Data from: Effects of flow-controlled expiration on oxygenation and early recovery in horses undergoing general anaesthesia
Data files
Sep 07, 2026 version files 10.96 KB
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Data_collection_for_publication.xlsx
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README.md
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Abstract
Background
Flow-controlled EXpiration (FLEX) has been shown to significantly enhance oxygenation in horses under clinical and experimental conditions.
Objectives
To compare pulmonary gas exchange during early recovery following general anaesthesia in horses ventilated with FLEX compared with conventional intermittent positive pressure ventilation (IPPV), and to assess recovery characteristics between ventilation modes.
Study Design
Prospective, randomised, crossover
Methods
Six adult horses underwent two 2-hour anaesthetic episodes in a randomised crossover design (FLEX vs IPPV), separated by a two-week washout. Arterial blood gases were analyzed at 60- and 120-minutes post-induction. Arterial blood pressure, end-tidal inhalant concentrations, respiratory rate and hemoglobin oxygen saturation were recorded in five-minute intervals during anaesthesia. The initial recovery period was defined as the first 20 minutes following return of spontaneous ventilation, during which arterial blood gases, end-tidal inhalant concentrations, and oxygen saturation were recorded in five-minute intervals. Horses were recovered using head and tail rope assistance. The time to sternal recumbency, standing, and the number of standing attempts were recorded. Data were analysed using linear mixed-effects models for repeated measures and paired tests for recovery outcomes.
Results
PaO₂ was higher during general anaesthesia with FLEX (mean± SD: 422± 24 vs 202± 101 mmHg at 60 min; 433± 31 vs 180± 59 mmHg at 120 min; P<0.01). In recovery, PaO₂ remained higher with FLEX (20 min: 114± 21 vs 62± 11 mmHg; P<0.01) and EtIso declined more rapidly (P<0.01). Time to sternal and standing were shorter and attempts to stand fewer with FLEX (exploratory outcomes).
Main Limitations
This study enrolled a small sample size, which may limit generalizability. Recovery was recorded from one camera angle,potentially restricting full assessment of recovery behaviour. No respiratory mechanics or regional ventilation distribution were quantified.
Conclusions
FLEX improves oxygenation during early recovery and is associated with faster recovery times in healthy horses.
Dataset DOI: 10.5061/dryad.pk0p2nh4x
Description of the data and file structure
File: Data_collection_for_publication.xlsx
Table 1: treatment assignment in the table: Horses 1A–6A represent the FLEX mode, and Horses 1B–6B represent the IPPV mode
Description:
Six adult horses underwent two 2-hour anaesthetic episodes in a randomised crossover design (FLEX vs IPPV), separated by a two-week washout. Arterial blood gases were analyzed at 60- and 120-minute post-induction. Arterial blood pressure, end-tidal inhalant concentrations, respiratory rate and hemoglobin oxygen saturation were recorded in five-minute intervals during anaesthesia. The initial recovery period was defined as the first 20 minutes following return of spontaneous ventilation, during which arterial blood gases, end-tidal inhalant concentrations, and oxygen saturation were recorded in five-minute intervals. Horses were recovered using head and tail rope assistance. The time to sternal recumbency, standing, and the number of standing attempts were recorded. Data were analysed using linear mixed-effects models for repeated measures and paired tests for recovery outcomes.