A cost-effectiveness analysis of second-generation antihistamine 1 receptor blockers and Japanese kampo shoseiryuto for treatment of perennial allergic rhinitis in outpatient settings in Japan
Data files
Mar 20, 2023 version files 10.75 KB
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_Input_data_probabilistic_sensitivity_analysis.csv
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_Input_data.csv
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Direct_calculations_.csv
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Direct_medical_costs_community_pharmacy.csv
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Direct_medical_costs_physician.csv
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Parameters_for_sensitivity_analyses.csv
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Pharmaceutical_charge.csv
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README.md
May 02, 2024 version files 6.36 KB
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_Input_data.csv
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Parameters_for_sensitivity_analyses.csv
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README.md
Abstract
Objectives:
Perennial allergic rhinitis (PAR) is common in Japan. Second-generation antihistamines (SGAs) are commonly used for its treatment; however, it remains unclear which SGA is the most cost-effective. Additionally, the pharmacoeconomics of Japanese Kampo shoseiryuto (which was traditionally prescribed to treat PAR in Japan) remains poorly understood. In this study, we aimed to investigate the effectiveness of various SGAs and shoseiryuto for the treatment of PAR in Japanese outpatients, from the healthcare payer’s perspective.
Methods:
The most cost- and clinically effective SGAs were determined from a list of six SGAs (bepotastine, 10 mg; cetirizine, 10 mg; ebastine, 10 mg; epinastine, 20 mg; loratadine, 10 mg; and olopatadine, 5 mg) together with shoseiryuto, using the overall improvement rate through a model-based analysis. The time horizon was 28 days. Costs were determined based on the Medical Fee Index in 2020. Deterministic and probabilistic sensitivity analyses were conducted to address the uncertainty of the base-case results.
Results:
Overall, bepotastine (10 mg) and ebastine (10 mg) were cost-effective. Shoseiryuto was less cost-effective than ebastine (10 mg) (dominated). Ebastine (10 mg) was the most cost-effective option based on deterministic and probabilistic sensitivity analyses.
Conclusions:
Ebastine (10 mg) was the most cost-effective treatment strategy for PAR among the agents evaluated in this study. This insight could aid in establishing an appropriate formulary for treating PAR in hospitals and communities.
README: Title of Dataset: A Cost-Utility Analysis of Oral Triptans for Migraine in an Adult Outpatient Setting in Japan
Author(s)
Naoto Nakagawa, Phar.D., Ph.D.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: n-nakagawa@pha.ohu-u.ac.jp
Masami Kashiwabara, B.S., R. Ph,
Qol Holdings Co., Ltd.
Email: m-kashiwabara@qol-net.co.jp
Kei Egawa, B.S.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: 716008@ohu-u.jp
Ayaka Sasaki, B.S., R. Ph.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: 717045@ohu-u.jp
File list
_Input data
Parameters for sensitivity analyses
File descriptions
Details for:_Input data
The file is a table to analyze for input with TreeAge Pro. Updated information is that drug prices were changed with two times multipling because because relevant articles to which I reffered in my manuscript set 28 days for treatment trial.
Format(s): .csv
Dimensions: 28 rows x 5 columns
Variables:
*Name: c_XXX means cost variables (unit is 'yen'), p_XXX means probability variables, and u_XXX means utility variables (unit is 'QALY').
*Description: definition of each variable.
*Root Definition: individual variables for a base-case scenario.
*Low and High columns: the low and the high numbers for one-way sensitivity analysis.
Details for: Parameters for sensitivity analyses
Format(s): .csv
Dimensions:28 rows x 7 columns
Variables:
- Parameter: identified parameters for sensitivity analysis
- Base case value: individual variables for a base-case scenario.
- Lower Limits: the low numbers for one-way sensitivity analysis.
- Higher Limits: the high numbers for one-way sensitivity analysis.
- Distribution: a type of distribution for probabilistic sensitivity analysis
- Distribution parameters: individual variables for probabilistic sensitivity analysis, the symbol "-" means "Not applicable".
- Reference number: listed number derived from articles, "NA" means nothing to be refered to corresponding parameters.