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dc.contributor.author Jin, Wei
dc.contributor.author Riley, Rebecca M.
dc.contributor.author Wolfinger, Russell D.
dc.contributor.author White, Kevin P.
dc.contributor.author Passador-Gurgel, Gisele
dc.contributor.author Gibson, Greg
dc.date.accessioned 2008-03-28T14:09:28Z
dc.date.available 2008-03-28T14:09:28Z
dc.date.issued 2001
dc.identifier doi:10.5061/dryad.120
dc.identifier.citation Jin W, Riley RM, Wolfinger RD, White KP, Passador-Gurgel G, Gibson G (2001) The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Nature Genetics 29(4): 389-395. en_US
dc.identifier.uri http://hdl.handle.net/10255/dryad.120
dc.description.abstract Here we present a statistically rigorous approach to quantifying microarray expression data that allows the relative effects of multiple classes of treatment to be compared and incorporates analytical methods that are common to quantitative genetics. From the magnitude of gene effects and contributions of variance components, we find that gene expression in adult flies is affected most strongly by sex, less so by genotype and only weakly by age (for 1- and 6-wk flies); in addition, sex x genotype interactions may be present for as much as 10% of the Drosophila transcriptome. This interpretation is compromised to some extent by statistical issues relating to power and experimental design. Nevertheless, we show that changes in expression as small as 1.2-fold can be highly significant. Genotypic contributions to transcriptional variance may be of a similar magnitude to those relating to some quantitative phenotypes and should be considered when assessing the significance of experimental treatments. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.ispartofseries Nature Genetics en_US
dc.relation.ispartofseries Vol. 29 Issue 4, pp. 389-395 en_US
dc.relation.haspart doi:10.5061/dryad.120/1
dc.relation.haspart doi:10.5061/dryad.120/2
dc.relation.haspart doi:10.5061/dryad.120/3
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dc.relation.haspart doi:10.5061/dryad.120/38
dc.relation.haspart doi:10.5061/dryad.120/39
dc.relation.isreferencedby doi:10.1038/ng766
dc.relation.isreferencedby PMID:11726925
dc.subject genetic transcription en_US
dc.title Data from: The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster en_US
dc.type Article en_US
dc.contributor.correspondingAuthor Gibson, Greg
prism.publicationName Nature Genetics
dryad.dansTransferDate 2017-08-29T11:56:54.551-0400
dryad.dansEditIRI https://act.easy.dans.knaw.nl/sword2/container/4c80ef93-5edb-4714-a86d-ee312a6714df

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Title MFCS15a2 Data Set
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Description Original ScanAlyze file
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Title RR Slide 11b_Cy3
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Title MFCS3b Data Set
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Title MFCS1a Data Set
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Description Original ScanAlyze file
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Title RR Slide 16b_Cy3
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Title READ ME for Aging
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Description Original ScanAlyze file
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Title MFCS6a Data Set
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Description Original ScanAlyze file
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Title MFCS5a Data Set
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Description Original ScanAlyze file
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Title MFCS9a Data Set
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Description Original ScanAlyze file
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Title MFCS7a Data Set
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Description Original ScanAlyze file
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Title MFCS4a Data Set
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Description Original ScanAlyze file
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Title MFCS11a Data Set
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Description Original ScanAlyze file
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Title MFCS4b Data Set
Downloaded 22 times
Description Original ScanAlyze files
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Title UMFOS data set
Description Gene Expression Profiling Results; this is an excel file with all of the extracted raw fluorescence intensities for Jin et al at the top, log2 at the bottom
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Title RR Slide 10b_Cy5
Downloaded 33 times
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Title SGA sig Data Set
Downloaded 69 times
Description Gene Expression Profiling Results
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Title MFCS10b Data Set
Downloaded 24 times
Description Original ScanAlyze file
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Title MFCS15b2 Data Set
Downloaded 29 times
Description Original ScanAlyze file
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Title RR Slide 2a Data Set
Downloaded 28 times
Description Original ScanAlyze file
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Title MFCS11b Data Set
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Description Original ScanAlyze file
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Title MFCS10a Data Set
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Description Original ScanAlyze file
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Title MFCS16a2 Data Set
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Description Original ScanAlyze file
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Title RR Slide 16b_Cy5
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Title MFCS9b Data Set
Downloaded 23 times
Description Original ScanAlyze file
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Title RR Slide 16a_Cy3
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Title MFCS5b Data Set
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Description Original ScanAlyze file
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Title RR Slide 10b_Cy3
Downloaded 30 times
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Title RR Slide 11b_Cy5
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Title MFCS12a2 Data Set
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Description Original ScanAlyze file
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Title MFCS3a Data Set
Downloaded 22 times
Description Original ScanAlyze file
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Title Template Data Set
Downloaded 58 times
Description This is a pdf showing the location of the 48 12x8 grids used to collect the data. Note that there are only 8 clones in the last grid of each sector [12, 24, 36, and 28]
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Title Sex Specific List Data Set
Downloaded 36 times
Description Gene Expression Profiling Results
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Title RR Slide 16a_Cy5
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Title RR Slide 2b Data Set
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Description Original ScanAlyze file
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Title MFCS7b Data Set
Downloaded 26 times
Description Original ScanAlyze file
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Title UMFOS text file
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Description Gene Expression Profiling Results; this file contains the normalized relative fluorescence intensities used in the gene-specific models.
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Title MFCS6b Data Set
Downloaded 25 times
Description Original ScanAlyze file
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Title MFCS1b Data Set
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Description Original ScanAlyze file
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Title Clone LUT Data Set
Downloaded 110 times
Description Gene Expression Profiling Results; an Excel file listing the clones, their identity, and whether the sequence was reconfirmed after arraying
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