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Post-processed data for: Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns

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Oct 09, 2024 version files 75.69 GB

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Abstract

This study employs two-photon calcium imaging to investigate neural activity in mice during a neuroprosthetic task. Using two-photon microscopy, we captured GCaMP8s fluorescence at a wavelength of 920nm. Mice, head-fixed on a spherical treadmill, controlled a neural cursor by modulating activity in two motor cortex neuron ensembles. The task provided auditory feedback and measured neuronal activity using dF/F ratios. Contrary to traditional neuroprosthetics, we delivered activation of dopamine receptors with photoswitches instead of water reward. We explored various experimental conditions to assess the effect of receptor activation on task performance and neuronal activity. This data set contains the post-processed data.