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Data from: Spatial biases in visual feature representation of mouse dorsal lateral geniculate nucleus boutons

Krishnaswamy, Arjun1; Cha, Kuwook1

Published Jul 13, 2026 on Dryad. https://doi.org/10.5061/dryad.tmpg4f5f9

Data files

Jul 13, 2026 version files 3.12 GB

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Abstract

Humans and other mammals show spatial biases in their perception of visual features, with the primary visual cortex (V1) considered a key source. However, earlier structures may also contribute. Recent work shows feature biases in the retina, but little is known about how they evolve as signals flow through the dorsal lateral geniculate nucleus of the thalamus (dLGN). Using in vivo calcium imaging, we investigated spatial frequency, orientation, direction, and temporal frequency representations in both the retina and in dLGN boutons. We found modest location-dependent biases in the average representation of each feature across visual space for boutons, while such biases were weaker in the retina. dLGN representations emerged from functionally and anatomically defined bouton subsets. Selective ablation of cortical feedback to dLGN modulated feature biases but did not eliminate them. Together, these results suggest that dLGN integrates retinal and cortical inputs to create spatially biased feature maps for V1.