Dataset File List

• File Name: Raw_Data_for_Efficacy_and_Safety_of_Intra-articular_Sodium_Hyaluronate_for_Ankle-involved_Kashin-Beck_Disease_A_12-month_Prospective_Self-controlled_Study2.4.2.csv
• File Format: Comma-Separated Values (CSV)
• File Description: This is the core longitudinal data file of the dataset, saved in comma-separated values (CSV) format. It can be opened and analyzed using common software such as Microsoft Excel, SPSS 25.0 (consistent with the "Code/software" section), R (via the read.csv() function), or Python (via the pandas.read_csv() function). The file contains complete data of 79 participants with ankle-involved Kashin-Beck Disease (KBD) across three time points (baseline, Week 4, and Month 12), including basic patient information, Graded Chronic Pain Scale (GCPS) scores, KBD Joint Dysfunction Index (JDI) scores, and EQ-5D-3L utility index. There are no redundant or missing core indicators in the file, except for the preset uncollected null values in Treatment Evaluation and Treatment Effect.

Variables

• Time: Assessment time point.
  • 1 = Baseline (Prior to the first injection)
  • 2 = Week 4 (Assessment one week after the third injection)
  • 3 = Month 12 (Assessment 12 months after the first injection)
• ID: Participant identification number.
• Gender:
  • 1 = male,
  • 2 = Female
• Age: Age of the participant in years.
• KBD Stage: KBD clinical stage.
  • 1 = KBD Stage I
  • 2 = KBD Stage II
  • 3 = KBD Stage III
• Education Level: Highest education level attained.
  • 1 = Illiterate
  • 2 = Primary school
  • 3 = Junior school and above
• Marital Status:
  • 1 = Married,
  • 2 = Unmarried (Single, Widowed, or Divorced)
• BMI Category: Body Mass Index classification.
  • 1 = Underweight (< 18.5 kg/m²),
  • 2 = Normal weight (18.5–23.9 kg/m²),
  • 3 = Overweight/Obese (≥ 24 kg/m²).
• Treatment Effect: Perceived efficacy of the treatment.
  • 1 = Effective
  • 2 = Partially effective
  • 3 = Ineffective
• Treatment Evaluation: Patient’s overall satisfaction with the treatment.
  • 1 = Very satisfied
  • 2 = Satisfied
  • 3 = Neutral
  • 4 = Dissatisfied
  • 5 = Very dissatisfied
• JDI Score: Joint Dysfunction Index score (range from 0 to 10; higher scores indicate worse function).
• EQ-5D Utility Index: EQ-5D utility index based on the 2018 Chinese value set (range from 0.170 to 1.000; higher scores indicate better quality of life).
• GCPS Pain Score: Grading Chronic Pain Scale intensity score (range from 0 to 100; higher scores indicate worse pain).

General information of participants (e.g., age, gender, KBD stage) in this dataset are raw records collected directly. BMI (calculated based on height and weight), Graded Chronic Pain Scale (GCPS) scores, KBD Joint Dysfunction Index (JDI) scores, and the EQ-5D-3L utility index are derived data calculated or converted from original survey records using standard methods. All data have not undergone subsequent statistical analysis (e.g., no averaging, standardization, etc.), and the calculation methods can be traced through the corresponding research article or supplementary explanations in the README to ensure data reproducibility.

Detailed Explanation of Null Values in the Dataset

Scope of Null Values: Null values only appear in two indicator columns—"Treatment Evaluation" and "Treatment Effect"—and are limited to two time points: "pre-injection (baseline)" and "4 weeks post-injection. " Data for these two indicators is complete with no null values at the "12 months post-injection" time point.

Core Meaning of Null Values: The "null" here represents "data not collected as preset in the study protocol," rather than "missing or omitted data." In the study design, "treatment evaluation" and "treatment effect" were defined as end-of-period evaluation indicators, so surveys were only conducted at the end of the treatment cycle (12 months post-injection). These two indicators were not included in the evaluation plan at pre-injection (baseline) or 4 weeks post-injection, hence they were marked as "null."

Explanation of Data Integrity:

Except for the above-mentioned preset uncollected "null" values, all other core indicators in the dataset (patient basic information, GCPS pain score, JDI joint function score, and EQ-5D-3L utility index) have no null values. All cases with missing core data have been excluded in advance to ensure data integrity.

Code/software

SPSS 25.0

Human subjects data

The study was conducted in compliance with the Declaration of Helsinki. All patients provided written informed consent prior to participation. Personal identifying information (e.g., name, ID number, contact details) has been completely removed from the dataset to protect patient privacy, and no ethical conflicts or legal restrictions on data reuse exist.