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Patch-clamp recordings from dorsal raphe neurons

Data files

Sep 14, 2021 version files 743.46 MB
Feb 22, 2023 version files 970.56 MB

Abstract

This dataset contains whole-cell electrophysiological recordings (patch-clamp recordings) from three cell types in mice:

  • serotonin (5-HT) neurons,
  • somatostatin (SOM)-expressing GABA interneurons, and
  • layer 5 pyramidal neurons.

5-HT and GABA neurons were recorded in the dorsal raphe nucleus (DRN), which is the main source of serotonergic input to the forebrain. Together, they make up the majority of the neurons found in the DRN.

This dataset can be used to investigate the intrinsic electrophysiological properties of these two types of DRN neurons and contrast them with another abundant and well-studied cell type, the L5 pyramidal neuron.

This data was used in our paper describing a spiking neural network model of the dorsal raphe nucleus:

Emerson F. Harkin, Michael B. Lynn, Alexandre Payeur, Jean-François Boucher, Léa Caya-Bissonnette, Dominic Cyr, Chloe Stewart, André Longtin, Richard Naud, and Jean-Claude Béïque. Temporal derivative computation in the dorsal raphe network revealed by an experimentally-driven augmented integrate-and-fire modeling framework. eLife, 2023. doi: 10.7554/eLife.72951