The files included in this supplement are: 1) data.csv Main dataset used on this study. The data consists of optical density measurements of E. coli under antibiotic treatments (single drugs or pairs) after 24 hours of growth on LB supplemented with the antibiotic(s) at seven different growth temperatures. The 'OD' column contains the optical density values (after subtracting a negative control). The 'drug1name' and 'drug2name' columns consist of the antibiotic names for each condition. The absence of an antibiotic is denoted as 'WT'. The 'drug1num' and 'drug2num' columns are a numerical value that is assigned to each antibiotic for processing purposes. The 'T' column contains the temperature in Celsius. The 't' column corresponds to the time of measurement after culture inoculation (24 hours). The 'sample' column contains the replicate number of the measurement. 2) get_fr_advi_params.py This file contains the Python 3 code used for the Bayesian estimation of the parameters of the extended Briere model (see manuscript and Supplemental Information for details). The code should be run in the same directory as the dataset (file 'data.csv'). The output of the code is three csv files. The first one ('advi_params_fr.csv') corresponds to the posterior mean of the parameters of the extended Briere model. The other two correspond to the lower and upper values of the 95% credible interval (files 'advi_params_lo_fr.csv' and 'advi_params_hi.csv') for each parameter. The following Python 3 libraries need to be installed to run the code: -- numpy -- pandas -- theano -- pymc3 -- pickle 3) conc_data_ERY_TMP.csv Dataset used to generate Supplemental Figures 4 and 5, of E. coli growing under two antibiotic backgrounds at varying concentration and temperature. The 'drug' column corresponds to the antibiotic name (ERY or TMP). The 'T' column corresponds to the temperature (in Celsius). The 'concentration' column corresponds to the antibiotic concentration as a fraction of the maximum concentration used for each drug (1000 ug/ul for ERY and 0.14 ug/ul for TMP). The 'od' column corresponds to the raw optical density values (without subtracting a negative control). The 'bacteria' column (True/False) indicates whether the culture was inoculated with E. coli. This is False for the negative control and True for all other conditions.