Dataset DOI: 10.5061/dryad.stqjq2ck3

Description of the data and file structure

Horses (n = 22) were randomly assigned to receive CIBAS (2 mg/kg bupivacaine, 0.02 mg/kg epinephrine and 0.0002 mg/kg dexmedetomidine), or an equivalent volume of saline (control). Recovery quality was assessed by blinded anesthesia personnel using a semi-quantitative rubric used to score all anesthetic recoveries at our hospital. Pain scores for the first 24 hours postoperatively were assigned by blinded observers trained to use previously validated composite visceral and facial pain scales. A Chi square test for trend was used to compare recovery scores between groups and an unpaired t-test was used to compare the area under the curve (AUC_0-24h) for composite pain scores between groups.

Medical records were reviewed and study variables were complied in an Excel spreadsheet.

Files and variables

File: CIBAS_Data_set_for_EVJ.xlsx

Description: Excel spreadsheet with data for all horses enrolled in the study

Variables

• . = a period was used to identify cells where a datapoint was missing. This identifier was used throughout the data sheet and is different than NA which was used when a category did not apply to a specific horse.
• NA = "not applicable," used any time there was a column with a category that did not apply to a specific horse. Different from a "." which was used to denote a missing data point. Some examples in this data set include: 1) if a horse did not require rescue analgesia then that horse would have NA in the category "time rescue analgesia given;" or for the column "reason for rescue analgesia," if the horse did not require rescue analgesia then NA would be placed in that column for that horse.
• Treatment Group: Categorical to denote which of the 2 groups a horse was assigned to
  • CIBAS: caudal intercostal block for abdominal surgery (treatment group)
  • Saline: 0.9 % saline (control group)
• Breed: Categorical; breed of horse provided by owner, “QH/Paint” denotes Quarter Horse or Paint breed horses; TB denotes Thoroughbred breed horses; mixed breed means horses where the mother and father were of different breeds, Mini means American Miniature Horse, WB means Warmblood, TWH means Tennessee Walking Horse
• MRN: Categorical; horse identification number assigned by medical records system to anonymize names of study participants
• Randomization #: Continuous variable; number assigned to each horse denoting their treatment group (CIBAS or Saline), using a random number generator
• Age (years): Continuous variable; age of the horse provided by owner in years
• Sex: Categorical variable; biological sex as reported by owner
  • 1 = Mare (biologically female), 2 = Gelding (castrated biologic male), 3 = Stallion (biologically male)
• Admission date: Continuous variable; date horse was admitted to the hospital given as MM/DD/YYYY
• Anesthetist: Categorical variable; last initial of person administering anesthesia
• Surgeon/HO: Categorical variable; last initial of the person performing the surgery / last initial of person assisting with surgery
• Time between treatment and incision (minutes): Continuous variable; the number of minutes between when the treatment was performed (CIBAS or Saline) and when the first incision of surgery was performed, measured in minutes
• Person performing block: Categorical variable identifying the role of the person who performed the treatment (CIBAS or Saline)
  • HO = House Officer, a veterinarian in an advanced training program
  • Clinician = The senior veterinarian assigned to the horse
• Surgery date; Continuous variable indicating the date a horse underwent surgery, recorded as MM/DD/YYYY
• Diagnosis: Categorical variable indicating the abnormality found during surgery for each horse
• Strangulation or obstruction: Categorical variable indicating whether each diagnosis obstructed forward motion of ingesta (obstruction), or if the blood supply to a segment of bowel was compromised (strangulation)
• R&A (Y/N): Categorical variable indicating whether or not a segment of bowel was removed
  • R = resection, the act of cutting out a piece of bowel
  • A = anastamosis, the act of sewing the cut edges of bowel to each other
  • Y = yes
  • N = no
• Induction protocol: Categorical variable listing what drugs were used to induce general anesthesia in a horse
  • Ket = ketamine
  • Midaz = midazolam
  • Prop = propofol
  • GG = guaifenesin
• Inhalant type: Categorical variable indicating which type of inhalant anesthetic was used to maintain anesthesia in each horse
  • Sevo = sevoflurane
  • Iso = isoflurane
• Intraoperative constant rate infusions: Categorical variable denoting what medications were given at a constant rate during the period the horse was in surgery
  • Dexmed = dexmedetomidine
  • Lido = lidocaine
• Recovery method: categorical variable indicating what support horses had while they recovered from anesthesia
• Head/tail = a rope was used on the head and on the tail to assist the horse into a standing period during recovery from anesthesia
• Hand = the horse was recovered with a person in the stall guiding the horse. No head or tail ropes were used
• Pressors: Categorical variable; indicates what drugs were used to maintain a normal blood pressure
  • Dobut = dobutamine
  • NE = norepinephrine
• Volume expanders: Categorical variable indicating which (if any) product was used to increase blood volume during surgery
  • No = no volume expander was used
  • Hypertonic = hypertonic saline was used as the volume expander
• Albuterol (yes/no): Categorical variable indicating whether a horse received albuterol or not
• Recovery sedation: Categorical variable indicating what sedatives a horse received during their recovery from anesthesia
  • Xyl = xylazine
  • Dexmed = dexmedetomidine
  • Ket = ketamine
  • Ace = acepromazine
  • No = no sedatives given in recovery
• Reversal agents: categorical variable indicating what reversal drugs a horse received in recovery
  • Atipam = atipamezole
  • Flumaz = flumazenil
  • No = no reversal agents given
• Plasma given: categorical variable indicating whether or not a horse received plasma during surgery or recovery from anesthesia
  • Yes = horse received plasma
  • No = horse did not receive plasma
• Surgery duration (minutes): Continuous variable indicating the number of minutes each surgery took to perform
• Recovery duration (minutes): Continuous variable indicating the number of minutes it took each horse to stand after surgery
• Recovery score: Categorical variable indicating the semi-quantitative score each horse received. Indicates the quality of the recovery
  • 5 = ideal recovery
  • 4 = 2 to 3 attempts to stand
  • 3 = multiple attempts to stand with chance of injury; staggering
  • 2 = rough with thrashing, moderate injuries
  • 1 = recovery with major injury or unable to stand
• BW (kg): Continuous variable; body weight of the horse in kilograms, as determined by a scale
  • BW = body weight
  • kg = kilograms
• 1st manure (hours after returning to stall): Continuous variable indicating how many hours before the first pile of manure was produced
• Colon dumped (Y/N): categorical variable indicating whether or not the contents of the colon were evacuated during surgery
  • Y = yes
  • N = no
• PS V: Continuous variable: visceral pain score
• PS F: Continuous variable: facial pain score
• PS V + F: Continuous variable: visceral pain score
• Stall PS: Pain score when horse returns to the stall after surgery
• 2h PS: pain score 2 hours after horse returns to stall
• 4h PS: pain score 4 hours after horse returns to stall
• 6h PS: pain score 6 hours after horse returns to stall
• 8h PS: pain score 8 hours after horse returns to stall
• 12h PS: pain score 12 hours after horse returns to stall
• 16h PS: pain score 16 hours after horse returns to stall
• 20h PS: pain score 20 hours after horse returns to stall
• 24h PS: pain score 24 hours after horse returns to stall
• 36h PS: pain score 36 hours after horse returns to stall
• 48h PS: pain score 48 hours after horse returns to stall
• 72h PS: pain score 72 hours after horse returns to stall
• Re-explore (Y/N): Categorical variable; identifies whether or not a horse had a 2nd colic surgery during the same hospitalization
  • Y = yes
  • N = no
• Rescue analgesia needed: categorical variable recording whether or not a horse required pain medication after surgery beyond the standard protocol used in our hospital
  • n = No
  • y = yes
• Time rescue analgesia given (hours postoperative): continuous variable. Records how many hours after surgery horses received rescue analgesia. If the horse did not require rescue analgesia NA (not applicable, defined above) was recorded.
• Reason for rescue analgesia: categorical variable recording what clinical abnormality prompted clinicians to want to increase pain management.
• Survival to discharge (Y/N): categorical variable indicating whether a horse survived to hospital discharge, or died during hospitalization
  • Y = yes
  • N = n

Code/software

Microsoft Excel