Geneid S2_1 S2_2 S2_3 Con_1 Con_2 Con_3 logFC logCPM F PValue FDR uniprotAc Refseq pfam interpro eggNOG GO(GO_term,class,description) KEGG(KO,pathway,description) Gm19026 11.0744854052256 11.5948192318726 13.5443915426367 1.13676857879797 1.13899875960947 0.944096534653671 3.51281674241706 4.91228187334471 865.590602936317 1.54421987283332e-11 1.51179125550382e-08 A0A0A0MQE5,Calmodulin-regulated spectrin-associated protein 1 NP_001263288.1,calmodulin-regulated spectrin-associated protein 1 isoform 1 PF17095,Spectrin-binding region of Ca2+-Calmodulin;PF08683,Microtubule-binding calmodulin-regulated spectrin-associated;PF11971,CAMSAP CH domain IPR022613,Calmodulin-regulated spectrin-associated protein, CH domain;IPR011033,PRC-barrel-like superfamily;IPR036872,CH domain superfamily;IPR031372,CAMSAP, spectrin and Ca2+/calmodulin-binding region;IPR038209,CKK domain superfamily;IPR014797,CKK domain;IPR032940,Calmodulin-regulated spectrin-associated protein KOG3654,Uncharacterized CH domain protein;ENOG4111D0B,- GO:0005874,cellular_component,microtubule;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0031113,biological_process,regulation of microtubule polymerization;GO:0005516,molecular_function,calmodulin binding;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0051011,molecular_function,microtubule minus-end binding;GO:0036449,cellular_component,microtubule minus-end;GO:0008017,molecular_function,microtubule binding;GO:0030507,molecular_function,spectrin binding;GO:0031175,biological_process,neuron projection development;GO:0007010,biological_process,cytoskeleton organization - Gm37138 0.86945838267298 1.26037358616445 1.58832728806446 0.381501183098615 0.6174801796351 0.621956936863663 1.20857439535538 0.990282587468676 19.1704424994154 0.00115419515083373 0.00914978598227064 Q7R856,Uncharacterized protein - - - - - - Gm28177 45.6433055126872 47.0769021752684 52.8228740849454 20.8281898639169 18.9773109522103 22.0560436857622 1.2568619618204 6.93915222072282 219.662214007653 2.26115839717595e-08 2.26214868552508e-06 A0A0G2JX93,Signal transducer and activator of transcription - PF12162,STAT1 TAZ2 binding domain;PF02865,STAT protein, protein interaction domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02864,STAT protein, DNA binding domain IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR035859,STAT1, SH2 domain;IPR038295,STAT1, C-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR013799,STAT transcription factor, protein interaction;IPR022752,Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal;IPR001217,Transcription factor STAT;IPR036535,STAT transcription factor, N-terminal domain superfamily - GO:0035035,molecular_function,histone acetyltransferase binding;GO:0051607,biological_process,defense response to virus;GO:0035458,biological_process,cellular response to interferon-beta;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0061326,biological_process,renal tubule development;GO:0043330,biological_process,response to exogenous dsRNA;GO:0009617,biological_process,response to bacterium;GO:0043542,biological_process,endothelial cell migration;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0042393,molecular_function,histone binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0007584,biological_process,response to nutrient;GO:0051770,biological_process,positive regulation of nitric-oxide synthase biosynthetic process;GO:0006351,biological_process,transcription, DNA-templated;GO:0009612,biological_process,response to mechanical stimulus;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010742,biological_process,macrophage derived foam cell differentiation;GO:0033209,biological_process,tumor necrosis factor-mediated signaling pathway;GO:0031730,molecular_function,CCR5 chemokine receptor binding;GO:0005634,cellular_component,nucleus;GO:0042542,biological_process,response to hydrogen peroxide;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0060337,biological_process,type I interferon signaling pathway;GO:0007259,biological_process,JAK-STAT cascade;GO:0031663,biological_process,lipopolysaccharide-mediated signaling pathway;GO:0032496,biological_process,response to lipopolysaccharide;GO:0008015,biological_process,blood circulation;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0071310,biological_process,cellular response to organic substance;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000983,molecular_function,transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0051721,molecular_function,protein phosphatase 2A binding;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0000790,cellular_component,nuclear chromatin;GO:0001047,molecular_function,core promoter binding;GO:0042802,molecular_function,identical protein binding;GO:0014070,biological_process,response to organic cyclic compound;GO:0042493,biological_process,response to drug;GO:0003677,molecular_function,DNA binding;GO:0008150,biological_process,biological_process;GO:0030425,cellular_component,dendrite;GO:0003690,molecular_function,double-stranded DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0030424,cellular_component,axon;GO:0045296,molecular_function,cadherin binding;GO:0034240,biological_process,negative regulation of macrophage fusion;GO:0004871,molecular_function,signal transducer activity;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0035456,biological_process,response to interferon-beta;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000979,molecular_function,RNA polymerase II core promoter sequence-specific DNA binding;GO:0046725,biological_process,negative regulation by virus of viral protein levels in host cell;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0051591,biological_process,response to cAMP;GO:0007165,biological_process,signal transduction;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0019899,molecular_function,enzyme binding;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0060333,biological_process,interferon-gamma-mediated signaling pathway;GO:0008283,biological_process,cell proliferation;GO:0032727,biological_process,positive regulation of interferon-alpha production;GO:0006468,biological_process,protein phosphorylation;GO:0034097,biological_process,response to cytokine;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0070491,molecular_function,repressing transcription factor binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005737,cellular_component,cytoplasm;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0071345,biological_process,cellular response to cytokine stimulus;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0034340,biological_process,response to type I interferon;GO:0043434,biological_process,response to peptide hormone;GO:0071346,biological_process,cellular response to interferon-gamma - Stat1 27.1327475648575 27.4600796354614 30.0332843640466 12.0882944412029 11.444403753896 12.8844842687893 1.23790908263399 7.16985974505429 286.8828378565 4.08713359338549e-09 6.15585198142215e-07 A0A087WSP5,Signal transducer and activator of transcription NP_001192242.1,signal transducer and activator of transcription 1 isoform 1 PF12162,STAT1 TAZ2 binding domain;PF02865,STAT protein, protein interaction domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02864,STAT protein, DNA binding domain IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR035859,STAT1, SH2 domain;IPR038295,STAT1, C-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR013799,STAT transcription factor, protein interaction;IPR022752,Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal;IPR001217,Transcription factor STAT;IPR036535,STAT transcription factor, N-terminal domain superfamily KOG3667,STAT protein;ENOG410XPN8,- GO:0051607,biological_process,defense response to virus;GO:0035458,biological_process,cellular response to interferon-beta;GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0032991,cellular_component,protein-containing complex;GO:0000790,cellular_component,nuclear chromatin;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0042393,molecular_function,histone binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003690,molecular_function,double-stranded DNA binding;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0010742,biological_process,macrophage derived foam cell differentiation;GO:0033209,biological_process,tumor necrosis factor-mediated signaling pathway;GO:0005634,cellular_component,nucleus;GO:0060337,biological_process,type I interferon signaling pathway;GO:0007259,biological_process,JAK-STAT cascade;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000983,molecular_function,transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0005829,cellular_component,cytosol;GO:0001047,molecular_function,core promoter binding;GO:0042802,molecular_function,identical protein binding;GO:0003677,molecular_function,DNA binding;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035035,molecular_function,histone acetyltransferase binding;GO:0045296,molecular_function,cadherin binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035456,biological_process,response to interferon-beta;GO:0004871,molecular_function,signal transducer activity;GO:0000979,molecular_function,RNA polymerase II core promoter sequence-specific DNA binding;GO:0046725,biological_process,negative regulation by virus of viral protein levels in host cell;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0019899,molecular_function,enzyme binding;GO:0060333,biological_process,interferon-gamma-mediated signaling pathway;GO:0005730,cellular_component,nucleolus;GO:0032727,biological_process,positive regulation of interferon-alpha production;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0070491,molecular_function,repressing transcription factor binding;GO:0061326,biological_process,renal tubule development;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0006351,biological_process,transcription, DNA-templated K11220,ko04919,Thyroid hormone signaling pathway;K11220,ko05145,Toxoplasmosis;K11220,ko05164,Influenza A;K11220,ko05162,Measles;K11220,ko05212,Pancreatic cancer;K11220,ko04917,Prolactin signaling pathway;K11220,ko05160,Hepatitis C;K11220,ko04380,Osteoclast differentiation;K11220,ko04630,Jak-STAT signaling pathway;K11220,ko05321,Inflammatory bowel disease (IBD);K11220,ko04620,Toll-like receptor signaling pathway;K11220,ko05168,Herpes simplex infection;K11220,ko04933,AGE-RAGE signaling pathway in diabetic complications;K11220,ko05152,Tuberculosis;K11220,ko05200,Pathways in cancer;K11220,ko05140,Leishmaniasis;K11220,ko04062,Chemokine signaling pathway;K11220,ko05161,Hepatitis B Hecw2 0.183824625418075 0.120638135858204 0.163849100413033 0.0520852213249466 0.0516602597301481 0.0292695743150194 1.79840278739021 0.484068604148451 40.6304297006974 5.75600295228291e-05 0.000865990960087702 D4ADD3,HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 2 XP_017451936.1,-;NP_001101688.1,E3 ubiquitin-protein ligase HECW2 PF16562,N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2;PF00632,HECT-domain (ubiquitin-transferase);PF00168,C2 domain;PF00397,WW domain IPR001202,WW domain;IPR037795,E3 ubiquitin-protein ligase HECW, C2 domain;IPR000569,HECT domain;IPR032348,E3 ubiquitin-protein ligase HECW1/2, N-terminal;IPR035892,C2 domain superfamily;IPR036020,WW domain superfamily;IPR035983,HECT, E3 ligase catalytic domain;IPR000008,C2 domain KOG0940,Ubiquitin protein ligase RSP5/NEDD4;COG5021,Ubiquitin-protein ligase GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0030071,biological_process,regulation of mitotic metaphase/anaphase transition;GO:0016740,molecular_function,transferase activity;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016874,molecular_function,ligase activity;GO:0072686,cellular_component,mitotic spindle;GO:0004842,molecular_function,ubiquitin-protein transferase activity - Aox2 3.00620045237405 3.11630311071285 3.23289536073518 1.40221249799497 1.49839114629115 1.52905829940388 1.09751042897276 3.74522802145534 158.66130848319 8.63706659193077e-08 5.98588878364199e-06 A0A096P6M6,Aldehyde oxidase 2 - PF00111,2Fe-2S iron-sulfur cluster binding domain;PF02738,Molybdopterin-binding domain of aldehyde dehydrogenase;PF01799,[2Fe-2S] binding domain;PF00941,AD binding domain in molybdopterin dehydrogenase;PF03450,CO dehydrogenase flavoprotein C-terminal domain;PF01315,Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain IPR016166,FAD-binding, type 2;IPR000674,Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead;IPR036856,Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily;IPR006058,2Fe-2S ferredoxin, iron-sulphur binding site;IPR016208,Aldehyde oxidase/xanthine dehydrogenase;IPR036884,[2Fe-2S]-binding domain superfamily;IPR002888,[2Fe-2S]-binding;IPR036683,CO dehydrogenase flavoprotein, C-terminal domain superfamily;IPR002346,Molybdopterin dehydrogenase, FAD-binding;IPR014313,Aldehyde oxidase;IPR008274,Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding;IPR037165,Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily;IPR036010,2Fe-2S ferredoxin-like superfamily;IPR036318,FAD-binding, type 2-like superfamily;IPR001041,2Fe-2S ferredoxin-type iron-sulfur binding domain;IPR005107,CO dehydrogenase flavoprotein, C-terminal COG4631,Xanthine dehydrogenase, molybdopterin-binding subunit B;COG4630,Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A;KOG0430,Xanthine dehydrogenase GO:0051287,molecular_function,NAD binding;GO:0046872,molecular_function,metal ion binding;GO:0022900,biological_process,electron transport chain;GO:0016614,molecular_function,oxidoreductase activity, acting on CH-OH group of donors;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0009055,molecular_function,electron transfer activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0051537,molecular_function,2 iron, 2 sulfur cluster binding;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process - Tns1 0.0352079240402221 0.0167242110640439 0.0203848969686978 0.0880698954708075 0.06266508894999 0.037195368655502 -1.37843282022942 -0.342540211412443 11.5391121841307 0.00612441319611008 0.0334027884066394 E9Q0S6,Tensin 1 NP_082160.3,tensin-1 isoform a PF10409,C2 domain of PTEN tumour-suppressor protein;PF00017,SH2 domain;PF08416,Phosphotyrosine-binding domain IPR014020,Tensin phosphatase, C2 domain;IPR036860,SH2 domain superfamily;IPR029021,Protein-tyrosine phosphatase-like;IPR000980,SH2 domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR006020,PTB/PI domain;IPR029023,Tensin-type phosphatase domain;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR033929,Tensin, phosphotyrosine-binding domain;IPR011993,PH-like domain superfamily;IPR035012,Tensin-like, SH2 domain;IPR013625,Tensin/EPS8 phosphotyrosine-binding domain KOG2283,Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases;KOG1930,Focal adhesion protein Tensin, contains PTB domain;COG2453,Predicted protein-tyrosine phosphatase GO:0007044,biological_process,cell-substrate junction assembly;GO:0035556,biological_process,intracellular signal transduction;GO:0030055,cellular_component,cell-substrate junction;GO:0003779,molecular_function,actin binding;GO:0005622,cellular_component,intracellular;GO:0005925,cellular_component,focal adhesion;GO:0010761,biological_process,fibroblast migration - Scg2 0.59767142625204 0.585546880812877 0.756969981206747 0.243754693834839 0.0189958927215628 0.0645759463771467 2.67500646977728 0.0788044034766336 31.3663069385145 0.000175742555004694 0.00207828081009002 Q4W8U9,Scg2 protein NP_001297609.1,secretogranin-2 isoform 2 precursor PF01271,ranin (chromogranin or secretogranin) IPR001990,Chromogranin A/B/C - GO:0001525,biological_process,angiogenesis;GO:0031045,cellular_component,dense core granule;GO:0030141,cellular_component,secretory granule;GO:0098992,cellular_component,neuronal dense core vesicle - Gm7582 4.46622280210247 3.33028133252914 4.51025705457231 1.82997926864066 1.42610955805166 2.06489531132452 1.21955620696349 0.907126466791647 29.0010673535489 0.000237112236683982 0.00263146584290741 A0A0P6D195,Nuclear body SP140-like protein - PF03172,HSR domain IPR004865,HSR domain - GO:0005634,cellular_component,nucleus - Gm2619 31.9713142691598 33.9950236336757 27.5528297516243 10.0301546955926 10.1927634054203 10.3453934337803 1.63289402867888 3.99560517129217 331.505709281899 1.92027214762538e-09 3.60537671991143e-07 A0A0P6D195,Nuclear body SP140-like protein - PF03172,HSR domain IPR004865,HSR domain - GO:0005634,cellular_component,nucleus - Gm7609 8.30563140783428 7.61641745136592 7.10430537879579 3.07012747893941 3.46442920883262 3.27506467360004 1.24268517869436 3.78576230339712 214.710227558868 1.83656188722882e-08 1.87850128554912e-06 Q3U0D6,Uncharacterized protein - - IPR004865,HSR domain;IPR017452,GPCR, rhodopsin-like, 7TM ENOG410YPW5,-;ENOG410J1CI,- GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Gm2666 4.4987463883992 4.10697320783728 3.29658788352376 1.85770622725643 1.9302897048376 1.51897217675387 1.17544866176677 1.41329605332129 45.6177384609283 3.46066578479514e-05 0.000595130304220856 Q921A8,Putative G-protein coupled receptor - - IPR017452,GPCR, rhodopsin-like, 7TM - GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Gm7592 37.3588330839269 39.2877591075782 36.0022097805884 19.9458984400164 19.2013028533845 17.9590478834731 1.00276054808765 4.16056738495378 187.955114489132 3.63967462958196e-08 3.28193292585858e-06 A0A0P6D195,Nuclear body SP140-like protein - PF03172,HSR domain IPR004865,HSR domain - GO:0005634,cellular_component,nucleus - Sp100 13.0550292720609 12.6683796110224 12.4682224107123 6.11744922533013 6.34803717251316 6.45535835229443 1.03173214476211 6.17383950600245 426.349446726814 5.11942254843302e-10 1.3493616432466e-07 Q8C405,Nuclear autoantigen Sp-100 NP_038701.2,nuclear autoantigen Sp-100 isoform 1 PF03172,HSR domain;PF00439,Bromodomain;PF01342,SAND domain IPR036427,Bromodomain-like superfamily;IPR010919,SAND-like domain superfamily;IPR004865,HSR domain;IPR000770,SAND domain;IPR001487,Bromodomain ENOG4111G04,-;KOG2177,Predicted E3 ubiquitin ligase GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus - Tnnt2 0.412045953131546 0.345400695479028 0.435037332926316 0.134439266446189 0.104769013584935 0.174587746321943 1.54295333645523 1.12723603069838 48.8555303034476 2.54772128242141e-05 0.00047187929590362 Q6P3Z7,Tnnt2 protein NP_001123648.1,troponin T, cardiac muscle isoform b;NP_001123646.1,troponin T, cardiac muscle isoform a PF00992,Troponin IPR038077,Troponin domain superfamily;IPR001978,Troponin;IPR027707,Troponin T KOG3634,Troponin;ENOG410XS6A,- GO:0032780,biological_process,negative regulation of ATPase activity;GO:0032972,biological_process,regulation of muscle filament sliding speed;GO:0005523,molecular_function,tropomyosin binding;GO:0051592,biological_process,response to calcium ion;GO:0055010,biological_process,ventricular cardiac muscle tissue morphogenesis;GO:0032781,biological_process,positive regulation of ATPase activity;GO:0030049,biological_process,muscle filament sliding;GO:0031013,molecular_function,troponin I binding;GO:0051764,biological_process,actin crosslink formation;GO:0006937,biological_process,regulation of muscle contraction;GO:0097512,cellular_component,cardiac myofibril;GO:0030016,cellular_component,myofibril;GO:0051291,biological_process,protein heterooligomerization;GO:0005861,cellular_component,troponin complex;GO:0030172,molecular_function,troponin C binding;GO:0030674,molecular_function,protein binding, bridging;GO:0060048,biological_process,cardiac muscle contraction;GO:0003779,molecular_function,actin binding;GO:0005865,cellular_component,striated muscle thin filament;GO:1990584,cellular_component,cardiac Troponin complex;GO:0006936,biological_process,muscle contraction;GO:0008016,biological_process,regulation of heart contraction K12045,ko05410,Hypertrophic cardiomyopathy (HCM);K12045,ko05414,Dilated cardiomyopathy;K12045,ko04261,Adrenergic signaling in cardiomyocytes;K12045,ko04260,Cardiac muscle contraction Gm15850 2.01739629175972 1.93835701179807 1.93789170605386 0.927493152993326 1.00259190745408 0.87188558151477 1.08454549026401 1.62431284160484 58.4582640098812 1.1248547000665e-05 0.00024254780256987 - - - - - - - Rgs1 16.1558550306295 15.5197725596418 18.4548655655939 7.20967577271636 6.56755578465059 7.49661637844921 1.25897644203509 6.3772044136669 207.356247464086 3.1875066671931e-08 2.95188962030734e-06 A0A1U7Q964,regulator of G-protein signaling 1 XP_005073520.1,regulator of G-protein signaling 1 - IPR030409,Regulator of G-protein signalling 1;IPR024066,RGS, subdomain 1/3;IPR016137,RGS domain;IPR036305,RGS domain superfamily - GO:0043547,biological_process,positive regulation of GTPase activity;GO:0008277,biological_process,regulation of G-protein coupled receptor protein signaling pathway;GO:0005096,molecular_function,GTPase activator activity - Ptgs2 42.7066737484132 33.9857391391585 38.9425638769056 4.04233630149292 4.81919162226321 3.88882082900832 3.19377130337927 6.62348559088716 1062.58282028067 9.08815937751425e-12 1.03801927023509e-08 Q3UMR6,Uncharacterized protein - PF03098,Animal haem peroxidase;PF00008,-like domain IPR029576,Prostaglandin G/H synthase 2;IPR019791,Haem peroxidase, animal type;IPR037120,Haem peroxidase domain superfamily, animal type;IPR010255,Haem peroxidase;IPR000742,EGF-like domain ENOG410XPZ3,-;KOG2408,Peroxidase/oxygenase GO:0019371,biological_process,cyclooxygenase pathway;GO:0004666,molecular_function,prostaglandin-endoperoxide synthase activity;GO:0008217,biological_process,regulation of blood pressure;GO:0001516,biological_process,prostaglandin biosynthetic process;GO:0098869,biological_process,cellular oxidant detoxification;GO:0006954,biological_process,inflammatory response;GO:0006979,biological_process,response to oxidative stress;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding;GO:0004601,molecular_function,peroxidase activity - Rgs16 3.82908543705314 3.66316708522059 3.95336853924076 1.04838487386853 0.817010178618735 0.648060160165123 2.21557069335498 2.47763009831605 218.50951317359 1.67772188601456e-08 1.74203455831179e-06 Q542U0,MCG20130, isoform CRA_d NP_035397.2,regulator of G-protein signaling 16 PF00615,Regulator of G protein signaling domain IPR024066,RGS, subdomain 1/3;IPR016137,RGS domain;IPR036305,RGS domain superfamily ENOG410YMJD,-;KOG3589,G protein signaling regulators GO:0005737,cellular_component,cytoplasm;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0031224,cellular_component,intrinsic component of membrane;GO:0005096,molecular_function,GTPase activator activity - Gm28513 3.26948045029664 4.14954140584952 4.61414747808056 1.40009833114595 0.545550883137216 0.706507907073514 2.25379869299987 0.693533273966728 54.0298520141694 1.6149683569558e-05 0.00032219441485351 Q542U0,MCG20130, isoform CRA_d NP_035397.2,regulator of G-protein signaling 16 PF00615,Regulator of G protein signaling domain IPR024066,RGS, subdomain 1/3;IPR016137,RGS domain;IPR036305,RGS domain superfamily ENOG410YMJD,-;KOG3589,G protein signaling regulators GO:0005737,cellular_component,cytoplasm;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0031224,cellular_component,intrinsic component of membrane;GO:0005096,molecular_function,GTPase activator activity - Tor3a 53.0078273847707 52.6634534810136 49.9633807243982 25.9897492482303 26.2809786451485 26.122231299259 1.00853567582836 7.25009832931278 475.154857136812 2.88967319956679e-10 8.60996975505704e-08 A0A1U7QFS1,torsin-3A XP_005071369.1,- - IPR010448,Torsin;IPR001270,ClpA/B family;IPR030552,Torsin-3A;IPR027417,P-loop containing nucleoside triphosphate hydrolase - GO:0005524,molecular_function,ATP binding - Selp 0.198693357866288 0.262920919160016 0.320470474061113 0.097242270223484 0.151562515913489 0.073604579713811 1.2731915840505 -0.106530138401074 14.4864391726288 0.0030150725958141 0.0194377163679342 F1LNV1,p-selectin - PF00084,Sushi repeat (SCR repeat);PF00059,Lectin C-type domain IPR016187,C-type lectin fold;IPR018378,C-type lectin, conserved site;IPR016186,C-type lectin-like/link domain superfamily;IPR033991,Selectin, C-type lectin-like domain;IPR035976,Sushi/SCR/CCP superfamily;IPR000436,Sushi/SCR/CCP domain;IPR001304,C-type lectin-like;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR002396,Selectin superfamily ENOG410Y5JF,-;ENOG410IS44,- GO:0007155,biological_process,cell adhesion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Gm16587 1.66919194918643 1.91327170876935 1.38662966595495 0.92347157762805 0.608947128785673 0.627302066969965 1.24859772540352 0.182741374931809 22.1828872969962 0.000674828738516966 0.00598266668183282 Q3UWM1,Uncharacterized protein - PF00084,Sushi repeat (SCR repeat) IPR002396,Selectin superfamily;IPR000436,Sushi/SCR/CCP domain;IPR035976,Sushi/SCR/CCP superfamily ENOG410Y5JF,-;ENOG410IS44,- GO:0007155,biological_process,cell adhesion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Ifi214 0.494434813379016 0.511927543678033 0.503210497824183 0.0756189780430025 0.100181249945778 0.0333885336002886 2.83868004373914 1.28892001436316 130.750485013237 2.29285902888233e-07 1.25202891832117e-05 E9PVL3,Interferon-activated gene 214 - PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain;IPR004021,HIN-200/IF120x - - - Ifi209 4.22013120534616 3.83728779420541 4.37051156534267 0.967871753022238 1.29302744254134 0.641025957693638 2.09865230186817 3.20281520159452 145.647020481728 1.74743500378528e-07 1.01056304480511e-05 E9PVL3,Interferon-activated gene 214 - PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain;IPR004021,HIN-200/IF120x - - - Ifi208 0.786611798632859 0.908650309149435 0.797015205712071 0.139990802282311 0.18182557638337 0.133923917970239 2.45477414617485 1.43700057425135 176.224293474199 5.06077493734498e-08 4.1784928488705e-06 D3Z5G0,Interferon-activated gene 213 XP_011237154.1,uncharacterized protein LOC623121 isoform X3 PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain - GO:0001047,molecular_function,core promoter binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005730,cellular_component,nucleolus;GO:0003690,molecular_function,double-stranded DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0005829,cellular_component,cytosol;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus - Ifi207 34.5810838643098 31.7033981193959 31.8142985806082 8.52378163221479 8.60520488712899 9.62662689655715 1.89179077855895 6.18601937715343 871.107933723509 1.15630282248266e-11 1.21909896038057e-08 E9Q3L4,Interferon-activated gene 207 NP_001191839.1,uncharacterized protein LOC226691 PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain;IPR004021,HIN-200/IF120x ENOG410J5NP,-;ENOG410Y78B,- GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005730,cellular_component,nucleolus;GO:0003690,molecular_function,double-stranded DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0005829,cellular_component,cytosol;GO:0001047,molecular_function,core promoter binding;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus - Ifi204 18.9598993811633 19.2363259558528 20.911253975562 4.94084124637619 4.74929324597995 4.88000843859086 2.04259609526884 5.46145942811775 809.123118506909 1.71371807414598e-11 1.56588132828298e-08 E9QKL6,Interferon-activable protein 204 NP_032355.2,interferon-activable protein 204 PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain;IPR004021,HIN-200/IF120x ENOG410J5NP,-;ENOG410Y78B,- - - Gm38050 11.5788375400999 9.18765849974215 6.62780379103411 3.34855450207146 1.40513735866854 1.81970313880699 2.10035181782883 0.533208484511112 43.1237850358758 4.43649035012482e-05 0.000715371020456597 - - - - - - - Ifi211 41.0171548011418 42.0257250015417 48.0249139065276 17.9276456418595 17.2898806419025 20.1987048407576 1.26411280575166 5.80292012034764 190.730384195631 4.83334887504537e-08 4.01490179887102e-06 E9QKL6,Interferon-activable protein 204 NP_032355.2,interferon-activable protein 204 PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain;IPR004021,HIN-200/IF120x ENOG410J5NP,-;ENOG410Y78B,- - - Ifi203 27.9812750802984 25.9995351665619 26.8886244794275 11.0797522018115 10.785990258697 11.6974810590377 1.28775988532264 7.00426257481456 524.994202311009 1.70520469542939e-10 6.03705637766197e-08 E9QAN9,Interferon-activable protein 203 NP_001289578.1,interferon-activable protein 203 isoform 1;XP_011237064.1,- PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain IPR004020,DAPIN domain;IPR011029,Death-like domain superfamily;IPR004021,HIN-200/IF120x - - - Ifi202b 78.5747594584522 72.5530341970547 77.439705002234 19.3630570110263 18.439840293193 19.7467815126196 2.00970897887015 6.34660061062209 1133.57156223626 2.8336303667266e-12 6.47295630105914e-09 A0A1Z3MHY1,Ifi202a - - IPR004021,HIN-200/IF120x - - - A430105J06Rik 0.933324480505024 0.560009660936664 0.853234511029678 0.240409041174361 0.112410988693484 0.551976618771454 1.37087229243185 -0.339091592722803 8.97843254905727 0.0124049093580296 0.0565984313119688 - - - - - - - Kcnk2 0.747567895545965 0.577796736956704 0.682259640874935 0.173631453973795 0.280288374599876 0.284754274300467 1.42182151958602 1.24653770728514 46.0039049633671 3.33343750264914e-05 0.000579063300523563 A0A0N8ET34,Potassium channel subfamily K member 2 isoform a - PF07885,Ion channel IPR003976,Two pore domain potassium channel, TREK;IPR013099,Potassium channel domain;IPR003280,Two pore domain potassium channel - GO:0071805,biological_process,potassium ion transmembrane transport;GO:0006811,biological_process,ion transport;GO:0005267,molecular_function,potassium channel activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Cenpf 9.33397688166841 8.3306449138094 11.8317664201596 20.5526130145932 20.2515319389572 22.2009855293142 -1.07243397801291 7.89341200545404 73.7570150469656 9.29856423421513e-06 0.000213120604338048 E9Q3P4,Centromere protein F NP_001074832.2,centromere protein F PF10481,Cenp-F N-terminal domain;PF10490,Rb-binding domain of kinetochore protein Cenp-F/LEK1;PF10473,Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IPR018463,Centromere protein Cenp-F, N-terminal;IPR019513,Centromere protein Cenp-F, leucine-rich repeat-containing domain;IPR018302,Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain ENOG410IGJF,-;ENOG410XS5F,- GO:0010389,biological_process,regulation of G2/M transition of mitotic cell cycle;GO:0000775,cellular_component,chromosome, centromeric region;GO:0097539,cellular_component,ciliary transition fiber;GO:0008134,molecular_function,transcription factor binding;GO:0016363,cellular_component,nuclear matrix;GO:0005635,cellular_component,nuclear envelope;GO:0005634,cellular_component,nucleus;GO:0005737,cellular_component,cytoplasm;GO:0021591,biological_process,ventricular system development;GO:0042803,molecular_function,protein homodimerization activity;GO:0000776,cellular_component,kinetochore;GO:0000278,biological_process,mitotic cell cycle;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:0005654,cellular_component,nucleoplasm;GO:0001822,biological_process,kidney development;GO:0000922,cellular_component,spindle pole;GO:0030496,cellular_component,midbody;GO:0016202,biological_process,regulation of striated muscle tissue development;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000940,cellular_component,condensed chromosome outer kinetochore;GO:0051310,biological_process,metaphase plate congression;GO:0007059,biological_process,chromosome segregation;GO:0045120,cellular_component,pronucleus;GO:0005930,cellular_component,axoneme;GO:0015031,biological_process,protein transport;GO:0005819,cellular_component,spindle;GO:0070840,molecular_function,dynein complex binding;GO:0008022,molecular_function,protein C-terminus binding - Atf3 39.1370963988344 36.6702008565117 41.1361826496255 12.6080814003072 13.1524509867573 12.541294346042 1.62925130028166 5.80913788814141 606.838391495843 7.91259389007309e-11 3.73965558128765e-08 Q4FJW1,Activating transcription factor 3 NP_031524.2,cyclic AMP-dependent transcription factor ATF-3 PF00170,bZIP transcription factor IPR000837,AP-1 transcription factor;IPR029812,cAMP-dependent transcription factor ATF-3;IPR004827,Basic-leucine zipper domain KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,- GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006094,biological_process,gluconeogenesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:1990622,cellular_component,CHOP-ATF3 complex;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0042802,molecular_function,identical protein binding;GO:0010628,biological_process,positive regulation of gene expression;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005730,cellular_component,nucleolus;GO:1903984,biological_process,positive regulation of TRAIL-activated apoptotic signaling pathway;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:1990440,biological_process,positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0034198,biological_process,cellular response to amino acid starvation K09032,ko05166,HTLV-I infection Txlnb 1.84342651706235 1.72697837560041 1.72945085640895 0.957879773429096 0.737799230841587 0.668833475618921 1.19283136628956 2.83741863190582 90.4313651918703 1.41819435343503e-06 4.8961641834208e-05 A0A0G2K2T1,Taxilin beta XP_006227719.1,beta-taxilin isoform X1 PF09728,Myosin-like coiled-coil protein IPR026183,Taxilin family - GO:0005737,cellular_component,cytoplasm;GO:0019905,molecular_function,syntaxin binding - Tnfaip3 2.78225105801196 2.86553518033949 2.82281172561628 1.39135152254522 1.51403258712888 1.20618919306681 1.06117731941518 3.93528103470822 142.927862852855 1.4651449479127e-07 8.73098985047452e-06 Q3U695,Uncharacterized protein - PF02338,OTU-like cysteine protease;PF01754,A20-like zinc finger IPR002653,Zinc finger, A20-type;IPR003323,OTU domain;IPR033478,A20 peptidase ENOG41117NJ,-;ENOG410IQZK,- GO:0003677,molecular_function,DNA binding;GO:0016579,biological_process,protein deubiquitination;GO:0008270,molecular_function,zinc ion binding;GO:0016567,biological_process,protein ubiquitination - Eya4 0.478099121190802 0.606791240884007 0.519023855707462 0.219361780174602 0.22793258680692 0.271197408389711 1.18687321415636 0.799671446749687 32.8362444131838 0.000142479874002048 0.00176248118508309 Q8BY78,Eyes absent homolog NP_001334301.1,eyes absent homolog 4 isoform 2;NP_034297.2,eyes absent homolog 4 isoform 1 PF00702,haloacid dehalogenase-like hydrolase IPR028472,Eyes absent family;IPR028478,Eyes absent homologue 4;IPR006545,EYA domain;IPR038102,EYA domain superfamily KOG3107,Predicted haloacid dehalogenase-like hydrolase (eyes absent);ENOG410XT12,- GO:0016787,molecular_function,hydrolase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0007605,biological_process,sensory perception of sound;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006470,biological_process,protein dephosphorylation;GO:0048839,biological_process,inner ear development;GO:0008134,molecular_function,transcription factor binding;GO:0007275,biological_process,multicellular organism development - Cd24a 2.64603773313312 2.49074064311947 2.02395163081459 6.62941908308137 7.16620052920958 6.50473340994088 -1.48666188632102 3.56929789927113 234.340376966983 1.16887742556907e-08 1.35768084702116e-06 A0A1L1SQ70,CD24a antigen - - IPR028029,Signal transducer CD24 - GO:0007155,biological_process,cell adhesion - Egr2 0.737268803719777 0.656647584695269 0.57627227863835 0.234536777955564 0.309312167240751 0.207113063252973 1.38262153759151 0.722937100140562 40.5724476669331 5.79184591257632e-05 0.000870428071028191 Q3U207,Early growth response 2, isoform CRA_c NP_034248.2,E3 SUMO-protein ligase EGR2 isoform 1;NP_001334387.1,E3 SUMO-protein ligase EGR2 isoform 2 PF00096,Zinc finger, C2H2 type;PF11928,omain of unknown function (DUF3446) IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR021849,Early growth response protein KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0007611,biological_process,learning or memory;GO:0003677,molecular_function,DNA binding;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0071837,molecular_function,HMG box domain binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0032868,biological_process,response to insulin;GO:0046872,molecular_function,metal ion binding;GO:0048168,biological_process,regulation of neuronal synaptic plasticity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm K12496,ko05166,HTLV-I infection;K12496,ko05203,Viral carcinogenesis;K12496,ko05161,Hepatitis B Rtkn2 0.112909653643402 0.112630390838736 0.0588358032213542 0.221035895076481 0.189479492389413 0.234228959997871 -1.13733208160296 -0.05653205754786 15.1320989407474 0.00261277016221614 0.0173837999239487 E9QP76,Rhotekin-2 NP_001074815.1,rhotekin-2 PF08174,Cell division protein anillin;PF00169,PH domain IPR030469,Rhotekin-2;IPR012966,Anillin homology domain;IPR011072,HR1 rho-binding domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily ENOG410IIHF,-;ENOG410ZX8Y,- GO:0030097,biological_process,hemopoiesis;GO:0007165,biological_process,signal transduction - Tmem26 0.334726166201874 0.512330691140468 0.452204157419233 0.182019909440208 0.264784395378554 0.182168420912834 1.06697131466289 0.805966101478917 19.2541970879283 0.00113624045935049 0.0090489899685403 D4ADJ8,Transmembrane protein 26 NP_001101093.1,transmembrane protein 26 PF09772,Transmembrane protein 26 IPR019169,Transmembrane protein 26 ENOG410XS6J,-;KOG4610,Uncharacterized conserved protein GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Gstt4 0.823258648521674 1.48902973229968 1.70495925421881 0.681847685029407 0.386448292778407 0.273691447823599 1.65357139116394 0.00090519044057564 18.302811280077 0.00136152410818909 0.0104543694268009 A0A1U7QC56,glutathione S-transferase theta-4 XP_005070804.1,glutathione S-transferase theta-4 - IPR004045,Glutathione S-transferase, N-terminal;IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR010987,Glutathione S-transferase, C-terminal-like;IPR036249,Thioredoxin-like superfamily - GO:0016740,molecular_function,transferase activity - Gadd45b 15.5340673389119 13.8882727671571 13.7917675553583 6.39191810894866 6.41524007354201 5.08862878132816 1.28753316410101 3.70299784844329 175.720350527109 5.13531687806948e-08 4.18956268635835e-06 Q5U3Z2,Growth arrest and DNA-damage-inducible 45 beta NP_001008322.1,growth arrest and DNA damage-inducible protein GADD45 beta PF01248,Ribosomal protein L7Ae/L30e/S12e/Gadd45 family IPR029064,50S ribosomal protein L30e-like;IPR004038,Ribosomal protein L7Ae/L30e/S12e/Gadd45;IPR024824,Growth arrest and DNA damage-inducible protein GADD45 ENOG410IH6M,-;ENOG4111K8B,- GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0000185,biological_process,activation of MAPKKK activity;GO:0005737,cellular_component,cytoplasm;GO:1900745,biological_process,positive regulation of p38MAPK cascade;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0051726,biological_process,regulation of cell cycle;GO:0006950,biological_process,response to stress;GO:0000186,biological_process,activation of MAPKK activity;GO:0005634,cellular_component,nucleus;GO:0043065,biological_process,positive regulation of apoptotic process K04402,ko04210,Apoptosis;K04402,ko04010,MAPK signaling pathway;K04402,ko04110,Cell cycle;K04402,ko04068,FoxO signaling pathway;K04402,ko04115,p53 signaling pathway Phlda1 12.6966214238412 11.9406821836623 12.1614939403737 1.94616842855435 2.40498339755786 2.03777867369576 2.53359647830437 4.00463990875877 767.755145215102 2.26636177058408e-11 1.82722084868385e-08 F1LNT5,Pleckstrin homology-like domain family A member 1 NP_058876.2,pleckstrin homology-like domain family A member 1 - IPR001849,Pleckstrin homology domain ENOG4111IXF,-;ENOG410IXHQ,- GO:0045210,biological_process,FasL biosynthetic process;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus - Gm28592 19.1020277759445 18.2477844349997 16.4428998886691 2.9783468258848 3.28813519558874 2.77621376305169 2.58198420995089 2.98110745665835 530.892872828228 1.60727419836853e-10 5.95386490887542e-08 A0A1U7Q8W6,pleckstrin homology-like domain family A member 1 XP_005068122.1,pleckstrin homology-like domain family A member 1 - IPR001849,Pleckstrin homology domain - - - Il23a 8.8946137461862 8.86604699123651 10.0862490211124 3.6538990032792 3.65604540121558 3.983529682083 1.32151218443536 3.17117449226281 144.160426984502 1.40302500392958e-07 8.47130427482768e-06 G3HRP0,Interleukin-23 subunit alpha XP_007644861.1,interleukin-23 subunit alpha isoform X1 PF16649,Interleukin 23 subunit alpha IPR009079,Four-helical cytokine-like, core;IPR010831,Interleukin-23 alpha - GO:0032819,biological_process,positive regulation of natural killer cell proliferation;GO:0090023,biological_process,positive regulation of neutrophil chemotaxis;GO:0032760,biological_process,positive regulation of tumor necrosis factor production;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:0042509,biological_process,regulation of tyrosine phosphorylation of STAT protein;GO:0042531,biological_process,positive regulation of tyrosine phosphorylation of STAT protein;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:2000330,biological_process,positive regulation of T-helper 17 cell lineage commitment;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0043382,biological_process,positive regulation of memory T cell differentiation;GO:0006955,biological_process,immune response;GO:0045672,biological_process,positive regulation of osteoclast differentiation;GO:0042104,biological_process,positive regulation of activated T cell proliferation;GO:0070743,cellular_component,interleukin-23 complex;GO:0051142,biological_process,positive regulation of NK T cell proliferation;GO:0045519,molecular_function,interleukin-23 receptor binding;GO:0010536,biological_process,positive regulation of activation of Janus kinase activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0051135,biological_process,positive regulation of NK T cell activation;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0050829,biological_process,defense response to Gram-negative bacterium;GO:0002827,biological_process,positive regulation of T-helper 1 type immune response;GO:0032733,biological_process,positive regulation of interleukin-10 production;GO:0005125,molecular_function,cytokine activity;GO:0032740,biological_process,positive regulation of interleukin-17 production;GO:0042098,biological_process,T cell proliferation;GO:0032725,biological_process,positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0001916,biological_process,positive regulation of T cell mediated cytotoxicity;GO:0032735,biological_process,positive regulation of interleukin-12 production;GO:0032729,biological_process,positive regulation of interferon-gamma production;GO:2000318,biological_process,positive regulation of T-helper 17 type immune response;GO:0032693,biological_process,negative regulation of interleukin-10 production K05426,ko05323,Rheumatoid arthritis;K05426,ko05133,Pertussis;K05426,ko04630,Jak-STAT signaling pathway;K05426,ko04060,Cytokine-cytokine receptor interaction;K05426,ko05152,Tuberculosis;K05426,ko05321,Inflammatory bowel disease (IBD) Osbp2 17.6934255340612 16.8302502569221 15.5202901496349 5.2813644731497 5.51275081322625 5.0297870637147 1.67847379109562 6.13191635166409 959.566225758536 6.90206890365217e-12 9.45997563934567e-09 D3ZHG4,Oxysterol-binding protein - PF01237,Oxysterol-binding protein;PF00169,PH domain IPR000648,Oxysterol-binding protein;IPR037239,Oxysterol-binding protein superfamily;IPR001849,Pleckstrin homology domain;IPR018494,Oxysterol-binding protein, conserved site;IPR011993,PH-like domain superfamily ENOG410XP9E,-;KOG1737,Oxysterol-binding protein GO:0007286,biological_process,spermatid development;GO:0006869,biological_process,lipid transport;GO:0015485,molecular_function,cholesterol binding;GO:0097440,cellular_component,apical dendrite - Lif 2.8219938013092 1.99020674759603 2.93851023410652 0.112743550343838 0.230636338871113 0.124450961791972 4.00303599379451 2.60707818764089 239.361962805872 1.50088788483673e-08 1.61977711413955e-06 Q3U1H5,Uncharacterized protein - PF01291,LIF / OSM family IPR009079,Four-helical cytokine-like, core;IPR001581,Leukemia inhibitory factor /oncostatin;IPR019827,Leukemia inhibitory factor /oncostatin, conserved site;IPR003624,Leukemia inhibitory factor ENOG410ITBQ,-;ENOG410YVPP,- GO:0006955,biological_process,immune response;GO:0005146,molecular_function,leukemia inhibitory factor receptor binding;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005576,cellular_component,extracellular region;GO:0005125,molecular_function,cytokine activity - Upp1 9.1662889645133 8.87508936450651 9.37535473044977 0.969114467355087 1.21812009675499 1.68399095928097 2.83113362182258 3.37739389249482 378.238194931892 9.61388072480157e-10 1.99648256385046e-07 Q5SUC8,Uridine phosphorylase NP_001152873.1,-;XP_006514730.1,-;NP_033503.2,uridine phosphorylase 1;NP_001152874.1,- PF01048,Phosphorylase superfamily IPR010059,Uridine phosphorylase, eukaryotic;IPR035994,Nucleoside phosphorylase superfamily;IPR000845,Nucleoside phosphorylase domain;IPR018016,Nucleoside phosphorylase, conserved site COG2820,Uridine phosphorylase;KOG3728,Uridine phosphorylase GO:0042149,biological_process,cellular response to glucose starvation;GO:0006218,biological_process,uridine catabolic process;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0044206,biological_process,UMP salvage;GO:0009116,biological_process,nucleoside metabolic process;GO:0006220,biological_process,pyrimidine nucleotide metabolic process;GO:0005737,cellular_component,cytoplasm;GO:0009166,biological_process,nucleotide catabolic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0016763,molecular_function,transferase activity, transferring pentosyl groups;GO:0046108,biological_process,uridine metabolic process;GO:0004850,molecular_function,uridine phosphorylase activity;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm K00757,ko00983,Drug metabolism - other enzymes;K00757,ko00240,Pyrimidine metabolism Mir146 238.961296142258 250.590861498462 282.01041425129 96.200602476079 106.574264280553 110.770929145762 1.31708844465139 3.57476059659193 146.029213196954 1.3146906594702e-07 8.1534616193206e-06 - - - - - - - Irgm1 10.564262509204 10.1387291238856 9.6991176042952 4.3261213863648 4.07852606137458 3.7643738425682 1.34140204309131 5.37252864020838 519.676361059331 1.79960724720403e-10 6.03705637766197e-08 A0A1G5SJL2,Immunity related GTPase family M member 1 - - IPR030385,IRG-type guanine nucleotide-binding (G) domain;IPR007743,Immunity-related GTPases-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase - GO:0005525,molecular_function,GTP binding;GO:0016020,cellular_component,membrane - Gm5431 0.810862051734788 0.797301429325852 0.816891404591464 0.238105795570153 0.321631648126099 0.392494229576961 1.35032567162941 1.19537530164976 47.9876819553282 2.76099970763757e-05 0.000501886763831308 Q5NCB3,Predicted gene 5431 - PF05049,Interferon-inducible GTPase (IIGP) IPR030385,IRG-type guanine nucleotide-binding (G) domain;IPR007743,Immunity-related GTPases-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase ENOG410IJSM,-;ENOG41125KF,- GO:0035458,biological_process,cellular response to interferon-beta;GO:0005525,molecular_function,GTP binding;GO:0006952,biological_process,defense response;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0005789,cellular_component,endoplasmic reticulum membrane - Olfr56 1.10435944238034 1.27867535403698 1.47463634772128 0.540483187123316 0.589680742981025 0.5608110896709 1.21096959817032 2.11292636917505 59.9797463856232 9.98802455587083e-06 0.000225528607187423 D3ZNH9,Olfactory receptor NP_999999.1,olfactory receptor Olr1386;XP_006246238.1,- PF13853,Olfactory receptor IPR017452,GPCR, rhodopsin-like, 7TM;IPR000725,Olfactory receptor;IPR000276,G protein-coupled receptor, rhodopsin-like ENOG410IJNK,-;ENOG4111BJF,- GO:0050896,biological_process,response to stimulus;GO:0004984,molecular_function,olfactory receptor activity;GO:0007608,biological_process,sensory perception of smell;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0050911,biological_process,detection of chemical stimulus involved in sensory perception of smell;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane K04257,ko04740,Olfactory transduction Slc22a4 0.466113870992521 0.489432650201697 0.596562319697601 0.240126539363346 0.168418343812211 0.339278767752498 1.08362688481077 0.121359569199902 13.3214865828539 0.00394459676461329 0.0239967346896537 A0A1A6HP21,Uncharacterized protein - PF00083,Sugar (and other) transporter IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain;IPR005829,Sugar transporter, conserved site;IPR005828,Major facilitator, sugar transporter-like - GO:0055085,biological_process,transmembrane transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Csf2 79.5413507925137 79.3223059188453 100.220392393977 6.28369131369487 7.70366556890029 7.98508483597742 3.57238933254729 5.24392172968742 633.598393226463 5.06820742006464e-10 1.3493616432466e-07 Q5SX78,Colony stimulating factor 2 NP_034099.2,granulocyte-macrophage colony-stimulating factor precursor PF01109,ranulocyte-macrophage colony-stimulating factor IPR009079,Four-helical cytokine-like, core;IPR000773,Granulocyte-macrophage colony-stimulating factor ENOG411164J,-;ENOG410JBQ7,- GO:0008083,molecular_function,growth factor activity;GO:0032747,biological_process,positive regulation of interleukin-23 production;GO:0042531,biological_process,positive regulation of tyrosine phosphorylation of STAT protein;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0030223,biological_process,neutrophil differentiation;GO:0006955,biological_process,immune response;GO:0071803,biological_process,positive regulation of podosome assembly;GO:0030224,biological_process,monocyte differentiation;GO:0010744,biological_process,positive regulation of macrophage derived foam cell differentiation;GO:0043011,biological_process,myeloid dendritic cell differentiation;GO:0042127,biological_process,regulation of cell proliferation;GO:0010628,biological_process,positive regulation of gene expression;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0010468,biological_process,regulation of gene expression;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0045918,biological_process,negative regulation of cytolysis;GO:0097028,biological_process,dendritic cell differentiation;GO:0005125,molecular_function,cytokine activity;GO:0005129,molecular_function,granulocyte macrophage colony-stimulating factor receptor binding;GO:0001892,biological_process,embryonic placenta development;GO:0045740,biological_process,positive regulation of DNA replication;GO:0097011,biological_process,cellular response to granulocyte macrophage colony-stimulating factor stimulus K05427,ko04640,Hematopoietic cell lineage;K05427,ko04060,Cytokine-cytokine receptor interaction;K05427,ko05202,Transcriptional misregulation in cancer;K05427,ko04664,Fc epsilon RI signaling pathway;K05427,ko05146,Amoebiasis;K05427,ko04650,Natural killer cell mediated cytotoxicity;K05427,ko04668,TNF signaling pathway;K05427,ko05132,Salmonella infection;K05427,ko05323,Rheumatoid arthritis;K05427,ko04630,Jak-STAT signaling pathway;K05427,ko04660,T cell receptor signaling pathway;K05427,ko05166,HTLV-I infection Gm12223 9.37092387349168 7.77570232337485 8.34448808016951 0.464426556814107 0.814340969228361 0.512653109654431 3.78049859925781 1.33056479425243 269.1263736456 5.700485738926e-09 7.85727130313365e-07 Q14AD9,Colony stimulating factor 2 - PF01109,ranulocyte-macrophage colony-stimulating factor IPR009079,Four-helical cytokine-like, core;IPR000773,Granulocyte-macrophage colony-stimulating factor ENOG411164J,-;ENOG410JBQ7,- GO:0006955,biological_process,immune response;GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005129,molecular_function,granulocyte macrophage colony-stimulating factor receptor binding;GO:0005576,cellular_component,extracellular region - Igtp 10.4075227093642 11.2557579755213 11.997819107246 4.97225821063887 5.38705479940581 5.06020564971662 1.14670021555136 4.06266471977803 160.444233804599 8.16059312843168e-08 5.82853934652944e-06 Q9DCE9,Interferon gamma-induced GTPase NP_061208.3,interferon gamma induced GTPase PF05049,Interferon-inducible GTPase (IIGP) IPR030385,IRG-type guanine nucleotide-binding (G) domain;IPR007743,Immunity-related GTPases-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase - GO:0035458,biological_process,cellular response to interferon-beta;GO:0005525,molecular_function,GTP binding;GO:0006952,biological_process,defense response;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol;GO:0005789,cellular_component,endoplasmic reticulum membrane K14140,ko05145,Toxoplasmosis Irgm2 9.0466978154215 8.22371910623456 8.77079987709878 3.88759010484394 3.7287547469058 3.85848571376981 1.20093210983419 4.53848388002399 295.818042069399 3.48294733254428e-09 5.73050043549715e-07 A0A140LIF8,Immunity-related GTPase family M member 2 - PF05049,Interferon-inducible GTPase (IIGP) IPR030385,IRG-type guanine nucleotide-binding (G) domain;IPR007743,Immunity-related GTPases-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase - GO:0019901,molecular_function,protein kinase binding;GO:0005525,molecular_function,GTP binding;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0000045,biological_process,autophagosome assembly;GO:0061739,biological_process,protein lipidation involved in autophagosome assembly;GO:0061635,biological_process,regulation of protein complex stability;GO:0020003,cellular_component,symbiont-containing vacuole;GO:0005794,cellular_component,Golgi apparatus;GO:0050821,biological_process,protein stabilization;GO:0016020,cellular_component,membrane;GO:0034341,biological_process,response to interferon-gamma;GO:0075044,biological_process,autophagy of host cells involved in interaction with symbiont;GO:0071902,biological_process,positive regulation of protein serine/threonine kinase activity;GO:0061762,biological_process,CAMKK-AMPK signaling cascade;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0042742,biological_process,defense response to bacterium;GO:0010508,biological_process,positive regulation of autophagy;GO:0005739,cellular_component,mitochondrion;GO:0050700,molecular_function,CARD domain binding;GO:0060335,biological_process,positive regulation of interferon-gamma-mediated signaling pathway;GO:0003924,molecular_function,GTPase activity;GO:0000139,cellular_component,Golgi membrane;GO:0043254,biological_process,regulation of protein complex assembly;GO:0043539,molecular_function,protein serine/threonine kinase activator activity;GO:0050829,biological_process,defense response to Gram-negative bacterium;GO:0042832,biological_process,defense response to protozoan;GO:0098586,biological_process,cellular response to virus;GO:0045087,biological_process,innate immune response;GO:0031648,biological_process,protein destabilization;GO:0070431,biological_process,nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0010800,biological_process,positive regulation of peptidyl-threonine phosphorylation;GO:1901098,biological_process,positive regulation of autophagosome maturation;GO:0051434,molecular_function,BH3 domain binding;GO:0001934,biological_process,positive regulation of protein phosphorylation - 4930438A08Rik 0.748100631581403 0.810214646213014 0.935582036700006 0.175740961775811 0.0913037175245686 0.103461382473976 2.78181607092884 0.152929375024135 79.6118117804044 2.62492211099952e-06 7.97720231781804e-05 Q5SPH3,Amine oxidase XP_003689220.2,-;XP_001477520.3,L-amino-acid oxidase isoform X1 PF13450,NAD(P)-binding Rossmann-like domain;PF00890,AD binding domain;PF00070,Pyridine nucleotide-disulphide oxidoreductase;PF01593,lavin containing amine oxidoreductase IPR002937,Amine oxidase;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR001613,Flavin amine oxidase COG1231,Monoamine oxidase;ENOG410JJXJ,- GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0003674,molecular_function,molecular_function K03334,ko00950,Isoquinoline alkaloid biosynthesis;K03334,ko00270,Cysteine and methionine metabolism;K03334,ko00380,Tryptophan metabolism;K03334,ko00250,Alanine, aspartate and glutamate metabolism;K03334,ko00360,Phenylalanine metabolism;K03334,ko00280,Valine, leucine and isoleucine degradation;K03334,ko00350,Tyrosine metabolism;K03334,ko00400,Phenylalanine, tyrosine and tryptophan biosynthesis Xaf1 9.71054084129844 9.60277282674205 8.31739879633777 2.73248024085894 2.53697864757686 2.67852229986049 1.81811508846863 4.80684227945397 643.4818407912 5.79616121681975e-11 3.05546867837429e-08 D3ZPQ3,XIAP associated factor-1 - - IPR031220,XIAP-associated factor 1 ENOG410IK96,-;ENOG4110HW5,- GO:0005515,molecular_function,protein binding;GO:0006915,biological_process,apoptotic process;GO:0031333,biological_process,negative regulation of protein complex assembly;GO:0034097,biological_process,response to cytokine;GO:0035456,biological_process,response to interferon-beta;GO:0005634,cellular_component,nucleus - Gm6733 0.554545178589539 0.674035065531679 0.679921250976775 0.127717303123879 0.273709047990644 0.4511347364959 1.15893457063179 5.85789365829894e-05 10.9032404933771 0.00723344885188367 0.0377607654995076 Q6IAX9,SRPR protein - PF04086,Signal recognition particle, alpha subunit, N-terminal;PF00448,SRP54-type protein, GTPase domain;PF02881,SRP54-type protein, helical bundle domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007222,Signal recognition particle receptor, alpha subunit, N-terminal;IPR011012,Longin-like domain superfamily;IPR036225,SRP/SRP receptor, N-terminal;IPR003593,AAA+ ATPase domain;IPR000897,Signal recognition particle, SRP54 subunit, GTPase domain;IPR013822,Signal recognition particle, SRP54 subunit, helical bundle KOG0781,Signal recognition particle receptor, alpha subunit;COG0552,Signal recognition particle GTPase GO:0006614,biological_process,SRP-dependent cotranslational protein targeting to membrane;GO:0005047,molecular_function,signal recognition particle binding;GO:0005785,cellular_component,signal recognition particle receptor complex;GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0006886,biological_process,intracellular protein transport - Cpd 23.7008515739333 21.6380353117856 20.3943733850355 9.6532943849369 10.4184560422258 9.73957229967384 1.15783021719887 7.05548879977396 439.953961378058 4.33809069688864e-10 1.23870564774074e-07 F1LPC6,Carboxypeptidase D - PF00246,Zinc carboxypeptidase;PF13620,Carboxypeptidase regulatory-like domain IPR000834,Peptidase M14, carboxypeptidase A;IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR034224,Carboxypeptidase D, carboxypeptidase-like domain 2;IPR015567,Peptidase M14B, caboxypeptidase D;IPR034241,Carboxypeptidase D, carboxypeptidase-like domain 1 ENOG410XX0H,-;KOG2649,Zinc carboxypeptidase GO:0006508,biological_process,proteolysis;GO:0004185,molecular_function,serine-type carboxypeptidase activity;GO:0004181,molecular_function,metallocarboxypeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding - Nos2 2.71135949939144 2.17464653649512 2.50270197549021 0.583585863775478 0.77964103672271 0.49080841685864 1.98845194461613 2.79110518802567 163.555041601325 7.40174218873908e-08 5.48369072642475e-06 M0RDG2,Nitric oxide synthase - PF02898,Nitric oxide synthase, oxygenase domain;PF00175,Oxidoreductase NAD-binding domain;PF00258,lavodoxin;PF00667,AD binding domain IPR001709,Flavoprotein pyridine nucleotide cytochrome reductase;IPR017938,Riboflavin synthase-like beta-barrel;IPR017927,Ferredoxin reductase-type FAD-binding domain;IPR012144,Nitric-oxide synthase, eukaryote;IPR004030,Nitric oxide synthase, N-terminal;IPR008254,Flavodoxin/nitric oxide synthase;IPR003097,FAD-binding, type 1;IPR023173,NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily;IPR029039,Flavoprotein-like superfamily;IPR001433,Oxidoreductase FAD/NAD(P)-binding;IPR036119,Nitric oxide synthase, N-terminal domain superfamily;IPR001094,Flavodoxin-like KOG1158,NADP/FAD dependent oxidoreductase;COG4362,Nitric oxide synthase, oxygenase domain;COG0369,Sulfite reductase, alpha subunit (flavoprotein) GO:0030863,cellular_component,cortical cytoskeleton;GO:0005102,molecular_function,signaling receptor binding;GO:1900015,biological_process,regulation of cytokine production involved in inflammatory response;GO:0001666,biological_process,response to hypoxia;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0005506,molecular_function,iron ion binding;GO:0018119,biological_process,peptidyl-cysteine S-nitrosylation;GO:0034617,molecular_function,tetrahydrobiopterin binding;GO:0010181,molecular_function,FMN binding;GO:0032310,biological_process,prostaglandin secretion;GO:0006809,biological_process,nitric oxide biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0005516,molecular_function,calmodulin binding;GO:0050661,molecular_function,NADP binding;GO:0050796,biological_process,regulation of insulin secretion;GO:0004517,molecular_function,nitric-oxide synthase activity;GO:0010629,biological_process,negative regulation of gene expression;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0042742,biological_process,defense response to bacterium;GO:0042127,biological_process,regulation of cell proliferation;GO:0035690,biological_process,cellular response to drug;GO:0072604,biological_process,interleukin-6 secretion;GO:0005777,cellular_component,peroxisome;GO:0006527,biological_process,arginine catabolic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0006801,biological_process,superoxide metabolic process;GO:0020037,molecular_function,heme binding;GO:0032496,biological_process,response to lipopolysaccharide;GO:0072606,biological_process,interleukin-8 secretion;GO:0042177,biological_process,negative regulation of protein catabolic process;GO:0051712,biological_process,positive regulation of killing of cells of other organism;GO:0034618,molecular_function,arginine binding;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0007623,biological_process,circadian rhythm;GO:0005622,cellular_component,intracellular;GO:0055114,biological_process,oxidation-reduction process;GO:0042803,molecular_function,protein homodimerization activity - Lgals9 17.1451222051741 16.7059503438055 14.6865535540889 7.28652016699269 7.42217618373913 6.20653310855379 1.23262559158574 4.63715056744038 249.08793157901 8.52030898641695e-09 1.07268534587324e-06 G3X9T7,Galectin NP_034838.2,galectin-9 isoform 1 PF00337,alactoside-binding lectin IPR001079,Galectin, carbohydrate recognition domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily ENOG4111EA0,-;KOG3587,Galectin, galactose-binding lectin GO:0030246,molecular_function,carbohydrate binding - Tmem98 0.92047987570354 0.628531969801274 0.666181262438971 0.225245458050687 0.380324992364664 0.33151358468774 1.19827178909312 -0.0550101944585152 16.4540115174433 0.00197155433821197 0.0140886985190476 G3GTS8,Transmembrane protein 98 XP_003495835.1,- PF13324,rap2 and cyclin-D-interacting IPR029668,Transmembrane protein 98 - GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Ccl2 2.25647660801037 2.50970937678119 2.1030956093482 0.107740431457754 0.251887540569757 0.380570603722376 3.18049231422347 0.644430830377372 113.769059023428 4.58969584375002e-07 2.08299242498139e-05 Q5SVU3,C-C motif chemokine NP_035463.1,C-C motif chemokine 2 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR000827,CC chemokine, conserved site;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain ENOG410YXJU,-;ENOG410J1ST,- GO:0014823,biological_process,response to activity;GO:0032967,biological_process,positive regulation of collagen biosynthetic process;GO:0009408,biological_process,response to heat;GO:0071392,biological_process,cellular response to estradiol stimulus;GO:0001666,biological_process,response to hypoxia;GO:0045471,biological_process,response to ethanol;GO:0009612,biological_process,response to mechanical stimulus;GO:0005576,cellular_component,extracellular region;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0071398,biological_process,cellular response to fatty acid;GO:0002523,biological_process,leukocyte migration involved in inflammatory response;GO:0070098,biological_process,chemokine-mediated signaling pathway;GO:0001938,biological_process,positive regulation of endothelial cell proliferation;GO:0034612,biological_process,response to tumor necrosis factor;GO:0048247,biological_process,lymphocyte chemotaxis;GO:0043679,cellular_component,axon terminus;GO:0071403,biological_process,cellular response to high density lipoprotein particle stimulus;GO:1905237,biological_process,response to cyclosporin A;GO:0071300,biological_process,cellular response to retinoic acid;GO:0050806,biological_process,positive regulation of synaptic transmission;GO:0001912,biological_process,positive regulation of leukocyte mediated cytotoxicity;GO:0071402,biological_process,cellular response to lipoprotein particle stimulus;GO:0002693,biological_process,positive regulation of cellular extravasation;GO:0071354,biological_process,cellular response to interleukin-6;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0031727,molecular_function,CCR2 chemokine receptor binding;GO:2000427,biological_process,positive regulation of apoptotic cell clearance;GO:0009611,biological_process,response to wounding;GO:0071318,biological_process,cellular response to ATP;GO:0046677,biological_process,response to antibiotic;GO:0010332,biological_process,response to gamma radiation;GO:0006935,biological_process,chemotaxis;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0033552,biological_process,response to vitamin B3;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0010574,biological_process,regulation of vascular endothelial growth factor production;GO:0005615,cellular_component,extracellular space;GO:0030425,cellular_component,dendrite;GO:0071347,biological_process,cellular response to interleukin-1;GO:0005791,cellular_component,rough endoplasmic reticulum;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0042493,biological_process,response to drug;GO:0050870,biological_process,positive regulation of T cell activation;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0048246,biological_process,macrophage chemotaxis;GO:0008009,molecular_function,chemokine activity;GO:0036120,biological_process,cellular response to platelet-derived growth factor stimulus;GO:0071333,biological_process,cellular response to glucose stimulus;GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0005125,molecular_function,cytokine activity;GO:0043025,cellular_component,neuronal cell body;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0007568,biological_process,aging;GO:0008347,biological_process,glial cell migration;GO:0051770,biological_process,positive regulation of nitric-oxide synthase biosynthetic process;GO:0010759,biological_process,positive regulation of macrophage chemotaxis;GO:0032760,biological_process,positive regulation of tumor necrosis factor production;GO:0043200,biological_process,response to amino acid;GO:0090314,biological_process,positive regulation of protein targeting to membrane;GO:0090303,biological_process,positive regulation of wound healing;GO:0043204,cellular_component,perikaryon;GO:0006954,biological_process,inflammatory response;GO:0071549,biological_process,cellular response to dexamethasone stimulus;GO:0035684,biological_process,helper T cell extravasation;GO:0032496,biological_process,response to lipopolysaccharide;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0002544,biological_process,chronic inflammatory response;GO:0045785,biological_process,positive regulation of cell adhesion;GO:0090026,biological_process,positive regulation of monocyte chemotaxis;GO:0060137,biological_process,maternal process involved in parturition;GO:0048010,biological_process,vascular endothelial growth factor receptor signaling pathway;GO:0031100,biological_process,animal organ regeneration;GO:0030139,cellular_component,endocytic vesicle;GO:0022409,biological_process,positive regulation of cell-cell adhesion;GO:0045202,cellular_component,synapse;GO:0036006,biological_process,cellular response to macrophage colony-stimulating factor stimulus;GO:0035690,biological_process,cellular response to drug;GO:0060135,biological_process,maternal process involved in female pregnancy;GO:0005737,cellular_component,cytoplasm;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0051384,biological_process,response to glucocorticoid;GO:0006955,biological_process,immune response;GO:0030593,biological_process,neutrophil chemotaxis;GO:0008201,molecular_function,heparin binding;GO:0090265,biological_process,positive regulation of immune complex clearance by monocytes and macrophages;GO:0044299,cellular_component,C-fiber;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0032570,biological_process,response to progesterone;GO:0002687,biological_process,positive regulation of leukocyte migration K14624,ko04062,Chemokine signaling pathway;K14624,ko05144,Malaria;K14624,ko04933,AGE-RAGE signaling pathway in diabetic complications;K14624,ko05168,Herpes simplex infection;K14624,ko04668,TNF signaling pathway;K14624,ko05323,Rheumatoid arthritis;K14624,ko04621,NOD-like receptor signaling pathway;K14624,ko05164,Influenza A;K14624,ko05142,Chagas disease (American trypanosomiasis);K14624,ko04060,Cytokine-cytokine receptor interaction Slfn5os 6.3085656272554 5.87181182314348 5.5775754163612 1.44638107349003 1.95087128744362 2.01414056584376 1.71428309531804 2.12962803254428 140.631289210687 1.58981447262307e-07 9.23304964481855e-06 Q9DAQ2,MCG1050995 - - - - - - Slfn5 15.870608402817 16.8175522188496 18.2544775949882 4.83573323494018 4.67475827545656 5.60530987805528 1.77490480804157 6.13174044465884 382.536898075891 1.44969505555654e-09 2.87964064224028e-07 A0A1G5SK44,Schlafen family member 5 - - IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR029684,Schlafen family;IPR018647,Domain of unknown function DUF2075;IPR007421,Schlafen, AAA domain;IPR029671,Schlafen family member 5;IPR038461,Schlafen, AAA domain superfamily - GO:0005524,molecular_function,ATP binding;GO:0005634,cellular_component,nucleus - Slfn8 19.4430092379647 18.5986158895852 19.864137843252 9.5455494018962 9.52924245389883 9.09106518619457 1.05979971879165 5.8814483507293 359.380061405494 1.25761642864575e-09 2.53483687809098e-07 A0A1G5SJB6,Schlafen family member 8 - - IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR029679,Schlafen family member 13;IPR018647,Domain of unknown function DUF2075;IPR007421,Schlafen, AAA domain;IPR029684,Schlafen family;IPR038461,Schlafen, AAA domain superfamily - GO:0005524,molecular_function,ATP binding - Gm11425 26.0333611833955 28.4959735224361 28.6167659045647 13.9104147016852 13.4306301752254 13.4796885121666 1.05107635103395 3.38264206162258 126.231040114308 2.73452117128528e-07 1.44707904145313e-05 Q5BLK0,MCG18564, isoform CRA_a NP_033102.2,60S ribosomal protein L12 PF00298,Ribosomal protein L11, RNA binding domain;PF03946,Ribosomal protein L11, N-terminal domain IPR020784,Ribosomal protein L11, N-terminal;IPR036769,Ribosomal protein L11, C-terminal domain superfamily;IPR020783,Ribosomal protein L11, C-terminal;IPR020785,Ribosomal protein L11, conserved site;IPR000911,Ribosomal protein L11/L12;IPR036796,Ribosomal protein L11/L12, N-terminal domain superfamily KOG0886,40S ribosomal protein S2;COG0080,Ribosomal protein L11 GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0003735,molecular_function,structural constituent of ribosome;GO:0005634,cellular_component,nucleus;GO:0005840,cellular_component,ribosome;GO:0006412,biological_process,translation;GO:0030529,, K02870,ko03010,Ribosome Slfn2 210.363326004769 225.891141524138 246.732961652534 68.8568190976531 71.2026334633003 77.1375331897917 1.67441065272237 7.97175191991415 402.782509106717 7.49459239940671e-10 1.65678844235917e-07 Q9Z0I6,Schlafen 2 NP_035538.1,schlafen family member 12-like PF04326,Putative DNA-binding domain IPR029684,Schlafen family;IPR007421,Schlafen, AAA domain;IPR038461,Schlafen, AAA domain superfamily ENOG410JAUV,-;ENOG4111BZ2,- GO:0008285,biological_process,negative regulation of cell proliferation;GO:0005524,molecular_function,ATP binding - RP23-392I13.15 1.92173175351728 2.36510356279475 2.27588703255824 1.11151460459276 0.866207409388419 0.37751860794636 1.51661289740154 0.237085703648381 23.8359189720325 0.000513595973370118 0.00478905682830908 A0A1X6RH82,Uncharacterized protein - - - - - - Slfn1 1.24321160966299 1.60403786499177 1.63414549590985 0.0657771518234572 0.205041502981676 0.232344070298317 3.11712153506981 0.744506486309606 99.495660427814 8.89382151844563e-07 3.43376669667087e-05 Q9Z0I7,Schlafen 1 NP_035537.1,schlafen 1 PF04326,Putative DNA-binding domain IPR029684,Schlafen family;IPR007421,Schlafen, AAA domain;IPR038461,Schlafen, AAA domain superfamily - GO:0005515,molecular_function,protein binding;GO:0005737,cellular_component,cytoplasm;GO:0008285,biological_process,negative regulation of cell proliferation;GO:2000134,biological_process,negative regulation of G1/S transition of mitotic cell cycle;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005524,molecular_function,ATP binding;GO:0007050,biological_process,cell cycle arrest;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:1900477,biological_process,negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter;GO:0005634,cellular_component,nucleus - Slfn4 126.747164650664 131.119157798072 141.994452171699 52.7520146464847 49.6306992588043 51.0223827108582 1.40413032667542 8.52019121569571 411.083141228673 6.20367461185872e-10 1.46599248672648e-07 Q3UV66,Schlafen 4 XP_006532723.1,-;XP_006532726.1,-;NP_035540.2,schlafen 4;NP_001289488.1,-;XP_006532722.1,-;XP_006532724.1,- PF04326,Putative DNA-binding domain IPR029684,Schlafen family;IPR007421,Schlafen, AAA domain;IPR038461,Schlafen, AAA domain superfamily ENOG410JAUV,-;ENOG4111BZ2,- GO:0008150,biological_process,biological_process;GO:0005575,cellular_component,cellular_component;GO:0005524,molecular_function,ATP binding;GO:0003674,molecular_function,molecular_function - Ccl5 1.43529340340822 1.06915906946404 1.24652229345742 0.447010560933578 0.597183377434131 0.338351052371925 1.40841085607587 -0.109636293630253 22.584023732332 0.000630749650376576 0.00563311932425265 Q5XZF2,C-C motif chemokine NP_038681.2,C-C motif chemokine 5 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR030595,C-C motif chemokine 5;IPR000827,CC chemokine, conserved site;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain ENOG410ZUYI,-;ENOG410J0XH,- GO:0070234,biological_process,positive regulation of T cell apoptotic process;GO:0050863,biological_process,regulation of T cell activation;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0010759,biological_process,positive regulation of macrophage chemotaxis;GO:0006887,biological_process,exocytosis;GO:0016004,molecular_function,phospholipase activator activity;GO:0043621,molecular_function,protein self-association;GO:2000110,biological_process,negative regulation of macrophage apoptotic process;GO:0033634,biological_process,positive regulation of cell-cell adhesion mediated by integrin;GO:0045071,biological_process,negative regulation of viral genome replication;GO:1901214,biological_process,regulation of neuron death;GO:0042379,molecular_function,chemokine receptor binding;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:0004672,molecular_function,protein kinase activity;GO:0006935,biological_process,chemotaxis;GO:0042327,biological_process,positive regulation of phosphorylation;GO:0030298,molecular_function,receptor signaling protein tyrosine kinase activator activity;GO:0034112,biological_process,positive regulation of homotypic cell-cell adhesion;GO:0031328,biological_process,positive regulation of cellular biosynthetic process;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:2000503,biological_process,positive regulation of natural killer cell chemotaxis;GO:0048245,biological_process,eosinophil chemotaxis;GO:0007267,biological_process,cell-cell signaling;GO:0031663,biological_process,lipopolysaccharide-mediated signaling pathway;GO:0071347,biological_process,cellular response to interleukin-1;GO:0070233,biological_process,negative regulation of T cell apoptotic process;GO:0031730,molecular_function,CCR5 chemokine receptor binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0050796,biological_process,regulation of insulin secretion;GO:0006955,biological_process,immune response;GO:0045744,biological_process,negative regulation of G-protein coupled receptor protein signaling pathway;GO:0046817,molecular_function,chemokine receptor antagonist activity;GO:0070098,biological_process,chemokine-mediated signaling pathway;GO:0006954,biological_process,inflammatory response;GO:0050918,biological_process,positive chemotaxis;GO:0009636,biological_process,response to toxic substance;GO:0042119,biological_process,neutrophil activation;GO:0010820,biological_process,positive regulation of T cell chemotaxis;GO:0042056,molecular_function,chemoattractant activity;GO:0061098,biological_process,positive regulation of protein tyrosine kinase activity;GO:0031584,biological_process,activation of phospholipase D activity;GO:0034612,biological_process,response to tumor necrosis factor;GO:0042531,biological_process,positive regulation of tyrosine phosphorylation of STAT protein;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0031726,molecular_function,CCR1 chemokine receptor binding;GO:0000165,biological_process,MAPK cascade;GO:0031729,molecular_function,CCR4 chemokine receptor binding;GO:0045785,biological_process,positive regulation of cell adhesion;GO:0043491,biological_process,protein kinase B signaling;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0090026,biological_process,positive regulation of monocyte chemotaxis;GO:0008009,molecular_function,chemokine activity;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0070100,biological_process,negative regulation of chemokine-mediated signaling pathway;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:2000406,biological_process,positive regulation of T cell migration;GO:0051262,biological_process,protein tetramerization;GO:0004435,molecular_function,phosphatidylinositol phospholipase C activity;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0007159,biological_process,leukocyte cell-cell adhesion;GO:0042802,molecular_function,identical protein binding;GO:0005125,molecular_function,cytokine activity;GO:0034097,biological_process,response to cytokine;GO:0006816,biological_process,calcium ion transport;GO:0009615,biological_process,response to virus;GO:0005737,cellular_component,cytoplasm;GO:0043922,biological_process,negative regulation by host of viral transcription;GO:0030335,biological_process,positive regulation of cell migration;GO:0014911,biological_process,positive regulation of smooth muscle cell migration;GO:0051928,biological_process,positive regulation of calcium ion transport K12499,ko05168,Herpes simplex infection;K12499,ko04623,Cytosolic DNA-sensing pathway;K12499,ko04060,Cytokine-cytokine receptor interaction;K12499,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K12499,ko05323,Rheumatoid arthritis;K12499,ko04620,Toll-like receptor signaling pathway;K12499,ko05020,Prion diseases;K12499,ko04668,TNF signaling pathway;K12499,ko04621,NOD-like receptor signaling pathway;K12499,ko05164,Influenza A;K12499,ko05142,Chagas disease (American trypanosomiasis);K12499,ko04062,Chemokine signaling pathway Ccl3 494.75207504523 450.918353374141 465.754933175631 101.080075516737 104.904693560753 105.516056645699 2.19840871994824 7.78788718404571 1553.51390320441 5.24459661378767e-13 2.39608137295246e-09 Q5QNW0,C-C motif chemokine NP_035467.1,C-C motif chemokine 3 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR000827,CC chemokine, conserved site;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain ENOG410J4I9,-;ENOG410YXJU,- GO:0032760,biological_process,positive regulation of tumor necrosis factor production;GO:0006935,biological_process,chemotaxis;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0050718,biological_process,positive regulation of interleukin-1 beta secretion;GO:0043525,biological_process,positive regulation of neuron apoptotic process;GO:0006955,biological_process,immune response;GO:0030593,biological_process,neutrophil chemotaxis;GO:0045672,biological_process,positive regulation of osteoclast differentiation;GO:0006954,biological_process,inflammatory response;GO:0042493,biological_process,response to drug;GO:0007204,biological_process,positive regulation of cytosolic calcium ion concentration;GO:0048246,biological_process,macrophage chemotaxis;GO:0005623,cellular_component,cell;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008009,molecular_function,chemokine activity;GO:0008360,biological_process,regulation of cell shape;GO:0030595,biological_process,leukocyte chemotaxis;GO:0050729,biological_process,positive regulation of inflammatory response;GO:0005125,molecular_function,cytokine activity;GO:0043615,biological_process,astrocyte cell migration K05408,ko05142,Chagas disease (American trypanosomiasis);K05408,ko05323,Rheumatoid arthritis;K05408,ko04620,Toll-like receptor signaling pathway;K05408,ko04062,Chemokine signaling pathway;K05408,ko04060,Cytokine-cytokine receptor interaction;K05408,ko05132,Salmonella infection Ccl4 203.835387141875 180.058219888237 142.330181871138 43.4703257178004 47.6298984668677 41.6684447527122 1.99952290838984 6.1838727632442 367.786117116613 4.23235354655684e-09 6.25770802981634e-07 Q5QNV9,C-C motif chemokine XP_011247134.1,-;NP_038680.1,C-C motif chemokine 4 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR000827,CC chemokine, conserved site;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain ENOG410J4I9,-;ENOG410YXJU,- GO:0035690,biological_process,cellular response to drug;GO:0005125,molecular_function,cytokine activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0006955,biological_process,immune response;GO:0008009,molecular_function,chemokine activity;GO:0005576,cellular_component,extracellular region;GO:0006935,biological_process,chemotaxis;GO:0060326,biological_process,cell chemotaxis;GO:0005615,cellular_component,extracellular space K12964,ko04062,Chemokine signaling pathway;K12964,ko04623,Cytosolic DNA-sensing pathway;K12964,ko04060,Cytokine-cytokine receptor interaction;K12964,ko05132,Salmonella infection;K12964,ko04064,NF-kappa B signaling pathway;K12964,ko04620,Toll-like receptor signaling pathway Wfdc17 15.6283695844415 12.5588470513763 10.5113529231682 2.99045392680303 3.04753993737493 3.04706388627625 2.09401500542018 2.12168941375073 154.680273697766 9.82536679207191e-08 6.53720763359891e-06 Q5SSJ1,Activated macrophage/microglia WAP domain protein NP_001075426.1,activated macrophage/microglia WAP domain protein precursor PF00095,WAP-type (Whey Acidic Protein) 'four-disulfide core' IPR036645,Elafin-like superfamily;IPR008197,WAP-type 'four-disulfide core' domain ENOG4111T0F,-;KOG4802,Adhesion-type protein GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0030414,molecular_function,peptidase inhibitor activity;GO:0008150,biological_process,biological_process;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0010466,biological_process,negative regulation of peptidase activity;GO:0005575,cellular_component,cellular_component;GO:0005576,cellular_component,extracellular region - Srcin1 1.55299680012668 1.96095661639192 2.13978146363061 0.8209825385992 0.844728945690464 0.747643254456482 1.2556765125319 3.70334802137325 90.2505923907136 1.43205986853315e-06 4.91712437297118e-05 B1AQX9,SRC kinase-signaling inhibitor 1 NP_061361.2,SRC kinase signaling inhibitor 1 PF03915,Actin interacting protein 3 IPR026727,SRC kinase signalling inhibitor 1;IPR022782,Actin interacting protein 3-like, C-terminal ENOG410IHFG,-;ENOG410XTBA,- GO:0019904,molecular_function,protein domain specific binding;GO:0030334,biological_process,regulation of cell migration;GO:0019901,molecular_function,protein kinase binding;GO:0030175,cellular_component,filopodium;GO:0030425,cellular_component,dendrite;GO:0005737,cellular_component,cytoplasm;GO:0015629,cellular_component,actin cytoskeleton;GO:0030424,cellular_component,axon;GO:0043025,cellular_component,neuronal cell body;GO:0061099,biological_process,negative regulation of protein tyrosine kinase activity;GO:0030027,cellular_component,lamellipodium;GO:0050709,biological_process,negative regulation of protein secretion;GO:0014069,cellular_component,postsynaptic density;GO:0061098,biological_process,positive regulation of protein tyrosine kinase activity;GO:0061001,biological_process,regulation of dendritic spine morphogenesis;GO:0045202,cellular_component,synapse;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0043005,cellular_component,neuron projection - Gm11611 0.944660405369458 0.807706241735574 1.35368936846055 0.462325079181464 0.396320793470615 0.28578671090238 1.44575802783202 0.0650055805107846 20.2874480138603 0.000939904291042762 0.00776979988723287 A0A1U8C3W5,uncharacterized protein LOC106021593 XP_012973110.1,- - - - - - Csf3 14.0509711292926 11.6222811797365 11.3945755294622 0.0867718407635699 0.473351297046162 0.229877572736764 5.45857791800733 3.17932889004277 551.67669832737 1.31149022964804e-10 5.28684855516356e-08 Q0VB73,Colony stimulating factor 3 NP_034101.1,granulocyte colony-stimulating factor precursor PF16647,ranulocyte colony-stimulating factor IPR009079,Four-helical cytokine-like, core;IPR030473,Interleukin-6/GCSF/MGF, conserved site;IPR030474,Interleukin-6/GCSF/MGF ENOG4111DA4,-;ENOG410IIM2,- GO:0019899,molecular_function,enzyme binding;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:0005130,molecular_function,granulocyte colony-stimulating factor receptor binding;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0005125,molecular_function,cytokine activity;GO:0042993,biological_process,obsolete positive regulation of transcription factor import into nucleus;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006955,biological_process,immune response;GO:2000251,biological_process,positive regulation of actin cytoskeleton reorganization;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0045639,biological_process,positive regulation of myeloid cell differentiation;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0071345,biological_process,cellular response to cytokine stimulus;GO:0032092,biological_process,positive regulation of protein binding;GO:0005576,cellular_component,extracellular region K05423,ko05144,Malaria;K05423,ko04060,Cytokine-cytokine receptor interaction;K05423,ko04630,Jak-STAT signaling pathway;K05423,ko04151,PI3K-Akt signaling pathway;K05423,ko04640,Hematopoietic cell lineage Dhx58os 1.88600205398228 2.26768341174851 1.87682152088947 0.769188274773678 0.809232180211872 0.611324360621796 1.48480777517209 1.20367454591601 63.7433242266511 7.52472444559359e-06 0.000178741548095851 Q3U606,Uncharacterized protein - PF00271,Helicase conserved C-terminal domain;PF11648,C-terminal domain of RIG-I;PF04851,Type III restriction enzyme, res subunit IPR006935,Helicase/UvrB, N-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR038557,RIG-I-like receptor, C-terminal domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR021673,RIG-I-like receptor, C-terminal regulatory domain;IPR001650,Helicase, C-terminal KOG0354,DEAD-box like helicase;COG1111,ERCC4-like helicases GO:0046872,molecular_function,metal ion binding;GO:0016787,molecular_function,hydrolase activity;GO:0003677,molecular_function,DNA binding;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding - Dhx58 8.72852356462523 8.56509274740196 7.94626792095106 2.86661330727925 2.7011962059979 2.76306238367293 1.61972750506682 4.2069177098388 514.637971905852 1.89481589381514e-10 6.18341586681672e-08 Q3U606,Uncharacterized protein - PF00271,Helicase conserved C-terminal domain;PF11648,C-terminal domain of RIG-I;PF04851,Type III restriction enzyme, res subunit IPR006935,Helicase/UvrB, N-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR038557,RIG-I-like receptor, C-terminal domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR021673,RIG-I-like receptor, C-terminal regulatory domain;IPR001650,Helicase, C-terminal KOG0354,DEAD-box like helicase;COG1111,ERCC4-like helicases GO:0046872,molecular_function,metal ion binding;GO:0016787,molecular_function,hydrolase activity;GO:0003677,molecular_function,DNA binding;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding - Gm11626 26.5194260285745 21.7098339839467 20.254711140209 10.861723797202 12.1947356352916 10.0794067253138 1.05105609835105 2.52279224412904 65.9754768861202 6.4045736816425e-06 0.000159023708117015 A0A1A6GMK1,Uncharacterized protein - PF07292,Nmi/IFP 35 domain (NID);PF07334,Interferon-induced 35 kDa protein (IFP 35) N-terminus IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR009938,Nmi/IFP 35 domain, N-terminal;IPR034460,Interferon-induced 35kDa protein;IPR009909,Nmi/IFP 35 domain - - - Cd300ld2 1.5009604218648 1.40974654228848 1.65906710477993 0.868143759796304 0.520421243951313 0.76663419273813 1.11836205343408 0.181947729826331 18.0056106017641 0.00144252993729123 0.0109354620135584 A2A7W0,CD300 molecule-like family member D2 - PF07686,Immunoglobulin V-set domain IPR013106,Immunoglobulin V-set domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold ENOG410J31V,-;ENOG410ZH9V,- GO:0016020,cellular_component,membrane;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0003674,molecular_function,molecular_function - Cd300ld5 6.54243856099009 5.9710537131121 4.72433545279637 2.73422958800418 2.52331004549633 2.47806404554086 1.17302559917114 1.86929815062992 59.3030201329681 1.05268192941649e-05 0.000232710621364233 A2A7W1,CD300 molecule-like family member D4 NP_001095127.1,-;NP_001095126.1,CD300 molecule like family member D4 precursor PF07686,Immunoglobulin V-set domain IPR013106,Immunoglobulin V-set domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold ENOG410J31V,-;ENOG410ZH9V,- GO:0003674,molecular_function,molecular_function;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Cd300ld3 15.6577462189988 16.0275652299325 14.8114300682265 7.19534102106363 7.34563591022265 6.4175504769135 1.16920786714138 3.27920240189368 165.920966027766 6.88021418169993e-08 5.23890086524329e-06 A2A7W1,CD300 molecule-like family member D4 NP_001095127.1,-;NP_001095126.1,CD300 molecule like family member D4 precursor PF07686,Immunoglobulin V-set domain IPR013106,Immunoglobulin V-set domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold ENOG410J31V,-;ENOG410ZH9V,- GO:0003674,molecular_function,molecular_function;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Socs3 20.0393154653391 19.4803602760753 21.97573216578 4.96202265197998 4.97411820429398 4.51290784485002 2.10999999855529 5.20512190882741 717.201190380434 3.25656797644072e-11 2.18462475777463e-08 F1PZ18,Suppressor of cytokine-signaling 3 - PF07525,SOCS box;PF00017,SH2 domain IPR028414,Suppressor of cytokine signalling 3;IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR035863,SOCS3, SH2 domain ENOG4111V4J,-;KOG4566,Cytokine-inducible SH2 protein GO:0009968,biological_process,negative regulation of signal transduction;GO:0042532,biological_process,negative regulation of tyrosine phosphorylation of STAT protein;GO:0007259,biological_process,JAK-STAT cascade;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0016567,biological_process,protein ubiquitination;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0060674,biological_process,placenta blood vessel development;GO:0045595,biological_process,regulation of cell differentiation;GO:0005622,cellular_component,intracellular;GO:0060670,biological_process,branching involved in labyrinthine layer morphogenesis;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0060708,biological_process,spongiotrophoblast differentiation;GO:0046627,biological_process,negative regulation of insulin receptor signaling pathway;GO:0035556,biological_process,intracellular signal transduction;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0060707,biological_process,trophoblast giant cell differentiation;GO:0045597,biological_process,positive regulation of cell differentiation - Rsad2 1.24451587322911 1.20638056218558 1.36989679032289 0.226633292049768 0.176616155987913 0.0875584978411635 2.98354129408411 1.69267723426797 174.385155210888 5.33919617763855e-08 4.27947501817041e-06 A0A0H2UHF4,RCG62278 - PF04055,Radical SAM superfamily;PF13353,4Fe-4S single cluster domain IPR007197,Radical SAM;IPR026372,Antiviral radical SAM protein viperin;IPR034395,SPASM/twitch domain-containing;IPR006638,Elp3/MiaB/NifB;IPR013785,Aldolase-type TIM barrel - GO:0051607,biological_process,defense response to virus;GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0050709,biological_process,negative regulation of protein secretion;GO:0043621,molecular_function,protein self-association;GO:0034165,biological_process,positive regulation of toll-like receptor 9 signaling pathway;GO:0003824,molecular_function,catalytic activity;GO:2000553,biological_process,positive regulation of T-helper 2 cell cytokine production;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0035710,biological_process,CD4-positive, alpha-beta T cell activation;GO:0001650,cellular_component,fibrillar center;GO:0009615,biological_process,response to virus;GO:0045071,biological_process,negative regulation of viral genome replication;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0034157,biological_process,positive regulation of toll-like receptor 7 signaling pathway;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005811,cellular_component,lipid droplet;GO:0043367,biological_process,CD4-positive, alpha-beta T cell differentiation;GO:0005783,cellular_component,endoplasmic reticulum - Cmpk2 1.15548095925069 1.08843341111928 0.850433084398718 0.0958478822693279 0.134450291354776 0.135425061612278 3.05949706459991 0.969374226594908 164.351209149323 7.22117061107064e-08 5.41076710952759e-06 D3ZC63,Cytidine/uridine monophosphate kinase 2 XP_006240001.1,-;XP_006240000.1,UMP-CMP kinase 2, mitochondrial isoform X1 PF02223,Thymidylate kinase IPR014505,UMP-CMP kinase, mitochondrai;IPR027417,P-loop containing nucleoside triphosphate hydrolase COG0125,Thymidylate kinase;KOG3327,Thymidylate kinase/adenylate kinase GO:0006227,biological_process,dUDP biosynthetic process;GO:0006235,biological_process,dTTP biosynthetic process;GO:0004798,molecular_function,thymidylate kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0006165,biological_process,nucleoside diphosphate phosphorylation;GO:0006233,biological_process,dTDP biosynthetic process;GO:0009041,molecular_function,uridylate kinase activity;GO:0004127,molecular_function,cytidylate kinase activity;GO:0004550,molecular_function,nucleoside diphosphate kinase activity;GO:0009142,biological_process,nucleoside triphosphate biosynthetic process;GO:0005739,cellular_component,mitochondrion;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0033862,molecular_function,UMP kinase activity - Nfkbia 104.84831964022 93.5528187340354 90.0927993684888 47.3485377922288 48.8955724123621 41.9495229928717 1.07967700725653 6.81269435825777 294.017652758708 3.595673700954e-09 5.73050043549715e-07 A0A1U7QWG7,NF-kappa-B inhibitor alpha XP_005080564.1,NF-kappa-B inhibitor alpha - IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily - - - Flrt2 16.5966837270154 15.9580042186392 15.5199224546233 7.26504850822534 7.13433424874036 7.51638032674945 1.15222597126204 6.49807302697381 538.73272327069 1.48723833672359e-10 5.66224684531486e-08 G3GUD7,Leucine-rich repeat transmembrane protein FLRT2 XP_007643913.1,-;XP_007643910.1,leucine-rich repeat transmembrane protein FLRT2;XP_007630309.1,-;XP_007630310.1,- PF01463,Leucine rich repeat C-terminal domain;PF00041,ibronectin type III domain;PF13855,Leucine rich repeat IPR001611,Leucine-rich repeat;IPR003961,Fibronectin type III;IPR000483,Cysteine-rich flanking region, C-terminal;IPR036116,Fibronectin type III superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold - GO:0005104,molecular_function,fibroblast growth factor receptor binding;GO:0003007,biological_process,heart morphogenesis;GO:0061343,biological_process,cell adhesion involved in heart morphogenesis;GO:0007411,biological_process,axon guidance;GO:0050919,biological_process,negative chemotaxis;GO:0005911,cellular_component,cell-cell junction;GO:0005887,cellular_component,integral component of plasma membrane;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0071711,biological_process,basement membrane organization;GO:0016020,cellular_component,membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0045499,molecular_function,chemorepellent activity;GO:0005925,cellular_component,focal adhesion;GO:2001222,biological_process,regulation of neuron migration;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space - Crip1 2.00529030524019 2.15299766848594 1.69383890594214 4.32894437956728 4.6936518086051 4.511347364959 -1.1852063509857 2.89821334039069 120.350986736233 3.4698675150036e-07 1.72311609277679e-05 A0A0G2JEK2,Cysteine-rich protein 1 - PF00412,LIM domain IPR001781,Zinc finger, LIM-type - GO:0046872,molecular_function,metal ion binding - Ighj4 8.11883137281417 8.26403145479453 6.04374445312689 20.4347684998207 23.8873350973653 13.0327812765482 -1.32464701009078 -0.27857850865741 15.8328014097956 0.00224628595182532 0.0154789317524976 - - - - - - - Aoah 1.43954579303316 1.71460933923147 1.53011437612612 0.820194824864159 0.803073358333377 0.594290699191854 1.10762036972927 1.79625543341412 48.0604544639919 2.74232242025718e-05 0.000499153666561022 Q4FK10,Aoah protein - PF00657,SL-like Lipase/Acylhydrolase IPR008139,Saposin B type domain;IPR001087,GDSL lipase/esterase;IPR011001,Saposin-like ENOG410XTCS,-;ENOG410IFCC,- GO:0016788,molecular_function,hydrolase activity, acting on ester bonds - Hist1h2be 0.343654238002716 0.275467715159818 0.174099634452215 0.490546568925737 0.578888321975473 0.680724568100809 -1.13720110090851 0.967638836219483 22.9175734727802 0.000596682615681153 0.00539099006626624 A0A0G2JXI9,Histone H2B - PF00125,Core histone H2A/H2B/H3/H4 IPR000558,Histone H2B;IPR009072,Histone-fold;IPR007125,Histone H2A/H2B/H3 - GO:0000786,cellular_component,nucleosome;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0005634,cellular_component,nucleus;GO:0046982,molecular_function,protein heterodimerization activity;GO:0006334,biological_process,nucleosome assembly - Gm11398 1.76149644963736 0.697277653998288 1.01988187646516 2.49048741091565 3.28450857588772 3.21433499753329 -1.41613045673449 -0.382765686288827 15.9307208896042 0.0022000922893184 0.0152630370105466 G3N0M9,Histone H2B - PF00125,Core histone H2A/H2B/H3/H4 IPR000558,Histone H2B;IPR009072,Histone-fold;IPR007125,Histone H2A/H2B/H3 KOG1744,Histone H2B;ENOG4111NV5,- GO:0000786,cellular_component,nucleosome;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0006334,biological_process,nucleosome assembly;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus - Cd83 3.71168225816676 3.3734833022185 3.32504652834186 1.11566398249138 1.3153082321461 1.38940236158327 1.45239173586631 2.37919919881936 135.106824495067 1.94503605947281e-07 1.10159769550142e-05 B2GV95,CD83 antigen NP_001101880.1,CD83 antigen precursor PF07686,Immunoglobulin V-set domain IPR003599,Immunoglobulin subtype;IPR013783,Immunoglobulin-like fold;IPR036179,Immunoglobulin-like domain superfamily;IPR013106,Immunoglobulin V-set domain;IPR007110,Immunoglobulin-like domain ENOG410ZACF,-;ENOG410IKX7,- GO:0043372,biological_process,positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0032743,biological_process,positive regulation of interleukin-2 production;GO:0006959,biological_process,humoral immune response;GO:0032733,biological_process,positive regulation of interleukin-10 production;GO:0009897,cellular_component,external side of plasma membrane;GO:0032713,biological_process,negative regulation of interleukin-4 production;GO:0014070,biological_process,response to organic cyclic compound;GO:0006952,biological_process,defense response;GO:0001817,biological_process,regulation of cytokine production;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane - Ctla2b 2.07495852248283 1.71188655070548 1.47010000211195 0.534475200518414 1.08294806021185 0.80236692454371 1.08784324103123 0.657641539866788 18.2611902039247 0.00137253653910185 0.0105094892764972 A0A0R4J245,Protein CTLA-2-beta NP_001139273.1,protein CTLA-2-beta isoform b PF08246,Cathepsin propeptide inhibitor domain (I29) IPR013201,Cathepsin propeptide inhibitor domain (I29);IPR013128,Peptidase C1A - GO:0006508,biological_process,proteolysis;GO:0008234,molecular_function,cysteine-type peptidase activity - Ell2 27.3055294633485 28.4126782575754 27.890380901049 11.9179469698708 12.405432595122 13.12212033109 1.1785248267981 6.2077961329305 398.935414292723 7.26482604446453e-10 1.63232304533493e-07 B9EKX8,Ell2 protein - PF07303,Occludin homology domain;PF10390,RNA polymerase II elongation factor ELL IPR019464,RNA polymerase II elongation factor ELL, N-terminal;IPR010844,Occludin homology domain;IPR031176,ELL/occludin family;IPR031179,RNA polymerase II elongation factor ELL2;IPR036390,Winged helix DNA-binding domain superfamily ENOG410ZNGU,-;KOG4796,RNA polymerase II elongation factor GO:0006368,biological_process,transcription elongation from RNA polymerase II promoter;GO:0008023,cellular_component,transcription elongation factor complex - Glrx 44.7031564914165 41.8719119391329 39.7943500943433 19.7814636332837 20.7793175196412 18.9577214176567 1.10311351894077 5.38720689410003 386.163097421637 8.621058034922e-10 1.85188527666585e-07 Q3U6L3,Glutaredoxin, isoform CRA_a NP_444338.2,glutaredoxin-1;XP_006517540.1,- PF00462,lutaredoxin IPR011899,Glutaredoxin, eukaryotic/virial;IPR011767,Glutaredoxin active site;IPR002109,Glutaredoxin;IPR036249,Thioredoxin-like superfamily;IPR014025,Glutaredoxin subgroup COG0695,Glutaredoxin and related proteins;KOG1752,Glutaredoxin and related proteins GO:0045838,biological_process,positive regulation of membrane potential;GO:0022900,biological_process,electron transport chain;GO:0005737,cellular_component,cytoplasm;GO:0045454,biological_process,cell redox homeostasis;GO:0047485,molecular_function,protein N-terminus binding;GO:0009055,molecular_function,electron transfer activity;GO:2000651,biological_process,positive regulation of sodium ion transmembrane transporter activity;GO:0015035,molecular_function,protein disulfide oxidoreductase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0005634,cellular_component,nucleus;GO:0005739,cellular_component,mitochondrion - Gm807 0.836049130672017 0.906501419011123 0.820798724336443 0.676019619552977 0.221820871478726 0.408456290733374 1.04867529194761 0.28070586735965 10.5997079407169 0.00784671535906605 0.0400697022024439 Q3ULA9,Uncharacterized protein - - - - GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Plk2 26.3085900067973 22.9340144869673 24.2655692711197 6.2573273993027 5.95052101997179 6.02801018358547 2.02961903783018 5.42993413570651 979.867999877118 6.17218307245154e-12 9.39954902122454e-09 Q548A9,Serine/threonine-protein kinase PLK NP_690017.2,serine/threonine-protein kinase PLK2 PF00069,Protein kinase domain;PF00659,POLO box duplicated region IPR036947,POLO box domain superfamily;IPR033701,First polo-box domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000959,POLO box domain;IPR033695,Second polo-box domain;IPR000719,Protein kinase domain KOG0575,Polo-like serine/threonine protein kinase;ENOG410XQBP,- GO:0061000,biological_process,negative regulation of dendritic spine development;GO:0000785,cellular_component,chromatin;GO:0007265,biological_process,Ras protein signal transduction;GO:0090050,biological_process,positive regulation of cell migration involved in sprouting angiogenesis;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:0043008,molecular_function,ATP-dependent protein binding;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048167,biological_process,regulation of synaptic plasticity;GO:0032486,biological_process,Rap protein signal transduction;GO:0060292,biological_process,long term synaptic depression;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0000278,biological_process,mitotic cell cycle;GO:0005813,cellular_component,centrosome;GO:0046599,biological_process,regulation of centriole replication;GO:0007093,biological_process,mitotic cell cycle checkpoint;GO:0010508,biological_process,positive regulation of autophagy;GO:0016310,biological_process,phosphorylation;GO:2000773,biological_process,negative regulation of cellular senescence;GO:0030425,cellular_component,dendrite;GO:0000166,molecular_function,nucleotide binding;GO:0007052,biological_process,mitotic spindle organization;GO:0016740,molecular_function,transferase activity;GO:0005814,cellular_component,centriole;GO:0006468,biological_process,protein phosphorylation;GO:0032092,biological_process,positive regulation of protein binding;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0060291,biological_process,long-term synaptic potentiation;GO:0071866,biological_process,negative regulation of apoptotic process in bone marrow;GO:0007613,biological_process,memory;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005622,cellular_component,intracellular K08861,ko04068,FoxO signaling pathway Gm15326 1.00597060776435 0.982244785644228 1.29431766991415 0.364689503268662 0.824191216922775 0.354252142876019 1.05464862695375 0.55468558757818 11.4225802051157 0.00631157926820953 0.0341922946443003 - - - - - - - Gm21738 0.183938281574141 5.50450024654155 7.9873274710928 0.540126039642838 0.631383306538289 1.58990215505163 2.37346573004026 1.02188506669431 6.32951125109927 0.0386838303772776 0.13345093862345 J3QP72,Predicted gene, 21738 - - - ENOG410YF7P,-;ENOG410J9TA,- GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Phf11a 1.52645679535291 1.81271590995124 1.52655879096706 0.452764442388937 0.564545585757524 0.559753587380437 1.63679148170972 0.652560485384142 57.2875368050566 1.23482233909002e-05 0.000261988776773496 B4XVQ1,PHD finger protein 11B NP_001157799.1,PHD finger protein 11 family member PF13771,PHD-like zinc-binding domain IPR034732,Extended PHD (ePHD) domain;IPR013083,Zinc finger, RING/FYVE/PHD-type KOG1084,Transcription factor TCF20;COG2940,Proteins containing SET domain GO:0031965,cellular_component,nuclear membrane;GO:0005654,cellular_component,nucleoplasm;GO:0003674,molecular_function,molecular_function;GO:0046872,molecular_function,metal ion binding;GO:0008150,biological_process,biological_process - Phf11b 12.0077986206511 11.1941331479725 10.7041656403776 5.28128307512258 4.43852510255098 6.08117431965757 1.12372821275863 3.31244415405624 93.3367168491321 1.21577061194423e-06 4.28363804815107e-05 B4XVQ1,PHD finger protein 11B NP_001157799.1,PHD finger protein 11 family member PF13771,PHD-like zinc-binding domain IPR034732,Extended PHD (ePHD) domain;IPR013083,Zinc finger, RING/FYVE/PHD-type KOG1084,Transcription factor TCF20;COG2940,Proteins containing SET domain GO:0031965,cellular_component,nuclear membrane;GO:0005654,cellular_component,nucleoplasm;GO:0003674,molecular_function,molecular_function;GO:0046872,molecular_function,metal ion binding;GO:0008150,biological_process,biological_process - Phf11d 18.5330904557469 19.5250144678507 19.7355532520071 8.36835117311466 7.76418050519075 8.74988759713257 1.23815356485631 5.96122689457779 340.774171298489 1.66198902048902e-09 3.2541745021175e-07 B4XVP9,PHD finger protein 11C NP_001157761.1,PHD finger protein 11 family member PF13771,PHD-like zinc-binding domain IPR034732,Extended PHD (ePHD) domain;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type KOG1084,Transcription factor TCF20;COG2940,Proteins containing SET domain GO:0031965,cellular_component,nuclear membrane;GO:0008150,biological_process,biological_process;GO:0003674,molecular_function,molecular_function;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm - Acod1 18.6722951479329 17.7448257566503 21.0067930534342 1.28545055374396 2.20386393197194 1.54792704096954 3.50482193257905 4.78697581615785 554.051408007238 5.29194645503726e-10 1.36516580359842e-07 A0A0R4J027,Cis-aconitate decarboxylase NP_032418.1,cis-aconitate decarboxylase PF03972,MmgE/PrpD family IPR036148,MmgE/PrpD superfamily;IPR005656,MmgE/PrpD - GO:0047613,molecular_function,aconitate decarboxylase activity;GO:0006952,biological_process,defense response;GO:0002760,biological_process,positive regulation of antimicrobial humoral response;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0016829,molecular_function,lyase activity;GO:0072573,biological_process,tolerance induction to lipopolysaccharide K17724,ko00660,C5-Branched dibasic acid metabolism Fyb 182.772334190765 187.314646784231 211.690715132499 87.0743375065634 89.736417733681 95.50555428155 1.11686539200619 9.53372769509958 184.187152213381 4.03735610093024e-08 3.57006469157096e-06 B2RUR0,FYN binding protein NP_035945.1,FYN-binding protein 1 isoform 1 PF14603,Helically-extended SH3 domain;PF07653,Variant SH3 domain IPR001452,SH3 domain;IPR029294,Helically-extended SH3 domain;IPR036028,SH3-like domain superfamily;IPR035540,FYB, helically extended SH3 domain;IPR030635,FYN-binding protein ENOG410IEQF,-;ENOG410YD3U,- GO:0006955,biological_process,immune response;GO:0015629,cellular_component,actin cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:0008289,molecular_function,lipid binding;GO:0072659,biological_process,protein localization to plasma membrane K17698,ko04015,Rap1 signaling pathway Gm2245 29.1078244284467 29.8342306175192 30.4997850260435 13.4557139736675 13.3446427706253 13.5981844744736 1.16758732964269 6.19760117048712 449.763180180497 3.86169219838205e-10 1.12613517597924e-07 Q7R7I1,Uncharacterized protein - - - - - - Gdnf 0.321276069469339 0.34337297979739 0.217016757222567 0 0.0544595841490231 0.030855610361646 3.2123197148268 -0.556975004472216 38.8545851842971 6.98457433781752e-05 0.00101841038163965 G3T9X6,Glial cell derived neurotrophic factor - PF00019,Transforming growth factor beta like domain IPR001839,Transforming growth factor-beta, C-terminal;IPR029034,Cystine-knot cytokine ENOG410IGT5,-;ENOG4111I3D,- GO:0048255,biological_process,mRNA stabilization;GO:0008083,molecular_function,growth factor activity;GO:0072107,biological_process,positive regulation of ureteric bud formation;GO:0032770,biological_process,positive regulation of monooxygenase activity;GO:0007422,biological_process,peripheral nervous system development;GO:0051584,biological_process,regulation of dopamine uptake involved in synaptic transmission;GO:0048485,biological_process,sympathetic nervous system development;GO:0072108,biological_process,positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0005576,cellular_component,extracellular region;GO:0001759,biological_process,organ induction;GO:0042803,molecular_function,protein homodimerization activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0003337,biological_process,mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0001657,biological_process,ureteric bud development;GO:0048484,biological_process,enteric nervous system development;GO:0001941,biological_process,postsynaptic membrane organization;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0045597,biological_process,positive regulation of cell differentiation;GO:0060676,biological_process,ureteric bud formation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0021784,biological_process,postganglionic parasympathetic fiber development;GO:0007399,biological_process,nervous system development;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0001755,biological_process,neural crest cell migration;GO:0010468,biological_process,regulation of gene expression;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0060688,biological_process,regulation of morphogenesis of a branching structure;GO:0001656,biological_process,metanephros development;GO:0030432,biological_process,peristalsis;GO:0090190,biological_process,positive regulation of branching involved in ureteric bud morphogenesis;GO:0031175,biological_process,neuron projection development - 4930556M19Rik 0.106039838946582 0.206060196348578 0.217675265819869 0.0471789329686487 0.0955934604481294 0.0749923834716903 1.29081012993258 -0.100348542760184 12.3991457429503 0.00493009665863252 0.0282609388553816 - - - - - - - Basp1 151.9488052135 152.674737260082 145.216748828001 60.2089930568621 61.4578323674498 59.6171989625984 1.33058373750216 7.60680021572494 787.438587427964 1.98054698842768e-11 1.69658606396186e-08 - - - - - - - Myo10 21.068810857811 23.1417374010639 23.472800033721 10.7685294584117 11.3418822839298 10.9481067647553 1.05529157646632 7.414557318847 264.321347127645 6.26030411103863e-09 8.41213021038191e-07 A0A1U7QLA6,unconventional myosin-X XP_005081356.1,unconventional myosin-X - IPR019748,FERM central domain;IPR038185,MyTH4 domain superfamily;IPR001609,Myosin head, motor domain;IPR031971,Unconventional myosin-X, coiled coil domain;IPR000159,Ras-associating (RA) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000299,FERM domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR036124,Class X myosin, motor domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily;IPR000857,MyTH4 domain - GO:0003777,molecular_function,microtubule motor activity;GO:0003774,molecular_function,motor activity;GO:0005856,cellular_component,cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0016459,cellular_component,myosin complex;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0007165,biological_process,signal transduction - Col14a1 0.348297220898874 0.311801329379528 0.364537844527688 0.0874152367024984 0.197556742570538 0.115791034606106 1.31957398097968 0.83299724974831 25.8983959956413 0.000372145433571131 0.00373946137281959 K3W4R4,Collagen alpha-1 - PF00092,von Willebrand factor type A domain;PF00041,ibronectin type III domain;PF01391,Collagen triple helix repeat (20 copies) IPR008160,Collagen triple helix repeat;IPR003961,Fibronectin type III;IPR036465,von Willebrand factor A-like domain superfamily;IPR036116,Fibronectin type III superfamily;IPR001791,Laminin G domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013783,Immunoglobulin-like fold;IPR002035,von Willebrand factor, type A ENOG410Y01G,-;KOG3544,Collagens (type IV and type XIII), and related proteins - - Myc 1.89022479198807 1.37967047033301 1.32130445533948 0.315885269412024 0.193419717387573 0.278949708249213 2.55939933414386 1.34341562016065 123.387914043061 3.06423681329494e-07 1.56127991684091e-05 F8WID3,Myc proto-oncogene protein - PF00010,Helix-loop-helix DNA-binding domain;PF02344,Myc leucine zipper domain;PF01056,Myc amino-terminal region IPR003327,Leucine zipper, Myc;IPR012682,Transcription regulator Myc, N-terminal;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR002418,Transcription regulator Myc;IPR036638,Helix-loop-helix DNA-binding domain superfamily ENOG410IFSM,-;ENOG41124Q3,- GO:0001541,biological_process,ovarian follicle development;GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0046983,molecular_function,protein dimerization activity;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0046982,molecular_function,protein heterodimerization activity;GO:1904628,biological_process,cellular response to phorbol 13-acetate 12-myristate;GO:0060252,biological_process,positive regulation of glial cell proliferation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0010918,biological_process,positive regulation of mitochondrial membrane potential;GO:0002082,biological_process,regulation of oxidative phosphorylation;GO:0006865,biological_process,amino acid transport;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0071409,biological_process,cellular response to cycloheximide;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0008134,molecular_function,transcription factor binding;GO:0045471,biological_process,response to ethanol;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0044330,biological_process,canonical Wnt signaling pathway involved in positive regulation of wound healing;GO:0006848,biological_process,pyruvate transport;GO:1901857,biological_process,positive regulation of cellular respiration;GO:0005634,cellular_component,nucleus;GO:0030728,biological_process,ovulation;GO:0071378,biological_process,cellular response to growth hormone stimulus;GO:0071966,biological_process,fungal-type cell wall polysaccharide metabolic process;GO:0071347,biological_process,cellular response to interleukin-1;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0060548,biological_process,negative regulation of cell death;GO:0009611,biological_process,response to wounding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0046325,biological_process,negative regulation of glucose import;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0005739,cellular_component,mitochondrion;GO:0045821,biological_process,positive regulation of glycolytic process;GO:0045787,biological_process,positive regulation of cell cycle;GO:1903862,biological_process,positive regulation of oxidative phosphorylation;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0021854,biological_process,hypothalamus development;GO:0046722,biological_process,lactic acid secretion;GO:0071391,biological_process,cellular response to estrogen stimulus;GO:0006006,biological_process,glucose metabolic process;GO:0003677,molecular_function,DNA binding;GO:0071300,biological_process,cellular response to retinoic acid;GO:0035690,biological_process,cellular response to drug;GO:0043565,molecular_function,sequence-specific DNA binding;GO:1904586,biological_process,cellular response to putrescine;GO:1903841,biological_process,cellular response to arsenite(3-);GO:2001171,biological_process,positive regulation of ATP biosynthetic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0045023,biological_process,G0 to G1 transition;GO:0008284,biological_process,positive regulation of cell proliferation;GO:1990646,biological_process,cellular response to prolactin;GO:0010629,biological_process,negative regulation of gene expression;GO:1904620,biological_process,cellular response to dimethyl sulfoxide;GO:0000320,biological_process,re-entry into mitotic cell cycle;GO:0036120,biological_process,cellular response to platelet-derived growth factor stimulus;GO:1990859,biological_process,cellular response to endothelin;GO:0005654,cellular_component,nucleoplasm;GO:0007346,biological_process,regulation of mitotic cell cycle;GO:0097421,biological_process,liver regeneration;GO:1904385,biological_process,cellular response to angiotensin;GO:0071322,biological_process,cellular response to carbohydrate stimulus;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0005730,cellular_component,nucleolus;GO:0032355,biological_process,response to estradiol;GO:1990858,biological_process,cellular response to lectin;GO:0044752,biological_process,response to human chorionic gonadotropin;GO:0003690,molecular_function,double-stranded DNA binding;GO:0001701,biological_process,in utero embryonic development;GO:0019087,biological_process,transformation of host cell by virus;GO:0071394,biological_process,cellular response to testosterone stimulus;GO:0008283,biological_process,cell proliferation;GO:0007007,biological_process,inner mitochondrial membrane organization;GO:0043388,biological_process,positive regulation of DNA binding;GO:0009812,biological_process,flavonoid metabolic process;GO:0014911,biological_process,positive regulation of smooth muscle cell migration;GO:0071464,biological_process,cellular response to hydrostatic pressure;GO:0006351,biological_process,transcription, DNA-templated - Apol9a 3.54364758675369 3.65971030604569 3.14674297972722 0.506647152888117 0.880779043640931 0.688317461913642 2.30508725269805 1.75779295406105 162.680668496376 7.60625382880768e-08 5.57493662982022e-06 Q8VDU3,Apol9a protein XP_006520862.1,-;NP_001156355.1,-;NP_776147.1,apolipoprotein L 9a PF05461,Apolipoprotein L IPR008405,Apolipoprotein L - GO:0008150,biological_process,biological_process;GO:0008289,molecular_function,lipid binding;GO:0006869,biological_process,lipid transport;GO:0005576,cellular_component,extracellular region;GO:0005575,cellular_component,cellular_component;GO:0042157,biological_process,lipoprotein metabolic process;GO:0003674,molecular_function,molecular_function - Apol9b 2.79711194591823 3.0328193105945 2.78129599105063 0.714224918440335 0.52567598272519 0.490554276578066 2.34857629326192 1.47667296361026 171.102226891799 5.88270215846439e-08 4.65439684478014e-06 Q8C7I4,Apolipoprotein L 9b XP_006521481.1,-;NP_776104.1,apolipoprotein L 9b;NP_001162131.1,- PF05461,Apolipoprotein L IPR008405,Apolipoprotein L - GO:0008150,biological_process,biological_process;GO:0008289,molecular_function,lipid binding;GO:0042157,biological_process,lipoprotein metabolic process;GO:0006869,biological_process,lipid transport;GO:0005575,cellular_component,cellular_component;GO:0005576,cellular_component,extracellular region;GO:0003674,molecular_function,molecular_function - Maff 8.2759206065496 8.19227204999593 9.65173724841028 3.90565419652071 3.62988291710789 4.13877266516295 1.18440848745828 3.75562253716281 121.267662270684 3.3410626494553e-07 1.66518562448852e-05 Q3UKW6,Uncharacterized protein - PF03131,bZIP Maf transcription factor IPR033531,Transcription factor MafF;IPR024874,Transcription factor Maf family;IPR008917,Transcription factor, Skn-1-like, DNA-binding domain superfamily;IPR004826,Basic leucine zipper domain, Maf-type;IPR004827,Basic-leucine zipper domain ENOG41102C7,-;KOG4196,bZIP transcription factor MafK GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus - Rapgef3 0.0790795263585796 0.063388877636208 0.0772637785200881 0.17415995880529 0.158344077349959 0.119619058919367 -1.02189934953493 -0.301397805540743 11.8551043790586 0.00564925584685415 0.0313476520797502 Q3UQC2,Uncharacterized protein NP_001171281.1,rap guanine nucleotide exchange factor 3 isoform 1 PF00618,RasGEF N-terminal motif;PF00610,omain found in Dishevelled, Egl-10, and Pleckstrin (DEP);PF00027,Cyclic nucleotide-binding domain;PF00617,RasGEF domain IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR014710,RmlC-like jelly roll fold;IPR019804,Ras guanine-nucleotide exchange factor, conserved site;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR000595,Cyclic nucleotide-binding domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR018490,Cyclic nucleotide-binding-like;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily;IPR000591,DEP domain KOG2378,cAMP-regulated guanine nucleotide exchange factor;ENOG410XPX9,- GO:0065009,biological_process,regulation of molecular function;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component,intracellular;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0035556,biological_process,intracellular signal transduction - 4930562C15Rik 0.0824556881948402 0.0587512486348003 0.17391252611029 0.24212721750775 0.251587505257185 0.173089122146255 -1.08135471858222 -0.0389670658418093 8.35350370342219 0.014973142904502 0.0649779318874889 A0A075B686,RIKEN cDNA 4930562C15 gene - - - ENOG410IJ37,-;ENOG4112C1S,- - - Cebpd 26.333102290361 24.7073803206398 23.9587840707246 10.0646417197462 10.4961435051423 10.4052432550042 1.29358570875654 6.05367131774517 657.591726525481 5.16536204317088e-11 2.831858086548e-08 B9EIA9,CCAAT/enhancer binding protein NP_031705.3,CCAAT/enhancer-binding protein delta PF07716,Basic region leucine zipper IPR016468,CCAAT/enhancer-binding protein, chordates;IPR004827,Basic-leucine zipper domain - GO:0006366,biological_process,transcription by RNA polymerase II;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus - Igf2bp2 14.061450958697 13.6173994119223 13.2799651992771 6.43046143789057 6.42489254196418 6.55919919785372 1.09600785975437 6.17046302955015 523.729159808437 1.7271187326983e-10 6.03705637766197e-08 D3ZWZ6,Insulin-like growth factor 2 mRNA-binding protein 2 NP_001257527.1,insulin-like growth factor 2 mRNA-binding protein 2 isoform 1 PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF00013,KH domain IPR004088,K Homology domain, type 1;IPR004087,K Homology domain;IPR028743,Insulin-like growth factor 2 mRNA-binding protein 2;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034843,IGF2BP2, RNA recognition motif 1;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR036612,K Homology domain, type 1 superfamily KOG2193,IGF-II mRNA-binding protein IMP, contains RRM and KH domains;ENOG410ZKB4,- GO:0003730,molecular_function,mRNA 3'-UTR binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0005856,cellular_component,cytoskeleton;GO:0048027,molecular_function,mRNA 5'-UTR binding;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding - St6gal1 0.0764413973262755 0.154320196816545 0.110646257278564 0.473873801663865 0.369291592229406 0.418465093250875 -1.79145313145882 0.501411228763396 45.6495184538992 3.44998043517088e-05 0.000594038088498142 G3V680,Beta-galactoside alpha-2,6-sialyltransferase 1 NP_001106815.1,beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1;XP_006248563.1,- PF00777,lycosyltransferase family 29 (sialyltransferase) IPR012163,Sialyltransferase;IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29 ENOG410XT8P,-;KOG2692,Sialyltransferase GO:0005794,cellular_component,Golgi apparatus;GO:0097503,biological_process,sialylation;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0003835,molecular_function,beta-galactoside alpha-2,6-sialyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0018279,biological_process,protein N-linked glycosylation via asparagine;GO:0016020,cellular_component,membrane;GO:0008373,molecular_function,sialyltransferase activity;GO:0006054,biological_process,N-acetylneuraminate metabolic process;GO:0016021,cellular_component,integral component of membrane K00778,ko00514,Other types of O-glycan biosynthesis;K00778,ko00510,N-Glycan biosynthesis Rtp4 12.6672709908746 12.1459157749491 11.6649089327597 3.19323224328498 3.13864562518173 3.6327883990003 1.89013404567802 4.05837099517248 505.818369161005 2.07626015407969e-10 6.61795852832934e-08 Q8R3Q4,Rtp4 protein - PF13695,Zinc-binding domain IPR026096,Receptor-transporting protein;IPR027377,Zinc-binding domain;IPR026690,Receptor-transporting protein 4 ENOG4111X4F,-;ENOG410IH22,- GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - A230028O05Rik 8.7006165885736 7.07812962626547 7.47840344790781 3.57773068256796 3.8144473517454 3.12063125997164 1.15640020625078 3.98610071123712 140.801399362321 1.58015956059193e-07 9.23304964481855e-06 - - - - - - - Parp14 22.0682354833857 22.6965150148216 22.754639415883 8.68905855940152 8.73250741470413 9.19721493745993 1.3630449070017 7.19599336343156 590.227744958381 9.1677700100145e-11 4.06004635404838e-08 B2RSI3,Poly [ADP-ribose] polymerase - PF01661,Macro domain;PF00644,Poly(ADP-ribose) polymerase catalytic domain IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR002589,Macro domain;IPR034517,PARP-14, RNA recognition motif 2;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR012317,Poly(ADP-ribose) polymerase, catalytic domain COG2110,Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1;KOG2633,Hismacro and SEC14 domain-containing proteins GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:0016740,molecular_function,transferase activity - Gm5483 7.41284603604772 7.76100345319834 7.35760194293708 1.03654622825178 1.03857978684197 1.30763691737942 2.74167754407041 0.930493812550236 168.181892683483 6.42206654621995e-08 4.94499124058936e-06 B2RV77,MCG130182, isoform CRA_a NP_001076016.1,EG433016 protein PF00031,Cystatin domain IPR001713,Proteinase inhibitor I25A, stefin;IPR000010,Cystatin domain;IPR018073,Proteinase inhibitor I25, cystatin, conserved site ENOG410J1PC,-;ENOG41121QW,- GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0004869,molecular_function,cysteine-type endopeptidase inhibitor activity;GO:0005622,cellular_component,intracellular - Nfkbiz 21.9545441205411 20.9433415724635 21.3000439724091 3.39629273193513 3.86538782364699 3.21494184477748 2.63072677502114 5.97415879136689 1569.63587970076 4.96230397323708e-13 2.39608137295246e-09 M5AJR0,Molecule possessing ankyrin-repeats induced by lipopolysaccharide - PF12796,Ankyrin repeats (3 copies);PF13637,Ankyrin repeats (many copies) IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat - - Mir155hg 4.67656342060814 3.95497053154088 3.87170789111688 1.28341183878846 1.06684539164786 1.13334616286479 1.86067120312992 1.97418817124651 162.041695075063 7.75995031047322e-08 5.62740100292836e-06 - - - - - - - Mir155 24.0888403369212 17.1637576368809 15.0628707908701 6.6020021307113 3.67497463036389 3.33145651566203 2.0576107727482 -0.220982699210256 34.5959850818575 0.000114522505437416 0.00148079760332568 - - - - - - - 1600002D24Rik 1.2724127852911 0.926765423643775 0.687595305728206 0.525860859814799 0.301961798070531 0.513254869512265 1.12730544601141 0.728713489448091 16.1158337159308 0.00211581502228483 0.0148867354699363 - - - - - - - Mx1 1.49448592545572 2.09298042933551 1.98419147295471 0.252211898653849 0.170343036898381 0.237569581478916 3.12292345916106 1.97534096292076 203.238513037996 2.43663186819867e-08 2.36854442450574e-06 E9Q0J3,Interferon-induced GTP-binding protein Mx1 - PF00350,ynamin family;PF01031,ynamin central region;PF02212,ynamin GTPase effector domain IPR019762,Dynamin, GTPase region, conserved site;IPR000375,Dynamin central domain;IPR020850,GTPase effector domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR001401,Dynamin, GTPase domain;IPR022812,Dynamin superfamily;IPR003130,Dynamin GTPase effector KOG0446,Vacuolar sorting protein VPS1, dynamin, and related proteins;COG0699,Predicted GTPases (dynamin-related) GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding - Mx2 6.55077816356561 6.08757734890813 6.36650114362315 0.661557253591318 0.660966660137389 1.06354951714031 3.00895004772663 3.70714309497726 438.047346561757 4.43860136519873e-10 1.24154021043702e-07 Q61924,Interferon-induced Mx2 - PF00350,ynamin family;PF01031,ynamin central region IPR019762,Dynamin, GTPase region, conserved site;IPR000375,Dynamin central domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR001401,Dynamin, GTPase domain;IPR022812,Dynamin superfamily KOG0446,Vacuolar sorting protein VPS1, dynamin, and related proteins;COG0699,Predicted GTPases (dynamin-related) GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding - Lix1 1.8603262834454 2.09223906429772 2.3601226883061 0.142817252182789 0.222596017214819 0.189177058984885 3.49724726048376 2.02580499162759 297.005956402503 3.41086127457269e-09 5.70112983284064e-07 A0A158RFU7,Limb expression 1 homolog NP_079957.2,protein limb expression 1 homolog PF14954,Limb expression 1 IPR029270,Limb expression 1 - - - Zfp811 2.3726602136366 1.92285705856786 2.84709650495769 0.390021608151581 0.46973359936982 0.454004882303566 2.44048961412314 2.32341086451105 152.060858520567 1.07134064383378e-07 6.99228326875516e-06 A0A0J9YU71,Zinc finger protein 811 NP_899000.2,zinc finger protein 811 isoform 1 PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily - GO:0008150,biological_process,biological_process;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005575,cellular_component,cellular_component;GO:0003674,molecular_function,molecular_function - H2-Eb1 1.42824036457083 1.80915283199556 2.06732812796992 3.67618723856572 4.39817487434597 3.97791102112939 -1.15527807832621 1.82080885658278 48.2699999415537 2.68937296098758e-05 0.000491473944043943 A0A0N8DT83,DLA class II histocompatibility antigen, DR-1 beta chain - PF07654,Immunoglobulin C1-set domain;PF00969,Class II histocompatibility antigen, beta domain IPR000353,MHC class II, beta chain, N-terminal;IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014745,MHC class II, alpha/beta chain, N-terminal;IPR003597,Immunoglobulin C1-set;IPR007110,Immunoglobulin-like domain;IPR011162,MHC classes I/II-like antigen recognition protein - GO:0006955,biological_process,immune response;GO:0042613,cellular_component,MHC class II protein complex;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0019882,biological_process,antigen processing and presentation - Tnf 140.738204574917 125.327894232254 125.51371183376 36.3561836153003 41.7991928366343 39.9662988036636 1.74530423300129 7.12696726187637 735.131664148065 2.85564263650255e-11 2.17441322088355e-08 A0A0U5J4W4,Tumor necrosis factor ligand 1f - PF00229,TNF(Tumour Necrosis Factor) family IPR006053,Tumour necrosis factor;IPR002959,Tumour necrosis factor alpha;IPR008983,Tumour necrosis factor-like domain superfamily;IPR021184,Tumour necrosis factor, conserved site;IPR006052,Tumour necrosis factor domain - GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005125,molecular_function,cytokine activity;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0006955,biological_process,immune response;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space - 4833427F10Rik 1.61354401714428 1.45222844276796 1.03255837436473 0.457184651182429 0.518233710586907 0.587239792591273 1.39235482576074 0.584702439929599 33.5865140483539 0.000129668694415018 0.00163499459581622 A0A0V1KI53,Uncharacterized protein - - - - - - Ier3 28.1867120264204 26.9490723356085 30.2507845704256 10.8407259945998 11.447334768145 10.3868687341762 1.40369589142509 4.48825374342786 303.233964971882 3.06064131404239e-09 5.24364373128312e-07 Q91VZ5,Gly96 protein NP_598423.1,radiation-inducible immediate-early gene IEX-1 - IPR024829,Radiation-inducible immediate-early gene IEX-1 ENOG410IZ8Q,-;ENOG410Z2E4,- GO:2001020,biological_process,regulation of response to DNA damage stimulus;GO:0005634,cellular_component,nucleus;GO:0043066,biological_process,negative regulation of apoptotic process - H2-T24 51.5514430968318 57.3876765424512 60.8750758894696 14.160114560829 12.9398854652089 14.9606368161518 2.03765856398813 6.27805364484288 524.787353219423 2.59887439959524e-10 7.91559389352273e-08 F8VQG4,Histocompatibility 2, T region locus 24 XP_011244608.1,-;NP_032233.2,histocompatibility 2, T region locus 24 precursor PF07654,Immunoglobulin C1-set domain;PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2 IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR001039,MHC class I alpha chain, alpha1 alpha2 domains;IPR037055,MHC class I-like antigen recognition-like superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR011161,MHC class I-like antigen recognition-like;IPR003597,Immunoglobulin C1-set;IPR007110,Immunoglobulin-like domain;IPR011162,MHC classes I/II-like antigen recognition protein ENOG410J90V,-;ENOG41117CA,- GO:0042605,molecular_function,peptide antigen binding;GO:0005102,molecular_function,signaling receptor binding;GO:0002474,biological_process,antigen processing and presentation of peptide antigen via MHC class I;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane K06751,ko04650,Natural killer cell mediated cytotoxicity;K06751,ko04145,Phagosome;K06751,ko05330,Allograft rejection;K06751,ko05168,Herpes simplex infection;K06751,ko05203,Viral carcinogenesis;K06751,ko05416,Viral myocarditis;K06751,ko04514,Cell adhesion molecules (CAMs);K06751,ko05332,Graft-versus-host disease;K06751,ko05166,HTLV-I infection;K06751,ko04144,Endocytosis;K06751,ko05320,Autoimmune thyroid disease;K06751,ko04612,Antigen processing and presentation;K06751,ko05169,Epstein-Barr virus infection;K06751,ko04940,Type I diabetes mellitus Gm26917 61.9160622489936 67.2402708312245 59.1647906226952 33.2394927685579 32.9356768089236 28.6536283222268 1.01053978799183 7.29923045361384 243.479485501399 9.58806808103081e-09 1.15275492209305e-06 A0A0V1F5M4,Uncharacterized protein - - - - - - F630040K05Rik 0.708848668268503 0.727640598072259 0.855607789450919 0.176398346919611 0.311593858933596 0.290775506354541 1.54825380443832 1.48124201938758 56.3400153955591 1.33324928321426e-05 0.000278984956881444 - - - - - - - Map3k8 3.58765410701748 3.35882237592071 3.35733761583558 1.64694071168626 1.75018218963822 1.71879930689823 1.0249978449819 3.54910163043475 156.699471711484 9.19998153743792e-08 6.27338044537931e-06 Q3UEB8,Mitogen-activated protein kinase kinase kinase 8 NP_031772.1,mitogen-activated protein kinase kinase kinase 8 PF00069,Protein kinase domain IPR017424,Mitogen-activated protein (MAP) kinase kinase kinase 8;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain KOG0201,Serine/threonine protein kinase;ENOG410XP9G,- GO:0005829,cellular_component,cytosol;GO:0016301,molecular_function,kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0000165,biological_process,MAPK cascade;GO:0005524,molecular_function,ATP binding;GO:0007049,biological_process,cell cycle;GO:0000287,molecular_function,magnesium ion binding;GO:0000186,biological_process,activation of MAPKK activity;GO:0004709,molecular_function,MAP kinase kinase kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0007165,biological_process,signal transduction;GO:0004672,molecular_function,protein kinase activity K04415,ko04660,T cell receptor signaling pathway;K04415,ko04010,MAPK signaling pathway;K04415,ko04620,Toll-like receptor signaling pathway;K04415,ko04668,TNF signaling pathway Gm3550 0.794233503862256 0.835385788365099 0.689775182150351 1.55481934237766 1.99061125811377 2.0268372219381 -1.24454430332255 1.19202551352031 44.1287954882254 4.00834166439376e-05 0.000663506411258223 W4VSN7,60S ribosomal protein L29 - PF01779,Ribosomal L29e protein family IPR002673,Ribosomal protein L29e KOG3504,60S ribosomal protein L29;ENOG4112428,- GO:0002181,biological_process,cytoplasmic translation;GO:0003735,molecular_function,structural constituent of ribosome;GO:0022625,cellular_component,cytosolic large ribosomal subunit;GO:0005840,cellular_component,ribosome;GO:0005622,cellular_component,intracellular;GO:0006412,biological_process,translation;GO:0030529,, - Egr1 12.9619879493585 11.6341491885673 12.1670118595844 4.44333168762828 4.65600599355424 4.57573769309401 1.44287473359721 5.24453199813521 560.008525787796 1.21135627885921e-10 5.03116641152858e-08 Q544D6,Early growth response protein NP_031939.1,early growth response protein 1 PF00096,Zinc finger, C2H2 type;PF11914,omain of unknown function (DUF3432);PF11928,omain of unknown function (DUF3446) IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR021849,Early growth response protein;IPR021839,Early growth response protein 1, C-terminal KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger GO:0061418,biological_process,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0050725,biological_process,positive regulation of interleukin-1 beta biosynthetic process;GO:0098759,biological_process,cellular response to interleukin-8;GO:1901216,biological_process,positive regulation of neuron death;GO:0003676,molecular_function,nucleic acid binding;GO:0070498,biological_process,interleukin-1-mediated signaling pathway;GO:0032868,biological_process,response to insulin;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0003677,molecular_function,DNA binding;GO:0009749,biological_process,response to glucose;GO:0005634,cellular_component,nucleus;GO:0044729,molecular_function,hemi-methylated DNA-binding;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0044849,biological_process,estrous cycle;GO:0071310,biological_process,cellular response to organic substance;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:1902949,biological_process,positive regulation of tau-protein kinase activity;GO:0033233,biological_process,regulation of protein sumoylation;GO:0008270,molecular_function,zinc ion binding;GO:0045080,biological_process,positive regulation of chemokine biosynthetic process;GO:2000182,biological_process,regulation of progesterone biosynthetic process;GO:0030509,biological_process,BMP signaling pathway;GO:0002931,biological_process,response to ischemia;GO:0030217,biological_process,T cell differentiation;GO:0010628,biological_process,positive regulation of gene expression;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0035035,molecular_function,histone acetyltransferase binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0046886,biological_process,positive regulation of hormone biosynthetic process;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0071480,biological_process,cellular response to gamma radiation;GO:0005654,cellular_component,nucleoplasm;GO:0042981,biological_process,regulation of apoptotic process;GO:0000982,molecular_function,transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0010385,molecular_function,double-stranded methylated DNA binding;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0001666,biological_process,response to hypoxia K09203,ko04933,AGE-RAGE signaling pathway in diabetic complications;K09203,ko05020,Prion diseases;K09203,ko05166,HTLV-I infection Hbegf 4.30208619249355 4.13723951466325 4.12594438013719 1.39504108595489 1.95286262490049 2.07601825644131 1.21610496794202 2.85695645600654 83.1539624614729 2.12898810257478e-06 6.69264012245182e-05 Q5FW64,Heparin-binding EGF-like growth factor NP_034545.1,proheparin-binding EGF-like growth factor precursor PF00008,-like domain IPR013032,EGF-like, conserved site;IPR015497,Epidermal growth factor receptor ligand;IPR000742,EGF-like domain ENOG410IMHM,-;ENOG41120D3,- GO:0008083,molecular_function,growth factor activity;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0051549,biological_process,positive regulation of keratinocyte migration;GO:0051545,biological_process,negative regulation of elastin biosynthetic process;GO:0035313,biological_process,wound healing, spreading of epidermal cells;GO:0005615,cellular_component,extracellular space;GO:0009986,cellular_component,cell surface;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:0090303,biological_process,positive regulation of wound healing;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0008201,molecular_function,heparin binding;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0030335,biological_process,positive regulation of cell migration;GO:0030307,biological_process,positive regulation of cell growth;GO:0060326,biological_process,cell chemotaxis;GO:0005154,molecular_function,epidermal growth factor receptor binding;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0016020,cellular_component,membrane;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0008016,biological_process,regulation of heart contraction;GO:0016477,biological_process,cell migration K08523,ko01522,Endocrine resistance;K08523,ko05219,Bladder cancer;K08523,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K08523,ko04012,ErbB signaling pathway;K08523,ko04915,Estrogen signaling pathway;K08523,ko04912,GnRH signaling pathway;K08523,ko05205,Proteoglycans in cancer E230025N22Rik 2.82709306731922 2.67843162329501 2.26640416992258 1.18594638615031 1.37446967822141 1.3426629062378 1.00286065653234 2.01270641765196 54.0833600153112 1.60768805286823e-05 0.00032120951097102 G5E8S3,Putative uncharacterized protein E230025N22 NP_766419.2,uncharacterized protein LOC240216;XP_011245225.1,- - IPR027417,P-loop containing nucleoside triphosphate hydrolase ENOG410IJMJ,-;ENOG4111TEI,- GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0003674,molecular_function,molecular_function - Gm14963 0.930405561097659 1.02928867142202 0.978150978731248 0.335520045735915 0.261472002629487 0.29628864633038 1.74852119668404 0.805672434217906 74.2017096909907 3.67470047999624e-06 0.000102577280608612 Q4YIL0,Uncharacterized protein XP_668908.1,- - - - - - Slc15a3 26.1884431388244 28.2172050518397 29.6287665149741 6.75452646643136 7.96099494230166 7.69007673211004 1.92612862106812 6.6151028583397 568.596409304975 1.11748693652396e-10 4.78633623499917e-08 A0A1A6G050,Uncharacterized protein - PF00854,POT family IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain;IPR000109,Proton-dependent oligopeptide transporter family - GO:0055085,biological_process,transmembrane transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Tmem132a 5.6181640402404 5.08880737604649 4.34454473467588 2.36539099616996 2.70046059100222 2.3549033677004 1.03114934338553 3.94092672174826 115.452636524518 4.26685737842664e-07 1.99595724330087e-05 G3V963,RCG47487, isoform CRA_b - PF16070,Transmembrane protein family 132;PF15705,Mature oligodendrocyte transmembrane protein, TMEM132D, N-term;PF15706,Mature oligodendrocyte transmembrane protein, TMEM132D, C-term IPR026307,Transmembrane protein 132;IPR031436,Transmembrane protein TMEM132, C-terminal;IPR031435,Transmembrane protein TMEM132, N-terminal;IPR031437,Transmembrane protein family 132, middle domain ENOG410XQCD,-;KOG4789,Uncharacterized conserved protein GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Cd274 12.086984657184 12.1113008747488 14.0414438357434 5.87316234354317 5.81684968411821 5.63482481476381 1.16412070495386 5.07798936509173 196.604349661825 2.88968270998172e-08 2.69428511721153e-06 Q3U472,CD274 antigen NP_068693.1,programmed cell death 1 ligand 1 precursor PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain IPR007110,Immunoglobulin-like domain;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain ENOG410IIBU,-;ENOG4111V14,- GO:0006955,biological_process,immune response;GO:0009986,cellular_component,cell surface;GO:1903556,biological_process,negative regulation of tumor necrosis factor superfamily cytokine production;GO:0007165,biological_process,signal transduction;GO:0070062,cellular_component,extracellular exosome;GO:0034097,biological_process,response to cytokine;GO:0009897,cellular_component,external side of plasma membrane;GO:0032693,biological_process,negative regulation of interleukin-10 production;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0046007,biological_process,negative regulation of activated T cell proliferation;GO:1905404,biological_process,positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process;GO:0031295,biological_process,T cell costimulation;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:0016020,cellular_component,membrane;GO:2001181,biological_process,positive regulation of interleukin-10 secretion;GO:0032689,biological_process,negative regulation of interferon-gamma production;GO:1901998,biological_process,toxin transport;GO:0016021,cellular_component,integral component of membrane;GO:0030335,biological_process,positive regulation of cell migration K06745,ko04514,Cell adhesion molecules (CAMs) Gm26902 0.304526668764968 0.37368959090562 0.220395867415486 0.0331195599672945 0.0774305837840041 0.0438704768067325 2.49115314379746 -0.384122134851399 39.9782190250485 6.17487189110537e-05 0.000916931680817879 G3HQY5,Cholesterol 25-hydroxylase XP_003506010.1,cholesterol 25-hydroxylase;XP_007633233.1,- PF04116,atty acid hydroxylase superfamily IPR006694,Fatty acid hydroxylase - GO:0008203,biological_process,cholesterol metabolic process;GO:0035754,biological_process,B cell chemotaxis;GO:0001567,molecular_function,cholesterol 25-hydroxylase activity;GO:0016020,cellular_component,membrane;GO:0008395,molecular_function,steroid hydroxylase activity;GO:0008610,biological_process,lipid biosynthetic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane K10223,ko00120,Primary bile acid biosynthesis Ifit2 14.2741867746411 14.8525289538194 16.7461123999169 6.07266993615757 6.48431352528428 6.93417180924179 1.25516803814833 5.42868705477092 205.382165817692 2.30861474763184e-08 2.29288940080014e-06 Q6GTM0,Ifit2 protein XP_006526769.1,-;XP_006526768.1,-;NP_032358.1,interferon-induced protein with tetratricopeptide repeats 2 PF14559,Tetratricopeptide repeat IPR024124,Interferon-induced protein with tetratricopeptide repeats 2;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat GO:0035457,biological_process,cellular response to interferon-alpha;GO:0009615,biological_process,response to virus;GO:0005737,cellular_component,cytoplasm;GO:0005783,cellular_component,endoplasmic reticulum;GO:0032091,biological_process,negative regulation of protein binding;GO:0043065,biological_process,positive regulation of apoptotic process - Ifit3 10.3009126988026 10.3316968606188 11.8138752605248 0.878285179075389 1.47841386275957 1.36503805656066 3.11744629943642 3.41955518297616 413.616762271422 6.00614549719428e-10 1.46599248672648e-07 Q5FW82,Interferon-induced protein with tetratricopeptide repeats 3 NP_034631.1,interferon-induced protein with tetratricopeptide repeats 3 PF13181,Tetratricopeptide repeat;PF14559,Tetratricopeptide repeat IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR024122,Interferon-induced protein with tetratricopeptide repeats 3;IPR013026,Tetratricopeptide repeat-containing domain KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat GO:0035457,biological_process,cellular response to interferon-alpha;GO:0035458,biological_process,cellular response to interferon-beta;GO:0035634,biological_process,response to stilbenoid - Ifit3b 1.09604223532991 1.31646021074877 1.06067715152377 0.122608610998924 0.119436675486826 0.13534042094877 3.20238000286947 0.488602608042547 142.078812124876 1.50983651589753e-07 8.88146750510364e-06 E9PV48,Interferon-induced protein with tetratricopeptide repeats 3B NP_001005858.2,interferon-induced protein with tetratricopeptide repeats 3-like PF13181,Tetratricopeptide repeat;PF14559,Tetratricopeptide repeat IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR024122,Interferon-induced protein with tetratricopeptide repeats 3;IPR013026,Tetratricopeptide repeat-containing domain KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat GO:0035457,biological_process,cellular response to interferon-alpha;GO:0051607,biological_process,defense response to virus;GO:0005737,cellular_component,cytoplasm;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding - Ifit1bl2 0.874266792150807 0.821739747866115 0.856212089142122 0.0728295877629488 0.156080003606188 0.112549206610204 2.8573169368381 0.798826430634109 133.241824188168 2.08568920042438e-07 1.16790155641385e-05 Q3U687,Interferon-induced protein with tetratricopeptide repeats 1B-like 2 XP_017173534.1,-;NP_444447.1,interferon induced protein with tetratricopeptide repeats 1B like 2 PF13432,Tetratricopeptide repeat;PF13176,Tetratricopeptide repeat IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat GO:0005737,cellular_component,cytoplasm;GO:0005829,cellular_component,cytosol;GO:0003723,molecular_function,RNA binding;GO:0051607,biological_process,defense response to virus - Ifit1 5.3528740839047 5.37659877781813 5.87763250091369 0.715524650031373 1.04327216539698 0.937599301753527 2.62258712898465 3.12173775248942 385.939471865895 8.64735573519732e-10 1.85188527666585e-07 Q3UNG3,Uncharacterized protein - PF13181,Tetratricopeptide repeat;PF13432,Tetratricopeptide repeat IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat - - Pik3ap1 68.9300093587433 67.8857791536261 65.0436329423901 31.0389676792688 31.6061871651563 31.0946557958015 1.12571452636226 7.01388902188799 607.824512071526 7.84471230231025e-11 3.73965558128765e-08 F1M784,Phosphoinositide-3-kinase adaptor protein 1 XP_008758636.1,phosphoinositide 3-kinase adapter protein 1 isoform X1;XP_017444534.1,- PF14545,of, BCAP, and BANK (DBB) motif, IPR017893,DBB domain;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily ENOG410IKKC,-;ENOG4110NCP,- GO:0036312,molecular_function,phosphatidylinositol 3-kinase regulatory subunit binding;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0050727,biological_process,regulation of inflammatory response;GO:0005737,cellular_component,cytoplasm;GO:0034142,biological_process,toll-like receptor 4 signaling pathway;GO:0034122,biological_process,negative regulation of toll-like receptor signaling pathway;GO:0034162,biological_process,toll-like receptor 9 signaling pathway;GO:0043122,biological_process,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0034134,biological_process,toll-like receptor 2 signaling pathway;GO:0043408,biological_process,regulation of MAPK cascade;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0034123,biological_process,positive regulation of toll-like receptor signaling pathway;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0034154,biological_process,toll-like receptor 7 signaling pathway - Frat2 1.18827875053947 1.23903109271329 1.08233646615461 2.49642706337467 2.32130512283512 3.00617316313788 -1.12862276169591 2.06344325314828 56.0268409538158 1.36780797515679e-05 0.000282307810803341 M0R5Z2,FRAT2, WNT-signaling pathway regulator XP_017445870.1,GSK-3-binding protein FRAT2 PF05350,lycogen synthase kinase-3 binding IPR008014,Glycogen synthase kinase-3 binding protein ENOG410J5HI,-;ENOG410ZA2I,- GO:0016055,biological_process,Wnt signaling pathway - Mirt1 0.274697302087698 0.298741303282739 0.295072011042552 0.1273635155806 0.0937406963654685 0.15621008881437 1.2370207772506 0.935100872134554 33.0825331974203 0.000138115343173248 0.00171468196877948 F6ZQC6,Predicted gene 10134 - - - ENOG410Z673,- GO:0016020,cellular_component,membrane;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0003674,molecular_function,molecular_function - Dusp5 7.14190769714137 5.35942322976121 5.1028461051876 2.35499758287461 2.24094692381267 1.46668955981684 1.54741555988036 3.30139517252643 88.6919736767827 1.94928999064769e-06 6.2863455557217e-05 Q1HL35,Dual specificity protein phosphatase NP_001078859.1,dual specificity protein phosphatase 5 PF00581,Rhodanese-like domain;PF00782,ual specificity phosphatase, catalytic domain IPR008343,Mitogen-activated protein (MAP) kinase phosphatase;IPR036873,Rhodanese-like domain superfamily;IPR029021,Protein-tyrosine phosphatase-like;IPR000387,Tyrosine specific protein phosphatases domain;IPR000340,Dual specificity phosphatase, catalytic domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR001763,Rhodanese-like domain;IPR020422,Dual specificity protein phosphatase domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR024950,Dual specificity phosphatase COG2453,Predicted protein-tyrosine phosphatase;KOG1716,Dual specificity phosphatase GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0035970,biological_process,peptidyl-threonine dephosphorylation;GO:0001706,biological_process,endoderm formation;GO:0000188,biological_process,inactivation of MAPK activity;GO:0006470,biological_process,protein dephosphorylation;GO:0017017,molecular_function,MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016787,molecular_function,hydrolase activity;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity K04459,ko04010,MAPK signaling pathway Il1rn 0.429986888037545 0.338623727903776 0.235853442073244 0.066454531706734 0.103576520747383 0.0880262900479804 1.92804552570872 0.345270436569224 41.7945616283068 5.08910354951192e-05 0.000790739656377839 Q542C7,Interleukin-1 NP_001034790.1,interleukin-1 receptor antagonist protein isoform 2 precursor PF00340,Interleukin-1 / 18 IPR020877,Interleukin-1 conserved site;IPR000975,Interleukin-1 family;IPR008996,Cytokine IL1/FGF;IPR003297,Interleukin-1 receptor antagonist/Interleukin-36 ENOG410IZQ4,-;ENOG41119SQ,- GO:0045352,molecular_function,interleukin-1 Type I receptor antagonist activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005151,molecular_function,interleukin-1, Type II receptor binding;GO:0005125,molecular_function,cytokine activity;GO:0034115,biological_process,negative regulation of heterotypic cell-cell adhesion;GO:2000660,biological_process,negative regulation of interleukin-1-mediated signaling pathway;GO:0051384,biological_process,response to glucocorticoid;GO:0006955,biological_process,immune response;GO:0006954,biological_process,inflammatory response;GO:0005149,molecular_function,interleukin-1 receptor binding;GO:0005615,cellular_component,extracellular space;GO:0005152,molecular_function,interleukin-1 receptor antagonist activity;GO:0045353,molecular_function,interleukin-1 Type II receptor antagonist activity;GO:0005576,cellular_component,extracellular region;GO:0005150,molecular_function,interleukin-1, Type I receptor binding - Sapcd2 1.23507800984386 1.28814025591453 1.27473089637258 3.34641964858453 2.93556847438327 2.52191924717342 -1.18381779052049 2.89335878508022 94.3783647713503 1.15167484601742e-06 4.15390932618809e-05 B0BN66,RCG45912, isoform CRA_b NP_001102888.1,suppressor APC domain-containing protein 2 PF11414,Adenomatous polyposis coli tumour suppressor protein IPR026828,Suppressor APC domain-containing protein 1/2 ENOG4110P7W,-;ENOG410INQN,- GO:0090175,biological_process,regulation of establishment of planar polarity;GO:0043296,cellular_component,apical junction complex;GO:0005730,cellular_component,nucleolus;GO:0000132,biological_process,establishment of mitotic spindle orientation;GO:0098725,biological_process,symmetric cell division;GO:1904777,biological_process,negative regulation of protein localization to cell cortex;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0045179,cellular_component,apical cortex;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus - Ntng2 0.6749705137012 0.637510997941292 0.69525782054768 0.338018727064703 0.203551226393589 0.230655353997904 1.41671702584685 0.967963976645232 44.2752674112342 3.95011847510355e-05 0.000655451862224809 A0A1U8CNT3,netrin-G2 isoform X3 XP_012980205.1,- - IPR013032,EGF-like, conserved site;IPR002049,Laminin EGF domain;IPR008211,Laminin, N-terminal;IPR038684,Laminin, N-terminal domain superfamily;IPR000742,EGF-like domain - - - Ptges 3.85568515390252 3.58731703751244 3.54230150597923 1.29439261166506 1.08164478436302 1.17058618983927 1.65474666673338 3.27102009474714 287.09004349451 4.07177930948133e-09 6.15585198142215e-07 Q3UDM3,Uncharacterized protein - PF01124,MAPEG family IPR023352,Membrane associated eicosanoid/glutathione metabolism-like domain superfamily;IPR001129,Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein ENOG4111VJG,-;ENOG410IY81,- GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Lcn2 19.7706654507525 20.7221455144775 20.446888401467 2.05672088599034 2.80491773160065 1.71303925867296 3.21797002961005 4.89715038208085 708.966360135741 5.04628608220731e-11 2.831858086548e-08 A0A0A6YW77,Neutrophil gelatinase-associated lipocalin - PF00061,Lipocalin / cytosolic fatty-acid binding protein family IPR003087,Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12;IPR002345,Lipocalin;IPR022272,Lipocalin family conserved site;IPR000566,Lipocalin/cytosolic fatty-acid binding domain;IPR012674,Calycin ENOG410JAXJ,-;ENOG4111A75,- GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0045087,biological_process,innate immune response;GO:0009615,biological_process,response to virus;GO:0015891,biological_process,siderophore transport;GO:0005576,cellular_component,extracellular region;GO:0005506,molecular_function,iron ion binding;GO:0036094,molecular_function,small molecule binding;GO:0005615,cellular_component,extracellular space - Traf1 3.50119917721573 3.28405994290429 3.47246322077264 0.792458422376537 1.02927626000667 0.988311952500372 1.87651603731669 4.2775932424255 384.107925301388 8.86635723864036e-10 1.8695737278893e-07 Q3UM74,Uncharacterized protein - PF16673,TNF receptor-associated factor BIRC3 binding domain IPR008974,TRAF-like;IPR037306,TNF receptor-associated factor 1, MATH domain;IPR002083,MATH/TRAF domain;IPR032070,TNF receptor-associated factor, BIRC3 binding domain;IPR012227,TNF receptor-associated factor TRAF;IPR027136,TNF receptor-associated factor 1 ENOG410YE68,-;ENOG410ISDN,- GO:0042981,biological_process,regulation of apoptotic process;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0008270,molecular_function,zinc ion binding;GO:0007165,biological_process,signal transduction - Ifih1 9.92584132633651 9.25854918994225 9.11335967016513 3.62645187461607 3.74473838635977 3.86544839745905 1.34970248023239 5.75619945858541 618.381480363458 7.15959628237675e-11 3.63442320912058e-08 D2CGM4,Melanoma differentiation-associated protein 5 NP_082111.2,interferon-induced helicase C domain-containing protein 1 isoform 1 PF16739,Caspase recruitment domain;PF00271,Helicase conserved C-terminal domain;PF11648,C-terminal domain of RIG-I;PF04851,Type III restriction enzyme, res subunit IPR006935,Helicase/UvrB, N-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR038557,RIG-I-like receptor, C-terminal domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR031964,Caspase recruitment domain;IPR011029,Death-like domain superfamily;IPR021673,RIG-I-like receptor, C-terminal regulatory domain;IPR001650,Helicase, C-terminal KOG0354,DEAD-box like helicase;COG1111,ERCC4-like helicases GO:0051607,biological_process,defense response to virus;GO:2000778,biological_process,positive regulation of interleukin-6 secretion;GO:0039530,biological_process,MDA-5 signaling pathway;GO:1904469,biological_process,positive regulation of tumor necrosis factor secretion;GO:0005524,molecular_function,ATP binding;GO:0016787,molecular_function,hydrolase activity;GO:0003727,molecular_function,single-stranded RNA binding;GO:0060760,biological_process,positive regulation of response to cytokine stimulus;GO:0005737,cellular_component,cytoplasm;GO:0071360,biological_process,cellular response to exogenous dsRNA;GO:0035549,biological_process,positive regulation of interferon-beta secretion;GO:0003725,molecular_function,double-stranded RNA binding;GO:1902741,biological_process,positive regulation of interferon-alpha secretion;GO:0042802,molecular_function,identical protein binding;GO:0003677,molecular_function,DNA binding;GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0043021,molecular_function,ribonucleoprotein complex binding;GO:0008270,molecular_function,zinc ion binding;GO:0016925,biological_process,protein sumoylation;GO:0032727,biological_process,positive regulation of interferon-alpha production;GO:0046872,molecular_function,metal ion binding;GO:0009615,biological_process,response to virus;GO:0045087,biological_process,innate immune response K12647,ko04622,RIG-I-like receptor signaling pathway;K12647,ko05168,Herpes simplex infection;K12647,ko05162,Measles;K12647,ko05164,Influenza A;K12647,ko05161,Hepatitis B Calcrl 28.9421347562976 26.5451117700749 28.2330266280237 13.2478579069915 14.47331774232 14.3712564973049 1.00996073201272 6.6826742846763 294.602495397542 3.55858746448141e-09 5.73050043549715e-07 A2AR99,Calcitonin receptor-like XP_006499981.1,-;NP_061252.2,calcitonin gene-related peptide type 1 receptor precursor PF00002,7 transmembrane receptor (Secretin family);PF02793,Hormone receptor domain IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR003289,GPCR, family 2, calcitonin gene-related peptide, type 1 receptor;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR003287,GPCR, family 2, calcitonin receptor family KOG4564,Adenylate cyclase-coupled calcitonin receptor;ENOG410XRS2,- GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0007189,biological_process,adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0016020,cellular_component,membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0001605,molecular_function,adrenomedullin receptor activity;GO:0005886,cellular_component,plasma membrane;GO:0004948,molecular_function,calcitonin receptor activity;GO:1990410,biological_process,adrenomedullin receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0031623,biological_process,receptor internalization;GO:0007507,biological_process,heart development;GO:0001635,molecular_function,calcitonin gene-related peptide receptor activity;GO:0005737,cellular_component,cytoplasm;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0006816,biological_process,calcium ion transport;GO:1990409,molecular_function,adrenomedullin binding;GO:0005768,cellular_component,endosome;GO:0004871,molecular_function,signal transducer activity;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0001525,biological_process,angiogenesis;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007165,biological_process,signal transduction;GO:0071329,biological_process,cellular response to sucrose stimulus;GO:1990406,cellular_component,CGRP receptor complex;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0015031,biological_process,protein transport;GO:0005764,cellular_component,lysosome;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0008565,molecular_function,protein transporter activity;GO:1903143,cellular_component,adrenomedullin receptor complex;GO:0045986,biological_process,negative regulation of smooth muscle contraction;GO:1990408,biological_process,calcitonin gene-related peptide receptor signaling pathway K04577,ko04080,Neuroactive ligand-receptor interaction;K04577,ko04270,Vascular smooth muscle contraction Gm10801 0.124267827134911 4.1615301254501 2.91394821847189 0.121635526784647 0.47395506145566 1.18154335748926 2.09109158644095 -0.152610782259748 5.76978687218178 0.0402875255128361 0.137484218798139 F7C7Q0,Predicted gene 10801 - - - - GO:0003674,molecular_function,molecular_function;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Hdc 0.597979351609907 0.565767312306641 0.493791611290067 0.163119923852067 0.16450817722399 0.211833496554656 1.63122429141421 1.29389112549798 82.7354939914168 2.18139801190791e-06 6.79505480709315e-05 Q7TMW5,Histidine decarboxylase - PF00282,Pyridoxal-dependent decarboxylase conserved domain IPR010977,Aromatic-L-amino-acid decarboxylase;IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR002129,Pyridoxal phosphate-dependent decarboxylase;IPR015424,Pyridoxal phosphate-dependent transferase;IPR015422,Pyridoxal phosphate-dependent transferase domain 1 COG0076,Glutamate decarboxylase and related PLP-dependent proteins;KOG0628,Aromatic-L-amino-acid/L-histidine decarboxylase GO:0006520,biological_process,cellular amino acid metabolic process;GO:0019752,biological_process,carboxylic acid metabolic process;GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0003824,molecular_function,catalytic activity;GO:0016831,molecular_function,carboxy-lyase activity - Gm14023 0.562659044366042 0.476075029344143 0.702445312631817 0.103263849802575 0.10729852935369 0.0911895031659314 2.4898782861322 -0.486496154045877 44.4066042920506 3.89876276313477e-05 0.000648500514945694 Q3U0Y6,Interleukin-1 NP_034684.2,interleukin-1 alpha precursor;XP_006498856.1,- PF02394,Interleukin-1 propeptide;PF00340,Interleukin-1 / 18 IPR008996,Cytokine IL1/FGF;IPR020877,Interleukin-1 conserved site;IPR000975,Interleukin-1 family;IPR003295,Interleukin-1 alpha;IPR003502,Interleukin-1 propeptide ENOG411151X,-;ENOG410JAAI,- GO:0070498,biological_process,interleukin-1-mediated signaling pathway;GO:0001660,biological_process,fever generation;GO:0010628,biological_process,positive regulation of gene expression;GO:0002248,biological_process,connective tissue replacement involved in inflammatory response wound healing;GO:0046688,biological_process,response to copper ion;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0071639,biological_process,positive regulation of monocyte chemotactic protein-1 production;GO:0006955,biological_process,immune response;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0006954,biological_process,inflammatory response;GO:0005829,cellular_component,cytosol;GO:0035234,biological_process,ectopic germ cell programmed cell death;GO:0005149,molecular_function,interleukin-1 receptor binding;GO:0045086,biological_process,positive regulation of interleukin-2 biosynthetic process;GO:0050714,biological_process,positive regulation of protein secretion;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0034605,biological_process,cellular response to heat;GO:0005507,molecular_function,copper ion binding;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:2000391,biological_process,positive regulation of neutrophil extravasation;GO:0005125,molecular_function,cytokine activity;GO:0051781,biological_process,positive regulation of cell division;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045840,biological_process,positive regulation of mitotic nuclear division;GO:0005737,cellular_component,cytoplasm;GO:0050715,biological_process,positive regulation of cytokine secretion K04383,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04383,ko05140,Leishmaniasis;K04383,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04383,ko05132,Salmonella infection;K04383,ko05321,Inflammatory bowel disease (IBD);K04383,ko04940,Type I diabetes mellitus;K04383,ko05323,Rheumatoid arthritis;K04383,ko05162,Measles;K04383,ko04640,Hematopoietic cell lineage;K04383,ko04010,MAPK signaling pathway;K04383,ko04380,Osteoclast differentiation;K04383,ko05152,Tuberculosis;K04383,ko05020,Prion diseases;K04383,ko05164,Influenza A;K04383,ko05332,Graft-versus-host disease;K04383,ko05133,Pertussis;K04383,ko04060,Cytokine-cytokine receptor interaction Il1a 1.07875049938391 0.768630281205813 1.04709250403718 0 0.0968078423398794 0.109698416169216 3.66978439565357 0.172316392841943 68.335111670574 5.42877443285065e-06 0.000139599966935555 Q3U0Y6,Interleukin-1 NP_034684.2,interleukin-1 alpha precursor;XP_006498856.1,- PF02394,Interleukin-1 propeptide;PF00340,Interleukin-1 / 18 IPR008996,Cytokine IL1/FGF;IPR020877,Interleukin-1 conserved site;IPR000975,Interleukin-1 family;IPR003295,Interleukin-1 alpha;IPR003502,Interleukin-1 propeptide ENOG411151X,-;ENOG410JAAI,- GO:0070498,biological_process,interleukin-1-mediated signaling pathway;GO:0001660,biological_process,fever generation;GO:0010628,biological_process,positive regulation of gene expression;GO:0002248,biological_process,connective tissue replacement involved in inflammatory response wound healing;GO:0046688,biological_process,response to copper ion;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0071639,biological_process,positive regulation of monocyte chemotactic protein-1 production;GO:0006955,biological_process,immune response;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0006954,biological_process,inflammatory response;GO:0005829,cellular_component,cytosol;GO:0035234,biological_process,ectopic germ cell programmed cell death;GO:0005149,molecular_function,interleukin-1 receptor binding;GO:0045086,biological_process,positive regulation of interleukin-2 biosynthetic process;GO:0050714,biological_process,positive regulation of protein secretion;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0034605,biological_process,cellular response to heat;GO:0005507,molecular_function,copper ion binding;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:2000391,biological_process,positive regulation of neutrophil extravasation;GO:0005125,molecular_function,cytokine activity;GO:0051781,biological_process,positive regulation of cell division;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045840,biological_process,positive regulation of mitotic nuclear division;GO:0005737,cellular_component,cytoplasm;GO:0050715,biological_process,positive regulation of cytokine secretion K04383,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04383,ko05140,Leishmaniasis;K04383,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04383,ko05132,Salmonella infection;K04383,ko05321,Inflammatory bowel disease (IBD);K04383,ko04940,Type I diabetes mellitus;K04383,ko05323,Rheumatoid arthritis;K04383,ko05162,Measles;K04383,ko04640,Hematopoietic cell lineage;K04383,ko04010,MAPK signaling pathway;K04383,ko04380,Osteoclast differentiation;K04383,ko05152,Tuberculosis;K04383,ko05020,Prion diseases;K04383,ko05164,Influenza A;K04383,ko05332,Graft-versus-host disease;K04383,ko05133,Pertussis;K04383,ko04060,Cytokine-cytokine receptor interaction Il1b 1.67497652264066 1.7082754061248 2.16776151333969 0.321469876766975 0.125261327201706 0.170328794062427 3.22209153846571 1.0555814107322 122.771629358838 3.14179909471506e-07 1.58898518052268e-05 Q5BKB0,Multifunctional fusion protein NP_113700.2,interleukin-1 beta precursor PF02394,Interleukin-1 propeptide;PF00340,Interleukin-1 / 18 IPR020877,Interleukin-1 conserved site;IPR003296,Interleukin-1 beta;IPR000975,Interleukin-1 family;IPR008996,Cytokine IL1/FGF;IPR003502,Interleukin-1 propeptide ENOG410XU2E,-;ENOG410IGSZ,- GO:0000187,biological_process,activation of MAPK activity;GO:0009743,biological_process,response to carbohydrate;GO:0050766,biological_process,positive regulation of phagocytosis;GO:0032757,biological_process,positive regulation of interleukin-8 production;GO:0070164,biological_process,negative regulation of adiponectin secretion;GO:0005576,cellular_component,extracellular region;GO:0006955,biological_process,immune response;GO:0051781,biological_process,positive regulation of cell division;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0030730,biological_process,sequestering of triglyceride;GO:0034116,biological_process,positive regulation of heterotypic cell-cell adhesion;GO:0030335,biological_process,positive regulation of cell migration;GO:0032635,biological_process,interleukin-6 production;GO:0005149,molecular_function,interleukin-1 receptor binding;GO:0035690,biological_process,cellular response to drug;GO:0050995,biological_process,negative regulation of lipid catabolic process;GO:0070372,biological_process,regulation of ERK1 and ERK2 cascade;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0005178,molecular_function,integrin binding;GO:0042346,-,-;GO:2000778,biological_process,positive regulation of interleukin-6 secretion;GO:0050999,biological_process,regulation of nitric-oxide synthase activity;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0035505,biological_process,positive regulation of myosin light chain kinase activity;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:1900745,biological_process,positive regulation of p38MAPK cascade;GO:0060559,biological_process,positive regulation of calcidiol 1-monooxygenase activity;GO:0005615,cellular_component,extracellular space;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0071310,biological_process,cellular response to organic substance;GO:0005776,cellular_component,autophagosome;GO:0030141,cellular_component,secretory granule;GO:0035234,biological_process,ectopic germ cell programmed cell death;GO:0010628,biological_process,positive regulation of gene expression;GO:0032611,biological_process,interleukin-1 beta production;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0032308,biological_process,positive regulation of prostaglandin secretion;GO:0030213,biological_process,hyaluronan biosynthetic process;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005125,molecular_function,cytokine activity;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0045840,biological_process,positive regulation of mitotic nuclear division;GO:0045833,biological_process,negative regulation of lipid metabolic process;GO:0050691,biological_process,regulation of defense response to virus by host;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0031663,biological_process,lipopolysaccharide-mediated signaling pathway;GO:0071639,biological_process,positive regulation of monocyte chemotactic protein-1 production;GO:0050796,biological_process,regulation of insulin secretion;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0006954,biological_process,inflammatory response;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0045086,biological_process,positive regulation of interleukin-2 biosynthetic process;GO:0000165,biological_process,MAPK cascade;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0045410,biological_process,positive regulation of interleukin-6 biosynthetic process;GO:0045429,biological_process,positive regulation of nitric oxide biosynthetic process;GO:0031982,cellular_component,vesicle;GO:0019904,molecular_function,protein domain specific binding;GO:0050996,biological_process,positive regulation of lipid catabolic process;GO:0043122,biological_process,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0001934,biological_process,positive regulation of protein phosphorylation;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0001660,biological_process,fever generation;GO:0010829,biological_process,negative regulation of glucose transmembrane transport;GO:0070487,biological_process,monocyte aggregation;GO:0045080,biological_process,positive regulation of chemokine biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0032725,biological_process,positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0050900,biological_process,leukocyte migration;GO:0030593,biological_process,neutrophil chemotaxis;GO:0031622,biological_process,positive regulation of fever generation;GO:0046627,biological_process,negative regulation of insulin receptor signaling pathway;GO:0005829,cellular_component,cytosol;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0050805,biological_process,negative regulation of synaptic transmission;GO:0043491,biological_process,protein kinase B signaling;GO:0051044,biological_process,positive regulation of membrane protein ectodomain proteolysis;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0032496,biological_process,response to lipopolysaccharide;GO:0033198,biological_process,response to ATP;GO:0070062,cellular_component,extracellular exosome;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0005764,cellular_component,lysosome;GO:0032729,biological_process,positive regulation of interferon-gamma production;GO:1903140,biological_process,regulation of establishment of endothelial barrier K04519,ko05142,Chagas disease (American trypanosomiasis);K04519,ko04621,NOD-like receptor signaling pathway;K04519,ko05140,Leishmaniasis;K04519,ko05168,Herpes simplex infection;K04519,ko04668,TNF signaling pathway;K04519,ko04940,Type I diabetes mellitus;K04519,ko05134,Legionellosis;K04519,ko05143,African trypanosomiasis;K04519,ko05133,Pertussis;K04519,ko05010,Alzheimer's disease;K04519,ko04380,Osteoclast differentiation;K04519,ko05146,Amoebiasis;K04519,ko04640,Hematopoietic cell lineage;K04519,ko05132,Salmonella infection;K04519,ko04060,Cytokine-cytokine receptor interaction;K04519,ko04623,Cytosolic DNA-sensing pathway;K04519,ko04750,Inflammatory mediator regulation of TRP channels;K04519,ko05323,Rheumatoid arthritis;K04519,ko04620,Toll-like receptor signaling pathway;K04519,ko05164,Influenza A;K04519,ko04064,NF-kappa B signaling pathway;K04519,ko05152,Tuberculosis;K04519,ko05144,Malaria;K04519,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04519,ko05321,Inflammatory bowel disease (IBD);K04519,ko04010,MAPK signaling pathway;K04519,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04519,ko05020,Prion diseases;K04519,ko05162,Measles;K04519,ko05332,Graft-versus-host disease Adam33 0.232224638027419 0.28128961347799 0.231934575787406 0.113652772524031 0.0442850113039771 0.0903273109780444 1.65313868175384 0.00514470505691814 26.7268030815541 0.000328707575440253 0.00340534091382019 Q6TYY9,Disintegrin and metalloprotease domain 33 - PF00200,isintegrin;PF08516,ADAM cysteine-rich;PF01421,Reprolysin (M12B) family zinc metalloprotease;PF01562,Reprolysin family propeptide IPR001590,Peptidase M12B, ADAM/reprolysin;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR001762,Disintegrin domain;IPR034027,Reprolysin domain, adamalysin-type;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR006586,ADAM, cysteine-rich;IPR018358,Disintegrin, conserved site;IPR036436,Disintegrin domain superfamily;IPR002870,Peptidase M12B, propeptide KOG3607,Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family;ENOG410XX2M,- GO:0006508,biological_process,proteolysis;GO:0016021,cellular_component,integral component of membrane;GO:0008237,molecular_function,metallopeptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0016020,cellular_component,membrane;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0008233,molecular_function,peptidase activity - Siglec1 4.88386652329963 4.96674884998361 5.02587736967293 1.18437549473971 1.45136545320685 1.31115177511618 1.92724629268861 4.49934832327548 542.911949160678 1.42760232086474e-10 5.59049068850633e-08 G3X8X6,Sialic acid binding Ig-like lectin 1, sialoadhesin, isoform CRA_b NP_035556.3,sialoadhesin precursor PF07686,Immunoglobulin V-set domain;PF00047,Immunoglobulin domain;PF08205,CD80-like C2-set immunoglobulin domain;PF13895,Immunoglobulin domain;PF07679,Immunoglobulin I-set domain IPR013106,Immunoglobulin V-set domain;IPR013151,Immunoglobulin;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set ENOG410KDW5,-;ENOG410ZJZH,- GO:0030246,molecular_function,carbohydrate binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane K06548,ko04514,Cell adhesion molecules (CAMs) Procr 14.3394426230122 14.3259487671298 13.9800647172773 5.04077745859684 5.9512513831939 5.25102174828315 1.40678132773259 4.32935110067091 335.381185798814 1.80686817373417e-09 3.43957433183341e-07 Q8K357,Procr protein XP_006499018.1,endothelial protein C receptor isoform X1 PF16497,MHC-I family domain IPR011161,MHC class I-like antigen recognition-like;IPR015669,Endothelial protein C receptor;IPR037055,MHC class I-like antigen recognition-like superfamily;IPR011162,MHC classes I/II-like antigen recognition protein ENOG41116AV,-;ENOG410IWW5,- GO:0004872,-,- - Src 0.458520136360522 0.398170904685364 0.398215145847757 0.140252357582846 0.142088929885952 0.16100896566772 1.50267751848986 0.427402964552276 45.9430083642536 3.35312762192773e-05 0.000581746420077741 H2QKB4,Tyrosine-protein kinase - PF00018,SH3 domain;PF00017,SH2 domain;PF07714,Protein tyrosine kinase IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036860,SH2 domain superfamily;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR000980,SH2 domain;IPR011009,Protein kinase-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR001452,SH3 domain;IPR000719,Protein kinase domain COG0515,Serine/threonine protein kinase;KOG0197,Tyrosine kinases GO:0038083,biological_process,peptidyl-tyrosine autophosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0071801,biological_process,regulation of podosome assembly;GO:0007417,biological_process,central nervous system development;GO:0005524,molecular_function,ATP binding;GO:0050847,biological_process,progesterone receptor signaling pathway;GO:0016301,molecular_function,kinase activity;GO:0007155,biological_process,cell adhesion;GO:0036035,biological_process,osteoclast development;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0016310,biological_process,phosphorylation;GO:0045453,biological_process,bone resorption;GO:0070851,molecular_function,growth factor receptor binding;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:2001243,biological_process,negative regulation of intrinsic apoptotic signaling pathway;GO:0042127,biological_process,regulation of cell proliferation;GO:0016740,molecular_function,transferase activity;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0051427,molecular_function,hormone receptor binding;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0045087,biological_process,innate immune response;GO:0030520,biological_process,intracellular estrogen receptor signaling pathway;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0051726,biological_process,regulation of cell cycle;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0016477,biological_process,cell migration - Tgm2 0.434937394972188 0.648855594692852 0.566601042480646 0.199558286131062 0.269561941202907 0.246714309021195 1.22857449648032 0.958264064907626 30.0595019980808 0.000205010413010486 0.00234742917353527 Q6P6R6,Transglutaminase 2, C polypeptide NP_062259.2,protein-glutamine gamma-glutamyltransferase 2 PF01841,Transglutaminase-like superfamily;PF00927,Transglutaminase family, C-terminal ig like domain;PF00868,Transglutaminase family IPR023608,Protein-glutamine gamma-glutamyltransferase, animal;IPR036238,Transglutaminase, C-terminal domain superfamily;IPR013808,Transglutaminase, active site;IPR036985,Transglutaminase-like superfamily;IPR002931,Transglutaminase-like;IPR014756,Immunoglobulin E-set;IPR008958,Transglutaminase, C-terminal;IPR001102,Transglutaminase, N-terminal;IPR013783,Immunoglobulin-like fold ENOG410IFMV,-;ENOG410XQEZ,- GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0005525,molecular_function,GTP binding;GO:0032471,biological_process,negative regulation of endoplasmic reticulum calcium ion concentration;GO:0005783,cellular_component,endoplasmic reticulum;GO:0051260,biological_process,protein homooligomerization;GO:0005886,cellular_component,plasma membrane;GO:0005925,cellular_component,focal adhesion;GO:0031226,cellular_component,intrinsic component of plasma membrane;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0031012,cellular_component,extracellular matrix;GO:0051561,biological_process,positive regulation of mitochondrial calcium ion concentration;GO:0005739,cellular_component,mitochondrion;GO:0060662,biological_process,salivary gland cavitation;GO:0005829,cellular_component,cytosol;GO:0003810,molecular_function,protein-glutamine gamma-glutamyltransferase activity;GO:0001974,biological_process,blood vessel remodeling;GO:0019899,molecular_function,enzyme binding;GO:0045785,biological_process,positive regulation of cell adhesion;GO:0043277,biological_process,apoptotic cell clearance;GO:0005515,molecular_function,protein binding;GO:0050729,biological_process,positive regulation of inflammatory response;GO:0070062,cellular_component,extracellular exosome;GO:0051482,biological_process,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0060445,biological_process,branching involved in salivary gland morphogenesis;GO:0018153,biological_process,isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;GO:0046872,molecular_function,metal ion binding;GO:0019904,molecular_function,protein domain specific binding;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0018149,biological_process,peptide cross-linking K05625,ko05016,Huntington's disease Slpi 17.2500593938122 13.65246009998 14.0593885795198 5.66285533850964 6.31597334777793 6.14766657868989 1.31707046895037 3.647374035234 161.513278321475 7.88984114554841e-08 5.69148224952034e-06 Q548X8,Secretory leukocyte peptidase inhibitor, isoform CRA_a NP_035544.1,antileukoproteinase precursor PF00095,WAP-type (Whey Acidic Protein) 'four-disulfide core' IPR036645,Elafin-like superfamily;IPR008197,WAP-type 'four-disulfide core' domain ENOG410J417,-;ENOG41116TS,- GO:0019899,molecular_function,enzyme binding;GO:0010466,biological_process,negative regulation of peptidase activity;GO:0003677,molecular_function,DNA binding;GO:0032496,biological_process,response to lipopolysaccharide;GO:0006508,biological_process,proteolysis;GO:0045087,biological_process,innate immune response;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0031012,cellular_component,extracellular matrix;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0030414,molecular_function,peptidase inhibitor activity;GO:0006955,biological_process,immune response;GO:0032091,biological_process,negative regulation of protein binding;GO:0045071,biological_process,negative regulation of viral genome replication;GO:0003729,molecular_function,mRNA binding;GO:0005576,cellular_component,extracellular region;GO:0035821,biological_process,modification of morphology or physiology of other organism;GO:0019731,biological_process,antibacterial humoral response;GO:0008233,molecular_function,peptidase activity;GO:0005615,cellular_component,extracellular space - Mmp9 2.10598677599418 1.80318877914449 1.72141689990164 0.398417357018262 0.431983454713585 0.413019651383644 2.18232679097782 2.05990814631138 233.542896320253 1.18967622122297e-08 1.36273981586305e-06 Q3TTU7,Uncharacterized protein - PF00413,Matrixin;PF04886,PT repeat;PF01471,Putative peptidoglycan binding domain;PF00040,ibronectin type II domain;PF00045,Hemopexin IPR001818,Peptidase M10, metallopeptidase;IPR018486,Hemopexin, conserved site;IPR036375,Hemopexin-like domain superfamily;IPR036365,PGBD-like superfamily;IPR021190,Peptidase M10A;IPR000562,Fibronectin type II domain;IPR028688,Matrix metalloproteinase-9;IPR036366,PGBD superfamily;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR013806,Kringle-like fold;IPR006026,Peptidase, metallopeptidase;IPR018487,Hemopexin-like repeats;IPR006970,PT repeat;IPR000585,Hemopexin-like domain;IPR036943,Fibronectin type II domain superfamily;IPR033739,Peptidase M10A, catalytic domain;IPR021158,Peptidase M10A, cysteine switch, zinc binding site;IPR002477,Peptidoglycan binding-like KOG1565,Gelatinase A and related matrix metalloproteases;ENOG410XQ5D,- GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0001503,biological_process,ossification;GO:0008237,molecular_function,metallopeptidase activity;GO:0031012,cellular_component,extracellular matrix;GO:0046872,molecular_function,metal ion binding;GO:0050900,biological_process,leukocyte migration;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0008270,molecular_function,zinc ion binding;GO:0008233,molecular_function,peptidase activity;GO:0030574,biological_process,collagen catabolic process - Zbp1 3.93994860937118 3.98331467968419 3.73002987217636 0.364803178092577 0.460283022561869 0.567593717778916 3.06991367654014 2.96754383253188 519.332638987705 1.80591938920284e-10 6.03705637766197e-08 A2APF7,Z-DNA-binding protein 1 NP_067369.2,Z-DNA-binding protein 1 isoform 1 PF02295,Adenosine deaminase z-alpha domain;PF12721,RIP homotypic interaction motif IPR025735,RHIM domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000607,Double-stranded RNA-specific adenosine deaminase (DRADA) ENOG410J2S4,-;ENOG411196S,- GO:0003723,molecular_function,RNA binding;GO:0005515,molecular_function,protein binding;GO:0003726,molecular_function,double-stranded RNA adenosine deaminase activity - Helz2 14.9773289359978 15.3629699503885 14.3662777984164 6.39683229385488 6.50173107255895 6.30156457327606 1.23898544488145 6.94514135535327 690.226088687949 3.9930433813686e-11 2.43125171111597e-08 A2AS03,Helicase with zinc finger domain 2 XP_006500664.1,helicase with zinc finger domain 2 isoform X3 PF13087,AAA domain;PF13086,AAA domain;PF00773,RNB domain IPR031191,Helicase with zinc finger domain 2;IPR003593,AAA+ ATPase domain;IPR012340,Nucleic acid-binding, OB-fold;IPR036236,Zinc finger C2H2 superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase KOG2102,Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3;KOG1804,RNA helicase;COG1112,Superfamily I DNA and RNA helicases and helicase subunits;COG0557,Exoribonuclease R GO:1903506,biological_process,regulation of nucleic acid-templated transcription;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity - Fabp4 0.878982411937556 0.785349926178513 0.908783137861584 0.150222178769009 0.159639129632648 0.217075302034115 2.290080237802 1.28376264823627 132.032723737787 2.18333091871032e-07 1.2017965289897e-05 Q542H7,Fabp4 protein NP_077717.1,fatty acid-binding protein, adipocyte PF00061,Lipocalin / cytosolic fatty-acid binding protein family IPR031259,Intracellular lipid binding protein;IPR033073,Fatty acid-binding protein 4;IPR000463,Cytosolic fatty-acid binding;IPR000566,Lipocalin/cytosolic fatty-acid binding domain;IPR012674,Calycin ENOG4111US8,-;KOG4015,Fatty acid-binding protein FABP GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0001816,biological_process,cytokine production;GO:0050729,biological_process,positive regulation of inflammatory response;GO:0050727,biological_process,regulation of inflammatory response;GO:0050872,biological_process,white fat cell differentiation;GO:0071285,biological_process,cellular response to lithium ion;GO:0005504,molecular_function,fatty acid binding;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0050873,biological_process,brown fat cell differentiation;GO:0008289,molecular_function,lipid binding;GO:0042632,biological_process,cholesterol homeostasis K08753,ko03320,PPAR signaling pathway;K08753,ko04923,Regulation of lipolysis in adipocytes Gm9845 7.75032254318333 6.64162795514089 6.3671555275417 4.51068468557915 3.1157393605259 2.71586128994187 1.03417788425616 1.67879820030404 32.1218073501389 0.000156098129530362 0.00189896146679862 A0A2C9F2D9,CASP8 and FADD-like apoptosis regulator - - IPR001875,Death effector domain;IPR001309,Peptidase C14, p20 domain;IPR015917,Peptidase C14A, caspase catalytic domain;IPR029030,Caspase-like domain superfamily;IPR011029,Death-like domain superfamily - GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0042981,biological_process,regulation of apoptotic process;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0006508,biological_process,proteolysis - Mgarp 0.696909846225392 0.496561541695927 0.684197485259648 0.266927309867034 0.32358267185594 0.314288350534154 1.0330768604228 0.0883067954430232 15.0070771048633 0.00268542491834595 0.0177723003046111 D3Z134,Protein MGARP - PF14962,Mitochondria Localisation Sequence IPR032773,Protein MGARP, N-terminal;IPR026093,Protein MGARP ENOG410IWK1,-;ENOG410Y7BU,- GO:0097211,biological_process,cellular response to gonadotropin-releasing hormone;GO:0016021,cellular_component,integral component of membrane;GO:0008090,biological_process,retrograde axonal transport;GO:0010822,biological_process,positive regulation of mitochondrion organization;GO:0071383,biological_process,cellular response to steroid hormone stimulus;GO:0031307,cellular_component,integral component of mitochondrial outer membrane;GO:0008089,biological_process,anterograde axonal transport;GO:1904115,cellular_component,axon cytoplasm;GO:0005739,cellular_component,mitochondrion;GO:0019896,biological_process,axonal transport of mitochondrion;GO:0016020,cellular_component,membrane;GO:0071456,biological_process,cellular response to hypoxia;GO:0006626,biological_process,protein targeting to mitochondrion - Gm37589 0.188175217454166 0.2122908430801 0.367709039086088 0.506520300821795 0.514349228436007 0.596392440835841 -1.04847449779541 0.760754889296532 16.3013459949248 0.00203518082537653 0.0144156012364913 - - - - - - - Kcnab1 0.160349315404619 0.171377912864469 0.177240032839285 0.107013218025362 0.0500374760563918 0.0756003747880944 1.18560135853919 0.224727949190312 17.8838482998244 0.0014773644939426 0.011174811122504 H0V469,Potassium voltage-gated channel subfamily A member regulatory beta subunit 1 - PF00248,Aldo/keto reductase family IPR005983,Potassium channel, voltage-dependent, beta subunit, KCNAB;IPR005399,Potassium channel, voltage-dependent, beta subunit, KCNAB-related;IPR036812,NADP-dependent oxidoreductase domain superfamily;IPR005400,Potassium channel, voltage-dependent, beta subunit, KCNAB1;IPR023210,NADP-dependent oxidoreductase domain COG0667,Predicted oxidoreductases (related to aryl-alcohol dehydrogenases);KOG1575,Voltage-gated shaker-like K+ channel, subunit beta/KCNAB GO:0005829,cellular_component,cytosol;GO:0034705,cellular_component,potassium channel complex;GO:0055085,biological_process,transmembrane transport;GO:0005737,cellular_component,cytoplasm;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0019904,molecular_function,protein domain specific binding;GO:1903817,biological_process,negative regulation of voltage-gated potassium channel activity;GO:0071805,biological_process,potassium ion transmembrane transport;GO:1901016,biological_process,regulation of potassium ion transmembrane transporter activity;GO:0007611,biological_process,learning or memory;GO:0008076,cellular_component,voltage-gated potassium channel complex;GO:0015459,molecular_function,potassium channel regulator activity;GO:1901379,biological_process,regulation of potassium ion transmembrane transport;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0006813,biological_process,potassium ion transport;GO:0070402,molecular_function,NADPH binding;GO:0016021,cellular_component,integral component of membrane - Gm6634 2.08307045042112 1.95423271541871 3.91972339809227 0.645666188741563 0.767996361223495 0.930277838007066 1.76783433391614 1.69037210900982 28.7015495527327 0.000380451375895143 0.00380414159055277 A0A0G2JZP4,Uncharacterized protein - PF00078,Reverse transcriptase (RNA-dependent DNA polymerase) IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR000477,Reverse transcriptase domain - GO:0003964,molecular_function,RNA-directed DNA polymerase activity;GO:0006278,biological_process,RNA-dependent DNA biosynthetic process - Gm3513 3.53958470256801 3.57286383461603 2.98866483945835 0.769912784922601 1.49998964504648 1.52975044086522 1.39545644782822 0.670207976551063 32.1056992815745 0.000156422551876232 0.00189896146679862 - - - - - - - Gbp5 0.207606097223428 0.154647085533446 0.180301552165003 0.0646572455169858 0.0215946979937007 0.032626890691281 2.22390884134814 -0.26399942553303 36.1808448760639 9.47634899117987e-05 0.00128101549535338 Q8BMN7,Guanylate-binding protein 5 NP_705792.2,guanylate-binding protein 5 PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0031410,cellular_component,cytoplasmic vesicle;GO:0072616,biological_process,interleukin-18 secretion;GO:0005525,molecular_function,GTP binding;GO:0045089,biological_process,positive regulation of innate immune response;GO:0050702,biological_process,interleukin-1 beta secretion;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:1900017,biological_process,positive regulation of cytokine production involved in inflammatory response;GO:0000166,molecular_function,nucleotide binding - Gbp7 1.49493266358805 1.51826185295245 1.43396288057802 0.491395394990345 0.502085062609387 0.530368589396676 1.56307897247372 2.51429190061432 197.009072601533 2.85933038918749e-08 2.69428511721153e-06 Q91Z40,Gbp6 protein NP_001076781.1,-;NP_663520.2,guanylate binding protein 7 PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0003674,molecular_function,molecular_function;GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0044406,biological_process,adhesion of symbiont to host;GO:0020005,cellular_component,symbiont-containing vacuole membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:0042832,biological_process,defense response to protozoan - Gm43802 2.75301032421956 3.22258306651642 2.22015102359763 1.1548691773839 1.19999171603719 0.934847491639855 1.33930975776791 0.415105780987342 30.5009059053064 0.000193164525599594 0.00224555808979477 W5PX34,Uncharacterized protein - PF02230,Phospholipase/Carboxylesterase;PF07859,alpha/beta hydrolase fold IPR003140,Phospholipase/carboxylesterase/thioesterase;IPR029058,Alpha/Beta hydrolase fold - GO:0016787,molecular_function,hydrolase activity;GO:0042997,biological_process,negative regulation of Golgi to plasma membrane protein transport;GO:0002084,biological_process,protein depalmitoylation;GO:0016298,molecular_function,lipase activity;GO:0005739,cellular_component,mitochondrion;GO:0008474,molecular_function,palmitoyl-(protein) hydrolase activity;GO:0005829,cellular_component,cytosol - Gbp3 0.90157926161463 1.33945649184602 1.96583663375827 0.375524076566384 0.42433857140802 0.38135738827831 1.85687091167292 1.61938243583605 37.6775216769549 0.000107901949420521 0.00141521925239968 D3ZQL3,Guanylate-binding protein 4 NP_001292190.1,guanylate-binding protein 4 PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0035458,biological_process,cellular response to interferon-beta;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005525,molecular_function,GTP binding;GO:0042832,biological_process,defense response to protozoan;GO:0044406,biological_process,adhesion of symbiont to host;GO:0020005,cellular_component,symbiont-containing vacuole membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding - Gbp2b 0.599021109334703 0.490045648435212 0.847794120948724 0.130296079701301 0.220003794733084 0.210945041507116 1.75572567443266 0.363321655459673 30.1568764108912 0.000202324717002358 0.00232249796585789 A4UUI2,Guanylate binding protein 1 NP_034389.2,guanylate-binding protein 1 PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding - Gbp2 0.42318233024321 0.336999056940349 0.41076323588422 0.121828906000521 0.15190674147768 0.0645502802617345 1.75583860252411 -0.435761178375805 25.2133724525848 0.000413286927970047 0.0040576723744681 Q3UDC7,Uncharacterized protein - PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity - Ifi44 8.34875422478185 8.65721004383321 9.15880216685308 1.57036644859121 1.60574026107268 1.88138421681109 2.39104849371198 5.00834778069249 718.260025769891 3.23111154264506e-11 2.18462475777463e-08 D3ZAF8,Interferon-induced protein 44 NP_001101199.1,interferon-induced protein 44;XP_006233557.1,-;XP_006233558.1,- PF07534,TLD IPR024644,Interferon-induced protein 44 family;IPR006571,TLDc domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase ENOG410IDX3,-;ENOG410XP4J,- - - Ifi44l 3.95995325887469 3.85935073608355 3.43913656017322 0.356420380810826 0.520799457064649 0.393431456246424 3.1306047974703 1.5821674454371 287.265346231388 4.05884245755759e-09 6.15585198142215e-07 F6ZI78,Interferon-induced protein 44-like - - IPR024644,Interferon-induced protein 44 family ENOG410IDX3,-;ENOG410XP4J,- - - Ddx58 18.8603660839344 19.1352769183485 18.4167038420603 8.00869012269569 7.66427687804826 7.88621913840492 1.28016662046913 6.55984017032143 687.43874663614 4.07987664932637e-11 2.43125171111597e-08 A7YY79,Ddx58 protein - PF16739,Caspase recruitment domain;PF00271,Helicase conserved C-terminal domain;PF11648,C-terminal domain of RIG-I;PF04851,Type III restriction enzyme, res subunit IPR006935,Helicase/UvrB, N-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR038557,RIG-I-like receptor, C-terminal domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR031964,Caspase recruitment domain;IPR021673,RIG-I-like receptor, C-terminal regulatory domain;IPR001650,Helicase, C-terminal KOG0354,DEAD-box like helicase;COG1111,ERCC4-like helicases GO:0046872,molecular_function,metal ion binding;GO:0016787,molecular_function,hydrolase activity;GO:0003677,molecular_function,DNA binding;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding - Abca1 2.61088347644793 2.61820593190981 2.50369535243402 1.14172835678821 1.12947932043896 1.21196478471928 1.1703728696189 4.28757653016729 276.860421511259 4.91900841119729e-09 7.02290930040314e-07 G3GTZ6,ATP-binding cassette sub-family A member 1 XP_003495905.1,ATP-binding cassette sub-family A member 1 isoform X2 PF12698,ABC-2 family transporter protein;PF00005,ABC transporter IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR020846,Major facilitator superfamily domain;IPR026082,ABC transporter A;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site - GO:0008509,molecular_function,anion transmembrane transporter activity;GO:0033344,biological_process,cholesterol efflux;GO:0032489,biological_process,regulation of Cdc42 protein signal transduction;GO:0045332,biological_process,phospholipid translocation;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0005102,molecular_function,signaling receptor binding;GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0005886,cellular_component,plasma membrane;GO:0071404,biological_process,cellular response to low-density lipoprotein particle stimulus;GO:0031267,molecular_function,small GTPase binding;GO:0005524,molecular_function,ATP binding;GO:0007040,biological_process,lysosome organization;GO:0005548,molecular_function,phospholipid transporter activity;GO:0017127,molecular_function,cholesterol transporter activity;GO:0008203,biological_process,cholesterol metabolic process;GO:0005794,cellular_component,Golgi apparatus;GO:0000166,molecular_function,nucleotide binding;GO:0034380,biological_process,high-density lipoprotein particle assembly;GO:0098656,biological_process,anion transmembrane transport;GO:0045335,cellular_component,phagocytic vesicle;GO:0032367,biological_process,intracellular cholesterol transport;GO:0034188,molecular_function,apolipoprotein A-I receptor activity;GO:0007189,biological_process,adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0051117,molecular_function,ATPase binding;GO:0060155,biological_process,platelet dense granule organization;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0006911,biological_process,phagocytosis, engulfment;GO:0071300,biological_process,cellular response to retinoic acid;GO:0045121,cellular_component,membrane raft;GO:0009897,cellular_component,external side of plasma membrane;GO:0042158,biological_process,lipoprotein biosynthetic process;GO:0090554,molecular_function,phosphatidylcholine-translocating ATPase activity;GO:0090556,molecular_function,phosphatidylserine-translocating ATPase activity;GO:0055091,biological_process,phospholipid homeostasis;GO:0050702,biological_process,interleukin-1 beta secretion;GO:0019905,molecular_function,syntaxin binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0034616,biological_process,response to laminar fluid shear stress;GO:0016197,biological_process,endosomal transport;GO:0016020,cellular_component,membrane;GO:0043691,biological_process,reverse cholesterol transport;GO:0010875,biological_process,positive regulation of cholesterol efflux;GO:0038027,biological_process,apolipoprotein A-I-mediated signaling pathway;GO:0002790,biological_process,peptide secretion;GO:0034185,molecular_function,apolipoprotein binding;GO:0034186,molecular_function,apolipoprotein A-I binding;GO:0055085,biological_process,transmembrane transport;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0006497,biological_process,protein lipidation;GO:0033700,biological_process,phospholipid efflux;GO:0016887,molecular_function,ATPase activity;GO:0042632,biological_process,cholesterol homeostasis;GO:0042157,biological_process,lipoprotein metabolic process;GO:0030139,cellular_component,endocytic vesicle K05641,ko02010,ABC transporters;K05641,ko04975,Fat digestion and absorption Slc31a2 17.2828246509755 14.9703763117153 14.3408869856784 7.05617682581118 8.27185632491153 6.9234647214324 1.07674615108056 4.55226047411523 160.427615871267 8.16488803833104e-08 5.82853934652944e-06 Q4KL43,Solute carrier family 31, member 2 NP_079562.1,probable low affinity copper uptake protein 2 isoform 1 PF04145,Ctr copper transporter family IPR007274,Ctr copper transporter KOG3386,Copper transporter;ENOG4111I8D,- GO:0006878,biological_process,cellular copper ion homeostasis;GO:1902311,biological_process,regulation of copper ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0005770,cellular_component,late endosome;GO:0005375,molecular_function,copper ion transmembrane transporter activity;GO:0055037,cellular_component,recycling endosome;GO:0035434,biological_process,copper ion transmembrane transport;GO:0016021,cellular_component,integral component of membrane - Fggy 1.32892575712241 1.4737805582113 1.39614219913095 0.587447143732012 0.596774627689139 0.602130551791242 1.25597664258361 2.57498266258397 126.032842064195 2.75609534797273e-07 1.45220132596306e-05 F1LSP9,FGGY carbohydrate kinase domain-containing NP_001013954.2,FGGY carbohydrate kinase domain-containing protein;XP_017448749.1,-;XP_017448750.1,-;XP_006238475.1,-;XP_006238472.1,- PF02782,Y family of carbohydrate kinases, C-terminal domain;PF00370,Y family of carbohydrate kinases, N-terminal domain IPR018484,Carbohydrate kinase, FGGY, N-terminal;IPR006003,FGGY carbohydrate kinase, pentulose kinase;IPR000577,Carbohydrate kinase, FGGY;IPR018485,Carbohydrate kinase, FGGY, C-terminal COG1069,Ribulose kinase;ENOG410IR1J,- GO:0005975,biological_process,carbohydrate metabolic process;GO:0008150,biological_process,biological_process;GO:0019150,molecular_function,D-ribulokinase activity;GO:0019321,biological_process,pentose metabolic process;GO:0005623,cellular_component,cell;GO:0005575,cellular_component,cellular_component;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor;GO:0070050,biological_process,neuron cellular homeostasis;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0003674,molecular_function,molecular_function - 4933421A08Rik 0.955906362576237 1.44393516627729 0.963014226047691 0.673673686807276 0.437496979805224 0.264401310766828 1.35778384084486 0.495866842504931 18.9904461655743 0.001193935458984 0.00939894532291928 - - - - - - - Gm12932 0.505088587709637 0.647793433391958 1.40370838911334 2.86745945078129 1.77228615238516 2.27022641591485 -1.37739974224332 0.106752154150179 14.2543008612542 0.00317746547137296 0.0202748332172429 - - - - - - - Zc3h12a 6.30221568842421 6.37953406683791 5.98292953670056 1.78680140942221 1.65769154041397 1.39003346984163 1.97151999149492 3.51542678269076 407.549182319381 6.49221100691558e-10 1.5081736281489e-07 A0A1A6HUI1,Uncharacterized protein - PF11977,Zc3h12a-like Ribonuclease NYN domain IPR021869,Ribonuclease Zc3h12a-like, NYN domain - - - Sdc3 5.16608891780624 4.54528629355371 5.022493929406 1.53542257888117 1.57945979271275 1.59091094252687 1.66190769539249 4.29114005742487 427.346600243206 5.05677587563843e-10 1.3493616432466e-07 G3V9B7,Syndecan NP_446345.3,syndecan-3 precursor PF01034,Syndecan domain IPR031194,Syndecan-3;IPR030479,Syndecan, conserved site;IPR001050,Syndecan;IPR003585,Neurexin/syndecan/glycophorin C;IPR027789,Syndecan/Neurexin domain ENOG410IJZ0,-;ENOG410Y2QY,- GO:0031012,cellular_component,extracellular matrix;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane K16337,ko04514,Cell adhesion molecules (CAMs) Gm26716 5.43304929044776 3.11842729113451 5.6359737430364 1.32949096263894 1.72679530824327 1.82628037906774 1.50467337824014 0.506465029546637 24.6253830441537 0.00045296649960258 0.00437308863769785 - - - - - - - Aim1l 2.51714848464457 2.55206433776844 2.33496436520978 0.980233061140924 0.82583699558739 0.889012272437901 1.48428385715931 3.56362789530537 267.130046812141 5.92555161332680e-09 8.04114954576803e-07 B7ZCC2,Crystallin beta-gamma domain-containing 2 XP_006538813.1,-;XP_006538814.1,-;NP_001156442.1,absent in melanoma 1-like protein PF00030,Beta/Gamma crystallin IPR035992,Ricin B-like lectins;IPR011024,Gamma-crystallin-like;IPR001064,Beta/gamma crystallin;IPR000772,Ricin B, lectin domain ENOG410IERF,-;ENOG4110BHM,- GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0003674,molecular_function,molecular_function - Id3 1.15400474645887 1.27075056541062 1.06297012994694 0.342290929645238 0.320098292762013 0.272041047133206 1.91843604018606 0.520201085091152 72.6539359265265 4.06215677610285e-06 0.000110837207638512 Q545W1,Id3 protein NP_032347.1,DNA-binding protein inhibitor ID-3 PF00010,Helix-loop-helix DNA-binding domain IPR026052,DNA-binding protein inhibitor;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily ENOG4112051,-;ENOG410IYKY,- GO:0046983,molecular_function,protein dimerization activity;GO:0042476,biological_process,odontogenesis;GO:0030855,biological_process,epithelial cell differentiation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:0007417,biological_process,central nervous system development;GO:0005634,cellular_component,nucleus;GO:0030182,biological_process,neuron differentiation;GO:0072750,biological_process,cellular response to leptomycin B;GO:0007507,biological_process,heart development;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0010629,biological_process,negative regulation of gene expression;GO:0007623,biological_process,circadian rhythm;GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0006275,biological_process,regulation of DNA replication;GO:1901707,molecular_function,leptomycin B binding;GO:0019904,molecular_function,protein domain specific binding;GO:0009611,biological_process,response to wounding;GO:0001656,biological_process,metanephros development;GO:0030903,biological_process,notochord development;GO:0051726,biological_process,regulation of cell cycle;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0045668,biological_process,negative regulation of osteoblast differentiation K17694,ko04350,TGF-beta signaling pathway;K17694,ko04550,Signaling pathways regulating pluripotency of stem cells Gm13012 9.07169537601319 8.48044757400467 9.95852214640375 3.90699513611867 4.92693586017499 3.95200302191078 1.11120389161071 2.56597193210947 69.5820059366683 4.98469292765965e-06 0.000130881611621654 - - - - - - - Dhrs3 58.5654272653223 54.8102639671767 48.8744213206401 25.1542435616174 26.6212801802547 25.17230104698 1.09315915552432 6.86987102811502 365.193715366177 1.15601565603162e-09 2.36482844501036e-07 A0A061IFL7,Short-chain dehydrogenase/reductase 3-like protein - PF02719,Polysaccharide biosynthesis protein;PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase IPR036291,NAD(P)-binding domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR;IPR032969,Short-chain dehydrogenase/reductase 3 - GO:0004745,molecular_function,retinol dehydrogenase activity;GO:0001523,biological_process,retinoid metabolic process;GO:0003151,biological_process,outflow tract morphogenesis;GO:0016020,cellular_component,membrane;GO:0060021,biological_process,roof of mouth development;GO:0030278,biological_process,regulation of ossification;GO:0052650,molecular_function,NADP-retinol dehydrogenase activity;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0048387,biological_process,negative regulation of retinoic acid receptor signaling pathway;GO:0042572,biological_process,retinol metabolic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0060349,biological_process,bone morphogenesis;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane - Tnfrsf1b 4.70798655301482 3.82206043553593 4.37372077631996 0.931285940012782 1.1637098816422 0.964185293296632 2.07770226889285 3.36430281287992 298.544219470635 3.32012565474621e-09 5.61798052147549e-07 Q545P4,Tumor necrosis factor receptor superfamily, member 1b NP_035740.2,tumor necrosis factor receptor superfamily member 1B precursor PF00020,TNFR/NGFR cysteine-rich region IPR033996,Tumor necrosis factor receptor 1B, N-terminal;IPR020411,Tumour necrosis factor receptor 1B;IPR001368,TNFR/NGFR cysteine-rich region ENOG410YPQW,-;ENOG410IJ06,- GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0005031,molecular_function,tumor necrosis factor-activated receptor activity;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0033209,biological_process,tumor necrosis factor-mediated signaling pathway;GO:0005634,cellular_component,nucleus;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0006955,biological_process,immune response;GO:0043196,cellular_component,varicosity;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0016021,cellular_component,integral component of membrane;GO:0006954,biological_process,inflammatory response;GO:0030424,cellular_component,axon;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0051044,biological_process,positive regulation of membrane protein ectodomain proteolysis;GO:0016020,cellular_component,membrane;GO:0032496,biological_process,response to lipopolysaccharide;GO:0050779,biological_process,RNA destabilization;GO:0045121,cellular_component,membrane raft;GO:0043025,cellular_component,neuronal cell body;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0007568,biological_process,aging;GO:0097191,biological_process,extrinsic apoptotic signaling pathway K05141,ko04060,Cytokine-cytokine receptor interaction;K05141,ko05014,Amyotrophic lateral sclerosis (ALS);K05141,ko04668,TNF signaling pathway;K05141,ko04920,Adipocytokine signaling pathway Tnfrsf9 1.67967005729156 1.11482452248367 1.29889438099898 0.427913961972733 0.403680166965026 0.318214068358607 1.82595924792891 1.3095203933565 73.1355680760707 3.93661208052955e-06 0.000108126663678834 Q3U3R1,CD137 antigen NP_001070977.1,-;XP_011248530.1,-;NP_035742.1,tumor necrosis factor receptor superfamily member 9 isoform 1 precursor PF00020,TNFR/NGFR cysteine-rich region IPR020413,Tumour necrosis factor receptor 9;IPR034020,Tumour necrosis factor receptor 9, N-terminal;IPR001368,TNFR/NGFR cysteine-rich region ENOG41129F9,-;ENOG410IW3N,- GO:0006915,biological_process,apoptotic process;GO:0009897,cellular_component,external side of plasma membrane;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0004872,-,-;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane K05146,ko04060,Cytokine-cytokine receptor interaction Isg15 59.1514857162175 61.0357751732682 54.8253961105082 9.32539038682294 9.60548924550137 9.45234685991409 2.64228695717348 4.69217542474631 1420.3724704245 8.47578561968087e-13 2.90422794258365e-09 Q4FJR9,G1p2 protein NP_056598.2,ubiquitin-like protein ISG15 precursor PF00240,Ubiquitin family IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily COG5272,Ubiquitin;KOG0001,Ubiquitin and ubiquitin-like proteins GO:0051607,biological_process,defense response to virus;GO:0030501,biological_process,positive regulation of bone mineralization;GO:0032020,biological_process,ISG15-protein conjugation;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0019941,biological_process,modification-dependent protein catabolic process;GO:0042742,biological_process,defense response to bacterium;GO:0031386,molecular_function,protein tag K12159,ko04622,RIG-I-like receptor signaling pathway Asb10 0.223203794996419 0.206748042810612 0.290771739548157 0.568037043116898 0.442673351768707 0.501618096175056 -1.03752387198054 0.195024937361288 16.4832244273751 0.00195965051108612 0.014032899636858 B5DEZ7,Ankyrin repeat and SOCS box-containing 10 NP_001102686.1,ankyrin repeat and SOCS box protein 10 PF12796,Ankyrin repeats (3 copies);PF07525,SOCS box IPR020683,Ankyrin repeat-containing domain;IPR036036,SOCS box-like domain superfamily;IPR002110,Ankyrin repeat;IPR001496,SOCS box domain;IPR036770,Ankyrin repeat-containing domain superfamily KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0035556,biological_process,intracellular signal transduction;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005634,cellular_component,nucleus - Il6 1.54771791291586 1.08439885564149 0.963315116705151 0.0757466707159746 0.196765527984887 0.111483048557471 3.14659466786837 0.777008997627111 97.005845210035 1.00699517068371e-06 3.74034574780241e-05 A2RTD1,Interleukin 6 NP_112445.1,interleukin-6 isoform 1 precursor PF00489,Interleukin-6/G-CSF/MGF family IPR009079,Four-helical cytokine-like, core;IPR030473,Interleukin-6/GCSF/MGF, conserved site;IPR003574,Interleukin-6;IPR030474,Interleukin-6/GCSF/MGF ENOG4112BXV,-;ENOG410IW11,- GO:0001878,biological_process,response to yeast;GO:0009408,biological_process,response to heat;GO:0032868,biological_process,response to insulin;GO:0002262,biological_process,myeloid cell homeostasis;GO:0071392,biological_process,cellular response to estradiol stimulus;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0009612,biological_process,response to mechanical stimulus;GO:0005576,cellular_component,extracellular region;GO:0045779,biological_process,negative regulation of bone resorption;GO:0060664,biological_process,epithelial cell proliferation involved in salivary gland morphogenesis;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0070301,biological_process,cellular response to hydrogen peroxide;GO:0046427,biological_process,positive regulation of JAK-STAT cascade;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0051592,biological_process,response to calcium ion;GO:0046849,biological_process,bone remodeling;GO:0045721,biological_process,negative regulation of gluconeogenesis;GO:0042110,biological_process,T cell activation;GO:0009611,biological_process,response to wounding;GO:0046677,biological_process,response to antibiotic;GO:0045740,biological_process,positive regulation of DNA replication;GO:0001781,biological_process,neutrophil apoptotic process;GO:0051971,biological_process,positive regulation of transmission of nerve impulse;GO:0034097,biological_process,response to cytokine;GO:0009617,biological_process,response to bacterium;GO:0005102,molecular_function,signaling receptor binding;GO:0070102,biological_process,interleukin-6-mediated signaling pathway;GO:0010976,biological_process,positive regulation of neuron projection development;GO:0046888,biological_process,negative regulation of hormone secretion;GO:0005615,cellular_component,extracellular space;GO:0048635,biological_process,negative regulation of muscle organ development;GO:0045079,biological_process,negative regulation of chemokine biosynthetic process;GO:0071347,biological_process,cellular response to interleukin-1;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0042493,biological_process,response to drug;GO:0010628,biological_process,positive regulation of gene expression;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0071864,biological_process,positive regulation of cell proliferation in bone marrow;GO:0031000,biological_process,response to caffeine;GO:2000660,biological_process,negative regulation of interleukin-1-mediated signaling pathway;GO:0031294,biological_process,lymphocyte costimulation;GO:0060445,biological_process,branching involved in salivary gland morphogenesis;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007568,biological_process,aging;GO:0010996,biological_process,response to auditory stimulus;GO:0043200,biological_process,response to amino acid;GO:0031667,biological_process,response to nutrient levels;GO:0042593,biological_process,glucose homeostasis;GO:0005138,molecular_function,interleukin-6 receptor binding;GO:0033160,biological_process,positive regulation of protein import into nucleus, translocation;GO:0071549,biological_process,cellular response to dexamethasone stimulus;GO:0045630,biological_process,positive regulation of T-helper 2 cell differentiation;GO:0042060,biological_process,wound healing;GO:0042127,biological_process,regulation of cell proliferation;GO:0042981,biological_process,regulation of apoptotic process;GO:0014070,biological_process,response to organic cyclic compound;GO:0009409,biological_process,response to cold;GO:0002526,biological_process,acute inflammatory response;GO:0031669,biological_process,cellular response to nutrient levels;GO:0045429,biological_process,positive regulation of nitric oxide biosynthetic process;GO:0008360,biological_process,regulation of cell shape;GO:1990646,biological_process,cellular response to prolactin;GO:0005125,molecular_function,cytokine activity;GO:0046716,biological_process,muscle cell cellular homeostasis;GO:0051602,biological_process,response to electrical stimulus;GO:0071345,biological_process,cellular response to cytokine stimulus;GO:1901215,biological_process,negative regulation of neuron death;GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0035729,biological_process,cellular response to hepatocyte growth factor stimulus;GO:0072540,biological_process,T-helper 17 cell lineage commitment;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:0005737,cellular_component,cytoplasm;GO:0045454,biological_process,cell redox homeostasis;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0006955,biological_process,immune response;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0045837,biological_process,negative regulation of membrane potential;GO:0050710,biological_process,negative regulation of cytokine secretion;GO:0009897,cellular_component,external side of plasma membrane;GO:2000553,biological_process,positive regulation of T-helper 2 cell cytokine production;GO:0070091,biological_process,glucagon secretion;GO:0031018,biological_process,endocrine pancreas development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0042832,biological_process,defense response to protozoan;GO:0032496,biological_process,response to lipopolysaccharide;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045188,biological_process,regulation of circadian sleep/wake cycle, non-REM sleep K05405,ko05142,Chagas disease (American trypanosomiasis);K05405,ko05143,African trypanosomiasis;K05405,ko04621,NOD-like receptor signaling pathway;K05405,ko05144,Malaria;K05405,ko05202,Transcriptional misregulation in cancer;K05405,ko05168,Herpes simplex infection;K05405,ko05410,Hypertrophic cardiomyopathy (HCM);K05405,ko05133,Pertussis;K05405,ko05132,Salmonella infection;K05405,ko05164,Influenza A;K05405,ko04931,Insulin resistance;K05405,ko05166,HTLV-I infection;K05405,ko05321,Inflammatory bowel disease (IBD);K05405,ko04932,Non-alcoholic fatty liver disease (NAFLD);K05405,ko04060,Cytokine-cytokine receptor interaction;K05405,ko04630,Jak-STAT signaling pathway;K05405,ko04151,PI3K-Akt signaling pathway;K05405,ko05200,Pathways in cancer;K05405,ko04068,FoxO signaling pathway;K05405,ko05323,Rheumatoid arthritis;K05405,ko05332,Graft-versus-host disease;K05405,ko05162,Measles;K05405,ko05020,Prion diseases;K05405,ko05134,Legionellosis;K05405,ko04672,Intestinal immune network for IgA production;K05405,ko04933,AGE-RAGE signaling pathway in diabetic complications;K05405,ko04623,Cytosolic DNA-sensing pathway;K05405,ko05152,Tuberculosis;K05405,ko04668,TNF signaling pathway;K05405,ko04620,Toll-like receptor signaling pathway;K05405,ko04066,HIF-1 signaling pathway;K05405,ko05161,Hepatitis B;K05405,ko04640,Hematopoietic cell lineage;K05405,ko05146,Amoebiasis;K05405,ko01521,EGFR tyrosine kinase inhibitor resistance Gm42846 0.609250825641975 1.04184676706359 0.952418872963576 2.26611246009685 1.39420243758941 2.4224355500558 -1.13437299315554 -0.238323460213685 10.9111568575288 0.007218236034382 0.0377319386297634 - - - - - - - Stap1 54.2768277622058 55.654761408368 69.2808575733825 24.2751240280251 24.2140323593566 26.384304750045 1.28229582567212 8.04778934733766 142.169592588354 4.96160586495987e-07 2.19427352912247e-05 Q5BK11,Signal transducing adaptor family member 1 NP_001020286.1,signal-transducing adaptor protein 1 PF00169,PH domain IPR011993,PH-like domain superfamily;IPR035877,STAP1, SH2 domain;IPR001849,Pleckstrin homology domain;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain ENOG410IGPX,-;ENOG4111PK4,- GO:0010760,biological_process,negative regulation of macrophage chemotaxis;GO:0019901,molecular_function,protein kinase binding;GO:1903997,biological_process,positive regulation of non-membrane spanning protein tyrosine kinase activity;GO:1904140,biological_process,negative regulation of microglial cell migration;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0005634,cellular_component,nucleus;GO:1904151,biological_process,positive regulation of microglial cell mediated cytotoxicity;GO:0005737,cellular_component,cytoplasm;GO:2000251,biological_process,positive regulation of actin cytoskeleton reorganization;GO:0060100,biological_process,positive regulation of phagocytosis, engulfment;GO:0005739,cellular_component,mitochondrion;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005068,molecular_function,transmembrane receptor protein tyrosine kinase adaptor activity;GO:0010628,biological_process,positive regulation of gene expression;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:1903980,biological_process,positive regulation of microglial cell activation;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:1900028,biological_process,negative regulation of ruffle assembly;GO:0050861,biological_process,positive regulation of B cell receptor signaling pathway;GO:0005654,cellular_component,nucleoplasm;GO:1902227,biological_process,negative regulation of macrophage colony-stimulating factor signaling pathway;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0042326,biological_process,negative regulation of phosphorylation;GO:0005070,molecular_function,SH3/SH2 adaptor activity;GO:0005157,molecular_function,macrophage colony-stimulating factor receptor binding - Cxcl2 135.044275416858 117.326069007 129.540122284743 15.6521631062456 17.3495054720709 15.157080025017 3.00474822904044 7.22035907552618 1730.20869267671 2.94390348678628e-13 2.39608137295246e-09 Q3U1J5,C-X-C motif chemokine NP_033166.1,C-X-C motif chemokine 2 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR018048,CXC chemokine, conserved site;IPR033899,CXC Chemokine domain;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain;IPR001089,CXC chemokine ENOG410ZT1C,-;ENOG410J3WE,- GO:0042060,biological_process,wound healing;GO:0006955,biological_process,immune response;GO:0006952,biological_process,defense response;GO:0071347,biological_process,cellular response to interleukin-1;GO:0005125,molecular_function,cytokine activity;GO:0009408,biological_process,response to heat;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005623,cellular_component,cell;GO:0051384,biological_process,response to glucocorticoid;GO:0030595,biological_process,leukocyte chemotaxis;GO:0030593,biological_process,neutrophil chemotaxis;GO:0008009,molecular_function,chemokine activity;GO:0070997,biological_process,neuron death;GO:0006935,biological_process,chemotaxis;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0001975,biological_process,response to amphetamine;GO:0010332,biological_process,response to gamma radiation;GO:0005615,cellular_component,extracellular space;GO:0032355,biological_process,response to estradiol;GO:0005576,cellular_component,extracellular region;GO:0007204,biological_process,positive regulation of cytosolic calcium ion concentration K05505,ko05134,Legionellosis;K05505,ko04668,TNF signaling pathway;K05505,ko05132,Salmonella infection;K05505,ko04062,Chemokine signaling pathway;K05505,ko04060,Cytokine-cytokine receptor interaction Cxcl10 1.02901706945463 0.951170938313829 0.869526288993389 0.108888642094959 0.339429273141957 0.192313209163439 2.09597246392083 0.510556612919803 50.2523086467723 2.24404483297795e-05 0.000425995546825426 Q548V9,C-X-C motif chemokine NP_067249.1,C-X-C motif chemokine 10 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR018048,CXC chemokine, conserved site;IPR033899,CXC Chemokine domain;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain;IPR001089,CXC chemokine ENOG410J1VC,-;ENOG410ZTJK,- GO:0048248,molecular_function,CXCR3 chemokine receptor binding;GO:0006935,biological_process,chemotaxis;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0051281,biological_process,positive regulation of release of sequestered calcium ion into cytosol;GO:0010818,biological_process,T cell chemotaxis;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0042118,biological_process,endothelial cell activation;GO:0006955,biological_process,immune response;GO:0030816,biological_process,positive regulation of cAMP metabolic process;GO:0008201,molecular_function,heparin binding;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0042127,biological_process,regulation of cell proliferation;GO:0005623,cellular_component,cell;GO:1901509,biological_process,regulation of endothelial tube morphogenesis;GO:0008009,molecular_function,chemokine activity;GO:0043950,biological_process,positive regulation of cAMP-mediated signaling;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:2000406,biological_process,positive regulation of T cell migration;GO:0010819,biological_process,regulation of T cell chemotaxis;GO:0005125,molecular_function,cytokine activity;GO:0006952,biological_process,defense response;GO:0090026,biological_process,positive regulation of monocyte chemotaxis;GO:0070098,biological_process,chemokine-mediated signaling pathway K12671,ko04668,TNF signaling pathway;K12671,ko04622,RIG-I-like receptor signaling pathway;K12671,ko05164,Influenza A;K12671,ko04062,Chemokine signaling pathway;K12671,ko04623,Cytosolic DNA-sensing pathway;K12671,ko04060,Cytokine-cytokine receptor interaction;K12671,ko04620,Toll-like receptor signaling pathway Agpat9 3.16552950401231 2.54858765596176 2.90451796533768 1.45295755467029 1.3505689175552 1.4685711011003 1.02535737467889 2.93341420356953 81.1435539036633 2.39527336921147e-06 7.36090062744674e-05 G3IK30,Glycerol-3-phosphate acyltransferase 3 XP_007624246.1,-;XP_007653098.1,glycerol-3-phosphate acyltransferase 3;XP_007624245.1,-;XP_007653099.1,-;XP_007624247.1,-;XP_016819200.1,- PF01553,Acyltransferase IPR002123,Phospholipid/glycerol acyltransferase - GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0008152,biological_process,metabolic process;GO:0016021,cellular_component,integral component of membrane;GO:0016740,molecular_function,transferase activity K13506,ko00561,Glycerolipid metabolism;K13506,ko00564,Glycerophospholipid metabolism Gm42987 1.11936228289012 1.04443291152084 1.18045902297244 0.44347795467696 0.386263290936119 0.483770015306241 1.36559813808323 0.952188995111039 50.3056395402051 2.2333280501029e-05 0.00042519155868876 F6ZBU4,Proline dehydrogenase - PF01619,Proline dehydrogenase IPR002872,Proline dehydrogenase domain;IPR029041,FAD-linked oxidoreductase-like;IPR015659,Proline oxidase family COG0506,Proline dehydrogenase;KOG0186,Proline oxidase GO:0016645,molecular_function,oxidoreductase activity, acting on the CH-NH group of donors;GO:0006562,biological_process,proline catabolic process;GO:0004657,molecular_function,proline dehydrogenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0006560,biological_process,proline metabolic process;GO:0055114,biological_process,oxidation-reduction process - Gbp9 1.31969405596046 1.19048061861838 1.07252221302348 0.319972211189924 0.507946425809043 0.366279894313315 1.57432260617402 2.0825007587646 91.333786004809 1.35131229364344e-06 4.68888260675368e-05 Q8BTS3,Guanylate-binding protein 9 NP_766365.1,guanylate binding protein family, member 9;XP_006534987.2,- PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0003674,molecular_function,molecular_function;GO:0005525,molecular_function,GTP binding;GO:0042832,biological_process,defense response to protozoan;GO:0044406,biological_process,adhesion of symbiont to host;GO:0020005,cellular_component,symbiont-containing vacuole membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding - Gm43302 2.048948693159 2.26752751703945 2.57455100137842 0.682739365191225 0.908938040827819 0.72851456287969 1.58048756651878 2.75745316247178 116.496243872867 4.08024406853769e-07 1.93508045686428e-05 L7N1X8,Predicted gene 43302 - PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0005525,molecular_function,GTP binding;GO:0006955,biological_process,immune response;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0042742,biological_process,defense response to bacterium - Gbp10 0.80855906114117 0.74894785453986 0.730305294103636 0.300744075520212 0.23437096145104 0.307512446255919 1.46383405876139 1.09079657899486 63.0541657194668 7.91649494047838e-06 0.000185476033596917 Q000W5,Guanylate-binding protein 10 NP_001034735.2,guanylate-binding protein 10 PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0003674,molecular_function,molecular_function;GO:0005525,molecular_function,GTP binding;GO:0042832,biological_process,defense response to protozoan;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding - Gbp6 1.38852704125484 1.59645431295006 1.8362669996148 0.504519813482305 0.690060738452607 0.518266979783667 1.50337810531884 2.72914130065535 88.7426842130836 1.5542031784356e-06 5.22105606951919e-05 A0A0G2JDV3,Guanylate-binding protein 6 NP_919317.2,guanylate binding protein 6;XP_006534750.1,- PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal ENOG410XR6Z,-;KOG2037,Guanylate-binding protein GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0035458,biological_process,cellular response to interferon-beta;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0003674,molecular_function,molecular_function;GO:0005525,molecular_function,GTP binding;GO:0042832,biological_process,defense response to protozoan;GO:0044406,biological_process,adhesion of symbiont to host;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0020005,cellular_component,symbiont-containing vacuole membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding - Oasl2 7.78219956413368 8.27544084870764 7.96192691761947 1.30803036522229 1.46157211923007 1.4608442047812 2.52184876876846 4.92015481367806 1169.22174886843 2.40124844504361e-12 6.47295630105914e-09 Q8K234,Oasl2 protein - PF10421,2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus;PF00240,Ubiquitin family IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal;IPR000626,Ubiquitin domain;IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily;IPR029071,Ubiquitin-like domain superfamily COG5272,Ubiquitin;KOG0001,Ubiquitin and ubiquitin-like proteins GO:0003723,molecular_function,RNA binding;GO:0051607,biological_process,defense response to virus;GO:0016740,molecular_function,transferase activity;GO:0006955,biological_process,immune response;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005524,molecular_function,ATP binding - Gm13822 9.59376357927092 9.41526358231215 8.80360463692472 3.72078154765522 4.14231244462981 4.38096160296596 1.1943885733047 1.27694519622035 54.2986083360368 1.57879176388139e-05 0.000316821667873475 - - - - - - - Oasl1 18.9477941208436 19.8831075814972 19.5425218455595 8.25069449015 9.12261723810422 9.02961397434278 1.16320821076128 5.21221711282005 319.671356502615 2.32267186434038e-09 4.22743339690135e-07 G3HI67,59 kDa 2'-5'-oligoadenylate synthetase-like protein - PF10421,2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus;PF00240,Ubiquitin family IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal;IPR000626,Ubiquitin domain;IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily;IPR029071,Ubiquitin-like domain superfamily - GO:0003723,molecular_function,RNA binding;GO:0051607,biological_process,defense response to virus;GO:0016740,molecular_function,transferase activity;GO:0006955,biological_process,immune response;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005524,molecular_function,ATP binding - Gm43068 0.836391785461049 0.981556603271746 0.598202514606432 0.288944095048525 0.150116795584385 0.297685136415205 1.76059078614637 -0.35931628866765 23.9564295800983 0.000503744437968626 0.00472898716903972 - - - - - - - Oas3 23.6294860184296 22.5559309230579 20.4370727694929 7.74434075696982 7.48147685748574 8.07945362008501 1.53335282130643 6.73234003474205 713.508432654727 3.34722894449637e-11 2.18462475777463e-08 A0A1U8CHX6,2'-5'-oligoadenylate synthase 3 isoform X1 XP_012975254.1,2'-5'-oligoadenylate synthase 3 isoform X1 - IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal;IPR002934,Polymerase, nucleotidyl transferase domain;IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily - GO:0006955,biological_process,immune response;GO:0051607,biological_process,defense response to virus;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0003723,molecular_function,RNA binding;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005524,molecular_function,ATP binding - Oas1b 4.71618862018035 4.3908890018848 4.01399292745325 1.81573997212262 1.99061125811377 2.20132009976915 1.13863506453205 2.69358211182987 98.7236547575354 9.24018044106391e-07 3.52609106767624e-05 A8YPC7,Putative oligoadenylate synthetase 1b - PF10421,2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily;IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal - GO:0051607,biological_process,defense response to virus;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0006955,biological_process,immune response;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005524,molecular_function,ATP binding - Oas1g 50.6133300856866 51.6438396451929 44.6539734402183 25.9364369420801 23.9690012002622 23.3896009537105 1.02339584100748 6.42826176035977 305.55867423248 2.94095984874743e-09 5.1023792008775e-07 Q8K469,2'-5' oligoadenylate synthetase 1G NP_035982.2,2'-5' oligoadenylate synthetase 1G PF10421,2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus;PF01909,Nucleotidyltransferase domain IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal;IPR002934,Polymerase, nucleotidyl transferase domain;IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily COG5272,Ubiquitin;KOG0001,Ubiquitin and ubiquitin-like proteins GO:0051607,biological_process,defense response to virus;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0005524,molecular_function,ATP binding;GO:0003723,molecular_function,RNA binding;GO:0006955,biological_process,immune response;GO:0008270,molecular_function,zinc ion binding;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0001730,molecular_function,2'-5'-oligoadenylate synthetase activity K14216,ko05160,Hepatitis C;K14216,ko05162,Measles;K14216,ko05168,Herpes simplex infection;K14216,ko05164,Influenza A Oas1a 54.2912622214196 55.4685298527063 51.1329636808847 27.3511516843754 26.9920550437072 24.6700098875317 1.04628043064633 6.24082452980231 398.958193229474 7.26264357096437e-10 1.63232304533493e-07 Q8K469,2'-5' oligoadenylate synthetase 1G NP_035982.2,2'-5' oligoadenylate synthetase 1G PF10421,2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus;PF01909,Nucleotidyltransferase domain IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal;IPR002934,Polymerase, nucleotidyl transferase domain;IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily COG5272,Ubiquitin;KOG0001,Ubiquitin and ubiquitin-like proteins GO:0051607,biological_process,defense response to virus;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0005524,molecular_function,ATP binding;GO:0003723,molecular_function,RNA binding;GO:0006955,biological_process,immune response;GO:0008270,molecular_function,zinc ion binding;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0001730,molecular_function,2'-5'-oligoadenylate synthetase activity K14216,ko05160,Hepatitis C;K14216,ko05162,Measles;K14216,ko05168,Herpes simplex infection;K14216,ko05164,Influenza A Trafd1 17.4517902574663 17.2992005749874 17.9816890806698 8.03542836239049 7.13531632422413 7.36136039043688 1.24960837514391 5.82161388968318 411.298243589239 6.18660841039994e-10 1.46599248672648e-07 G3V959,FLN29 gene product, isoform CRA_b XP_006249438.1,-;NP_446212.2,TRAF-type zinc finger domain-containing protein 1 - IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001293,Zinc finger, TRAF-type ENOG410IGBJ,-;ENOG4111IF3,- GO:0008270,molecular_function,zinc ion binding;GO:0045824,biological_process,negative regulation of innate immune response;GO:0046872,molecular_function,metal ion binding - Gm42917 3.2395337004825 2.74102250192431 1.40673362271057 1.38727415462145 0.823701210253974 0.58336388339987 1.43819529600215 0.742748946255962 17.2298787763876 0.0017420906269754 0.0127753312644862 - - - - - - - Hcar2 0.389415450006187 0.554931853130244 0.732764871519011 0.0952916665794748 0.123768575634017 0.112199312703643 2.32689946197391 -0.391629213848172 34.8357199037699 0.000111240095549681 0.00144654340569633 Q0VBA6,G protein-coupled receptor 109A NP_109626.1,hydroxycarboxylic acid receptor 2 PF00001,7 transmembrane receptor (rhodopsin family) IPR028017,Hydroxycarboxylic acid receptor 2/3;IPR017452,GPCR, rhodopsin-like, 7TM;IPR000276,G protein-coupled receptor, rhodopsin-like ENOG4110VUM,-;ENOG410IKI5,- GO:0070165,biological_process,positive regulation of adiponectin secretion;GO:0070553,molecular_function,nicotinic acid receptor activity;GO:0005525,molecular_function,GTP binding;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0050995,biological_process,negative regulation of lipid catabolic process;GO:0004871,molecular_function,signal transducer activity;GO:0035590,biological_process,purinergic nucleotide receptor signaling pathway;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0001614,molecular_function,purinergic nucleotide receptor activity;GO:0016021,cellular_component,integral component of membrane K08402,ko04024,cAMP signaling pathway Por 112.256032827977 115.909360948749 106.068391522684 47.7048425535481 50.3172664199661 49.5316994449664 1.19859698703579 8.33886869780723 502.528112550635 2.14917618885754e-10 6.69468382829123e-08 A0A1U8C9X6,NADPH--cytochrome P450 reductase XP_012976241.1,NADPH--cytochrome P450 reductase isoform X1 - IPR001709,Flavoprotein pyridine nucleotide cytochrome reductase;IPR017938,Riboflavin synthase-like beta-barrel;IPR017927,Ferredoxin reductase-type FAD-binding domain;IPR003097,FAD-binding, type 1;IPR008254,Flavodoxin/nitric oxide synthase;IPR023173,NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily;IPR029039,Flavoprotein-like superfamily;IPR001433,Oxidoreductase FAD/NAD(P)-binding;IPR023208,NADPH-cytochrome P450 reductase;IPR001094,Flavodoxin-like - GO:0010181,molecular_function,FMN binding;GO:0005737,cellular_component,cytoplasm;GO:0003958,molecular_function,NADPH-hemoprotein reductase activity;GO:0050661,molecular_function,NADP binding;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane - Serpine1 2.81160768019173 2.3832647988053 2.66635784696774 0.601022602935903 0.862803641287703 0.684383965582015 1.86547351726685 2.72115392960513 180.342253360757 4.49740143068458e-08 3.84515120616185e-06 G5E899,Plasminogen activator inhibitor 1 NP_032897.2,plasminogen activator inhibitor 1 precursor PF00079,Serpin (serine protease inhibitor) IPR023795,Serpin, conserved site;IPR023796,Serpin domain;IPR036186,Serpin superfamily;IPR000215,Serpin family KOG2392,Serpin;COG4826,Serine protease inhibitor GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0010757,biological_process,negative regulation of plasminogen activation;GO:0010469,biological_process,regulation of signaling receptor activity;GO:2000098,biological_process,negative regulation of smooth muscle cell-matrix adhesion;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0005102,molecular_function,signaling receptor binding;GO:0032757,biological_process,positive regulation of interleukin-8 production;GO:2000352,biological_process,negative regulation of endothelial cell apoptotic process;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0090399,biological_process,replicative senescence;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0031012,cellular_component,extracellular matrix;GO:0002020,molecular_function,protease binding;GO:0030336,biological_process,negative regulation of cell migration;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0035491,biological_process,positive regulation of leukotriene production involved in inflammatory response;GO:0048260,biological_process,positive regulation of receptor-mediated endocytosis;GO:1901331,biological_process,positive regulation of odontoblast differentiation;GO:0097187,biological_process,dentinogenesis;GO:0090026,biological_process,positive regulation of monocyte chemotaxis;GO:0001525,biological_process,angiogenesis;GO:0051918,biological_process,negative regulation of fibrinolysis;GO:0050829,biological_process,defense response to Gram-negative bacterium;GO:0030194,biological_process,positive regulation of blood coagulation;GO:0001300,biological_process,chronological cell aging;GO:0050729,biological_process,positive regulation of inflammatory response;GO:0061044,biological_process,negative regulation of vascular wound healing;GO:0070062,cellular_component,extracellular exosome;GO:0014912,biological_process,negative regulation of smooth muscle cell migration;GO:1902042,biological_process,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0033629,biological_process,negative regulation of cell adhesion mediated by integrin K03982,ko04115,p53 signaling pathway;K03982,ko05142,Chagas disease (American trypanosomiasis);K03982,ko04933,AGE-RAGE signaling pathway in diabetic complications;K03982,ko04390,Hippo signaling pathway;K03982,ko04066,HIF-1 signaling pathway;K03982,ko04610,Complement and coagulation cascades Hilpda 6.92745254294777 6.23061519293484 5.62183300898294 2.16760463688035 2.98862397410372 3.04301218452357 1.19509715116589 2.34368995088708 68.6198899652675 5.32334955526076e-06 0.00013801632391904 A0A0G2JX33,Hypoxia-inducible lipid droplet-associated - PF15220,Hypoxia-inducible lipid droplet-associated IPR026190,Hypoxia-inducible lipid droplet-associated protein - GO:0009986,cellular_component,cell surface;GO:0005811,cellular_component,lipid droplet;GO:0005654,cellular_component,nucleoplasm;GO:0010884,biological_process,positive regulation of lipid storage;GO:0005102,molecular_function,signaling receptor binding;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0001819,biological_process,positive regulation of cytokine production;GO:0016020,cellular_component,membrane;GO:0035425,biological_process,autocrine signaling;GO:0071456,biological_process,cellular response to hypoxia;GO:0030141,cellular_component,secretory granule;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space - Tbxas1 0.15840253487441 0.15702931992396 0.191400748020733 0.101117724047936 0.0420274204484104 0.10120022679257 1.10382256014628 0.314805759710731 12.7266399089096 0.00454977472551111 0.0266834456088384 Q8K320,Thromboxane A synthase 1, platelet - PF00067,Cytochrome P450 IPR036396,Cytochrome P450 superfamily;IPR002401,Cytochrome P450, E-class, group I;IPR001128,Cytochrome P450;IPR017972,Cytochrome P450, conserved site KOG0158,Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies;COG2124,Cytochrome P450 GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0005506,molecular_function,iron ion binding;GO:0046872,molecular_function,metal ion binding;GO:0004497,molecular_function,monooxygenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding;GO:0016021,cellular_component,integral component of membrane - Gm45193 9.36236371857658 9.5174805556055 7.71044717602528 3.95001968424369 4.00174428177511 4.39507552565593 1.12560397532564 3.34995269345639 118.846745116009 3.69422732687129e-07 1.81480572552322e-05 Q9CRZ4,Uncharacterized protein - PF00415,Regulator of chromosome condensation (RCC1) repeat IPR000408,Regulator of chromosome condensation, RCC1;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II KOG0941,E3 ubiquitin protein ligase;COG5021,Ubiquitin-protein ligase;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - Herc6 3.70717194164844 3.95734334494767 3.81669096544862 1.47125055169824 1.56301116435623 1.72452710292019 1.29007926399701 4.66364189249664 268.834742957557 5.73272384585849e-09 7.85727130313365e-07 F1LPM8,HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6 XP_008761185.1,-;XP_008773968.1,probable E3 ubiquitin-protein ligase HERC6 isoform X2 PF00632,HECT-domain (ubiquitin-transferase);PF00415,Regulator of chromosome condensation (RCC1) repeat IPR000408,Regulator of chromosome condensation, RCC1;IPR000569,HECT domain;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;IPR035983,HECT, E3 ligase catalytic domain KOG0941,E3 ubiquitin protein ligase;COG5021,Ubiquitin-protein ligase;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus - Gm44081 1.46106496600299 1.04103662183259 1.3534979801715 2.86023198286759 2.82338641897319 3.03095188438925 -1.17350836819186 0.533157903325829 28.7355119326637 0.00024608102421965 0.00271998912738268 A0A1A6HM80,Uncharacterized protein - - - - - - Tuba8 0.608873913951344 0.670471133495482 0.721083076599319 0.108359355721542 0.190000897813776 0.215300713838079 1.94340413100059 0.0888396108026872 44.9644101387737 3.68928325299318e-05 0.0006211955315175 G3HQ80,Tubulin alpha chain XP_003505766.1,tubulin alpha-8 chain isoform X1;XP_007627992.1,- PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain IPR017975,Tubulin, conserved site;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR002452,Alpha tubulin;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal - GO:0005874,cellular_component,microtubule;GO:0005856,cellular_component,cytoskeleton;GO:0005737,cellular_component,cytoplasm;GO:0007010,biological_process,cytoskeleton organization;GO:0007017,biological_process,microtubule-based process;GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0000166,molecular_function,nucleotide binding;GO:0005200,molecular_function,structural constituent of cytoskeleton K07374,ko04145,Phagosome;K07374,ko04210,Apoptosis;K07374,ko05130,Pathogenic Escherichia coli infection;K07374,ko04540,Gap junction Usp18 18.7668470811225 19.6737264956076 17.526858914068 3.93314361448162 3.92129013426283 4.26880180770314 2.22652569925615 4.99553509373724 1016.44215967483 5.0751918838332e-12 9.39954902122454e-09 Q4FK24,Usp18 protein - PF00443,Ubiquitin carboxyl-terminal hydrolase IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase KOG1863,Ubiquitin carboxyl-terminal hydrolase;COG5077,Ubiquitin carboxyl-terminal hydrolase GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination - Gm44148 89.1896936525246 103.514839570784 94.1561833631129 21.9221092450608 19.2005794769961 24.4983293616128 2.15590847364973 4.23019819509177 419.793778069632 5.55498980477597e-10 1.38430345935017e-07 Q4FK24,Usp18 protein - PF00443,Ubiquitin carboxyl-terminal hydrolase IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase KOG1863,Ubiquitin carboxyl-terminal hydrolase;COG5077,Ubiquitin carboxyl-terminal hydrolase GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination - C3ar1 14.6211706853368 12.8020501212601 11.5989353476735 5.81002477207446 6.34776105723249 6.1744154876512 1.10309670805463 5.36826282411336 226.913522189839 1.38067931765155e-08 1.53850331119774e-06 Q5U7A4,Complement component 3A receptor 1 NP_033909.1,C3a anaphylatoxin chemotactic receptor PF00001,7 transmembrane receptor (rhodopsin family) IPR001644,C3a anaphylatoxin chemotactic receptor;IPR017452,GPCR, rhodopsin-like, 7TM;IPR002234,Anaphylatoxin chemotactic receptor family;IPR000826,Formyl peptide receptor-related;IPR000276,G protein-coupled receptor, rhodopsin-like ENOG410YBJQ,-;ENOG410IUVF,- GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0090023,biological_process,positive regulation of neutrophil chemotaxis;GO:0010759,biological_process,positive regulation of macrophage chemotaxis;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0016020,cellular_component,membrane;GO:0005623,cellular_component,cell;GO:0004871,molecular_function,signal transducer activity;GO:0004876,molecular_function,complement component C3a receptor activity;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0007165,biological_process,signal transduction;GO:0006935,biological_process,chemotaxis;GO:0004875,molecular_function,complement receptor activity;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0002430,biological_process,complement receptor mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0007204,biological_process,positive regulation of cytosolic calcium ion concentration K04009,ko04080,Neuroactive ligand-receptor interaction;K04009,ko04610,Complement and coagulation cascades;K04009,ko05150,Staphylococcus aureus infection Cd69 0.250177539833442 0.370224546353984 0.292484176176827 0.0376735630661927 0.0807376512739339 0.0748541274259597 2.23098224000833 0.406608386756037 54.8942188540001 1.50198667726653e-05 0.000303631702044471 Q3U6A8,CD69 antigen NP_001028294.1,early activation antigen CD69 PF00059,Lectin C-type domain IPR016187,C-type lectin fold;IPR033992,Natural killer cell receptor-like, C-type lectin-like domain;IPR016186,C-type lectin-like/link domain superfamily;IPR001304,C-type lectin-like KOG4297,C-type lectin;ENOG410XPJ1,- GO:0035690,biological_process,cellular response to drug;GO:0032991,cellular_component,protein-containing complex;GO:0009897,cellular_component,external side of plasma membrane;GO:0042803,molecular_function,protein homodimerization activity;GO:0030246,molecular_function,carbohydrate binding;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane - Klra2 5.11475377016819 5.33722326516709 5.47376012377509 1.74416886036404 1.71163201962154 1.71136464845652 1.64517991896982 2.76718931982817 230.361418363985 1.27714062470917e-08 1.43479421330032e-06 E9Q433,Killer cell lectin-like receptor 2 NP_001164322.1,killer cell lectin-like receptor 2 isoform 1 PF08391,Ly49-like protein, N-terminal region;PF00059,Lectin C-type domain IPR016187,C-type lectin fold;IPR013600,Ly49-like, N-terminal;IPR033992,Natural killer cell receptor-like, C-type lectin-like domain;IPR001304,C-type lectin-like;IPR016186,C-type lectin-like/link domain superfamily KOG4297,C-type lectin;ENOG410XPJ1,- GO:0030246,molecular_function,carbohydrate binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Apold1 0.807688619090488 0.82570810498704 1.14368587212241 0.41247640369697 0.415198984030459 0.576723969279872 1.00102460644442 1.38067950405554 20.7942138285226 0.0008584735802095 0.0072648991769042 E9Q0X2,Apolipoprotein L domain-containing 1 NP_001103384.1,apolipoprotein L domain-containing protein 1 PF05461,Apolipoprotein L IPR008405,Apolipoprotein L ENOG410IWGQ,-;ENOG410YM8A,- GO:0005829,cellular_component,cytosol;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0003674,molecular_function,molecular_function;GO:0045601,biological_process,regulation of endothelial cell differentiation;GO:0042118,biological_process,endothelial cell activation;GO:0001525,biological_process,angiogenesis;GO:0001666,biological_process,response to hypoxia;GO:0008289,molecular_function,lipid binding;GO:0016020,cellular_component,membrane;GO:0006869,biological_process,lipid transport;GO:0005576,cellular_component,extracellular region;GO:0042157,biological_process,lipoprotein metabolic process;GO:0005654,cellular_component,nucleoplasm - Gipr 2.50020301486597 1.90960359233994 2.15575261653751 0.845090943128714 0.878109963372416 0.808466615661808 1.37852816829233 2.43029216605839 105.900706968743 6.54313834907728e-07 2.73415409184309e-05 A0A1D5QDM0,Gastric inhibitory polypeptide receptor XP_014979775.1,- - IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR000832,GPCR, family 2, secretin-like;IPR001749,GPCR, family 2, gastric inhibitory polypeptide receptor;IPR017981,GPCR, family 2-like;IPR017983,GPCR, family 2, secretin-like, conserved site - GO:0038192,biological_process,gastric inhibitory peptide signaling pathway;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0016519,molecular_function,gastric inhibitory peptide receptor activity;GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0007165,biological_process,signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane K04580,ko04024,cAMP signaling pathway;K04580,ko04080,Neuroactive ligand-receptor interaction Gm44698 6.19785787835368 4.76473063565497 5.38270990356613 3.35257920700183 2.11502446174588 1.97371447216956 1.15969169251633 0.698040084600846 23.549404187106 0.00053795150357603 0.0049852355023753 - - - - - - - Zfp36 15.1794404267181 14.6480552927548 12.1641242826047 7.66745492414022 6.56729616221512 6.61490933513296 1.03156881351893 5.18911322872459 159.723433311835 8.34937179112515e-08 5.89878813243099e-06 Q3U3D2,Zinc finger protein 36 NP_035886.1,mRNA decay activator protein ZFP36 PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar) IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type KOG1677,CCCH-type Zn-finger protein;COG5063,CCCH-type Zn-finger protein GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0000289,biological_process,nuclear-transcribed mRNA poly(A) tail shortening;GO:0061158,biological_process,3'-UTR-mediated mRNA destabilization;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0035925,molecular_function,mRNA 3'-UTR AU-rich region binding;GO:1904246,biological_process,negative regulation of polynucleotide adenylyltransferase activity;GO:0035278,biological_process,miRNA mediated inhibition of translation;GO:0045085,biological_process,negative regulation of interleukin-2 biosynthetic process;GO:0060213,biological_process,positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding;GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0070063,molecular_function,RNA polymerase binding;GO:0005737,cellular_component,cytoplasm;GO:0000288,biological_process,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0030014,cellular_component,CCR4-NOT complex;GO:0071889,molecular_function,14-3-3 protein binding;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0000165,biological_process,MAPK cascade;GO:0061014,biological_process,positive regulation of mRNA catabolic process;GO:0017091,molecular_function,AU-rich element binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0050779,biological_process,RNA destabilization;GO:0045638,biological_process,negative regulation of myeloid cell differentiation;GO:0038066,biological_process,p38MAPK cascade;GO:0035556,biological_process,intracellular signal transduction;GO:0046872,molecular_function,metal ion binding;GO:1990904,cellular_component,ribonucleoprotein complex;GO:0009611,biological_process,response to wounding;GO:1900153,biological_process,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0030529,,;GO:0043488,biological_process,regulation of mRNA stability K15308,ko05166,HTLV-I infection Arhgap33 0.727721338514185 0.526878467189111 0.346586544725792 1.12590366172176 1.11020597903797 1.07541863722411 -1.04656995808876 2.15463994681817 31.6232352855365 0.000166521012459192 0.00200142419596618 A0A140LHW2,Rho GTPase-activating protein 33 NP_001276599.1,rho GTPase-activating protein 33 isoform b PF14604,Variant SH3 domain;PF00620,RhoGAP domain IPR035510,Rho GTPase-activating protein 33;IPR036871,PX domain superfamily;IPR000198,Rho GTPase-activating protein domain;IPR008936,Rho GTPase activation protein;IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily - GO:0019901,molecular_function,protein kinase binding;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0005096,molecular_function,GTPase activator activity;GO:0007165,biological_process,signal transduction - Gm12764 5.17695336900445 5.27987228440843 4.8487090831407 1.1923041588226 1.39375050811207 1.40385525781544 1.94492265883145 1.070708648563 112.338855137625 4.88689977074155e-07 2.19081033337641e-05 - - - - - - - 2310043P16Rik 0.823030205791226 0.988873024376856 0.770846045941203 0.126368060807961 0.209268073514666 0.12554123046008 2.4744554156072 1.06557649153162 111.989313348899 4.96297091805024e-07 2.19427352912247e-05 Q4YIL0,Uncharacterized protein XP_668908.1,- - - - - - Siglece 0.57583923358135 0.458566591271995 0.853119146709636 0.165776921307361 0.465086026774013 0.234228959997871 1.0640384103091 -0.0584822052621329 7.35111471848484 0.0205657144607463 0.0830505840892718 Q6PJ50,Sialic acid binding Ig-like lectin E - PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain ENOG410IJT6,-;ENOG410YKZU,- GO:0030246,molecular_function,carbohydrate binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Saa3 1.7063698872585 1.36993921276717 1.4402015753614 0.588107305251939 0.678304987415591 0.498567935958631 1.3523183013479 1.50375855821481 63.1108287089457 7.88338514785878e-06 0.000185016569925604 A0A1A6HJV6,Serum amyloid A protein - PF00277,Serum amyloid A protein IPR000096,Serum amyloid A protein - GO:0034364,cellular_component,high-density lipoprotein particle;GO:0006953,biological_process,acute-phase response;GO:0005576,cellular_component,extracellular region - Gm44829 0.156920726278722 0.139761258552742 0.255529439765778 0.422391080798048 0.314208604475208 0.491684585971103 -1.12392864785977 0.0680162118125185 12.4881865160282 0.00482306033573791 0.0278219128626363 A0A0G2JVW5,E3 ubiquitin-protein ligase HUWE1 - PF06012,omain of Unknown Function (DUF908);PF00627,UBA/TS-N domain;PF14377,omain of unknown function (DUF4414);PF02825,WWE domain;PF06025,omain of Unknown Function (DUF913) IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR009060,UBA-like superfamily;IPR010309,E3 ubiquitin ligase, domain of unknown function DUF908;IPR015940,Ubiquitin-associated domain;IPR010314,E3 ubiquitin ligase, domain of unknown function DUF913;IPR016024,Armadillo-type fold;IPR025527,Domain of unknown function DUF4414;IPR035983,HECT, E3 ligase catalytic domain;IPR000569,HECT domain - GO:0000209,biological_process,protein polyubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0006284,biological_process,base-excision repair;GO:1903955,biological_process,positive regulation of protein targeting to mitochondrion;GO:0016574,biological_process,histone ubiquitination;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0006513,biological_process,protein monoubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity - Isg20 1.98668177832457 2.03934969771542 1.93009903503084 0.725104688703315 0.359594291788294 0.698531204896877 1.78822065682178 1.32896531511447 65.4494848919178 6.64963238237321e-06 0.000163040897017544 Q4FK39,Interferon-stimulated protein, isoform CRA_b NP_001106999.1,-;NP_001278150.1,-;NP_065608.2,interferon-stimulated gene 20 kDa protein isoform b PF00929,xonuclease IPR036397,Ribonuclease H superfamily;IPR013520,Exonuclease, RNase T/DNA polymerase III;IPR012337,Ribonuclease H-like superfamily KOG2249,3'-5' exonuclease;COG0847,DNA polymerase III, epsilon subunit and related 3'-5' exonucleases GO:0003676,molecular_function,nucleic acid binding - Gm44851 1.16636307911121 1.35288171932106 1.08363369579668 0.371702155475301 0.372431383068492 0.445468687401755 1.62168443256729 0.972282849779021 67.2172650221445 5.86727041654582e-06 0.000147553776750783 - - - - - - - Trim34a 6.88650875372631 6.76617575361302 6.65231594319869 2.50704335761689 2.1196323581767 1.77529873158109 1.69149862443118 3.54590647112262 249.182790251442 8.50349914138862e-09 1.07268534587324e-06 E9PYZ4,Tripartite motif-containing protein 34A NP_109609.2,tripartite motif-containing protein 34A;XP_006508431.1,-;XP_006508430.1,-;XP_006508432.1,- PF13445,RING-type zinc-finger;PF00643,B-box zinc finger;PF00622,SPRY domain IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR000315,B-box-type zinc finger;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR003877,SPRY domain;IPR035826,TRIM34, PRY/SPRY domain ENOG4111G04,-;KOG2177,Predicted E3 ubiquitin ligase GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular - Trim34b 3.01305819133165 2.12273932287479 2.55797400367479 0.762161635939259 0.800548527587376 0.907146605278242 1.63471870306215 1.69570730099687 81.7787828097786 2.30707568416148e-06 7.13787343727252e-05 K7N6K2,Tripartite motif-containing 34B NP_001230845.1,tripartite motif-containing 34B PF13445,RING-type zinc-finger;PF00643,B-box zinc finger;PF00622,SPRY domain IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR000315,B-box-type zinc finger;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR003877,SPRY domain;IPR035826,TRIM34, PRY/SPRY domain ENOG4111G04,-;KOG2177,Predicted E3 ubiquitin ligase GO:0003674,molecular_function,molecular_function;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular;GO:0005575,cellular_component,cellular_component;GO:0008270,molecular_function,zinc ion binding;GO:0008150,biological_process,biological_process - Trim12c 9.5788565104463 8.66264944261403 8.6826307343986 4.58962714969235 4.6114053316304 4.41484795608287 1.00043564427787 4.66786218030349 249.029024250478 8.53076774406710e-09 1.07268534587324e-06 D3Z3L3,Tripartite motif-containing 12C NP_783608.3,tripartite motif-containing 12C;NP_001139479.1,- PF15227,zinc finger of C3HC4-type, RING;PF00643,B-box zinc finger;PF00622,SPRY domain IPR032917,Tripartite motif-containing protein 5;IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR003877,SPRY domain ENOG410ITFH,-;ENOG410ZW0W,- GO:0051607,biological_process,defense response to virus;GO:0019901,molecular_function,protein kinase binding;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0045087,biological_process,innate immune response;GO:0042803,molecular_function,protein homodimerization activity;GO:0006914,biological_process,autophagy;GO:0046872,molecular_function,metal ion binding;GO:1990462,cellular_component,omegasome;GO:0042802,molecular_function,identical protein binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0000932,cellular_component,P-body;GO:0005622,cellular_component,intracellular;GO:0008329,molecular_function,signaling pattern recognition receptor activity;GO:0002221,biological_process,pattern recognition receptor signaling pathway;GO:0030674,molecular_function,protein binding, bridging;GO:0008270,molecular_function,zinc ion binding - Gm27995 15.6577462189988 14.7265040524438 18.4938580265683 7.35651665993545 8.59944063505149 6.49634020554096 1.12197958530707 0.37749891331171 22.3605364393537 0.000654870661348352 0.00582456669983161 - - - - - - - Trim30c 0.912456073368226 0.780170801676407 1.23622045632141 0.250075838284519 0.389770036553745 0.599409789749797 1.22524910310612 0.382072698151465 14.5148871940667 0.00299585893887402 0.0193776510694702 D3YVI9,Tripartite motif-containing 30C - PF15227,zinc finger of C3HC4-type, RING;PF00643,B-box zinc finger;PF00622,SPRY domain IPR032917,Tripartite motif-containing protein 5;IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR003877,SPRY domain ENOG410ITFH,-;ENOG410ZW0W,- GO:0051607,biological_process,defense response to virus;GO:0008150,biological_process,biological_process;GO:0016567,biological_process,protein ubiquitination;GO:0045087,biological_process,innate immune response;GO:0006914,biological_process,autophagy;GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005622,cellular_component,intracellular;GO:0005575,cellular_component,cellular_component;GO:0008270,molecular_function,zinc ion binding;GO:0003674,molecular_function,molecular_function - Trim30a 18.9066047752639 20.3535194550704 21.6463374672441 4.98069521693514 5.3689850717503 5.59666055978859 1.95343975567378 5.72926033387796 590.043732444978 9.18294447508389e-11 4.06004635404838e-08 E9PWL0,Tripartite motif-containing 30D NP_954597.2,tripartite motif-containing 79 isoform 1 PF00097,Zinc finger, C3HC4 type (RING finger);PF00643,B-box zinc finger;PF00622,SPRY domain IPR032917,Tripartite motif-containing protein 5;IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR000315,B-box-type zinc finger;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018957,Zinc finger, C3HC4 RING-type;IPR003877,SPRY domain ENOG410ITFH,-;ENOG410ZW0W,- GO:0051607,biological_process,defense response to virus;GO:0008150,biological_process,biological_process;GO:0016567,biological_process,protein ubiquitination;GO:0045087,biological_process,innate immune response;GO:0006914,biological_process,autophagy;GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005622,cellular_component,intracellular;GO:0005575,cellular_component,cellular_component;GO:0008270,molecular_function,zinc ion binding;GO:0003674,molecular_function,molecular_function - Gm4070 24.1272785942782 24.2831547668657 30.6833249389584 11.9105507827526 11.5998444505157 12.9693332764708 1.1395654438809 7.48868855089772 107.931815650808 1.6873846378037e-06 5.51964053597555e-05 L7N451,Interferon-induced very large GTPase 1 NP_001034249.2,-;XP_017167845.1,-;NP_083276.2,interferon-induced very large GTPase 1 - IPR029028,Alpha/beta knot methyltransferases;IPR030383,Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase ENOG410Y9GN,-;ENOG410IG57,- GO:0005525,molecular_function,GTP binding - Gm20663 30.390562281601 25.0431535478204 36.2624667187613 13.9680696074724 12.1956436573046 13.4769364320294 1.2290046351576 3.395019663234 67.6520097737674 6.32553101019755e-06 0.000157346148867092 L7N451,Interferon-induced very large GTPase 1 NP_001034249.2,-;XP_017167845.1,-;NP_083276.2,interferon-induced very large GTPase 1 - IPR029028,Alpha/beta knot methyltransferases;IPR030383,Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase ENOG410Y9GN,-;ENOG410IG57,- GO:0005525,molecular_function,GTP binding - Gvin1 30.6860527787774 31.339630046491 36.0852819841 14.6572092993161 14.9504742486119 15.2759582290205 1.15035616984214 7.75207624627571 213.427204283954 1.89418601090501e-08 1.92308988633067e-06 L7N451,Interferon-induced very large GTPase 1 NP_001034249.2,-;XP_017167845.1,-;NP_083276.2,interferon-induced very large GTPase 1 - IPR029028,Alpha/beta knot methyltransferases;IPR030383,Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase ENOG410Y9GN,-;ENOG410IG57,- GO:0005525,molecular_function,GTP binding - Adm 1.89556408827903 1.04742387555518 2.38539388854113 0.340789839095219 0.118035009746091 0.501570429705139 2.48774070573237 0.846005070448197 29.4641380004586 0.000344202835791064 0.00350233412572556 A0A1A6GKL9,Uncharacterized protein - PF00214,Calcitonin / CGRP / IAPP family IPR001710,Adrenomedullin;IPR021116,Calcitonin/adrenomedullin - GO:0005179,molecular_function,hormone activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005576,cellular_component,extracellular region - Sult1a1 0.290920301348351 0.50340948078974 0.288752223374344 0.732234571327351 0.729142279017121 0.862155302659716 -1.02528843506306 -0.0508391809490636 12.2778995229168 0.0050804372092947 0.0288827053976401 E9QNL5,Sulfotransferase - PF00685,Sulfotransferase domain IPR000863,Sulfotransferase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase KOG1584,Sulfotransferase;ENOG4111H56,- GO:0008146,molecular_function,sulfotransferase activity;GO:0016740,molecular_function,transferase activity - Irf7 36.1090185580088 38.0193595408897 33.0453252063712 9.15668122396627 8.79327218891359 9.63440284720057 1.97771175852132 6.41312596937612 1000.25350325099 5.52954943186131e-12 9.39954902122454e-09 Q542T3,Interferon regulatory factor 7 NP_058546.1,interferon regulatory factor 7 isoform 1 PF00605,Interferon regulatory factor transcription factor;PF10401,Interferon-regulatory factor 3 IPR019817,Interferon regulatory factor, conserved site;IPR017855,SMAD-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR019471,Interferon regulatory factor-3;IPR008984,SMAD/FHA domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily;IPR001346,Interferon regulatory factor DNA-binding domain ENOG410IWNR,-;ENOG4111G85,- GO:0000982,molecular_function,transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0005737,cellular_component,cytoplasm;GO:0002819,biological_process,regulation of adaptive immune response;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0051607,biological_process,defense response to virus;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0032727,biological_process,positive regulation of interferon-alpha production;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0000979,molecular_function,RNA polymerase II core promoter sequence-specific DNA binding;GO:0005829,cellular_component,cytosol;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm K09447,ko05168,Herpes simplex infection;K09447,ko05203,Viral carcinogenesis;K09447,ko04623,Cytosolic DNA-sensing pathway;K09447,ko05162,Measles;K09447,ko05161,Hepatitis B;K09447,ko04622,RIG-I-like receptor signaling pathway;K09447,ko05164,Influenza A;K09447,ko04620,Toll-like receptor signaling pathway;K09447,ko05160,Hepatitis C Retn 1.07095414290808 1.13048182028855 0.93010126796063 0.349422893917137 0.36307539096692 0.308565874234054 1.62755256890956 0.26884807743735 47.0507231440077 3.01548075009865e-05 0.000538153374490262 Q5BMX4,Resistin NP_001191888.1,-;NP_075360.1,resistin precursor PF06954,Resistin IPR036262,Resistin-like superfamily;IPR009714,Resistin ENOG410J40Z,-;ENOG410ZE8R,- GO:0005179,molecular_function,hormone activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005576,cellular_component,extracellular region - Kbtbd11 5.59879057739734 4.73957314708771 5.12918034924892 10.9432093605597 10.6500630909088 11.7875305677113 -1.09458693641877 5.85989238941114 245.263885522247 9.23198231618227e-09 1.13591120414884e-06 D4A5J1,Kelch repeat and BTB domain-containing 11 NP_001100796.1,kelch repeat and BTB domain-containing protein 11;XP_006253454.1,-;XP_006253455.1,-;XP_006253452.1,-;XP_006253453.1,- PF13964,Kelch motif;PF00651,BTB/POZ domain;PF01344,Kelch motif IPR015915,Kelch-type beta propeller;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily ENOG4110X8D,-;KOG1072,FOG: Kelch repeat GO:0016567,biological_process,protein ubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex - Gm37844 0.611481424222553 0.6644305494775 0.371741177004632 1.52624826969615 1.51591582262996 1.18922508034067 -1.32739148560097 2.03723538762562 50.9885194172468 2.10132839120816e-05 0.000405645168026746 D4A5J1,Kelch repeat and BTB domain-containing 11 NP_001100796.1,kelch repeat and BTB domain-containing protein 11;XP_006253454.1,-;XP_006253455.1,-;XP_006253452.1,-;XP_006253453.1,- PF13964,Kelch motif;PF00651,BTB/POZ domain;PF01344,Kelch motif IPR015915,Kelch-type beta propeller;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily ENOG4110X8D,-;KOG1072,FOG: Kelch repeat GO:0016567,biological_process,protein ubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex - Mfap3l 2.2626668515973 2.25184885187688 2.4424259066827 0.878721945143672 0.901408871598689 0.918501613576558 1.38483676557999 3.47912117544005 219.191996819214 1.65094349967313e-08 1.73898686816719e-06 A0A1U7QXL3,microfibrillar-associated protein 3-like isoform X1 XP_005075217.1,microfibrillar-associated protein 3-like isoform X1 - IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set - GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Ddx60 0.48321925226758 0.48819071122865 0.501093506016969 0.10589182202809 0.13203501665978 0.112212232937718 2.07430112560081 1.46382166055718 155.309143368708 9.62533638624352e-08 6.47840613551831e-06 E9PZQ1,DEAD - PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase IPR011545,DEAD/DEAH box helicase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR001650,Helicase, C-terminal KOG0949,Predicted helicase, DEAD-box superfamily;COG4581,Superfamily II RNA helicase;KOG0948,Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily GO:0051607,biological_process,defense response to virus;GO:0003727,molecular_function,single-stranded RNA binding;GO:0005515,molecular_function,protein binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:1900245,biological_process,positive regulation of MDA-5 signaling pathway;GO:0003690,molecular_function,double-stranded DNA binding;GO:0003723,molecular_function,RNA binding;GO:0009615,biological_process,response to virus;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005829,cellular_component,cytosol;GO:0005524,molecular_function,ATP binding;GO:1900246,biological_process,positive regulation of RIG-I signaling pathway - Lrrc25 5.2409053734408 4.87612146419827 4.51400000648481 1.65343562550416 2.11450822438641 1.31034985704203 1.52805032211938 2.2832108974751 98.677076146653 9.26158459334194e-07 3.52609106767624e-05 B9EHD0,Leucine rich repeat containing 25 NP_694714.1,leucine-rich repeat-containing protein 25 precursor PF13855,Leucine rich repeat IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily ENOG4111DR8,-;ENOG410J965,- GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Hmox1 122.686623714828 116.317540618095 114.969208446147 44.1839140721423 44.7188374923834 41.8310884166044 1.45622007576144 7.14939705866605 914.118968447701 8.94194418972431e-12 1.03801927023509e-08 Q3U5U6,Uncharacterized protein NP_034572.1,heme oxygenase 1 PF01126,Heme oxygenase IPR018207,Haem oxygenase conserved site;IPR002051,Haem oxygenase;IPR016084,Haem oxygenase-like, multi-helical;IPR016053,Haem oxygenase-like COG5398,Heme oxygenase;KOG4480,Heme oxygenase GO:0071243,biological_process,cellular response to arsenic-containing substance;GO:0090050,biological_process,positive regulation of cell migration involved in sprouting angiogenesis;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0034101,biological_process,erythrocyte homeostasis;GO:0048662,biological_process,negative regulation of smooth muscle cell proliferation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0051260,biological_process,protein homooligomerization;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0001666,biological_process,response to hypoxia;GO:1902042,biological_process,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0042167,biological_process,heme catabolic process;GO:1904036,biological_process,negative regulation of epithelial cell apoptotic process;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:0002246,biological_process,wound healing involved in inflammatory response;GO:0005634,cellular_component,nucleus;GO:0042542,biological_process,response to hydrogen peroxide;GO:0032764,biological_process,negative regulation of mast cell cytokine production;GO:0042168,biological_process,heme metabolic process;GO:0071276,biological_process,cellular response to cadmium ion;GO:0035556,biological_process,intracellular signal transduction;GO:0008217,biological_process,regulation of blood pressure;GO:0008219,biological_process,cell death;GO:0004630,molecular_function,phospholipase D activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0005829,cellular_component,cytosol;GO:0016021,cellular_component,integral component of membrane;GO:0043627,biological_process,response to estrogen;GO:1903589,biological_process,positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0055072,biological_process,iron ion homeostasis;GO:0004392,molecular_function,heme oxygenase (decyclizing) activity;GO:0035094,biological_process,response to nicotine;GO:0034395,biological_process,regulation of transcription from RNA polymerase II promoter in response to iron;GO:0051090,biological_process,regulation of DNA binding transcription factor activity;GO:0043392,biological_process,negative regulation of DNA binding;GO:0001525,biological_process,angiogenesis;GO:0031670,biological_process,cellular response to nutrient;GO:0006979,biological_process,response to oxidative stress;GO:0016020,cellular_component,membrane;GO:0010656,biological_process,negative regulation of muscle cell apoptotic process;GO:0020037,molecular_function,heme binding;GO:0071456,biological_process,cellular response to hypoxia;GO:0006788,biological_process,heme oxidation;GO:0019899,molecular_function,enzyme binding;GO:0097421,biological_process,liver regeneration;GO:0005901,cellular_component,caveola;GO:0072719,biological_process,cellular response to cisplatin;GO:0005730,cellular_component,nucleolus;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0043305,biological_process,negative regulation of mast cell degranulation;GO:0046872,molecular_function,metal ion binding;GO:0016239,biological_process,positive regulation of macroautophagy;GO:1904706,biological_process,negative regulation of vascular smooth muscle cell proliferation;GO:0043619,biological_process,regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0055114,biological_process,oxidation-reduction process;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0042803,molecular_function,protein homodimerization activity;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0034605,biological_process,cellular response to heat K00510,ko04978,Mineral absorption;K00510,ko00860,Porphyrin and chlorophyll metabolism Ccl22 0.754265624313058 0.748561300808485 0.561483355645337 0 0.0410964904900908 0.162990614475938 3.27713888582431 -0.0116231180716862 43.4870444988547 4.27575247563185e-05 0.000699325339272197 Q546S6,C-C motif chemokine NP_033163.1,C-C motif chemokine 22 precursor PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like IPR030598,C-C motif chemokine 22;IPR036048,Chemokine interleukin-8-like superfamily;IPR001811,Chemokine interleukin-8-like domain;IPR000827,CC chemokine, conserved site ENOG410J20K,-;ENOG41113E8,- GO:0060326,biological_process,cell chemotaxis;GO:0005125,molecular_function,cytokine activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0006955,biological_process,immune response;GO:0008009,molecular_function,chemokine activity;GO:0006954,biological_process,inflammatory response;GO:0006935,biological_process,chemotaxis;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space - Gm10722 0 2.26213579914652 2.17240584029446 0.0941694400913397 0.146773180321753 0.415792383867189 2.80575763766035 -0.537378710923023 8.10723813209304 0.0187894695811368 0.0775221162188625 F6VLK5,Predicted gene 10722 - - - ENOG410YF7P,-;ENOG410J9TA,- GO:0016021,cellular_component,integral component of membrane;GO:0005575,cellular_component,cellular_component;GO:0003674,molecular_function,molecular_function;GO:0016020,cellular_component,membrane;GO:0008150,biological_process,biological_process - Gm11168 0 1.22650107426337 1.06372457869517 0.0324018528009842 0.0505017655335418 0.171679180907531 3.22600848845405 -0.0715169129720788 9.18900500020725 0.0148521878290693 0.0646851243677228 J3QN50,Predicted gene 11168 - - - ENOG410YF7P,-;ENOG410J9TA,- GO:0003674,molecular_function,molecular_function;GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - Gm10719 0 0.917307491482193 1.54115483554736 0.136231789998805 0.106165933766068 0.330832140096993 2.17349914710453 0.0662196883230146 5.3289549175614 0.0474359500826505 0.154652029455948 E9Q7T3,Predicted gene 10719 - - - ENOG410YF7P,-;ENOG410J9TA,- GO:0016020,cellular_component,membrane;GO:0005575,cellular_component,cellular_component;GO:0003674,molecular_function,molecular_function;GO:0016021,cellular_component,integral component of membrane;GO:0008150,biological_process,biological_process - RP24-79I19.5 0.176973678654973 0.176535964391768 0.276656287484192 0.433062344585067 0.512980352472382 0.336534530757043 -1.01177941959634 0.304451265363099 13.2363217973785 0.00402507649118221 0.0243781256686449 A0A061I1L9,Junctional adhesion molecule C-like protein - PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain - GO:0007283,biological_process,spermatogenesis;GO:0030010,biological_process,establishment of cell polarity;GO:0030057,cellular_component,desmosome;GO:0090022,biological_process,regulation of neutrophil chemotaxis;GO:0044291,cellular_component,cell-cell contact zone;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005615,cellular_component,extracellular space;GO:0005794,cellular_component,Golgi apparatus;GO:0019226,biological_process,transmission of nerve impulse;GO:0007155,biological_process,cell adhesion;GO:0005923,cellular_component,bicellular tight junction;GO:0007160,biological_process,cell-matrix adhesion;GO:0042803,molecular_function,protein homodimerization activity;GO:0002523,biological_process,leukocyte migration involved in inflammatory response;GO:0043220,cellular_component,Schmidt-Lanterman incisure;GO:0016021,cellular_component,integral component of membrane;GO:0002250,biological_process,adaptive immune response;GO:0042552,biological_process,myelination;GO:0005911,cellular_component,cell-cell junction;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0001780,biological_process,neutrophil homeostasis;GO:0007286,biological_process,spermatid development;GO:0090138,biological_process,regulation of actin cytoskeleton organization by cell-cell adhesion;GO:0002318,biological_process,myeloid progenitor cell differentiation;GO:0005178,molecular_function,integrin binding;GO:0033010,cellular_component,paranodal junction;GO:0016477,biological_process,cell migration - Gm37842 8.90166324241357 10.5804884553163 13.0697418288461 3.94629372558679 4.50646984628433 4.69249133181204 1.32983920798137 3.60072700138091 72.5953090323139 5.74074622508878e-06 0.000145170973728906 - - - - - - - Cd109 0.190616040926941 0.174622577696963 0.252260638043557 0.479772825647964 0.456975106210466 0.384445253709549 -1.07875381782062 1.21992348928553 30.2255170988692 0.000200456602596334 0.0023068498700129 A6MDD3,CD109 antigen NP_694738.1,CD109 antigen precursor PF07678,A-macroglobulin complement component;PF01835,MG2 domain;PF07703,Alpha-2-macroglobulin family N-terminal region;PF10569,Alpha-macro-globulin thiol-ester bond-forming region;PF00207,Alpha-2-macroglobulin family;PF07677,A-macroglobulin receptor IPR001599,Alpha-2-macroglobulin;IPR008930,Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;IPR009048,Alpha-macroglobulin, receptor-binding;IPR036595,Alpha-macroglobulin, receptor-binding domain superfamily;IPR002890,Alpha-2-macroglobulin, N-terminal;IPR013783,Immunoglobulin-like fold;IPR019565,Alpha-2-macroglobulin, thiol-ester bond-forming;IPR014756,Immunoglobulin E-set;IPR011625,Alpha-2-macroglobulin, N-terminal 2;IPR019742,Alpha-2-macroglobulin, conserved site;IPR011626,Alpha-macroglobulin complement component KOG1366,Alpha-macroglobulin;ENOG410XRED,- GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0001942,biological_process,hair follicle development;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0072675,biological_process,osteoclast fusion;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0061045,biological_process,negative regulation of wound healing;GO:0045616,biological_process,regulation of keratinocyte differentiation;GO:0010839,biological_process,negative regulation of keratinocyte proliferation;GO:0050431,molecular_function,transforming growth factor beta binding;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space - Fam46a 2.88829546245602 2.93436151077659 3.20467880523509 1.35443494528007 1.29845237246769 1.62323071942765 1.09969437929018 3.67781105202958 101.196773809997 8.18347517422359e-07 3.24058519316218e-05 D3Z5S8,Family with sequence similarity 46, member A NP_001153850.1,protein FAM46A isoform 1 PF07984,Nucleotidyltransferase IPR012937,FAM46 family KOG3852,Uncharacterized conserved protein;ENOG410XTG4,- GO:0005575,cellular_component,cellular_component - Gm2396 0.166664113208103 0.148439194553356 0.132682270952337 0.061175157943803 0.0317826833538511 0.0900368694636456 1.32150074600426 0.0745449486935203 16.3813233665454 0.0020015489271919 0.0142239552387367 A0A0V1KIA3,Uncharacterized protein - - - - - - Bcl2a1a 11.7767663869392 10.9521120159145 11.2905116157316 3.44322106590386 4.43330272869294 3.63551802304388 1.56668312232009 2.66491452061963 170.746350704089 5.94547424078433e-08 4.65439684478014e-06 O55179,A1-d protein NP_031562.1,B cell leukemia/lymphoma 2 related protein A1d PF00452,Apoptosis regulator proteins, Bcl-2 family IPR020717,Apoptosis regulator, Bcl-2, BH1 motif, conserved site;IPR002475,Bcl2-like;IPR026298,Blc2 family;IPR013282,Bcl-2-related protein A1;IPR020726,Apoptosis regulator, Bcl-2, BH2 motif, conserved site;IPR036834,Blc2-like superfamily ENOG41123S0,-;KOG4728,Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel GO:0042981,biological_process,regulation of apoptotic process;GO:0030217,biological_process,T cell differentiation;GO:0008053,biological_process,mitochondrial fusion;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0015267,molecular_function,channel activity;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0042803,molecular_function,protein homodimerization activity;GO:0043027,molecular_function,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0055085,biological_process,transmembrane transport;GO:0046982,molecular_function,protein heterodimerization activity;GO:0001836,biological_process,release of cytochrome c from mitochondria;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0050852,biological_process,T cell receptor signaling pathway K02162,ko04210,Apoptosis;K02162,ko04064,NF-kappa B signaling pathway;K02162,ko05202,Transcriptional misregulation in cancer Cish 0.243928123056532 0.298941907431577 0.31353277814165 0.706732918984296 0.513546073132327 0.708434046405775 -1.1245165902566 1.62188104246417 35.0320558430018 0.000108634787863938 0.00142075229242666 F6XMN0,Cytokine inducible SH2 containing protein XP_001493470.2,cytokine-inducible SH2-containing protein isoform X2 PF07525,SOCS box;PF00017,SH2 domain IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR028425,Cytokine-inducible SH2-containing protein;IPR035887,CIS, SH2 domain ENOG4111V4J,-;KOG4566,Cytokine-inducible SH2 protein GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0004860,molecular_function,protein kinase inhibitor activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0007205,biological_process,protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0016567,biological_process,protein ubiquitination;GO:0005886,cellular_component,plasma membrane;GO:0046627,biological_process,negative regulation of insulin receptor signaling pathway K04701,ko04917,Prolactin signaling pathway;K04701,ko04630,Jak-STAT signaling pathway Gm17041 1.83055070618775 1.21113780402208 1.1355678513182 4.35145383503489 2.39372042729339 3.50359336067797 -1.26887317481269 0.312770489449031 17.5444383172066 0.00157987552496832 0.0118205076165161 G1R5U7,Cytokine inducible SH2 containing protein XP_003257168.1,cytokine-inducible SH2-containing protein isoform X2 PF07525,SOCS box;PF00017,SH2 domain IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR028425,Cytokine-inducible SH2-containing protein;IPR035887,CIS, SH2 domain ENOG4111V4J,-;KOG4566,Cytokine-inducible SH2 protein GO:0016567,biological_process,protein ubiquitination;GO:0005622,cellular_component,intracellular;GO:0035556,biological_process,intracellular signal transduction K04701,ko04917,Prolactin signaling pathway;K04701,ko04630,Jak-STAT signaling pathway Ccrl2 1.15715445498374 1.03061824147553 1.02590119469937 0.306757494801004 0.331002333912683 0.437590275584937 1.58314850520215 0.976454784250359 63.1433274920613 7.86446928406836e-06 0.000185016569925604 D3ZVM9,C-C motif chemokine receptor-like 2 NP_001101661.1,C-C chemokine receptor-like 2 PF00001,7 transmembrane receptor (rhodopsin family) IPR000355,Chemokine receptor family;IPR017452,GPCR, rhodopsin-like, 7TM;IPR000276,G protein-coupled receptor, rhodopsin-like ENOG411157E,-;ENOG410IKE4,- GO:0042379,molecular_function,chemokine receptor binding;GO:0048020,molecular_function,CCR chemokine receptor binding;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0070098,biological_process,chemokine-mediated signaling pathway;GO:0004950,molecular_function,chemokine receptor activity;GO:0007165,biological_process,signal transduction;GO:0006935,biological_process,chemotaxis;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0006954,biological_process,inflammatory response - Gm26797 0.634982784351087 0.375191932517378 0.336261746279315 0.151593238129234 0.212646899976545 0.174028236630466 1.28219341754762 0.452376995702351 18.978275443371 0.00119668078097909 0.0094006086429768 Q3UPP0,Uncharacterized protein - - - - - - Csprs 5.85077975671303 4.56269364469935 4.22106315428024 2.41249013918442 2.21390527566607 2.15031488966049 1.12249340361323 3.29373392325166 87.3612575107519 1.67707938659926e-06 5.50595786406324e-05 Q8BYZ8,Uncharacterized protein NP_291094.2,component of Sp100-rs - IPR017452,GPCR, rhodopsin-like, 7TM ENOG410YPW5,-;ENOG410J1CI,- GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane - mt-Tq 3.5285061901969 13.827703335628 10.7255183252674 23.3129049082462 27.5881898307599 28.2118060569267 -1.39597848818241 0.468981554022309 18.4447024971811 0.00132476266966741 0.0102393534145288 - - - - - - - Gm14636 0.303817018944761 0.210108489833697 0.248337623412833 0.122451173775499 0.115875216622973 0.115857115949867 1.09935443596678 0.490997799136967 22.7667637666366 0.000611807660396237 0.00549144452743342 - - - - - - - Il13ra2 1.64746124180609 1.34992464710936 1.62155703871708 0.483769179741481 0.837784659267523 0.427203433069331 1.37579474683922 1.34129377655484 35.6708022232552 0.000100645727408808 0.00134057370249284 G3V9B6,Interleukin-13 receptor subunit alpha-2 XP_008771611.1,-;XP_006257490.1,-;NP_598222.2,interleukin-13 receptor subunit alpha-2 precursor;XP_008771610.1,-;XP_006257492.1,-;XP_006257489.1,-;XP_008771612.1,-;XP_006257493.1,- PF09240,Interleukin-6 receptor alpha chain, binding IPR003532,Short hematopoietin receptor, family 2, conserved site;IPR015321,Type I cytokine receptor, cytokine-binding domain;IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR013783,Immunoglobulin-like fold ENOG410IUDW,-;ENOG4111JMU,- GO:0016064,biological_process,immunoglobulin mediated immune response;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0043305,biological_process,negative regulation of mast cell degranulation;GO:0002638,biological_process,negative regulation of immunoglobulin production;GO:0016020,cellular_component,membrane;GO:0004896,molecular_function,cytokine receptor activity;GO:0016021,cellular_component,integral component of membrane K05077,ko04630,Jak-STAT signaling pathway