Preanesthetic administration of trazodone does not impact anesthetic recovery scores
Data files
Sep 02, 2025 version files 40.92 KB
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README.md
3.57 KB
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Trazodone_Recovery_Case_Controls.xlsx
37.35 KB
Abstract
Trazodone is administered to hospitalized equine patients to aid in behavioural management. The effects of trazodone on the recovery period have not been previously investigated. This retrospective study sought to determine if there was an association between trazodone administration and recovery quality, time, need for sedation, or reversal agent administration. We hypothesized that there would be no difference in recovery scores, recovery time, additional sedation, or reversal agent administration between horses that received trazodone preoperatively and horses that did not. Records were reviewed to identify horses undergoing orthopedic MRI between January 2022 and January 2025. 19 horses of these horses were administered trazodone prior to anesthesia. Thirty-eight horses that matched the case controls but did not receive trazodone were also selected. Signalment, anesthetic drug protocol, duration of anesthesia, duration of recovery, recovery scores, recovery complications, sedation agents, and reversal agents administered during recovery were recorded. Fisher's test, independent t-test, and logistic regression were used to investigate differences between groups. Significance level was set to 5% (p <0.05).
Dataset DOI: 10.5061/dryad.4qrfj6qpv
Description of the data and file structure
Retrospective data collected from medical records of horses anesthetized for orthopedic MRI from 2019 to 2025. Data collected included signalment, anesthetic protocols, recovery drugs administered, recovery times, and recovery complications.
Files and variables
File: Trazodone_Recovery_Case_Controls.xlsx
Description: Retrospective data collected from anesthesia records of horses undergoing anesthesia for a orthopedic MRI. 19 Horses had received trazodone prior to anesthesia. 38 horses were selected as a control group. Page 1 details data collected from control horses. Page 2 details data collected from trazodone cases. Empty cells represent that there was no data to correlate with category (ie. no sedative agent administered, no complication experienced)
Variables
- Medical record number
- Visit number
- Date of anesthesia
- Sex (Male/Female/ Male Castrated)
- Age (Year)
- Weight (Kg)
- Breed
- ASA Status (I-V)
- Billed for
- Procedure
- Trazodone administration prior to anesthesia (Yes/No)
- Trazodone dose (mg and mg/kg)
- Trazodone administration frequency
- Premedication administered (agent name)
- Premedication Dose (mg and mg/kg) and route
- Additional premedication agent name
- Additional premedication dose (mg, mg/kg) and route
- Opioid administered (agent name)
- Opioid dose (mg and mg/kg) and route
- Induction agent administered (agent name)
- Induction agent dose (mg and mg/kg) and route
- Co-induction agent administered (agent name)
- Co-induction agent dose (mg and mg/kg) and route
- Maintenance agent (agent name)
- CRI administration (agent name)
- Other drugs administered during anesthesia
- Recovery sedation administered (Y/N and agent name)
- Recovery sedation dose (mg and mg/kg) and route
- Additional recovery sedative administered (Y/N and agent name)
- Additional recovery sedative dose (mg and mg/kg) and route
- Tertiary recovery sedation administered (Y/N and agent name)
- Tertiary recovery sedation dose (mg and mg/kg) and route
- Reversal agent administered (Y/N and agent name)
- Reversal agent dose (mg and mg/kg)
- Additional reversal agent administered (Y/N and agent name)
- Additional reversal agent dose (mg, mg/kg) and route
- Patient position during position (Left or Right lateral recumbency)
- Patient position during recovery (Left or Right lateral recumbency)
- Presence of low SpO2 reading (Yes/No)
- Presence of Hypoxemia (Yes/No)
- Presence of tachycardia (Yes/No)
- Presence of bradycardia (Yes/No)
- Presence of hypotension (Yes/No)
- Presence of hypertension (Yes/No)
- Presence of intra-operative complication (Yes/No)
- Details of Ax Complication (Description of complication experienced during anesthetic period)
- Recovery score (1-5)
- Recovery complication (Yes/No)
- Details of recovery complication (Description of complication experienced during recovery period)
- Anesthesia start time (24 hour clock time)
- Anesthesia end time (24 hour clock time)
- Duration of anesthesia (minutes)
- Duration of recovery (minutes)
- Alive at 24 hours post procedure (Yes/No)
- Cause of death (Description of cause of death)
Routes: Intravenous - IV, Intramuscular - IM, Subcutaneous - SQ, Oral - PO
Code/software
Excel
Access information
Other publicly accessible locations of the data:
- None
Data was derived from the following sources:
- None