The data submission contains 4 experimental data used in Figure 5-8 in our manuscript. Here are how they map to each figure: Figure 5 : blood_vessel_10Hz.mat Figure 6 : PFC4_15Hz.mat Figure 7 : bma22_epm_motioncorrected_round1_cropped_correction.mat Figure 8 : CaMKII_120_TMT Exposure_5fps.mat Each mat file has two variables: Y: uint16 row*column*T 3D matrix. It represents a motion corrected video data Z: double 3X1 vector, which encode the size of Y [row, column, T] Please contact Pengcheng Zhou (pz2230@columbia.edu) if anything is not clear.