Transcriptome dataset for: The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
Data files
Jul 07, 2025 version files 81.91 GB
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CO1_5m_C13_LIB_1.fq.gz
5.21 GB
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CO1_5m_C13_LIB_2.fq.gz
7.62 GB
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CO2_5m_C13_LIB_1.fq.gz
5.65 GB
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CO2_5m_C13_LIB_2.fq.gz
6.59 GB
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CO3_5m_C13_LIB_1.fq.gz
5.63 GB
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CO3_5m_C13_LIB_2.fq.gz
6.55 GB
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KO1_5m_C13_LIB_1.fq.gz
7.48 GB
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KO1_5m_C13_LIB_2.fq.gz
8.71 GB
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KO2_5m_C13_LIB_1.fq.gz
5.80 GB
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KO2_5m_C13_LIB_2.fq.gz
6.65 GB
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KO3_5m_C13_LIB_1.fq.gz
7.36 GB
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KO3_5m_C13_LIB_2.fq.gz
8.65 GB
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README.md
2.07 KB
Abstract
This original dataset was generated from transcriptome analysis of Chmp5-deficient versus control skeletal progenitor cells in the paper. The purpose of the experiment was to identify differentially expressed genes in Chmp5-deficient versus control periskeletal progenitor cells, which were obtained from Chmp5Ctsk and Chmp5Ctsk/+ mice, respectively. It includes data for 3 replicates (cells from 3 different animals) in each group.
Dataset DOI: 10.5061/dryad.z8w9ghxrk
Description of the data and file structure
Transcriptome analysis of Chmp5-KO and Control periskeletal progenitor cells (mouse)
Files and variables
File: CO1_5m_C13_LIB_1.fq.gz
Description: Control periskeletal progenitor cells sample 1-1
File: CO1_5m_C13_LIB_2.fq.gz
Description: Control periskeletal progenitor cells sample 1-2
File: CO2_5m_C13_LIB_1.fq.gz
Description: Control periskeletal progenitor cells sample 2-1
File: CO2_5m_C13_LIB_2.fq.gz
Description: Control periskeletal progenitor cells sample 2-2
File: CO3_5m_C13_LIB_1.fq.gz
Description: Control periskeletal progenitor cells sample 3-1
File: CO3_5m_C13_LIB_2.fq.gz
Description: Control periskeletal progenitor cells sample 3-2
File: KO1_5m_C13_LIB_1.fq.gz
Description: Chmp5-KO periskeletal progenitor cells sample 1-1
File: KO1_5m_C13_LIB_2.fq.gz
Description: Chmp5-KO periskeletal progenitor cells sample 1-2
File: KO2_5m_C13_LIB_1.fq.gz
Description: Chmp5-KO periskeletal progenitor cells sample 2-1
File: KO2_5m_C13_LIB_2.fq.gz
Description: Chmp5-KO periskeletal progenitor cells sample 2-2
File: KO3_5m_C13_LIB_1.fq.gz
Description: Chmp5-KO periskeletal progenitor cells sample 3-1
File: KO3_5m_C13_LIB_2.fq.gz
Description: KChmp5-KO periskeletal progenitor cells sample 3-2
Code/software
The raw Illumina pair-end reads were first aligned with ribosomal RNA (GenBank ID BK000964.1) with Bowtie2 v2.2.6. Reads that failed to map to ribosomal RNA were aligned with the mouse reference genome mm10 with STAR v2.5.3 editor.
Files can be opened and viewed in a text editor.
Access information
Other publicly accessible locations of the data:
- N/A
Data was derived from the following sources:
- N/A