This repository contains R scripts and other supplementary materials associated with the study by Miller and Stroud (2021) titled "Novel Tests of the Key Innovation Hypothesis: Adhesive Toepads in Arboreal Lizards" in Systematic Biology. Within this repository, we provide all Supplementary Tables, the Supplementary Figures document, as well as R scripts to replicate our analytical pipeline and reproduce the results we present. For any questions or inquiries, please e-mail aryehmiller(at)wustl(dot)edu. Supplementary Table 1 (Full_Dataset_2692_TableS1.csv): The "Full" dataset comprising 2692 species with all associated data. Supplementary Table 2 (StandardEcologyLimbed_TableS2.csv): The "Standard" dataset comprising 2360 species with all associated data. Supplementary Table 3 (simmap_results_TableS3.csv): Stochastic character mapping results. Supplementary Table 4 (fitPagel_TableS4.csv): Pagel's test for evolutionary correlation results across all datasets. Supplementary Table 5 (SSE_TableS5.csv): SSE model log likelihoods and AIC values across all datasets. Supplementary Table 6: corHMM model results across all datasets. 5644Species_SamplingFractionReference.csv: Dataset used to calculate sampling fractions for SSE models. FullRelaxed_TraitAnalysis.csv: Table used in R pipeline for Full Relaxed dataset analysis. FullStrict_TraitAnalysis.csv: Table used in R pipeline for Full Strict dataset analysis. StandardRelaxed_TraitAnalysis.csv: Table used in R pipeline for Standard Relaxed dataset analysis. StandardStrict_TraitAnalysis.csv: Table used in R pipeline for Standard Strict dataset analysis. FullTree.tre: Full dataset tree used in analysis. StandardTree.tre: Standard dataset tree used in analysis. Supplement_MillerStroud2021_SystBiol.pdf: Supplementary figures document.