TORIE-DTI: Transient white matter changes under sevoflurane anesthesia
Data files
Mar 08, 2021 version files 6.05 GB
-
all_AD_A1.zip
310.34 MB
-
all_AD_A2.zip
309.40 MB
-
all_AD_D2.zip
302.25 MB
-
all_AD_D7.zip
286.18 MB
-
all_AD_Pr.zip
292.04 MB
-
all_FA_A1.zip
319.26 MB
-
all_FA_A2.zip
318.41 MB
-
all_FA_D2.zip
310.68 MB
-
all_FA_D7.zip
294.19 MB
-
all_FA_Pr.zip
300.20 MB
-
all_MD_A1.zip
308.34 MB
-
all_MD_A2.zip
307.45 MB
-
all_MD_D2.zip
300.25 MB
-
all_MD_D7.zip
284.24 MB
-
all_MD_Pr.zip
290.03 MB
-
all_RD_A1.zip
312.99 MB
-
all_RD_A2.zip
311.94 MB
-
all_RD_D2.zip
305.19 MB
-
all_RD_D7.zip
289.03 MB
-
all_RD_Pr.zip
294.94 MB
-
subj_demo.xlsx
11.37 KB
Abstract
Cognitive dysfunction after surgery under general anesthesia is a well-recognized clinical phenomenon in the elderly. Physiological effects of various anesthetic agents have been studied at length. Very little is known about potential effects of anesthesia on brain structure. In this study we used Diffusion Tensor Imaging to compare the white matter microstructure of healthy control subjects under sevoflurane anesthesia with their awake state. Fractional Anisotropy, a white mater integrity index, transiently decreases throughout the brain during sevoflurane anesthesia and then returns back to baseline. Other DTI metrics such as mean diffusivity, axial diffusivity and radial diffusivity were increased under sevoflurane anesthesia. Although DTI metrics are age dependent, the transient changes due to sevoflurane were independent of age and sex. Volumetric analysis shows various white matter volumes decreased whereas some gray matter volumes increased during sevoflurane anesthesia. These results suggest that sevoflurane anesthesia has a significant, but transient, effect on white matter microstructure. The role of white matter in the loss of consciousness under anesthesia will need to be studied and MRI studies with subjects under anesthesia will need to take these results into account.
MRI data obtained on Skyra 3T scanner. These are all the DTI metrics FA, MD, AD & RD nifti files for the 5 different time points. See paper for more detailed descriptions.
Standard tools such as FSL can be used to process the data. Subjects ID and codings are included. No missing values.