Substance use refers that using psychoactive substances such as khat, alcohol, cigarette, and illicit drugs. Youth are more vulnerable to substance use than older people. Substance use has a different impact on the health as well as socio-economics of one country. Globally substance use was the major public health concern. Currently, substance use is a common public health concern among the youth of Ethiopia mainly in Jimma town. Therefore, this study aimed to explore the substance use and risk factors among the youth of Jimma town, 2019.