Concordance analysis was performed to identify the best post-dose T assay time-point to guide any necessary dose-adjustment in oral TU patients.  Concordance is defined herein to describe the extent of agreement between a decision to adjust the oral TU dose (up or down) when a single circulating T concentration in remains in the hypogonadal range [i.e., <252 ng/dl (9 nmol/L) for this study] or supraphysiological range [i.e., >907 ng/dL (31 nmol/L)] and the desired outcome of that decision (i.e., a circulating T level in the eugonadal range) is achieved.