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Data from: Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

Cordeiro, Soenke1; Patejdl, Robert2; Baukrowitz, Thomas1; Musinszki, Marianne1

Research facility: Christian-Albrechts-Universität zu Kiel
Published May 04, 2026 on Dryad. https://doi.org/10.5061/dryad.x69p8d00j

Data files

May 04, 2026 version files 88.24 MB

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Abstract

The xanthone Mangostin from Garcinia mangostana was described as a potent modulator of several potassium channels, with large-conductance K+ (BK) channels as its primary target for vasorelaxation. The dataset compiles electrophysiological source data for the potassium channel screen, the characterization of Mangostin activation in BK channels, as well as the vascular BK/β1 subunit complex and reconstituted BK-Cav nanodiomains in whole-cell recordings. It further contains results of single-channel recordings, the files generated in molecular docking, and the force measurement data in native aortic tissue. These findings establish BK channel activation as the core molecular mechanism driving Mangostin’s vascular effects and define its structural mode of action, informing nutraceutical safety assessment and BK-targeted drug design.