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Dryad

Tuning reductase activity in monoterpene indole alkaloid biosynthesis

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May 30, 2026 version files 22.17 GB

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Abstract

Monoterpene indole alkaloids encompass a diverse class of plant natural products. Many of these valuable compounds, including the anticancer medicines vinblastine and vincristine (Catharanthus roseus) and the antiaddiction treatment ibogaine (Tabernanthe iboga) utilize a common biosynthetic intermediate, 19E-geissoschizine, which is produced by the medium-chain dehydrogenase/reductase geissoschizine synthase (GS). This dataset provides the raw data for the genome of Tabernanthe iboga.