Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus
Data files
Mar 25, 2024 version files 123.75 KB
Abstract
The dataset contains subjects’ basic information, including the Identification number of the test sample, fasting plasma glucose (FPG), oral glucose tolerance test 1h plasma glucose (1hPG), oral glucose tolerance test 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), Systolic blood pressure (SBP), Diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-c), Low-density lipoprotein cholesterol (LDL-c), and also involves subjects’ genetic variant information used for analysis of the association of functional polymorphisms and GDM. The variables including SBP_M, DBP_M, FPG_M, 1hPG_M, 2hPG_M, HbA1c_M, TG_M represent the mean value of SBP, DBP, FPG, 1hPG, 2hPG, HbA1c, TG, which are used for the stratification analysis. This study has obtained the support from the Ethics Committee of Guilin Medical University. All included subjects signed the informed consent.
Row Data for the Association of Functional Polymorphisms and GDM
- Sample ID: Identification number of test sample
- Group: 1=GDM; 0=Control group
- Variants and genotypes assignment
(1)rs1859489 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
(2)rs1965211 C>T: 1=CC genotype; 2=CT genotype;3=TT genotype
(3)rs208634 T>C: 1=TT genotype; 2=TC genotype;3=CC genotype
(4) rs2240794 C>T: 1=CC genotype; 2=CT genotype;3=TT genotype
(5)rs3189926 A>C: 1=AA genotype; 2=AC genotype;3=CC genotype
(6)rs3760675 T>C: 1=TT genotype; 2=TC genotype;3=CC genotype
(7) rs42318 C>T: 1=CC genotype; 2=CT genotype;3=TT genotype
(8)rs6570136 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
(9)rs7755323 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
(10)rs7814359 A>G: 1=AA genotype; 2=AG genotype;3=GG genotype
(11)rs899972 G>T: 1=GG genotype; 2=GT genotype;3=TT genotype
(12)rs1965211 Dominant model(CT/TT vs. CC): 1=CCgenotype; 4=CT/TT genotypes
(13)rs3760675 Dominant model(TC/CC vs.TT): 1=TT genotype; 4=TC/CC genotypes
(14)rs7814359 Dominant model(AG/GG vs.AA): 1=AA genotype; 4=AG/GG genotypes
(15)rs1965211 Recessive model(TT vs. CC/CT): 3=TT genotype; 5=CC/CT genotypes
(16)rs3760675 Recessive model(CC vs. TT/TC): 3=CC genotype; 5=TT/TC genotypes
(17)rs7814359 Recessive model(GG vs. AA/AG): 3=GG genotype; 5=AA/AG genotypes
- Variables for stratification analysis
(1) SBP_M (Mean SBP:110.08 mmHg,1=”≤110.08”；2= “＞110.08” );
(2)DBP_M (Mean DBP:69.53 mmHg,1=”≤69.53”；2= “＞69.53” );
(3)FPG_M (Mean FPG:4.79 mmol/L,1=”≤4.79”；2= “＞4.79” );
(4)1hPG_M (Mean OGTT 1h:8.26 mmol/L,1=”≤8.26”；2= “＞8.26”);
(5)2hPG_M (Mean OGTT 2h:7.11 mmol/L,1=”≤7.11”；2= “＞7.11” );
(6)HbA1c_M (Mean HbA1c(%):5.20 mmol/L,1=”≤5.20”；2= “＞5.20” );
(7) TG_M (Mean TG:2.54 mmol/L,1=”≤2.54”；2= “＞2.54”);
- Abbreviations：
(1) GDM: gestational diabetes mellitus;
(2) FPG(mmol/L): fasting plasma glucose;
(3) 1hPG(mmol/L): oral glucose tolerance test 1h plasma glucose
(4) 2hPG(mmol/L): oral glucose tolerance test 2h plasma glucose
(5) HbA1c(%): glycated hemoglobin
(6) SBP(mmHg): Systolic blood pressure;
(7) DBP(mmHg): Diastolic blood pressure;
(8) TG(mmol/L): triglyceride;
(9) TC(mmol/L): total cholesterol;
(10) HDL-c(mmol/L): high-density lipoprotein cholesterol;
(11) LDL-c(mmol/L): low-density lipoprotein cholesterol.
- NA: missing value
Supplementary material for “Genetic Susceptibility, Mendelian randomization and Nomogram Model Construction of Gestational Diabetes Mellitus”
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Supplemental Table 1. The primers sequence of functional variants using for PCR
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Supplemental Table 2. Demographic and clinical characteristics in cases and controls(mean±sd)
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Supplemental Table 3. Stratification analysis for associations of positive SNPs and GDM risk
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Supplemental Table 4. Association analysis of functional SNPs with GDM risk
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Supplemental Table 5. FPRP analysis for the significant association of rs1965211, rs3760675, rs7814359 and GDM risk
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Abbreviation:
(1)PCR: Polymerase Chain Reaction;
(2)GDM: Gestational Diabetes Mellitus;
(3)SNPs: Single nucleotide polymorphisms;
(4)FPRP: False-positive reporting probability.