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Data from: Stable excitatory-inhibitory synapse balance despite dynamic turnover

Garbett, Krassimira1; Allen, James1; Sando, Richard1

Published Jul 28, 2026 on Dryad. https://doi.org/10.5061/dryad.5qfttdzp5

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Abstract

Functional balance between excitatory and inhibitory synapses is critical for neural circuit behavior. How this balance is established and maintained during development is poorly understood. To address this, we concurrently imaged fluorescently-tagged pre- and post-synaptic compartments in primary hippocampal neuronal cultures over relative long time periods (15 hours). We observed continual turnover of subsets of excitatory and inhibitory synaptic structures, yet densities of excitatory and inhibitory synapses remained stable through development.