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A distributed circuit for associating environmental context to motor choice in retrosplenial cortex

Citation

Franco, Luis; Goard, Michael (2021), A distributed circuit for associating environmental context to motor choice in retrosplenial cortex, Dryad, Dataset, https://doi.org/10.25349/D99W4T

Abstract

During navigation, animals often use recognition of familiar environmental contexts to guide motor action selection. The retrosplenial cortex (RSC) receives inputs from both visual cortex and subcortical regions required for spatial memory, and projects to motor planning regions. However, it is not known whether RSC is important for associating familiar environmental contexts with specific motor actions. Here, we test this possibility by developing a task in which trajectories are chosen based on the context. We find that mice exhibit differential pre-decision activity in RSC, and that optogenetic suppression of RSC activity impairs task performance. Individual RSC neurons encode a range of task variables, often multiplexed with distinct temporal profiles. However, the responses are spatiotemporally organized, with task variables represented along a posterior-to-anterior gradient along RSC during the behavioral performance, consistent with histological characterization. These results reveal an anatomically-organized retrosplenial cortical circuit for associating environmental contexts to appropriate motor outputs.

Methods

The methods for data collection and processing are described in the associated manuscript.

Usage Notes

The README.txt file describes variables, units of measurement, procedures, and relationships between files.

Funding

Harvey Karp Discovery Award

UC MEXUS-CONACYT 648 Postdoctoral Fellowship

National Institutes of Health, Award: R00MH104259

National Science Foundation, Award: 1707287

Hellman Fellows Fund

Larry L. Hillblom Foundation

Whitehall Foundation