72 1561 CAE1323611.1_unnamed_protein_product__Sepia_pharaonis_ -M-----------------------------------------------------------------------------------------------------LDEIT---------------TTTVPGKTSTHRK-------INKLMMEKRRRTRINNCLVELKTLVLKALKKDIYLSIYLSIYLSIYLSIYLSIYRSLFISIYLSIAVSSYLSIYLSQSLHIYLSIYRSLFISIYLSIAVSSYLSIYLYVCVSQSVNIYLNLFLSTYISRYIHQIIDEGEQFSKLEKVDILEMTVKYLRFLHQQSQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGGKYRVPL-DVSAEVMHYMNS-----E---EARNRLTDH-MSKCVRVP-SATSPALAT-----------------------------------------TTTSQ-----------PTPMP---------AHQQPQ--------------------QHHQIPI------------PQATD---PIR-HG----------------------------------------HPLGSVFVKN------------------------------------------------------------------------------------------------------------------------------------------------------------------TGH---------------------LMLPISS--------------------KHSK-TSLMMA---GETSYK--------------------------------------------------------------------SLTVPYVTAASASP----------------------------TPSTSGTQST-HVANT----------------------------------PIPS--------VSNI-SPAN-------------------SPTVVQMKTLC----------LSFLVSIFFLFSFFFLSFFFLSSFFFLSFFFLSFFILSSFFSSFIFLSFFLSFFVGFFFSFSLVTSFPLLLFIFFVSFFSHARACRHKHKLSFSLPLSHSH--S----------LSLSLSPSLSLSLSPSLSVSLSLSLSLSLSLSHSL------------SPSPSLSVSLSL--------------SLSLSHFLSLSPSLSPSL--------------SLTLPLSL---------PLSFS-----------------LSYSLPNFF----------------------------------------------------------------------------------------------------------------------------IL SRIE01028128.1_Euprymna_scolopes ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEQFSKLEKVDILEMTVKYLRFLHQQSQI--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGSKYRLPM-DVSAEVIQYMNS-----E---EVRSRLTDP-LSKCSRVP-STSPSTMG-------------------------------------------PASP-----------PTPMP---------AHQQPQ-----------------------QLPI------------HRGVD---PVR-HG---------------------------------------AHQLGGVFIKN------------------------------------------------------------------------------------------------------------------------------------------------------------------TGH---------------------LMVPIST--------------------KHSE-NSLMIAT--SESSYK--------------------------------------------------------------------SLTVPYVSAPSASP----------------------------TPSTSAAHSTQHVVST----------------------------------RVPS--------VSAI-SPAN-------------------SPTLLQMKTLV----------TENSVA-----------------------------------------------------GGCYVSAVPL------------------------YL-------------------------GTMNTA-------------------SHL---------------APTLS-------------------GYYTSQSPKTNNVQEN----------------EENLPVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- isotig04745___ORF_10__frame_3__translation -MRNC-----------------------------------------------------------------------------------------FCILQKPRCWTKLQ---------------PTTVPGKTSTHRK-------INKLMMEKRRRTRINNCLVELKTLVLKALKKD---------------------------------------------------------------------------------------------------------GEQFSKLEKVDILEMTVKYLRFLHQQSQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGGKYRVPL-DISAEVMHYMNS-----E---EARNRLTDH-MSKCVRAP-SATSPSMA------------------------------------------VTTSQ-----------PTPMP---------AHQQPQ---------------------QQQIPM------------PQATD---PIR-HG----------------------------------------HPLGNVFVKN------------------------------------------------------------------------------------------------------------------------------------------------------------------TGH---------------------LMLPVSS--------------------KHSE-NGLMMA---GETSYK--------------------------------------------------------------------SLTVPY---ASSSP----------------------------VPSTSGTHPT-HVVST----------------------------------PIPS--------VSSV-SPAN-------------------SPTIVQMKTLV----------TENNIT-----------------------------------------------------GGCYVSAVPL------------------------YL-------------------------GTMHTP-------------------SHT---------------CLNISRVLCIT---------IHENKQWTRSRTESSSVETV----------------VEINQINH---------------------------------------------------------------------------------------------------------------------------------------------------------------------- VCCN01006982.1_Architeuthis_dux_isolate_ADU_2019_434 ---------------------------------------------------------------------------------------------------------------------------------------Q-------MNKLLMEKRRRTRINNCLVELKTLVLKALKKD---------------------------------------------------------------------------------------------------------GEQFSKLEKVDILEMTVKYLRFLHQHSQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LAGKYRVPL-DVSAEVMHYMNS-----E---EARNRLTDH-MSKCVRVP-NATPPAMG------------------------------------------TVTSQ-----------PTPMP---------AHQQPQPQPQ--------------QQRQQQIPI------------PQATD---PIR-HG----------------------------------------HPLGSVFVKN------------------------------------------------------------------------------------------------------------------------------------------------------------------TGH---------------------LMLPISS--------------------KHSE-NGLMMA---GETSYK--------------------------------------------------------------------SLTVPYASAASASP----------------------------VPSTSGTHPT-HVVST----------------------------------SIPS--------VSNI-SPAT-------------------SPTVVQMKTLV----------TDNNVT-----------------------------------------------------GGCYVSAVPL------------------------YL-------------------------GTMHTP-------------------SHN---------------APTLA-------------------GYYTSQPIKTNNGQEV----------------EQNLPVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_029657891.2_transcription_factor_HES_4_A__partial__Octopus_sinensis_ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FQGEQFSKLEKVDILEMTVKYLRFLHQQQQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------LTSDS-LGSKYRVPL-DLSAEVLRYMNS-----D---ETRNRLTDH-ISKCVRVS-NVAAATQNLPNS-------------TTHP---------------------SSTSS-----------PTAATT--------ATISAA--------------------VPHQINAT-----------PQTND---RVH-HT----------------------------------------HHTGPFVDKP------------------------------------------------------------------------------------------------------------------------------------------------------------------SAH---------------------IMLPIAS--------------------KQSE-SSFLLAAASSDSQYK--------------------------------------------------------------------TVAVSYT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P------------------------------------------------------------------------------------------------------------------------------------------------------------ VCCN01006279.1_Architeuthis_dux_isolate_ADU_2019_599 ---G-----------------------------------------HTRLPNASV--RMCGKKKKLAWESGRPQLHTQL------AGSARVPKE---------MLDSVT--------NTVA---SNAGPIKTPTHRKVSCVLFQINKLMMEKRRRTRINNCLSELKTLVLKALKKDV--SIY---------------------------------------------------------------YLSIYIY---------------------------IQGEQFSKLEKVDILEMTVKYLRFLHQQQQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGGKYRVPL-DV--EVMRYMNS-----E---EARSRLTDH-ISKCVRVS-NGSPTQPMVART---------------------------------------NTQTP----------PTPTA---------AHQQIN--------------------THQQINA------------TPSTPV--HIR-QS---------------------------------------QSPQTSPLGDN------------------------------------------------------------------------------------------------------------------------------------------------------------------TTH---------------------IVLPIAS--------------------KQSE-SSLMMAAV-PESPYK--------------------------------------------------------------------TLTVSYIN-SS-------------------------------PVSCTNSPST-HVINT----------------------------------PVNS--------LTAITSPQNTIT----------------SPSIVHMKALV----------SDSHAS-----------------------------------------------------NGCYVSTVPV------------------------YV-------------------------GSISEA-------------------KPT---------------SATLA-------------------GFYT-QPLKRHSSPEP----------------IKELPLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- SRIE01028924.1_Euprymna_scolopes ---G-----------------------------------------HTRLPSASV--RMCG--KNLAWESGRSPLHTQL------AGSARVPKE-FFKIENFTMLDSVT---------TVA---SNAGPTKTPTHRKVS----QINKLMMEKRRRTRINNCLSELKTLVLKALKKD---------------------------------------------------------------------------------------------------------GEQFSKLEKVDILEMTVKYLHFLHQQQQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGGKYRVPL-DVSAEVMRYMNS-----E---EARSRLTDH-ISKCVRVS-NGSPTQQVVPNS---------------------------------------ATQT-----------PTPTA---------VHQQ----------------------QRQQIPT------------PQTPPE--HIRHHS----------------------------------------QPQTSPLGDN------------------------------------------------------------------------------------------------------------------------------------------------------------------TTH---------------------IVLPIAS--------------------KQSE-SSLMMTAV-PESPYK--------------------------------------------------------------------TLTVSYTPISS-------------------------------PNNNRSSPST-HAISN----------------------------------PSNS--------LASQ----NTFT----------------SPSIVHMKALV----------SDSNAS-----------------------------------------------------NGCYVSTVPV------------------------YV-------------------------GSISEA-------------------KPS---------------SATLA-------------------GFYT-HQLKRNISPEP----------------VKELPLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- isotig03405___ORF_2__frame_1__translation -M------------------------------------------------------------IQLFW---------------------IVLNLIFIKIERITMLDSVT---------TVA---SNAGPIKTPTHRK-------INKLMMEKRRRTRINNCLSELKTLVLKALKKD---------------------------------------------------------------------------------------------------------GEQFSKLEKVDILEMTVKYLRFLHQQQQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGGKYRVPL-DVSAEVMRYMNS-----E---EARSRLTDH-ISKCVRVS-NGSPTQHIIP----------------------------------------TSTQT-----------PTPTA---------AHQ--------------------------QINT------------PQTSEQ--HIR-QS----------------------------------------QPQTAPLGDN------------------------------------------------------------------------------------------------------------------------------------------------------------------TTH---------------------IVLPIAS--------------------KQSE-NSLMMAAV-PETPYK--------------------------------------------------------------------TLTVSYTAINS-------------------------------PVS--SSPST-HVINT----------------------------------PVNS--------LTAITSP-NTIT----------------SPSIVHMKALV----------SDSNAS-----------------------------------------------------NGCYVSTVPV------------------------YV-------------------------GSISEA-------------------KPT---------------SATLA-------------------GFYT-QPLKRNCSPEP----------------IKELPLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- CAE1151621.1_HES1__Sepia_pharaonis_ -MEGFGLGSWRRGEGRRAGRAAATRQPFTHLLLSPYSLFFLSVSGHTRLPNASV--RMCG--KKLAWESGRSPLHTQL------AGSARVPKEVFFSFDNITMLDSVT---------TAA---SNAGPIKTPTHRK-------INKLMMEKRRRTRINNCLSELKTLVLKALKKD---------------------------------------------------------------------------------------------------------GEQFSKLEKVDILEMTVKYLRFLHQQQQV--------------------------------------------------------------------------------------------------------------------------------------------------N-------------ITTDS-LGGKYRVPL-DVSAEVMRYMNS-----E---EARSRLTDH-ISKCVRVS-NGSPTQPIAP----------------------------------------PNTQT-----------PTPTT---------THQ--------------------------QIPT------------PQTSE---HIR-QS----------------------------------------QPQATPLGDN------------------------------------------------------------------------------------------------------------------------------------------------------------------TTH---------------------IVLPIAS--------------------KQSE-SSLMMATV-PETPYK--------------------------------------------------------------------TLTVSYTAINS-------------------------------PVS-SSSPPT-HVINA----------------------------------PINS--------LAAITTP-NTIT----------------SPSIVHMKALV----------SDSNAS-----------------------------------------------------NGCYVSTVPV------------------------YV-------------------------GSISEA-------------------KPT---------------SATLA-------------------GFYT-QPLKRNSSPEP----------------IKELPLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- isotig25066___ORF_15__frame_3__translation ----------------------------------------------------------------------------------------------------------MA---------------EKSNPPTKAQSRK-------NNKPQMEKMRRAKINFFLGQLSTLLSEWRKKD---------------------------------------------------------------------------------------------------------CTRHSKLEKADILEMTVRYVKELQNKHSM------------------------------------------------------------------------------------------------------------------------------------------------EIR-------------NADSK-MHSRYRTGYAECAKEITRYLSSSQNIDV---SVRNRINNH-LARSISMI-DNIQQDVKPVPYLESPEY--------NSP---------DNAVQKT-----EQMEQE-------LPAPVASPIPSPA--IIPTRTPP--------------------AALQINIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- CAE1303503.1_HES1__Sepia_pharaonis_ -M------------------------------------------------------------------------------------------------------AEKL---------------KIPQDTKISLTRK-------GNKPLMEKRRRARINHHLDQLAGLLSEGRKKD---------------------------------------------------------------------------------------------------------STRHSKLEKADILEMTVKYVKDLQNQLNM------------------------------------------------------------------------------------------------------------------------------------------------QSI-------------TADPN-MHSKYRIGYKECASEVTRYLSSAQSIDE---GVRNRITDH-LANSINVTRTNRPQGSKPVSRVENIEKK------DNTS---------EITVQKT-----EVSKQE-------LPAPATRTTAS------PTANPM--------------------KSLQVNIPNS--------LPLSGITI-PVLAPGSETL--LSPQTAAISLCDNSLHPDSLTV---PENSRLQSTATTAPNLGKTQEKSTPKAAMEISQNRRHYFHQSKQTVSVQPFLTTNTPAV--------KVSAPSTRLTDKKT------------------------------------------------------------------TTVTEPL----------------LVKLSPSQVA-GSF---------------------QIIPGSI--------------------YSGQPVALYLAPTATIPT----------------------------------------------------------------------VPEHVTSSSTNALP---------------------------RPAITAASTTNSDSLSI----------------------------HMPQVVTAVVSPPTLGLLSPQAATPAPTSLPGSTCFSHVSSS-----------------------LPLSASVSTS-------------------------------------------SYNPSLFAPTSGQVAYPQ------------------------RLETGNH-----------------------------------------SSSLHANH------------------------------------------------------------------LCSSENEQSLWR---------PCFLCISNNLSFLLSFFSFIFFLSFLLSFFS----FIFFLSFLFSFFS----FIFLFFFFLFLFFFFFFYLSFLFIFLFFYLFLFFFYLFLFIFFFSFIFLFFYLSFFLSFFFSFIFLFLLSFFS---FLSFIFLFCLVFLSFLSCLSLII----IQ isotig08530___ORF_2__frame_1__translation -MS--------------------------------------------------------------------------------------------------TMHSEKI---------------STATSTSSSENRK-------SSKPIMEKRRRARMNASLAELKSLLLEVMKKD---------------------------------------------------------------------------------------------------------GNRHSKMEKADILEMTAKHLRHLQRQHFT------------------------------------------------------------------------------------------------------------------------------------------------VPT-------------TKEESPFLTKYTLGFQECTSEVSRYLSSVAEVDT---EIRARLLNH-LATYISQPSTPSSSVSSTASSPTSTTSTTIIPTPISRPSS-----VTDTSPRQS-----PASLAS-------PSSPSASSTPQ---LVSPSQTAPPPPP----------------AQIQLQLT-----------PSLAPS--VSSLQSSQ----ISVSTAQ-----TTTRPE--------SMVAPKQITLFPADFCTATTTP-----------------------TATTFTAPAT--------------GGILSLDTS------------------------------------------------------------------------CPQ-------------------IQTAKLL-SGV---------------------QLITTRL--------------------PNGQ-MAFVLPTN-LMTETQQQQ-----------------QQQQPPQPQQQPQPQQQQ----------------------------RQQSQQSYIPIPVYAP----------------------TSSAISPLTPTVGGAP-GVMAL-----------------------------LPQV-------------SKTGVTPTASMAFMPHLFPIPQMTG---INSSISHLPLI--------TAETTESATT------------------------------GAVTG-----------SVTSAGTGTGLTLPL------------------------KLSPSVT-------------------ETNHQVSL---------------PELTKKL-------------ASTPLTQAQ-----------------TTAKREENNVVEPAP------------VLQQIEEDNVWR---------PWAH--------------------------------------------------------------------------------------------------------------------------------------------------------- CAE1315748.1_HES1__Sepia_pharaonis_ ----------------------------------------------------------------------------------------------------------------------------------------------------MEKRRRARMNASLAELKSLLLEVMKKD---------------------------------------------------------------------------------------------------------GNRHSKMEKADILEMTVKHLRHLQRQHFT------------------------------------------------------------------------------------------------------------------------------------------------VPT-------------TKEESPFLTKYTLGFQECTSEVSRYLSSVTEVDA---DVRARLLTH-LSTYINQS-SSSSTVSSTATSPTSTTSANAINAPVSRPSS-----VTDTSPRQS-----PVSIKT-------PPSPSATPTSS--QHVAPSQAPAPPPP----------------AQIQLQLT-----------PSLAQS--ASTVQCSQ----ISVSTAQ-----STTRPE--------SMVAPKQITIFPADFCTATTTT-----------------------TAATLTAPAA--------------GGILSLDTS------------------------------------------------------------------------CPQ-------------------VQSAKLL-SGV---------------------QFITTRL--------------------PNGQ-MAFVLPTN-LMTETQQSQ-----------------QQQQQQQQQQQQQQQQQQQQQQQQQQQQ-----------------PRQQSQQSYIPIPVYAP----------------------TSPAISPLATTVSGAP-GVMAL-----------------------------LPQV-------------SKTGVTPTTSMAFMPHLFSLPQMTG---VNSSIPHLPLI--------RADTNEAATA------------------------------GTVAG---------------TVAGTGLTVPV------------------------KLSPSIT-------------------EINPPVLL---------------PELTKKL-------------ASTPATQQQ-----------------TPAKREENNVAGPAP------------VLQQIEEVSLLSVPP------PFPPP-------------LSFCLSIYLSIYL-----SIYLSIYLSNF---------------------------------------------------------LCFFLTYSSAQTHNFVLSYEAKT------------------------------ XP_025083276.1_transcription_factor_HES_1_A_like__Pomacea_canaliculata_ -M------------------------------------------------------------------------------------------------------ADTA---------------VASPMKIDLNNRK-------NKKPLMEKRRRARINSCLSQLKSLVLQAIKKD---------------------------------------------------------------------------------------------------------SSQFSKLEKADILELTVKHLRALQRQQAA------------------------------------------------------------------------------------------------------------------------------------------------GAM-------------TSDPS-VVSKYRAGFNECAKEVIRYMSSVRDVSD---EIKDRVVGH-LAGCLQVV-NHMTPPHSEAMAA-------------------------------------------------------------------PHPHCL--------------------KPLHVHI------------PQQQPL--TAAMPAPA----LLVPQGV-----LPAALS--------LTPSSISSTSSSPPLSSSPGTQ-----------------------TLSPVTAVSLPAA--------IQTAATMVPSST------------------------------------------------------------------------ATT----------------SHTGLPGHIS-GAF---------------------KIVPSSS-------------------CPAGA-VALYLGGP-SAGG-------------------------RTGDLGVDAVPVY-----------------------------SLPLPQVDGAVTAFVPP------------------VTSAQAIPAHHVTSHQLTHV----------------------------------------------------TNTLSSSVKQEYLSCA--------------------------------VDLRQHS------------------------------------------------KVMKPISMDVDRSPLPV----------------------SLGHCTQ------------------------------------------ASLSDE---------------------------------------------------------------------------KLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- AMB73113.1_Hes_B__Crepidula_fornicata_ -M------------------------------------------------------------------------------------------------------AETM---------------IASSVKSEHSTRK-------NKKPLMEKRRRARINSCLSQLKSLVLQAIKKD---------------------------------------------------------------------------------------------------------SSQFSKLEKADILELTVKHLRALQRQQAA------------------------------------------------------------------------------------------------------------------------------------------------GAM-------------SQDTT-VVSKYRAGFNECAKEVVRYMGSVREVNT---DVKERVVGH-LANCLQVV-NQITPMESL-----------------------------------------------------------------------QHQQPM--------------------KPLHVQI------------PQQAMN--TASVAPSV----IMHTAAA-----ASSQLG--------YVPVSRSSVSAHQEVSISAT----------------------------PLSALPL------------QSAAAM---TT------------------------------------------------------------------------APT----------------TVSPAPTRIS-GAF---------------------KIVPS----------------------SSGA-VALYLGGA-NSVNVP-----------------------RSEAVSVDAVPLY-----------------------------SVSLPQNDNATAFVTPP-------------------------PTSHVTSSHIESQ----------------------------------------------------RYQAVSPVKGDYTPIAPASLP---------------------------VDLRQTH---------------------------------------------------KMSFDSSVYSPL------------------------SVGQCSP------------------------------------------ASLSDE---------------------------------------------------------------------------KLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_021363795.1_transcription_factor_HES_1_like__Mizuhopecten_yessoensis_ -M--------------------------------------------------------------------------------------------------DIQQDYDT---------------MSLKSEEKYSQRK-------SKKPLMEKRRRARINSCLLQLKSLVLQAMKKD---------------------------------------------------------------------------------------------------------TSHYSKLEKADILEMTVKHLRALQRRQIT------------------------------------------------------------------------------------------------------------------------------------------------SAV-------------AADPT-VAAKYNIGFSECASEVMRYLGSAQGINE---DVRNRVVNH-LGGCVQTV-NASSMAHHNL------------------------------------------------------------------------------------------------QPIHVQI------------PASQNA--VNNARAMY----------------SSERLL--------VQSASQQQNGCSFPLQTSIP--------------------------------------------------------------------------------------------------------------------------------------------------------VQTPPNG-GQF---------------------ELVPGSA--------------------FSGP-VAFCMAPSEDMST----------------------------------------------------------------------MSNIYTTNSLKSEP----------------------RAVSTSPE--SHKSDY-HRLQE----------------------------------------------QEMYRSPEKHAH------------------------------------TNSHAVS----------------------------------------------------TLSSSPVYSPA------------------------T------------------------------------------------SALKEE---------------------------------------------------------------------------QLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022341485.1_transcription_factor_HES_1_B_like__Crassostrea_virginica_ -MC--------------------------------------------------------------NTNLTNTQ--------------------------TNMEDYEQE---------------NRNFPEDKILSRK-------SKKPLMEKRRRARINNCLVQLKSLVLQAMKKD---------------------------------------------------------------------------------------------------------TTHYSKLEKADILEMTVKYLRSLQRRQMT------------------------------------------------------------------------------------------------------------------------------------------------SAV-------------AADPT-IAAKYSMGFTECASEVARYLGNSQGIND---EVRGRLLGH-LSNCVQTG-NSSQQSVNGQTYV---------------------------------------------------------------------------------------------QPLHVQI------------PRVQGD--LSRVHSEG-----------------------------------LLSQPPAGFLTNSSS--------------------------------------------------------------------------------------------------------------------------------------------------------SSGVQVS-GSF---------------------QIVPDNL--------------------YVEH-LPVFLRQS----------------------------------------------------------------------------------------------------------------QTMMESVSSRHTSLR----------------------------------------------------KPTPYSPSPCDMSRD-----------------------------------------------------------------------------------------LYQSSKVGLVPSPP------------------------------------------------------------------------VPSAAMTL-----------------------------------------------------------------------KEERLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_011456335.2_transcription_factor_HES_1__Crassostrea_gigas_ -MC--------------------------------------------------------------NTYQSNTQS-------------------------NNMEDYEQE---------------NRNFPEDKILSRK-------SKKPLMEKRRRARINNCLVQLKSLVLQAMKKD---------------------------------------------------------------------------------------------------------TTHYSKLEKADILEMTVKYLRSLQRRQMT------------------------------------------------------------------------------------------------------------------------------------------------SAV-------------AADPT-VAAKYSMGFTECASEVARYLGNSQGIND---EVRGRLLGH-LSNCVQTG-NSFTASGRR-------------------------------------------------------------------------------------------------ADLRTTI------------ARSD-------------------------------------------------STSPERPVTCSLR--------------------------------------------------------------------------------------------------------------------------------------------------------RTPVPAT-GGV---------------------LI-----K------------------------LYIFIRVT----------------------------------------------------------------------------------------------------------------GDRVLPDSSRQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLQ---------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022286303.1_transcription_factor_HES_4_like__Crassostrea_virginica_ -MPGSIKGSCQ--------------------------------------PQFRYTFKI---TAQADTPHSKIIDN------------------------TNMSVDTLD---------------NVMSKDHKTSLRK-------SNKPIMEKRRRARINHCLTQLKSLVLESMRKD---------------------------------------------------------------------------------------------------------SSQYSKLEKADILEMTVKHLRNLQRNQLA------------------------------------------------------------------------------------------------------------------------------------------------SAM-------------ASDPT-VVTKFRAGFHECANEVMRYLGTVQNVGP---DVKSRLVSH-LSTCLQTS-NNTPSSDNVHTPVPS---------------------------------CPPPQQVP-------VTSP-------------QQVNIL--------------------QPLSVHI------------PHNANV--PSRPQSSE----------------FVYSRQ--------TSPPSQTQSPQLLNIAAPVKSEC----------------------------------------------------NNN---------------------------------------------------------------------HITSP--------------------IKSTPIS-GQF---------------------QIIPSNL--------------------YNGP-VAVYVGQF----------------------------------------------------------------------------NQRQSATSPDAMP----------------VFTLQVPANNISPSFHNNSSPQ-------------------------------------------------DFSQQQKSKPFAQHH------------------------------------QQQHRSA--------------------------------------------------FVECKQGVPEASD----------------------------------------------------------------------------------------------------------------------------------------------------------NLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_011456334.2_transcription_factor_HES_4_A__Crassostrea_gigas_ -M---------------------------------------------------------------------------------------------------MSVDTLD---------------NVMSKEHKTSLRK-------SNKPIMEKRRRARINNCLTQLKSLVLESMRKD---------------------------------------------------------------------------------------------------------SSQYSKLEKADILEMTVKHLRNLQRNQLA------------------------------------------------------------------------------------------------------------------------------------------------SAM-------------ASDPT-VVTKFRAGFHECANEVIRYLGTVQNVGS---DVKSRLVSH-LSTCLQTQ-NNTASTENMHTP------------------------------------CQPQQQVP-------VTSPQ------------QQVNIL--------------------QPLSVHI------------PHNANV--ASRPQSSE----------------FAFSRQ--------TSPQSLSQSPQLLNIATPVSSDS----------------------------------------------------NSN------------------------------------------------------------------------SP--------------------IKSTPIS-GQF---------------------QIIPSNL--------------------YNGP-VAVYVGQI----------------------------------------------------------------------------NQRQCMTTPDSMP----------------VFTLQVPANNTSPSYQCR-SPQ-------------------------------------------------EFPQQQKSKPLA----------------------------------------QQHRSA--------------------------------------------------FVECKQGVPESPE----------------------------------------------------------------------------------------------------------------------------------------------------------SLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- Q9HCC6.1_RecName__Full=Transcription_factor_HES_4___Homo_sapiens_ -MA-------------------------------------------------------------ADTPGKPSASPM-----------------------AGAPASASR---------------TPDKPRSAAEHRK-------SSKPVMEKRRRARINESLAQLKTLILDALRKE---------------------------------------------------------------------------------------------------------SSRHSKLEKADILEMTVRHLRSLRRVQVT------------------------------------------------------------------------------------------------------------------------------------------------AAL-------------SADPA-VLGKYRAGFHECLAEVNRFLAGCEGVPA---DVRSRLLGH-LAACLRQL-GPSRRPASLSPAA----------------------------------------------------------------------------------------------------------------PAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APAPEVY-AGR---------------------PLLPS----------------------LGGP-FPLLAPPL--------------------------------------------------------------------------------------------------------------------LPGLTR----------------------------------------------------------ALPAAPR-------------------------------------------------------------------------------------------------------AGPQGPG----------------------------------------------------------------------------------------------------------------------------------------------------------GPWR---------PWLR--------------------------------------------------------------------------------------------------------------------------------------------------------- AAD43304.1_basic_helix_loop_helix_transcription_factor_hairy2__Xenopus_laevis_ -MP-------------------------------------------------------------ADTMEKPTASPI-----------------------AGAPANSAQ---------------TPDKPKSASEHRK-------SSKPIMEKRRRARINESLGQLKTLILDALKKD---------------------------------------------------------------------------------------------------------SSRHSKLEKADILEMTVKHLRNLQRVQMT------------------------------------------------------------------------------------------------------------------------------------------------AAL-------------TSDPS-VLGKYRAGFNECTNEVTRFLSTCEGVNT---EVRTRLLGH-LSSCLGQI-VAMNYQQ-----------------------------------------------------------P---------------PSSQ--------------------QPLHVQL------------PSSTPA----PMPIS----------------------------------CKVNPAE------------------------------------------------------------------------------------------------------------------------------------------------------------------AISPKVFQGGF---------------------QLVPA----------------------TDGQ-FAFLIPNP-AYTSS----------------------------------------------------------------------------------P------------------------GPVIPLYANVTSPG----------------------------------------------------GRQSQSPVQGLTTFG------------------------------------------------------------------------------------------HKMPHMAQAVSPL------------------------GGST---------------------------------------------GADSAE---------------------------------------------------------------------------SVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- NP_571154.2_hairy_related_6__Danio_rerio_ -MP-------------------------------------------------------------ADIMEKNSSSPV-----------------------AATPASMNT---------------TPDKPKTASEHRK-------SSKPIMEKRRRARINESLGQLKTLILDALKKD---------------------------------------------------------------------------------------------------------SSRHSKLEKADILEMTVKHLRNMQRAQMT------------------------------------------------------------------------------------------------------------------------------------------------AAL-------------NTDPT-VLGKYRAGFSECMNEVTRFLSTCEGVNT---EVRTRLLGH-LASCMTQI-NAMNYPTQHQI-------------------------------------------------------P----------AGPPHPSFS--------------------QPM-VQI------------PSATQQ--ANVVPLSG-------------------------------VPCKSGSSSNLT---------------------------------------------------------------------------------------------------------------------------------------------------------------SDATKVY-GGF---------------------QLVPA----------------------TDGQ-FAFLIPNA-AFAP-----------------------------------------------------------------------------------------------------------NGPVIPVYAN-----------------------------------------------------------NSNTPV-------------------------------------------------------------------------------------------------------PVAVSPG------------------------A------------------------------------------------PSVTSD---------------------------------------------------------------------------SVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- NP_001081396.1_transcription_factor_HES_1_A__Xenopus_laevis_ -MP-------------------------------------------------------------ADVMEKNSSSPV-----------------------AATPASVSN---------------TPDKPKTASEHRK-------SSKPIMEKRRRARINESLGQLKTLILDALKKD---------------------------------------------------------------------------------------------------------SSRHSKLEKADILEMTVKHLRNLQRVQMS------------------------------------------------------------------------------------------------------------------------------------------------AAL-------------STDPS-VLGKYRAGFSECMNEVTRFLSTCEGVNT---DVRTRLLGH-LANCMNQI-NGMNYPTQPQM-------------------------------------------------------PS---------AAAPHPAYG--------------------QPM-VQL------------PGAAPQ--SSPAPIA----------------------------------CKMGGPP------------------------------------------------------------------------------------------------------------------------------------------------------------------VEAAKVY-GGF---------------------QLVPA----------------------PDGQ-FAFLITNP-AFPH-----------------------------------------------------------------------------------------------------------NGSVIPVYTN----------------------------------------------------------SNVGTAL-------------------------------------------------------------------------------------------------------PPSVSPS------------------------VM-----------------------------------------------PSVTID---------------------------------------------------------------------------SVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- Q14469.1_RecName__Full=Transcription_factor_HES_1__Homo_sapiens_ -MP-------------------------------------------------------------ADIMEKNSSSPV-----------------------AATPASVNT---------------TPDKPKTASEHRK-------SSKPIMEKRRRARINESLSQLKTLILDALKKD---------------------------------------------------------------------------------------------------------SSRHSKLEKADILEMTVKHLRNLQRAQMT------------------------------------------------------------------------------------------------------------------------------------------------AAL-------------STDPS-VLGKYRAGFSECMNEVTRFLSTCEGVNT---EVRTRLLGH-LANCMTQI-NAMTYPGQPHPALQA-----------------------------------PPPPPP---------GP----------GGPQHAPFA-PP-----------------PPL-VPI------------PGGAAP------PPGG-------------------------------APCKLGSQA------------------------------------------------------------------------------------------------------------------------------------------------------------------GEAAKVF-GGF---------------------QVVPA----------------------PDGQ-FAFLIPNG-AFAH-----------------------------------------------------------------------------------------------------------SGPVIPVYTS-----------------------------------------------------------NSGTSV------------------------------------------------------------------------------------------------------GPNAVSPS------------------------SG-----------------------------------------------PSLTAD---------------------------------------------------------------------------SMWR---------PWRN--------------------------------------------------------------------------------------------------------------------------------------------------------- P35428.1_RecName__Full=Transcription_factor_HES_1___Mus_musculus_ -MP-------------------------------------------------------------ADIMEKNSSSPV-----------------------AATPASVNT---------------TPDKPKTASEHRK-------SSKPIMEKRRRARINESLSQLKTLILDALKKD---------------------------------------------------------------------------------------------------------SSRHSKLEKADILEMTVKHLRNLQRAQMT------------------------------------------------------------------------------------------------------------------------------------------------AAL-------------STDPS-VLGKYRAGFSECMNEVTRFLSTCEGVNT---EVRTRLLGH-LANCMTQI-NAMTYPGQAHPALQA-----------------------------------PPPPPP--------SGP----------AGPQHAPFAPPP-----------------PPL-VPI------------PGGAAP------PPGS-------------------------------APCKLGSQA------------------------------------------------------------------------------------------------------------------------------------------------------------------GEAAKVF-GGF---------------------QVVPA----------------------PDGQ-FAFLIPNG-AFAH-----------------------------------------------------------------------------------------------------------SGPVIPVYTS-----------------------------------------------------------NSGTSV------------------------------------------------------------------------------------------------------GPNAVSPS------------------------SG-----------------------------------------------SSLTSD---------------------------------------------------------------------------SMWR---------PWRN--------------------------------------------------------------------------------------------------------------------------------------------------------- Q26263.2_RecName__Full=Protein_deadpan__Drosophila_melanogaster_ -MDYKNDIN-----------------------------------------------------SDDDFDCSNGYS-------------------------DSYGSNGRM---------------SNPNGLSKAELRK-------TNKPIMEKRRRARINHCLNELKSLILEAMKKD---------------------------------------------------------------------------------------------------------PARHTKLEKADILEMTVKHLQSVQRQQLN------------------------------------------------------------------------------------------------------------------------------------------------MAI-------------QSDPS-VVQKFKTGFVECAEEVNRYVSQMDGIDT---GVRQRLSAH-LNQCANSL-EQIGSMSNFSNGYRG--------------------------------GLFPATAVT--------AAP---------------------------------------TPLFPSL------------PQDLNN--NSRTESSA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAIQMGGL---------------------QLIPSRL--------------------PSGE-FALIMPNTGSAAPPPGPF----------------------------AWPGSAA---------------------------GVAAGTASAALASIANP------T-----HLNDYTQSFRMSAFSKPVNTSVPANLPENLIH----------------------------TLPGQTQLPVK-----NSTSPPLSPISSISSHCE---------------------------------ESRAAS--------------------------------------------PTVDVMSKHSFAGVFSTPPPT----------------------SAETSFN--------------------TSGSLNL---------------SAGSHDSSGCS--------RPLAHLQQQQVS------STSGIAKRDREAEAESSDCSLDEPSSK------KFLAGAIEKSSSAWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_013775914.1_transcription_factor_HES_4_A_like__Limulus_polyphemus_ -MP------------------------------------------------------------------------------------------------------------------------SEKSSMKTSENRR-------STKPIMEKRRRARINNSLGELKNLILDALKKD---------------------------------------------------------------------------------------------------------NARHSKLEKADILEMTVKHLQNLQRQQIT------------------------------------------------------------------------------------------------------------------------------------------------ACS-------------LSDPS-AMSKFRAGFNECANEVSRYLSGMKGIDL---SVRQRLMNH-LADCLSGL-SPTYPQTSGNYSL-----------------------------------------------------PSL-------------------------------------SPVHIQV------------PASTTT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDTKLF-EGI---------------------QLVPTRL--------------------QNGE-IAFLLPGE-GLTNQNHL---------------------------------------------------------------------------STYSP--------------------VMSSIPSGPVSVLGSSGILSPAAS--------------------------------------------DRSLSSPSPVTYTSTTS------------------------------------------------------------------------------------------PVLITSGPVFEPI------------------------SPA----------------------------------------------PFHQQEK----------------------------------------------------------------------PETEHVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022247725.1_transcription_factor_HES_1_B_like_isoform_X2__Limulus_polyphemus_ -MP------------------------------------------------------------------------------------------------------------------------ADKSYSKTSDYRR-------ATKPLMEKRRRARINQCLNELKTLVLDALHED---------------------------------------------------------------------------------------------------------PSRHSKLEKADILDMSVRYLQNIQRQQVA------------------------------------------------------------------------------------------------------------------------------------------------AAI-------------ATDPA-VFNKFKAGFNECAAEVRRYVSQIE-IDY---NLRQRLLSH-LGNTIARL-ATPTTACTC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- XP_013395728.1_transcription_factor_HES_4_B__Lingula_anatina_ -M------------------------------------------------------------------------------------------------------AEKG---------------STLLSSSASHARR-------TNKPLMEKRRRQRINECLTELKALVLQAMQRD---------------------------------------------------------------------------------------------------------TSRYSKLEKADILEMTVKHLRSIQRQQMA------------------------------------------------------------------------------------------------------------------------------------------------AAV-------------TSDPS-VLGKYRAGFNECANEVTRYMRSIDGINE---DVRLHLLNH-LASCAYKV-NQVTPSETSSSAST------------------------------------VQQTIT---------APQTIAAPQ-----QPQPQTL--------------------QPIHVQI------------PSASQF--TTVTTPSM-------------------------------LPCQPQQTQQQPTVSCPQNG-------------------------------------------------------------------------------------------------------------------------------------------------------LVQSNIT-GSF---------------------QLIPGTL--------------------PNGQ-VAYILQSP-SQIQNGQL---------------------LQQQ-------------------------------------------------SNVISP---------------------VNNVTAMPIVLQTSPNV-QQQQG--------------------------------------------QQQLQTTSPTVLNI------------------------------------PTMHQLS----------------------------------------------PAQQQKQTTVESGLAPLTNF--------------------CKVDGNNNGH----------------------------------------SFVNAEL----------------------------------------------------------------------NRNDRMWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- P14003.2_RecName__Full=Protein_hairy__Drosophila_melanogaster_ -MV-------------------------------------------------------------TGVTAANM---------------------------TNVLGTAVVP--------------AQLKETPLKSDRR-------SNKPIMEKRRRARINNCLNELKTLILDATKKD---------------------------------------------------------------------------------------------------------PARHSKLEKADILEKTVKHLQELQRQQAA------------------------------------------------------------------------------------------------------------------------------------------------MQQ-------------AADPK-IVNKFKAGFADCVNEVSRF----PGIEP---AQRRRLLQH-LSNCINGV-KTELHQQQRQQQQ---------------------------------------------------------------------------------------------QSIHAQMLPS--------PPSSPEQ--DSQQGAAA---------------------------------------PYLFGIQQTASGYF-------------------------------------------------------------------------------------------------------------------------------LP----------------------------NGM---------------------QVIPTKL--------------------PNGS-IALVLPQSLPQQQQQQL---------------------LQHQQQQQQLAVAAA---------------------------AAAAAAAQQQPMLVSMP---------------------QRTASTGSASSHSSAGYESAPGS--------------------------------------------SSSCSYAPPSPANSSYE------------------------------------------------------------------------------------PMDIKPSVIQRVPMEQQPL------------------------------------------------------------------------SLVIKKQI----------------------------------------------------------------------KEEEQPWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022335999.1_protein_deadpan_like__Crassostrea_virginica_ -ME-----------------------------------------------------------------------------------------------------GSEK---------------SPDVTSTASETRK-------NSKPVMEKKRRARINASLAELKSLLLDVMKAE---------------------------------------------------------------------------------------------------------GTRQNKMEKADILEMTVRHLRQLQRQQFS------------------------------------------------------------------------------------------------------------------------------------------------AMS-------------ATDPA-VINKYRLGFNECASEVSKYLSNVDGLNA---EFRARLLNH-LANVTTNV-EQPEENKDISPKAS------------------------------------PVNRVAY-----HAPYPKVNSTNL----NIVQSNAG--------------------QILKVNGS-----------PVSVAN--SNMVTADV-----------------------------------MQNLEKNNNISQKLDNF----------------------------------------------------VVNN------------------------------------------------------------------------EP--------------------NVSSKVI-HGV---------------------QTFPTQM--------------------QSGE-VAFIIPAA-NMVQYGTI-------------------------------PNY-----------------------------VIPVLQPQGAIQISNSP------------------NNVIQAQHTVPIAYSGCTTSSHSVVT---------------------------SVVPNTTFINST-------QNTVSLPVSLVTSENGGFT-----------------------------VQQREQS--------------------------------PQFTSF------PVNSISTQATHIQKLVLPS-----------------------NNINNNNNNNN-----------NSNKEVRDEDSTLR---------SRRISPSVESRST-----------------------------------------------------------------PRELEKLDPMWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_014772623.1_PREDICTED__protein_deadpan_like__Octopus_bimaculoides_ -MH------------------------------------------------------------------------------------------------------------------------SEKLSSTTGEGRK-------SSKPIMEKRRRARMNASLAELKALLLEVMKKE---------------------------------------------------------------------------------------------------------GARHSKMEKADILEMTVKHVRQLQRQHFS------------------------------------------------------------------------------------------------------------------------------------------------VSA-------------NEDPT-IINKYRLGFNECATEVSRYLNSVDEVNI---EVRARLLNH-LACYMTNY-GSSSTPNSSISSSSS-----------------------------------VSESSSCLSPNIPTLSPKSASTPQ---ISIPKAQSS--------------------SPVVLTV------------AAAAPS--VPTPPSKP----IVLTTEA-----CTTTPV--------ASLAAASSTTTTTSIGTCTSST-----------------------NTTTISNTL---------------NGSLSFTSN------------------------------------------------------------------------SP--------------------LQTAKFV-SGV---------------------QLIPTKL--------------------PSGE-VALVFPAN-VMAGTQTQ------------------------------------------------------------------QPSYIIPIYASTPP-------------------------AVSPLTTTVSSTP-SVMAF-----------------------------LPQVATSGL--------KTCAVTPIQNTSNISQVLSNATNP-----------------------QITTTTVV--------------------------------PSLSD---------HLQICSEPNISSISLPS------------------------KMSPPFP--------------------SSKVTTF---------------PSLSEH--------------PIYNLDNNN--NNNNNITTTTTNTTTTTATNNNNNNNNNNPVA------LEPLVMQHISEENVWR---------PWAY--------------------------------------------------------------------------------------------------------------------------------------------------------- XP_035828630.1_probable_serine/threonine_protein_kinase_tsuA__Aplysia_californica_ -MM----------------------------------------------------------------TESDLVSP------------------------TSTSAPHEL---------------SPGRMEEKTSYRK-------SNKPMMEKKRRARINSCLGQLKSLVLQAMKKD---------------------------------------------------------------------------------------------------------NSQYSKLEKADILELTVKHLKNVQRYQVS------------------------------------------------------------------------------------------------------------------------------------------------SSL-------------TQTPD-AISKYRAGFNECANEVIRYLGQSHGVND---EARSRILSH-LASILTPI-NTLPLQQAHHHTPI-----------LPAPSS-----S------------VVAASQQ------QQLQQQLQQQHH---FHLQQQQQQHQQHAAYL--------SAASQGLTLDSNNN--------NSSSNNN--NNNNSSNINSKSIKLETSS-----YATHSS--------AVVKSVGREATAMNLATPTPDVT--------------------SANSASPTAFQ---------------APIVSGVTA------------------------------------------------------------------------APPG------------GLQLPCIATAAMA-TGTQ-------------------FQLVPSAL--------------------PSGQ-LALVLAPQHVSALNMGV---------------------YTQQQQQQQQAAA-----------------------------ATRTPLLHDAAQSLPPPPPPPPA-------PHSQNQKVTTAGTRIPLLHDTTSTMHRLHQHHHHQQQHH------------QQQQQQQQQHPHSSVLEDGK-NRLPSNLRNESPMSLVTKHPRSPKLTGTP-----PTTTAVQPSP---------LQHQEVSQG-----------------------------GGQGERS-------AAVEQSTAARATVTTSPN------------------------HVTSHQA------------------------------------------SSASSRDSGKK---------TETDMDTDD--NDNSNIHRNIINKNTTANNNNSNNNNNNNKNNA----NNNVMRGTTKENDPMWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- Q00P32.2_RecName__Full=Transcription_factor_HES_2___Xenopus_laevis_ -MAPNVALA------------------------------------------------------------------------------------------DSMHNYQPK---------------PGKRNQEASELRK-------TLKPLMEKRRRARINESLNQLKTLILPLIGKD---------------------------------------------------------------------------------------------------------NSRYSKLEKADILEMTVRFLRDIPPVQAQ-----------------------------------------------------------------------------------------------------------------------------------------------N----------------------QADRYKEGYRACVERLSAILGKSHVLTG---EASNRLLEY-LQRSPELC-SSDCNHPPKPQR-----------------------------------------------------------------------------------------------------------------PRIVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVSPRTS---------------------------------------------------------------------------------------------------------------------QFGSP-------------------------LQNQPSSHRPAPC------------------------------------------------------------------------------------------------------------------------------------------------------------------------PP------------------------------------------------------------------------------------------------------------------------------------------------------QLNSSIWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- O54792.2_RecName__Full=Transcription_factor_HES_2___Mus_musculus_ -MR------------------------------------------------------------------------------------------------------------------------LPRRVEDAAELRK-------NLKPLLEKRRRARINESLSQLKGLVLPLLGAE---------------------------------------------------------------------------------------------------------TSRSSKLEKADILEMTVRFLQE---QPAT------------------------------------------------------------------------------------------------------------------------------------------------LYS-------------SAAPG-PLNSYLEGYRACLARLARVLPACSVLEP---AVSARLLEH-LRQRTVSD-DS---------------------------------------------------------------------------------------------------------------------------PSLTLP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAPAPAPSPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------VPP------------------------------------------------------------------------------------------------------------------------------------------------------PGSSGLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- Q9Y543.1_RecName__Full=Transcription_factor_HES_2___Homo_sapiens_ -MG------------------------------------------------------------------------------------------------------------------------LPRRAGDAAELRK-------SLKPLLEKRRRARINQSLSQLKGLILPLLGRE---------------------------------------------------------------------------------------------------------NSNCSKLEKADVLEMTVRFLQEL---PAS------------------------------------------------------------------------------------------------------------------------------------------------SWP-------------TAAPL-PCDSYREGYSACVARLARVLPACRVLEP---AVSARLLEH-LWRRAASA-TLDGGRAGDSSG-----------------------------------------------------------------------------------------------------------------PSAPAP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APASAP---------------------------EPASAPVPSPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------SPP-------------------------------------------------------------------------------------------------------------------------------------------------------CGPGLWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- CAE1315754.1_HES1__Sepia_pharaonis_ -MH-----------------------------------------------------------------------------------------------------SEKV---------------STATSTSSSENRK-------SSKPIMEKRRRARINASLAELKSLLLEVMKNE---------------------------------------------------------------------------------------------------------GNRHSKMEKADILEMTVKQLRLLQRQHFS------------------------------------------------------------------------------------------------------------------------------------------------ASA-------------NDDSP-VLTKYVLGFQECASEVSRYLSSMAEVDP---EIRTRLLNH-LATYITSS-PSFPNSSSPKRHYSSSSPLPA--ALVNRPTS-------------------ASESSS-------CPSPDKVASS---------------------------------SPL----------------PSRHVF--AAKVPGCPTE--II------------------------TSNDASSSSDSKQTISSATTNVT-------------------------------------------GVTNGILTLDAS-------------------------------------------------------------------------------------------LSHIQTSKM--GNV---------------------QLLATKM--------------------PACQ-VAFVLPAS-VMTDDSQQ----------------------------------------------------------------TLRPQQNYFPVPIYAP---------------------TSQATLMPMTSSGPSTG-AMMTL-----------------------------MPDVTK-----------SGISVAPLTNMSAVPQIISFPGT-----LPSPISSRAQI--------LVNGTDIYKE----------------------------------------------TELTHKNSTRMSSPEMK---------------------QTLSPS--------------------------------------------PSVTKELT-------------------------------------------RNHISANEEP-----------CTLRVCEDENVWR---------PCFLS--SHFLPSLSFFFLSFFLSITISAFFLFLSFSFFLSIFLSFFLSVTISVFILSFFLSLFQLSFFLSLFLCFFLSVTISAFFLSLFQCSFFLSFFLSLFQLSFFLPFFLSFFLSFFLSFFLSSEFYIYLSIYLSIYLSIYLSIYLSIYPKRIL XP_021350063.1_protein_hairy_like_isoform_X2__Mizuhopecten_yessoensis_ -M------------------------------------------------------------------------------------------------------SSDS---------------EMYTPKKDDSLRK-------INKPMMEKKRRARINHCLTQLKSLVLEAMKRD---------------------------------------------------------------------------------------------------------SAQISKLEKADILEMTVNYLRNTQHQQQQ------------------------------------------------------------------------------------------------------------------------------------------------CVD-------------STTDM-RRNKYRTGFNECATEVMRYLGNEEGATP---DVKSRLSDH-LTRCVRVM-NSRLTESRTEGNE------------------------------------------------------------------YNSRTYG--------------------EGLSIDI------------PVSGSN--MGSIPNQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSV---------------------YLLKTQN--------------------ANAT-MSYRGQQS----------------------------------------------------------------------------------------------------------------VYTTGQMTFSESLSHYQINKD---------------------------------------------NSMMNVSPVRQGQ--------------------------------------GNNVT-----------------------------------------------------SGQQHIQHPG------------------------YLNGSMN---------------------SGRST----------------PTGNDNMDQLN------------------------------------------------------------------NNNEAVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_033724611.1_transcription_factor_HES_1_B_like__Pecten_maximus_ -M------------------------------------------------------------------------------------------------------SSDS---------------EMYTPKKDDSLRK-------INKPMMEKKRRARINQCLTQLKSLVLEAMKRD---------------------------------------------------------------------------------------------------------SAQVSKLEKADILEMTVNYLRNTQHQQQQ------------------------------------------------------------------------------------------------------------------------------------------------CVD-------------ATTDM-RRNKYRTGFNECATEVMRYLGNDERVTP---DVKTRVSDH-LTRCVRVM-NSRCAESRLEGSD------------------------------------------------------------------YTSRSYG--------------------EGLSIDI------------PVSGSN--SGSVPNQNN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGV---------------------YLLKTQD--------------------VNGA-MSYHCQQS----------------------------------------------------------------------------------------------------------------LYTNSQRSNSQSRSQYQININ---------------------------------------------NSIMNVSPMRQFQ-------------------------------------EEQNVT-----------------------------------------------------SGQQHFQHPG------------------------HVNGFLD-----------------------RRT----------------PTGNDNLDQI-------------------------------------------------------------------NNNEAVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_012945161.1_protein_hairy__Aplysia_californica_ -MG-----------------------------------------------------------------------------------------------------SPAV---------------AVSPRKSPSSIRR-------ANKPLVEKKRRARINGCLGQLKTLILTAMKTE---------------------------------------------------------------------------------------------------------GAQVSRLEKADILEMTVKYLRHVQSQSVR------------------------------------------------------------------------------------------------------------------------------------------------AVV-------------KLEPE-VAAKFQAGYTECAAEVIRYMDSVTGVTS---DVRSRLESH-LVERLRGS-VSAPAAAAAPTSAGA-------------------------------------------------------------------------------------------AGITAAV------------PMSHSS--MSATRQHN------------------------------QTVRLAPVYAGDAMMGNAMTSH------------------------------------------------------------------------------------------------------------------------------------------------------HAVNHMT-GGS---------------------DESSTHYQ------------------------TAVDLANMAAMVT----------------------------------------------------------------------AKDINAASSSSVQP----------------------LNGGSQCVKQERTSST-SCTFS----------------------------------------------KAQCTSPQKQHHDQMTTFSDQQTDSY---------------------GSRSHSIPS-------------------------------PENVGY-------QGIPTPESAYDDYSPSPS------------------------PVHNKRRRH--------------------------------------TSTSSTESLTFRR--------SPDSEVFTDC-----------------RGGQNDRNNNYVSDPNNNYLSHNYNNDNNNNNNDIVLCR---------------------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022243207.1_protein_deadpan_like__Limulus_polyphemus_ -MP------------------------------------------------------------------------------------------------------------------------AEKPPSKTSDYRR-------ATKPIMEKRRRARINQCLSELKSLILDALNEDLHL---------------------------------------------------------------ISSYT--------------------------------NEVKNPSKSEVMSLIHYEYCYTNEVKNPSKSKVMPLIHYEYCYTNEVKNPSKSEVMPLIHYEYCYTNEVKNPSKSKVMPLIHYEYCYTNEVKNSSKSEVMPLIHYEYCYTNEVKNPSKSEVMPLIHYEYCYTNEVKNPSKSEVMPLIHYEYCYTNEVKNPKWDFQNLIPPFCFSIAAI-------------ATDPT-VLNKFKAGFNECASEVSRYVSRIDGIDN---NLSQRLLNH-LGSCVSSL-QNTTPYNMANTTVM--------------PSV-------------------AFTGIN-------QSFPDIVNQL---------------------------------QPLGVQI------------PTGLFT--SSSTNG--------------------------------VAPRTLQTVAMGIDINNNNNAS---------------------------------------------RAPGPVSNNST--------------------------------------------------------------------------------------------TSASFEKLL-GGL---------------------PLIPSRL--------------------PNGD-IAFLLPSR-CLSSVPGQL-----------------LNSLTLE--------------------------------------SRSSKPLTFSVSRSSTP--TPYCSHSSWDHPKSPAGPSSWDHPTSPPGPRRTASTGSSLSC---------------------------ALSPSVSDSGSD----VFNESLIVSPRKLSPSISRNIKDHLSQQ---DPTSSAHKTGIV------QNIPSTATT--------------------------------SSSNS--------SFVSTAKIGVQSTMEHSG------------------------SLSMEHSFG----------------HISTIASADSF-------LSNRSSQTVAKSWTLVPGHDGVSSKRDHANLQSSS----------------SGANGKIKQASTNVTPQYP---------SSIEQSNETVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- CAE1310672.1_HES1__Sepia_pharaonis_ -M-------------------------------------------------------------------------------------------------------------------------------LFSSFFQ-------SNKPLMERRRRARINNCLTQLKSLLIQDMKKD---------------------------------------------------------------------------------------------------------NSHISKLEKAEILELTVRKLKKLQELINP------------------------------------------------------------------------------------------------------------------------------------------------EDN-------------LAYRE--HPRYRDGFNDCINEVIDYLSKKDCINT---EFRARVINH-LNDSFTNK-GKNLKQEMPNR--------------LNNPDV---------NT--------KQTEPV---------SPAIDCKAL------KGLTFG--------------------HSLSAPI------ESRDGHPRSLCV--LSNQPSSP------------------------------PSVQAVSMDPQMITASHRPVQ----------------------------------------------------------------------------------------------------------------------------------------------------FHTNSHKQRT-QAF--------------------CEISPKHSDP-------NESQ--MMDISSNGTTVVRNVPATVDIAEII------------------------------------------------------------------RNGGQISGTDSSNGMP---------------------IAFLVTTPLAIKAIPLYTSVDQPQR---------------------------LVTLSPTGTT------HGTPSSSPVGGLSQTPQEST-----------------------------VDSFEMK--------------------------------ADGNM-----------SDSAYSTADEGVAPN------------------------LSL----------------------QNNTLSLS--------------LSLSLSLSL------------SLSLSLSFLLF----------------------------------------------------------------P------------------------------------------------------------------------------------------------------------------------------------------------------------ Q8UW74.1_RecName__Full=Transcription_factor_HES_7.1_A___Xenopus_laevis_ -MK------------------------------------------------------------------------------------------------------------------------GTSEVKPMETHRK-------LLKPLVEKRRRERINNSLEKLRIFLFQTLKSE---------------------------------------------------------------------------------------------------------KLKNPKVEKAEILECTVQFLQSRKLLPLD------------------------------------------------------------------------------------------------------------------------------------------------REA-------------------VDKEYQSGFQHCLETTLHFMNSKPDMNG----VTKELLSHQMSSCKSPS-DAWSPNC---------------------------------------------------------------------------------------------------APLTKHV------------PSLSYQ--DSAPHLVS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSI---------------------SISPTKTLVD----------------------SHFTYQSF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTWR---------PWV---------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022254968.1_transcription_factor_cwo_like_isoform_X1__Limulus_polyphemus_ -MEDVKI-------------------------------------------------------VDNCWEDSNLSQNV------------KIERS-LNFAALNAHGTDDD---------------EFGLSRKRSVRDP-------MSHRIIEKRRRDRMNNCLADLSRLIPTSYLKK---------------------------------------------------------------------------------------------------------GR--GRIEKTEIIEMAIKHLKHLQAHTCK--DPGT----------------------------------------------------------------------------------------------------------------------------------------CEVAK-------------TAEQD-RRRQYRLGFQECLSEILRFMVEIEGLYAS-DGLCVKIVNH-LQQHYDKIAGGMCYQNVGVITSAE--------DSRGFP-----MDVESHTSLET--TELPSATSIA----QHHATPTSIEQNSPVQECRTEQENSKIND----------------TPLGVTIPPCTGQQAVNWNPSTSQV--QVDMETVPIS-NISGMSQLRE---MLQNPG-LPVERIRNSTSASSKNNSFVNIPTTDST----------------------AEHVFPMLTHNNSHELHRG------------------------------------------------------------------------------------------------------EEVYKFKKNIKERFT-ADLQ------------------QHASSPVRASDGEERCQDLLRY--RSTLETSNTLSSTGTANSCSSTCQSTQ-------------------GSLASQLSVKIPERNTTENGSSSN--------------------VTWDNNIDSSSSCGSNP---------------------------SPPSVVRSNGS-SSSSGYSTG-----------------------NEMPYIPKAKCNERHTPPFYQSQSVPVHCSSPQPSLPAASSIPIFALHPKGAFYVPLT---------LDSAILA--------------------------------PFFSG---------------LDDCIPVLHPV------------------------SISVN--------------------------------------------FSYGQQFKIK------------------------------------------------------------------ERAGGDMWQQ--------PSV-------------------------GYT------------------------------------------------------------------------------------------------------------------------------ Q6QB00.1_RecName__Full=Hairy_and_enhancer_of_split_related_protein_helt___Danio_rerio_ -MNARALYK---------------------------------------RP------------PPVSSSQSEASGKRRT--------RTLDALGFDNYIICNYRLVFYE---------------MMASKMKDRKKTP-------VSHKVIEKRRRDRINRCLNELGKTVPMALAKQ---------------------------------------------------------------------------------------------------------NS--GKLEKAEILEMTVQYLRALHSADFP------------------------------------------------------------------------------------------------------------------------------------------------RGREKG----------ELLTE-FANYFHYGYHECMKNLVHYLTTVERMETK-DTKYARILAF-LQSKVV---TEPVFGSLG----------------TISP---------------------DPTDLL--------CQLEYQSPS----------------------------------------------------PTESVF--QQSPPGHFSW----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSS---------------------TRSPTLAYPAM-----------------------------------------------------------------------------------------------------------------SQHSG-------------------------YLSPVQGLDHHYMNFIGHN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFSLHNAQHA-------------------------------------------------------------------------------------------------------------------------------------AL----------------------------------------------------------------------------------------------------------------------------------------------------------- A6NFD8.2_RecName__Full=Hairy_and_enhancer_of_split_related_protein_HELT___Homo_sapiens_ -M---------------------------------------------------------------------------------------------------------------------------SDKLKERKRTP-------VSHKVIEKRRRDRINRCLNELGKTVPMALAKQ---------------------------------------------------------------------------------------------------------SS--GKLEKAEILEMTVQYLRALHSADFP------------------------------------------------------------------------------------------------------------------------------------------------RGREKA----------ELLAE-FANYFHYGYHECMKNLVHYLTTVERMETK-DTKYARILAF-LQSKARLG-AEPAFPPLGS---------------LPEP---------------------DFSYQL------HPAGPEFAGHS----------------------------------------------------PGEAAVFPQGSGAGPFPW------------------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGA---------------------ARSPALPYLPS---------------------APVPLASP-----------------------------------------------------------------------------------AQQHSP-------------------------FLTPVQGLDRHYLNLIGHA-----------------------------------------------------------------------------------------------------------------------------------------------------------------HPN------------------------ALNLHTPQHP-------------------------------------------------------------------------------------------------------------------------------------PVL---------------------------------------------------------------------------------------------------------------------------------------------------------- Q7TS99.1_RecName__Full=Hairy_and_enhancer_of_split_related_protein_HELT___Mus_musculus_ -M---------------------------------------------------------------------------------------------------------------------------SDRLKERKRTP-------VSHKVIEKRRRDRINRCLNELGKTVPMALAKQ---------------------------------------------------------------------------------------------------------SS--GKLEKAEILEMTVQYLRALHSADFP------------------------------------------------------------------------------------------------------------------------------------------------RGREK-----------ELLAE-FANYFHYGYHECMKNLVHYLTTVERMETK-DTKYARILAF-LQSKARLG-AEPTFPPLS----------------LPEP---------------------DFSYQL------HAASPEFPGHS----------------------------------------------------PGEATMFPQGATPGSFPW------------------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGA---------------------ARSPALPYLSS---------------------ATVPLPSP-----------------------------------------------------------------------------------AQQHSP-------------------------FLAPMQGLDRHYLNLIGHG-----------------------------------------------------------------------------------------------------------------------------------------------------------------HPN------------------------GLNLHTPQHP-------------------------------------------------------------------------------------------------------------------------------------PVL---------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022317611.1_hairy_and_enhancer_of_split_related_protein_HELT_like__Crassostrea_virginica_ ---------------------------------------------------------------------------------------------------------------------------MEKMCKKSQVTEQ-------TSHKIIEKRRRDRINSCLSELSQTVPAAFSKQ---------------------------------------------------------------------------------------------------------TS--GKLEKAEILEMTVDYLRAIQATEIG------------------------------------------------------------------------------------------------------------------------------------------------LRFENSE-----WFSSDIWGD-FMHHYQVGYNDCIREIQRFMTDVEGLNVT-DDRYVRLVSY-LQTRFRPD-SSVTGGAAY-----------------------------------------------------RDLLQRLTMTTQ------TRRNLN-------------------VVGLGNST------------PASGFT--SYFSTGSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFSPYLYP------------------------KMISAAQT-----------------------------------------------------------------------------------QEIYTP------------------------GAFPLPSTFSANKT-ICSRTDSLGGKQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALNM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- XP_014781134.1_PREDICTED__transcription_factor_HES_4_like__Octopus_bimaculoides_ ----------------------------------------------------------------------------------------------------------------------------MDCYRQDTLVDQ-------TSHKVIEKRRRDRINNCLAELSQTVPAAFAKQ---------------------------------------------------------------------------------------------------------L----------ITCNTIHY--------------------------------------------------------------------------------------------------------------------------------------------------------------KSD-----WFTSDVWAD-FMHHYQVGYNECMQEVVRYMTDVEGIDTN-DSRCIRIMSY-LQTRFRPD-ASINTGNVY-----------------------------------------------------RDTISRVASQVT------RMQ-----------------------YGAGSNL------------TCTTGT--SIRSLH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYNPYVAQG------------------SHGT-SYLNVPSP-----------------------------------------------------------------------------------TAVVNP-------------------------VTSCPSRINNNST-NCTNATFFGR--------------------------------------NSHMNPTAFPLQNTHAHKPLLTTAL--------------------------SNSTNLPS--------------------------------------------FLFTTNNNEVIPTITDPG------------------------KLPTA-------------------------------------------TVAISER-----------------------------------------------------QP---------------QMLTKHSMRS--------PAA-------------------ITSKM---------------------------------------------------------------------------------------------------------------------------------- XP_029638240.1_transcription_factor_HES_4_isoform_X1__Octopus_sinensis_ ---------------------------------------------------------------------------------------------------------------------------MTMTTRQKERSDQ-------TSHKVIEKRRRDRINNCLAELSQTVPAAFAKQ---------------------------------------------------------------------------------------------------------SS--GKLEKAEILEMTVEYLRAVQATEIG------------------------------------------------------------------------------------------------------------------------------------------------MRFENGD-----WFTSDVWAD-FMHHYQVGYNECMQEVVRYMTDVEGIDTN-DSRCIRIMSY-LQTRFRPD-ASINTGNVY-----------------------------------------------------RDTISRVASQVT------RMQ-----------------------YGAGSNL------------TCTTGT--SIRSLH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYNPYVAQG------------------SHGT-SYLNVPSP-----------------------------------------------------------------------------------TAVVNP-------------------------VTSCPSRINNNST-NCTNATFFGR--------------------------------------NSHMNPTAFPLQNTHAHKPLLTTAL--------------------------SNSTNLPS--------------------------------------------FLFTTTNNEVIPTITDPG------------------------KLPTA-------------------------------------------TVAISER-----------------------------------------------------QP---------------QMLTKHSMRS--------PAA-------------------ITSKM---------------------------------------------------------------------------------------------------------------------------------- XP_022240818.1_hairy/enhancer_of_split_related_with_YRPW_motif_protein_like__Limulus_polyphemus_ MMKR-----------------------------------------------------------DLSDVDSDSDDIF-----------------------AVVDTKGSP---------------SQSNDEYQLLNRK-------KRRGVIEKRRRDRINNCLFELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILEMTVEHMKLLHVKGFD------------------------------------------------------------------------------------------------------------------------------------------------TFSQ------------KRHGM-FLDYHSAGFLECATEVARYLVALEGLNLK-DSLRLRLMSH-LQCYSAQK-DLAVKSA------------------ASHC---------------------SWNTSS--------SLPSFSSAPQ----NLPQTVVH---------------------------------------PTGYSV--QVSSPHNL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVVPGTSYPYY----------------------------------------------------------------------------------------------------------------NSNFAH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- XP_012940775.1_hairy/enhancer_of_split_related_with_YRPW_motif_protein_1__Aplysia_californica_ -MKR-------------------------------------------------------------SLSISDSDDGF--------------------------DERLK------------------------------------SGSQIIEKRRRDRINTSLTELRRLVPSAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKILHQKGIN------------------------------------------------------------------------------------------------------------------------------------------------TYNF------------DPHAV-AVDYRSVGFRECAAEVARYLVAVEGLDLQ-DPLRLRLLGH-LQCYSAQR-EAAAKAS------------------LQNS---------------------TWGGVG--------SMSGMSGGHS----SFTPTQYG--------------------TSS-MTT------------PMSGVI--PGQHTH-------------------------------------LNQSEHVPSMSSASHQT--------------------------------------------------------------------------------------------------------------------------------------------------------------SSV-------------------LGGSTPGIMSAGS---SFSEPT--RHAQNDSLLSGSMRLSSSSATAA------------------------------------------------------------------------------TAPVTP-------------------------MNHNSVGQSQISP------------------------------------PLFSTLPNL---------HSQFPVSLNM-----------------------------------------------------------------------------------------------NSVSSMMSSQN------------------------STS-------------------------------------------VYQNHAANQ------------------------------------------------ANSAVKP----------------------YR---------PWG---------------------GEL-AY------------------------------------------------------------------------------------------------------------------------------- XP_014767679.1_PREDICTED__hairy/enhancer_of_split_related_with_YRPW_motif_protein_1_like__Octopus_bimaculoides_ -MKR-------------------------------------------------------------SLSESEQDDVF--------------------------DDRLKA---------------GSPSQNCQVTDRK-------KRRGIIEKRRRDRINNSLSELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKVLHQKGLN------------------------------------------------------------------------------------------------------------------------------------------------GYNY-----------PDQHAL-ALDYRIVGFRECATEVARYLVTVEGMDIQ-EPLRLRLLSH-LQCYCAQR-EAAAATKTP-----------------------------------------HWSSVS--------THPTINNQYN--------------------------------GSNHMTSV-----------PNMIGT--ASTQHT--------------------------------------GQNEHHLSTISTSHSG--------------------------------------------------------------------------------------------------------------------------------------------------------------LSV-------------------ATSAVPPSYSEAR---VSQQTE--ISTPSSSALHSHMRLATTAPAVA----------------------------------------------------------------------------SASHQMAA-------------------------SLNTPTQMQQISP------------------------------------SMLPTMPQI----------SQFPVSLNS----------------------------------------------------------------------------------------------------SMMSPN------------------------NHTY------------------------------------------GSGNGVGIN-----------------------------------------------QHGPSVKP----------------------YR---------PWG---------------------TEL-AY------------------------------------------------------------------------------------------------------------------------------- XP_022335188.1_hairy/enhancer_of_split_related_with_YRPW_motif_protein_like__Crassostrea_virginica_ -MKR-------------------------------------------------------------SLSDSEAEDCY--------------------------DDSLKS---------------SSPSQSCQIGDRK-------KRRGVIEKRRRDRINNSLSELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKILHQKGLN------------------------------------------------------------------------------------------------------------------------------------------------TYNY-----------PDPQAL-AIDYRGVGFRECAAEVARYLVAVEGLDLQ-DPLRMRLLSH-LQCFSAQR-EAAAKAS------------------LQHS---------------------SWSPLP--------SHTGINSQYP--------------------------------TSA-MT-------------PMGTMI--TSQLQNQPEL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMGPHSSAQALSSLSYSEARVSQTDLSSSSLHGNMRIQSSS-----------------------------------------------------------------------------------------------------------------NMSSLSQMSNMNS--------------------------------TGQDPLISSIPQL---------SSQFQVSLNS---------------------------------------------------------------------------------------------------MPMMSQN------------------------GNNF----------------------------------------------------------------------------------------------------NSSSKP----------------------YR---------PWG---------------------AEL-AY------------------------------------------------------------------------------------------------------------------------------- Q9NQ87.2_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_like_protein__Short=hHeyL__AltName__Full=Class_B_basic_helix_loop_helix_protein_33__Short=bHLHb33__AltName__Full=Hairy_related_transcription_factor_3__Short=HRT_3__Short=hHRT3__Homo_sapiens_ -MKRPK---------------------------------------------------------EPSGSDGESDGPI------------DVGQE------GQLSQMARP---------------LSTPSSSQMQARK-------KHRGIIEKRRRDRINSSLSELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--SKLEKAEVLQMTVDHLKMLHATGGT------------------------------------------------------------------------------------------------------------------------------------------------GFF-------------DARAL-AVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSH-LNSYAAEM-EPSPTPTGP----------------LAFP---------------------AWPWSF------FHSCPGLPALSN--------------------------------QLAILGRV-----------PSPVLP--GVSSPAYPI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAL---------------------RTAPLRRATGI----ILPAR--RNVLPSRGASSTRRARPL-----------------------------------------------------------------------------------ERPATP------------------------VPVAPSSRAARSSH----------------------------------IAPLLQSSSPT----------PPGPTGSAA--------------------------------------------------------------------------------------------------YVAVPTPN------------------------SSS----------------------------------------------------------------------------------------------------PGPAGRP-----------------AGAMLYH---------SWVS------------------EITEIGAF------------------------------------------------------------------------------------------------------------------------------- Q8AXV5.2_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_like_protein__Danio_rerio_ -MKRPH---------------------------------------------------------DYSSPDSDTDELI------------DVGQE------DSYCPVTGS---------------MSPGSTSQILARK-------KRRGIIEKRRRDRINHSLSELRRLVPSAFEKQ---------------------------------------------------------------------------------------------------------GS--SKLEKAEILQMTVDHLKLLHAMGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DARAL-AVDYRTLGFRECVGEVVRYLSSLEGVESS-DPIGARLVSH-LSHCASEL-DPLLQSPAA----------------LPFP---------------------PWPWAS---------FPQLQAAS----------------------------------------------------PPASST--PFPPNARR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLAPHGTATI-----------------LGYPSPALRMGSL------------------------------------------------------------------------------------STQGT-------------------------ILNPALTSVRQLP-SVPGH----------------------------LHRLQQHSPEG----------RTVPSSSSS---------------------------------------------------------------------------------------------------SSNSSPP------------------------QISFRPF-------------------------------------VPAGSPAGGRR-----------------------------------------------ALSSSSKS----------------------AQ---------AWG---------------------TEIGAF------------------------------------------------------------------------------------------------------------------------------- Q9I9L0.2_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_2__AltName__Full=Protein_gridlock__Danio_rerio_ -MKRPC---------------------------------------------------------EDSTSDSDMDETI------------DVGSE-NNYSGQSNGSFIRC---------------GSPTTTSQVMARK-------KRRGIIEKRRRDRINNSLSELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLQATGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHSL-AMDFLSIGFRECLTEVARYLSSVEGLDSS-DPLRVRLVSH-LSSCASQR-EAAAMTTSIAHH-----------QQALHPH--------------------HWAAAL-------HPIPAAFLQQ---------------------------------SGL----------------PSSESS--SGRLSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQRGAAL-----------------FSHSDSALRAPST------------------------------------------------------------------------------------GSVAP-------------------------CVPPLSTSLLSLS-----------------------------------ATVHAAAAA--------AAAQTFPLSFPA--------------------------------------------------------------------------------------------------GFPLFSPS------------------------VTASSV--------------------ASSTVSS------------SVSTSTTSQQ-----------------------------------------------SSGSSSKP----------------------YR---------PWG---------------------TEVGAF------------------------------------------------------------------------------------------------------------------------------- Q9QUS4.1_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_2__AltName__Full=HES_related_repressor_protein_2__AltName__Full=Hairy_and_enhancer_of_split_related_protein_2__Short=HESR_2__AltName__Full=Hairy_related_transcription_factor_2__Short=HRT_2__Short=mHRT2__AltName__Full=Protein_gridlock_homolog__Mus_musculus_ -MKRPC---------------------------------------------------------EETTSESDLDETI------------DVGSE-NNYPGHATSSVMRS---------------NSPTTTSQIMARK-------KRRGIIEKRRRDRINNSLSELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLQATGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHAL-ATDFMSIGFRECLTEVARYLSSVEGLDPS-DPLRVRLVSH-LSTCASQR-EAAVMTSSMAHH-----------HHPLHPH--------------------HWAAAF-------HHLPTALLQP---------------------------------NGL----------------HTSEST--PCRLSTSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVPSAHGSALL-------------TATFAHADSALRMPSG------------------------------------------------------------------------------------GTVAP-------------------------CVPPLSTSLLSLS-----------------------------------ATVHAAAAAAT------AAAHSFPLSFAG--------------------------------------------------------------------------------------------------AFPMLPSNAA----------------------AAAAVA--------------------AATAISPP----------LSVSAASSPQQT----------------------------------------------STGTNNKP----------------------YQ---------PWG---------------------TEVGAF------------------------------------------------------------------------------------------------------------------------------- Q9UBP5.1_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_2__AltName__Full=Cardiovascular_helix_loop_helix_factor_1__Short=hCHF1__AltName__Full=Class_B_basic_helix_loop_helix_protein_32__Short=bHLHb32__AltName__Full=HES_related_repressor_protein_2__AltName__Full=Hairy_and_enhancer_of_split_related_protein_2__Short=HESR_2__AltName__Full=Hairy_related_transcription_factor_2__Short=HRT_2__Short=hHRT2__AltName__Full=Protein_gridlock_homolog__Homo_sapiens_ -MKRPC---------------------------------------------------------EETTSESDMDETI------------DVGSE-NNYSGQSTSSVIRL---------------NSPTTTSQIMARK-------KRRGIIEKRRRDRINNSLSELRRLVPTAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLQATGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHAL-AMDFMSIGFRECLTEVARYLSSVEGLDSS-DPLRVRLVSH-LSTCATQR-EAAAMTSSMAHH-----------HHPLHPH--------------------HWAAAF-------HHLPAALLQP---------------------------------NGL----------------HASEST--PCRLSTTS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVPPAHGSALL-------------TATFAHADSALRMPST------------------------------------------------------------------------------------GSVAP-------------------------CVPPLSTSLLSLS-----------------------------------ATVHAAAAAAT------AAAHSFPLSFAG--------------------------------------------------------------------------------------------------AFPMLPPN------------------------AAAAVA--------------------AATAISPP----------LSVSATSSPQQT----------------------------------------------SSGTNNKP----------------------YR---------PWG---------------------TEVGAF------------------------------------------------------------------------------------------------------------------------------- Q8AXV6.1_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_1__Danio_rerio_ -MKRNH---------------------------------------------------------DFSSSDSELDENI------------EVEKE-SADENAGANSPLGS---------------MSPSTTSQVQARK-------RRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLHAAGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHAL-AMDYRGLGFRECLAETARYLSIIEGLDNT-DPLRIRLVSH-LNSYASQR-EAHSG--------------------LGHL---------------------AWGSAF-------GTPPSHLAHHL-----LLQQQQQ--------------------QGA----------------PLARST--SSPPSSNSSS--------------------------------------------PSSSSP--------------------------------------------------------------------------------------------------------------------------------------------------------------SAP---------------------STEPRLSGTV---------------ISEAGQTGPLRVPPS------------------------------------------------------------------------------------TSLPP-------------------------GLTPPTA-SKLSP------------------------------------PLLTSLSSL----------SAFPFPLSA---------------------------------------------------------------------------------------------------FPLLSPS------------------------SLG----------------------------------------------PATPSS--------------------------------------------------SLGKP----------------------YR---------PWS---------------------MEIGAF------------------------------------------------------------------------------------------------------------------------------- Q9I8A3.1_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_1__Short=XHey_1__AltName__Full=Hairy_and_enhancer_of_split_related_protein_1__Short=Hesr_1__AltName__Full=Hairy_related_transcription_factor_1__Short=HRT_1__Short=XHRT1__Short=xHRT_1__AltName__Full=Protein_xbc8__Xenopus_laevis_ -MKRGH---------------------------------------------------------DYSSSDSELDENI------------EVEKE-SADENGN----LSS---------------MSPSTSSQILARK-------RRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLHTAGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHAL-AMDYRSLGFRECLAEVARYLSIIEGMETA-DPLRVRLVSH-LNNYASQR-EAASTAHTS----------------IGHI---------------------PWGGTF-------AHHP-HLSHPL-----LLAQTAH-----------------------------------------TNST--SSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEAHHHNRLR--------------GSPHAESSSLRVAPN------------------------------------------------------------------------------------GNIAS-------------------------VLPVVAS-SKLSP------------------------------------PLLSSMASL----------SAFPFSFGS---------------------------------------------------------------------------------------------------FHLLSPN------------------------SLS----------------------------------------------PTTPTP---------------------------------------------------SGKP----------------------YR---------PWG---------------------TEIGAF------------------------------------------------------------------------------------------------------------------------------- Q9Y5J3.1_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_1__AltName__Full=Cardiovascular_helix_loop_helix_factor_2__Short=CHF_2__AltName__Full=Class_B_basic_helix_loop_helix_protein_31__Short=bHLHb31__AltName__Full=HES_related_repressor_protein_1__AltName__Full=Hairy_and_enhancer_of_split_related_protein_1__Short=HESR_1__AltName__Full=Hairy_related_transcription_factor_1__Short=HRT_1__Short=hHRT1__Homo_sapiens_ -MKRAH--------------------------------------------------------PEYSSSDSELDETI------------EVEKE-SADENGNLSSALGS---------------MSPTTSSQILARK-------RRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLHTAGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHAL-AMDYRSLGFRECLAEVARYLSIIEGLDAS-DPLRVRLVSH-LNNYASQR-EAASGAHAG----------------LGHI---------------------PWGTVF-------GHHP-HIAHPL-----LLPQNGH---------------------------------------GNAGTT--ASP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEPHHQGRL---------------GSAHPEAPALRAPPS------------------------------------------------------------------------------------GSLGP-------------------------VLPVVTSASKLSP------------------------------------PLLSSVASL----------SAFPFSFGS---------------------------------------------------------------------------------------------------FHLLSPN------------------------ALS----------------------------------------------PSAPTQ------------------------------------------------AANLGKP----------------------YR---------PWG---------------------TEIGAF------------------------------------------------------------------------------------------------------------------------------- Q9WV93.1_RecName__Full=Hairy/enhancer_of_split_related_with_YRPW_motif_protein_1__AltName__Full=Hairy_and_enhancer_of_split_related_protein_1__Short=HESR_1__AltName__Full=Hairy_related_transcription_factor_1__Short=HRT_1__Short=mHRT1__Mus_musculus_ -MKRAH--------------------------------------------------------PDYSSSDSELDETI------------EVEKE-SADENGNLSSALCS---------------MSPTTSSQVLARK-------RRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---------------------------------------------------------------------------------------------------------GS--AKLEKAEILQMTVDHLKMLHTAGGK------------------------------------------------------------------------------------------------------------------------------------------------GYF-------------DAHAL-AMDYRSLGFRECLAEVARYLSIIEGLDAS-DPLLVRLVSH-LNNYASQR-EAASGAHGG----------------LGHI---------------------PWGSAF-------GHHP-HIAHPL-----LLPQNGH---------------------------------------GNAGTA--ASP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEPHHQGRL---------------ASAHPEAPALRAPPS------------------------------------------------------------------------------------GGLGP-------------------------VLPVVTSASKLSP------------------------------------PLLSSVASL----------SAFPFSFSS---------------------------------------------------------------------------------------------------FHLLSPS---------------------------------------------------------------------------TPTQ------------------------------------------------AANLGKP----------------------YR---------PWG---------------------TEIGAF------------------------------------------------------------------------------------------------------------------------------- XP_022345726.1_transcription_factor_HES_1_like__Crassostrea_virginica_ -MAP-----------------------------------------------------------------------------------------------TETKDEVKK---------------EAVHSSTGSPKRR-------VNKPMIERRRRERINECLNQLQTLISQLDKDK-------------------------------------------------------------------------------------------------------QKIGKSNKLEKADILEMTVDFVKRSHPPPKE------------------------------------------------------------------------------------------------------------------------------------------------ESE-------------QREHLSESVQYIAGYEKCRNEIQNFLQSSENVPD---DVRSALIGH-LQMNSTSK-SSESIAVKPPAA-------------DQTPKS-------------------SATTSL------PNILPRVSSSCI------ASIASS--------------------TTCQTTTQL----------PGNKNV--FICNPSAPTY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLVP----------------------------TAT-------------------LCQPVPINSQM------------------TRTNDSPLNLVKT-------------------------------------------------------------------------------SRTGSDIVTS-------------------------SVPPTSTMQLGSV-------------------------------------------------VNGNQFFVIPQGQISNMPNFMASSV-------------------------GGQSNIMTT-----------------------------------------------NSIQGMQGNFLCMPN-----------------------LQVSLA-------------------------------------------------------------------------------------------------------SP----------------QLDNDVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- G5EF76.1_RecName__Full=Helix_loop_helix_protein_lin_22___Caenorhabditis_elegans_ -M--------------------------------------------------------------------------------------------------TSFLCSDT---------------EIESDGGISRCKKI------KNKPLMEKKRRARINKSLSQLKQILIQDEHKN---------------------------------------------------------------------------------------------------------SIQHSKWEKADILEMAVEYLQQLRSAQPCSLSP-------------------------------------------------------------------------------------------------------------------------------------------STSS-------------ISTPP-TPKEEIRNIKVPLNPIASFLNPMMQ-----QYVAYQQLAQ-LSMYTQLF-NNPAGV-----------------------------------------------------------------------------------------------------------------------PLRADA--GVT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQSPELA-------------------------EKLKIEDR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------- XP_005089291.1_transcription_factor_cwo_isoform_X1__Aplysia_californica_ -MTEKSKHQLG-----------------------------------EDLPDISSWRQLCW--SKVAMEGEESNQSLMDESGIKRAKRAKMEAA-ETDRGESFQNSLDSVRHGLLNFATAADELELSLKRQKMPRDP-------MSHRIIEKRRRDRMNNCLADLSRLIPSSYHKQ---------------------------------------------------------------------------------------------------------GQ--GRIEKTEIIEMAIKHINMLQQRVDE------------------------------------------------------------------------------------------------------------------------------------------------SEKRAQDDKPPPQPPPPSDQRCCATKFYMGFKEAQDEVMRFLVEVESVSAM-DPFCKKIMKH-LENASKKF-ITEHVPHHSRLRPGELDKQELDNDNSGQPAF------------------LQSSSAF------YESSPVVGRVGQ------EEQGLAVDSK---------------HRDKHLRSLLADQQHSVV--SSQGSG--SVSETGSNGLVPLFSYSSQ-------------------MTSIGGSADPSGMGSSGYVSDL-------------------SNTEKTSPNSSTSSR------------------------------------------------------------------------------------------------------------DNVYKFKHNITKRFSQEGHHMQQHHHHHHHH-------LHNGQPSDTSSST------------SSRDLEDDQRQLKWKGTKHKARHSGL----------------------------------------------------------------DSADTLYRDDVEASSN-------------------------GNNSVNSDEFNSA-SVSSG----------------------------DCKRRRNSGKT-------SAQSPGPPTLNGESRSNTSSFILPGFILHPSGTHYMPIS---------VQNTNIS---------------------------------------------GLLDNSLDNEGPPVFHPI------------------------SIPVH-------------------------------------------------------------------------------------------------------------------------------FRR--------PVI---------------------------------------------------------------------------------------------------------------------------------------------------------- KOF86952.1_hypothetical_protein_OCBIM_22017755mg__Octopus_bimaculoides_ -MARQGSN---------------------------------------------------G--VKLELNDSPLNFA------------------------TSVEDYEMH---------------GPPTKKPKTPRDP-------MSHRIIEKRRRDRMNNCLADLSRLIPANYMKQ---------------------------------------------------------------------------------------------------------GQ--GRIEKTEIIEMAIRHIKHLQNIHRS------------------------------------------------------------------------------------------------------------------------------------------------LV--------------NQGQC-CAEKFYLGFKECEAETIRYFVECEGLDNK-DQFFMRVISH-LEAVSKKH-LATGTQNCTDFP-------------KEEPSSGDKANISCSSLNAECDNKMKSNDRT------LQTVPEILAPSH------DSINSA--------------------ASKQLRSLLS-QGNAGFEQPDSGNA--SCADSLGM------FSSSE-------------------SSISGNNADEVNMNMNNGEGDMHYHG------NVGSENGSSSGSSKENKFTNYKFKHDITKRFSEEEKYSVDISASLTQENIIEYQENHNYDKLGYEKHSKDKHGYDKHGHDKHDKHGHDKHDKHGHDKHSHDKHDKHGHDKHGHDKHSHEKHGYDKHEKHGYDKHGFEKHEKLSSKLK-RKI-------------------VRSMSPSSCSDS---TAYPTSE--HSSNGASNNVSTMLCHSPEDETVNNGVHLPAFVLHPQGTHYLPLTIQQSCFQNSLQQVERTQQPIVFHPISILVNFATPGLVIQNAESFVNNAALDVTFSSSSSSST-------------------SASAAAAANAAADATADATTSAGAPLAEN--------------------GNSNNARSITLVNSNN---NNNNNNCPSPVINKPSLSHNCTTITSP-YNLSPANSCHSVGSNNSSTSSSGSSSSSVT--------------------------------AVNNN---------NNNNNNSTVNTTATIPL------------------------NAIQANNHMSPVKHGNNTDHMNSGPVVVNSATSLPQ-----TSSPPAATPTVTTATALLQ--------TPTGALITQSI---------------LHQQQQQQQQQQQQQP----------PLQPQHLPIHQTWNGYSRNGLLNPVQE------------------VQVNEGASH----------------------------------------------------------------------------------------------------------------HVAA---------- Q5TGS1.1_RecName__Full=Transcription_factor_HES_3___Homo_sapiens_ ----------------------------------------------------------------------------------------------------------------------------------------------------MEKKRRARINVSLEQLKSLLEKHYSHQ----------------------------------------------------------------------------------------------------------IRKRKLEKADILELSVKYMRSLQNSLQG------------------------------------------------------------------------------------------------------------------------------------------------LWP-----------VP------RGAEQPSGFRSCLPGVSQLLRRGDEVGS---GLRCPLVPE-SAAGSTMD-SAGLGQ--------------------------------------------EAPALF------RPCTPAVWA------------------------------------------------------PAPAAG--GPRSPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLLPES------------------------------------------------------------------------------LPGSSASVPPP---------------------------QPASSRCAESP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLGLRVWR---------PWGSP--GD----------DLN--------------------------------------------------------------------------------------------------------------------------------------- Q61657.2_RecName__Full=Transcription_factor_HES_3___Mus_musculus_ ----------------------------------------------------------------------------------------------------------------------------------------------------MEKKRRARINVSLEQLRSLLERHYSHQ----------------------------------------------------------------------------------------------------------IRKRKLEKADILELSVKYMRSLQNSLQG------------------------------------------------------------------------------------------------------------------------------------------------LWP-----------VP------SGVDYPSGFQGGLRGVSQRLRPGEG-DS---GLRCPLLLQ-RREGSTTD-SANP----------------------------------------------QATSVL------NPCLPAIWA------------------------------------------------------PSRAAG--GSHSPQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLPLPGG------------------------------------------------------------------------------LLESSTDVVAP---------------------------HPASNCQAEST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGFRVWR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- XP_022345680.1_enhancer_of_split_m3_protein_like__Crassostrea_virginica_ -MSSKA---------------------------------------------------------------------------------------------AKRSGFAEK---------------IKKVSENQTPNRK-------VNKPQTERKRRERINKCLGQLKSLVFKATGKD---------------------------------------------------------------------------------------------------------EKKYPRLEKADILEMAVNHLYALNGKDCN----------------------------------------------------------------------------------------------------------------------------------------------------------------IGGKE-TEDRFREGYSRCIGEVLQCLRFERGIDV---VTKTNLINH-LTVSLTQL-SANPDAGYINQG----------------------------------------------------------------------------------------------FELSVDS------------DSSSVS--GSGKFAHPTS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGV---------------------QEVPAFVQPKF---------------------AEMYFQDQ-------------------------------------------------------------------------NLYMDFYNAPLDVRNP-------------------------EVNPLIAERMAGV---------------------------------------------------ECQLPCSPFRSEFGVP--------------------------------LHTSTPVA---------------------------------------------------KKRLGVVPDFPALE----------------------EINLSDC---------------------------------------VATSSSSDS-------------------------------------------------GNSAGP----------------------WR---------PW----------------------------------------------------------------------------------------------------------------------------------------------------------- NP_524775.1_clockwork_orange__isoform_A_Drosophila_melanogaster -MEPYWNETNG----------------------------------HAAHP------------VKYESEAAVSSFPYC----------TESSLNFSTSATAYSEDDAEY---------------ATGRRNKTSRQDP-------LSHRIIEKRRRDRMNSCLADLSRLIPPQYQRK---------------------------------------------------------------------------------------------------------GR--GRIEKTEIIEMAIRHLKHLQSECQQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------KESDYRSGYMDCMKEAAKFLYDVHMQDFC-HRLLGRLQEH-IDEMFKTD-CYKSTRSCHMPDNVS--------ASSGSPHQ-----AYHPPLCHL-RDMLATSASDVEHSQDHNDVKDLSFRNHLNQLQRSQQAAAAAAVAAAAVAVANGSSPASNAGVDSKVPLTNGGGTGGAPPAADNV--PSNSTGSGSA----------------------------AACAGGNSNSSGSNSSNAASSTI------------CPPAGGSCPAKVTPLAAHQQPHQ-----------APVITST--------------------------------------------------------------------------APH------------HHHHHTDSSHHDFE-SSREPILHTDTSNMHSPPPRDLLLQQHPHLAHSHH----------------TQDSLMSVRMRNY-SESSHEIEHNNNY-------KYKNHIKERFVHELHDEETSSEHCPVAAHLQSD------------------HSHLQALSEHSKDGTEPEIAPIM-------AKKRKLAEAAANGEIPLEVHTESSNAGASSANRLDKPSPSFNFSDIKDIKAELHNGNSNSSPLLAKLSAV----AAAGGQLSTPSSTTAPLPPRHTFTV-PIFALHGQGNYYVPLN---------VDYNALV--------------------------------PFLNG---------MDLLEKSYTSMPVVHPI------------------------NINVNF-------------------MPSSPSASL-------LAAAAAAAVAVGKQQQQQA----VVAAGAGLPLSTNS----------------AAAQAAAVAAAAVAKA----------------KLEQAMNQ---------SW-----------------------------------------------------------------------------------------------------------------------------------------------------------