3D-T1 image of Cushing disease
Data files
Dec 18, 2019 version files 1.04 MB
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FigureS1.tif
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raw.xlsx
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TableS1_AAL_186_ANOVA.xlsx
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TableS2_AAL_186__post_hoc.xlsx
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TableS3_AAL_186_Type.xlsx
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TableS4_AAL_186_dura_co.xlsx
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TableS5_AAL_186_heromo_co.xlsx
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Abstract
Background: The adverse effects of hypercortisolism on total human brain had been highlighted in previous neuroscience studies of Cushing’s disease (CD). However, the regional alterations associated with hypercortisolism remains unclear. The present study was carried out to examine gray matter (GM) alterations according to the different stages of chronic hypercortisolism exposure.
Design: Although longitudinal studies have been traditionally used to address the question of reversibility of brain alterations in CD, these studies would probably ignore the irreversible alterations induced by hypercortisolism. Thus, information from cross-sectional neuroimaging studies may provide more useful contributions to further clarify this issue.
Conclusion: Our study enhances the understanding of the structural alterations due to hypercortisolism. Furthermore, our study may facilitate the development of future studies with neuropsychological tests.