ReadMe for "The relation of local entropy and information transfer suggests an origin of isoflurane anesthesia effects in local information processing", Patricia Wollstadt, Kristin K. Sellers, Lucas Rudelt, Viola Priesemann, Axel Hutt, Flavio Fröhlich, Michael Wibral 2017-03-14 This readme file describes the data files accompanying the above publication for one of two animals. ################ Contents Files contain epochs of local field potentials (LFP) simultaneously recorded in the prefrontal (PFC) and primary visual cortex (V1) of one of two ferrets (Mustela putorius furo, 15–20 wk old). Recordings were conducted in the awake animal as well as after administration of isoflurane in concentrations of 0.5 % and 1.0 %. Recordings for each animal were collected over multiple sessions and were cut into epochs of approximately 4.81 s length to allow for the rejection of data segments due to movement artifacts (identified through visual inspection of the raw data). Provided data are sampled at 1000 Hz (downsampled from the original sampling rate of approximately 20 kHz). Files furthermore contain lists of epochs used for analysis in the above publication for each recording session. Epochs contaminated by movement artifacts were excluded. Additionally, 0.0 % isoflurane epochs with a relative delta power (0.5 to 4.0 Hz) of more than 30 % of the total power from 0.5 to 50 Hz were rejected to ensure that only epochs during which the animal was truly awake entered further analysis. Details on data collection can be found in the above publication and in references [1] and [2]. The following files are included: 1) ferret_2_iso_*_recording_*_pfc.csv Epochs of LFP data recorded from the PFC in animal 2 for different isoflurane concentrations and recording sessions. Isoflurane concentration and recording session are indicated by the file name, e.g., ferret_2_iso_0_0_recording_1_pfc.csv for 0.0 % isoflurane (awake state) and recording session 1; or ferret_2_iso_0_5_recording_4_pfc.csv for 0.5 % isoflurane and recording session 4. Each file contains a 2-dimensional data matrix, where rows represent epochs and columns represent samples (4808 samples, i.e., 4.808 s sampled at 1000 Hz). 2) ferret_2_iso_*_recording_*_v1.csv Epochs of LFP data recorded from the V1 in animal 2 for different isoflurane concentrations and recording sessions. Epoch numbers correspond to PFC recordings described under 1). Isoflurane concentration and recording session are indicated by the file name, e.g., ferret_2_iso_0_0_recording_1_v1.csv for 0.0 % isoflurane (awake state) and recording session 1; or ferret_2_iso_0_5_recording_4_v1.csv for 0.5 % isoflurane and recording session 4. Each file contains a 2-dimensional data matrix, where rows represent epochs and columns represent samples (4808 samples, i.e., 4.808 s sampled at 1000 Hz). 3) ferret_2_iso_*_recording_*_select_trials.csv Lists of epochs used for analysis in the above publication for animal 2 for each isoflurane concentration and recording session. The lists contain remaining epochs after rejection of movement artifacts. Additionally, for recordings under isoflurane concentration of 0.0 % epochs with excessive delta power were excluded. Isoflurane concentration and recording session are indicated by the file name, e.g., ferret_2_iso_0_0_recording_1_select_trials.csv for 0.0 % isoflurane and recording session 1; or ferret_2_iso_0_5_recording_4_select_trials.csv for 0.5 % isoflurane and recording session 4. ################ Analysis steps Prior to the analysis steps described in the above publication, the first 6 samples were removed from each epoch. ################ References Details on data collection and surgical procedures can be found in: [1] Sellers KK, Bennett DV, Hutt A, Fröhlich F. Anesthesia differentially modulates spontaneous network dynamics by cortical area and layer. J Neurophysiol. 2013;110(12):2739–2751. [2] Sellers KK, Bennett DV, Hutt A, Williams J, Fröhlich F. Awake versus anesthetized: layer-specific sensory processing in visual cortex and functional connectivity between cortical areas. J Clin Neurophysiol. 2015;113:3798–3815. ################ Contact For any further queries please contact Kristin K. Sellers Center for Integrative Neuroscience, University of California, San Francisco, USA email: kristinksellers@gmail.com Flavio Fröhlich Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, USA email: flavio_frohlich@med.unc.edu