This dataset includes 523 gestational diabetes mellitus (GDM) patients and 638 healthy pregnancies’ baseline information obtained from a unique questionnaire and medical records, and the genetic loci were genotyped by the Sequenom MassARRAY platform. Evaluate the relationship between certain genetic variations and the risk of GDM by integrating clinical, biochemical, and genetic data.

Subjects’ baseline data involve age, pre-BMI, systolic blood pressure (SBP, mmHg), diastolic blood pressure (DBP, mmHg), triglyceride (TG, mmol/L), total cholesterol (TC, mmol/L), high-density lipoprotein cholesterol (HDL-c, mmol/L), low-density lipoprotein cholesterol (LDL-c, mmol/L), fasting plasma glucose (FPG, mmol/L), oral glucose tolerance test 1h plasma glucose (1hPG, mmol/L), oral glucose tolerance test 2h plasma glucose (2hPG, mmol/L), glycated hemoglobin (HbA1c, %). The data of genetic polymorphism include rs1391371 A>T, rs9272425 T>C, rs9272426 A>G, rs9272460 A>G, rs9273368 A>G, rs9273505 C>,T and rs9274666 A>G and their corresponding dominant and recessive genetic model.

The meaning of the different assignments in the dataset：
(1)Group: 1=Control group; 2=GDM
(2)Sample ID: Identification number of test sample
(3)Variants and genotypes assignment

1. rs1391371 A>T: 1=AA genotype; 2=AT genotype;3=TT genotype
2. rs9272425 T>C: 1=TT genotype; 2=TC genotype;3=CC genotype
3. rs9272426 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
4. rs9272460 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
5. rs9273368 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
6. rs9273505 C>T: 1=CC genotype; 2=CT genotype;3=TT genotype
7. rs9274666 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
8. rs1391371 Dominant model (AT/TT vs. AA): 1=AA genotype; 4=AT/TT genotypes
9. rs9272425 Dominant model (TC/CC vs. TT): 1=TT genotype; 4=TC/CC genotypes
10. rs9272426 Dominant model (AG/GG vs. AA): 1=AA genotype; 4=AG/GG genotypes
11. rs9272460 Dominant model (AG/GG vs. AA): 1=GG genotype; 4=AG/GG genotypes
12. rs9273368 Dominant model (AG/GG vs. AA): 1=AA genotype; 4=AG/GG genotypes
13. rs9273505 Dominant model (CT/TT vs. CC): 1=CC genotype; 4=CT/TT genotypes
14. rs9274666 Dominant model (AG/GG vs. AA): 1=AA genotype; 4=AG/GG genotypes
15. rs1391371 Recessive model (TT vs. AA/AT): 3=TT genotype; 5=AA/AT genotypes
16. rs9272425 Recessive model (CC vs. TT/TC): 3=CC genotype; 5=TT/TC genotypes
17. rs9272426 Recessive model (GG vs. AA/AG): 3=GG genotype; 5=AA/AG genotypes
18. rs9272460 Recessive model (GG vs. AA/AG): 3=GG genotype; 5=AA/AG genotypes
19. rs9273368 Recessive model (GG vs. AA/AG): 3=GG genotype; 5=AA/AG genotypes
20. rs9273505 Recessive model (TT vs. CC/CT): 3=TT genotype; 5=CC/CT genotypes
21. rs9274666 Recessive model (GG vs. AA/AG): 3=GG genotype; 5=AA/AG genotypes
    (4)Number of risk genotypes: Cumulative number of dangerous genotypes in the test samples
    (4)Variables for stratification analysis
22. Age_M (Mean Age value:30.04 mmHg,1="≤30.04 years old"；2= “＞30.04 years old” );
23. pre-BMI_M (Mean pre-BMI value:22.2 kg/m2),1="≤22.2 kg/m2"；2= “＞22.2 kg/m2" );
24. SBP_M (Mean SBP value:110.03 mmHg,1="≤110.03 mmHg"；2= “＞110.03mmHg” );
25. DBP_M (Mean DBP value:69.44 mmHg,1="≤69.44 mmHg"；2= “＞69.44 mmHg );
26. TG_M (Mean TG value:2.53 mmol/L,1="≤2.53 mmol/L"；2= “＞2.53 mmol/L”);
27. TC_M (Mean TG value:5.33 mmol/L,1="≤5.33 mmol/L"；2= “＞5.33 mmol/L”);
28. HDL-c_M (Mean TG value:1.65 mmol/L,1="≤1.65 mmol/L"；2= “＞1.65 mmol/L”);
    (5)NA: missing value

Detailed data can be found in the table file: Data_from__Genetic_variants_in_HLA-DQA1_DQB1_genes.xlsx

Human subjects data

All participants were provided written informed consent. The personal identity information data of the subjects have all been anonymized.