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Dryad

Modulation of DNA methyltransferases (DNMTs) in Spodoptera frugiperda (Sf9) cells following AcMNPV infection and its effects on the virus-cell interaction

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Jul 11, 2025 version files 5.72 KB

Abstract

In this study, we examined the gene expression profiles of Sf9 insect cells following infection with baculovirus, utilizing reverse transcription quantitative PCR (RT-qPCR) to analyze how the host cellular machinery responds at the transcriptional level to viral invasion. Our findings highlight the intricate regulatory mechanisms in place during virus replication. To further understand the relationship between the host response and viral propagation, we also quantified the dynamics of baculovirus replication within the Sf9 cells using quantitative PCR (qPCR). This dual approach provides a comprehensive view of both the efficiency of viral replication and the accompanying host transcriptional changes.