### Title of dataset #Evaluating the effects of pod-based electronic cigarettes on human endothelial cell function ### Description of the data and file structure ##The files here consist of data that were used for analysis and plotting ##"penos_ppts.xlsx" consists of data from venous endothelial cells collected from study participants to measure endothelial nitric oxide synthase (eNOS) #The column labeled "enos_change" includes the change in eNOS activation via phosphorylation between unstimulated and acetylcholine-stimulated endothelial cells collected from participants following product used #The column labeled "status" indicates the participant's status of tobacco product use #The column labeled "pod_user_type" indicates whether the specific result was from a sole user or dual user among the pod users ##"cell_culture.xlsx" consists of data from the experiments conducted using human aortic endothelial cells cultures ##The "TUNEL" sheet includes the percentage of TUNEL positive (apoptotic) cells among those counted #The column labeled "Control" includes TUNEL results of cells in media alone (no e-liquid) for all cell experiments #The other columns include TUNEL results of cells exposed to six different dilutions per specified e-liquid: 10^-5%, 10^-4%, 10^-3%, 10^-2%, 0.1% and 1% ##The "DAF2_eliquid" sheet includes normalized values (to mean control) of percent change in DAF2DA fluorescence between unstimulated cells and A23187-stimulated cells exposed to treatment #The column labeled "Control" includes normalized DAF2 changes for all cell experiments unexposed to any e-liquid #The other columns include normalized DAF2 changes for cells exposed to either of two dilutions for each tested indicated e-liquid: 10^-5 and 10^-4 ##The "DAF2_HF" sheet includes normalized values (to mean control) of percent change in DAF2DA fluorescence between unstimulated cells and A23187-stimulated cells exposed to 0.001% of the specified e-liquid heated fractions #The column labeled "Control" includes normalized DAF2 changes for all cell experiments unexposed to any e-liquid #The other columns include normalized DAF2 changes for cells exposed to 0.001% diluted heated fraction in ethanol for mango, menthol, mint, Virginia Tobacco, and PG:VG e-liquids, as well as condensates for Standard Cig (reference 3R4F) and Low Yield Cig (reference 1R5F) ##The "IL6_RQ" sheet includes normalized values (to mean control) of the IL-6 2^-(ΔΔCt) values calculated using GAPDH as the reference gene #The column labeled "Control" includes normalized IL-6 2^-(ΔΔCt) for all cell experiments unexposed to any e-liquid #The other columns include normalized IL-6 2^-(ΔΔCt) for cells exposed to either of two dilutions for each tested indicated e-liquid: 10^-5 and 10^-4 ##The "Mitosox" sheet includes the normalized values (to mean control) of the MitoSOX fluorescence intensity of cells exposed to e-liquids #The column labeled "Control" includes normalized fluorescence intensity for cell experiments unexposed to any e-liquid #The other columns include normalized fluorescence intensity for cells exposed to 10^-5% dilution for each of the specified e-liquid. Menadione was used a positive control treatment.