Data from: Sepiolite reinforced alginate-based hydrogels for drug delivery applications
Data files
Aug 03, 2026 version files 7.33 MB
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Biodegradation_Data.opj
36.19 KB
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Calibration_curve_data_for_cephradine_drug_release.opj
649.09 KB
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Cell_Viability_descriptive_data_of_Hydrogels.opj
62.25 KB
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Cephradine_release_data_in_PBS.opj
37.67 KB
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Drug_encapsulation_dataset.opj
28.50 KB
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Hydrogel_IR_dataset.opj
477.09 KB
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IR_dataset_of_sepiolite_clay_and_drug_loaded_DSAP-5.opj
252.16 KB
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Korsmeyer-Peppas_model_cephradine_release_from_DSAP-5.opj
297.16 KB
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README.md
6.18 KB
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Swelling_data_in_CaCl2.opj
78.37 KB
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Swelling_data_in_distilled_water.opj
21.62 KB
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Swelling_data_in_NaCl.opj
36.74 KB
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Swelling_data_in_non-buffers.opj
36.78 KB
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Swelling_dataIn_Buffer.opj
36.76 KB
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Swelling_parametrs_calculated_from_swelling_data.opj
4.24 MB
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TGA_datasets_of_hydrogels.opj
260.96 KB
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XRD_data_of_Hydrogels.opj
476.93 KB
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Zero_Order_kinetics_cephradine_release_from_DSAP-5.opj
301.85 KB
Abstract
Cephradine (CD) is a first-generation bactericidal cephalosporin widely used for the treatment of urinary, respiratory, and skin infections. However, when it is taken directly, 8-17% of this drug binds to the serum, while almost 83-92% of this drug is released via the urinary tract without producing therapeutic action. On the other hand, alginate-based hydrogels demonstrated lower stabilities and lesser drug loading efficacy. Consequently, in the present work, we have prepared sepiolite (SEP) reinforced sodium alginate (SA)/poly(ethylene glycol) (PEG) hydrogels cross-linked with 3-aminopropyl(triethoxy)silane (APTS) crosslinker. The fabricated hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA), which confirmed the development of hydrogel interfaces. Hydrogels exhibited good swelling capability in distilled water that obeyed a non-Fickian diffusion process. The maximum swelling was exhibited at pH 8 in buffer and non-buffer solutions. In addition, the swelling abilities of hydrogels decreased by the increase in the amount of APTS. Biodegradation test confirmed their degradable nature up to 7 days. In 7 h, 81.32% of the CD was released and determined by UV-Visible spectrophotometer. The biodegradable and pH-responsive SA/PEG/SEP hydrogel platform could be a valuable choice for sustained delivery of drugs to deal with urinary and lower gastrointestinal infections.
Dataset DOI: 10.5061/dryad.ksn02v7j8
Description of the data and file structure
Hydrogel Methodology
Hydrogels are prepared by the solution casting method.
Data codes:
- SEP is sepiolite clay
- SA is sodium alginate
- PEG is poly(ethylene glycol)
- APTS is 3-aminopropyltriethoxy silane, an FDA-approved non-toxic cross-linker
Hydrogel codes:
- SAP(cont): It contains SA (0.6g), PEG (0.5g), and APTS 100µL.
- SAP-5: It contains SA (0.6g), PEG (0.5g), sepiolite (5mg), and APTS 100µL.
- SAP-10: It contains SA (0.6g), PEG (0.5g), sepiolite (10mg), and APTS 100µL.
- SAP-15: It contains SA (0.6g), PEG (0.5g), sepiolite (15mg), and APTS 100µL.
- SAP-20: It contains SA (0.6g), PEG (0.5g), sepiolite (20mg), and APTS 100µL.
- DSAP-5: It contains SA (0.6g), PEG (0.5g), sepiolite (5mg), cephradine drug (50mg), and APTS 100µL.
Files and variables
File: Biodegradation_Data.opj
Description: It provides data proving hydrogels are biodegradable. This worksheet is used to produce Figure 7 in the article. The unit along the y-axis is weight loss in mg. On the other hand, the unit on the x-axis is the number of days.
File: Cell_Viability_descriptive_data_of_Hydrogels.opj
Description: The suggested non-toxicity of the reported material against 3T3 fibroblasts. This data is used to make Figure 11 of the paper. The y-axis unit is % viability, and the x-axis data shows the hydrogel sample.
File: Cephradine_release_data_in_PBS.opj
Description: The data confirms that in 7 hours, 81.32% of the cephradine was released and determined by UV-Visible spectrophotometer. The numerical values depicted in the origin sheets describe drug release % along the y-axis corresponding to the time in mins along the x-axis of Figure 13 in the accepted manuscript.
File: Drug_encapsulation_dataset.opj
Description: The dataset shows drug encapsulation as a function of sepiolite clay. The data in the worksheets describe the cephradine loading efficacy in % as the amount of sepiolite was increased in hydrogel samples shown in Figure 12.
File: Calibration_curve_data_for_cephradine_drug_release.opj
Description: Drug calibration for computing the amount of drug release in phosphate buffer saline solution. This data was used to compute a straight line in order to calculate the amount of cephradine release from hydrogels in PBS solution.
File: Swelling_data_in_distilled_water.opj
Description: Depicted swelling values (%) of hydrogels in distilled water. This data belongs to Figure 8, where swelling in % is taken on the y-axis and time in mins taken in x-axis to get Figure 12 and swelling equilibrium.
File: Swelling_data_in_NaCl.opj
Description: Depicted swelling values (%) of hydrogels in NaCl.The swelling data in % is plotted on the y-axis, while time in mins is shown on the x-axis to acquire Figure 8a of the paper
File: Swelling_dataIn_Buffer.opj
Description: Depicted swelling values (%) of hydrogels in Buffer solution of pH 2, 4, 6, 7, 8, and 10. The swelling data in % is plotted on the y-axis, while variable pHs are shown on the x-axis to acquire Figure 9b of the paper.
File: Swelling_data_in_non-buffers.opj
Description: Depicted swelling values (%) of hydrogels in non-buffer solution of pH 2, 4, 6, 7, 8 and 10. The swelling data in % is plotted on the y-axis, while variable pHs are shown on the x-axis to acquire Figure 9a of the paper.
File: Swelling_data_in_CaCl2.opj
Description: Depicted swelling values (%) of hydrogels in CaCl2. The swelling data in % is plotted on the y-axis, while time in mins is shown on the x-axis to acquire Figure 8b of the paper.
File: Hydrogel_IR_dataset.opj
Description: IR data sets used in confirming hydrogel synthesis. The Y-axis shows intensity (a.u) and x-axis reflect Wave number (cm-1). The worksheet belongs to Figure 3a.
File: IR_dataset_of_sepiolite_clay_and_drug_loaded_DSAP-5.opj
Description: IR data which confirm drug loading. IR data of pure sepiolite clay is provided too. The data corresponds to Figure 3b, where the y-axis shows intensity (a.u) and the x-axis wave number (cm-1).
File: TGA_datasets_of_hydrogels.opj
Description: Thermal behavior of curves in TG analysis. The thermogram reflects hydrogel weight loss in mg along the y-axis and Temperature in degrees Celsius on the x-axis, as shown in Figure 4.
File: XRD_data_of_Hydrogels.opj
Description: XRD data confirming amorphous gel nature. Figure 6 of the manuscript is prepared from the data presented in the worksheet. The y-axis contains intensity (a.u) and x-axis 2theta values, which is unit less quantity.
File: Swelling_parametrs_calculated_from_swelling_data.opj
Description: The swelling kinetics calculated from swelling data of hydrogels acquired from distilled water. The data in the worksheet reflects the lnF (y-axis) and lnt (x-axis) values at swelling equilibrium to calculate the slope or n-value that confirms the nature of swelling and the diffusion mechanism. Both lnF and lnt are unitless quantities. It belongs to Figure 8b.
File: Korsmeyer-Peppas_model_cephradine_release_from_DSAP-5.opj
Description: Cephradine release data from DSAP-5 hydrogel. The worksheet shows the following data. The log of drug release in % units is plotted along the y-axis, and the log of time is taken on the x-axis to get the slope value shown in Figure 14a that confirms that drug release obeyed the Korsmeyer-Peppas model.
File: Zero_Order_kinetics_cephradine_release_from_DSAP-5.opj
Description: Cephradine release data from DSAP-5 hydrogel. The data of Figure 14b is given in the origin worksheet, where mt/mo is the unitless ratio of total drug loaded and drug released at time t. This is taken on the Y-axis, and time in min is plotted against x-axis to obtain graph Figure 14b. The slope value confirmed that this model is not obeyed.