPEVVT-- ----------DPEDTQLL------------------------------------------ -------------------------------------VEAPLKLCYVSTKDQVRLVGELI SVFGAIAILFIEISDMVRYGVS-------------------------------------- ----------GY-------------------FGKT------VYGGPFHAINICYACLVLL ILV-------------------LRLSSAGSEGIFM------------------------- ---SLAMVLAWCNFIHFA-RGFQTLGTFSILIHKIVLENLMPYLFLMLIIIVGFTTGLYV IFQELD--------------------------------------PKK-WVYF------DG FKNEMFLMFMLFF-------GLL-----------------------------DIPLNYE- ---------------------------------------------------------VYT PYMIKVLYVAYIMMTFQMMAILLINLIAGTLRRVVPNRNR------------IY------ ---RAQVIASTLHLERR------LPRLLWPRAGT--------------WGEKVGLD---- -----------------------------------------------------NSWYI-- --------------------------------------------------------WVED ------------------------------------------------------------ ----------------------------------------------RNDKP-AP-SNSRD -------------LTTGESRAAGDWTRTGRAVQPQAD----------------------- -----------------------------GRK---------------------------- ---------------------------------------------------RGLSPG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TRPH--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GPRHRPTNH KSPG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------HHV H----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >Alligator:sinensis_Chinese:alligator_XM:025214710.1_NW:005841857.1_LOC102377700_Vertebrata_TRPN1 ------------------------------------------------------------ ----------------------------------MPETGSSLSPPASLASSCPVLQLAAR GEWIALEQTLKGMDKGDL---AAFQADPESGLTP----------LMVAVRENRLAI-VER LLELGVNPSEQTKNGRNALHVAAAHSKEE----------------IIRLLLARKADPN-- --------------------LPGGPKEQLPLHYAALRPLGAV------------------ -----------GVVQTLLRASHKDARLNPDTDSCLP-LSLAVEAGNPGVCKELLSA---- ------------HAEAQLRAQ----------------------------EKT-------- -YGNTALHVSCRKKDVEMAKILVEYGAGVDCPNEEGQTPLHLAAWEGDEALVKFFHHCKA KP--NITDKMDRSPLHLAAEQGHTHIVELL-----------------------------V EKFHSN------------------------------VLA--------------------- RAKDGS------------------------------------------------------ ---TLLHVASEHGHLDTALALLK-------KGVPLHMPNKKGVVCLHAAAKMGHAAVVKV LLQK-------------------------------------------------------- -GADVNARTRENYTALHVAAQHCRLLVVQTLLGFGAQVQPKGGQAGETPLHIAA------ ---------------------RIREGEKVAEMLLN-SG----------------ADVNVE QENGET----AMHIAAR------------------------------------HGNRRMI AALIEEGGKLTWP-------------------------SKAGECPLHIA----VRHCHLP VVEEILNYLAKEKSHADAVACASMENEAGETPLHVAAAVKKDMVHLEEEETKIVAMLLEY KADISRTTRLSLETPL-HYCAQVGNADVLLEMLKHISTHQMQQAINKQAKNGWSPLLVAA EQGHTAIARILLQTHARV-----DVFDEQ---------GKAALHLAAENGHDQIADLLLW --YKAFVNAKTKLGLTPLHLSAQNGYNHLVKLLVETHLASIDAMTLSKRTPLHLAALNGQ LDVCASLLSLGADVNAADI-QGQTPLHLAAEN-----------------DHSEVVKFFLK HKPELV--------------------TSANVEGSTCAHIAASKGSIAVVKELLKFNKAGV TTARNKTNNST-------------PLHLAAA----------------------------- ------------------------------------------------------------ --------------------GGHCEVVKVLLQ------TGASAADEDGEG-LTAIHLA-A KNG------HINVLEALRGSISFRITSTKTGFTALHVAAHYGQLGFVQEMLTGVSATTCS KLPQSKPEGEPVKEHTSESGFTPLHLAAHSGH-------------------ESLVRLLLN LPGVQVD-------------SQTSLQGSSPLHLAAQRGHTAVVGLLLSKSTSQLHLQDQQ G--------------------------------------------------------RTC LHLAAASGHVEMVRALLGQGAEINVTDK-------------------------------- ---QGWGPLHFAAKSGYLASVQLLVESG----------AAPTLESK--EGKTAVQYAAAE HHQDVMSFPLRKSNNTLKLLEDRKFIFDLMVCGKLNNHKVTEELVLHSSAP--------- -----LDTAVKLSWAFNLAALKE-KERA------------------KDLLAAAKYMESMA AEL---LTLAC-GG-------------------------------------KSASYLLRT VDHRG--------N-------------------------TMLDTLIE-----CEQKDVIA HPAVQNYLTEVWYGSVR------------------------------------------- -------WPPWKITLLFFSFLACP-----------PVWLFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------S--------------------------------------- ----LPLKHRFDTIPIVKFM-------SH-------------LASHIFLVVLFVLTVAYP ---PISPIGEE---------------------------------------RVVPH----- ------------------------------------------------------------ --------------------------------WN-------------------EWML-LA WLLGTFVTEITHPGE--------------------------------------------- -----------------------------RAGLAW------IRVFVLGFSAIASLCHLLA LVF----------------TGTDRLHCLFARNNFL------------------------- ---GAAMTLSFVQFLEFL-TFHHLFGPWAVIIRNLM-KDLTRFAVILGLFHIAFTMQLSS VYQPVYPESKAD---------------------------GNAT----GSTPTQD--PLDI TVTLFFSLFGLVDPESL-------PSPNRT------------------------------ --------------------------------------------------------PPFT FIIIRSVFGVYLIVTLIVLINLLIAMMSDTYQRIQAQSDT------------EW------ ---KFGRAVLIRDMTQK----SGTPSPF----------NLFTH----------------- -----------------------------------------------------LLYYV-- ------------------------------------KKLCKRRGKLCFTERRDLVNEEED LDAA---------------------------------------SNTRSIG-M-------- ------------------------------------------------------------ ----------------LAHASVRWTRVAAKRAAQVSPEGN-------------------- ----------------------------CIHNPLSAGPLHIKEAV--------------- ------------------------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WHS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VA-------IHYFSLKGRP D-------GSLLER------------------------------ELSMHQDLC------- -----------------KS----------------------------------------- ------------------------------------------------------------ ----- >Latimeria:chalumnae_Coelacanth_XM:014497951.1_NW:005821726.1_LOC102365890_Vertebrata_TRPN1 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MLVCIF---------- -----------LQDNRTVLHVAAAHSKDE----------------IVRNLLSRRADPN-- --------------------LPGGPKHQTPLHYAAARPNGAL------------------ -----------GVIQTLLKASHKDARLAQD------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KSGAVCLHAAAKRGHAAVVKA LLLK-------------------------------------------------------- -GAHVDAKTKDSYTALHIAVQYCKPLVVQTLLGFGAQVQLKGGKAQETPLHIAA------ ---------------------RVKEGEKVAEMLLK-SG----------------VDVNAE QENGET----AMHMAAR------------------------------------HGSLKMM QALIEEGGDLMWQ-------------------------SKAEENPLHIA----VRHCHLH VVEDVLCYLDTEKSHTEAVMCVNQENVEGETPLHLAAEIRKDMVHFEGEETRIIKLLMEF EADTTAVTKLTTETPL-HYCARVGNISVLLEILKHISSNRMQQAINKQAKNGWSPLLVSA ERGHTEIVKTLLQNHARV-----DVFDEH---------GKAALHLAAENGYDQIADILLW --HKAFVNAKTKLGLTPLHLGAQNGFNRLVKLLVETHLASIDALSLTKRTPLHLAALNGQ LDVCNSLLKMKADVNATDI----------------------------------------- ------------------------------------------------------------ ------TNDSS-------------PLHLAAA----------------------------- ------------------------------------------------------------ --------------------GGYAEVVKVLLE------AGASASDENAEG-MTPIHLA-A KNG------HINVLEALKGSVSFKLTSTRTGFSALHVAAQFGQLDFAREILTKVSATVCS EAPKSTVEGQQLKEQTSESGYTPLHLSAQYGH-------------------ESLVRLLLN HAGVQAD-------------TQTSLQGSSPLHLAAQNGHTAVVGLLLSKSTSQLHLKNKR G--------------------------------------------------------RTC LHLAAANGHIEMVRVLLGQGAEINVTDK-------------------------------- ---NGWTPLHFAAKSGYLETVRFLMESG----------ASPKLECK--EGKMAIQYTAAE NHQEVVSFLLKKNNTTLKLTEDRRFIFDLMVCGKQNSNRIIEEFVLHSPAP--------- -----LDTAVKLSRAFSLTALKE-KERS------------------MDLVNAARYCESMA NEL---LTVAS-GS-------------------------------------KSAGYLLRA MDHRG--------T-------------------------TMLDSLIE-----CEQKNVVA HPAVQKYLTEVWYGNLK------------------------------------------- -------WAPWKIALLFFSFLVCP-----------PVWLVF------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------S--------------------------------------- ----LPLKHRFNKIPIMKFM-------SY-------------LVSHIFLLVLFIITIVYP ---PLSPIYKG---------------------------------------RMIPY----- ------------------------------------------------------------ --------------------------------WN-------------------EWLL-LV WLSGMLVSELTHPGE--------------------------------------------- -----------------------------RAGLAW------IRVFVLGFSAVAFFCHLLA FAF----------------DDTDRLHCLFARNIFL------------------------- ---SVAMTLCFVQFLEFL-TFHHLFGPWAIIIRDLM-KDLTRFTVILVLFHLAFTMHLSA VYQPVYPEPVID------------------------PSLGNGTGNAGMSSAIQD--PVDV TVILFFSLFGLVDPDSL-------PPLSRT------------------------------ --------------------------------------------------------PQFT FVIIRFVFGVYLVVTLIVLINLLIAMMSDTYQRIQAHSDT------------EW------ ---KFGRATLIRDMTRK----SGTPSPF----------NLFTN----------------- -----------------------------------------------------LFYYI-- ------------------------------------KMLCRHGGKLCSTNGRGLMHEEED LDRI---------------------------------------SDTRSID-L-------- ------------------------------------------------------------ ----------------LAHTSVGWIQTSAKRSTKVSPEGN--------------IT---- ------------------G--------GFCRGSRSSGPAHIDKVI--------------- ------------------------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WHR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VA-------LRYLALKGQV D-------VALFEK------------------------------DSAQHED-N------- -----------------ST----------------GSERFSIPVNTKFLNG--------- ---------------------------VS------------------------------- ----- >Nanorana:parkeri_High:Himalaya:frog_XM:018560910.1_NW:017306756.1_LOC108790601_Vertebrata_TRPN1 ------------------------------------------------------------ ----------------------------------MSNAGT--GPGAHGEVGRRILQLAVR GEWITLEQTLKGIEKGDL---GNNETDPESGLTP----------FMIAVRENRLSV-VER FLELGVNLQERTQDCRTAVHVAAAYSKEE----------------IVRLLLAKKAEPN-- --------------------LPGGPKDQLPLHYTAQRPNGAI------------------ -----------SVIQTLLRASHKDARLVQDKDGCIP-LLVAVEGGNLGICKELLTS---- ------------HTEPQLRAK----------------------------SKK-------- -YGDSALHACCRKRYVDLAKLLVECGAPVDCQNEEGQTPLHIAAWEGDEVMVKFLHQCKA NS--NIMDKLERSALHIAAERGNTAIVENL-----------------------------T DKFHSN------------------------------VLA--------------------- RTKDGD------------------------------------------------------ ---TLMHIASQCGHPETALAFLK-------KGVLLHMPNKSGAVCLHAAARRGHAAVVKA LLQK-------------------------------------------------------- -GAHVDAWTKEDYTALHIATEACKPHVVQTLLGFGAQVQPRGGKVQETPLHIAA------ ---------------------RIKDGEKVAEILLK-SG----------------ADVNME QANGET----AMHVAAQ------------------------------------YGNLKMI SALIEEGGEVTWQ-------------------------SKAQENALHTA----VRHCHLP IVELILGYLSNEKSKAEALCCVNQPNQEGETPLHLAAALAKDSIHFEEEDVKIVRLLLEH DADISCSTTQAGETPL-HYCARTGNKEVLSEMITHIGAGRLQHTMNKQAKNGWSPLLVAA EKGHTGVVKILLQNHARA-----DVFDEH---------GKAALHLACENGHDKMADILLW --HKAFVNAKTKLGLTPLHLCAENGFNHLVKLLVENYLATIDAMSLTKRTPLHLAARNGQ LDVCNSLLNMKADVNATDI-HGQTALHLAAEN-----------------DHSEVVKLFLK HRPEQV--------------------TSANMDGSTCAHIAAAKGSVAVIKELLKFNSSGV TTARNKTSDST-------------PLHLAAA----------------------------- ------------------------------------------------------------ --------------------GGHTGIVKVLLE------TGASASDEDKEG-MSAIHLA-A KNG------HINVLEALKGSVSFRITSTKTGFTALHIAAHYGQLNFVREILTKVPATIQS EPPKSAVDMLHLKEHSGESGYTPLHMASQSGH-------------------ESLVRLLLN YPGIQVD-------------AATSRQVTIXYEVTLRXXXXXVVGLLLSKSTSQLNMIDSR G--------------------------------------------------------RTC LHLAAANGHNEMLRALIGQGADINVTDK-------------------------------- ---NGWCPLHCAAKSGFLDTVRFLVECG----------ANPTSECN--DGKTAIQYAAAD NHQEVLSFLLRRSHNTLKLTEDKKFVFDLMVCGKLNNNRIIEEYILNSNAP--------- -----LDTAVKLSRAFSVTALKE-KERA------------------VELLNAAKYSETMA TEL---LTIAS-GS-------------------------------------KNAGYILRS VDHRE--------T-------------------------TILDCLIE-----CEQKNVVA HPAVQKYLTEVWYGNLD------------------------------------------- -------WATWKLVLLFFTFLACP-----------PVWLIF------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------S--------------------------------------- ----LPLKHRFNKIPIMKFM-------SY-------------LASHIFLIVVFILTIVYP ---PLSPIHEG---------------------------------------HMVPY----- ------------------------------------------------------------ --------------------------------WN-------------------EWLL-LA WLSGLLVSELTHQQE--------------------------------------------- -----------------------------RAGLAW------IRVFVLGFSAVAFFCHLLA FLF----------------KDTDRLHCLFARNIFL------------------------- ---GVAMTLTFVQFLEFL-TFHHLFGPWAIIIRDLI-KDLTRFAVILALFHVAFTMQLSA VYQPVYPEPSAI------------------------YSYNGTTKLR-NESNIQD--PIDI TVLLFFSLFGLVEPGSL-------PSLSRT------------------------------ --------------------------------------------------------PQFT FVIVRFVFGVYLVVTLIVLINLLIAMMSDTYQRIQAQSDT------------EW------ ---KFGRATLIRDMTRK----PGTPSPF----------NLFTN----------------- -----------------------------------------------------LFYYI-- ------------------------------------KLLCKHKGKMCSANARTLMNE-ED VEVF---------------------------------------PDTHSID-L-------- ------------------------------------------------------------ ----------------LAHSSFGWVRTTAKRTMQVSPEGS-------------------- ----------------------------IYRDHQFAGPVRVDEII--------------- ------------------------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WHA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VV-------VRYLSLKGQT D-------RVTPDR------------------------------SVPQTTDVC------- -----------------SK----------------PLSHLA--PNKKLHNG--------- ---------------------------WIEFSSQ-------------------------- ----- >Lepisosteus:oculatus_Spotted:gar_XM:006635845.2_LG11_LOC102695672_Vertebrata_TRPN1 ------------------------------------------------------------ ----------------------------------MSETCS-VSSGSVVNSGQRILLLALK GEWITLEQTLKGFDKGDP---EISQTDEEFGFSP----------LMIAIKENRLSI-VDR LLELGVNLSDRTKDGRTALHVAAAHSKDE----------------IVK-LLVKKTDPN-- --------------------VPGGPKDQLPLHYAASRPTGAQ------------------ -----------NVIQTLLRFSSKDARMVQDKDGCIP-VFLAVEAGNIGVVKELLGA---- ------------TPEPQLRAQ----------------------------RKG-------- -NGDAALHICCRRKDIEMAKFLVEFGASVDFQNDEGQTPLHVAAWEGDELMLKYFYQCKA NP--NIVDKMDRSPLHIAAERGHTNAVEVL-----------------------------T EKFRSD------------------------------VLA--------------------- RTKDGS------------------------------------------------------ ---TLMHIASQCGHPETALAFLK-------KGVPLHMPNKAGAVCLHAAAKSGHSAVVKA LLQK-------------------------------------------------------- -GAHVDATTKDNYTALHVAVQSCKPLVVQMLLGFGARVQLKGGKAQETPLHIAA------ ---------------------RVKEGEKVAEMLLK-SG----------------ADVNAE QENGET----AMHIAAR------------------------------------HGNLKMM QALIEEGGDVTSK-------------------------SKAGESPLHIG----VRHCHAH IVQEILSYLANERSPKEATVCVRQENQEGETPLHLSAELKKEMIHFEGEDIAIVRILMEC DADVSAATKVSGETPL-HYCARVGNADVLLEILKSLKSSQLQQAVNKHAKNGWSPLLLAA EQGHKQIVKILLQNHARV-----DVFDEH---------GNAALHLVSGKGHEEIADILLS --HKAFVNAKTKLGMTPLHLGAQNGYNRLVRMLVETHMAGIDALSLNKQTPLHLAALNGQ LEVCSSLLNMRADVNATDI-HGQTPLHLAAEN-----------------DHSEVVKLFLN HRPELA--------------------TLANVEGATCAHIAASKGSVAVIKELLKFNKGGM TSAHNKTNGSS-------------PVHLAAA----------------------------- ------------------------------------------------------------ --------------------GGHTEVVKVLLE------AGASAAEENAEG-MTAIHLA-A KNG------HTHVLEALKGSISLKIYSTKTGLTALHVAACFGQTDFVREILTKVPATMRS EPPQSSTEGQPGREPLAESGLTALHLAAQSGH-------------------EGLVRLLLN CPGVQAD-------------AETNLQGSTPLHLAAQNGHTEVVGLLLSKATSHLHLKDKR G--------------------------------------------------------RTC LHLAAANGHVNMVRVLLGQGAEINDIDK-------------------------------- ---SGWTPLHFAAKSGFLGMVRFLVESG----------ASARMECK--EGRTPIQYAAEE NHQDTVSFLLRQDNNTFKLVEDRKFIFDLMVCGKLNNNAVIEEFVLHSPAP--------- -----LDAAVKLSRAFGLTALKE-KERS------------------MDLLNAAKYCEGMA TEL---LTVAS-GG-------------------------------------KSAGYILRA LDHRG--------T-------------------------TMLDCLIE-----SQQKDVVA HPAVQKYLTEVWYGSLK------------------------------------------- -------WAPWKIVLLFFCLLSCP-----------LLWLAF------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------S--------------------------------------- ----LPLKHKFNKIPIMKFM-------SH-------------LVSHIFLLLLFILTIVYP ---PVSPIYLG---------------------------------------NLLPE----- ------------------------------------------------------------ --------------------------------WN-------------------EWLL-LA WLSGMLVSELTHPGE--------------------------------------------- -----------------------------RAGLAW------IRVLVLGFSAVAFFCHLLA FAF----------------QSPDDLHCLFARNIFL------------------------- ---AVSMTLSFVQFLEFL-TFHHLFGPWAIIIRDLI-KDLARFAVILVLFHTAFTMNLSA VYQPVYPE---E------------------------LSFGNTTGDH-NSTEIQT--PLEI SIKLFFALFGLIDPDSM-------PSLNRS------------------------------ --------------------------------------------------------PAFT GVITHFVFGIYLVVTVIVLVNLLIAMMSDTYQRIQAQSDT------------EW------ ---KFGRAVLIRDMNRK----SGTPSPF----------NLFTN----------------- -----------------------------------------------------LFFYV-- ------------------------------------KMLCKHGGKVCSSEGRDLMTEEED LDAV---------------------------------------SDTHSLD-L-------- ------------------------------------------------------------ ----------------LARTSVGWMRTNRR--SQISPEGG-------------------- ----------------------------FVRHSRQSGLLHIDEVT--------------- ------------------------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WHT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VA-------LRYLVLRGKT D-------ETLLEK------------------------------NQCPYEEPI------- -----------------MV-------------------HFKHPSNANMPDH--------- ---------------------------IS------------------------------- ----- >Callorhinchus:milii_Elephant:fish_XP:007884996.1_NW:006890060.1_LOC103174373_Vertebrata_TRPN1_TRPN1 ------------------------------------------------------------ ----------------------------------MSETGS-IGSGSTVASGSRIVLLATR GEWGALEQALKGIDRGDR---DISLSDEDSGLTP----------IMIAVRDNKLAI-VER LLELGATLSDRLKDGRTALHLAAAHSKDE----------------IVRLLLAKKADPN-- --------------------LTGGSKDQLSLHCAANRTSSSL------------------ -----------SIVQMLLRASHKDARLVQDKDGCLP-LFLAIEIGNVAVCKELLSV---- ------------SADIQLRTQ----------------------------RKD-------- -TGDTALHVSSRKRDAELAKLMVEYGADVDFQNEEGQTALHVAAWEGDEFLLRFFYQCKA NP--NIPDKLDRSPLHIAAERGHTNVVEVL-----------------------------T EKFKSN------------------------------VLA--------------------- RTKDGS------------------------------------------------------ ---TLMHIASQCGHPDTALAFLK-------KGVPLHMPNKSGAVCLHAAARRGHTAVVKA LLQK-------------------------------------------------------- -GAHVDAKTKDRYTALHIAVQYCKPMVVQTLLGFGAQVQLKGGKAQETPLHIAA------ ---------------------RVKEGEKVAEMLLK-SG----------------ADVNTD QENGET----AMHIVAR------------------------------------HGNLRML QALLEEGGDLTCQ-------------------------SKAGENPLHIA----VRYCHVN LAEEILNYLASKRSHSDAVACVNQENKEGETTLHLAAQIRKDMTHSDQEDTQIVRILMEF GADITAATNLIHETPL-HYCARVGNADVLLEILKHISSNRIQRVINKQAKNGCSPLLVAA ERGHTEIVKILLLHHSRV-----DVFDEH---------GKAGLHLAAENGHDHISDILLW --HKAFVNAKTKLGLTPLHLGAQKGYNRLVKLLVDTHGASIDALSLSKQTPLHLAAVNGQ LNVCSSLLNMKANVNATDI-HGQTPLHLATEN-----------------DHSEVVKLFLK HKPELV--------------------TSANVEGSTCAHIAASKGSVAAIKELLKFSRASV TSARNKTNTST-------------ALHLAAT----------------------------- ------------------------------------------------------------ --------------------GGHAEVVKVLLE------AGASATDENAEG-MNAIHLA-A KNG------HINVLEALKGTISFKLTSAKTGLTALHVAALFGQMDFVREILTKVPATMKS ETPKTTNEAHLL----SESGYTPLHLAAQSGH-------------------ENLVRLLLN YPGVQVD-------------AQTNLQGATPLHLASQSGHTPVVGLLLSKCTSLLHLKDKR G--------------------------------------------------------RTC LHLAAASGHIEMVRALLGQGAEINGTDK-------------------------------- ---NGWCPLHFAAKSGCLDTVRFLVEGG----------ASAKLECK--EGRTPIQYAAAE HHQEVVSFLLRRNNITLKLTEDRKFIFDLMVCGKLNGNRVIEEFVLHSPAP--------- -----LDTAVKLSRAFDVAALRE-KDRS------------------MELLNAAKYCEGMA TEL---LTVAS-GS-------------------------------------KSAGYLLRA VDHRT--------T-------------------------SLLDALIE-----CEQKEVVA HPVVQKYLTDVWYGSLH------------------------------------------- -------WAHWKVVLLFFSFLVCP-----------PIWLVF------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------S--------------------------------------- ----LPLGHRFTKIPIVKFM-------SH-------------LVSHVFLLLLFVVTVVYP ---PLSPVHQG---------------------------------------RALPR----- ------------------------------------------------------------ --------------------------------WN-------------------EWLL-LA WLSGMLVSELTHPGE--------------------------------------------- -----------------------------RAGLAW------IRVFILGLSAVAVFCHLLT FAL----------------RGHDRLHCFFARNIFL------------------------- ---ATAMTLCFIQFLEFL-TFHHLFGPWAIIIRDLM-KDMARFVVILALFHVAFTMQLTA VYQPVYPEPQPD------------------------PSAGNRTESEVGVHSIRS--PLDI TVLLFFALFGMVDPDSL-------PPLDRA------------------------------ --------------------------------------------------------PAFS HVIVRVVFGMYLVVSLIVLINLLIAMMSDTYQRIQAQSDT------------EW------ ---KFGRATLIRDMVRK----SSTPSPF----------NLCTN----------------- -----------------------------------------------------LFYYT-- ------------------------------------KLLCKHKGKLCSTEGRDLMNEDDG LDAI---------------------------------------SDTHSID-M-------- ------------------------------------------------------------ ----------------LAHTSVGWIRNTSK-TTQVSPEGG-------------------- ----------------------------FLHNLRHNGSTKIEDVI--------------- ------------------------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------WHS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VA-------LRYLTMKGRT D-------VVL-ER------------------------------HSSQYDEAN------- -----------------SA----------------G--HFAVLVRSKLLNG--------- ---------------------------LSM------------------------------ ----- >Hydra:vulgaris_swiftwater:hydra_XP:002168781.2_Cnidaria_TRPVL ------------------------------------------------------------ ----------------------------------MNSENIFYKRVVNNALLYR------- -----------------------NGPS--------------------------------- ----------------------P------------------------------------- ------------------------------------------------------------ ------------ILD--------------------------------------------- --------------EELLSS-----------------------------SK--------- -----------IKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NNAPLGVSEYFASEENE-------------AQ--------------TKNAGSEV LIIY-------------------------------------------------------- ---FAKLGRSYAENIP-VDLNYVK-------------------TLIQSGADV-------- ---------------------------NFTDNF--------------------------- ---GQT----VLHEAAL------------------------------------RWPIEVA QFLFNHSANLNK------------------------------------------------ ------------------------------------------------------------ -------------------ADKYGRT----------------------------PLHVAA SVDYPEMVKWLID----------------------------------------------- ------------------------------------------------------------ ---------NGADVRAITLNENQTPLHYASK-----------------CNSVNSLVTLLE M--------------------------GAGLD-----D-TD------------------- ------FKERT-------------PLQIAAE----------------------------- ------------------------------------------------------------ --------------------TGREESCRLLLQ------YGAPAGVYDDTG-MSCLTHLIE KLP------DVA----------------GEALDQF-QKIN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KGTR------------------------------------------------ ----------------------------------------TTF----------------- -------------------------------------------FYLSYLEK--------- --------------------------------------------KKWKMNRKLLKKS--- ------------------------------------------------------------ --------------------------------HRMVFVREPLEVIVK-----YKDLTLIM HPVIQRLIQKKT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QLFGRR------YFI-------FM-------------FLINLLFTVLWTA----- ---------------------------------------LTVTLPYYNF-ANSPLTDSNQ SAT----TNSNPTMTSLVITNSTSESMTTNFIGSTSITLTDFIRSSSDSITSINYISTNT SSADFIILSSTTSTNSNSFTNTTSTNSTNSSELNG-ASVFQVEFYTPYNKNSWRFVLEII GLLLAVYFFIQTRIQFMIVKRNFKDFKVSRLQELRRDMNFCHPRWPQEQRVINEEEVNIK ----SE-------------------------TMGS------FYDVWFILDVLCYVGLVFL SIT-RIMLISLKEVD------NKYLITLKAHYYAF------------------------- ---PVILFIIWLRFMSAF-RPFITLGPFIAMFGCIA-EETVKFAFLFMEFLIPYACAIWI IFGGPH-----------------------------------EVFQGS-QYPY------AY FDDVMFELLRMTVTDNFAYAPLYTY---------------------------NAPTSADS -----------------------------------------------------GTVGSTE KIVAQIITGTFFALMSITLMNLYIGLLSNTFSRVFSNATA------------TA------ ---YMLQAEALVIAEKK------MRKKDRNTVQKIIAKKCSPEVVY-------------- ----EQVDEEDANQVLAMLEKIGRQ--------LDF-------IQKFQVD-------L-- ------------------------------------------------------KTKTDY LVDE---------------------------------------V---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Nematostella:vectensis_starlet:sea:anemone_XP:032222722.1_Cnidaria_TRPV5 ------------------------------------------------------------ ----------------------------------MMI----PNGKTANNKVAPV------ ---------------------ILNE-----GNIS-------------------------- -----AGVEPGLTNHA------D------------------------------------- ------------------------------------------------------------ ------------ALE--------------------------------------------- ---------------EEIKR-----------------------------SK--------- -----------GKIRK----------------------PRGINSIGSGTKVKVGFTRWKK A-----------AL----------DGIHKS----------------------------KN EGQK-------------------------------RTFK--------------------- --DKL------------------------------------------------------- ------KVSGDKISHRMNAAQLSDLEDLV---DGDGANKHKGNGIANGANGTSISSSSRA LLYY-------------------------------------------------------- ---FAKLSANANTNEV-IDLEFVE-------------------TLIKTGASV-------- ---------------------------SVTDRH--------------------------- ---GQT----VMHETAR------------------------------------QWEVAVA KFLIKRGASINQ------------------------------------------------ ------------------------------------------------------------ -------------------ADRFGRT----------------------------PLHVAA AVDYPDMVRFLVE----------------------------------------------- ------------------------------------------------------------ ---------NGADVHARTSGELQTPIHYAAR-----------------NDAATSLKMLLR C--------------------------GANMD-----D-RD------------------- ------YKERT-------------PLQVAAE----------------------------- ------------------------------------------------------------ --------------------LDRSETAKLLVK------QGADAGVMDDSG-MTALVMMIS KMP------VVA----------------KEALNQF-YSYD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RANR------------------------------------------------ ----------------------------------------KQY----------------- -------------------------------------------FYLNYLEP--------- --------------------------------------------VIPKCINIGW------ ------------------------------------------------------------ -------------------------------------PQTALEVVVL-----HKQFDLIM HPVYQRLLKVKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QSFGKR------GAW-------FQ-------------AISSLIYVILWTV----- ---------------------------------------IGITK---------------- ------------------------------------------------------------ -------------------------------------ADKPSEYYQPISEKWWRIGLYVF AVLMTFNEIRREISDILFSKKEHRLWMKWRETELQRDLKYCHPRWPGERIYLMQEIDFLH -------QQEPS----------------------Y------FNDAWNVFDWLTYCMVMAS LVT-HGVSVLIDHM-----------MVHNAHINIM------------------------- ---SATLICIWIRLLKTF-RAFTALGPFVVMLGHLI-YDILKFFFLFVVFYIPYAASFWM VFSSHN-------------------------------------ISG-----Y------ST IADLLFSMFRMTVVDDYNYDELS------------------------------------- ---------------------------------------------------------KAE PIMSKILCGTYLAFSAIICLNLFIALMSDTFQRVYDNVKA------------NA------ ---AMQQANTILSLENN------LSVTKKKKFANFIHTRCSPD----------------- ----ELYYDD------------------------DVLDDDEGDLKRMTHQ-------I-- ------------------------------------------------------KEELEE M----------------------------------------------------------- -----------------------------------------------HSKM-DA-QGSKK ------RAGVDGVKSDVTRDELDALRGDLGRVEQQQRAM---------------TA---- ----------------------------QFHTQIGELKEMLR------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVMVKLNKP--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R KK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RHV Q--------TSFEE-----------------PGV------------GEH----------- ------------------------------------------------------------ ----------------------------G-HLQTL------------------------- ----- >Orbicella:faveolata_XP:020619676.1_Cnidaria_TRPVL ------------------------------------------------------------ --------------------------------------------MSRNGRVHP------- ---------------------------------A-------------------------- -----TSVGSSDYEHRR-----D------------------------------------- ------------------------------------------------------------ ------------FMEM-------------------------------------------- ------------NRMNHVTK-----------------------------SR--------- -----------KR-------------------------AESVENWQKVSKEVVVVSRWRD Y-----------MRSMRGSQKETSSGLNR------------------------------S GMYS-------------------------------RVIS--------------------- HVETEMT----------------------------------------------------- --CVLDSDVEDLGNERLAMYDTN-------------AYMKPMPAVKQGEQIHPAIAASRT LIIY-------------------------------------------------------- ---FAQLAKASLEREQELDFDFIE-------------------GLFGEGADV-------- ---------------------------NFTDRY--------------------------- ---GQT----VLHEVAR------------------------------------IWHVDVA RFILENGGDVNK------------------------------------------------ ------------------------------------------------------------ -------------------RDEYGRT----------------------------PLHVAA AVDYPEMVEFLVS----------------------------------------------- ------------------------------------------------------------ ---------SKADLHACTTGENQTPTHYAAK-----------------NDAARALKVLLK L--------------------------GGRME-----D-RD------------------- ------YKKRT-------------PLQVAAE----------------------------- ------------------------------------------------------------ --------------------LDRSETAKYLID------QGAPAGVQDNTG-SSVMSFMIS KMP------PVA----------------KEALDQF-HSTD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGNR------------------------------------------------ ----------------------------------------RQY----------------- -------------------------------------------FYLNHLEP--------- --------------------------------------------VLPNEEGAYV------ ------------------------------------------------------------ -----------------------------------SCARSPLYCVVH-----YKQMELIM HPVFKRLIEVKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DQFGWR------GTV-------KM-------------IFIHALFVLLWTA----- ---------------------------------------LGVTLH--------------- ------------------------------------------------------------ -------------------------------------LGEDSDYYNPPDVYWWRIVLETL ACTMTLYFICLEFLEIGASKKFHQKWKKWRISQLDRDLHYCHPRWPEERKYLEMERNEII ---DSG--------------------------ISY------FNDSWNYFDWVTYAWILGI IVT-RIFAVVLKND-----------SARSLHPKVF------------------------- ---AIALIFIWLRLMKVF-RGFVTLGPFIVMIGHII-DDTLKFGFLYFEIYVPYVCAFWI IFGGKK------NAE---I-----------------MEKAGQDSKG-----W------AD FNDLMYSVWQLTVVGNYPWDSLL------------------------------------- ---------------------------------------------------------VVD RLMAQILCGTYLAVSAIVMLNLFIALMSDTFQRVYDNAKA------------NA------ ---AMQRASTILNMEEN------MGDKSREMHRRFIHQRLAPE----------------- ----EMYYDD------------------------DSTQPGSGTLERMTHQ-------I-- ------------------------------------------------------KDVVDE VYEM---------------------------------------LQA-------------- -----------------------------------------------KSNG-TS-KADRN -----------------LGREIERLRSDLAVVSNRHEET---------------VK---- ----------------------------DMRNEVAEMKALLIRVLQQN----SVPSL--- ---------------------------------------------------PSMR--SLQ -D-Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------HHSPEHLNTNEA--------- -----RMP---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TKRSAS---------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SRSRR KKH------------------------------------------------RRQVSH--- ------------------------------------------------------------ ------------------------------------------------------------ PSDDEVD--------HG------------------------TYQGLP------LGDDTKG E--------SN-EL-----------------PSVRV--LVSRVSSSRQHKED-------- ------------------------------------------------------------ ----------------------------Q-DRS--------------------------- ----- >Dendronephthya:gigantea_XP:028405944.1_Cnidaria_TRPVL ------------------------------------------------------------ ----------------------------------MAD----------------------- ------------------------------------------------------------ ----------------------D------------------------------------- ------------------------------------------------------------ ------------PGE--------------------------------------------- --------------DEVVLL-----------------------------DP--------- -----------RR------------------------------------------NQYME K-----------KKLFEEMLLKEIPGTSR------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ANEPMHAVLEGEVAESEMT-----------------------EGKE--AQNVRNRA LLHY-------------------------------------------------------- ---LASLANSNSTKDT-FDFDFVE-------------------SLFKNGADV-------- ---------------------------NSADKT--------------------------- ---GQT----VFHEVAR------------------------------------SWNVDVA KFLLNHGANVNQ------------------------------------------------ ------------------------------------------------------------ -------------------QDQYGRS----------------------------PLHVAA AVDYAEMVDFLLE----------------------------------------------- ------------------------------------------------------------ ---------NGADIDIKTSGEGQTPIHFAAK-----------------NDAINSLQMLLG Y--------------------------GADID-----G-RD------------------- ------SKNRT-------------PLQVAAE----------------------------- ------------------------------------------------------------ --------------------MNRSKAAKLLIA------KGAPAGVCDNLG-NSALSLLIE KIP------EVA----------------LDAMDQF-HSVD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TVNR------------------------------------------------ ----------------------------------------KEF----------------- -------------------------------------------YFLNYLES--------- --------------------------------------------TKLKE----------- ------------------------------------------------------------ ---------------------------------KKTPARTPLEIAVQ-----NERFDIIM HPVMQRLIGVKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QMYGKW------AAI-------LD-------------LVLNLLYTILWTI----- ---------------------------------------LAVTL---------------- ------------------------------------------------------------ -------------------------------------PRHGKDLYVPLVSNIWRIVIVGI LILLTLNEIRKQILNTIRTQRDHKGWKEWRASELERDIEYCHPRWPQEAQYVNAEIKAVR NL-----------------------------SLMS------GSDHWIYFDWVALVLIFAT IAS-HLVFFHYSTD-----------LSKEVHHYIT------------------------- ---MPLLLVLWLRMFKYA-RPFEGAGPFIVIFGSVV-GDIVKWGFFNIIICIPFACAFWM TFGNVSTKP----------------------------------VEG-----Y------NK VGPLLYNIFSMMVGNGHRFEYLE------------------------------------- ---------------------------------------------------------RTK PFMARLLTASFIAVGAIVTLNLLIALLTNTFERLYENAIA------------NA------ ---VMQRARTLLLLEKS------LWRRKEANYYEFIRKHGSPEVISKNIGRLLSLDRDEA T--IERVRDDVSGIVAILAEKFGKKSRKGKKSDLDFVRMDVSKMQRFQQEIVIDVKNI-- ------------------------------------------------------KLSLEE IKAV---------------------------------------VSQVANN-S-------- -------------------------------SSKKS---ND--VTVDETKE-SS-EEDDN -----------STSNDETKNDNSSSSSDDDEVQTEKKAK---------------TKP--- ----P----------------------FPKKPEIASKKPIIKPRVDRP-KKEQVEKLRKK FEQTTENVDKERRHDRKDKPAKETYEENDDHDERYDMMQGENNTGRRKIRHPSWRLVGLC -Q-P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TNLPTNTNFSQPCSHHVGQSQ YQERSDIP-M-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------HSKKNES-----------------------------------RKVTYFVDDH- -----------------EFQMRPDRD-----KNN---------------------LKCLQ FHPEK-------STEVYFGQNSSENAQPHNNNQFSSDRIYSTPRRKRVSFNEFDMARTSE KQHSADSS------------------------------------------SRRRMKASSF NEFD-M--------------------------------TKNNEKQHFEGLSTRRNKMT-- -------SFNEFDLMN-------------------------NVQKQQ-------TGEYCQ PCYCETDDGVRTCHHHD------------------------VQDTISTNNERALWKNTHY E--------DRLNQ-----------------PQQ-------TFSSTFLHFDDDLGYCSHS IQPN--FSRNRLS--G-R------------------RRPVQQAR-NENI----------- ----------GPR--------------CR-HSDSRIVEIPYVERIYHPVPAINSDFSSSE GN--- >Capitella:teleta_ELU06894.1_Annelida_TRPVL ------------------------------------------------------------ ----------------------------------MSE----KNYKSKKGKGWKV------ ---------------------FPEDPVDGYENEA-------------------------- -----YEMEDDSKSNNRSLDAKD------------------------------------- ------------------------------------------------------------ ------------RLK--------------------------------------------- ---------------AAFRF-----------------------------A---------- --------------------------------------SNQNNAINLIANIKAGTTRWRK Y-----------ATTRRQISDTGSDGFDRR----------------------------KT GGIG-------------------------------LDYE--------------------- VGSTS------------------------------------------------------- ------SDSPDGAPDRLDKTQKE-----------------------------MVIACNRN LIEY-------------------------------------------------------- ---FARLGQSKDESEC-INLEFVE-------------------SLLNSGARI-------- ---------------------------DCTDKY--------------------------- ---GQT----IFHEVAR------------------------------------AWHTDVA QFLLDHKCDVNV------------------------------------------------ ------------------------------------------------------------ -------------------SDIFGRT----------------------------PLHVAA AVDYPEMVTFLVQ----------------------------------------------- ------------------------------------------------------------ ---------NGADIERVTKGEKQTPVHFAAR-----------------NDACQSLKALVK C--------------------------KALYK-----EVRD------------------- ------YKGRT-------------PLHLAAE----------------------------- ------------------------------------------------------------ --------------------LDRSETARFLLEL----PDAAPAGVEDLSG-QAAIVWMIK KMP------PVA----------------KLALEQF-HTTD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RANR------------------------------------------------ ----------------------------------------KQY----------------- -------------------------------------------YYLNCLEP--------- --------------------------------------------QKPENMMEENQ----- ------------------------------------------------------------ --------------------------------KKNTFAESALAVVVA-----YHQYDLIL QSVFEALINLKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KRFGRL------GAF-------FN-------------TFMNLLFIVLWTI----- ---------------------------------------LGILV---------------- ------------------------------------------------------------ --------------------------------------PYDERYKYDLPEHWWRIVLFIL ALTFTGWQVKDELSEFFSSRKNHKRWCEWREAEITRDIDFAHPRWPEEEQFLRCEINELD -------KMTPQ----------------------Y------FNDFWNIFDWICYALLTTC VIT-HLVDIWAHTN-----------FVARLHIQIM------------------------- ---AVTIIVIWLRLMKNA-RAFSTLGPFIVMLGHMF-SDILKFFALYLEFYIPYACAFWM LFGGEKTPPEFQGTP---E-----------------AANNTIIVDG-----Y------KD ASSLLFSLFRLTLVDDYDYDGMK------------------------------------- ---------------------------------------------------------AVD PVMADILVGTWLALSAIVMLNLFIALMSDTFQRVYDNAKA------------NA------ ---VMQKAITILSIEEN------MGRKRRDKFLEHIHKNCAPM----------------- ----EDFYDD------------------------DTTEESGDDLKKVTIQ-------I-- ------------------------------------------------------KEQLDD LEEN---------------------------------------LREGRIN-M-------- -------------------------------GLHGD---SD-----DDDNL-DS-NSVEN NSNGSQRKKLRVVTAQRFDRETTVIRDELQTVRAQQEYM---------------SD---- ----------------------------KMKKDMSRIKTLLKRLLVQQMGSASVEGLAEE PGMT---------------------------------------------RSSSMR--GLE -Y-Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------APQDEMNRLSRPESAY----- ---RGRTPHT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GQRKTSSA---------------------------------YKRPTV----H- -----------------E-----------------------------------------G LH--R-------GTE-----------------------------------EDWEMSETRR KKELDD--------------------------------------------LRKELEEKAL AATE-------------------------------------------------------- -----------------------------------------------------------D PPPPQVD--------IL------------------------RLDSSPVITPPALDDPRPV E--------TTYDF-----------------PD-------------SQHLGD-------- ------------------------------------------------------------ ----------------------------G-HTSS-------------------------- ----- >Dimorphilus:gyrociliatus_CAD5123450.1_Annelida_TRPVL ------------------------------------------------------------ ----------------------------------MTETEDSKRKKSKNGRKKR------- ------------------------------SNAK-------------------------- -----LNVSESDENNKLS----D------------------------------------- ------------------------------------------------------------ ------------GLE--------------------------------------------- ---------------KTFTI-----------------------------SP--------- -----------KRKSL----------------------TSKANAIVAITNAKTGGNKWQH Y-----------TKTRRLVSLDG-DKVDRR----------------------------KT GGQG-------------------------------LVID--------------------- LQQDE------------------------------------------------------- ------NRSEDAVDGKMRTSEIK-----------------------------YRKGQNRL LIEH-------------------------------------------------------- ---FAQASKHPHQNDA-VDFDFIE-------------------KLLQNGADI-------- ---------------------------NCADKY--------------------------- ---GQT----VLHEVAR------------------------------------VWHIDVA KFLLENGADIDR------------------------------------------------ ------------------------------------------------------------ -------------------GDNYGRT----------------------------PLHISA AVDYTEMVNFLIM----------------------------------------------- ------------------------------------------------------------ ---------EGANKESLTKGELQTPTHFAAR-----------------TDSVNSLKALIN H--------------------------GCEYK-----QKRD------------------- ------YKGRT-------------PLHVAAE----------------------------- ------------------------------------------------------------ --------------------LDRSETARMLIEL----DDPAPAGVIDDSG-QSAVVLMIT KMP------PVA----------------KLALDQF-HTTD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RANR------------------------------------------------ ----------------------------------------RQF----------------- -------------------------------------------YHLNHLEP--------- --------------------------------------------KKAGDQLKGH------ ------------------------------------------------------------ -------------------------------------PQTALRVLVA-----FNQIDLIT HRSVERLLEIKW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RNFGKK------GGL-------WQ-------------IVKAVIFIGIWTA----- ---------------------------------------IGLSK---------------- ------------------------------------------------------------ --------------------------------------DHETRHEYNLKSEWWRIILWIL AVAMTLWQVIEEIKEYRSSRKAHLKWKNWREEEVRKDLQFCHPRWPEETAYLNSEIDRLN GINDSEVKTVPEETSSVKTFCYSFVA---LFRASY------FNDPWNIFDWICYVLLTVA SIT-HVVDVIDHTN-----------AISRWHIRIM------------------------- ---AIAIILIWIRILKIA-RAYS-VGPFVVMIFKML-TDIFKFVFVYLVFFCPYVFAFWM IFGASKRPEKNINEI---H-----------------LNRTKSSVSG-----M------KT FDMLIFTLFRITLVDDYDFDGMI------------------------------------- ---------------------------------------------------------GID KFMTFLLLGSWLALSAIIMLNLIIALMSDTFQRVYDNARA------------NA------ ---AMQKAITILNIEEG------LTKKKREKFREYIHNYCSPE----------------- ----ERFYDD------------------------DDIDDGKESLQKVTIQ-------I-- ------------------------------------------------------RQRLDS ILDY---------------------------------------L---------------- -----------------------------------------------NPEM-SS-YSVNQ ------------------------LTDKNQAVVVIQVLF---------------YK---- ----------------------------KIER---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Caenorhabditis_elegans_ced-11_P34641.1_TRPS ------------------------------------------------------------ ----------------------------------MDETDP-------------------- ------------------------------------------------------------ -------VPDMSLLPDTVPVVVSGDGSA-------------------------------- -------AGIQLCPA---------LILGSPQALPGA------------------------ ------------------------------------------------------------ ------------IKHIYSRL-----------------------------A-------AAA SEVDQ-----------G--------------------VPDLIISLISHGNSL-------- -----------STKYMSSVENGLKSFLIG------------------------------C GTW---------------------------------LIS--------------------- SGEVND------------------------------------------------------ ----PMSRVASGALKNVLPQ-----------------LEHQAEVLHILVNS-------DD MIAS-------------------------------------------------------- -DTTNSKSVVDTSLNTLLLICRKEP-----------NDSYETVASSIAKLRA-------- ---------------------------ATAVKL--------------------------- ---AHPPP--ALLIGVPSEPMS----------PSTY--GNSAAI---LLSPS-NDKRPFP VAIFAGASKE-------------------------------------------------- SLIELLFFVEHG------------------------------------------------ -------------IP---------------------------------------VIILQD SCELCAILHSSHL-----------LLETS---------NFDNDKFIS-WLRSQLYPLGL- ------------------------------------------------------------ -----------ADC-------YTLITKLLVSS---------------NSGDVQLIEFI-- --------------------------DSSQLS-----ELSS-----VVVDRCLEC----- ------YATTG---------EERQVLLLAAKLNSPSVLSS--------MDVAAQLD---- ------------------------------------------------------------ ------EELLTMILCECITKDDQLHFLSSVLQ------LS-------------------- --------------------PPIR--VTSNMLIRMMHHADE------------------- ------------------HFFTTIVLCQCMGYSYIPSE---IDPRFA----NDIQKLVKK LS--------------------FGVDNLFDPNVF-CNDSS-------------------- ------------------------------------HRDKHE------------------ ----------------------------------------------SIRILAI------- -----WSLLL----------------------------HRPGI----------------- ----------------------------------------VKCLAAFADEP--------- -----VAFSMVLSRIARSLGHES-HDWH---------------FYEKSLNTLSDSLSGSA TTL---FDTVF-STSP-----------------------------------AKAYQLLCQ -------------------------------PMEYFYGFNMTQLAFH-----CNAREIIA HECCQRWVHRKLYGNLQAKNFPI------------------------------------- -------FLPKWAKICISAVLIIPVKF----------WMLV-RPR--ERTKQDTVSPTVA LL-DVG------------------------KFPQKQRAISTYSVISSRSEALT------- ------------------A-LTAPLSTAFG--F----NSALNGAES-------------- -----------------------ATPQSMVFPL-------NIEEIDKD--PRPFGKKNRI RRAHAPTLSTFYSTPIVKYW-------LS-------------LLFRIVFICCLAY----- -----SVVL--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGSNLWDTGM-WV WSFFWWIENCFVLTARA------------------------------------------- ------------------------------RKIPL------SLMPWRVFDVFAFFVFLIL LLVMKVFPVTPVLEVLG--I-----DSIYSAKVVS------------------------- ---AFFVLYVSYSTLFTYIPLSDIFGPMIVRVKLMLLRDFTNFLFMIALVMLSSAVAIQA VVFPDRPVTMEV---------------------------------------F-----RKT LSWIWLSLFT----------------TDLS----------------------NLSESETC RKSF-------LGAPK-----RYCSSVGQYANP------------SCPSQS--------- -LPAYLIVIEYFVILKLLLWPILFAFFSKTAKNVDDEADK------------IW------ ---RFQLYSLAEDFRLR----PPLPPPL-------------------------------- ----------------------------------------------------TIFCLI-- ----------------CSACCRFSNSFSGFFSDF-DHPDFEARDKCRTTWKFGSIYRNPS V---------------------------------------P--FKRNEFV-N-------- -------------------------------SFWRK--LSMEQWKNTQQKA-KISANKSE LQE---------------------------------------------------LHNIHN HIRMM-----------------------TLRDSYENSGTRKASEL--------------- -----------------------------------QFF---------EK----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------YPESNILKISVNMV- ----------------SKPWTVLVPR-----------YNPPFYCKPAED-FPS--DVQKY VDIATEQNVGEL-------------------------------------------KR--- ------------------------------------------------------------ -----IWRSRQANDV--------------------------------------------- -----------TSSNDKCWKLSAAGF-----PLNPNGRTGM----------------AGR GNHPR-------F-----GANRRCYY----------------------------VVLSGG V-EAKCQVL----------------VDSQK-NIPNEWHLENSSKDEHLTSILKMIGISDS DAHMFSM----------------------------------RRLDSSIITADKRIP---- -------------------------------------------------------SNDTS PAH--------------------------------------LA-------SEVAENENDT D-------NAWTEH-DVWAISLRE------------------------------------ -----RRIITTII--GYS------------------WLPTSAIR-GTVLPW--------- ---------QADL--------------V--FRAKTIYGL--------------------- ----- >Caenorhabditis_nigoni_PIC39172.1_TRPS ------------------------------------------------------------ ----------------------------------MDETDPA------------------- ------------------------------------------------------------ ------NVPDMSLLPDTVPVVVSGDGSA-------------------------------- -------AGIQLCPA---------LILGSPQALPGA------------------------ ------------------------------------------------------------ ------------TKHIYSRL-----------------------------A-------AAA SEVDQ-----------G--------------------VPDIIISLISHGNSL-------- -----------STKYMSQVENGLKSFLIG------------------------------C GTW---------------------------------IIS--------------------- SGEVND------------------------------------------------------ ----PLSRVASGALKNVLPQ-----------------LEHQAEVLHILVNS-------DD VMAS-------------------------------------------------------- -GSATSRSVVDTSLNTLLLICRKEA-----------NDSLEATAESIAKLRA-------- ---------------------------AAAVKL--------------------------- ---AHPPP--ALLIGVPSEPMS----------PSTY--GNSAAI---LLSPS-NDKRPFP VAVFAGASKE-------------------------------------------------- SLIELLFFVEHG------------------------------------------------ -------------IP---------------------------------------VVILQD SCELCAILHSSHL-----------LLETS---------SFDNDKFVS-WLRSQLYPLGL- ------------------------------------------------------------ -----------ADC-------YTLITKLLTSS---------------NSGDVQLIEFI-- --------------------------DSSQLP-----ELSS-----VVVDRCLEC----- ------YATTG---------EERQVLLLAAKLNSPSVLSS--------MDVAAQLD---- ------------------------------------------------------------ ------EELLTMILCECITKDDQLNFLSSVLQ------LN-------------------- --------------------PPIR--VTSNMLIRMMHHADE------------------- ------------------HFFTTIVLCQSMGYSYIPSE---IDQRFA----NDIQKLVKK LS--------------------FGVDNLFDPNVF-CNDSS-------------------- ------------------------------------HRDKHE------------------ ----------------------------------------------SIRILAI------- -----WSLLL----------------------------HRPGI----------------- ----------------------------------------VKCLAAFADEP--------- -----VAFSMVLSRISRSLAHES-HDWH---------------FYEKSLNELSDTLSASA TKL---FDTVF-SSSP-----------------------------------AKAYQLLCQ -------------------------------PMEHFYGFNMTQLAFH-----CNAREIIA HECCQRWVHRKLYGNLQAKCFPL------------------------------------- -------FIPKWAKICISAILIIPVKF----------WMLV-RPK--DRNKESTVSPTVA LL-DVG------------------------KFPQKQRAISTYSVISSRSEALT------- ------------------A-LTAPLSTAFG--L----NSALGGAES-------------- -----------------------ATPQSMVFPL-------NIEEIDKD--SRPFGKKNRI RRAHAPSLSTFYSTPIVKYW-------LS-------------LLFRIVYICLLAY----- -----SVVL--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGSNIWDTGM-WM WSLFLWLENCWVLGARA------------------------------------------- ------------------------------RKIPL------SLMPWRVFDVFTLLVFLIL LLVMKVFPAEALLDLLG--I-----SSIYSAKVIS------------------------- ---AFFVLYISYSTLFTYIPLSDIFGPMIVRVKLMLLRDFTNFLFMIALVMLSSAVAIQA VVFPDRPVTFEV---------------------------------------L-----RKT MSWIWLSLFT----------------TDLS----------------------NLSESETC RKSF-------LGAPK-----QYCNVVGQYANN------------ACPSQS--------- -LPAYLIIIEYFVILKLLLWPILFAFFSKTAKNVDDEADK------------IW------ ---RFQLYSLAEDFRLR----PPLPPPF-------------------------------- ----------------------------------------------------TLLCIL-- ----------------CSACCTFTNTINAFFSEC-DHPDFESRDKNRTVWRFGSIYRNPS V---------------------------------------P--FKKNEFV-N-------- -------------------------------SFWRK--LSMEQWKNTEQKQ-KTTTNKSE LQE---------------------------------------------------LHNIHN HIRMM-----------------------TLRDSYEKSGSRKASEL--------------- -----------------------------------QFF---------EK----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------YPESSIMKISVNLI- ----------------SKPWAVLVPR-----------YNPPFYCKPAEE-FSA--DVQKY VDIATEQNVGEL-------------------------------------------KR--- ------------------------------------------------------------ -----IWRSRQANDV--------------------------------------------- -----------TSNSEKCWKLSAAGF-----PLNPNGRTGM----------------AGR GNHPR-------F-----GANRRCYY----------------------------IVLSGG VEEAQCQVL----------------VDSKK-NIPNEWHLENSSKDEHLTSILKMIGVSDS DAHMFSM----------------------------------RRLDSSIVTADKRIP---- -------------------------------------------------------SNDTS PAH--------------------------------------LA-------SEVAENENDT D-------NAWTEH-DVWAISLRE------------------------------------ -----RRILTTII--GYS------------------WLPTSAIR-GTILPW--------- ---------QADL--------------V--FRAKTIYGL--------------------- ----- >Branchiostoma_belcheri_XP_019643532.1_TRPS -------------------------------------------------------MTCD- ----------------------LQGAEMVGRFPQVSSDDNSS------------------ ---------------------DDDGLKVSEVAA--------------------------- -------------EERTHAPPTSAHRTLS-------------------HRPRFRTKTRFP CFWKRHHASKYLTCCG----SDSEDSEEDDLQMELA-----------------DFLAEQN NQGSTTSLQFLLPQGSYME-------------------------GVL------------- ------PLRYGEEGRPYLLL-----------------------------NK------VNC PSMDVISEHLHRTWRIE--------------------RPKVILSLYCEPDYFSLW----- ----------KRRKIYDALQTGLIKLAST------------------------------T NMW---------------------------------LIT--------------------- NGANLG------------------------------------------------------ ----VGKLVGDALKREKARR----------EYVVVKEEDDQPTLRAVGILPFCAV---AQ MLPR----------WRVVQDE--------------------------------------- ---MKEQWELNPDHTHFIVVDD----------------GSNDNWTAEQDLRL-------- ---------------------------QLQHHY--------------------------- --------------------------------RSPRQVYNVLPG-----TTSRKKANPVV CVLVQGGPA--------------------------------------------------- SIQYVRGCVQQE------------------------------------------------ -------------TP---------------------------------------VLLLKG SGKAADLLAFAYE----------EIKERPA----------QEDWMQ--YLRAELSRRIF- ---KTFPQ---------------------------------------------------- --------LSQEE----VQDLKESIIDCVNDA---------------IKEDQVFLSILEV HS------------------------FHDDLE-----NLDK-----YILTAILKA----- ------QADVSD------DNVVQSDLQLTLQWNRPDLALS----------------EIFQ SPYFPDN----------------------------------------------------- ------IKIPSRLFEKALLKKDREEFVELFLS------QG-------------------- --------------------FDPANFMTRHRYRRLFEKAED------------------- -----------------REFIKGVF--GAMGY-NLPDF-GVLPEKFL----MTLKKVICR LAEVDVY----------------------------------------------FFCHESP N----------------------------------------------------------- -----KQRPSLEKAAIMCF--------------------SFQKKTKVMMDLLL------- -----WAILV----------------------------NKQRL----------------- ----------------------------------------VRVIWEQSEDP--------- -----IPLALYIRRVYMSLTKYV-EDA----------------TLRREMHALVTEYEDLA VGV---LDMGY-KEST-----------------------------------KKATDILNE -------------------------------MVPDWKVKTAIEVAYD-----SKCKKFIA HPCCQKWVKRKYMGGISVKKRMA------------------------------------- ------NIFPSWLKILLSAFLIFPMFL----------FIDF------------------- ----------------RFLR----------PSAEDQRRAQRKREILRGSQQS--QNSISQ SPVYPYVE----------RQVEEGCESSCRYCAGYRCNCTLNTCMLNF------------ ------------------------------------------------------------ ----FRRIKALWTAPITKYW-------AH-------------VLCYMIFLFLLSL----- -----SGLL--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGSALLDVGI-SL WMTTSIVELIRTIYR--------------------------------------------- ------------------------------DAEMFRRSSSREYNYWLYMETTLIVVFWVA HFFMKVVGT------------RVGFAHPKDAKLLM------------------------- ---AIMVFFFFLRLLYVFAPNSLLLGPRLVMLRKMIQIDLLVFFRLLVVFMCIHGVVSQI LLQPWHELDSDV---------------------------------------M-----KML VWRPWLHVWLTPYGY-----------LEGN---CEGLIVVPP------------------ -----------PNQPP-------------------SWYSPNVTMPTCPAET---SDACEG HWYLYLSLTFYLICVRFGLLTVLFAMFSKTYQRVQDESRE------------IW------ ---MYQRYKLIIDLDRR----DSLPPPL-------------------------------- ----------------------------------------------------VVFHYIYM LGRYL-------------CWCWK----------------CRIVTKVRVAYGEKTYSSQDM VDGGLD---------------------------------IPDGAELDEDK-F-------- -------------------------------SFWKS--CAHSYNSREKKKT-EQ-ENKQM --------------------------TQTDVYEQVSED----------------LSRLDV RVRRRHD---------------------RLHDRVVKVEKMMQESM--------------- -----------------------------------LTL---------ETIKHLLLKKESG -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VEGVPTTQTGAVLHI---- --AARQSP---------------------------------------------------- ---------------------------------------------YFGTSRKRFPVFDK- ----------------YVPWRKLFVE-----------YDPPRYTAPMEH-FSE--WFRQF ADE--------------------------------------------------------- -------------------------------------------------------VNPSA QQPAPVWNE--------------IVGYKMKIRHEGEGGTR---EEVMEVDRRSWIEDK-- ----------DTGVGI-RYNITSEGV-----PQNPMGRTGL----------------RGK GALFR-------W-----GPNHSMLA----------------------------ICTRWK HAVDPAT------------------GDEQEEYLLVEGK--------RVLEFL-SYKEPDF EEWA---------IPGAITAGLESKYSVLHRAFCTKALGKQPAVVDRNMDESKVKQ---- -------LFEAYTAD----------------------------------------EKDSP PTDRDDPI-------------------------ETFSAAM-IY-------RGYVDDPRNT D-------NAWVET-EAWHFHYESG----------------------------------- ----ERFSEEEMVTAGSR------------------WQEVSRHV--KLFAS--------- ---------HASV--------------IP-EAAARL------------------------ -NAYF >Trichonephila_clavipes_PRD37692.1_TRPS ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MNRTRK--------------HKRGKAYKF---- --------FR-ILR--------STD---------DVDKGD-------------------- --------------------------EDTPLED-----IPSA-----------TTEATSE EKPSVKRQLSFAVSETLGED----VVFRRF----------LATEGVLCFWKNFAYEDH-- -------------GRPFLRA-----------------------------A-------HDA -NMEYIANVLHQQWKIK--------------------SPRIVLVVVSNISHLHTW----- ----------TNKRQLEHFQAGLIKAANT------------------------------T EMW---------------------------------IFT--------------------- PGANIG------------------------------------------------------ ----ITKVIGDAVHNELLRR----QALLCHKHPNQS-VTLLPPLTLVGVTR-------ED LIV-----------YGDMLDG----------------------------RMQRVEIENEG NQPEENKFELNPDHSHFVIVRD----------------STINK-TGINHFLL-------- ---------------------------KLEQYL--------------------------- ---SSSE-----SLHC--------DI------DASTPRRHP--D---VCSLS-ANEIPVV SLLIQGGYD--------------------------------------------------- CARLILEHLKKQ------------------------------------------------ -------------LP---------------------------------------VVVVRG SGGLADLLAYAYY----------EVSERPR-------GIQDAEYVEN-SLKRELANKIA- ---HHFPH---------------------------------------------------- ---------LREN-NLARNLFRDRIMECVRYA---------------HQNGQVYLTVLNL HS------------------------HSCKLE-----DLDE-----HLLRALFKS----- ------QRPDL----TSWHAQMQKDLLLTLDWNSPHVAMS----------------EVFL KDPSNK------------------------------------------------------ ------FKVDKSIFEQAITRANREDFVDLFLK------QG-------------------- --------------------FQIHKYLTPKRLKYLFLKSKR------------------- -----------------QEFFRSICWEGALGH-GLITK---FGKNFI---DNDLNLLIEI CT---------------------GIHNFVSTQEMSVNAMG-------------MYTVDPS A----------------------------------------------------------- ----------AERKSLCIL--------------------------------IL------- -----WAVFT----------------------------NKPKL----------------- ----------------------------------------AKLLWQHSEQP--------- -----IHVALIVSMIYEKLQDYV-NDT----------------NVKQELHNLSREFSEMA TGV---LDASY-MDSS-----------------------------------CRAYDVLSE -------------------------------ETSDWSYKTAVDIAAN-----AKNRTFLS HVCCQKWLSNLFLGNIRIRDVTWGVV---------------------------------- -------TFPQWFKVVLCAFFIFPMYI----------WIRF-KTDPL------HSWDVHP ST-DV-------------------------DSDDERDERDGEDEILIDANQGK-ENDFIR ------------PRGSV-VCLKGQDRSPFDFGH-GHHREQVAT-----------LLREKE VFIHSP------------------------PPL--------------------------- ----CRMIYLMWSAPITKFW-------TF-------------Q----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KY---TS-VPLFFKCLEILLIIAFIIL YVLGRIL---NVGVIFD----------PYTGKVIL------------------------- ---CIGLLYFFYRLIAIYLPISPTLGPLLYRVRLMVLVDFVNFMRMTLLVIISGGIVLQA VLYPDYPLSIEL---------------------------------------F-----RQT FHRAWFSLFLTPIGE-----------LE-------------------------------- ----------------------------DS-DY------------TCPSTG--------- -LWPYLFAIQYFVFLKLILLTLLYALFSATASKLESETDA------------IW------ ---KFQRYQLVVDFTNR----LRLPPPL-------------------------------- ----------------------------------------------------SIFSYLII VVQ----WLYR-----C-ILCRL----------------CKSRDEADVNVFFDSSK-GHR L---------------------------------------------SEKD-Y-------- -------------------------------NYWRQ--LAQDYTKEKMEA-----ENEKQ -----------------------LAKKQMEM----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Octopus_vulgaris_XP_029638531.1_TRPS ------------------------------------------------------------ ----------------------------------MDNNGS-------------------- -------------PKSW-----KKLAFLNRNDQ--------------YRPIDMYND---- --------NRSYTD---YEDSIYPDRNQFFLDGESVNQSVV-------SSLRGISRDSF- -----CMSTAHI--------------AEDPLELLECGGINDE-----------EQGSYYP E-VEPVQRTVDS-AGAVSVDTQDSGLFKDS----------PLPCGNIQFWSESTDPTDF- -----------QSKKHYVCV-----------------------------P-------TDT -SVEDLADFMGLFWRMR--------------------SPKIVLSVVSGIKHFKGW----- ----------KNPKLKEQFQKGIIKAANT------------------------------T ELW---------------------------------IIT--------------------- NGVDGG------------------------------------------------------ ----IAKTIGDAIHEEKIHR-ISNRVQQAYASIHAEQCHRLPKLTVIGIMP-------KH CIS-----------YESSFDG---------------------------LYDGPIVIKNEG HKPNSNCYDLNPDHTHLILVED----------------EVGER-SIFTHFRC-------- ---------------------------LLEYRL--------------------------- ---GSE-------LGRPHRFKRFF---------SNESFEMEMQ-----TETP-AASVPVV GLLVQGGPK--------------------------------------------------- SIDHILFFLKNK------------------------------------------------ -------------MP---------------------------------------VLVLKG IGGAADLVAYTYE----------ELQERS-----------DQDFTDN-SLKPELIKRIS- ---KTFPD---------------------------------------------------- --------DFKEN-DIARNAFRDKILECVKYS---------------QEGEQTFLTFVNT KG------------------------WDSNLK-----DLDK-----YILKALFRS----- ------KILS----GSQWREQLYKDLQLTLDWNRPDLACS----------------EIFQ REEFGK------------------------------------------------------ ------LKIDKNLFDQSLQRKDREDFVELFLD------QN-------------------- --------------------FQVHKFLNHKKLKLLFEKAEE------------------- -----------------REFFYTTCLEGALGK-NFQSRDQPLAANFL---DTDLNRLIYK LC---------------------GIKDFVQPCELSMNSLG-------------LYVLDPV V----------------------------------------------------------- ----------AERKAINCL--------------------------------IV------- -----WAVLM----------------------------NRNKL----------------- ----------------------------------------AKLLWGRSDDP--------- -----IPIALICSDIYKRMATF-SMEL----------------YQRCEMEQNASEFGKMA LGT---LDISF-RDSS-----------------------------------AQAYSMLSR -------------------------------PLPDFNNKTAIEIAHD-----SGYLHFIA HPCCQKWLTKKLFGSIQVKELDWGVF---------------------------------- -------RLPYWFKILASVFLVLPMYI----------WIAF-VPS--------NTNQSKL KV-DI-------------------------DLREEEIDEESGSDSSEDNRLPQ-SKSMLE ------KEFR--RNGK--RSVGARLRTALR------------------------------ -----------------------RKRK-LKLPF--------------------------- ----WRQIYLLWNSPITKFW-------MT-------------QVFYFIYLGIFSL----- -----AVLW--------------------------------------------PT----- ------------------------------------------------------------ -----------------------------------------------CGNILLDLIV-WL WTLVIVTEIARRTYI--------------------------------------------- ------------------------------KHQKY---KA-LSLLGHCVEIILILVFLIL YLILRIIPN------------WVNFSDFITAKIVM------------------------- ---AIGLIYFFYRLLGVYLPISPTLGPNLVRIVRMVKHDFVAFIRMFLIFLLAGGVTTQA VLYPNYPLGIQM---------------------------------------L-----KNV LTRPLFALFLTQIQD-----------LDGF-KDCTPL------------YK-NIS-PGYC TTKKTS-------SPF----------VSDA-G--------IAAVATCPYSS--------- -LGGYIVVLQYLIICKLILTTILFAMFALTISKVDNEASS------------IW------ ---KFQRYALVVDFEER----LCFPPPL-------------------------------- ----------------------------------------------------TFLSYFAM LIRLIYRKMKKCKRN-CEFFCK-----------------CWKK-SALPEASSSSHRASQR L--------------------------------------------KRSED-Y-------- -------------------------------SYWKK--CAKEYSLTLETQ-----QKMSE -----------------------FPKKQAEIVNNLKDD----------------MQLQKK NIK-------------------------RLSDRVVELERALQTSR--------------- -----------------------------------IYL---------EDIKHMLDKSD-V -Q-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VSS----TKGQSLHV---- --ASRQSP---------------------------------------------------- ---------------------------------------------YPGTKLARFPVFDK- ----------------YVPWESIYDV-----------YDPKTYTKPKDQ-FLE--YEIVF VDEDIFELRAL--------------------------------------------EELRA QMTEEERAEQPA---------------------------------------------LPN FRP--MWNA--------------VVTYRQG-------------NATREVDRRSWIT---- ----------IDSQPV-RYKLDPSGV-----PQNPMGRTGI----------------RGK GSLWR-------W-----GPNHVIRG----------------------------VVTRWR RKYT-------------------ADFQP-TNYLYVDGK--------RVLEFI-AVRKEDA DEY-------LFCLPGDALHGLTSPYSTMCEAFMKSVFDEHDVDSKTELDQTDMIQ---- -------FYAQFATST-------------------------HCPRSS--------ASLSS P-SRSTSQ--TMLPML--SGSRTSLRT--EQDNQGFSACL-LY-------KGYVDDPRNT D-------NAWVEA-EVWNFHYDFADTFDSRIL--------------------------- -------EDASV-----K------------------WKEVSPYV--KLVGN--------- ---------EAVI--------------VQ-EAA-----------RIHD------------ --AYN >Mizuhopecten_yessoensis_OWF47104.1_TRPS ------------------------------------------------------------ ----------------------------------MSESSN-------------------- -------------KE-------------RHTAS--------------YVPVAL------- ------------------EPAGSPDVGPKCRIG-SVVRSAS-------TTIYSPSNSN-- -------ESSIV--------------DGDP-----------S-----------ETGYFFD EDADLNQRTVTS-FGGLSIDTQDSARYNDA----------PFDCGNIQFSDVNSQKQER- -----------EPKRHYVCI-----------------------------P-------SDT -VSWDVAHFLGSYWKMR--------------------SPKIVLSVISGVKHFKPW----- ----------KNLRFKKQFQKGIIKAANT------------------------------T EMW---------------------------------IVT--------------------- SGLDGG------------------------------------------------------ ----VSKMIGDAIREEKARR-ISNRTQQSM--IRPDAVQKFQKLTLIGILP-------KD GLK-----------YGDKLDG----------------------------SEG-VGLKNEG HQPDSDKYELNPDHTHFMIVEE----------------EDLDR-MLFTNIRC-------- ---------------------------TLEKAF--------------------------- ---EYQ-------LGRPRRLRRVFSWGSD---ESNTSGFNDMH------QPN-DKTIPVI GLLVQGSPK--------------------------------------------------- NVEHILFYLSNK------------------------------------------------ -------------MP---------------------------------------VVVLKG SGGFADLLAFAYQ----------ETQERT-----------DPDFLET-FLKPELIKMIS- ---KTYPS---------------------------------------------------- --------DFKDN-DLARNEFRDKILNCVDLA---------------QEDDQTFMTVVNM QG------------------------WDANLK-----DLDK-----YLLKALFKS----- ------EKQV----ASKWKEQLYKDLQLILDWNRPDLVQS----------------QIFQ RDDFAK------------------------------------------------------ ------IKLNKELLEKALLKTDREEFVDLFLD------HG-------------------- --------------------IQIHKFLNHKKFKLLFERAQE------------------- -----------------REFFTTICLEGAL---NFSSVVSINTKEFL---SNDLNRLIYK LS---------------------RIKDFVQPYELSMNSAG-------------LYVSNPA V----------------------------------------------------------- ----------AESKALNCL--------------------------------IV------- -----WAVLM----------------------------NRHKL----------------- ----------------------------------------AKVLWQRCEEP--------- -----IAMALICSNMYRELAKN-CIEL----------------YLRTEMENNANDFGKIA LGV---LDISF-RDSS-----------------------------------AQAYNILCK -------------------------------PLPHFNNKTTLEIAHD-----ANYMNFIA HPCCQKWLTKKLFGAIHVKEVPWGIF---------------------------------- -------RLPYWFKILASVFLIFPMFI----------WINF-SPGALRRVKGITVNDTIL ME-D----------------------------EEEEEGETTDSNDEEDAGLPS-SKSMLE ------NELSNMRKAKSLKSVKVRIKSAMK------------------------------ -----------------------SNKK-RHLAL--------------------------- ----WRRIQLLWSAPITKFW-------LT-------------QALYFVYLGLFCL----- -----AVLW--------------------------------------------PT----- ------------------------------------------------------------ -----------------------------------------------CGNLTLDLIV-WL WTAVILTELVRRTYV--------------------------------------------- ------------------------------KHQKY---KT-VSLFSQCAEITFILIFLIF YLFLRIIPH------------WLVYANINAAKTVL------------------------- ---SVGLIYFFYRLLGTYMPISPTLGPMLVRMTRMVKHDFVAFIRMFLIFLISGGVTIQA VLYPNYPLGYDL---------------------------------------I-----KKV LTRPLFAMFLTKIDD-----------LDGT-PACNAY------------NDANMS-THHC LAEPTQ------PGPE----------LPD-------------HIISCSVGS--------- -IGGYLIVIQYLLICKLVLVTLLFAMFALTITKVDKEAGQ------------IW------ ---KFQRYALIVDFEER----LCLPPPL-------------------------------- ----------------------------------------------------TLISYITM VLVFFYSQLFGCHKG-C-LCCC-----------------CFKK-QAKRKKTEKMVHKVQR I--------------------------------------------KQSQD-Y-------- -------------------------------NYWQK--CASEYITTQDNE-----QESQT -----------------------IVNKQTEIINSIQED----------------MNFQKK NMR-------------------------LLNNRIVELEKIMLSSR--------------- -----------------------------------MYL---------ENIYHKLDKTD-V -F-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VSN----TKGQIIHI---- --TARQSP---------------------------------------------------- ---------------------------------------------YPGTRIARFPVFDK- ----------------YVPWEQAYDV-----------YDPKIYTKPKDQ-FCE--DEMVF VDEDLIQLKKA--------------------------------------------QEERD RMTEEEKESLPP---------------------------------------------LAK FSP--KWNS--------------VVTYRQE-------------SHTRAIDRRSWIS---- ----------FNNQPL-RYSLDPMET-----PINSMGRTGL----------------RGR GLLWR-------W-----GPNHVIKA----------------------------VCTRWR HKYSDN-----------------EDAQ--TGFLYVEGK--------RVLEFI-AIKKL-G DEVTMD-SGSTYGLPGGALHGHISPYSMQCQAFMRDVLME-DQDPKNNLDQADMIQ---- -------YFAQFSANV-------------------------STPVRTP------VTQLPS PVSSATTQMSSIQPFLTRTNSRTSLRTHGDGDSSGFSASL-LY-------KGYVDDPRNT D-------NAWVEA-EVWNFHYDAGDTFDSTIP--------------------------- -------EDSSP-----T------------------WKEVSPNV--KIFGN--------- ---------EGAI--------------VQ-EAA-----------KIHD------------ --AYH >Mizuhopecten_yessoensis_XP_021360214.1_TRPS ------------------------------------------------------------ ----------------------------------MASQSS-------------------- -------------DS-------------NDNLD--------------YPEVAI------- ------------------------------------------------------------ ----------------------------DP------------------------------ -----VYATVTSNVSWFSTDSQDPSWIEDL----------GFSGGVIQFVYDEASGQKA- -----------NAGL-YVSV-----------------------------P-------EAA -DADDVATYMAKVWKKR--------------------TPNIILSLITSNRHYKHW----- ----------KDQDLVHDFQTGIIQAANT------------------------------T EMW---------------------------------ILT--------------------- NGFDGG------------------------------------------------------ ----ITKILGDAFKEENQRRKIQSLTKVSMKFVDNQKQENLPKLTVIGVVP-------KC LLS-----------YNSKIDS----------------------------AAGPVNIQNKG EKPLSDKQELNSDHTHYIMLEG----------------VTDLR-EL-ENFRI-------- ---------------------------RLEERF--------------------------- ---LTP-------VGRPKRYRKITNL-SDSVLNVGESVPDDLQ------IIS-STCTPMV GLLVQGGPL--------------------------------------------------- EMDHVAELLKRN------------------------------------------------ -------------VP---------------------------------------VVVMKG TGLAADLISFAYL----------ELQERP-----------HPEHIES-YIKPELIKKLM- ---KYFPE---------------------------------------------------- --------EFKED-EIARNRCRDKILECAQYA---------------HQGEQEFLTILPT DG------------------------ASSDLK-----NLDK-----YLLLALFKS----- ------QALKR---GRKFQEQFQCDLKLTLDWNRCDLAVS----------------QIFQ KYDWAR------------------------------------------------------ ------IKITHELFDRALLKKGREEFVDLFLQ------RDA------------------- --------------------IQVHKYLNHRKLLFLFNNLEN------------------- -----------------EEFFLTVCLDGVLAKASYSSY--PLDKDFIIGDDCDFNQLLYR VT---------------------FLQRLVSSYELSMNSVG-------------SYVTDQE V----------------------------------------------------------- ----------AERRAINTL--------------------------------VF------- -----WAAIT----------------------------FNPEL----------------- ----------------------------------------TKVLWKRTEDP--------- -----MVMALIVSMIWNSLSKNWCRDL----------------DTKRKVRESAIDFGKMA VKL---LDLAY-KDSS-----------------------------------VVAINALGK -------------------------------KLPDFNDKTVIEIAHI-----ARNKFFIA HTICQKWLDKRWNGKLQIRELEIGPF---------------------------------- -------KVADWLVLYLSVFLVFPMFL----------WITY-D----------VKNDS-- --------------------------------KDESNLDDSDDEIPLDEGIML-QPSALQ ------GEKW--KQKR--HSVKYQMRKMFD------------------------------ -----------------------YGRQNLKVPV--------------------------- ----YMQFYYLYSAPITKFW-------VS-------------QLFYILYLTIFSL----- -----AVMF--------------------------------------------PS----- ------------------------------------------------------------ -----------------------------------------------CGNLHMDFIV-FG WTLLIWVELVRGVLA--------------------------------------------- ------------------------------KKKKY---LE-MNLFWTKMEIGLIGIFLIL FCLVRIVPH------------FVSFIDYMTTKFVM------------------------- ---SLGLLYFYYRTLQVFLPISPVLGPMLINIRRMIKKDFVTWMRMFLIIMVSGGVTIHA VLYPNYPFTLHG---------------------------------------I-----KKA LTRAFFTMFLTQIDD-----------LEGN-DSCSDQ------------YK-NTS-LTHC RAI----------SPD----------IFSK-NASSTTRDDVTSLDTCPYSS--------- -MGGYLVVMQYLVITKLVMITLLYALFSATTAKVRGESEE------------IW------ ---KFQKYSLIVDFEER----LRLPPPL-------------------------------- ----------------------------------------------------SFISYLCM MAVGFYHCFHRC----CSLCCRRP---HGCCRC-----TCKKK-KGRTEKDCSKLR-VLK V--------------------------------------------RRTED-Y-------- -------------------------------NYWRS--SIKDLMDMEEQE-----KADRE -----------------------RPKTQSKNIGVVMVQ----------------MEKQKH FNG-------------------------KLTEQMARLERSVTTCN--------------- -----------------------------------LAL---------EQIKHLLDKQ--- -Q-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------QKNLNVAMKRSLVHV---- --SSRQSP---------------------------------------------------- ---------------------------------------------YPGTITQRFPVFDK- ----------------HVSWEVPYLG-----------YDPVVYTGPLEE-FVE--AIQPL VDPDFLQISRT--------------------------------------------VEEKL LSREDIRTQHQP---------------------------------------------SAL YCP--MWNV--------------SATLKIN-------------NALVEINRASWIT---- ----------QNSTAC-RYSIDKTNL-----PLNPMGRTGI----------------RGR GKLWR-------W-----GPNHSVLV----------------------------VLSRWK EKYKLN-----------------GTVAPERDYIIIEGK--------RVLEMI-VIQRLDT GEFT---------LPGGNDYGNMSMYSALCKRFQQFVLDQ-ETTAKENMTEQDMIN---- -------FFSKFSV---------------------------------------------- P---------------------------GSGPNTGMTSGV-IY-------KGYIDDPSNT D-------NAWREA-EVWNLHYRGGSILDD-IV--------------------------- -------KEKEK-----K------------------WKEASSYT--KLYGN--------- ---------QDMI--------------VK-EAA-----------LLHG------------ --AYY >Pristionchus_pacificus_Ced11_PDM65852.1_TRPS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MGDPHVFADSISISTPN------------------------------------ --------GIQLSPC---------IVLSSPIAIPQA------------------------ ------------------------------------------------------------ ------------VKYIYSQL-----------------------------A-------ANA NELDE-----------G--------------------VAHLQISLISHGNNL-------- -----------SQGYRDVLSLSLLSILSE------------------------------C STW---------------------------------LLT--------------------- SGEITD------------------------------------------------------ ----PFSSIATSLIQKALPH-----------------MREGNEMLHLPIGC--------- ------------------------------------------------------------ -IPTDDQMRVDASFNTLFVLSR----------------TLVDTPESSSRFRA-------- ---------------------------HFSSRL--------------------------- ---SKPPP--ALLIGMPGEFSS----------------SQAPAI---LLSPSANEKSPLA LSIFAGSSSV-------------------------------------------------- SLEELVTLLESG------------------------------------------------ -------------IP---------------------------------------SLILQD SCELCSLLHSGWL-----------LTRSS---------HFSPSSFSS-WIESSLENLFS- ---D-------------------------------------------------------- -----------SDSS--LPILSSLVNRFFSAA----------------LSDQPLVEFI-- --------------------------SKRDLP-----HLSS-----HLLHLC-SL----- ------NGTSS---------QEQRILITAAKLNCPSILSS--------LS-PDMGD---- ------------------------------------------------------------ ------YQLVESLLCECTSRDSRIDFLSSILS------HS-------------------- --------------------IDLP--ITSNLFLRMLNSTDK------------------- ------------------HFFCTVVL-PLLGYSSPPTV---ITEEFT----MVIDQLIMD VT---------------------GHRGFF-PSLSDSHSFS-------------------- ------------------------------------HSS--------------------- --------------------------------------------------LAI------- -----WSLLI----------------------------HRPNLVLTPFSLHSLLHY---- ------------L---------------F----------QVSLFVSFSPDS--------- -----LPLSLLISKLSRYLSRES-EDWF---------------FYSESLISLSRSLSRFS LSV---LSSIH-CESP-----------------------------------TESYRTLCV -------------------------------SLPSFGGCTLTQLAYQ-----TSSRLLLS HDCCQRWIHRLLYGRLQLRPLLT------------------------------------- -------FTPKWFRIVISASLIFPIRH----------FLSL-RPPSLLYRQSPFKSPTVC LLHDIRYSLNRLFLLYRILLLVPSRALLHFRQPRRSRALSTYSVISTRSDLLS------- ------------------AHLSTGIPQPV---------ALLPQTGQ-------------- -----------------------STPQSAIMPM-------SFDEMDSNLICALSPHKPLI HSAISPSLSTFYSTPIVKYW-------LS-------------LLFRLIYLIVFGY----- -----SVLL--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGSLPLDTIV-WL WTFIWWIEAVWVAHSFS------------------------------------------- ------------------------------KILSI------SSMPWRIFDIIIVFIFLIL IAITRIT-VKDIMKLIG--I----YASAYPYRTLE------------------------- ---AFLLLYQCYATVLFYIPLSSQFGPLMIRVKIMVLRDFTSFLILVGLIMLSSGISLFA LSYPDRIFSFDS---------------------------------------I-----RSL LSWTTLSLFT----------------NDLS----------------------SLSLNEQC KKTA-------LSRPA-----AYCTMLNSNREA------------MCPTQS--------- -WPVYITLIQYFIALKLILWPILFAFFAKTAKAVEEEADV------------IW------ ---KYQMYGLVQEFSIR----PPLPPPL-------------------------------- ----------------------------------------------------TPFFFL-- ----------------FIAFCRKGLQTAQSLSS--DHPDMGEKTWSRP--ERGGVYRNPS V---------------------------------------P--QRGGS---D-------- -------------------------------ATWKE--AAIKEWKKSRAKI-EERSEEKE --E---------------------------------------------------LGMIAE QLRAI-----------------------ALRNSMEK--KRDKMSR--------------- -----------------------------------SLY---------S------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SSSSISRLLVPPH- ----------------LSRWEIVLPS-----------YSPPFYSKLHDE-FPL--HQQNL VDSTTQQSMDEL-------------------------------------------RS--- ------------------------------------------------------------ -----HWRSRQSTSL--------------------------L---------SSW------ ---------SSSSSPSSSILLSSSGL-----PLNPSGRRGI----------------SGR GNHLK-------F-----GPNPLNIY----------------------------II---- --TMDDQIL----------------VTSPTVSLPSEYRFDQGSRDDTLLSLLKLIGIPET EATVLCI----------------------------------R----------DETG---- -------------------------------------------------------RGESS PVK--------------------------------------VL-------SRISPCEDDT D-------NAWREE-EVWKVGLRT------------------------------------ -----RVVTTEMI--GYS------------------WISLDTAS-SQLSKS--------- ---------ELEI--------------LSTHSTKHKYFFPFN------------------ ----- >Ancylostoma_ceylanicum_EYC40953.1_TRPS ------------------------------------------------------------ ----------------------------------MDDSETS------------------- ------------------------------------------------------------ -------VTDLSVSPESAAVAVGG-GGV-------------------------------- -------GGVQICPA---------IMLGSSQALPGA------------------------ ------------------------------------------------------------ ------------AKHIYSRL-----------------------------A-------ANA AEVDE-----------G--------------------MPSLIVSLVSNGNQL-------- -----------SEKYLSRFQSAISVLISG------------------------------G GLW---------------------------------LIS--------------------- SGEHHD------------------------------------------------------ ----PLARSASSALRAVLPQ-----------------IERDVEVLHVIVNS--------- MAVR-------------------------------------------------------- -AREEGRLMVDASLNTLLILSR----------------NIEASEES--TFRA-------- ---------------------------NAVVRL--------------------------- ---AHPPP--ALLIGVPSENIT----------SGTTPSGNAPPI---LLSPS-NDRRPLP AVVFAGASLA-------------------------------------------------- ALQELLVYVENG------------------------------------------------ -------------FP---------------------------------------IIVLED SCELCVVLHSAYL-----------LYRSP---------QFDHSKFVA-WLEEQLDAVSI- ---EN------------------------------------------------------- ----------VAEA-------SKIIVGIFATA----------------FGDTQLIEFL-- --------------------------DSDEMP-----SLAA-----RIIELCFQC----- ------HSGST---------EARELLQLSAHINEPSILNE--------VDLDDLLD---- ------------------------------------------------------------ ------DELMTAILCETVAVADRVAFLAAILE------RR-------------------- --------------------PQIT--VNSEMLLKMARNSDQ------------------- ------------------HFFTTVVLCQCMGYSSFPDE---LDDKFI----NDLNKLLRR LS--------------------FGVEELIPPTALSCDFMQ-------------------- ------------------------------------NRDPAD------------------ ----------------------------------------------AIRVLAI------- -----WCLLL----------------------------HRPAI----------------- ----------------------------------------VRCLCAFSDQP--------- -----VAFALVLSRLAKSLARES-HDWF---------------FYEESLLKLSDSLSNSA VSL---VDKVH-QTSP-----------------------------------NKAYQLLCQ -------------------------------PLEGFQGATLSQLAFQ-----FNIRGLIA HESCQRWVHRLLYGQLQT-CSSS------------------------------------- -------ILPRWMKTLIAAVLVLPIRW----------WMCV-RSNLAVHSAPDKKSPTAA LL-DMG------------------------RQPKRVRAVSTYSVISGRSDVLS------- ------------------A-VAGGHSI-----------PQLALTES-------------- -----------------------ATPQSMVFPL-------NIEDVDGE--DAVFTKKPRI SRRTPPSLCLFYSTPIVKYW-------LS-------------LLFRLLHIGLLAY----- -----SILL--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGNLTLDAVV-WM WTFIAWIEAVWVLNMRN------------------------------------------- ------------------------------HTTPL------SLMPWRVFDCVVTLLFLVA MLLFKFVGDSPISDFFL--L-----STVYPIRVLS------------------------- ---AFFLLYWCYATIFFYIPLSELFGPIVVRVKLMILRDFTNFLILVALVMSSSAAAIHA VLYPDRDISLSV---------------------------------------A-----RSS LSWVWLSLFT----------------TDVS----------------------SLRESDVC KKSF-------VGSAT-----SYCHLVGEYGNT------------SCPSQS--------- -AAGYLVVLEYFVLLKLILWPVLFAFFAKTAKSVDDEADK------------IW------ ---KFQMYSLVTEFSLR----PPLPPPL-------------------------------- ----------------------------------------------------TPLFFF-- ----------------CMACCRAGGQLGGMMSSYPDHPDVDHRDRSRCTVRFGSVYRNPS V---------------------------------------P--AKKNEFV-N-------- -------------------------------SFWRQ--LMIDRWKEETRPK-HDFSGKAE VKK------------------------------------------------------VQN QLRML-----------------------ALHNTYSAGERRHRLEV--------------- -----------------------------------DFV---------Q------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------YADTDVKRLAVPPA- ----------------ERPWQILLPR-----------YSPPFYCRPAEE-FPA--DTAKH VEVATEQNVTEL-------------------------------------------RR--- ------------------------------------------------------------ -----IWRTRQAMD---------------------------------------------- --------------SCKGWMLSAAGY-----PLNPHGRRGI----------------AGR GCHPR-------F-----GANKRCYY----------------------------IILTGT S-KADCKLL----------------LDAHH-NLPNEPHPESGSKDEHLASLLRTIGLPES DAQVFSM----------------------------------RRLDSSIVDSSELVP---- -------------------------------------------------------TTDTS PAH--------------------------------------IA-------RLAIEHDIDT D-------HAWTEH-DLWAISLRN------------------------------------ -----RRVLHSII--GYF------------------WHPLSS-P-TSLSAT--------- ---------HEEM--------------L--NKTLRVYGIT-------------------- ----- >Parasteatoda_tepidariorum_XP_015907226.1_TRPS -------------------------------------------------------MNV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EFGKC-----------SLKRTSA EESTPEKFQQSKKEDNFKF-------------------------GHL-YDGEHTEKAK-- -------------HLPFMLI-----------------------------H-------HTV -PMDTVISEMLHEWKIH--------------------LPKIVLLIISGSKNHCSDY---- ---------HKVRKLKSLLTEGLVNALHT------------------------------T ETW---------------------------------VCL--------------------- DSLDRE------------------------------------------------------ ----FGRKLGKEHEKETYHRKVLMKSMQ-------KRDSFYPNSALIGVCA----TNKVN VVEK----------FGLEDSEDH------------------------------------- ---GKENGNLNKHLNYYIFVQA----------------KKEQSKRNEEFVIL-------- ---------------------------NFIKYL--------------------------- ---GQD-----KRIGNTG-------------------------------VQD-DRSIPIM AIICQGDLE--------------------------------------------------- QIDLVLKCMKNN------------------------------------------------ -------------FP---------------------------------------VLVIQG SCGLANLLFFTYS----------QVIRRPE-------STNEAEYLET-VVKPQVVLEIN- ---RHFPN---------------------------------------------------- --------LYNSG--VSDRKLCSKLIDCIRYS---------------KQGDREFMTILKP SD------------------------LETSSE-----SLTT-----FLLKASLKS----- ------QLEVQ----SKDFHHVKDNLLLAIDWNCPEAART----------------EVFS KDVTSK------------------------------------------------------ ------LHADHEMFAKVLIAPRREEFVDMFLS------QG-------------------- --------------------FKVHKFLDGDTLTNLFAVSLN------------------- -----------------REYFRTVIWETVFGL----GKTAVMSRHFI---DTKLIKLLQK LT---------------------SIPDIISTKTLDQNARG-------------MYSK--- ------------------------------------------------------------ -----YSSTHAEQKALVAL--------------------------------AI------- -----WSILS----------------------------YRISL----------------- ----------------------------------------AKVIWKYSAQP--------- -----IHLALVYSIILNKTQYSI-PEF----------------ILNDEIKKDVMEFNLMA AEL---MALCY-EKST-----------------------------------QRGLNLLRD -------------------------------KDDLWSFKPLLEIAAF-----AKNRQFIA TECCQLYLDNQLNGRLIIKDLPYGDF---------------------------------- -------TVPKGVKIILAALFVFPMWF----------WVDP------------------- ---------------------------------PEVETASTESNELKQIENNI------- ------------------EKIDSKT----------------------------------- -----------------------FIKRDLGSAL--------------------------- ----LKSIYNLYSSPICKFW-------LC-------------QVFYAIYLFLFSI----- -----AVLW--------------------------------------------PS----- ------------------------------------------------------------ -----------------------------------------------CGNPRLDFWM-SV WTGVIIIDALYQIII--------------------------------------------- ------------------------------------LPES-ASLKLRYIEVLWMIIFFLC YTSNRVLMY----------K---NFITPYVIKVIL------------------------- ---CLALLFFFYRVIFRAFTLSPKLGPMLYQIKRMALVDFLGFIRVTALIMFSNGVVIHA IIYPDYPFTYEL---------------------------------------F-----KRI FYRTALSLFKMTVPE-----------LGTVHPKCIRLKRSPNGLSFY-----GLP-DYEC RVGK-------YFLPE------------------------------CPNPG--------- -IWPYVFSFQYFLLLRIVLLTLLMALFSNTQTRLAEVGTE------------IW------ ---KYHRYQTIYDFSNR----VAFPAPF-------------------------------- ----------------------------------------------------SPIMYCIK FFKCIYSFL------------------------------CRTKSRKCRA----------- -------------------------------------------GAMKEED-L-------- -------------------------------QYWKD--LTSDYYTRNLKET-VRVENSSK --------------------------SRIEKWIFLKEE----------------IGKQKL MIR-------------------------NWQGHLTDIQIRSKHTY--------------- -----------------------------------KVLR-------NSQLQVSLRKRLGM -E-N-------------------VPQLF-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SRISP---------------------------------------------------- ---------------------------------------------YPNTQVFRFPVSDK- ----------------RVQWSNSWQN-----------YEPIAYTMPKED-FSP--DVRPY VDIDIQRIREA------------------------------------------------- ----------------------EGDDFK-------------------------------- -MPMFQWNTSSVS------------------------------PVGISYNRLSWIRNKFG N--PF------------MYSLDTDDL-----PMNPQGRTGL----------------RGR GYLPR-------W-----GPNHHIYV----------------------------IVTRWQ EVESA--------------------------------------FYHQYLEVV-------- -----LSTKDDLFLPGGFVTS-ENPYSTIRTIF--------QAIDEWFSEE-DMLD---- -------FFKSLSSD----------------------------------------IHVTK AKNRRASI-------------HGKTQSAGVEENDAMISER-VL-------KGYLDEAVNT D-------QAWCEA-EVWHVHYDGLCKID------------------------------- -----HYFDSDF-----K------------------WVVLNEEILNRVPPG--------- ---------QAYL--------------LN-HVAKKM-KASLDVL---------------- ----- >Dermatophagoides_pteronyssinus_XP_027204088.1_TRPS ------------------------------------------------------------ ----------------------------------MNNSQN-------------------- -------------PMND----EDDEIYLSQESS-------------SAEPKNSLKLGTSS ----GTGGFQSIVKRIQLAARISQQGNQH---GDCYDEDAKLNTYLKQTKLATRRRSR-- -------RSGSI------------FPLPTPL------PTPLT-----------GQLNTIQ ESPFEFQQTRPS-----------------------------FILGEIHFL----HKDHQ- -----------YDFKPFVAL-----------------------------E-------PHI -TLNDLSRILLEEWQLE--------------------MPKIVTLIVTGKSQNSRW----- ----------KNEKQIKNFQIGIAKAAMS------------------------------T NMW---------------------------------ILT--------------------- NAVNGG------------------------------------------------------ ----VTSYVCSAIEREFQKAKLKGRL-----------YQQVNSFHLIGIAH-------EN HLI-----------YGRKLCYIENALVSLMFFLGVIXHCFIGMHRFFRFIXNLFNIENTG FN-DGHRFELNPDHTNFIVLKN----------------FLYN-----NDFIM-------- ---------------------------KLIDLF--------------------------- ---NIKDC-----VNNHDQKQS----------EHTKSAKNS--------DEN-NADTPFV SILIDGEPE--------------------------------------------------- NIQLVLQLIKKR------------------------------------------------ -------------IP---------------------------------------VVVLQG SGGMADIVSYAYA----------RIFDSFV-------DSIDKDYIDK-NVKPLLDKKII- ---QQFNE---------------------------------------------------- --------LEDENKNNERNRICQQVIECVCLTKQH-----------RRQDGREYLILLDT YN-----------------------INQGNLT-----NLRE-----YLLNAILKS----- ------KHRNV---DRPYGEQFSKDFDLIVDWNCATVARN----------------ALFS MNSVSL------------------------------------------------------ ------NGLLKSKFLGILTRQDREEFVELFLA------NG-------------------- --------------------FQLHKFLTPSKLSRLFRMIHD------------------- -----------------DEFFHAVCWETVLSK-SPVDR---QSKFFI---ETDLNWLLEF GT---------------------GLQNLVKINELHLNASD--------------FIEDSL V----------------------------------------------------------- ----------AERKALTLL--------------------------------TM------- -----WAVVQ----------------------------NRYEL----------------- ----------------------------------------VEILWKYCDHP--------- -----IHLALIISMFFDRLSWHV-YDT----------------NLKFELEQRSKTFAKYA YDV---LDRCY-QENI-----------------------------------SLAYNVLRE -------------------------------SIKDFNYMTAVDIAAN-----ARLKQFLA HPCCQKWLANTFQGKIRIREITWGFF---------------------------------- -------TVPVSIKILLCSLLVFPMYI----------WVRF-KNDKPKDD---------- ---DE-------------------------EFSDDDDEEEELDDVYENNANKD-GTYEMK QMSY-ANEAF-VNDGET------------------SKPSNMNQNITS------DRKKKRE VFVQK------------------------QPPL--------------------------- ----WKMIVMMWSAPISKFY-------TS-------------LFFYVIFLMVISL----- -----AALY--------------------------------------------PN----- ------------------------------------------------------------ -----------------------------------------------CGNIILDSIV-CS WSLLIAISYIRHVYI--------------------------------------------- ------------------------------LFIRY---SSVVTLYTKIIEILLILTFTGF FSTTRVL--------------RIYFYPIYWQKIMI------------------------- ---ALAVLYFYYRLISVYLPISPTLGPFLYRFRLMITVDFVNYMRITTVILIANSIAIRS LQYPYEELTIDS---------------------------------------I-----KSV FHQGIVSLFTGPPSG-----------------------------KILVTNDPKKQ-SEYC PNSFRSFD----NSSI----------IIDYQDN---------------QDT--------- -FIIYVFVFQFFIILKLILGPLLFSIFAVTASKWVSEIDS------------IW------ ---KFQRYQLVIDFANR----LSIPEPF-------------------------------- ----------------------------------------------------SIVYYLYI LCYYIAYIL-------C-CCCYSRNW-------------CKL---------------FER I---------------------------------------------YQQH-C-------- -------------------------------LYWKL--LAGEYIVDQQRQL-SRINENDE -----------------------LNHRQWDCIRDITEE----------------IEYEKK LLR-------------------------EIKSKLFEMEKFI------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Galendromus_occidentalis_XP_018495285.2_TRPS ------------------------------------------------------------ --------MDMWNLS-----------------------DV-------------------- -------------HKGC----TYNPPTWSRPSY--------------YRMKSTSKL---- --------YRRLTSR--DRPAFSTQR--------SVDTADL-------GRISPRTRKR-- -------RSRKIDEED-------ELSEDVPM-------VALS-----------AVPPAPE ----------------LSVD-----LSSRY----------FINRANAHFYKLFAFETE-- -------------CRPFIVV-----------------------------R-------HDI -NADDVLTVMHSEWKFI--------------------VPRIALLLVSDVGPMTEW----- ----------NHPRKLDAFKKGIIRAANT------------------------------T HMW---------------------------------IFT--------------------- NGLNTG------------------------------------------------------ ----IAKEIGDAVAEELSRR----RAKKCHKHPARK-KQNKPPLTLVGLCR-------ED LLL----------GWERFANS----------------------------DSADVNIQIEA NKPEEQRFELNPDHTHYIIVRD----------------DTIHR-TGINQYTL-------- ---------------------------RFERVL--------------------------- ---AA--------LGSRKNAKD--DIDSNGH-AKAKRQPSAI-----------TMQLPLM AILVQGDTN--------------------------------------------------- SAKFVFDRLQKE------------------------------------------------ -------------LP---------------------------------------ILVFQG TGGLADLIAFVYD----------EVQRRGV-------NVWDAEFIEE-FVKPELSAMIC- ---TQQQM---------------------------------------------------- ---------YAEQ-MQARNAYRDRVLEIVRLAC--------------HRQQGAHLTIVYT RN------------------------QSCDLE-----KLDQ-----VLLKALFKS----- ------QRSEQ----TMWYSQLKKDLQLTIDWNSPKVALE----------------EVFQ KDSANK------------------------------------------------------ ------FQIDSGIFMEALLREDREEFVDIFLR------RQ-------------------- --------------------FQLSKFMSKGRLRLIYQKVLC------------------- -----------------EDFFFLVCWMGALGN-T-SYR---VSDDFL---EYDLNWLIEF CT---------------------GLPEYVNGEQLSMAAAG-------------MCTGDET Q----------------------------------------------------------- ----------AERRALVIL--------------------------------AL------- -----WAIFT----------------------------HRRKL----------------- ----------------------------------------TKILWKHSDQP--------- -----IHLALIISTAYARLADYA-RDA----------------ATRAELEDSAKEFSEIA TGV---LDLSWEVDAG-----------------------------------CRAYDILSE -------------------------------VSPDWGEKTAVELAAQ-----GKNMMFLA HPCCQKWITNLFMGRITVRDLSWGLI---------------------------------- -------TLPQSAKIQMCAFLILPMYV----------FIRF-KDDP-------HQMEYKP ----------------------------------EPDEDDDAIEFVDDAPSIK-ENSAQM ------HQ----TKARA-MSLFRKQRQK-----------------------D----RETD SF----------------------------PPI--------------------------- ----WTMIYLMWSAPITKFW-------TF-------------QIFYIIYLMLFSI----- -----AVLL--------------------------------------------PS----- ------------------------------------------------------------ -----------------------------------------------CGYQPLDLVV-CV WTFLIAIESCRRSYV--------------------------------------------- ------------------------------LYRQY---TR-IPLALRCFEILFMFALVGF YGWSRVLKK----------TYPLS---PYGAKVLQ------------------------- ---CIGLLYSYYRQIVIYLPISPTLGPLLYRIKYMVSQDFINFMRMALLVMISGGIAVQA TMYPDHPWNWNL---------------------------------------A-----RMT IYRAVFSLFLTPVTEL----------GDFKSPTCAK-------------LD-KEG-KDAC LAA----------GPY---------NVTDS-NH------------LCPLKG--------- -FWTYTFSIQYLILLKIILMTLLYALFSNTARRIEAASDN------------IW------ ---KFQRYQLVMDFKNR----LCLPPPL-------------------------------- ----------------------------------------------------NLISYGFA ILNLTLGRLFRALKNWC-C-CR---------------------------KHDPSLG-MLP LPV------------------------------------VPAGATAKDSD-F-------- -------------------------------EYWRQ--ISQDFWTAREEE-----EQDEK -----------------------KKKDEMERMQKVLDE----------------IDSNRQ VLK-------------------------NLRAEMRELHRLVRQSR--------------- -----------------------------------NYL---------AEVKHSAEAQTVV -D-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AGGPGTQDIVRQAHF---- --LSKSSP---------------------------------------------------- ---------------------------------------------YPATKVLRFPVPDK- ----------------YVPWEVMWLD-----------YDPIVFTKPCNC-FSS--ELQPF IDEDVLQLNSE--------------------------------------------DQQR- ------------------------------------------------------------ --PKYQWNG--------------VSV---S-------------PAGVTTDRKSWIL---- ----------EHSQTV-VYLLEPEGV-----PKNPYGRTGL----------------RGK GGLCR-------W-----GPNHFVLF----------------------------VISRWQ TSRVH------------------------L-----VGG--------KGLEVV-LMRATRG GHYS---------LPGDFVPGED-LYASLEKFFRSTG----ETNLEYPKHSGEIKK---- -------FFQSLVKTS-------------------------SSAAAT------------- PTSET----------------------APTPIEERVRAEI-VD-------RGYMDDPHNT D-------NCWKEV-ELWSVHYTPEANENLH----------------------------- -----GFFDKSL-----G------------------WHLVTEDLFPKIHSG--------- ---------QAAL--------------LS-KVVKHIQSNLLS------------------ ----- >Strigamia_maritima_SMAR010526_TRPS -------------------------------------------------------M---- -------GIGRWPWSRRDY--------------PVTTPDS-------------------- -------------VESW----AQERGATRRNSK-------------PHRRSTRSKL---- --------QNVFMS--------SISG--------SLGRSR-------------------- --------------------------DGTPVKRHS--IVANK-----------TYPADDV SVVEINELQNTSSIDNLS-------ILSHS----------QLPQGRIFFTNEFSYEDD-- ------------GGRPYCRI-----------------------------A-------SDT -TMDDIGQIMGHDWKLS--------------------LPTIVMVVISSIKENSNW----- ----------KNHKQWTNLQTGIIEAANT------------------------------T NMW---------------------------------IVT--------------------- HGADTG------------------------------------------------------ ----IPKMIGNIVHKEKERR----QAMKCYRHPKQI-GTMFPDLYLLGIIR-------SS LIQ-----------YDYLLEN----------------------------R-TKIEVLNQG -ETEGGKYELNPDHSHFVIIDD----------------PSNDN-VIATDFVV-------- ---------------------------NLEKYI--------------------------- -------------LQSN----DVPDFGEPGA-KTSTRIENTIND---NLTIG-ASEIPVI ALLIGGGYK--------------------------------------------------- STLMVLEQLKSE------------------------------------------------ -------------IP---------------------------------------VVVIKG SEGAANLLAFAYE----------EIKQKSR-------GDWDPDYVEH-FIKSELSKKIA- ---SSFPK---------------------------------------------------- ---------YRDN-NLARNKFRDSILECIRHS---------------HKEDRFFLTFLDI YS------------------------HKINLA-----ELNQ-----HILRALFKA----- ------TTRTTE-DYEKRVKHLHKDMYLTLDWNSPHIALS----------------EIFQ KKHFS------------------------------------------------------- ------YKVDKKIFQSALLRTNRESFISLFLD------QG-------------------- --------------------FQVHRYLNEKRFHQLFLKAES------------------- -----------------PEFFRTVCMEGMLGY-SFSVK---LGREFV---ANDFNWIIKH LT---------------------KLRNFVDIGALNMNHTSG-----------LLSAVDQK V----------------------------------------------------------- ----------AERKAQTLL--------------------------------AL------- -----WAVLM----------------------------NRPKL----------------- ----------------------------------------AKLFWERTDYP--------- -----IHLSLVIGLMYSKLVPYV-RET----------------HLIHEMEERSKEFANMA VCV---LDMSF-LQNN-----------------------------------CRAFDILSE -------------------------------QVSDWNFKTAVEIAAD-----ARNRAFIA HPCCQKWLTNLFFGDIRIRELKWGTV---------------------------------- -------TLPVWIKVVLSAFLIFPMYI----------WVHF-KTG--------------Q KR-SI-------------------------MGIFDDGDSEEGSDVDSDAESVS-QPALSR MC---SRE----ADGRQ-SIVHVKDKGP---EIEGDKLDQMSKRRAKTKTWDWNMLRTPV TFLQ-------------------YFQPRPQPPL--------------------------- ----WKKIYIMWNAPVTKFW-------TY-------------QIFYIMYLTLFSL----- -----AVLQ--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGNVYLDSAV-WI WTALILMENIRKAYI--------------------------------------------- ------------------------------QYRDY---SS-VPLLASFIEIILLILFLLL YMTVRIIPNTNLEVLVHI---PIS---SYSARVVL------------------------- ---CIGLLYVYYRFIWIYLPISPTLGPLLFRIKLMVTVDFVHFLRLTLLFIISGGIVIHS VIYPNYPMDNEL---------------------------------------L-----RRV FHRAWFTLFITPFTDE----------LEGHLDRCNKSET-----VFLS--S-KYD-TCTA L-------------------------TENHFDY------------TCPRTG--------- -FVPYLMVIQYLIILKLILVTLLTALYSNTAQRDVRDTDA------------IW------ ---KFQRYHLVLDFNTR----YRLPAPL-------------------------------- ----------------------------------------------------NAISFMIS IIER-VCAVFR-----C-QYCR----------------------KQRQVPHEEQQR-ILR L---------------------------------------------KQND-H-------- -------------------------------NYWRG--LAAEFSRQEKIK-----EEEKD -----------------------LPSKQMECMQTLMQD----------------IEHHSW MLR-------------------------QMQVRFTELEKIMLNSK--------------- -----------------------------------VSL---------EEIKHE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LGGEDAKVLETVIHQ---- --FSRQSP---------------------------------------------------- ---------------------------------------------YPGTRVKRFPLADR- ----------------YVPWEVQFSI-----------YDPVVYSKKRSD-FQP--SERDC VDEDMLQQRND--------------------------------------------RGGKY N----------------------------------------------------------- -APNLKWNF--------------AYT---S-------------GAGITTDRTTWITT--- ----------SSGEPL-IYKLDSSGL-----PMNPMGRTGL----------------RGR GCLYR-------W-----GPNHCIYL----------------------------VVTRWR TADEF------------------------LQSMAGEEQ--------RELEFISMVNRAAP NLLT---------LPGAFIMNYDTVYESIQNQFLSGS----KKKEKWNA--ESMQK---- -------YFA--------------------------------SHARA------------- PAGDFVDI------------------VGEDAEQLNFISSM-LM-------RGYMDDNQNT D-------NAWLEA-EVWHFHYTASLTDEIKMPV-------------------------- -----RPHPVEK-----G------------------YIKYKRQVKAK-PCS--------- ---------HYS-------------------------GGSTATRKSHL------------ --KYY >Strigamia_maritima_SMAR006477_TRPS ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MTKLSFDRNYW--------------HLNDDKLGF---- --------SKYTVE--------ST------------------------------------ --------------------------EHTPI----------------------SSPGTPE SYGSGNR---------------------------------IFPGGLLSFRTEY-FEPQ-- -------------TKPYICV-----------------------------G-------HNE -DISDVVNTLARIWKLS--------------------CPSIVIMIVSSISQPLRY----- ----------PTHGQWKSLQKGLIKAANT------------------------------T SMW---------------------------------IVT--------------------- NGVNSA------------------------------------------------------ ----VGKLVGDAVRLEELHR----QSQTCSWHPETSTIRLVPKLVLIGITS-------SN ILA-----------YENLLDG----------------------------KGTVVELPCEG FQSEDRKYELNPDHTHFIVVKD----------------GTIDN-SGAQSFAV-------- ---------------------------QLADYL--------------------------- -------------MHS--------DVSGPTE-NVSSPARH-------------RNEIPVV GLLVQGGFS--------------------------------------------------- SLKLALELLKRE------------------------------------------------ -------------IP---------------------------------------ILVLKE SGGSADFIAYAYE----------EIKENNR-------GDWDPQYVEV-FVNSEISRRIA- ---IEFPL---------------------------------------------------- ---------FREN-NLARNRYRDKVLECIRFS---------------EQNGQQFLTFLDI YS------------------------QSCSLA-----GMEK-----EILKALFKS----- ------QKRDRL-GENQRYDQLQKDLYLTIDWNSPQVALE----------------EVFR KDPTAR------------------------------------------------------ ------FKVDKAVFEDALVKQNREDFIDLFLD------QG-------------------- --------------------FQIHKFLTERRLWRLFEKADN------------------- -----------------PQFFRAVCWEEILGH-RFEAK---LGRDFV---HKELNWLIKS LT---------------------GIREFVPVQELTSNAMG-------------FYTTDPV V----------------------------------------------------------- ----------AERKALNSV--------------------------------II------- -----WAVLM----------------------------NRPKL----------------- ----------------------------------------VKVLWKRSDHP--------- -----LHLALLIGMIFSKLSLYVRTQQ----------------HLLKNLEQSSRDFQEMA LGV---LDLSF-QQNN-----------------------------------CRAMDALNA -------------------------------KMPDWEFQSAVEIAAT-----AKNQDFIG HPCCQKWLNDRFLGRIHIQEVQRGIF---------------------------------- -------SVPSSLKIILSAFLIFPIYL----------WINF-QTG--------------T QV-SI-------------------------AGAEEDSDVDEEHDIMSVAQLVN-ST---R ------------PD-----LLVHENRAPVQFQHRGRHTENINSKILR------GVIRPTT SWIMKPKAWHKGPKWIKEKPSVWYYRKGPQPPL--------------------------- ----HKKIYFLWSAPITKFW-------TF-------------QLTYILYLVFFSY----- -----IVLL--------------------------------------------PS----- ------------------------------------------------------------ -----------------------------------------------CGNKNLDLIL-WC WTLTILVEIVRRSYI--------------------------------------------- ------------------------------QYTQY---RS-MTVFNKVIEIILVLVFLIL YMFLRIF---KLEILKELFQEPQDLKVAYAARVVL------------------------- ---CVGLLYFYMRLMVIYFPISPTLGPLLYRMRLMITIDFYNFIRLAMLILISSAIVIHA IMFPDYPMGKEL---------------------------------------V-----RRA FHRTWFSMFLTFASD-----------LEVD-PSCDTITT-----EYYHGLK-KKD-PEAC L-------------------------MGDSKDP------------DCATTG--------- -FWPYIMNIQYMINMKLILLTLLYAMFSNTQMEQAADADA------------IW------ ---KYQRYRLVFDFDTR----LRLPPPL-------------------------------- ----------------------------------------------------TIFSYILM LLH----CVYK-----C-CFCKG----------------CQK--ESHETHHDDGTE-HRK F---------------------------------------------KASD-F-------- -------------------------------NYWRI--MATEYFRQLEET-----EKKKL -----------------------IEKEQLEKLNGLCYN----------------AEVQMS ALK-------------------------KLKGSMAELEIIMQNCR--------------- -----------------------------------IAL---------EDIKHE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------FVKTDEKMIANMTNL---- --LSRQSP---------------------------------------------------- ---------------------------------------------YFSTKVQRYSFSDK- ----------------YVPWEVLFST-----------YDPVVYSKPRED-YPL--NIRDF VDEDVLSLKEK--------------------------------------------QGEHY K----------------------------------------------------------- -VPEMKWNI--------------VYT---S-------------GAGITTDRTSWLQN--- ----------EKGEVV-IYKLDSTGL-----PINPLGRTGL----------------RGR GALLR-------W-----GPNHAIYL----------------------------AITRFR TEGQ-------------------------LQSVY-TEP--------KTVEFV--ISPHDG SQWI---------LPGGFMLHHTNPYEVIREKFLPTA----QDIIIWTGY-DDMKQ---- -------AFQDFCGT--------------------------RDFTQE------------- PLSEF--------------------------EDPNFSCVL-LQ-------RGYLDDALNT D-------NAWIEA-EIWHIHFKTSCNLDGK----------------------------- -------HLRGM-----K------------------WRTSASQIKNKMPMS--------- ---------HANI--------------LD-KIVHKLEGTS-------------------- ----- >Branchiostoma:floridae_Florida:lancelet_XP:035685384.1_Chr8_LOC118421987_TRPM1_Cephalochordata_TRPS ------------------------------------------------------------ ---------------------------MVGRFPQVSSDENSS------------------ ---------------------DDEGLKVTEGAG--------------------------- -----------VVEERLQVPPSSYQRPGG----------------LSRRRSRFRQKRRFP RFWRGVNVSKYVTCCG----SDSEDSEVDDLQEELA-----------------SYLAEQG NQGSTTSLQFQLPQGSYME-------------------------GVL------------- ------PLRYGEESRPYLLL-----------------------------NK------VNC PSMEVISEHLHRTWRIE--------------------RPKVILSLYCEPEHFSLW----- ----------KRRKIYDALQTGLIKLAST------------------------------T NMW---------------------------------LIT--------------------- NGANLG------------------------------------------------------ ----VGKLVGDAMKREKARR----------EYIVVKEEEDQPMLRAVGISPFCAV---AH MLPR----------WRTIQDG--------------------------------------- ---VRDQWELNPDHTHFIVVDD----------------GTDDNWNAEHELRL-------- ---------------------------QLQHHY--------------------------- --------------------------------RSPRQTYNVLPG-----TTSRKKANPVV CVLVQGGPA--------------------------------------------------- SIQYVQGCVQQE------------------------------------------------ -------------TP---------------------------------------VLLLKG SGKAADLLAFAYE----------EIKERPP----------QEDWMQ--YLRAELSRRIF- ---KTFPK---------------------------------------------------- --------LSQEE----VQELKESIIDCVNDA---------------IKEDQVFLSILEV QG------------------------FHDDLE-----NLDK-----YILTAILKA----- ------QADVSD------DNVVQSDLQLTLQWNRPDLALS----------------EIFQ SPYFPDN----------------------------------------------------- ------IKIPPRLFEKALLKKDREEFVELFLS------QG-------------------- --------------------FDPGDFLTRSRYRRLFEKADD------------------- -----------------REFIKGVF--GAMGY-NLPDF-GVLPDNFL----TTLKKVICQ IAEVEVY----------------------------------------------FFCHEDP T----------------------------------------------------------- -----KERPNTERAALMCL-------------------SSFQKKTKVMMDLLL------- -----WAILV----------------------------NKQRL----------------- ----------------------------------------VRIIWEQTEDP--------- -----IPLALYIRRVYMSLTKFV-EDT----------------TLRKEMETLVVEYEDLA VGV---LDTGY-KEST-----------------------------------KKATDILNE -------------------------------MIPDLKVKTAIEVAYD-----SKCKKFIA HPCCRKWVKRKYMGGISVKKTMA------------------------------------- ------SFLPSWLKILLSAFLIFPMFF----------FIDF------------------- ----------------RFL-----------KPTVEEQKAQRRKELLRGSQQSGIQNSVYQ NPIYQHVE----------RQVEEGCEASCRYCTGYHCNCTLNTCLLNF------------ ------------------------------------------------------------ ----FRRVKALWTAPITKYW-------AH-------------VLCYMIFLFLLSL----- -----SGLL--------------------------------------------PG----- ------------------------------------------------------------ -----------------------------------------------CGNILLDMAI-SL WMTTSIVELIRTIYR--------------------------------------------- ------------------------------DNEMF-KSSSGWHNVWGYTETVLIVLFWVA HFVVKVVGT------------RVGFVHPKDAKLLL------------------------- ---AIMVFFFFLRLLYVFAPNSLSLGPRLVMLRKMIQIDLVVFFRLLVVFMCIHGVVSQI LLQPWHQLDSSV---------------------------------------V-----EML VWRPWLHVWLTPYSY-----------LEGN---CDSLVVVPP------------------ -----------PDQPP-------------------SWYAPNVTMPTCPAET---SDACEG HWFLYMSLSFYLICVRFGLLTVLFAMFNKTYQRVHGESRE------------IW------ ---MYQRYKLIIDLDRR----DSLPPPL-------------------------------- ----------------------------------------------------VIFHYIYM LGRYL-------------CWCWK----------------CRVVTKIKVAYGEKTYSSQDM VDGGLD---------------------------------VPDGEELDEDR-F-------- -------------------------------SFWKS--CAHSFNSSQRKQA-AQ-ESRQM --------------------------TQTEVYEQVSDD----------------LSRLDV RVRRRHD---------------------RLHDRVVKVEKMMQESM--------------- -----------------------------------LTL---------ETIKHLLLTKESR -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VEGVSTTQTGAILHI---- --AARQSP---------------------------------------------------- ---------------------------------------------YFGTKKKRFPVFDK- ----------------YVPWKVLFVE-----------YDPPRYTAPMEY-FSE--WFRQF ADE--------------------------------------------------------- -------------------------------------------------------VDPST QKPAPVWNE--------------VVGYKMQIWREGEGGEREQLEEVMEVDRRSWIEDK-- ----------DKGVGI-RYNITSEGV-----PQNPMGRTGL----------------RGK GALFR-------W-----GPNHSMLA----------------------------ICTRWK RSVDPAT------------------GDEQEEYLLVEGK--------RVLEFL-SYKEPDF EEWA---------IPGAMTAGLESKYSVLHRAFCTKALGKQLAVVNRHMDESKVKQ---- -------LFEAYTVD----------------------------------------ERDCT PSERDDPI-------------------------ETFSAAM-IY-------RGYVDDPRNT D-------SAWVET-EAWHFHYESG----------------------------------- ----ENFLEEEMVAAGSR------------------WQEVSRHV--KLFAS--------- ---------HASV--------------IQ-EAAARL------------------------ -NAYF >Hypsibius:dujardini_Water:bear_OQV20961.1_BV898:05036__TRPM1_tardigrada_Ced:11_TRPS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MTRAGVLHFTQRTDS---------------------------------- -----------------ITDSENGLLAALPL-------------------------KLTD KKNETQEDLRASP-----------LILSK------------------------------- -------------KKPFLLF-----------------------------D-------AKQ AGPEIALELTSRYFS-H--------------------PPDVLVSFVSGTDLFHTW----- ----------KRDDFRSALQAGIVKLLSA------------------------------L DLM---------------------------------IID--------------------- DGLNYG------------------------------------------------------ ----LTRLLASAIRSEEEYR----------SHTSGQ-SAKKPFINYLGIVPLQKVANSDK FRSE----------RGASDDS------SIEV------------------------VPRRP GAALDDGFDLNPHHSHYILLDK----------------SPEDV----NFLRV-------- ---------------------------DVEKQL--------------------------- ---QGQ-----LALQQAQ--------------MVADSTEDPS-------TTS-MSFVPHV IILFQGGLE--------------------------------------------------- ELDRVQAYLELH------------------------------------------------ -------------TP---------------------------------------VLILNG CGGIADVIVGAMK-----------SSSEPD-------EK---------RLRGALSSRLV- ---RAFPT---------------------------------------------------- --------LQRNE-RL-RQEYTNKLMHVIRQAAPP-----------S-----KLCQIIDC T-------------------------RLDTFE-----SLDK-----PLLQAVIIS----- ------SAARH----ANWDQMVR-NFMLCLKCNRSDICAAFLVNSPPWCDIP-------- ------------------------------------------------------------ ------SKIPYPGMVSALIYPGREAFVDMLLQ------QR-------------------- --------------------FPVRFLTSYMDLVALFRKAVG------------------- -----------------KELFLGLVWDDILGH-NQSDP---IREEFV---LIELNPLIYK LT---------------------GVRNYLDFYELSRVALT-------------------- -------------------------------------RDDTL------------------ ----------------------------V---------SPAVSDANGLNALIV------- -----FAVLL----------------------------NRAKL----------------- ----------------------------------------VKVLLKYAMDP--------- -----IPTIVFVETMYRGMYRHT-VNT----------------ELRTGLKRQADEFGTMA TEI---LDAGI-RESP-----------------------------------QRAKTFFQR -------------------------------TIPAYNGKTTLEMAFD-----ARNRTFIS NPLVQNWLDSFGNGFIRVKGGCE------------------------------------- -----------ELKMVLSAYLLFPMYI----------WLSF------------------- ----P-------------------------KLVQEKSAAVAESGFTYEPQSKQ-QALGLL ------------------ESIKSQKNLS------------------GI------------ -----------------------AKYTERYPPF--------------------------- ----FSMVHAVWSAPIVKYW-------TW-------------FIIYILFLIVIGT----- -----DMMM--------------------------------------------PA----- ------------------------------------------------------------ -----------------------------------------------CTNWGLDIAV-VI LTLLIWLELVLRTVM----DI----------------------LY--------------- --------------------------------RRR------MDVLLRATDIIFQTVFNVL FIIYRVATY-N------------RYEHPFAGRVIL------------------------- ---AFGVMYYYYSVWQMFFVFSRQLGPLVRICMIMFKQDLPKWLIMMLPFFISVTVVWQA IITPDYPFTGED---------------------------------------W-----RRA IYRSTFTFFGAFYTE-----------LE-----------------------Y----SESC EANTKINWNN-FSQPLAADPLDRCWL-GDYSDH------------KCNTVS--------- -FWAYVFVGNYYFFLKLGMTIILVVFYIFRQTVEMPKANL------------IW------ ---RYYRFETLFDYYWR----SNLPFPL-------------------------------- ----------------------------------------------------NIIGNIHL IVMYF---------------------VTG--------------------------RKEMQ VKLD------------------------------------PELVDLKQDT-F-------- -------------------------------IYWKS--VAADYFAKKDRE-----ESSRA -----------------------IPIQQAASLGAIKGG----------------LQSIIA --RFG-----------------------ELGKKLSEVDESARDNR--------------- -----------------------------------QRLR--------QTTDAVIRQISSG -A-S------------HDLESVAAPH---------------------------------- -----------------P------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------HT---- --RSRDSP---------------------------------------------------- ---------------------------------------------YIGTAIRRLHVDDD- ----------------KVDWETVLEH-----------YHPEPYSRALED-FSV--EEQEF VDHERDNRRAL------------------------------------------------- -------------------------EFRM--------------------------SASAA SMQSTDWNAIE-------------------------------YNDEDAIYRKTWIVD--- ----------ENGDPL-MYRLDANGL-----PMNPNGRTGL----------------RGR GSHCR-------Y-----GPNHRIIL---------------------------AITTTAN KKSRF------------------------------------------------IIQLSPG NSGT---------LPNVPLCHYDSEYS-VAAILLDSIFNEGDTSEDSDFDPSTIKTESEL SEIVPMLYGKQWRKDP-------------------------AN------------AENTQ PKSAPIRQ---------------------------------LY-------RGYLDTPLNT D-------NAWMEA-LVLHVAVP------------------------------------- -----SVRLEATS--VYR------------------WKTYSP------------------ --------AESGL--------------LD-FDAVIMRSLNL------------------- ----- >Priapulus:caudatus_Priapulus:caudatus_XP:014670278.1_NW:014577579.1_LOC106811238_TRPM1_Priapulida_TRPM3:like_TRPS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ME---MEDRFSSNP---------------------------------- -------------------------TGGNPVSYVS------------------------- ----------------FSSD------------------------------EDIAIDSE-- -------------PKPYLRL-----------------------------P-------YNA -SSNDWFNCLRYAWNLK--------------------PPSIILSIFSTTNTRKRW----- ----------HDQHQKERFQMGLVKAANT------------------------------T PVW---------------------------------ILT--------------------- NGMDRG------------------------------------------------------ ----IANLIGDAIRQEKLKR-ETSYMHNVYVQEGIRRHQRLPKLIVIGIAN-------TT LID-----------YEDALAGDNSK---------------------YPQRGPTVMVKNGD KRLVGDKGELNPYHTHFLLVDD----------------TTPDK-SGMTIFQV-------- ---------------------------RVHRRM--------------------------- ---SCPGG-YSRQNSRPSESEQGAGRSDDVLLNMETEEENA--------RCM-TAEVPVI GIVMQGDAA--------------------------------------------------- VVDLALVHLKMQ------------------------------------------------ -------------LP---------------------------------------VIVMKG TGMLADLLAFAFT----------ELTERS-----------DNEYLQS-YIKPELSRRIL- ---HTFLE---------------------------------------------------- --------QCANN-DIAMRQIRDRIIECVKVA---------------KKGGRSCMTVIDI NS------------------------ASCDLA-----DLPK-----YILYALFKS----- ------QYRLS----RLEPEQLHTNLRLTLDWNCPDMAVS----------------HIFQ KLGGGK------------------------------------------------------ ------IKINKELFELALLRKDREDFIELFLD------HG-------------------- --------------------FKIHKYLSHRKLELLFEKGED------------------- -----------------QGFFLNVCCGSILGYHVESLKDS----------QATINYMLNC LT---------------------GLNYKVEYHELSMNVSG-------------VETLEQS AD---------------------------------------------------------- ---------SAEMKARTVL--------------------------------IM------- -----WAVLF----------------------------NRPKL----------------- ----------------------------------------AKVLWKRSEEP--------- -----LVLALVLHRMYNMYAKFY-VEP----------------HLVSEMKAIAAGFQDLA VGI---LDISW-IESP-----------------------------------HRTLRMLSA -------------------------------ERKYWENYSVIQVAYI-----SVARKFIG HPCCQSWLTGIYMGEIEVKNLKWGPF---------------------------------- -------ALPQPLKVWTSAFLILPMYV----------WINF-NTRESK-----ETRRAVQ QT-DL-------------------------DEADGEDEGEYTAEIEDD------------ ------------KTGPS---------------------DRLNNLEID----GINMSHTLF HFMDK------------------LKRSEQRLPL--------------------------- ----WRKVYKLWSAPVTKFW-------TF-------------QTFYVFYLLLFSY----- -----AVIL--------------------------------------------PT----- ------------------------------------------------------------ -----------------------------------------------CGDLYIDVAV-WG WTLTILMEIIRRTYL--------------------------------------------- ------------------------------QYKLY---RI-LPLFLKSVEIVCVIVFLIA FLLLRILSD------------EIGFHYPFSAKVVM------------------------- ---CLGLMYFYMRMIVTYLPISQTLGPMLVRIRRMVYVDFLDFMRVFLIFMAGGAVVMHA VIYPDFPINEEL---------------------------------------F-----RSA FHRAWFSLFITPVSE-----------LEGR-QQCTRTE--------------SYG-PDRC VQGL----------------------FTDH---------------TCPHTG--------- -VMSYAVVITYLIICKMILVTLLFALFSSTNQKIQPIADE------------IW------ ---LYQRYSLVIDFSNR----LRLPPPF-------------------------------- ----------------------------------------------------TVISYVLM TLEFIYRKL-------C-CTCRAADIPHG----------------------------MQE L------------------------------------------QRREALS-Y-------- -------------------------------SYWKM--CAHRCWLKKDEA------GSKM -----------------------VASTNKDASNAVLEEL---------------LEMHKT SLR-------------------------RVKDRLVEIERAVFNGR--------------- -----------------------------------MHV---------ENIHHLLEQKG-V -A-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IVG----KRGFDVHV---- --LARQSP---------------------------------------------------- ---------------------------------------------YPFTDLPKYPVLDK- ----------------YVPWTSEYSL-----------YDPVIFSQPASA-YSD--ELRSL VDPDIIEEQEV--------------------------------------------KHNRA VEVDAIVEQENSDSD-----------------------------------SDSCSLVVAD SARSFAWNA--------------IESVSVN-------------GRRVTVDRQSWIVS--- ----------ADGSRC-VYEVDVMGL-----PRNPWGRTGV----------------RGR GVLCF-------W-----GPNHRVDM----------------------------VITRFK RREGT------------------------RDFVYMDGK--------KMLMCL-LIRE--G GNLC---------LPGGYVHGLESRYTVIMRSFMEKVLGE-GVDSSRDDSAQDMIQ---- -------FFNRYASA--------------------------------------------- --------------------------------STRVRARH-LY-------TGYLDAVRNT D-------NAWIES-ECWHFHYDHADVIDSKLP--------------------------- ------KESSTV-----E------------------WKPVSPDM--QLPAS--------- ---------LVAL--------------IQ-QAHDTLDSNN-------------------- ----- >Drosophila:melanogaster_fruit:fly_NP:609802.1_Chr2L_Arthropoda_TRPgamma ------------------------------------------------------------ ---------------------------------MMEEE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------NTIRPHQEIR------------------------------------------ ----------------QLTL-----------------------------EE--------- -----------KKF---------------------------------------------- ---------------LLAVERGDMAGTRR------------------------------- ------------------------------------MLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KAQDTEYINV-------- ---------------------------NCVDPL--------------------------- ---GRT----ALLMAID------------------------------------NENLEMV ELLINYN----------------------------------------------------- ------------------------------------------------------------ --------------------VDTKD-----------------------------ALLHSI SEEFVEAVEVLLDHE--------NVTFHS------------------------------- ------------------------------------------------------------ -----EGNHSWE------------------------------------------------ -------------------------------------SASEDTSTF-------------- ------TPDIT-------------PLILAAH----------------------------- ------------------------------------------------------------ --------------------RDNYEIIKILLD------RGAVLPMPH------------- -----------------DVRCGCDECVQSRQEDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYRAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSKDP--------- -----ILTAFELSWELRRLSFLE-HEFK------------------NEYQELRKQCQDFA TAL---LDHTR-TSHE-------------------------------------LEILLNH -DP-----------TGPVYE----H--------GERMHLNRLKLAIK-----LRQKKFVA HSNVQQLLASIWYEGLPGFRRKN------------------------------------- --------MALQAVDIIRIGIMFPIFSL-------AYILAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----YSSIGQTMRKPFIKFI-------CH-------------SASYFTFLFLLML----- ----ASQRIETF---------------------------IGGWFFADS--SGMLNTM--- ------------------------------------------------------------ ---------------------------------------EELPTKRGAKPTFIEWLI-LA WVSGLIWSEVKQLWD--------------------------------------------- -----------------------------VGLQEY------LNDMWNVIDFVTNSLYVAT VAL-RVVSFFQVQKEM----------IYNSHATDL----------PRERWDAWDPMLISE GLFSAANIFSSLKLVYIF-SVNPHLGPLQVSLSRMV-MDIMKFFFLYVLVLFAFGSGLNQ LLWYYADLEKKRCPEVSPMSALLN--MNGTNDPNA--CIVWR-------R-FSN--LFET TQTLFWAVFGL---------------IDLD--------------------SFELDGIK-- ---------------------------------------------------------IFT RFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADV------------EW------ ---KFARSKLWISYFEE---GGTCPPPF----------NIIPT----------------- ---------------------------------------------------PKSIWYAIK WMRRVF---------------------------------CSGS----------SAARREH LKTI---------------------------------------RRKAQQA---------- ---------------------------SDRDFKYQQ--IMRN------------------ ----------------LVRRYVTVEQRKAES-QGVTEDD---------------VN---- ----------------------------EIKQDISAFRCELVEIL--------------- ----------------------------------KNS---------------GMDTNVTA -G-QGG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GGG GKKNRQKERR------------------------------------------LMKGFNIA PP-------------------------------------------GSTGSLAP------- ----------------------------------------------VAE-FST--SLDNY DNQHEILSSTLST------------------------LFTPNFMH----------KRQQS QAGSGG------------------------------------------------------ -------GGSESPTTP-----------------------------------TAPQGTQGA --------AMTASSQV--------------TKYNKSALKPY----------------NKR IAGHKK-----RW-------GTLIEAAK-----------------------VGNVSKMLG RSKSEDSVC-----------NS-----------------SHTSTPVHG-QMRVTYAQNSP QQEYG--------YHGETSSTTIS------------------TPTPTISVVSNSPAAHAG ---VGSHFFHTT----------------SGLTAIAAL-----KRKRKKF----SSSKNIC PVTESVAAAN---------------------------------------------AAEIL N-----------DK-TLKRVSSYPA--------------AEA--GV-QHNPAQLV-KP-- -----------------R--------------------RHEQTQ-SQ------HDS---- ----VETNSTFT--LS-----I--DP-----SNTSVNSREPLISTSC----VSTTGAI-- --G-- >Drosophila:mauritiana_fruit:fly_XP:033173512.1_Chr2L_Arthropoda_TRPgamma ------------------------------------------------------------ ---------------------------------MMEEE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------NTIRPHQEIR------------------------------------------ ----------------QLTL-----------------------------EE--------- -----------KKF---------------------------------------------- ---------------LLAVERGDMAGTRR------------------------------- ------------------------------------MLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KAQDTEYINV-------- ---------------------------NCVDPL--------------------------- ---GRT----ALLMAID------------------------------------NENLEMV ELLINYN----------------------------------------------------- ------------------------------------------------------------ --------------------VDTKD-----------------------------ALLHSI SEEFVEAVEVLLDHE--------NVTFHS------------------------------- ------------------------------------------------------------ -----EGNHSWE------------------------------------------------ -------------------------------------SASEDTSTF-------------- ------TPDIT-------------PLILAAH----------------------------- ------------------------------------------------------------ --------------------RDNYEIIKILLD------RGAVLPMPH------------- -----------------DVRCGCDECVQSRQEDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYRAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSKDP--------- -----ILTAFELSWELRRLSFLE-HEFK------------------NEYQELRKQCQDFA TAL---LDHTR-TSHE-------------------------------------LEILLNH -DP-----------TGPVYE----H--------GERMHLNRLKLAIK-----LRQKKFVA HSNVQQLLASIWYEGLPGFRRKN------------------------------------- --------MALQAVDIIRIGIMFPIFSL-------AYILAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----YSSIGQTMRKPFIKFI-------CH-------------SASYFTFLFLLML----- ----ASQRIETF---------------------------IGGWFFADS--SGMLNTM--- ------------------------------------------------------------ ---------------------------------------EELPTKRGAKPTFIEWLI-LA WVSGLIWSEVKQLWD--------------------------------------------- -----------------------------VGLQEY------LNDMWNVIDFVTNSLYVAT VAL-RVVSFFQVQKEM----------IYNSHATDL----------PRERWDAWDPMLISE GLFSAANIFSSLKLVYIF-SVNPHLGPLQVSLSRMV-MDIMKFFFLYVLVLFAFGSGLNQ LLWYYADLEKKRCPEVSPMSALLN--MNGTNDPNA--CIVWR-------R-FSN--LFET TQTLFWAVFGL---------------IDLD--------------------SFELDGIK-- ---------------------------------------------------------IFT RFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADV------------EW------ ---KFARSKLWISYFEE---GGTCPPPF----------NIIPT----------------- ---------------------------------------------------PKSIWYAIK WMRRVF---------------------------------CSGS----------SAARREH LKTI---------------------------------------RRKAQQA---------- ---------------------------SDRDFKYQQ--IMRN------------------ ----------------LVRRYVTVEQRKAES-QGVTEDD---------------VN---- ----------------------------EIKQDISAFRCELVEIL--------------- ----------------------------------KNS---------------GMDTNVTA -G-QGG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GGG GKKNRQKERR------------------------------------------LMKGFNIA PP-------------------------------------------GSTGSLAP------- ----------------------------------------------VAE-FST--SLDNY DNQHEILSSTLST------------------------LFTPNFMH----------KRQQS QAGSGG------------------------------------------------------ -------GGSESPTTP-----------------------------------TAPQGTQGA --------AMTASSQV--------------TKYNKSALKPY----------------NKR IAGHKK-----RW-------GTLIEAAK-----------------------VGNVSKMLG RSKSEDSVC-----------NS-----------------SHTSTPVHG-QMRVTYAQNSP QQGYG--------YHGETSSTTTS------------------TPTPTISVVSNSPAAHAG ---VGSHFFHTT----------------SGLTAIAAL-----KRKRKKF----SSSKNIC PVTESVAAAN---------------------------------------------AAEIL N-----------DK-TLKRVSSYPA--------------AEA--GV-QHNPAQLV-KP-- -----------------R--------------------RHEQTQ-SQ------HDS---- ----VETNSTFT--LS-----I--DP-----SNTSVNSREPLISTSC----VSTTGAI-- --G-- >Teleopsis:dalmanni_Cyrtodiopsis:dalmanii_XP:037959984.1_ChrX_Arthropoda_TRPgamma ------------------------------------------------------------ ---------------------------------MMEEE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------NIIRPHQEIR------------------------------------------ ----------------QLTL-----------------------------EE--------- -----------KKF---------------------------------------------- ---------------LLAVERGDMAGTRR------------------------------- ------------------------------------MLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KAQDTDYINV-------- ---------------------------NCVDPL--------------------------- ---GRT----ALLMAID------------------------------------NENLEMV ELLINYN----------------------------------------------------- ------------------------------------------------------------ --------------------VDTKD-----------------------------ALLHSI SEEFVEAVEVLLDHE--------NITFQS------------------------------- ------------------------------------------------------------ -----EGNHCWE------------------------------------------------ -------------------------------------STAEETSTF-------------- ------TPDIT-------------PLILAAH----------------------------- ------------------------------------------------------------ --------------------RDNYEIIKILLD------RGAVLPMPH------------- -----------------DVRCGCDECVQSRQEDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYRAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSKDP--------- -----ILTAFELSWELRRLSFLE-HEFK------------------NEYQELRKQCQDFA TAL---LDHTR-TSHE-------------------------------------LEILLNH -DP-----------TGPVYE----H--------GERMHLNRLKLAIK-----LRQKKFVA HSNVQQLLASIWYEGLPGFRRKN------------------------------------- --------MALQAVDIIRIGIMFPIFSL-------AYILAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----YSSIGQTMRKPFIKFI-------CH-------------SASYFTFLFLLML----- ----ASQRIETF---------------------------IGGWFWNDSH-SNLLSQV--- ------------------------------------------------------------ ---------------------------------------EELPTKRGAKPTFIEWLI-LA WVSGLIWSEVKQLWD--------------------------------------------- -----------------------------VGLQEY------LNDMWNVIDFVTNSLYVAT VAL-RVVSFFQVQKEM----------ITNPYATDL----------PRERWDTWDPMLISE GLFSAANIFSSLKLVYIF-SVNPHLGPLQVSLSRMV-MDIMKFFFLYVLVLFAFGSGLNQ LLWYYADLEKKRCPEVSPTNVLLS--LNGTTDPNA--CIVWR-------R-FSN--LFET TQTLFWAVFGL---------------IDLD--------------------SFELDGIK-- ---------------------------------------------------------IFT RFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADV------------EW------ ---KFARSKLWISYFEE---GGTCPPPF----------NIIPT----------------- ---------------------------------------------------PKSIWYAFK WVRRVF---------------------------------CSGS----------SAARREH LKTI---------------------------------------RRKAQQA---------- ---------------------------SDRDFKYQQ--IMRN------------------ ----------------LVRRYVTVEQRKAES-QGVTEDD---------------VN---- ----------------------------EIKQDISAFRCELVEIL--------------- ----------------------------------KNS---------------GMDTNVTA -G-QGG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GGG GKKNRQKERR------------------------------------------LMKGFNIA PP-------------------------------------------GSTGSLAP------- ----------------------------------------------VAE-FST--SLDNY DNQNEILTSTLSN------------------------LFTPNFMH----------KKQTN CCSNSNCN---------------------------------------------------- -----DLNEKESPPLT-----------------------------------TAVQTTN-- -------------------------------KYNKSTLKPY----------------NKR IAGHKK-----RW-------GTLIDAA--------------------------NVSKMLG RSKSEDSVC-----------NS-----------------SNNSSPVHG-QVRVTYSQNSN QH-----------YHGDLNTAEQT------------------ANSNSIANAHNLKEHSGG ---VSTHFFHTT----------------TGLTAIAAL-----KKKRKKF----SSSKNIC PVTESISTAN---------------------------------------------GTDTL N-----------DK-FLKRVSSYPASN------------ADS--GV-QNKDATIIAKP-- -----------------R--------------------RHEQTQ-SQ------HDS---- ----VETSTEFT--LSSEIHHL--DP-----SNTSVNSREPLISSSY----ASTS-II-- --S-- >Centruroides:sculpturatus_bark:scorpion_XP:023217963.1_Arthropoda_TRPgamma ------------------------------------------------------------ ----------------------------------MDEEAGEC------------------ ------------------------------------------------------------ ------------------------------------------------DPEEVKCHVN-- ------------------------------------------------------------ ----HAPHPPPKQEKTERK----------------------------------------- --------------EGQLLF-----------------------------EE--------- -----------KKF---------------------------------------------- ---------------LLSVERGDLASVRR------------------------------- ------------------------------------YLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SAKEKGQINI-------- ---------------------------NCVDPL--------------------------- ---ARS----ALLMAID------------------------------------NENLEMV ELLIKYG----------------------------------------------------- ------------------------------------------------------------ --------------------VETKD-----------------------------ALLHAI SEEYVEAVEVLLEHE--------EAHHAP------------------------------- ------------------------------------------------------------ -----GEPHSWE------------------------------------------------ -------------------------------------AIDQDTATF-------------- ------TPDVT-------------PLILAAH----------------------------- ------------------------------------------------------------ --------------------RDNYEILKILLD------RGWDIPLPH------------- -----------------EVRCGCNECVRSRSEDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINSFRAL-------------------------------------------- --------------------------------------ASPSL----------------- -------------------------------------------IALSSKDP--------- -----IFTAFELSWELRRLSFME-HEFK------------------NEYQELRRRCQNFA TAL---LDHTR-SSYE-------------------------------------LEVLLNH -DT-----------TGPAFE----H--------GDRMHLNRLKLAIK-----YKQKKFCA HPNVQQLLASIWYEGLPGFRRKN------------------------------------- --------VVFQTLEICRIGILFPVYST-------CYIVAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----HSSLGRTMRKPFIKFI-------CH-------------SASYVTFLLLLIL----- ----ASQRIETV---------------------------VVEWFGTEEM-KARVKG---- ------------------------------------------------------------ ----------------------------------------DVTTKRGATPSIVELMI-LA WVMGLIWSEIKQLWE--------------------------------------------- -----------------------------LGLTEY------VNDMWNIIDFITNSLYVAT VAL-RIVAYFQVQKEI----------YQNRGTAYL----------PREKWDAWDPMLIAE GLFAAANIFSSLKLVYIF-SVNPHLGPLQISLGRMV-IDIVKFFFVYTLVLFAFACGMNQ LLWYYAEMEKKVCI---SGRNLND----TKTEPGA--CLTWR-------R-FAN--LFES SQTLFWASFGL---------------IDLD--------------------NFELSGIQ-- ---------------------------------------------------------SYT RFWGMLMFGSYCVINVVVLLNLLIAMMNHSYQMISEQTDI------------EW------ ---KFARSKLWMSYFED---GGTVPPPF----------NIIPT----------------- ---------------------------------------------------VKSCYYLMR WISKKL---------------------------------CGQS----------RTAKKEH LKTI---------------------------------------RRKAKQA---------- ---------------------------SARDQRYQT--IMRN------------------ ----------------LVRRYITKEQRKADN-QGVTEDD---------------VN---- ----------------------------EIKQDISSFRYELIEIL--------------- ----------------------------------KNS---------------GFNTSSAS -D-PSQ------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GTG GKKNRQKERR------------------------------------------LMKGFNIG L---------------------------------------------VEGSVQT------- ----------------------------------------------ATE-SNI--PVELA E----------------------------------------------------------- ------------------------------------------------------------ -------NVRKSP----------------------------------------------- ---------------I--------------SRFAKIARLAS----------------GKR KA-KKE-----KW-------ANLVDATK-------------------------QVRDAFN RSRSMDSI-------------S-----------------SQISSEQASTKGETSPSDSSL SG-VG--------SLGEETSEEESPKRVDQ-------------ATNTETPALKWSRITRK ---LGMLTFHPTKFKVVLHEKNDNTLEPPPSKLISK------KSKARRTVSAPSASLH-- PPQNSFNAQQR----------------------------------------TNRTTSTSF NSV---IP----ET-KRLPTIEYSPRNSLA-PE--MPSPVEN--A---PCSS----PP-- -----------------RTPVSCSSFPDTG--------RLESSK-AE------SDI-IKN SGM---PASEVT--SLNQSSSL--EP-LVNGNGKSKERSLGLISTLYGIEPVNKDMTM-- --GWL >Limulus:polyphemus_Atlantic:horseshoe:crab_XP:013791151.2_Arthropoda_TRPgamma ------------------------------------------------------------ ----------------------------------MDIEAGYG------------------ ------------------------------------------------------------ ------------------------------------------------YTSIQKSMYN-- ------------------------------------------------------------ ----MNKSTIENGSQAVRA----------------------------------------- --------------EGQLRM-----------------------------EE--------- -----------KKF---------------------------------------------- ---------------LLVVERGDVASVRR------------------------------- ------------------------------------YLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TAKETGNIDF-------- ---------------------------NCVDPL--------------------------- ---GRS----ALLMAIE------------------------------------NENLEMV ELLLEFK----------------------------------------------------- ------------------------------------------------------------ --------------------VETKD-----------------------------GLLHAI SEEYVEAVELLLDHE--------DATHTP------------------------------- ------------------------------------------------------------ -----GEPHSWE------------------------------------------------ -------------------------------------AIDRDTATF-------------- ------TPDIT-------------PLCLAAH----------------------------- ------------------------------------------------------------ --------------------RDNYEILKILLD------RGAKFPVPH------------- -----------------DARCGCKTCMESSLEDSLRHSRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RINAYRAL-------------------------------------------- --------------------------------------AAPSM----------------- -------------------------------------------IALSSKDP--------- -----ILTAFELSWELRRLSFME-HEFK------------------SEYQELRRRCQNFA TAL---LDHTR-TTYE-------------------------------------LEVLLNY -DP-----------SGPAFE----H--------GDRMNLSRLKLAIK-----YKQKKFCA HSNVQQLLASLWYEGLPGFRRKN------------------------------------- --------VVLQSLEICRIGTLFPVYSI-------AYILAP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----HSFYGRIIRRPFIKFI-------CH-------------SASYITFLFLLIL----- ----ASQRIETV---------------------------LVDLFGSEEA-KRRMRS---- ------------------------------------------------------------ ----------------------------------------EVITKRGAPPSVVEWMI-LA WVLGLIWSEIKQLWD--------------------------------------------- -----------------------------YGLIEY------VNDMWNIIDFITNSLYVAT VAL-RIVAYFQVQKEI----------ALKTGTAFL----------PRERWDAWDPILISE GLFAAANIFSSLKLVYIF-SVNPHLGPLQISLGRMV-IDILKFLFVYTLVLFAFACGLNQ LLWYYAEMERQTC-----HKSLHN--LYKKSDSGA--CLTWR-------R-FAN--LFES SQTLFWASFGL---------------IDLD--------------------NFELTGIK-- ---------------------------------------------------------SYT RFWGMLMFGCYSVINIVVLLNLLIAMMNHSYQMISEQADT------------EW------ ---KFARSKLWMSFFED---GGTVPPPF----------NIIPT----------------- ---------------------------------------------------PKSIYYLFR WMFRKF---------------------------------CGHS----------RSAKIEH LKTI---------------------------------------RRKAKQA---------- ---------------------------NERDIRYQT--IMRN------------------ ----------------LVRRYVTKEQRKADN-QGVTEDD---------------VN---- ----------------------------EIKQDISSFRYELIEIL--------------- ----------------------------------KNS---------------GFNTSSAK -D-QTK------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GGG GKKGRQKERR------------------------------------------LMKGFNIG L---------------------------------------------VEGSLPT------- ----------------------------------------------IHG-LNL--S---- ------------------------------------------------------------ ------------------------------------------------------------ ---------KKSA----------------------------------------------- ---------------V--------------NRITRLARMSS----------------DKR HV-KQG-----KW-------KNFMDATR-------------------------SARAAFT RSRSEESI-------------S-----------------SQGSSGQQS-QIEIS-SESSV S--VM--------FTPEYDSEQESRPAHSQNQRLGC-----TATSDMQTEAKRLSRLSRK ---FGSLSFNPSKLRLVFQDHNKFT---PRVQSVPKLSGFPEKKKAERTISAPSSKVTAV PAKSEPNSSEE----------------------------------------GKR-PSTTL SLT---TPNVSVER-NLSPIQSYAGSNSHT-PKTSLTRICES--SVLQECSSEVVTAP-- -----------------R---------DNGTTL---NERLNDQQ-PQITKSTTSNIQIRQ NSMAVSPSSENT--DTTPTETV---------SNKTLNGSIGIMSRVYGIEPANKQMSV-- --GWI >Saccharomyces:cerevisiae:S288C_baker's:yeast_NP:014730.2_Saccharomycotina_Yvc1p ------------------------------------------------------------ ----------------------------------MVSANG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DLHLPIS--------------------------------NEQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CMP---------------------------------ENNG--SLGFEA PTP-RQILRVTLN----------------------------------------------- ------------------------------------------------------------ ------------------------LKYLIDKV---------------------------- --------------------------VPIVYD---PNDIVCDH----------------- ------SEILSPK-----------VVKLAYE--------------------------ACG GNPKDK------------------------------------------------------ --------------------ANKRKYQSVIIF---------------------------- ------------------SLLKVCEWYSILATMEVHNA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KLYETRNL-------------------------------------------- --------------------------------------ASQQL----------------- -------------------------------CK----------LLIEREET--------- ------------------------------------------------------------ ------------RD----------------------------------LQFLFMQLLLRR YVINE--------------------------NDEDQEPLNALELATD-----MHCTTVIG SSGFQRCLKWIWRGWIVQNGLD-------------------------------------- -----------------------PTTFIKDDSLAEVSLISH------------------- ------------------------------------------------------------ -----------FNPVRL------------------------------------------- ------------------------------------------------------------ ------------KAPVYQNY-------LQ-------------MIFSFLFLGLYTL----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VVNGKDSERVQSFDLLESIF-YV FNTGFILDELTKLYY--------------------------------------------- -------------------IGYA------------------HLSFWNLFNDTTYLIITFA MGF-RAMSVTPLN------AKYSSEDWDKISYRVL------------------------- ---SCAAPFVWSRLLLYL-ESQRFIGIMLVILKHMM-KESIVFFFLLFLIMIGFTQGFLG LDSADG---------------------------------------------------KRD ITGPILGNLTITV------LGLGS--FDVF------------------------------ --------------------------------------------------------EEFA PPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADD------------EY---M-- -ALMSQKTLRYIRAPDE----DVYVSPL----------NLIEVFMTP------------I FRILPPKRAK------------------------------------------DLSYTVMT IVYSPFLLLISVK-------------------------ETREARRIKYNRMKRLNDDANE YDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQRTAEQEDVH-F-------- -KV---------------------------PKKWYK--NVKKCSPSFEQY--DNDDTEDD AGE--------------------------------------------------------- ---------------------DKDEV-KELTKKVENLTAVITDLL--------------- ---------------------------------------------------EKLDIKDKK -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Saccharomyces:cerevisiae_baker's:yeast_GHM91739.1_Saccharomycotina_calcium:channel:yvc1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MEVHNA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KLYETRNL-------------------------------------------- --------------------------------------ASQQL----------------- -------------------------------CK----------LLIEREET--------- ------------------------------------------------------------ ------------RD----------------------------------LQFLFMQLLLRR YVINE--------------------------NDEDQEPLNALELATD-----MHCTTVIG SSGFQRCLKWIWRGWIVQNGLD-------------------------------------- -----------------------PTTFIKDDSLAEVSLISH------------------- ------------------------------------------------------------ -----------FNPVRL------------------------------------------- ------------------------------------------------------------ ------------KAPVYQNY-------LQ-------------MIFSFLFLGLYTL----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VVNGKDSERVQSFDLLESIF-YV FNTGFILDELTKLYY--------------------------------------------- -------------------IGYA------------------HLSFWNLFNDTTYLIITFA MGF-RAMSVTPLN------AKYSSEDWDKISYRVL------------------------- ---SCAAPFVWSRLLLYL-ESQRFIGIMLVILKHMM-KESIVFFFLLFLIMIGFTQGFLG LDSADG---------------------------------------------------KRD ITGPILGNLTITV------LGLGS--FDVF------------------------------ --------------------------------------------------------EEFA PPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADD------------EY---M-- -ALMSQKTLRYIRAPDE----DVYVSPL----------NLIEVFMTP------------I FRILPPKRAK------------------------------------------DLSYTVMT IVYSPFLLLISVK-------------------------ETREARRIKYNRMKRLNDDANE YDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQRTAEQEDVH-F-------- -KV---------------------------PKKWYK--NVKKCSPSFEQY--DNDDTEDD AGE--------------------------------------------------------- ---------------------DKDEV-KELTKKVENLTAVITDLL--------------- ---------------------------------------------------EKLDIKDKK -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Saccharomyces:pastorianus_QID82427.1_Saccharomycotina_yvc1 ------------------------------------------------------------ ----------------------------------MVSANG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DLHLPIS--------------------------------NEQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CMP---------------------------------ENNG--SLGFEA PTP-RQVLRVTLN----------------------------------------------- ------------------------------------------------------------ ------------------------LKYLIDKV---------------------------- --------------------------VPIVYD---PNDIVCDH----------------- ------SEILSPK-----------VVKLAYE--------------------------ACG GNPKDK------------------------------------------------------ --------------------ANKRKYQSVIIF---------------------------- ------------------SLLKVCEWYSILATMEVHNA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KLYETRNL-------------------------------------------- --------------------------------------ASQQL----------------- -------------------------------CK----------LLIEREET--------- ------------------------------------------------------------ ------------RD----------------------------------LQFLFMQLLLRR YVINE--------------------------NDEDQEPLNALELATD-----MHCTTVIG SSGFQRCLKWIWRGWIVQNGLD-------------------------------------- -----------------------PTTFIKDDSLAEVSLISH------------------- ------------------------------------------------------------ -----------FNPVRL------------------------------------------- ------------------------------------------------------------ ------------KAPVYQNY-------LQ-------------MIFSFLFLGLYTL----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VVNGKDSERVQSFDLLESIF-YV FNTGFILDELTKLYY--------------------------------------------- -------------------IGYA------------------HLSFWNLFNDTTYLIITFA MGF-RAMSVTPLN------AKYSSEDWDKISYRVL------------------------- ---SCAAPFVWSRLLLYL-ESQRFIGIMLVILKHMM-KESIVFFFLLFLIMIGFTQGFLG LDSADG---------------------------------------------------KRD ITGPILGNLTITV------LGLGS--FDVF------------------------------ --------------------------------------------------------EEFA PPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADD------------EY---M-- -ALMSQKTLRYIRAPDE----DVYVSPL----------NLIEVFMTP------------I FRILPPKRAK------------------------------------------DLSYTVMT IVYSPFLLLISVK-------------------------ETREARRIKYNRMKRLNDDANE YDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQKTAEQEDVH-F-------- -KV---------------------------PKKWYK--NVKKCSPSFEQY--DNDDTEDD VGE--------------------------------------------------------- ---------------------DKDEV-KELTKKVENLTAVITDLL--------------- ---------------------------------------------------EKLDIKDKK -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Candida:glabrata_XP:448082.1_Saccharomycotina_ChrJ ------------------------------------------------------------ ----------------------------------MLKYNP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PHSTVLYH---------------------------------------- ------------------------------------TLP-V------------------- -----------------------------------------------------------L YTWG--------------------------------LLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------QLM ----------SEQLPVD--------------------------------NEG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CQP---------------------------------ANSG---YNVEA PTS-RQVLRVALN----------------------------------------------- ------------------------------------------------------------ ------------------------LKYLVDKV---------------------------- --------------------------VPVTYG---CDEIESDH----------------- ------SSVVTPA-----------VVQLALE--------------------------ACG GDPEDK------------------------------------------------------ --------------------KNRDKYRAVVVF---------------------------- ------------------ALLKVYGWYSQLAATELHNA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ELYESRGV-------------------------------------------- --------------------------------------AAQQL----------------- -------------------------------CK----------IIIDQEEM--------- ------------------------------------------------------------ ------------ND----------------------------------LHFMFMQMLLRR YTINE--------------------------NDEDSEPANAIELASD-----MHCTIVIG SGGFQRCLTWLWRGWIIQNRRD-------------------------------------- -----------------------PTTFIRDETVSSPYFIDH------------------- ------------------------------------------------------------ -----------FNPDRI------------------------------------------- ------------------------------------------------------------ ------------KTPKYQNL-------LN-------------IFFSILFLVLYTV----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VVNGKNSVTVSPIDLPELVF-YL FTLGNILEEMTKMYY--------------------------------------------- -------------------IGAA------------------YFSFWSSFNLTMYSIISVS FVL-RILSVAPLK------LHNPSEYWDKISYRIL------------------------- ---SCAAPFVWSRMLLYL-ESEPFVGVMLVVLKHMM-KESAVFFVLLVLIMVGFCQGFLG LDSADG---------------------------------------------------HRE ITGTIMENLTIAV------LGLGS--FDKF------------------------------ --------------------------------------------------------KRFA PPYAEILYYSYYFIVSVILLNILIALYANAYQRVVDNAAD------------EY---M-- -ALMVQKTLRFIRAPDE----DVFVAPL----------NLIELLFSP------------V FAFLSKAKKS------------------------------------------QLSYYVMM VIYSPTLVLVALS-------------------------EVRTSKRIKYNRLKNLPDDANE VDTAWDLTDGYVDEEDTLFTRSHTSGIRATNKKNKFSLQVQREAEAKDPK-F-------- -SV---------------------------PREWYS--KVKHICHKHEQEKCASDDGSND LSE------------K-VSELLVKLSKVGLSVNSSGSST--------------------- ---------------------LPDEVFKEFKTDVEKLGNMVQELN--------------- -----------------------------------------------DLKRELKDISD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M KSLLKEIVN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------QKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Candida:glabrata_KTB11272.1_Saccharomycotina_Calcium:channel:YVC1 ------------------------------------------------------------ ----------------------------------M------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------SEQLPVD--------------------------------NEG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CQP---------------------------------ANSG---YNVEA PTS-RQVLRVALN----------------------------------------------- ------------------------------------------------------------ ------------------------LKYLVDKV---------------------------- --------------------------VPVTYG---CDEIESDH----------------- ------SSVVTPA-----------VVQLALE--------------------------ACG GDPEDK------------------------------------------------------ --------------------KNRDKYRAVVVF---------------------------- ------------------ALLKVYGWYGQLAATELHNA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ELYESRGV-------------------------------------------- --------------------------------------AAQQL----------------- -------------------------------CK----------IIIDQEEM--------- ------------------------------------------------------------ ------------ND----------------------------------LHFMFMQMLLRR YTINE--------------------------NDEDSEPANAIELASD-----MHCTIVIG SGGFQRCLTWLWRGWIIQNRRD-------------------------------------- -----------------------PTTFIRDETVSSPYFIDH------------------- ------------------------------------------------------------ -----------FNPDRI------------------------------------------- ------------------------------------------------------------ ------------KTPKYQNL-------LN-------------IFFSILFLVLYTV----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VVNGKNSVTVSPIDLPELFF-YL FTLGNILEEMTKMYY--------------------------------------------- -------------------IGAA------------------YFSFWSSFNLTMYSIISVS FVL-RILSVAPLK------LHNPSEYWDKISYRIL------------------------- ---SCAAPFVWSRMLLYL-ESEPFVGVMLVVLKHMM-KESAVFFVLLVLIMVGFCQGFLG LDSADG---------------------------------------------------HRE ITGTIMENLTIAV------LGLGS--FDKF------------------------------ --------------------------------------------------------KRFA PPYAEILYYSYYFIVSVILLNILIALYANAYQRVVDNAAD------------EY---M-- -ALMVQKTLRFIRAPDE----DVFVAPL----------NLIELLFSP------------V FAFLSKAKKS------------------------------------------QLSYYVMM VIYSPTLVLVALS-------------------------EVRTSKRIKYNRLKNLPDDANE VDTAWDLTDGYVDEEDTLFTRSHTSGIRATNKKNKFSLQVQREAEAKDPK-F-------- -SV---------------------------PREWYS--KVKHICHKHEQEKCASDDDSND LSE------------K-VSELLVKLSKVGLSVNSSGSST--------------------- ---------------------LPDEVFKEFKTDVEKLGNMVQELN--------------- -----------------------------------------------GLKRELNDISE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M KFLLKEIVN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------QKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----- >Colletotrichum:graminicola_XP:008097990.1_Pezizomycotina_potassium:ion:channel:Yvc1 ------------------------------------------------------------ ----------------------------------MPVLQS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------L--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PLAYK------------------------------------------- ------------------------------------------------------------ -----------------RVYC--------------------------------------- ---------PAPVLP------------------QYR------------------SEDLES AIPAPEVTKIALK----------------------------------------------- ------------------------------------------------------------ ------------------------LRHLVELA---------------------------- --------------------------VPCELD---EDDITKAH----------------- ------STIITK------------KVIKAAK----------------------------- ------------------------------------------------------E----- --------------------AGGSHYGSCVVF---------------------------- ------------------CLIVCKRWFKHQALTELWDA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------DLHRVRAV-------------------------------------------- --------------------------------------ACEVI----------------- ----------------------------------------AKQIIEGEEDL--------- ------------------------------------------------------------ -------------------------------------------------QYLMHSVLLRR YSIIV--------------------------DGKSTPPANVIEKAVD-----LHAVRVIG SSGYQKCISYLWKGWLVQDEND-------------------------------------- -----------------------PSVFVDYKDKTNPSFLVH------------------- ------------------------------------------------------------ -----------MDPDRI------------------------------------------- ------------------------------------------------------------ ------------RAPMYQNA-------TQ-------------VIISLVYIGLYTA----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VINSVNAK--GVLDSAEVLL-YI FTLGFICEEVTKFWK--------------------------------------------- -------------------AGYH------------------ILGFWNAFNGILYSFISLS LIL-RIIGLTHGE------GEDARKYYSELSYNFL------------------------- ---AFSAPMIWSRLLLYL-DSFRFFGAMLVVLKVMM-KESIIFFALLAVLIIGFLQAFVG LDLADDLVAEDI----T----------------------------------F----IMSA MANAIMQ----------------SPDFSGF------------------------------ --------------------------------------------------------DKFS PPFGIILYYCFTFIVMVVLLNILIALYNSAYEDIYDNAND------------EY---L-- -TLFAQKTMQFVRAPDE----NVYIPPF----------NLIEMVVIG------------L FWWMEKSKFE------------------------------------------RMSDFIMG FIYSPVLVFAAVF-------------------------ETRSAAEIRSNRAR-------- -------------------------------------------GEEDDDT-I-------- -------------------------------EEWEQ----------------MMDQVDFE --------------SDGWNKVCITAKTDLDVDPTISEVQ--------------------- ----------------------------KLRSEVEELKKMLVDIS--------------- -----------------------------------KAVSA-GNAGNTQATNNLIDLGETT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------APAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGSDKN KKRSKKGNK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------NKNNQQ PTG----------------------------------------------------DDGKA PGG-----SSSSDE---------------------------------------------- ------------------------------------------------------------ ------------------------E----------------------------------- ----- >Colletotrichum:incanum_KZL78996.1_Pezizomycotina_potassium:ion:channel:Yvc1 ------------------------------------------------------------ ----------------------------------MANFNW-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------V--------- ------------------------------------------------------------ -------------------------------------------------SR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MLG--------------------- ------------------------------WDR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HPRHHHDFHSDWIR------------------------- --DDRR----RPPIAYK------------------------------------------- ------------------------------------------------------------ -----------------RVYC--------------------------------------- ---------PELVLP------------------QYR------------------SEHLES AIPAPEVTKIALK----------------------------------------------- ------------------------------------------------------------ ------------------------LRHLIELA---------------------------- --------------------------VPCELD---EDDITRAH----------------- ------SKIITT------------KVITAAK----------------------------- ------------------------------------------------------E----- --------------------AGGSHYGSCVVF---------------------------- ------------------CLIVCKRWFKHQALVELWDA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------DLHRVRAV-------------------------------------------- --------------------------------------ACEVV----------------- ----------------------------------------AKQIIESEEDL--------- ------------------------------------------------------------ -------------------------------------------------QYLMHSVLLRR YSIVV--------------------------DGESTPPANVIEKAVD-----LHAVRVIG SSGYQKCISYLWKGWLVQDEND-------------------------------------- -----------------------PAVFVDYKDKTNPSFLVH------------------- ------------------------------------------------------------ -----------MDPDRI------------------------------------------- ------------------------------------------------------------ ------------RAPMYQNA-------TQ-------------VLISLVYIGLYTA----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VINSVNAK--GVLDSAEVLL-YI FTLGFICEEITKFWK--------------------------------------------- -------------------AGYH------------------ILGFWNAFNGVLYSFISLS LVL-RIIGLTHGE------GEEARKYYSELSYNFL------------------------- ---AFSAPMIWSRLLLYL-DSFRFFGAMLVVLKVMM-KESIIFFALLAVLIIGFLQAFVG LDLAEDLVADDI----L----------------------------------F----IISA MANAIMQ----------------SPDFDGF------------------------------ --------------------------------------------------------DKFS PPFGIILYYCFTFIVMVVLLNILIALYNSAYEDIYDNAND------------EY---L-- -ALFAQKTMQFVRAPDE----NVYIPPF----------NLIEMVVIS------------L FWWMEKSKFE------------------------------------------RMSDIIMG ILYSPVLIVAAVF-------------------------ETRSAAEIRSNRAR-------- -------------------------------------------GEEDDDT-I-------- -------------------------------EEWEQ----------------MMDQVDFE --------------SDGWNKVCITAKTNLDTDPTISEVQ--------------------- ----------------------------KLRSEVEELKKMLVDIS--------------- -----------------------------------KAVSG-GNAGN-AQASNLIDLGEPA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EGSSKK KKKNKKGKK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------SKKDKQ PAG-----------------------------------------------------DGQA SGG-----SSSSDE---------------------------------------------- ------------------------------------------------------------ ------------------------E----------------------------------- ----- >Colletotrichum:tofieldiae_KZL77822_Pezizomycotina_potassium:ion:channel:Yvc1 ------------------------------------------------------------ ----------------------------------MANFNW-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------V--------- ------------------------------------------------------------ -------------------------------------------------SR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MLG--------------------- ------------------------------WDR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HPRHHHDFHSDWIR------------------------- --DDRR----RPPIAYK------------------------------------------- ------------------------------------------------------------ -----------------RVCC--------------------------------------- ---------PEPVLP------------------QYR------------------SEHLES AIPAPEVTKIALK----------------------------------------------- ------------------------------------------------------------ ------------------------LRHLVELA---------------------------- --------------------------VPCELD---EDDITRAH----------------- ------SKIITT------------KVVKAAK----------------------------- ------------------------------------------------------E----- --------------------AGGSHYGSCVVF---------------------------- ------------------CLIVCKRWFKHQALVELWDA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------DLHRVRAV-------------------------------------------- --------------------------------------ACEVI----------------- ----------------------------------------AKQIIESEEDL--------- ------------------------------------------------------------ -------------------------------------------------QYLMHSVLLRR YSIVV--------------------------DGESTPPANVIEKAVD-----LHAVRVIG SSGYQKCISYLWKGWLVQDEND-------------------------------------- -----------------------PAVFVDYKDKTNPSFLVH------------------- ------------------------------------------------------------ -----------MDPDRI------------------------------------------- ------------------------------------------------------------ ------------RAPMYQNA-------TQ-------------VLISLVYIGLYTA----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VINSVNAK--GVLDSAEVLL-YI FTLGFICEEMTKFWK--------------------------------------------- -------------------AGYH------------------ILGFWNAFNGVLYSFISLS LVL-RIIGLTHGE------GEEARKYYSELSYNFL------------------------- ---AFSAPMIWSRLLLYL-DSFRFFGAMLVVLKVMM-KESIIFFALLAVLIIGFLQAFVG LDLAEDLVADDI----L----------------------------------F----IISA MANAIMQ----------------SPDFDGF------------------------------ --------------------------------------------------------DRFS PPFGIILYYCFTFIVMVVLLNILIALYNSAYEDIYDNAND------------EY---L-- -ALFAQKTMQFVRAPDE----NVYIPPF----------NLIEMVVIS------------L FWWMEKSKFE------------------------------------------RMSDIIMG ILYSPVLVVAAVF-------------------------ETRSAAEIRSNRAR-------- -------------------------------------------GEEDDDT-I-------- -------------------------------EEWEQ----------------MLDQVDFE --------------SDGWNKVCVTAKTDLDTDPTISEVQ--------------------- ----------------------------KLRSEVEELKRMLVDIS--------------- -----------------------------------KAVSG-GSAGN-AQASNLIDLGEPG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EGSSKK KKKNKKGKK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------SKKDKQ PAG-----------------------------------------------------DGQA SGG-----SSSSDE---------------------------------------------- ------------------------------------------------------------ ------------------------E----------------------------------- ----- >AILME03430_D2HZL7_HOG_0407993_1c_6g_7d_4d_2b_Ailuropoda_melanoleuca_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGEPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----GGVTFHTYTNSTVGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >CANLF16803_F1PBP9_HOG_0407993_1c_6g_7d_4d_2b_Canis_lupus_familiaris_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGEPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----GGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >FELCA09465_ENSFCAG00000004708_HOG_0407993_1c_6g_7d_4d_2b_Felis_catus_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGEPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----GGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERDSQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >MYOLU07349_G1NZA6_HOG_0407993_1c_6g_7d_4d_2b_Myotis_lucifugus_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGDPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----GGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERDSQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >MOUSE31141_KCNA2_MOUSE_HOG_0407993_1c_6g_7d_4d_2b_Mus_musculus_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGDPVDEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----GGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERDSQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >BOVIN14107_F1MKB0_HOG_0407993_1c_6g_7d_4d_2b_Bos_taurus_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGDPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----SGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >HUMAN01399_KCNA2_HUMAN_HOG_0407993_1c_6g_7d_4d_2b_Homo_sapiens_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGDPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----SGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >SHEEP00641_W5PQ46_HOG_0407993_1c_6g_7d_4d_2b_Ovis_aries_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGDPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----SGVTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >MUSPF05978_M3Z865_HOG_0407993_1c_6g_7d_4d_2b_Mustela_putorius_furo_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGEPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----SGMTFHTYSNSTIGYQ---QSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >PIGXX24491_Q1AP78_HOG_0407993_1c_6g_7d_4d_2b_Sus_scrofa_KCNA2 ------------------------------------------------------------ ----------------------------------MTVATGDPADEA-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AALP---------GH------------------- ------------PQDTYDPEA--D------------H----------------------- ------------------------------------EC----------CER--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VVIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ISGLR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------FETQLK-----TLAQF------------------ ------------------------PETLLGD----------------------------- ------------------------------------------------------------ ----------------P---KKRMRYFDPLRNEYFFD----------------------- --------------------------RNRPSFDAILYYYQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGGRLRRPVNVP---------------------------------LDI------- --------------------------------------FSEEI-------R--------- -------------------------------------------FYELGEEA--------- ------------------------MEMF-------------------------------- -----REDEGYIKEEERPLPENE---------------------------FQRQVWLLFE YPE-----------SSG--------------PARIIAIVSVMVILIS------------- ------------------------------------------------------------ --------------IVSFCLETLPIFRD-------------------------------- ------------------------------------ENEDMH------------------ -----------------------G------------------------------------ ------------------------------------------------------------ ----SGVTFHTYSNSTVGYQ---PSTSFT----------DPFFIVETLCIIWFSF----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EFLV--R F---FAC-------P--------------------------------------------- ------------------------------SKAGF------FTNIMNIIDIVAIIPYFIT LGT-ELAEKPE-----D-----AQQGQQAMSLAIL------------------------- ---RVIRLVRVFRIFKLS-RHSKGLQILGQTLKASM-RELGLLIFFLFIGVILFSSAVYF AEADERESQ------------------------------------------FPS--IPDA FWWAVVSMTTVGYGD--------------------------------------------- ---------------------------------------------------------MVP TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------------------- ---EGEEQAQYLQVTSC----PKIPSSP-------------------------------- --DLKKSRSA-------------------------------------------------- --------------------------------------------------STISKSDYME IQEG---------------------------------------VNNSNED---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FREENLKTANCTLANTN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YVN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IT----------------- --------KMLTDV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----- >AILME10395_G1L504_HOG_0434470_3hih_1046c_633d_412b_223p_Ailuropoda_melanoleuca_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPESFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKAEGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSLFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEGAGSPRSSSEVSKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRG--RFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYRP-GAPSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHIGGRLLPEVKIDKAATEDS---ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE----------------------------VTTELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMNDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWAKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDVKPDVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEIRFDIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIIFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTVGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >BOVIN15621_F1MMU9_HOG_0434470_3hih_1046c_633d_412b_223p_Bos_taurus_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKADGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYITEFVNLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEDGAGSPRSSSEISKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHISGRLLPE--------------ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMHDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWIKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNESSEIRFEIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIVFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------NLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >PIGXX25319_A0A287BS01_HOG_0434470_3hih_1046c_633d_412b_223p_Sus_scrofa_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKADGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEDGVGSPRSSSEISKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHISGRLLPE--------------ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMHDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNESSEIRFEIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIVFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTP--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >HUMAN06428_SCN8A_HUMAN_HOG_0434470_3hih_1046c_633d_412b_223p_Homo_sapiens_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKADGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYITEFVNLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEGGGSPRSSSEISKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKAFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHIGGRLLPEVKIDKAATDDS---ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSIMSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMHDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEIRFEIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIVFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >CANLF10791_E2R0F0_HOG_0434470_3hih_1046c_633d_412b_223p_Canis_lupus_familiaris_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKAEGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSLFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYITEFVNLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEGAGSPRSSSEISKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHIGGRLLPE--------------ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMNDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWAKLKVHAFMQAHLKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEIRFDIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIIFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >MUSPF03966_M3Y908_HOG_0434470_3hih_1046c_633d_412b_223p_Mustela_putorius_furo_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKAEGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEGAGSPRSSSEISKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHIGGRLLPE--------------ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMNDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWAKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEIRFEIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIIFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERARRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >FELCA07905_ENSFCAG00000004415_HOG_0434470_3hih_1046c_633d_412b_223p_Felis_catus_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKAEGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSLFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTRGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEGVGSPRSSSEVSKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHIGGRLLPE--------------ATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCQLPRW---HMNDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWAKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEIRFEIEEVNNKTD------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDQQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIIFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFVCKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >SHEEP14304_W5Q748_HOG_0434470_3hih_1046c_633d_412b_223p_Ovis_aries_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKADGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSLFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEGAGSPRSSSEISKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGLRRKGFRLPDN RIGRKFSIMNQSLLGIPVPPSPPRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSY----GKNQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHISGRLLPEVKIDKAATDDSHIGATTEVEIKKKGPGSLLVSMDQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMHDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWIKLKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNTEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNESSEIRFEIEDVNNKTE------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIVFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------NLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKTT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >MOUSE14758_F7D6K4_HOG_0434470_3hih_1046c_633d_412b_223p_Mus_musculus_SCN8A ------------------------------------------------------------ ----------------------------------MAARLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKADGSHRE-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEDGVGSPRSSSELSKLSS----------------------------------- -KSAKERRNRRKKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKAFRLPDN RIGRKFSIMNQSLLSIPGSPFLSRH--NSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE ESEGRR---DSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVV SLI-GPGSHI-GRLLPE--------------ATTEVEIKKKGPGSLLVSMEQLASYGRKD RINSIMSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKISQECKLPRW---HMNDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWAKVKVHAFMQAHFKQREADEVKPLDELYEKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGVDIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENLNTEDVS-------- ------------------------SESDP--------------EGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRKTIRTILE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEIRFEIDEVNNKTD------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIVFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMENILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICRKIT--------------- --------------------------------------------------SNKLENGGTH RE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPDKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- ----- >MYOLU09446_G1PEQ5_HOG_0434470_3hih_1046c_633d_412b_223p_Myotis_lucifugus_SCN8A ------------------------------------------------------------ ----------------------------------MAGRLLAPPGPDSFKPFTP------- ------------------------------------------------------------ --ESLANIERRIAESKLKKPPKGDGSHRD-------------------DDEDSKPKPN-- --------------------SDLEAGKSLPFIYGDI-PQGLV------------------ ----------AVPLEDFDPYYLTQK------------TFVVLNRGKTLFRFSATPALYIL S-------PFNLIRRIAIKILIHSLFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGI YTFESLVKIIARGFCIDGFTFLRDPWNWLD-------FSVIMMAYVTEFVDLGNVSALRT FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC VVWPINFNDSYLENGTRGFDWDEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMK AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFY LVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED AIEE-EGEEEGGSPRSSSEMSKLSS----------------------------------- -KSAKERRNRRRKRKQKELSEGEEK----------GDPEKVFKSESEDGMRRKGFRLPDN RIGRKFSIMNQSLVSIPGSP-LSGH--NSKSSI-QLRGPGRFRDPGSENEFADDEHSPVE ESEGRR---DSLFIPIR-RERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV SLIGGPGSHIGGRLLPE--------------GTTEVEIKKKGPGSLLVSMEQLASYGRKD RINSILSVVTNTLVE-------------------------------ELEESQR------- ------------KCP--PCWYKFANTFLIWEC--HPYWIKLKEIVN--------LIVMDP FVDLAITICIVLN------TLFMAMEHHPMTPQFEHVLSVGNLVFTGIFTAEMFLKLIAM DPYYYFQE----------------GWN----------------------------IFDGF IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRW---HMHDFFHSFLIVFRVLCG----- ----EWIETMWD------------CMEVAGQ----------------------------- -----------------------------------------------------------A MCLI--------VFMMVMV-IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVI RIKKGVAWTKVKVHAFMQAHFKQREADEVKPLDEMYDKKAN------------------- ---------------------------CIANH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----TGADIHRNGDFQKNGNGTT-----------------SGIGSSVEKYII------- -------------DEDHMSFI-----------------NNPNL-----TVR--VPIAVGE ----------------------------------------SDFENVNTEDVS-------- ------------------------SESDP--------------DGSKDKLDDTSSSEGST IDIKPEVEEVPVEQPEEYLDPEACFTEGCVRRFKCCTVNIEEGLGKSWWILRKTCFLIVE HNWFETFIIFMILLSSGALAF----------EDIYIEQRRTIRTVLE-----YADKVFTY IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLVANALGYSELGAIKSLRTLRAL RPLRALSRFEGMRVVVNALVGAIPSIMN-VLLVCLIFWLIF------------------- ---SIM-GVNLFAGKYHYC---------------FNETSEERFEIEIVNNKTD------- ---C--------------EKLMEGNNTEIRW----------------------------- -------------------KNV----------------KINFDNV--------------- ----GAGYLALLQVATFKGWMDIMYAAVDSRKPEEQPKYEDNIYMYIYFVIFIIFGSFFT LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ----KPIPRPLNKI QGIVFDFVTQQAFDIVIMM----------------------------------------- -----LIC------------------------LNMVTMMVETDTQSKQMETILYWIN-LV FVIFFTCECVLKMFA--------------------------------------------- -------------------------------LRHYY-----FTIGWNIFDFVVVILSIVG MFLADIIEKYFVSPTLF------------------------------------------- ---RVIRLARIGRILRLI-KGAKGIRTLLFALMMSL-PALFNIGLLLFLVMFIFSIFGMS NFAYVKHEAGID-----------------------------------DMFNF------ET FGNSMICLFQITTSAGW--DGLLLPILNRP-PDC------------------SLDKEH-- -----------------------------------------------PGSGFKG--DCGN PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIW-EKFDP DATQFIEYCKLADFADALEHPLRVPKPN--------TIELIAM----------------- --DLPMVSGD------------------RIHC-------------------LDILFAF-- --------------------------------------------------TKRVLGDSGE LDIL---------------------------------------RQQMEER-FV------- -------------------------ASNPSKVSYEP------------------------ --------------------ITTTLRRKQEEVSAVVLQR--------------------- ----------------------------AYRGHLARRGFICKKIA--------------- --------------------------------------------------SNKLENGGTH PE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KKESTPSTAS------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LPS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VT-------KPEKEKQQRA EEGRRERAKRQKEV---------------------------------------------- -----------------R------------------------------------------ ---------ESKC----------------------------------------------- -----