From the 2022 paper in Science Advances entitled “The extinct shark Otodus megalodon was a transoceanic super-predator: inferences from 3D modelling” By Jack A. Cooper, John R. Hutchinson, David C. Bernvi, Geremy Cliff, Rory P. Wilson, Matt L. Dicken, Jan Menzel, Stephen Wroe, Jeanette Pirlo and Catalina Pimiento This dataset includes the following files: 1) README_3Dmegalodon.txt – provides caption information on all files in the dataset. 2) 3D Megalodon Blender tutorial.docx – A step by step guide to the construction of the Otodus megalodon 3D model 3) Data S1.xlsx – Divided into two sheets. Vertebral column and Species comparisons. Vertebral column: Measurement data of IRSNB P 9893 vertebral centra. Variables are as follows: Species - Latin/scientific name of the specimen; Specimen # (Gottfried et al. 1996) - the original catalogue number; Specimen # (publication) - the current catalogue number; Fossil type - identified fossil material; Drawer - the drawer in which each fossil of the specimen is kept; Centra # - centrum number; Label - the original label associated with each fossil; Preservation - the preservation state of all vertebrae, labelled as follows: 0) fragmentary; 1) partial preservation; 2) near-complete; Preserved Diameter (mm) - the measured diameter of each vertebra Species comparisons: Feeding strategy, thermoregulatory ability, body mass and cruising speed for 28 extant species and the Otodus megalodon model used in swim speed analysis. Variables are as follows: Common name - the laymen name for each shark species; Species name - the taxonomic/scientific name of each shark; Sp. # - number assigned to each species; Largest? - identification of a certain individual is the largest of its species recorded in the data; Thermoregulation - the physiology of a species: ectotherm or mesotherm; Feeding - the feeding mechanism of each species: filter feeder or macropredator; Body length (m) - total length of each individual, measured in metres; Mass (kg) - the body mass of each individual, measured in kilograms; Mean cruising speed (m/s) - the mean absolute cruising speed of each individual, measured in metres per second; Mean cruising speed (BL/s) - the mean relative cruising speed of each individual, measured in body lengths per second; Min cruising speed (m/s) - the minimum absolute cruising speed of each individual, measured in metres per second; Max cruising speed (m/s) - the maximum absolute cruising speed of each individual, measured in metres per second; Log mass - the logarithm of body mass of each individual; Log speed - the logarithm of absolute cruising speed of each individual; Log BL/s - the logarithm of relative cruising speed of each individual; Reference - the literature source associated with each individual 4) Data S2.Blend – Blender file of the final completed model of Otodus megalodon. Model constructed by Jack A. Cooper. 5) Data S3.Blend – Blender file of the full-body 3D scan of a 2.56 m, 164 kg Carcharodon carcharias individual used to aid flesh reconstruction in the 3D modelling. Retrieved and scanned by Matt L. Dicken. 6) Data S4.Blend – Blender file of UF 311000; an associated Otodus megalodon dentition used to reconstruct the model’s jaws. Jaws reconstructed by Jeanette Pirlo. 7) Data S5.Blender – Blender file of IRSNB P 9893; the Otodus megalodon vertebral column used as the main basis for the 3D reconstruction. Column reconstructed by Jeanette Pirlo. Data collected by Jack A. Cooper, supervised by John R. Hutchinson and Catalina Pimiento. Contact jackacooper33@gmail.com, jhutchinson@rvc.ac.uk or catalina.pimientohernandez@pim.uzh.ch for assistance.