Populations of the northern bay scallop, Argopecten irradians irradians, across the northeast US have recently experienced severe declines. Here we used high-resolution satellite-based temperature records, long-term temperature and dissolved oxygen records, field and laboratory experiments, and high-frequency measures of scallop cardiac activity in an ecosystem setting to quantify decadal summer warming and assess the vulnerability of northern bay scallops to thermal- and hypoxic-stress across their geographic distribution. This set of files contains the raw data analyzed for this study. The data are grouped into relevant subfolders: Commercial Landings Data; Field Deployment Data; Gonad Index Data; Laboratory Data; Optical Infrared Sensor Data; Remote Sensing Data.