a) 10 20 30 40 50 60 70 80 90 100 . . . . . . . . . . CLU NNGACCAACATTCGAAAAACCCACCCACTAGCCAAAATTGTTAATAACTCATTCATTGACCTCCCAGCGCCGTCTAACATCTCTGCTTGATGGAACTTCG CLA AT..................T..........T.......................................A..C....................T.... CSI AT........NN...........................................................A.......................T.... CAU NNNNNNNNNNNA....................T......................................A.......................T.... CMES AT.........A....................T...........C.......................A..A...........C........A..T.... CMET AT.........A........T...T.......T...........C.G...............T........A..C...........C.....A..T.... CAL AT................G.............T...................................A..A...........C................ LPI NNNNNNNNNNNNN..............T...........A.C..C..............T......A....A..C..T..T...........A..T.... CBR NN.....................T...T...TT......A............................A..A...........CA.......A..T.... SVE AT..................T.....GT....T......A.C..C........T............A.A..A..C.....T..............T.... CAD NNNNNNNNNNNA....................T......................................A.......................T.... CTH AT..............................T...........C........T..............A..A.....T..T..C........A....... AMI NNNNNNNNNNNN........T...........T...........C........T..............A.....C.....T..C........A..T.... DSE AT..................T...........T...........C........T.....T..T...A.A..A..C..T..T..C................ DGY NNNNNNNNNNNNN...................T...........C........T.....T..T.....A..A..C..T..T..C................ DVE NNNNNNNNNNNNN...................T...........C........T.....T..T.....A..A..C..T..T..C................ DCU NNNNNNNNNNNNN...................T...........C........T.....T..T.....A..A..C..T..T..C................ DGR NNNNNNNNNNNNN...................T...........C........T.....T..T.....A..A..C..T..T..C................ OME NNNNNNNNNNNNN...............................CG.......T.....T..T..C..A..A.....T.....C........A.....T. FZE NNNNNNNNNNNNN...................T...........CG.......T............A.A..A..C.....T..............T.... VVU AT........CC.....G..T...........T........C..C...........C.....T..C..A..A..A..T........C...........G. VMA NNNNNNNNNNNN.....G..T...........T.....C.....CG.T.................C..A..A..C.....T.....C.....A....... NPR AT.........C......T...................C.....C........T.....T.....C..A..A..A...........C.....A....... UCI AT........................G.....T.....C..C..C.G.........C.....A..T..A..A........T.....A............. PVI AT.........C...........T......ATA......A.C..C...........C.....A..CA.A..A..A..T.....G..A.....A.....T. 110 120 130 140 150 160 170 180 190 200 . . . . . . . . . . CLU GATCCTTACTAGGAGTATGCTTGATTCTACAGATTCTAACAGGTTTATTCTTAGCTATGCACTATACATCGGACACAGCCACAGCTTTTTCATCAGTCAC CLA ....................C............................T........A......................................... CSI .................................................T........A.............................C........... CAU .G..G..GT...........C......................C..............A.....C......................A............ CMES ....T...T.G.........C...................T........T........A...........A..T.....T..G..C.............. CMET ........T...........C......................C..G..T.....C..A..............T...........C.............. CAL ....................C............................TC.......A...........A..............C.............. LPI .....C.............TC.A.................T..CC....TC....A..A.....C.....A..T.....T.....C.............. CBR .......G.....G........A..........................T........A.....C........T..T........C...........T.. SVE .G...C..........G...C......................CC....T........A.....C.....A......A.......C...........TG. CAD .G..G..GT.........................GAC............TC.......A.....C.....A..............C.............. CTH .......G...........................GC................................................C.............. AMI .G..T..GT..........................A......................A..............T..T........C.............. DSE .....C.............................A......................A..............T..............C........... DGY .....C.G...........................A.......C.............................T........G.....C........... DVE .....C.G...........................A.......CC............................T........G.....C........... DCU .....C.G...........................A.......CC............................T........G.....C........... DGR .....C.G...........................A.......CC.............A..............T........G.....C........... OME .....C.GT...........C..............GC.............C....C..A.....C.....A.....G........C.............. FZE .G...C.G.....C.......CT............G........C....TC.G.....A.....C.....A......A................G...G. VVU .TC..C.G.....T......C.T............G........C....T.....C..A...........A........T..T..C.............. VMA .....C.C.....T..C...C.C............A.......CC....TC....C..A.....C.....C..T.....T..T..............T.. NPR ....AC.G...........TC.T............A........C....TC....C..A...........A..T..CTTT..T..C...........T.. UCI .G...C.GT.....A.C...C.T............A.......C........G..C..A.................C........C........C..T.. PVI ....TC.T..C...A.C...C.A..C..G.....CT.......C......C....C..A.....C..C..A......A.......C..C........A.. 210 220 230 240 250 260 270 280 290 300 . . . . . . . . . . CLU CCACATCTGCCGAGACGTTAACTACGGCTGAATTATCCGCTATATGCACGCAAATGGCGCTTCCATATTCTTTATCTGCCTATTCATACATGTAGGACGA CLA .........T................................C..A..T..........................T..T..G...........G...... CSI T........T.....T.............................A..T.................G...........T..............G...... CAU ......A......................................A..T.....C...................................C......... CMES T...G....T.....T...........A.....C...........A...................................................... CMET T..............T.............................A..T.....C.....C.......................T............... CAL .........T...................................A..T..............T....................T.....C......... LPI ...T.....T.....T.....T..T.................C..A..T.....C..T..C.............................C......... CBR T.......................T.................C..A..T..G..C.....C..T...............T....T........G...... SVE .........T.....T........T....................A..T...........C..A..............T.....T............... CAD .........T.....T.............................A..T.....C..A.....T..........................C......... CTH T..............T.....T....................C..A..T........T..C.................T..G.................. AMI T....................T..............T.....C..A..T...........C.................TT................G... DSE T..............T.....T....................C..A..T...........C.................T.....T............... DGY T..............T..C..T....................C..A..T.....C.....C.................T..................... DVE T..............T.....T.................T..C..A..T.....C.....C....................................... DCU T..............T.....T.................T..C..A..T.....C.....C....................................... DGR T..............T.....T....................C..A..T.....C.....C..................T.................... OME ..................A..............C..T.....C..A..T.....C..A.............................G.....C...... FZE A.......................T.....G..C........C..A..T.....C..A..........................T..G..C......... VVU T.......................T..............T..C..A..T........A..C...........C........C..T..G..C......... VMA A.....T.............................T.....C..A..T........A..A..T........C..T..T..G.....G..C..G...... NPR A.................C..T...........C...........A.....G..C..A..C..............T.....C.....G..C..G...... UCI ...T.....T..............T........C...........A.....C..C..A..C..A........C............C.G..C......... PVI ..................A..............C.....T...C.T...........A...........T..C..........A...G............ 310 320 330 340 350 360 370 380 390 400 . . . . . . . . . . CLU GGCCTATATTACGGATCCTATGTATTCATAGAAACATGAAACATTGGAATTGTACTATTATTCGCAACCATAGCCACAGCATTCATGGGCTATGTANNNN CLA ...T....C................................................C............................A.........NNNN CSI ........C................................................C............................A..T......ACTC CAU ........C................................................C....T.......................A.....C..CACCC CMES ........C..T..........................................T..C..........T.................A..T..C..CACTC CMET ........C.....C..........................T.........A.C..CC.G..T.....T.................A..T..C..CACTC CAL ...........T..G......................................T..GC....T.....T.................A.....C...NNNN LPI ........C..T.....T................................C...........TAT...T.................A..T..C...ACCC CBR ........C..T.....T...A......................C...G.C.....G...C.......T.....T...........A.........NNNC SVE ...T....C.....G......A...................T........C...T.....C.TT..........T...........A..T......ACTC CAD ........C.......................................G........C............................A.........ACCC CTH ..T..G..C..T.....A.......................T......G.C...........T.....T...........................ACCC AMI ...........T..G..A...A............................C......C....T.....T.................A.........ACCC DSE ........C..T.....A.......................T........C......C.G..........................A.NNNNNNNNNNNN DGY ........C..T.....A.......................T........C...T..C............................A.........ACTC DVE ........C..T.....A.......................T........C...T..C............................A.........ACTC DCU ........C..T.....A.......................T........C...T..C............................A.........ACTC DGR ........C..T.....A.......................T........C......C............................A.........ACTC OME ..T..G..C..T.....T..C....................T..C......A.TT.GC....A.....T.......................C..CNNNC FZE ...T....C..T..C.....C.......................C......A.CT..C.G..A...........T...........A..T......NNNC VVU ...T....C..T..C..........................T.........A.C..CC.G..T.......................A.....C..CACTC VMA ...T.......T........C.......................C........CT..C.........................T..A..T..C...ACCC NPR ........C..T.........AC...............G.....C...G.AA.C...C.....A.G........T..G........A..T..C..CNNNN UCI ..A.....C..T.........AC..................TG........A.C...C....T..G..T.................A.....C..CNNNN PVI ..A..G........C.....CAC.....C...G...........C..C...A.C..C......A.CGT......T.................C..CACCC 410 420 430 440 450 460 470 480 490 500 . . . . . . . . . . CLU NNCCACATATTAAACCTGAGTGATATTTCCTATTCGCCTATGCTATCCTACGATCCATTCCTAATAAATTAGGAGGCGTACTCGCCCTAGTATTCTCCAT CLA NNN....C........C..A....................C....................C......C................T.............. CSI CT..............C.................T.....C.................C........GC............................T.. CAU CT........C........A.....C.................C...........T..C.................T....................... CMES CT.....C..C........A.......................C...........T....................T....................... CMET CT........C........A..............T.....C..............T..C..........................T...........T.. CAL NN........C........A.....C........T.......................C.........C.......T........T.............. LPI CT.................A.....C...T..........C..............T..C.........C.......T...............C....T.. CBR CT..............C..A..G.................C...........................C.......T....................T.. SVE CT.....C..C........A.....C..............C...........G.....C.....C...C............................T.. CAD CT..C.....C........A.....C..............C..C...T....................C.......T.........T............. CTH CT..............C..A..............T.....C...........G..T..C.....C...C.......T.....A................. AMI CT........C.....C..A..G...........T.....C..............T..C.....C...C.G.........T.A..............A.. DSE NNNNNNN.........C..A..G..C..T.....T...........TT..........C.....C...C.......T.....A...........T..... DGY CT..............C..A.....C........T.....C.....T.....G..T..C.....C...C.......T.....A...........T..... DVE CT..............C..A.....C........T.....C.....T.....G..T..C.....C...C.......T.....A...........T..... DCU CT..............C..A.....C........T.....C.....T.....G..T..C.....C...C.......T.....A...........T..... DGR CT.................A..............T.....C.....T.....G..T..C.....C...C.......T.....A...........T..T.. OME CT.....C..C.....C..A..G......T..........C....................A......C.C.....A..C..T........G..T..... FZE CT.....C..C.....C..A..G......T....T.....C.....T...........C.....C...C.......A..T........G........T.. VVU CC........C.....C..A..G..C........T...........T..C..G.....C.........C.......A..C..A..T.....G.....A.. VMA CT........C.....C........C..............C.....T..C..G..T..C.....C...C....G..A..C.................... NPR NNNNNNNNNNN.....C..A.....C..............C..C........G..A........C...C.......A..C.................A.. UCI NNNNNNNNNNN.....C..A.....C..............C..C...T.......A..C..C..C...C.......A..G...........G.....A.. PVI CA........C.....C..A..G..C........T.....C..A...T..........C..C..C...C.......A.....A.........C....... 510 520 530 540 550 560 570 580 590 600 . . . . . . . . . . CLU CCTAATCTTGGCATTCATTCCACTCCTCCACACATCTAAGCAACGCAGCATAATATTCCGGCCCCTAAGCCAATGCCTATTCTGACTTCTAGTCGCCGAT CLA .......C..............T................A....................A...........................T........... CSI .......C.A............T.............C..A.................T..A..T..C..T..........................T... CAU ......T..A............T.........................T...........A.....C.....................T........... CMES .......C.........C...TT.......T........A........T........T..A.....C.....................T........... CMET T......C.A.......C...TT................A.................T..A..T..C.....................T........... CAL T......C.......T.....CT.............C........A...........T.....T..C................................C LPI T......C.A...........CT.............C....................T..A...............T.......G...T...C......C CBR T......C.AAT....G....C..T..............A....A............T..A..G..C..............T.........ACT...... SVE .......C..AT.C.......C........T.....C..A..G.....T........T........C.........T....T.....CT...C...T..C CAD .......C.A.......CC..CT................A.................T..A.....T.........T........T..T..AC...T..C CTH T..G...C.A...C.......C..TT..........C........T..............A.....T.....................T..AC...T... AMI .......C.A...C.T.....T..T...........C..A.....T...........T........C..............T.....AT...C...A... DSE .......C.A...C.......T..T..T........C........T..............A.....T........T.....T.....CT...C.A....C DGY .......C.A...C.......T..T..T........C........T....................T........T.....T.....CT...C......C DVE T......C.A...C......NT..T..T........C........T....................T........T...........CT...C......C DCU .......C.A...C.......T..T..T........C........T....................T........T...........CT...C......C DGR .......C.A...C.......T..T...........C........T....................T........TT....T.....AT...C...T... OME .......C.A...C.T.....TA.A...........C.........G.A.....G.....A..A.....T......T....T.....C...ACT.....C FZE ......TC.A...C....C..CT.A........C..A..A......G.A........T..A.....T........................ACT.....C VVU .........A...C.T..C..C.A...A.....C..A..A.....TG.A...........A.....T..T.....................AC...A..C VMA .........A...C....C..T.A......T..C..A..A......G.A...........A.....C..T.................C...AC...A..C NPR .......C.A.T...A..C..C..............C..A.....TG.A...........A..A..T..T......A.G........A..TACA..T... UCI .T.....C..........C.....A..T........A..A......G.A.....G.....A..T..C..T.....TT.G.........T..ACT...... PVI T..TG..C.C..TA....A..C..A...........A..A.....AG.A...........A...A.C..................T.C.....A..A..C 610 620 630 640 650 660 670 680 690 700 . . . . . . . . . . CLU CTTCTCACTTTAACATGAATTGGAGGACAACCAGTTGAACACCCTTTCATCATTATCGGACAAGTCGCTTCAGTTTTATATTTCACCATCTTATTGATCC CLA ........C............................................C..............C......C......................T. CSI ........C...........C..............A........C..T...........C........C......C....C..T..T...........T. CAU ..............T..G...........G.....A........C..................A....C...A..C......................T. CMES .....T.......................G.....A...........................A....C.....CC.......T......C....A.... CMET .....T....................T..G.....A.................C.........A.T..C.....CC..............C....A...T CAL ....................C........G.....A........C..T........T......A....C......C.......T.T....C.......T. LPI ..C..T.............................A........C..T.....C..T.....GA....C..CA..C.......T.T.............. CBR ..C..T...C..........C.....G........A........C.....T..C..T..G...A.......TA.CC....C..T..............T. SVE .....T..CC.........................A..G........T..T..C..T..G...A....C..TA.CC.............TC........T CAD ........C....................G.....A........C..T..T.....T......A....C..TA..C....C.....T......C.A...T CTH .....T.......................G.....A........C..T........T......A....C..CA.CC....C..T..T...........T. AMI .....G....................G..G.....A..............T............A....C..CA.CC....C..T..T...........TT DSE ...................................A.....T.....T...............A....C..CA.CC....C.....T........A..T. DGY .....T..C..........................A...........T...............A....C..CA.CC....C.....T...........T. DVE .....T..C.....NN...................A.....T.....T...............A....C..CA.CC....C.....T...........T. DCU .....T..C..........................A.....T.....T...............A....C..CA.CC....C.....T...........T. DGR .....T..C.................G..G.....A...........T...............A....C..CA.CC....C..T..T...........T. OME ...A....AC.......G..C..............G........C..T..T..C..T..C..GA.......CA.CC....C..T.....TC.......T. FZE ..C.....A..........................A........C........C..T..C...A....C..CA.CC....C..TG.T.........G... VVU ..C.....C.....T...........G..G..G..A........C..T.....C..T..C...A.T..C..CA.CC.......TG.T...........T. VMA ..C.....C.....C..............G.....A........C..T.....C.....C...A....C..TA.CC....C..TG.T...........T. NPR ..C.....G.............C...C.....G..C.................C.....C...A....C..CA..C....C..T..T............. UCI ..C..T..AC..........C.....T..G.....G........C.AT........T..C...A....C...A.CC.......T.........C..G... PVI ..A.....AC..........C..............C..........AT....CCG.T..T...C.A..C...A.CC....C..T..A...C.CC.AG.A. 710 720 730 740 750 760 770 780 790 800 . . . . . . . . . . CLU TAATACCAACAGTTAGCGTTATCGAAAACTTCTGATTCTTCGGGCATCCTGAAGTTTACATTCTTATCCTGCCCGGATTCGGAATAATTTCTCACATTGT CLA .........T.A................T..............A........................................................ CSI ..........TA........................................................................................ CAU ....G.....CA................T..............A..........................AG....G....................... CMES ........GT.A.......C........T..............A........G.....T...................................T..... CMET ........G..A.......C........T..............A........G...........C.............................T..... CAL .........T.A.C..............T........T.....A..C....................T..A.................C........C.. LPI .C.........A.....A.C........T.................C..C..............A........T..G...........C........... CBR ...........A.C...A..........T..T.....T.....A........G.....T..C..A.....A..T...........G..C.....T..... SVE ..........GA.....A..........T.................C..C...........C..A...........G...........C........... CAD ...........A.C..TA.C........T..T...........A........G...........A........T.....T..............T..... CTH ..........GA.C...A..........T..............A..............T..C..A..TT.A..T.....T.....G..C.....T..... AMI ..........GA.C...A..........T...........N..A.....N........T..C..A..TN.N..T..N..T.....N..C.....T..... DSE .........TG......A......................T..A..............T..C..A..T.....T.....T.....G..C.....T..... DGY .........TG......A......................T..A..............T..C..A..T.....T.....T.....G..C.....T..... DVE .........TG......A......................T..A.....C........T..C..A..T.....T..G..T.....G..C.....T..... DCU .........TG......A......................T..A..............T..C..A..T.....T.....T.....G..C.....T..... DGR ..........GA.....A......................T..A..............T..C..A..T.....T.....T........C.....T..... OME ....G....TCA.C...A.A...........T.....T.....A..............T..C..A..T........G..T.....G..C.....T.CC.. FZE ....G.....TA.C...A.............T.....T.....A..C..C.....C......T.A.....A...........T..G..C..C..T..... VVU ....G.....CA.....A.............T...........A...........C......T.A...T....T..G..T..T.....C..C.....C.. VMA ....G.....CA.....A....T.....T..T...........A..C..C..G..C..T...T.A...T....T..G..T..T.....C..C.....C.. NPR ..........CA.CG.TA.C........T...........T..A........G.....T..CT.A...T....T..G..T...........C..T..C.. UCI ....G.....TA.C...A...................T..............G..C..T..C..A........T.......................C.. PVI .C.....C.TT.CC...A.C........T..............A........G..G..T.....A.....A..A..............C..A.....C.. 810 820 830 840 850 860 870 880 890 900 . . . . . . . . . . CLU CACTTACTACTCAGGGAAAAAAGAGCCTTTCGGTTATATAGGAATAGTATGAGCAATAATATCTATTGGGTTTTTAGGCTTTATCGTATGAGCTCACCAT CLA T................................C.....G...........G................................................ CSI .................................C..............G..G................................................ CAU .................................C.................G................................................ CMES T..C.....T.......................C...........................................................C...... CMET T..C.............................C..............................................................T... CAL ...C..T..........................C...........G.....G..............C.....C........C.................. LPI ...C.............................C.................G.................A..C.......................T... CBR ......T..T..............A..C..T........G...........G.................A...C..........T..............C SVE T.....T........T..G..G...........C........G.....G....................A...C....T..................... CAD T........T.................C..T..C.................G.................A..C........................... CTH T.......................A.....T.....C...................................C........C..T............... AMI N..N..T..N..............N.....N..N..N..N................................NN....N..N..N.....N.....N..N DSE ......T..T....................T..C..C...............................................T.....G.....T..C DGY ......T.......................T..C..C....................................C....T...........G.....T... DVE ......T..T.......................C..C.......................G.................T.....T.....G.....T... DCU ......T..T....................T..C..C.........................................T..C..T.....G.....T... DGR ...C..T.......................T..C..C.........................................T.....T.....G.....T... OME G..C....................A.....T..............G..C...........G........A.......................C.....C FZE ...........................C..T..C...........G..T.....G.....G..C..C..A..C..G.................A.....C VVU ...C.....T.....A..G........C..T.....C..G.....G..............G.....C..A..C..........................C VMA .........T..............A..C..T..............G..............G.....C..A.................G.....C..T..C NPR T..A........C...........A.....T.....C...........C....................A..C..............G.....C.....C UCI A..............T..G.....A..............G.....G..C....................A..C..G..............G..A...... PVI T..C.....T.....A........A.....T.................T...........G..C..C..C..CC.G.....C..T........C...... 910 920 930 940 950 960 970 980 990 1000 . . . . . . . . . . CLU ATGTTTACCGTAGGAATAGATGTAGACACACGAGCATACTTTACGTCCGCCACTATAATTATCGCTATTCCAACGGGAGTAAAAGTATTTAGTTGACTGG CLA ....................C....................C..A.................T...........A.....................T... CSI ...........G........C....................C..A.................T...........A..G....................A. CAU ........T...........C....................C..A.............................A.....................T... CMES ....................C....................C..A..T..T.....G..C..............A.................C...T... CMET ....................C....................C..A.................T.....C.....A.................C...T... CAL ....................C....................C..A.....T..A.....C..............A..............C.....GT... LPI ....................C....................C..A.................T...........A......................... CBR ..A..........................G...........C..A..T..............T...........A.....G...............T... SVE ..A.....T...........C.....T..............C..A..T........G.....T..C........A.....G................... CAD ..A.................C........G..............A........C....................A.................C...T.A. CTH ..A.....T..............G........G...........A..T..T.....G.....T.....C.....A..........C..........T.A. AMI ..A.....N..............N.................N..A..N..N.....N.....T.....N.....A..........N..........T.N. DSE ..A.....T...................................A...........G.....T...........A.....................T... DGY ..A.....T...........C.......................A..T........G.....T...........A.....................T... DVE ..A.....G................................C..A.....T.....G.....T...........A..........C..........T.A. DCU ..A.....T...................................A..T..T...........T...........A.....................T... DGR ..A.....T.............................T..C..A..T..............T...........A.....................T... OME ..A.....T........G..C....................C..A.....T...........T..C........T..G..T........C.......... FZE ........T........G.....G........G........C........T...........T....C......A..G...........C........A. VVU ..A..C..T...........C.....T..............C.....T..T..C.....C..T..C.....T..A..G..T....C...C..C...T.A. VMA ..A..C..T...........C..G..T..............C.................C..T..C.....T..A..G..T....C...C..C...T.A. NPR ..A.....T........G..C.....T..............C..A.....T...........T..C..C..G..T..G..C..G.....C........A. UCI .................G..C....................C.....T..T..A...........C.....T..A..G..............C...T.A. PVI ..A.....T.....G..G..C..C.................C..T..A..............T..A..............T..G.....C..C.....A. 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 . . . . . . . . . . CLU CAACACTTCATGGAGGCAATATTAAATGATCTCCAGCTATGCTATGAGCTTTAGGGTTTATTTTTCTATTTACAGTAGGCGGGCTAACAGGTATTGTCCT CLA ..........C.....T....................C..A........................................................T.. CSI ..........C.............................A.....G.............................C......T.......A........ CAU ..........C...........................................................C..G.................C........ CMES .....A....C.............................A...................................G......T..........C..... CMET ....G.....C.....T..............C........A.............................C.....G.....A...........C..... CAL ..........C.....T...........G..C........A..G................................G..T..AT................ LPI .......C..C.....T.......................A........C.............................T..A........C..C..... CBR ..........C.....T..C...........C.....C........G..CC...................C.....G..T..AT.......A........ SVE ....G.....C.....T..C...........C........A.....G..C..........................G.....................T. CAD ....G.....C.....T....................C..A..............A.......................T...T.......C..C..... CTH ...............................C.....C...........AC...............................AT.......A..C..... AMI .......N.NC.....N..N...........N....NC..N........AN.........................N..N..NN....N..N..N..N.. DSE ..........C.....T..............C.....C...........A..........................G...........G..A.....T.. DGY ..........C.....T..............C.....C...........A.....A....................G..T........G..A.....T.. DVE ..........C.....T..C...........C....TC...........A.....A....................G...........G..G.....T.. DCU .......C..C.....T....................C...........A.....A....................G...........G..A.....T.. DGR .......C..C..........................C..A........A.....A....................G...........G..A.....T.. OME .............G....................G..C........G..C.....A.....C....CG........G..............A.....TT. FZE ...............................C..G..C..AT.G.....CC..........C....C......G..G..T.....G.....C.....TT. VVU ..........C..G....................G..C..A.........C...............C............T........G..C..C..TT. VMA ..........C..G.......................C............C...............C...C..G.....T........G..C..C..TT. NPR ..........C.....T..............C.....C..A........CC..........C.....T..C...........A........C........ UCI ................T..............C..G..C..A.....G...C....A........CT.G..C........T..A..G........C..TT. PVI .T..C........G........C.....G........C..AT.......CC.G..C.....C..C........G.....G..C..C........C..A.. 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 . . . . . . . . . . CLU AGCTAATTCGTCCTTAGACATCGTTCTTCATGATACATATTATGTTGTAGCTCATTTTCACTATGTGCTTTCAATAGGAGCAGTTTTTGCCATTATGGGA CLA ......................................................C....................G..............T..C.....C CSI ........................C........C.......................C.................G.......................G CAU ....................................G................................C.....G........................ CMES ..................T..T........C..C.....C....................T..C..A........G........A.....T......... CMET ..................T..T........C........C....................T..C...........G........A.....T........T CAL ......C......C....T....................C.......................C...........G........A.....T........C LPI .....................T.....C.....C........C........C..C...........A....................C..T.....A... CBR G..C..C.....T.....T..T.................C..C........C...........C....................A........C.....T SVE ......C..A...C....T..T..C........C.................C..............A..............G..A..............C CAD .............C....T..T...........C..G..............C..............A..C..............A..C..T........T CTH .....................T.............................C.....C.....C..A.................A...........A..T AMI ............N.....N..T........................N....N.....C.....C..A.................A...........N..T DSE .....................T...................................C.....C..A.................A..............T DGY ............T.....T..T...................................C.....C..A.................A...........A..T DVE ..................T..T........................A..........C.....C..A.................A..............T DCU ..................T..T...................................C.....C..A.................A..............T DGR ..................T..T...................................C.....C..A.................A..............T OME ......C..A..TC.......T........C..C.....C...........C..C........C..............G.....A.....T..C.....T FZE ...C..C..A..TC.......T..C...........C..C..............C...........A..C...........G..G..............T VVU ...C..C..A........T..............C..G..C..C..C........C..C.....C..T..C..............A.....T..C..A..C VMA ...C..C......C.G...........C.....C..G..C..C........C..C..C.....C..A..C.....G........A.....T.....A..C NPR G.....C...........T..T..C.....C........C...........C..C..C..T.......................A...........A..C UCI ......C.....AC................C.....G.....C........C...........C.....C.................C..T........T PVI ...C..C..A..AC.......T..C........C.....C.....G.....A.....C..T.....TT.A..............A..C..T........T 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 . . . . . . . . . . CLU GGATTTGCCCACTGATTCCCTTTATTCTCAGGTTATACTCTTAACGATACTTGAGCAAAGATTCACTTTACAATTATGTTTGTGGGAGTAAATATAACTT CLA .................................................................................................... CSI ...........................................................A........................................ CAU ....................C........................................................A...................... CMES ....................C.......................T..................................................G.... CMET .........................................C..T....................T.................................. CAL ...........T........C..............C........T..C...........A.......................A................ LPI .....C..............C...........C...........T..C...........A..C...........C........A..G...........C. CBR ........T..T.....T..C...........C..C..C.....T..C..C........A.......................A..G...........C. SVE ..G........T........CC.G.....G..C..C........T..............A........C..............A..G............. CAD ....................C.......................T..............A.......................A................ CTH ..............G..T...C..........C..............C..C..............T...........A.....A................ AMI ..N...........G..N..NC.N........C..............C..N........N.....T........N..A.....A........N....N.. DSE ..G...........G.....CC..........C..............C...........A.....T........C..A.....A........C....... DGY ..G...........G.....CC.G........C..............C...........A.....T........C..A.....A........C....... DVE ..G...........G......C.G........C..............C...........A.....T...........A.....A........C....... DCU ..G...........G......C.G........C..............C...........A.....T........C..A.....A........C....... DGR ..G...........G.....CC.G........C..............C...........A.....T........C..A.....A........C....... OME ..T..C..T..T........CC.G..T..G..A.....C........C..A..G.....A........C.....C..A..C..A..G........G.... FZE ..G.....T...........CC....T.....C..C..C..A..T..C..C........A..C.....C.....C.....C..A..G.....C..G..C. VVU ..G.................CC...................A..T..C..C.....G..A..C..............A.....A..G..G..C....... VMA ....................CC.......N..C..C..C..A..T..C..C........A..C..T........C..A..C..A..G..G..C..G..C. NPR ........T...........CC..........C........C..T..............A.................A.....A.....T.....G.... UCI .....C..T..T........CC.......G...........C..T.....C........A..C.....C..G..C..A..C..A..G..T..C..G..C. PVI .....C.T...T........CC..........C....TA..CG....C...........A........C.....C..A..C..A.....C..C.....A. 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 . . . . . . . . . . CLU TCTTCCCTCGGCATTTCATGGCGTACCCATTTCAACTCGGATTACAGGACGCAACCTCCCCTATTATAGAGGAGCTACTTCATTTTCATGACCACACACT CLA .........A....................................................................................T..G.. CSI .........AA...................................................................................T...T. CAU .........A...............................C....................................................TG.... CMES .......C.AA.................T........T.............................................................. CMET .......C.AA.................T.............................................T...................T..... CAL .......C.AA.................T............................................A.......................... LPI .........AA..C..............C........T...C.......T..T..T........C.........T....C.....C........T...T. CBR .T.......AA..C..............C.........................................A........C..C..C.....T..T...T. SVE ....T..C.AA..C..............C.........................................A........C..C..C.....T..T...T. CAD ....T..C.AA..C..............T...................................C....................C........T..... CTH .........AA..C..T...........C...................................C....................C........T...T. AMI ....N..N.AAN.C..N...........C...................................C.....A...........C..C..C.....T...T. DSE .........AA..C..............T...................................C....................C........T...T. DGY .........AA..C..............T...................................C.................C..C........T...T. DVE ....T..C.AA..C..T...........T...................................C....................C........T...T. DCU .........AA..C..............T...................................C....................C.....T..T...T. DGR .........AA..C..............T............C......................C....................C........T...T. OME .T.......AA..C..............T.......................G.............................C..C..C.....T...T. FZE .T.......AA..C..............T..............................................................T..T...T. VVU .........AA..C..............T.......................G......................................T..T..C.. VMA .........AA..C..............T.............................................T................T..T..C.. NPR .........AA..C..............T..C..............A.................C.....A..A..............C.....T..... UCI ....T..C.A..................T...................................C.........T...................T..GT. PVI ....T..C.AA..C........A.....CC.A...A.A..CC....A..T........T..C............T....A..C..C............T. 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 . . . . . . . . . . CLU AATAATTGTATTCTTAATCAGTTCTTTAGTTCTCTATATCATTTCACTAATATTGACTACAAAATTAACCCATACAAGCACAATAGACGCACAAGAAGTG CLA ....................................C..............G..A.....G......................................A CSI ............................A.......C................................T.............................A CAU ....................................C........C.......................T.......................G.....A CMES G...........T........C...C.............T.....GT.......A.........C....T..C...........G..............A CMET ............T..........................T.....GT.G.....A.........C..................................A CAL .....................C...........T........C...T......................T.............................A LPI .....................C...........T..C..T......T.....C.A....................T...........T...........A CBR G........G..TC..........CC.G........C..T.....CTC......A.........C....T...........G..............G..A SVE G........G..TC..........CC.G........C..T.....CTC......A.........C....T...........G..............G..A CAD .....................C...........T..C..T.....GT.....C.A...........G..T.............................A CTH ......C...........T..C...C.............T......T.....C.A..............T..C..........................A AMI .....................C.................T......T.......A..............T..C..........................A DSE .....................C.................T..C...T.....C.............G..T..C..........................A DGY .....................C.................T......T.....C.A...........G..T..C..........................A DVE ..................T..C........................T.....C.A...........G..T..C..........................A DCU .....................C.................T......T.....C.A...........G..T..C..........................A DGR .....................C.................T......T.....C.A...........G..T..C..........................A OME ......C..............C...C.......T..C..T............C.A.....T...........C..T....................G..A FZE .....................C..AC.......T..C..T...A.CT.....C.A..C..C..G........C.................G.....G..A VVU ......C..............C..A........T..C..T...A.TT.....C.A.....C..GC.............T...........G.....G..A VMA .....................C..A........T.....T...A.CT.......A..C..C..GC....T........T.................G..A NPR ............TC....T..C........C..T..C.................A..C..T...........C..............T...........A UCI ......C.....T........C..A.....C..T........C...........A.....T...C.C..T..C.....T..G.................A PVI .........G...C....T..C..A.....A.....C..T..C.....T...C.A..C..G...C.C.....C.....T..................... 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 . . . . . . . . . . CLU GAAACAGTATGAACCATTCTACCCGCCATTATCCTAATCCTAATCGCTCTACCTTCCCTCCGAATCCTTTATATAATGGACGAAATTAATAACCCCTCTT CLA ..............T..C...........C....................G....................C.....A....................C. CSI ...........G..T..C...........................................................A....................A. CAU ..............T..C...........................................................A........C............C CMES ..............T.................T...........T..A..G.....T..T.................A...........C........C. CMET ..............T..............C..T...........T..A........T..T.................A........C..C........C. CAL ..............T........................T.......A........T.................G..A..............T.....C. LPI ...........G.....C.....................TCG.....A.....C..T..T...........C.....A...........C.......... CBR ..............T..C.....A.....C......G..........GT...................G........A.......C...C.......... SVE ..............T..CT....A.....C......G..........AT...................G........A........C..C.........C CAD .....G........T.................T..............A........T........T..C........A.....G................ CTH ..............T........A............G....G..T..A........T...........C........A...........C.....A..AC AMI ...........G..T..C..G..A..............TT.......A..............G..............A.................A..A. DSE ...........G.....C.....A.........T.............A........T...........C........A.....G........T.....A. DGY ...........G..T..C.....A.........T.............A........T...........C........A.....G..............AC DVE ...........G.....C.....A.........T.............AT.......T...........C........A.....G........T.....A. DCU ........G..G..T..C.....A.........T.............A........T...........C........A.....G..............A. DGR ........G..G..T..C.....A.........T.............A........T...........C........A.....G..............A. OME ..G.....C..............A..T........T..T.....T..G..T..C.....T........C.....G..A...........C.....A..C. FZE ........T...........................G....G..T..C.....C..T..A.....T..C.....G..A........C..C.....G..AC VVU ........C........C.....A.................G..T.....T.....T..A.....T..C..C........T..............A..AC VMA ........C.....A........A..........................G..C..T..A..G..T..C..C.....A..T..............A..AC NPR ..G.....C.....T..C.....A.......................AT...T...A..T........G.....G..A.................A.TC. UCI ........C.....T........A..T........T........T..A.....C..A...........G........A.................T...C PVI .....G..G.....G..C........T..C..TT....T..C..T..C.....A..AT.A........C..C...........G..C........T..C. 1610 1620 1630 1640 1650 1660 1670 1680 1690 1700 . . . . . . . . . . CLU TAACCGTGAAAACAATAGGCCACCAATGATACTGAAGCTATGAATATACTGACTATGAAGACTTAAACTTTGACTCCTACATAATCCCAACACAAGAATT CLA ....................................................T............................................... CSI ....T..A.....G......................................T.........C..................................... CAU ....T.........................................C.....T............................................... CMES ....T.........................................C.............................T.....................C. CMET ....T.....G..............G................................G.................T.....................C. CAL .......A.............................T......................................T.....................C. LPI .......A...........T.....G...........T.............................T...........T.................GC. CBR ....G..............T..T........T.......................C....................T.....G...............C. SVE ....A.........C.G..T..T....................G.....C........G.................T...........C.........C. CAD ....T..............T..T..G.................G..C.....T.......................T....................... CTH .......A.............................T.....G..C..C...........T..............T.....G...............C. AMI .......A.............................T...........C...........T....................G...............C. DSE ....T..A......G...............................C..............T..............T.....G................. DGY ....T..A......................................C..C...........T..............T.....G..T.............. DVE ....T..A.................G....................C..C...........T..............T.....G................. DCU ....T..A.........................................C...........T..............T.....G................. DGR ....T..A......................................C..C...........T..............T.....G................. OME .......A.................G..............C..............C..G.....G.....C..T.....T........C........... FZE .......A.................G.....T........C........................................................... VVU .......A..............T.................C..G..C..............TC.G.................G..T..T........... VMA ....T..A.......................T........C.....C........C......C......................T..C........... NPR .....A.A.................G..............C........C.....C......C....T.....T....................G..G.. UCI .......A........G........G..G.....G...........C..A.....C......C....T........T........T..T..G......C. PVI .G.....A.....T.....A..T..G.................G..C..A.....C......C.G...........A..T..G.....C.........C. 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 . . . . . . . . . . CLU AAAGCCAGGAGAACTGCGACTATTAGAAGTAGACAACCGAGTTGTCCTCCCAATAGAAATAACCATCCGAATACTTATCTCTTCAGAAGACGTTTTGCAT CLA ...............C...........G.............................G.......................................... CSI ...............C..................................................T...........................C..... CAU ...............C.................................................................................... CMES ...............C.............................T.................TG.T........CG.............T...C.A... CMET ...A........G..T...............................................TG.T.............................A... CAL ...............A.............................T.................T........G........A..............A..C LPI ...A...........C............................................G..T..T........CG...................A..C CBR ...A...........A......C......................T...........G.....T.................A...........A..A... SVE ...A...........T........G........T..T........T..G...........G..T..T.....G....................A..A..C CAD ...A...........C..................................................T.....G...G.................C.A... CTH ...A...........C................................T..............AG.T..............C..............A..C AMI ...A........G..C.............................T.................AG.T.............................A..C DSE ...A........G..T.......................G.....T.................AG.T..........................C..A..C DGY ...A........G..T.......................G.....T.................AG.T.............................A..C DVE ...A........G..T..G....................G.....T.................AG.T.............................A..C DCU ...A.T......G..T.......................G.....T.................AG.T.............................A..C DGR ...A........G..T.......................G.....T.................AG.T.............................A..C OME ...A.......................G..C...........C.....T..C........G...G.A..G.................G..T..AC.A..C FZE ...............C...........G.............................G.....T..T..........................A..A..C VVU ...A...........C..............C...........C..T........G........TG.............T..............A.....C VMA ...A.....G..G..T..............T..T...........T..................G............................A..A..C NPR ...A........G..T.....GC.......C.....T.....GA....................G........T.A..............T..AC.A..C UCI ...A...........A..............C..............T..............G...G.......G........C...........A..A..C PVI ......C........A.....GC.............T.....A....................A.....C.....A.....A........T..AC.C..C 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 . . . . . . . . . . CLU TCATGAGCCGTTCCATCACTAGGTCTAAAAACTGACGCTATTCCAGGACGACTAAACCAAACCACCCTTATAGCCATACGACCAGGACTGTACTATGGCC CLA .......................C.................C...........G..............C.......................T....... CSI ..G.....T.............................C...................................T.C...............T....... CAU ........T...............................................T...................................T....... CMES .........................................C.................G........C.....T..............A.......... CMET .........................................C...........G..T.....T...........T..............A.......... CAL ........T..C...........CT....G................................T..........................A..T.....T. LPI ...........C........T....................C..................................C............A..T.....G. CBR ........T..............CT................C...........G..T.....T...........T...........G..A.......... SVE ........T................................C...........G..T.................T.C............A..T.....T. CAD .......................G................................T...........A.....T.......................T. CTH ........T...............................................T.....T..T..C....................A..T.....T. AMI ........T................................C..............T.....T...........T..G...........A..T.....T. DSE ........T.....G..........................C..............T...........C.....T..............A..T.....T. DGY ......CGT................................C..............T...........C.....T..............A..T.....T. DVE ........T................................C..............T.....T.....C.....T..G...........A..T..C..T. DCU ........T................................C..............T...........C.....T...........G..A..T.....T. DGR ........T................................C..............T...........C.....T..............A..T.....T. OME .....G.................C..C.....C.....C..C...........G..T..G........A.................G..T.....C.... FZE .......................C...........T.....C..........................A.....T..............A..T....... VVU .......................CT..........T..C..C.........T....T.....T.....A.....G..G........G..A.....C.... VMA .......................CT..........T..C..C.........T....T.....T.....A.....G...........G..A..T..C.... NPR ...........C...........C..T.....A.....C..C.........T.......G........A....................A.....C.... UCI ..G....................CT.......C.....A..C.........T.G........T..TT.A.....T..G........C..A.....C.... PVI ...........A..G..C.....A...........T.....C....................A.....A...A......................C..T. 1910 1920 1930 1940 1950 1960 1970 1980 1990 2001 . . . . . . . . . . CLU AGTGCTCTGAAATCTGCGGATCTAACCACAGCTTTATACCCATTGTTCTTGAAATAGTCCCCCTATCTTACTTTGAGACCTGATCTGCCTTAATAGTATAA CLA ............................T........G...................................C..A........................ CSI ....T.......................T........G.....C................................A........................ CAU ............................T.........................................T.....A........................ CMES .A..........................T...........T.....C....................C........A..T.........C........... CMET .A..........................T...........T.....C...........A........C........A..T.........C........... CAL .A.....C.................T..T........G..T.....................T..........C..AG...........C........... LPI .A..............T.............................................T..C..........AG....G...A........A..... CBR .A.......................T..............T.....................T....A........A............C........... SVE .A...........T.....G.....T..............T........C.................C.....C..A.................GT....G CAD ......................C..T...........G..T.....................T.G..C........A.................G...... CTH .A....................C.................T.....C..C........T...T....C........A........A........G...... AMI .A....................C...........C.....T..C..............T...T.G..C........A........A........G...... DSE .A....................C........T...........C..............T........C........A..T.....A...G........... DGY .A.A..................C...........C........C.......................C........A........A...G........... DVE .A...........T........C...........C........C..............T........C........A........A...G........... DCU .A...........T.....G..C...........C........C..................T....C..T.....A..T.....A...G........... DGR .A....................C...........C........C.......................C........A........A...G........... OME .A...........T........C..T...........G..T...........G..............A.....C..A..T.....A........G...... FZE .A..........................T...........T..........................A.....C..A............C....G...... VVU .A...........T........C...........C.....G....................A..G..C.....C..A...........TG....G..T... VMA .A...........T........C...........C.....A....................A..G..C.....C..A.................G..T... NPR .A...........T....................C..G.....C..........................T..C..A............C.T......... UCI .A...........T........C..............G.....C....................G..C.....C..A............C....G...... PVI .A.....A........T..T..A...........C.....T.....C..C...T.G.....A.....CC....C....AA......A...C...GC.T... b) 10 20 30 40 50 . . . . . HESPEROCYONINAE 000000000000000000000000000000000000000000000000000000000 BOROPHAGINAE 111000000000000000000000000000000000000000000000000000000 LEPTOCYON 121111111100000000000000000000000000000000000000000000000 VULPES 121111111111111111100000000000000000000000000000000000000 UROCYON 131111111111111121011001001111000000000000000000000000000 OTOCYON 121111111111111121011111111000000000000000000000000000000 "PSEUDOLOPEX" 131111111111111110000000010000111011100000000000000000000 PSEUDOLOPEX 131111111111101110000000010010111011111000000000000000000 LYCALOPEX 131111111111111110000000010001111011110000000000000000000 CHRYSOCYON 131111111111111110000000000001111011110000000011000000000 CERDOCYON 131111111111111110000001001001111011120000000000000000000 NYCTEREUTES 131111111111111110000001011101111011120000000000000000000 ATELOCYNUS 131111111111111110100000010001111011120000000000100000000 SPEOTHOS 031100111111121110100000010001211010120011111100111100000 CANIS 131111111111111110000000000000121110000000001010000011100 CUON 031111011111121110000100001000121110000011111110011011100 LYCAON 031111011111111110000100001000221110001010111110001011111