Author of 4 Dryad datasets

• Data from: Diffusive spreading across dynamic mitochondrial network architectures

  Published Feb 04, 2026. Holt, Keaton; Zurita, Camryn; Teryoshin, Lizzy; Lewis, Samantha; Koslover, Elena

  Networks of physical units can vary from a stationary set of spatially-embedded links to a collection of mobile agents that undergo transient social interactions. In living cells, mitochondria form architectures that span across these regimes, transitioning between fragmented, partly connected, and highly fused structures depending on cell type and state....

  Subjects: Fluorescence imaging Mass diffusivity Membrane fusion Mitochondria Social networks Spatial networks Biological sciences Physical sciences

• Data from: Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress

  Published May 21, 2025. Begeman, Adam; Smolka, John; Shami, Ahmad; Waingankar, Tejashree; Lewis, Samantha

  Protein- and RNA-rich bodies contribute to the spatial organization of gene expression in the cell and are also sites of quality control critical to cell fitness. In most eukaryotes, mitochondria harbor their own genome, and all steps of mitochondrial gene expression co-occur within a single compartment – the matrix. Here,...

  Subjects: Cellular stress responses DNA transcription Fluorescence imaging Mitochondria Mitochondrial DNA Protein translation Biological sciences

• Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation

  Published May 19, 2025. Begeman, Adam; Babaian, Artem; Lewis, Samantha

  RNA viruses are ubiquitous components of the global virosphere, yet relatively little is known about their genetic diversity or the cellular mechanisms by which they exploit the biology of their diverse eukaryotic hosts. A hallmark of (+)ssRNA (positive single-stranded RNA) viruses is the ability to remodel host endomembranes for their...

  Subjects: Metaanalysis Mitochondria Mitochondrial DNA Phylogenetics Protein translation RNA viruses Transcriptome analysis Biological sciences

• Impact of the POLRMT inhibitor IMT1B on mitochondrial genome copy number in Caenorhabditis elegans

  Published Feb 27, 2025. Kakudji, Eve; Lewis, Samantha

  POLRMT is the dedicated mitochondrial RNA polymerase in metazoans and is essential for priming mitochondrial DNA (mtDNA) synthesis. Aberrant POLRMT causes mitochondrial dysfunction and has previously been linked to human metabolic disease. The small molecule IMT1B is an allosteric inhibitor of POLRMT, and its use in diverse model organisms is...

  Subjects: Caenorhabditis elegans Mitochondria Mitochondrial DNA RNA polymerase Biological sciences