Data from: Intravenous nalbuphine for prevention of intrathecal morphine-induced nausea and vomiting in patients undergoing caesarean section: A double-blind, randomized controlled trial
Data files
Sep 28, 2026 version files 269.47 KB
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CONSORT_checklist.docx
38.25 KB
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consort_diagram_nalbuphine.jpg
74.73 KB
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inform_consent_E.pdf
32.21 KB
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inform_consent.pdf
88.98 KB
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nalbuphine_data_for_analysis1.xlsx
20.35 KB
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NV.xlsx
12.72 KB
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README.md
2.24 KB
Abstract
Introduction: Postoperative nausea vomiting (PONV) is quite common among patients who underwent caesarean section under spinal anesthesia with intrathecal morphine (ITMO). Nalbuphine is a mu receptor antagonist and kappa receptor agonist, which may mitigate opioid-related side effects. We hypothesized that intravenous nalbuphine administration could possibly reduce the incidence of PONV.
Dataset DOI: 10.5061/dryad.dr7sqvbd3
Description of the data and file structure
In this study, we aim to evaluate the efficacy of IV nalbuphine 4 mg in PONV (Postoperative Nausea and Vomiting) prevention after intrathecal morphine in patients who underwent cesarean section.
Files and variables
File: NV.xlsx
Description: Incidence of nausea and vomiting at 0, 6, and 24 hours
Variables
- ID
- NV0h = incidence of nausea/vomitingg at 0 h
- NV6h = incidence of nausea/vomitingea vomiting at 6 h
- NV24h = incidence of nausea/vomiting at 24 h
- group; 1=Nalbuphine group, 2=control group
File: CONSORT_checklist.docx
Description: checklist of CONSORT
File: consort_diagram_nalbuphine.jpg
Description: consort diagram of the study
File: inform_consent.pdf
Description: Thai version of inform consent
File: nalbuphine_data_for_analysis1.xlsx
Description: Patients' Characteristics
Variables
- Volunteer code = ID
- Random = group (P=control group, N=nalbuphine group)
- NPO (hr) = hours of NPO
- AN time (min) = anesthesia time in minutes
- OP time (min) = Operation time in minutes
- Fluid (ml) = amount of intravenous fluid given in ml
- Blood loss (ml) = amount of blood loss in ml
- Hypotension; Y=yes, N=no
- Ephedrine (mg) = amount of ephedrine used
- Levophed (mcg) = amount of levophed (norepinephrine) in microgram given
- Methergin = methergin use; Y=yes, N=no
- dose methergin = amount of methergin used
File: inform_consent_E.pdf
Description: English translation of inform consent
Code/software
Excel and PDF
Access information
Other publicly accessible locations of the data:
- NA
Data was derived from the following sources:
- NA
Human subjects data
All participant data were de-identified prior to analysis. Direct identifiers such as names, addresses, and dates of birth were removed, and indirect identifiers were aggregated to minimize the risk of re-identification.
In this randomized controlled trial, every patient receives spinal anesthesia with 0.2 mg of morphine for caesarean section. After umbilical cord clamping, patients in the study group received a single dose of 4 mg of intravenous (IV) nalbuphine. The primary outcome was the incidence of PONV in the first 24 hours. Secondary outcomes were the severity of nausea and vomiting, pain scores, incidence of pruritus and respiratory depression.